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OTAR3088
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PMC10698968
Fig. 1Patient’s data and generation of MFS derived cell line.
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PMC11429241
The human ovarian cancer cell line SKOV3 was obtained from the American Type Culture Collection (ATCC).
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PMC11484188
Despite application of several new drugs, such as daratumumab, bortezomib/lenalidomide/dexamethasone, in combination with hematopoietic stem cell transplantation, overall prognosis remains poor and the pathological mechanism of MM is still unknown.
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PMC11680562
The therapeutic benefits of metal NPs are maintained, while toxicity and environmental impact are reduced using green synthesis methods .
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PMC9143157
Since solid tumors have innumerable subpopulations (mutant cells, gene polymorphisms) even within the same patient, the surviving resistant clones may start to grow immediately if they are not eradicated by the administered antitumor agent.
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PMC10999934
Furthermore, the DEGs were subjected to KEGG pathway analysis and GO analysis using the “Clusterprofiler” R package.
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PMC9429973
SARSCOV2-vaccination appear to decrease the risk of mortality and hospitalization.
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PMC11657744
Cells were cultured on sterile glass coverslips and fixed using either ice-cold methanol for 5 min at -20°C or 4% paraformaldehyde (PFA) for 15 minutes at room temperature.
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PMC9429973
MF has an indolent progression over several years through different stages.
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PMC11240571
In addition, exosomal PD-L1 has been found in various studies to promote immunosuppression and the growth of multiple tumors.
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PMC11429241
In the process of scaffold microfabrication, key design factors include the matrix architecture, pore size and shape, mechanical stability versus void volume, surface properties, and degradation rate .
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PMC11551844
On HeLa cells, JDE and JDH showed IC50 values of 2.41 ± 0.31 μg mL and 8.79 ± 3.84 μg mL, respectively, whereas the IC50 values of AuNPs-JDE and AuNPs-JDH were 1.08 ± 0.09 μg mL and 1.58 ± 0.11 μg mL. On HepG2 cells, the IC50 values of JDE and JDH were 0.96 ± 0.81 μg mL and 3.76 ± 0.86 μg mL, respectively whereas the IC50 values of AuNPs-JDE and AuNPs-JDH were 0.40 ± 0.17 μg mL and 1.88 ± 0.65 μg mL, respectively.
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PMC11519567
Data are mean±s.d.,
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PMC11361748
Cells with the highest TAR11 scores (cut-off set at either the 95th and 75th percentiles) also show the highest levels of reads for inflammatory, immune response, and stress response genes including the highest levels of KRT6A and KRT17 mRNAs (Fig 9B, 9C, 9E, and 9F).
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PMC11089031
C Receiver operating characteristic (ROC) curve of the overall survival of patients with high and low ZNF692 expression.
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PMC11634027
PCV loss was scored manually and categorized as follows: no phenotype, incomplete PCV loss, and complete PCV loss.
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PMC11357960
P< 0.001.
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PMC5963610
These results suggest that those tumor cells, which resist the combination treatment, were selected to survive in the absence of EGFR and uPAR/α5β1 mediated signals.
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PMC10565698
Therefore, we performed nucleoplasmic separation experiments using HCCLM3 and BEL-7404 cells and found that circUSP10 was mainly expressed in the cytoplasm (Fig. 4A).
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PMC9429973
Results: We showed that Vγ9Vδ2 T cells exert spontaneous cytotoxicity against hematological cell lines and primary ALL blasts with a heterogeneous susceptibility depending on the target.
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PMC9429973
48% of patients experienced ICANS after axi-cel infusion compared to 22% after tisa-cel infusion.
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PMC9429973
Aims: To provide an updated follow-up of the D-ALBA trial and to document the long-term management of previously enrolled patients.
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PMC11420784
Abbreviations: 3-MA, 3-methyladenine; BEC, bladder epithelial cells; CFU, colony-forming unit; HBSS, Hanks’ balanced salt solution; ns, not significant; UPEC, uropathogenic Escherichia coli; WT, wild type.
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PMC10940855
G, Average radiance of RPMI-8226 multiple myeloma cells at day 5 of coculture with BMECs following treatment with sh-EFNB2 or sh-Control.
