OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC10808409	Cells were harvested from both samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "harvested", "from", "both", "samples", "." ] } ]
PMC11052306	The last example of phosphorus dendrons functionalized with pyridine–imine groups concerns generation zero.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "last", "example", "of", "phosphorus", "dendrons", "f...
PMC11739504	Quantification of the percentage of ciliated cells in Kat2b-depleted cells compared to control shRNA cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantification", "of", "the", "percentage", "of", "ciliated", ...
PMC8584666	Additionally, proliferating cells are maintained in a reduced state.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "proliferating", "cells", "are", "maintained", "in", "a", "reduced", "state"...
PMC9164404	AbPlatin was supposed to release Pt(II) after it entered the cancer cells via chemical reduction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "AbPlatin", "was", "supposed", "to", "release", "Pt(II"...
PMC10878518	Reverse transcription was carried out using the PrimerScript RT Reagent Kit (Takara Bio, Tokyo, Japan) according to the manufacturer’s protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11389534	Both UFBP1 and CDK5RAP3 are possible adaptor proteins that allow the ligase UFL1 to recruit a wider pool of substrates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "UFBP1", "and", ...
PMC9429973	However, data about thrombotic complications in patients with MERS-COV are limited.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "data", "about", "thrombotic", "complications", "in", "patients", ...
PMC10813895	Aging alters breast tissue architecture, with increased adipose cell proportions , basement membrane disruption , and epithelial composition shifts .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aging", "alters", "breast", ...
PMC8427838	Cells were grown in 10-cm culture dishes until 80 to 90% confluence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "grown", "in", "10-cm", "culture", "dishes", "until", ...
PMC9583612	The snapshot measurements include an optical gas imaging (OGI) camera paired with a Hi-Flow Sampler, a drone-based mass balance technology by SeekOps, Inc. (“SeekOps”), an aerial LiDAR plume identification system by Bridger Photonics (“Bridger”).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Survival analysis showed that CD2-LMO2 mice with Tet2 overexpression have an increased latency of T-ALL (Fig. 1D, p=0,03).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Survival", "analysis", ...
PMC11400680	However, our approach consistently delivers better mAP50 scores for medium (54.66%) and difficult (38.29%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "o...
PMC11594074	Aiming to confirm the obtained results, molecular docking using AutoDock 2.4.6 was performed on the top 22 compounds based on PyRx-based virtual screening (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11127909	EFHD1 expression is elevated in OS, causing OS cells to resist drug therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EFHD1", "expression", "is", "elevated", "in", "OS", ",", "causin...
PMC11380329	Values were expressed as the mean ± SEM of at least three independent experiments and represented graphically.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Values", "were", "expressed", "as", "the", ...
PMC11694066	C–F, Dose–response survival curves of the DSRCT cell lines JN1 and R, and the A673 (Ewing sarcoma) and SaOS-2 (osteosarcoma) cell lines exposed to talazoparib (C), olaparib (D), M4344 (E), or AZD6738 (F) for 7 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O"...
PMC9429973	No significant changes in the level of Bacteroides, Firmicutes, and Proteobacteria were found.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "significant", "changes", "in", "the", "level", "of", ...
PMC11594806	AMPK activation by cisplatin (CDDP) is believed to contribute to CDDP’s side effects, such as kidney injury.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "AMPK", "activation", ...
PMC11543853	The membranes and filaments were manually segmented using the Brush tool and masking to select voxels belonging to membranes or microfilaments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "membranes", ...
