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OTAR3088
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PMC11720107
Our previous study linked the strong cytotoxic properties of the Morado cultivar to its suspected high polyphenol content.
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PMC11397654
The toxicity toward the healthy cells was lower for all derivatives, the IC50 being 4–18 times smaller than for malignant cells.
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PMC11585587
The molecular docking research was carried out using AutoDock 4.0 software.
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PMC10317042
P < 0.05; **, P < 0.01; ns, nonsignificant (Student t test).
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PMC11352746
Alternatively, more nuanced image analysis techniques have been outlined by Bellon et al., including advanced image analysis algorithms that allow for precise quantification of neurite length and morphology .
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PMC11703992
A The volcano plot presented the genetic effects of differentially expressed genes in CD4+ Memory T cells on GCA, from which 6 genes with significant effects were selected as significant exposures.
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PMC9119314
The crystal structure confirms 7, 9-diiodo-substitution of the indole ring; the protonation of nitrogen N (1) and the presence of a chloride anion indicate the hydrochloride salt; one molecule of water is associated with each molecule of 6.
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PMC11144382
BBX encodes a transcription factor that binds to DNA to promote cell cycle progression from the G1 to S phase.
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PMC11753435
After 24 hours, cells were cotransfected with 0.2 mg of the SS18-SSX1-mCherry plasmid and 0.2 mg of each uAb encoding construct plasmid DNA in triplicates using Lipofectamine 2000 (Thermo Fisher Scientific, 11668019) as per the manufacturer’s directions.
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PMC9429973
Unfortunately, a substantial population of patients undergo relapse, resulting in poor clinical ramifications.
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PMC10094712
Protein binding to nickel agarose was carried out at 4 °C for 3 h, after which it was thoroughly washed with a buffer (50 mM NaH2PO4, 300 mM NaCl, 20 mM imidazole, pH 8.0); then the protein was eluted from the column by incubation with the same buffer, but the content of imidazole in it was 150–250 mM. The recombinant proteins were analyzed by PAGE electrophoresis using 10 or 12% polyacrylamide resolving gels.
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PMC8143558
The antiviral activity was noted by monitoring changes in the diarrheal symptoms that were induced by the rotavirus.
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PMC11640247
Notably, the variant induces these phenotypes through specific molecular mechanisms distinct from other RAC3 pathogenic variants, emphasizing the complexity and diversity of RAC3-mediated signaling pathways.
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PMC11621565
Statistical analyses used fold-change calculation as fold increase to control followed by statistical significance testing (One-Way ANOVA followed by Dunnett’s Test), *p < 0.05, **p < 0.01, ***p < 0.001.
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PMC7612475
To examine the impact of SF3B1 mutation on HR further, we assessed sister chromatid exchanges (SCE), an end product of a proportion of HR-mediated repair events.
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PMC9164404
B Subsequently, Abplatin was intraveneously (i.v.)
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PMC10965680
Together with those of the Xiangdong black goat, the genomic data of the other 6 goat populations of 19,133,125 biallelic SNPs were screened largely in intergenic and intron regions (58.12% and 37.97%, respectively).
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PMC10470467
As we know, chemotherapy is the most conventional treatment for ES.
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PMC9878278
We further confirmed that the downstream IFN signaling in SC is comparable to other cell types.
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PMC7642379
Due to the observed pattern of common genomic changes to progeny cell lines compared to the parental HEK293, an evaluation of common SNPs amongst all progeny cell lines but not HEK293 was performed.
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PMC9635307
However, such increase of Ca concentration was suppressed in A20/2L (Fig. 3b).
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PMC3274243
For this reason, the observations from parallel chamber slide cultures provide important information, not least an assessment of cell confluence and, if necessary, the fixation and staining of specific processes/proteins/morphology.
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PMC11371747
In this cell line inhibition of intracellular TS could be enhanced moderately by l-LV and dl-LV but not by d-LV.
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PMC11765988
Inflammatory cytokines (e.g., tumor necrosis factor-α, interleukin-6, and transforming growth factor-β, nitric oxide, and vascular endothelial growth factor) can increase the risk of malignancy when produced excessively, as they may promote angiogenesis, cellular proliferation, stromal growth, and tissue remodeling.