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PMC11678368
The similar Δ values for the Pt(II) and Pd(II) complexes suggest that the metal center has a minor influence on the relative stability of the complexes.
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PMC11525028
However, systematic screening and validation of vital molecules involved in RNA modification have not been reported in osteosarcoma.
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PMC11594588
Disturbances in redox reactions in the platelet mitochondrial membrane lead to the direct oxidation of cellular macromolecules, including nucleic acids (DNA base oxidation), membrane lipids (lipid peroxidation process) and cellular proteins (formation of reducing groups in repair proteins and amino acid peroxides).
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PMC11708541
Positive outcomes were found for internal library compound in the initial in silico study.
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PMC11063646
In the current study, the viscosity of emulgels increased with the concentration of xanthan gum, and the optimized gel (ANG12) demonstrated a viscosity of 5258 ± 132 p. This optimized viscosity facilitated controlled drug release observed in ex-vivo studies, with maximum skin retention of 784.78 µg/cm.
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PMC10142392
The cylindrical micelles of PEG-PCL2 with DOX as a model drug have demonstrated superior performance in terms of drug-loading capacity compared to the spherical micelles of the linear diblock counterparts.
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PMC11698348
Further analyses are required to better understand the importance of Elf5, and its role based on the spatio-temporal expression/localisation (nuclear vs. cytoplasmic) in particular in skin and HFs.
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PMC11574271
Nevertheless, the altered cell morphologies were accompanied by increased expression of N-cadherin and Vimentin, the phenotypic marker of epithelial to mesenchymal transition (EMT) (Fig. 3I, J).
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PMC7039683
Figure 1—figure supplement 6.Summary for RNA-seq for krt4:GFP-positive and krt4:GFP-negative cells at 4-somite stage.(A) Volcano plot for genes expressed in GFP-positive (in green) and –negative (in red) cells. (
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PMC8068766
Oxidative stress results from the inability of the biological system to detoxify the reactive intermediates or to compensate the resulting damage that is formed as a result of systemic accumulation of reactive oxygen species (ROS).
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PMC11723947
While most studies document concomitant inhibition of T cell proliferation and effector functions by Treg, the uncoupling we observed in HP1α-deficient CD4 T cells is not unprecedented.
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PMC11001582
WT (n = 4 mice), (GR)400 (n = 5 mice), (PR)400 (n = 5 mice); one-way ANOVA, Bonferroni’s multiple comparison.
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PMC10329074
Data were expressed as the mean ± s.d.,
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PMC11476837
Given that NRF2 inhibitors can simultaneously increase intracellular ROS and block NRF2 transcriptional activity, our results indicate that targeting NRF2 via K67, RA, and ML-385 has the potential to increase doxorubicin-induced cytotoxicity.
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PMC10969097
The immunomodulatory properties of mushroom polysaccharides are primarily responsible for these effects.
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PMC11686380
Data were analyzed using GraphPad Prism 8 software (GraphPad Software Inc., La Jolla, CA) and expressed as means ± SD.
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PMC11155445
Third, thiazole derivatives (19a-b) of the acyl thiourea were synthesized by dropwise addition of dialkyl acetylenedicarboxylates to a stirred solution of acyl thiourea (15) in ethanol at room temperature.
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PMC11634794
The correlation between LAMP1 expression and different clinical indicators as well as the relationship with patient prognosis was analyzed.
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PMC11721064
Therefore, we favored P1 SKCs for subsequent transdifferentiation experiments due to their enhanced KPCs enrichment.
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PMC10565698
In vivo experiments in nude mice also demonstrated that circUSP10 promoted tumor growth.
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PMC11087301
Induction of EMT downregulates PUMA enhancing CTCs’ survival in the bloodstream .
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PMC9429973
Most common (≥ 10.0% of pts) Gr 3–4 AE were fatigue (13 [36.1%] pts), visual acuity reduced (6 [16.7%] pts), and rash (5 [13.9%] pts).
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PMC10582049
Selection and utilization of the correct treatment strategy requires novel methods for the prediction of LUAD behavior and prognosis.