PMC10218459	This can be attributed to the fact that the sole application of chemotherapy on A673 cells resulted in an almost complete inhibition of cell growth, leaving little space for further improvement.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11224020	This finding prompted us to hypothesize that confinement at a height of 2 µm might compromise nuclear accumulation of cPLA2 due to loss of nuclear envelope integrity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11323699	While most studies have focused on the CD47/signal regulatory protein (SIRP)α interface (the “don’t eat me” signal) , the CD47/TSP-1 axis is gaining attention in the field of oncology because it influences tumor cell survival and cancer stem cell differentiation , supports chemotherapy and radiotherapy resistance , and...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10203589	In pediatric ependymoma studies, FGF18 was predicted to be an ependymoma-associated gene and associated with cell cycle by methylation and expression microarray data analysis (187).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: Preclinical data suggest that high MYC expression impairs anti-tumor immune responses [Casey, Science 2016].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "Preclinical", "data"...
PMC11046454	As indicated by the expression of CD69 and CD25, ATP-AptPTK7-functionalized CAR-T (ATP-AptPTK7-CAR-T) could be activated by target PTK7 231 cells in an ATP-rich environment (Figures 4C and S37), while minimal effect was observed in the absence of ATP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "...
PMC9479186	Last, we did not uncover the exact effect of NDUFC1 on Complex I. Therefore, future research is necessary.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Last", ",", "we", "did...
PMC11348300	In this case, after palpation, the tumor nears complete hypoxia (HS = 0.8), while healthy tissues remain relatively normoxic and re-equilibrate in approximately 30 s. (E) Illustration of dermal and subdermal capillary bed at rest in a murine model. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Most frequent side effects included chills (8%), diarrhea (6%), headache (2%), nausea (2%) and vomiting (2%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9454178	A, B qRT–PCR and immunoblotting analysis of c-KIT expression after siRNA-mediated CDK7 knockdown in GIST-T1 and GIST-882 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "A", "...
PMC10154881	NECTIN4 expression on the surface of E.G‐7/N4 and B16/N4 cells was confirmed by staining with anti‐NECTIN4 antibody and analyzed by flow cytometry (Figure 1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11552389	Western blotting analyzed the nuclear and total FOXN3 expression in melanoma cell lines A357 and A375R.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O" ], "tokens": [ "Western", "blotting", "analyzed", "the", "...
PMC9429973	Although 80% of patients initially achieve a complete remission, the long-term disease-free survival is poor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "80", "%", "of", "patients", "in...
PMC11471157	Human keratinocyte HaCaT cell lines were obtained from CLI (Eppelheim, Germany).	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Human", "keratinocyte", "HaCaT", "cell", "lines", "were", "ob...
PMC9412887	Therefore, there is a pressing need to develop new methods to surmount cancer drug resistance .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "there", "is", "a", "pressing", ...
PMC11772585	Initially, the expression levels of METTL1 and ATF4 in the tumor tissues were examined, revealing a significant enhancement in ATF4 expression in tumors originating from cells harboring the overexpression of ATF4 (Supplementary Fig. S8A–D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11747467	TCGA-MIBC protein expression profile was collected from The Cancer Proteome Atlas (TCPA) database (https://tcpaportal.org/tcpa/).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TCGA-MIBC", "protein", "expression", "profil...
PMC10380508	Using co-transfection experiments, Schwarz et al. showed reciprocal inhibition of promoter/enhancer activity by the respective PAX2 and PAX6 proteins acting on each other’s gene promoters .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9532503	Fig. 3Dose response curve generated by parallel line analysis (PLA) for ADCC activity of test anti-CD20 antibody and control antibody.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "3Dos...
PMC7802142	It is hypothesized that miR-100 might be involved in ReN-NV-induced HF growth.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "hypothesized", "that", "miR-100", "might", "be", "involved", "in", ...
PMC9118379	The general parameters used in de novo peptide sequencing tools were a precursor mass tolerance of ±10 ppm, a fragment mass tolerance of ±0.01 Da, carbamidomethylation of cysteine as a fixed modification, oxidation of methionine as a variable modification, and output of the top 10 rank hits for each spectrum.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11471176	Researchers have discerned a reciprocal interrelation between breast cancer and the novel coronavirus disease 2019 (COVID-19).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Researchers", "have", "discerned", "a", ...