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PMC7305184
Increased cell membrane permeability is also being exploited in electrochemotherapy (ECT).
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PMC10329237
Cells were exposed to BLM (0.1 μg/ml) and co-treated with LOS (0.2–0.5 mM) and PFD (0.2 mM), either alone or in combination. (
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PMC9429973
Patients included in the PROMs program reported fewer general (64.5% vs. 84.8%; p<0.05) and infectious (30.3% vs. 59.1%; p<0.05) AEs than those in the control arm.
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PMC11720808
Ki67 and p-p65 immunohistochemical staining of representative tumors in each group.
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PMC10758402
This results in enhanced viral output, as well as significantly enhanced oncolytic effects within multiple human and murine cancer cell lines ( Figures 1B, C, G ).
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PMC10919056
LASSO regression model of OR-GJPs: (A) Coefficient distribution diagram. (
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PMC9429973
In parallel, CNS status was concluded according to morphological criteria, being classified as CNS1 (no blasts), CNS2a/b (≤5 WBC/μL with blasts), CNS2c/CNS3 (≥5 WBC/μL with blasts) according to treatment protocol guidelines.
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PMC11754784
Additionally, the involvement of other ligands apart from aptamers, for example, nanobodies (Nbs), into molecular computation will greatly expand the cellular recognition toolbox and promote the performance in sensing, manipulating, and responding to intricate cellular milieus.
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PMC11731614
N = 7 across biological replicates from both male and female mice.
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PMC11095939
Thus, enhanced reduction of Mecp2 stimulates exit from quiescence. (
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PMC9621239
WT, wild type.
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PMC9429973
As shown in the Figure, for those who received subsequent therapy (n=116), the median duration of the immediate post-cBTKi/BCL2i therapy was 4.8 months (95% CI: 3.0-7.3).
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PMC11767725
Advances in metabolomics and microbiome sequencing have unveiled critical biomarkers, such as short-chain fatty acids and microbial signatures, predictive of therapeutic outcomes.
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PMC11470999
Penfluridol (PF) inhibits melanoma cell proliferation in vitro and tumor growth in vivo. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Penfluridol", "(", "PF", ")", "inhibits", "melanoma", "cell", "proliferation", "in", "vitro", "and", "tumor", "growth", "in", "vivo", ".", "(" ] } ]
PMC11190238
These EMT TFs themselves are often epigenetically regulated thus forming a reciprocal feedback control.
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PMC11470381
A polarity index greater than 1 signifies skewed frontal polarization and distribution of the fluorescent signals (Figure 5A).
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PMC11634794
A nomogram predicting 1 -, 3 -, and 5-year survival in ccRCC patients.
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PMC11742670
The proposed architecture serves the paramount objective of predicting IC50 values, facilitating the evaluation of new drugs, and the identification of potentially potent candidates for further exploration.
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PMC9429973
Results: LILRA4 transcripts showed a bimodal expression pattern for MCL PB and BM samples with high expression in half of the cases.
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PMC9429973
Modified 3 + 3 and accelerated titration design was utilized.
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PMC5941560
MSigDB data sets were downloaded from the Broad Institute website (http://software.broadinstitute.org/gsea/downloads.jsp).
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PMC11306019
They offer various health benefits, including anticancer properties, making polyphenol-rich foods and supplements beneficial for health and disease prevention.
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PMC9503685
The presence of intracellular bacteria may cause recurrent infections and makes the treatment of infections, such as those associated with CF, difficult to treat.
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PMC11698348
Furthermore, using RT-qPCR, we validated Elf5 expression in these SC colonies after lentiviral treatments (S2c and S2d Fig).
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PMC11707832
Consequently, there is a pressing need for a concerted effort to enhance the basic and clinical knowledge of MN2B1 for the treatment of these diseases.
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PMC8389560
All values are given as mean ± standard error (SEM) or typical Ca+ signals.
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PMC11622247
Harsher microporation would result in more efficient delivery.
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PMC11367146
Red indicates highly expressive genes, whereas blue indicates less expressive genes of OA. (
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PMC11802855
A p-value less than 0.05 was considered statistically significant unless otherwise specified.