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PMC10788478
The surgical specimens were promptly frozen after sampling and stored at −80°C until genomic DNA extraction.
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PMC8873393
E Enlarged view of the genes with 1–5 introns shown in Fig. 4D.
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PMC9429973
Management of patients with aggressive lymphoma and cirrhosis is challenging and requires a multidisciplinary approach.
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PMC11139449
The CASP8AP2 gene knockout (CHO-KO) cells exhibited a higher IC50 compared to the CHO-K1 control group for 48 and 72 hours.
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PMC11543935
When using EP as an irreversible ablation technique for tumor cells, the aim is the disruption of the cell membrane integrity leading to apoptosis, rather than necrosis.
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PMC10538569
RLU in mock-, GPI-scFv X5 or AB65-transduced TZM.bl cells with or without trans-infection of iDC-captured HIV-1 Bru-3. ***
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PMC10976516
vvDD infection synergized with blockade of both PD-1 and TIM-3 through the efficient direct killing of lung cancer tumor cells and recruiting and activating T cells for indirect tumor killing, vvDD was shown to induce higher expression of both PD-1 and TIM-3 in refractory lung cancer.
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PMC9325715
Such nanoparticles are of high interest as they can be utilized as drug carriers.
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PMC9429973
Investment in patient information and patient-doctor relation is a key factor to motivate patients for trial participation.
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PMC11321678
Each column depicts a single cell from a specific subtype.
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PMC9429973
Throughout the first line treatment, 48% (46/96) patients were colonized by GNMRB, being the recovered microorganisms: Klebisella sp. 61% (28/46), Enterobacter sp: 17%, (8/46), Citrobacter sp: 11% (5/46), E. Coli: 9% (4/46), and Pseudomonas aeruginosa 2% (1/46).
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PMC6114978
Trichostatin-A (TSA) stimulated an increase in expression of MST2 in 8 of 12 sarcoma cell lines (67%).
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PMC10419319
These findings highlight the potential of isoalantolactone as a novel glycolysis inhibitor for treating cisplatin-resistant OC.
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PMC11297139
Scale bars: 5 μm.
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PMC9429973
Handling of D5PSS-4 subgroup requires further study in larger case series.
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PMC9429973
We further identified documented changes in clinical practice that occurred in direct response to CGP results.
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PMC11285179
Red blood cells were removed using a red blood cell lysis solution, followed by cell counting.
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PMC9599726
However, the protective effect on cell viability elicited by the iron chelator DFO was not complete, suggesting that, although ferroptosis largely contributes to VP-mediated cytotoxicity, other cell death mechanisms might also be involved.
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PMC11224020
Arrows highlight cell deformation events.
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PMC11545868
The binding of death ligands to receptors (e.g., Fas receptor, TNF receptor, and TRAIL receptor) results in receptor trimerization and recruitment of adaptor proteins such as the Fas-associated death domain (FADD).
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PMC11188874
E.G7-Ova or EL.4 cells were incubated with pharmacologics as indicated for 72 hours.
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PMC11098378
The final refined 2Fo-mDFc electron density map, contoured at the 1σ level, is shown superimposed on each residue, as well as a 180° rotation of this region.
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PMC11742231
Therefore, it concludes that using an adaptive fusion operation can effectively capture the complex relationships between drugs, proteins, and genes, and improve the accuracy and robustness of the model.
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PMC11200978
Protein analysis revealed that the increased cell death observed correlated with the upregulation of phosphorylated MLKL, a key mediator of necroptosis, and the downregulation of RIP3 kinase, an upstream regulator (Figure 5A–C).
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PMC8973085
Derivatives of thieno[2,3-b]pyridine-2,5-dicarboxamide 8a–8d can be obtained by the cyclization of compounds 7a–7d or directly from compounds 3a,b with 2-chloro-N-arylacetamide derivatives 6a,b, in sodium ethoxide solution (Scheme 3).
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PMC11119602
The HepG2 cell line used in our experiments was from the European Collection of Cell Cultures (ECCCs) and was cultured in RPMI 1640 culture medium (Invitrogen, Paisley, UK), fully supplemented with 10% (v/v) heat-inactivated foetal calf serum (FCS), 2 mM L-glutamine, 100 U/mL penicillin, and 100 µg/mL streptomycin.