PMC9599726	Except for the ENPP2 gene that was also downregulated in VP-treated GIST48 cells, the other ferroptosis-related DEG genes were not found in the other conditions, suggesting that VP and CA3 do not induce ferroptosis through major common changes in the expression of ferroptosis-related genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543853	PBS was removed by pipetting, and the grids were vitrified using a Vitrobot Mark IV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PBS", "was", "removed", "by", "pipetting", ",", ...
PMC10654497	The total C-index, 95% confidence interval (CI), and P-value of the model were 0.66327, 0.60882–0.71772, and 4.1665, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC8193813	After sampling was completed, the sensors were similarly tested to assess potential drift.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "sampling", "was", "completed", ",", "the", "sensors", "...
PMC11638255	Peripheral blood from consenting male healthy donors (University of New South Wales Human Research Ethics Project Approval Numbers: iRECS0865, HC180299) was collected by venipuncture into K2‐EDTA tubes (BD Biosciences, USA; #366643).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9370419	The extracted DNA samples were resuspended in 20 µL ddH2O.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "extracted", "DNA", "samples", "were", "resuspended", "in", "20", "µL", "ddH2O", "."...
PMC9429973	Long-term follow-up is important to judge both effcacy and safety of this approach.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Long-term", "follow-up", "is", "important", "to", "judge", "both", "effcacy...
PMC7039683	C–E) Genome browser view for regions sharing this feature near RAP2B, KLF4, and PLAU. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "–", "E", ")", ...
PMC9429973	These results demonstrate that the B-Cell MRD Assay is a highly sensitive tool for detecting MRD in B-cell malignancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "demonstrate", ...
PMC9429973	Notably, PPM1D (p<.001) and TP53 (p<.001) were more frequently mutated in the chemo group (Figure C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably...
PMC11629143	However, a major challenge is the instability of transgene expression over long‐term culture, which necessitates costly stability studies .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "a", "m...
PMC10729469	Percent area occupied was quantified using Cavalieri estimator probe.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Percent", "area", "occupied", "was", "quantified", "using", "Cavalieri", "estimator", "probe", "." ] ...
PMC11144200	Despite several CTLA-4 monoclonal antibody drugs have been recommended by the FDA for clinical trials in some cancers, they still face numerous challenges in terms of application such as complex structure, high immunogenicity, non-specifically binds to normal tissues and high production cost .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: The frequencies of heterozygous genotypes FV 1691 GA and FII 20210 GA were 3.8 and 3.5 times higher in DVT patients than in the CG (14.5% vs. 4.4%; OR=3.8; 95% CI: 1.5–9.7; p=0.004 and 5.3% vs. 1.6%; OR=3.5; 95% CI: 0.7–15.6; p=0.098, respectively).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519567	After 5 washes in PBS, one hour of incubation in secondary antibodies (Goat anti-Rabbit IgG (H + L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 568, A11011; Goat anti-Rabbit IgG (H + L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 488, A-11008; Goat anti-Mouse IgG (H + L) Cross-Adsorbed Secondary Antibody, Alexa...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7229095	After the adaptation, CDM2 and CDM3 achieved higher productivity during batch culturing of pools, presumably due to the increased supply of components in these richer media (Table 3).Table 2Evaluation of media performance based on platform mediaMedia candidatesRelative productivity for IgGRelative productivity for reco...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9325715	The cytotoxicity of the obtained complex was evaluated by MTT reduction and LDH release assays on Caco-2 and nL929 cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cytotoxicity", ...