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PMC11747467
Subsequently, a GISTIC score (G-score) for individual genes with gain or loss was generated separately in MIBC.
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PMC11401358
OH was generated using the Fenton reaction between Fe and H2O2, which can react with 3,3′,5,5′-tetramethylbenzidine (TMB) to form a soluble blue compound with a characteristic absorption at 652 nm.
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PMC11779605
This panel consists of 770 genes involved in tumorigenesis, metastasis, and inflammation.
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PMC9847912
GSK254 is being further evaluated in two phase IIb studies (clinicaltrials.gov NCT04493216 and NCT04900038).
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PMC11705547
Following nuclear translocation, cisplatin creates intra- and interstrand crosslinks in the DNA molecules.
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PMC11697703
Scrambled control miRNA oligonucleotides did not repress the MapK8 luciferase reporter gene.
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PMC11761919
The density of bacterial cells plus PINs was the highest after culture for 15 h. (C) Effects of PINs and inulin on expression level of Fiber2 protein delivered by E. faecalis.
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PMC9784246
Ursolic acid, obtained from the leaves of the B. uncinella plant, has also demonstrated potent effects against experimental visceral leishmaniasis brought on by L. infantum, and it has been found to reduce the parasite load in the spleen and liver .
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PMC9429973
The responses in SF wt patients included one mCR (5% to 1% marrow blasts in a patient with DNMT3A and ETV6 mut and del(chr7)), and one HI-P (82 BL to 234 max in a patient with DNMT3A, IDH2, ETV6 mut and del(chr7)).
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PMC11753949
A subset of these synaptopodin- and actin-positive elements had the appearance of stress fibers.
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PMC9895440
Handling of potentially hazardous materials was conducted according to local safety standards and approved by the federal authorities (BAFU CH, approval number A172087).
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PMC8193046
The clear limit of C@PA was the prediction of ABCC1 inhibitors, as the discovered multitarget ABCB1, ABCC1, and ABCG2 inhibitors 7–11 were the only present ABCC1 inhibitors in the biologically evaluated set of 23 compounds .
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PMC10291556
Relative fluorescence intensity was calculated as the median fluorescence of the population of treated cells/median fluorescence of untreated control cells.
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PMC10747160
Samples were then diluted in Standard/Sample Diluent (R1) (ABclonal Cat # RM00023, Woburn, MA, USA).
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PMC11770130
Index of the reference genome was built using Hisat2 and paired-end clean reads were aligned to the reference genome using Hisat2.
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PMC11476837
The intensity of fluorescence was measured with λex = 495 nm and λem = 530 nm using a microplate reader Synergy HT (BioTek Instruments, Winooski, VT, USA).
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PMC10048572
Genetic lesions found at disease onset often belong to a predominant tumor clone, and further observation makes it possible to assess the fate of this clone during therapy.
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PMC6450504
Results show that the size of bPEI-coated liposomes did not change significantly (Figure 1(b)).
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PMC11802929
Average values were calculated for all residues, including anchor and exposed residues.
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PMC11781181
However, whether ferroptosis occurs in SJS/TEN and whether it plays an important role in their pathogenesis remains unknown.
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PMC11320834
The incorporation of PARPi has transformed the treatment of patients with HGSC, EC, primary peritoneal, and fallopian tube cancers [16–18].
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PMC3164356
To resolve these gaps, we used the paired-end information to retrieve the read pairs that had one end mapped to the unique contig and the other located in the gap region and then performed a local assembly for these collected reads.
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PMC9429973
Lille, Inserm, CHU Lille, Centre de Référence des Maladies Autoimmunes Systémiques Rares du Nord et Nord-Ouest de France (CeRAINO), INFINITE – Institute for Translational Research in Inflammation, Lille, France; University of Naples “Federico II”, Naples; University of Eastern Piedmont and AOU “Maggiore della Carità”, Novara, Italy; Incyte Corporation, Wilmington, United States of America; Medical University of Vienna, Vienna, Austria Background: AIHA is a rare condition caused by autoantibody-mediated hemolysis of red blood cells.
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PMC11406030
This resulted in the identification of 20 different LMTK3 binding peptides (LMTK3BPs) that range in size between 11 and 12 amino acids.
