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PMC11621493
Primary keratinocytes were isolated from two-day-old WT (n = 5) and KO (n = 8) neonatal mice and cultured for four days under low CaCl2 concentrations (0.06 mM).
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PMC11792740
Additionally, using multiplex immunofluorescence, Tumeh et al. (2014) demonstrated the spatial relationship between exhausted T cells and PD-L1-expressing tumor cells in melanoma, providing insights into the TME that predict responsiveness to immunotherapy .
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PMC6487404
The present study aimed at exploring the potential of the P-glycoprotein (P-gp) transporters as a barrier to the repaglinide (REG) epithelial permeability.
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PMC11576293
To enhance the antiproliferative effect of 2-TPs by inhibiting tumor angiogenesis regulators, the 2-thiol moiety was changed with either small, (un)branched alkyl groups or bulky benzylic groups.
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PMC10887351
Through β3-ARs, which are expressed in the smooth muscle cells of the urinary bladder, the sympathetic system could mediate the detrusor muscle relaxation, improving the filling capacity of the bladder via cAMP signaling .
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PMC11755519
In the case of exosomes derived from malignant cells, the formation of a HUVEC monolayer was observed, followed by its disruption, demonstrated by a decrease in TEER measurements.
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PMC11021472
Cells were plated into 96 wells plates containing 100 µL of 1:8 normal medium:Methocult medium (Stemcell Technologies, Vancouver, Canada), aiming at 1 cell per well.
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PMC7452526
The anticancer effect of synthesized CN–Ag against Caco-2 has been tested.
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PMC11739504
NIH/3T3 cells were treated with serum starvation for 24 h and 500 nM of SAG for activation of Hh signaling. (
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PMC11705547
Type I IFN and ISGs enhance the anti-tumor innate and adaptive immune responses, the augment the effects of immunotherapy .
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PMC9429973
Therefore, there is a need for a relevant diagnostic tool, that will also allow sensitive disease monitoring and accurate assessment of treatment response.
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PMC11412752
After monoclonal cell formation, total DNA of the cells was isolated, and PCR reaction was performed with primers designed on the exon 6 of human STING (Table 3).
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PMC11756907
The appropriate dosage of GO-2-ME/rGO-2-ME, where GO/rGO is a carrier of 2-methoxyestradiol (2-ME), ensures efficient penetration of the active substance through biological membranes and controlled modification of cell signalling, ultimately leading to the selective elimination of cancer cells.
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PMC9429973
With a median follow up of 9.87 months (range 2.5-18), the median response duration is 6.3 months (range 1.6-14.3) with a median OS of 17.34 months (range 2.5 – 18).
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PMC11742231
Employing GNNs in this context offers significant benefits, as they can effectively integrate graph-based information into the model.
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PMC8009078
Virtual screening of phytochemicals through the pharmacoinformatics approach has become a vital tool in the drug discovery and development phase.
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PMC11438317
Once the TCR is engaged, most of these proteins organize into signaling complexes called microclusters, which are nucleated around several adaptor proteins .
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PMC11791478
The drug-to-antibody ratio for XB002 was calculated using peak areas obtained from reduced reverse-phase high-performance liquid chromatography (HPLC).
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PMC11711127
Additionally, a subset of naive T cells, such as those expressing high levels of CD5 or low levels of Ly6C, has been shown to retain higher self-reactivity in the periphery (2728).
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PMC11705901
Associations with complex traits and psychopathology have been established for several common polymorphisms of the OXTR gene .
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PMC9532503
Our results prove that osmolality is inversely proportional to afucosylation.
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PMC11453018
Data were normalized to B2M and are presented as fold change compared to the control group.
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PMC9693627
This fact allows suggesting that PTCD2 is associated with mitochondrial translation apparatus.
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PMC10547921
IR700 is a small, photoactivated molecule that can be excited by near-infrared light and has no phototoxicity or biotoxicity.
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PMC11770199
We also evaluated the intratumoral infiltration of macrophages and found that there was no significant change among 3 treatments, whereas the activation marker of MHC-II (major histocompatibility complex II) in macrophages was significantly increased after mMSCs-p14 treatment (Fig. 5C and D).
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PMC10142392
As a result of the flexibility of these combined techniques, a diverse array of architectures can be obtained.