PMC11720808	After blocking with 5% goat serum, cells were incubated with primary antibodies against TLR4 (1:200, Proteintech), TRAF6 (1:100, CST) and NF-κB p65 (1:100, Proteintech) at 4°C overnight, then the cells were incubated with fluorescein-conjugated secondary antibody.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11391695	Following a 15-min immersion in a 0.3% Triton X-100 solution, the cells were subjected to a subsequent 15-min staining step using Hoechst 33258 stain solution at a concentration of 1 µg/mL. In conclusion, a fluorescent microscope (Olympus Corporation, Japan) was utilized to examine the cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11422497	To date, there are no reports on circ_SMA4 (has_circRNA_103870) in the current literature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "date", ",", "there", "are", "no", "reports...
PMC9429973	Event free survival (EFS) was not significantly different (HR:0.91 95%CI: 0.50-1.64, p=0.76).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Event", "free", "survival", ...
PMC9429973	We observed higher rates of MRD-negativity in subjects with a serological response of CR/sCR or better versus VGPR (59% versus 34%, p=0.01), OR=2.8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The 4 groups were analyzed by the Kaplan–Meier method for the survival curves, which MYC+ with transformation associated with worse PFS (Figure 1B, P=0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10914904	However, knockout of MVP in mice did not change dendritic cell migration or antigen presentation, suggesting that MVP could have other roles in the development of dendritic cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10812665	These changes are canonical signs of a reduced TCA flux.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "changes", "are", "canonical", "signs", "of", "a", "reduced", "TCA", "flux", "." ...
PMC9429973	The prospective non-randomized, multicenter phase 2 trial recruited patients in 5 investigational sites in Germany.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "prospective", "non-randomized", ",", "multicenter", ...
PMC11435360	Six-week-old male C57BL/6 mice were purchased from Charles River Canada (St. Constant, QC, Canada) and maintained in the Animal Care and Veterinary Services facility at Western University (London, ON, Canada) under standard conditions.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11696576	While these findings supported the hypothesis that AVX420 initiated cell death via the ATF4 dependent ISR pathway, the absence of translational repression, or selective upregulation of ATF4 translation in response to AVX420, would argue against this, and an alternative mechanism for activation of ATF4 target genes is m...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Two cases showed elevated CD4-CD8- TCR αβ+ T-cells (“double negatives T-cells”).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "cases", "showed", "elevated", "CD4-CD8-", "TCR", "αβ...
PMC10887351	In this work, β3-ARs induced GSH synthesis to maintain GSH homeostasis in glioma cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "work", ",", "β3-ARs", "induced", "GSH", ...
PMC11622247	For comparison, delivery of JK2 into CCRF CEM cells (which express a different TCR) resulted in a lower increase of fluorescence intensity (+68%) and only 12% of the 6 × 10 to 15 × 10 live CCRF CEM cells analyzed exhibited higher than background fluorescence (see Fig. 6A, right for an example and Fig. 6C for averaged d...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC5363531	In particular, in each clone, dasatinib reduced TS promoter mediated luciferase activity at 24 and 48 h. This effect was also confirmed at the TS protein level (A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5308810	An approach that can eliminate rather than antagonize CXCR4 may increase the therapeutic efficacy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "approach", "that", "can", "eliminate", "rather", "than", "...
PMC11699178	This discovery lays a foundation for a deeper understanding of the cellular heterogeneity and complexity of ovarian cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "discovery", "lays", "a", "foun...
PMC9429973	Therefore, the first-step analysis was carried out for 130 patients according “intention-to-treat”.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "the", "first-step", "analysis", "was", "c...
PMC9429973	Methods: We used RNase H-recruiting, locked nucleic acid-modified oligonucleotides (gapmers) for knock-down (KD) experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "We", "...