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PMC11566417
4The antimicrobial and pro-migratory effects of immortalized, but not primary mammosphere derived epithelial cell (MDEC) conditioned medium (CM) are maintained over time in culture while angiogenic potential is lost in both primary and immortalized MDEC CM.
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PMC11180402
Furthermore, methylation-specific PCR was employed to assess the methylation status of the miR-129 promoter.
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PMC9429973
Aims: The objective of this study is to assess the effectiveness of this neonatal screening for SCD by describing the residual risks of death and major disease-related events during the first fourteen years of life in children diagnosed with SCD at birth in the Netherlands.
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PMC9428827
We previously described a mutein, named no-alpha, with a severe decrease in affinity to CD25 (16).
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PMC11774112
Based on the stability results, it is reasonable to conclude that these complexes can be used in systems for delivering miRNA 34a in vivo.
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PMC11627060
Research indicates that NPs less than 200 nm in size are optimal for internalization by cancer cells, such as the A549 lung cancer cell line.
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PMC9429973
Myocarditis is an inflammatory disease of cardiac muscle caused by a variety of infectious and noninfectious conditions.
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PMC11763111
D The expression of PD-1, LAG3, and TIM-3 was evaluated in unstimulated condition (n = 3).
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PMC9429973
The prognosis of this group was particularly unfavorable with a median overall survival (OS) of 23 months; and a progression-free survival (PFS) of 15 months, even worse than that described for DH-TP53 patients (HR = 1.83 [95% CI, 1.00-3.35], p = 0.046).
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PMC9429973
We observed stronger remodeling on the way to type 2 than to type 1 relapses reflected by more evident changes in methylation, chromatin accessibility and gene expression.
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PMC11574271
Scale bar 1 µm) Experiments in B–H were repeated three times (n = 3).
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PMC11286266
Similar consideration was applied to PRMT8, as the family member PRMT1 has been shown to enhance ATF6α transcriptional activity (Baumeister et al., 2005).
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PMC11495567
Meanwhile, the increase in the levels of phosphorylated RPS6KA1 could lead to the activation of RPS6KA family members, specifically, RPS6KA1 and RPS6KA3 (RSK2), which support cell proliferation and growth while RPS6KA2 (RSK3) and RPS6KA6 (RSK4) play roles in tumor suppression, cell cycle arrest, and apoptosis .
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PMC9587298
Results obtained in Caco-2 cells for 24 h of exposure (Fig. 6a1) showed an IC50 = 3.06 ± 0.05 mM, however concentrations between 0.5 and 2 mM were not cytotoxic (cell viability ∼ 100 % of untreated control) but higher doses of MGO dose-dependently reduces cell viability (Fig. 6a1).
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PMC10055960
Notably, complex 5 was more active in the A2780, A2780cis, and OVCAR-3 cell lines than was observed for carboplatin, which is a commonly used drug in the treatment regime for ovarian cancer.
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PMC11343332
Our results showed that pycnogenol treatment significantly increased the percentage of apoptotic cells, indicating a pro-apoptotic effect.
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PMC10421378
Genomics is a non-invasive method that has also been utilized to identify the proteins associated with adhesion .
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PMC11703896
Rapamycin induces autophagy and apoptosis in cancer cells by the interaction of FKBP12-rapamycin complex with mTORC1 and the mechanism was well reported in the previous research (Zou et al. 2020).
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PMC9219615
Likewise, Fgr is constitutively active in many cancers but is also known for its ROS-dependent activation and promotion of healthy mitochondrial complex II function .
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PMC9784246
The docking score, root mean square deviation (RSMD), and 2D and 3D interactions were recorded.
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PMC11788920
The DNA and RNA products were purified via denaturing polyacrylamide gel electrophoresis (PAGE) with different percentages.
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PMC11332076
A: Schematic diagram of GST-tagged F-iIR (F-iIR-GST) and F-iIGF1R (F-iIGF1R-GST) constructs used in this study.
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PMC6024716
Chinese hamster ovary (CHO) cells are currently the main industrial producers of recombinant therapeutic proteins because of their efficient growth and high expression characteristics.
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