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PMC11656657
T-test and Two-way ANOVA was applied for the analysis. *
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PMC11774747
Among the reported cases of GvHD, it appears that most of them are reactivations (2/3).
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PMC11695546
Comparing between impact of crude coconut oil and after exposing to O3 on viability % of A431- cells at different concentrations of oils Determination of cytotoxic effect of different coconut oil and after exposing to O3 on A431 cells (Data are tabulated as means ± SD) (A) A regular monolayer A431 control cells; (B) A431 cells treated by various levels of crude coconut oil and (C) A431 cells subjected to different concentrations of ozonized coconut oil. (
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PMC11682525
Subsequently, both hypoxia-preconditioned cell types were exposed to varying concentrations of H2O2, ranging from 200 to 2000 micromolar, for a duration of 24 hours.
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PMC11711663
Our study differs from previous research by focusing on the susceptibility or risk associated with the biomarker, specifically the increased likelihood of progression within 2 years post-treatment.
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PMC9479186
C, D) Transwell assay of HCC cells transinfected with Lv-shNDUFC1 or Lv-shCtrl. **
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PMC10955424
Combination of 2HE2, an estradiol derivative devoted of estrogenic activity, was successful in restoring platinum sensitivity to OC (Fig. 5).
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PMC10218459
The isolated direct and indirect application of CPP has been investigated on osteosarcoma cells , but also on Ewing sarcoma and chondrosarcoma cells .
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PMC9429973
Methods: We included HL patients diagnosed at the University Hospital of Padova between 2004 and 2020.
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PMC11632064
Notably, the pro-inflammatory transcript CXCL8 was among the top differentially expressed transcripts in A-375 cells (Fig 3B).
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PMC6600592
Molecular docking results clearly revealed interactions between ligands and protein in the active site.
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PMC11699465
R1 and R2 are two independent Cut&Tag tests with different sequencing depth. (
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PMC11743316
In addition, mitochondria serve as the cellular factories that create reactive oxygen molecules, which will stimulate tumor malignancy through the reactive oxygen species (ROS) dysregulation pathway .
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PMC9786247
Secretion of pro-inflammatory cytokines stimulates the migration of somatic cells and neutrophils to the udders .
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PMC11753435
Two datasets were curated: (i) a “strict” peptide-protein dataset, which filters for strong interactions (cocrystals with a buried surface area ≥ 400 Å), with peptides of length ≤25 amino acids and target proteins of length ≥30 amino acids; (ii) a “noisy” dataset, which contains both strong interactions and filters the PDB-derived data for weaker interactions (cocrystal buried surface area ≥ 50 Å) as well as interactions between all proteins (<50 amino acids) paired with a larger protein (>50 amino acids).
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PMC10055960
This would allow for accurate selectivity studies against healthy non-tumorigenic cell lines.
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PMC10125312
This setting was selected after evaluating the effect different powers and time of irradiation had on cellular viability on 786-0 cells (Table S1).
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PMC11013014
Following general procedure, the crude residue was purified by silica gel column chromatography, using DCM/EtOAc, 4:1 (v/v) as eluent, to obtain the expected product 8 as a white solid with a yield of 40%.
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PMC9105697
The mean coverage of each tumor sample was 889 x (SD 357 x), and the mean on-target rate after double-capture was 86.5% (SD 6.2%) (Figure 1C).
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PMC11186948
Signal was detected at PerkinElmer Ensight™ plate reader.
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PMC11549062
The results revealed that the expressions of PTP1B and Rab5 were significantly elevated in vulnerable plaques compared to stable plaques (Figure 1A,B).
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PMC11486946
Thus, the increase in brightness could be used as a screening index to assess signal transduction.
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PMC10900886
The intracellular expression of capsid protein VP1 was detected at 6 and 24 hpi by flow cytometry as described below.
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PMC11604768
Having detected transcriptional changes mediated by exogenous, overexpressed GPCR agonism, we next asked whether the TRE-MPRA platform can detect transcriptional changes due to endogenous GPCR agonism, as well as changes resulting from receptor overexpression in the absence of an exogenous ligand.
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PMC11767582
Cytotoxic drugs work by interfering with the cell’s ability to divide and proliferate, ultimately leading to cell death .