PMC11765879	The cells remained viable, and there was no significant decrease in the number of cells at the same extract concentrations used (Figure 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11252553	DPPH: 2-diphenyl-1-picrylhydrazyl, RSA: free radical-scavenging activity) As shown in the diagrams, unlike cysteine, Taurine’s DPPH radical scavenging capacity decreases with increasing concentration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9261184	GHG emissions associated with different engine loads for main engine 1 (left) and generator engine (eight cylinder, right), split by the contribution from methane (GWP100) and CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727306	A Synergy HT Multi-Detection Microplate Reader (BioTek, Winooki, VT, USA) was used to analyze the plates with 485/20 nm excitation and fluorescence measured at 528/20 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6312945	Many liver cancers are associated with HBV infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Many", "liver", "cancers", "are", "associated", "with", "HBV", "infection", "." ] } ]
PMC11476264	Studies by Manshouri R et al. have shown that ZEB1 can become a therapeutic target for metastatic NSCLC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Studies", "by", "Manshouri", "R", "et"...
PMC9583612	Because events can last less than 24 hours, high sampling rate technologies like CEMSs will likely be needed to develop these distributions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Because...
PMC9429973	More patients receiving CPX-351 were transplanted (50.5% vs 41.5%) with the median number of courses given prior to transplant 2 in both arms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9268183	In addition, epidemiological studies highlight the positive effects of the ingestion of plants belonging to the genus Brassica as a cancer preventive , providing support to our reports.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6771295	In REN cells, SIRT5 silencing decreased SIRT3 protein levels in untreated, rotenone, and etoposide treated cells (Figure 4Cii, compare bars 1, 2, and 3 to 5, 6, and 7).	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680562	Furthermore, investigating the integration of alternative bioactive chemicals and refining the gel formulation might amplify its therapeutic capacity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "investigating", ...
PMC11261875	Conversely, another study examining the characteristics of small extracellular vesicles derived from GIST cells in the plasma of patients with GIST suggested a correlation between an unfavorable prognosis and elevated carcinoembryonic antigen levels and/or diminished GLUT-1 levels .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	No new safety signals were observed relative to DREAMM-2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "new", "safety", "signals", "were", "observed", "relative", "to", "DREAMM-2", "." ] } ]
PMC9429973	Patients developing this erythroid/megakaryocytic bias showed a trend towards a higher frequency of mutations in genes encoding for spliceosome components (U2AF1, SF3B1 and SRSF2), in particular U2AF1 was found significantly (p-value=0.05) more mutated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9370419	HBV DNA was analyzed using a Diagnostic Kit for Hepatitis B virus DNA (PCR-Fluorescence Probing; Sansure Biotech) following the manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11748363	Microdilution broth method according to EUCAST with minor modifications (European Committee for Antimicrobial Susceptibility Testing [EUCAST] of the European Society of Clinical Microbiology and Infectious Diseases [ESCMID] 2003).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10812665	Data of treated samples are expressed relative to solvent (DMSO) controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "of", "treated", "samples", "are", "expressed", "relative", "to", ...
PMC10968586	HT doses of 100 μM and 200 μM in HepG2 and 80 μM, 100 μM, and 200 μM in Hep3B cells produced an increase in IL-6 release .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "...
PMC10376064	However, the phase III trial was terminated due to severe side effects .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "phase", "III", "trial", "was", "terminated", "...
PMC11599565	In this context, it is noteworthy that the transcriptome analysis of both wildtype and cisplatin-exposed cells revealed the expression of numerous genes associated with the muscle system and morphogenesis. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	89% of patients of the Abroad group, 61% of the Urban and 65% of the Rural received their stem cells from a matched related donor (P=0.047).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790971	a, d Scatter plots illustrate the cross-validated classification performance of the three passages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", ",", "d", "Scatter", "plots", "illustrate", "the", "cross-va...