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PMC9622879
Within the community, the total buying energy is equal to the total selling energy.
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PMC11568601
Human bone marrow mesenchymal stem cells (BMSCs) were acquired from Procell Life Science & Technology Co., Ltd. (Wuhan, China).
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PMC11352311
Among the proteins, GAPDH exhibited the lowest binding energy, with an affinity of −9.1 kcal/mol, suggesting that GAPDH may be the most central target of esculin in the treatment of RCC (Figure 2A) (Supplementary Table S3).
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PMC11055443
Recent studies support both the anti-microbial and the anti-inflammatory effects of MSCs making them a good candidate for the control of infectious and inflammatory diseases.
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PMC10938377
Nonetheless, we also observe gold adducts at H2B H46, and considering that the chromatin fiber in vivo would present a variety of nucleosomal structural contexts, alternative imidazole sites beyond H3 H113 (AU1/1′) may also be relevant given the cellular activities observed here.
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PMC9429973
All the patients were divided into two age-dependent groups according to the WHO classification: elderly (60-74 years old), n=67 (78.4%) and senile (75-90 years old), n=9 (21.6%).
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PMC9429973
With a median age of 35 yrs.,
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PMC8348645
While Vitis vinifera and W. somnifera show α-amylase inhibition, the IC50 value of C. sinensis was not calculated due to its lower % inhibition.
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PMC11519077
Besides, menstrual blood is a novel source of stem cells that can be readily obtained from female volunteers in a noninvasive manner without requiring ethical evaluation .
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PMC9596868
Quercetin acts as an anti-cancer chemo preventive and chemotherapeutic agent and its effects are reported for almost 20 different cancers using in vitro as well as in vivo assays (reviewed by Rauf et al) .
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PMC11711935
Photo‐damaged fibroblasts have melanin‐promoting functions and may take part in the pathogenesis of melasma.
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PMC11661040
After incubation for 48 h, the Transwell chamber was washed with PBS, fixed with 4% paraformaldehyde for 30 min, and stained with 0.1% crystal violet for 10 min.
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PMC11779993
Three to five bacterial colonies were inoculated into 5 mL TSB and incubated at 37°C for 4–6 h to reach the exponential growth phase.
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PMC9927933
For clonogenic survival assays, 500–1000 cells were seeded into 35-mm dishes in triplicate and grown for 14 days.
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PMC11754436
p<0.05, **p<0.01, ***p<0.001, the scale is 100 μm.
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PMC11661040
F-G) CCK8 assays demonstrated that the activation of Wnt pathways attenuated the inhibitory effect of CGREF1 on cell proliferation. (
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PMC10582049
In addition, the expression of these genes among other populations of cells and other CAF subpopulations was assessed.
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PMC11343332
represents statistical significance between control and drug treatment groups at the p<0.05 level.
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PMC11802929
For each 10x library, BAM alignment files from cellranger were filtered for reads from autosomes and sex chromosomes.
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PMC11747467
In contrast, TROP2 expression is higher in bladder cancer cells resistant to EV, which remain sensitive to SG (15).
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PMC11481779
In the case of the situation where the real distribution is equal to the generated one, we get FID equal to 0.0 - which is the highest possible FID score.
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PMC7823217
Moreover, 3D bioprinted tumor constructs can supplement animal xenograft models because they maintain cancer–stromal cell interactions.
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PMC11766332
Exclusion criteria were as follows: (1) pre-miRNAs, viral miRNAs, and non-miRNAs were not considered in the bioinformatic analysis, and (2) studies performed 15 or more years ago were not included.
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PMC11507371
Overall, the quantification revealed similar values in both cell lines.
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PMC11129910
Loss of RAB25 in breast cancer is not noted in CBioPortal data, but our previous studies indicate that it can occur with significant frequency in triple-negative breast cancers .
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PMC11794568
Two human cutaneous melanoma cell lines, including SK-MEL-2 and A375, were obtained from the Cell Bank of the Chinese Academy of Sciences (Shanghai).
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PMC11252553
mL for both Taurine and cysteine.
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