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PMC9398137
Venetoclax (ABT-199), a small-molecule inhibitor of BCL2 protein, has shown clinical activity in some hematologic malignancies and is currently the only BH3 mimetic approved by regulatory authorities for the treatment of chronic lymphocytic leukemia and acute myeloid leukemia (5–7).
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PMC8097906
The dry extract powder was dissolved in EtOH to a stock solution of 100 mg/ml.
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PMC10237474
In addition, CHO cell lines are often not suitable for producing proteins with many glycosylation motifs for structural biology studies, as N-linked glycosylation of proteins poses challenges for structure determination by X-ray crystallography.
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PMC11442172
Recognition of the impact of cell culture medium composition on the transcriptomic, epigenetic and metabolic profiles of cells has grown considerably over the past years (13, 92, 93).
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PMC2777936
WNT5A was the most highly expressed Wnt ligand uncovered in basally growing NT2/D1 cells.
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PMC10914904
It has been reported that the overexpression of MVP plays a role in this process.
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PMC11564322
The c-SRC inhibitor I decreased the ELANE mRNA expression by 50.46%, compared to the control.
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PMC11317131
Media for HEK293, HEK293T, HeLa, K562, and U2OS cells was supplemented with 10% heat inactivated FBS (Neuromics), 1x Penicillin/Streptomycin (Gibco), and 0.75 μg/ml Amphotericin B (Gibco).
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PMC11657695
Statistical analyses were performed using GraphPad Prism Software.
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PMC9429973
Methods: This retrospective analysis was performed on a cohort of patients from the US-based Flatiron Health electronic health record-derived de-identified database, who had newly diagnosed AML and received induction therapy with VEN-AZA or IC between 21 Nov 2018 and 01 Jun 2021.
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PMC9429973
Patients were required to be continuously enrolled in their health plan one year pre- and post-initiation with VO or VR.
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PMC11767725
These lipid changes directly influence the metabolic activity of the microbiota.
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PMC11766174
To the contrary, staining of MOLT IIIB with anti-CA antibodies displayed the intracellular chromogenic signal for 99.9% of cells with positive nuclear staining, as expected (Figure 1B and Table 1).
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PMC6892818
By contrast, in normal proximal tubule cells cultured in vitro CD40 ligation induced both pro-inflammatory cytokine secretion and anti-inflammatory signals.
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PMC10729469
Sc8066, Santa Cruz Biotechnology, Dallas, TX).
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PMC6742971
Our results show that also in vivo, the anti-tumor effect of high avidity T cells is not hampered by the co-presence of T cells with lower avidity.
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PMC9646302
LAPTM5 plays a negative regulatory role in T and B cell activation and is widely involved in tumor growth.
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PMC11757131
Detection of lipid droplet synthesis using Oil Red O staining.
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PMC3734024
Membranes were blocked and incubated with polyclonal rabbit anti-FasL IgG (Millipore) or anti-β-Actin (Cell Signaling).
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PMC6450504
Briefly, ePC, Chol and PTX were solubilized in a chloroform/methanol mixture, and the organic solvents were removed to form the thin lipid film.
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PMC9429973
Fourteen and 8 patients received second and third-line therapy, respectively.
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PMC11772585
The relative protein level was calculated.
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PMC11222184
Numerous studies have indicated that HSP90 inhibitors reduce cell proliferation by causing apoptosis in cancer cells .
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PMC6600253
Each cell division leads to the loss of 50–200 bp of unreplicated DNA at the 3′ end of the telomere.
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PMC11803918
All animals received care, and experiments were conducted according to the protocol approved by the Committee on the Use of Live Animals in Teaching and Research (CULATR) Li Ka Shing Faculty of Medicine (CULATR No. 5715–21, CULATR No. 22–172).
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PMC9429973
Improvements in the symptom scales, including fatigue and dyspnea scales, were also observed in the PEG group at Week 26 as indicated by a reduction in the symptom score close to the general population norms (general population norm: fatigue: 24.1, dyspnea: 10.9).
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PMC3888431
Chinese hamster ovary (CHO) cell lines represent the most commonly used mammalian expression system for the production of therapeutic proteins.