PMC10808409

Cells were harvested from both samples.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "harvested", "from", "both", "samples", "." ] } ]

PMC11052306

The last example of phosphorus dendrons functionalized with pyridine–imine groups concerns generation zero.

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PMC11739504

Quantification of the percentage of ciliated cells in Kat2b-depleted cells compared to control shRNA cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantification", "of", "the", "percentage", "of", "ciliated", ...

PMC8584666

Additionally, proliferating cells are maintained in a reduced state.

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PMC9164404

AbPlatin was supposed to release Pt(II) after it entered the cancer cells via chemical reduction.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "AbPlatin", "was", "supposed", "to", "release", "Pt(II"...

PMC10878518

Reverse transcription was carried out using the PrimerScript RT Reagent Kit (Takara Bio, Tokyo, Japan) according to the manufacturer’s protocol.

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PMC11389534

Both UFBP1 and CDK5RAP3 are possible adaptor proteins that allow the ligase UFL1 to recruit a wider pool of substrates.

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PMC9429973

However, data about thrombotic complications in patients with MERS-COV are limited.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "data", "about", "thrombotic", "complications", "in", "patients", ...

PMC10813895

Aging alters breast tissue architecture, with increased adipose cell proportions , basement membrane disruption , and epithelial composition shifts .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aging", "alters", "breast", ...

PMC8427838

Cells were grown in 10-cm culture dishes until 80 to 90% confluence.

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PMC9583612

The snapshot measurements include an optical gas imaging (OGI) camera paired with a Hi-Flow Sampler, a drone-based mass balance technology by SeekOps, Inc. (“SeekOps”), an aerial LiDAR plume identification system by Bridger Photonics (“Bridger”).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Survival analysis showed that CD2-LMO2 mice with Tet2 overexpression have an increased latency of T-ALL (Fig. 1D, p=0,03).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Survival", "analysis", ...

PMC11400680

However, our approach consistently delivers better mAP50 scores for medium (54.66%) and difficult (38.29%).

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PMC11594074

Aiming to confirm the obtained results, molecular docking using AutoDock 2.4.6 was performed on the top 22 compounds based on PyRx-based virtual screening (Table 1).

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PMC11127909

EFHD1 expression is elevated in OS, causing OS cells to resist drug therapy.

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PMC11380329

Values were expressed as the mean ± SEM of at least three independent experiments and represented graphically.

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PMC11694066

C–F, Dose–response survival curves of the DSRCT cell lines JN1 and R, and the A673 (Ewing sarcoma) and SaOS-2 (osteosarcoma) cell lines exposed to talazoparib (C), olaparib (D), M4344 (E), or AZD6738 (F) for 7 days.

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PMC9429973

No significant changes in the level of Bacteroides, Firmicutes, and Proteobacteria were found.

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PMC11594806

AMPK activation by cisplatin (CDDP) is believed to contribute to CDDP’s side effects, such as kidney injury.

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PMC11543853

The membranes and filaments were manually segmented using the Brush tool and masking to select voxels belonging to membranes or microfilaments.

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PMC10218459

This can be attributed to the fact that the sole application of chemotherapy on A673 cells resulted in an almost complete inhibition of cell growth, leaving little space for further improvement.

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PMC11224020

This finding prompted us to hypothesize that confinement at a height of 2 µm might compromise nuclear accumulation of cPLA2 due to loss of nuclear envelope integrity.

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PMC11323699

While most studies have focused on the CD47/signal regulatory protein (SIRP)α interface (the “don’t eat me” signal) , the CD47/TSP-1 axis is gaining attention in the field of oncology because it influences tumor cell survival and cancer stem cell differentiation , supports chemotherapy and radiotherapy resistance , and...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10203589

In pediatric ependymoma studies, FGF18 was predicted to be an ependymoma-associated gene and associated with cell cycle by methylation and expression microarray data analysis (187).

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PMC9429973

Aims: Preclinical data suggest that high MYC expression impairs anti-tumor immune responses [Casey, Science 2016].

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PMC11046454

As indicated by the expression of CD69 and CD25, ATP-AptPTK7-functionalized CAR-T (ATP-AptPTK7-CAR-T) could be activated by target PTK7 231 cells in an ATP-rich environment (Figures 4C and S37), while minimal effect was observed in the absence of ATP.

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PMC9479186

Last, we did not uncover the exact effect of NDUFC1 on Complex I. Therefore, future research is necessary.

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PMC11348300

In this case, after palpation, the tumor nears complete hypoxia (HS = 0.8), while healthy tissues remain relatively normoxic and re-equilibrate in approximately 30 s. (E) Illustration of dermal and subdermal capillary bed at rest in a murine model. (

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PMC9429973

Most frequent side effects included chills (8%), diarrhea (6%), headache (2%), nausea (2%) and vomiting (2%).