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PMC10873328
To validate hub HRGs in hypoxia condition, the hypoxia-sensitive human ovarian cancer cell, SKOV3, was cultured under normoxia and consistent 1% O2 hypoxia condition for 24 h, respectively.
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PMC11701801
Mice in the drug treatment group were injected orally with either vehicle [PBS or 0.5 w/v% methyl cellulose 400 solution (FUJIFILM Wako, 133-17815)] or CP-C27 (30–50 mg/kg) once daily or twice daily for 14 to 28 days.
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PMC10335954
The primary antibodies, including anti-interleukin 6 (IL-6), anti-caspase-3, and anti-TRIP13, were purchased from Santa Cruz, USA.
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PMC11509278
These findings may provide valuable insights for the development of targeted therapies for the treatment of cutaneous squamous cell carcinoma.
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PMC10530622
A mice model of progressive oxalate nephropathy obtained from a high soluble oxalate diet (i.e., high in oxalate with an absence of dietary calcium) showed higher deposition of CaOx in kidney interstitium and infiltrates of mononuclear cells, particularly monocytes/macrophages, when compared to control mice (i.e., high-oxalate diet in the presence of dietary calcium) .
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PMC11281366
Figure 6A shows that the transfection of miRNA-26a mimics does not interfere with viral replication as virus production was comparable between miRNA-26a and control mimic-treated cells.
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PMC11087766
DAPI-stained foci indicative of phage genomes were measured at their widest point using the DeltaVision SoftWoRx 6.5.2 Image Analysis Program.
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PMC11747949
In the coculture, we noticed that increased VEGF secretion was more pronounced in hypoxia than in normoxia.
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PMC11774251
Tan-I ameliorated the psoriasis-like lesions, as evidenced by reduced superficial redness, scaling, and crust formation, compared to the vehicle group (Figure 1C).
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PMC11531744
As shown in Fig. 8C, si-GBP1P1 and red fluorescent protein were co-expressed on the carrier, and the transfection efficiency was directly visualized by fluorescence, indicating that siRNA had been transferred into the W038 cell.
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PMC11190538
Small letters differ significantly (p ≤ 0.05) in treatments.
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PMC11538390
Samples from the Estonian Biobank cohort were genotyped at the Core Genotyping Lab of the Institute of Genomics, University of Tartu, using Illumina Infinium Global Screening arrays v1.0, v2.0 and v2.0_EST.
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PMC11656657
GD2 surface expression was analyzed on fresh tumor biopsy samples and PBMC from sarcoma patients using a conjugated mouse anti-human GD2-BV421 monoclonal antibody (clone 14.G2a, BD Biosciences, USA).
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PMC11763533
Due to their intrinsic pH- sensitivity, in recent years we have demonstrated that firefly luciferases can also be harnessed as color- tuning sensors of intracellular pH. However, it is known that mammalian cells require temperatures higher than 36 °C, which red-shift the bioluminescence spectra of most firefly luciferases, decreasing their activities and the resolution of ratiometric pH analysis.
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PMC9429973
Treatment lasted until Week 26.
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PMC9429973
Search strings included the MeSH terms for three types of HM: CLL, MM, or NHL; types of HM that are more chronic than others.
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PMC11587606
The first part is RHBDF1-stimulated activation of PKCζ and importin β1-assisted translocation of activated PKCζ.
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PMC9822769
Furthermore, OCT1 and OCT2 are overexpressed in several colon cancer cells and appear to mediate selective cellular uptake and, hence, the cytotoxicity of oxaliplatin in colorectal carcinomas.
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PMC10728200
In addition, The fluorescence intensity of FerroOrange was increased in GIST-T1 and GIST-882 cells treated with IM compared with that in untreated cells, illustrating that IM promoted the accumulation of Fe in GIST (Fig. 1F).
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PMC9370419
Pegylated interferon can achieve HBsAg loss in a certain group of patients, but the treatment requires inconvenient subcutaneous injections and may lead to significant side effects in some patients ; therefore, new treatment strategies need to be explored.
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PMC11286266
Intriguingly, its ER-membrane counterpart, CNX, did not emerge in our screen, despite the inclusion of six sgRNA targeting CNX in the CRISPR library.
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PMC7081114
Green fluorescence was used to estimate the efficiency of transfection.
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