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PMC9454178

A, B qRT–PCR and immunoblotting analysis of c-KIT expression after siRNA-mediated CDK7 knockdown in GIST-T1 and GIST-882 cells.

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PMC10154881

NECTIN4 expression on the surface of E.G‐7/N4 and B16/N4 cells was confirmed by staining with anti‐NECTIN4 antibody and analyzed by flow cytometry (Figure 1B).

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PMC11552389

Western blotting analyzed the nuclear and total FOXN3 expression in melanoma cell lines A357 and A375R.

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PMC9429973

Although 80% of patients initially achieve a complete remission, the long-term disease-free survival is poor.

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PMC11471157

Human keratinocyte HaCaT cell lines were obtained from CLI (Eppelheim, Germany).

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PMC9412887

Therefore, there is a pressing need to develop new methods to surmount cancer drug resistance .

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PMC11772585

Initially, the expression levels of METTL1 and ATF4 in the tumor tissues were examined, revealing a significant enhancement in ATF4 expression in tumors originating from cells harboring the overexpression of ATF4 (Supplementary Fig. S8A–D).

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PMC11747467

TCGA-MIBC protein expression profile was collected from The Cancer Proteome Atlas (TCPA) database (https://tcpaportal.org/tcpa/).

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PMC10380508

Using co-transfection experiments, Schwarz et al. showed reciprocal inhibition of promoter/enhancer activity by the respective PAX2 and PAX6 proteins acting on each other’s gene promoters .

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PMC9532503

Fig. 3Dose response curve generated by parallel line analysis (PLA) for ADCC activity of test anti-CD20 antibody and control antibody.

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PMC7802142

It is hypothesized that miR-100 might be involved in ReN-NV-induced HF growth.

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PMC9118379

The general parameters used in de novo peptide sequencing tools were a precursor mass tolerance of ±10 ppm, a fragment mass tolerance of ±0.01 Da, carbamidomethylation of cysteine as a fixed modification, oxidation of methionine as a variable modification, and output of the top 10 rank hits for each spectrum.

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PMC11471176

Researchers have discerned a reciprocal interrelation between breast cancer and the novel coronavirus disease 2019 (COVID-19).

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PMC9599726

Except for the ENPP2 gene that was also downregulated in VP-treated GIST48 cells, the other ferroptosis-related DEG genes were not found in the other conditions, suggesting that VP and CA3 do not induce ferroptosis through major common changes in the expression of ferroptosis-related genes.

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PMC11543853

PBS was removed by pipetting, and the grids were vitrified using a Vitrobot Mark IV.

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PMC10654497

The total C-index, 95% confidence interval (CI), and P-value of the model were 0.66327, 0.60882–0.71772, and 4.1665, respectively.

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PMC8193813

After sampling was completed, the sensors were similarly tested to assess potential drift.

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PMC11638255

Peripheral blood from consenting male healthy donors (University of New South Wales Human Research Ethics Project Approval Numbers: iRECS0865, HC180299) was collected by venipuncture into K2‐EDTA tubes (BD Biosciences, USA; #366643).

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PMC9370419

The extracted DNA samples were resuspended in 20 µL ddH2O.

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PMC9429973

Long-term follow-up is important to judge both effcacy and safety of this approach.

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PMC7039683

C–E) Genome browser view for regions sharing this feature near RAP2B, KLF4, and PLAU. (

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PMC9429973

These results demonstrate that the B-Cell MRD Assay is a highly sensitive tool for detecting MRD in B-cell malignancies.

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PMC9429973

Notably, PPM1D (p<.001) and TP53 (p<.001) were more frequently mutated in the chemo group (Figure C).

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PMC11629143

However, a major challenge is the instability of transgene expression over long‐term culture, which necessitates costly stability studies .

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PMC10729469

Percent area occupied was quantified using Cavalieri estimator probe.

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PMC11144200

Despite several CTLA-4 monoclonal antibody drugs have been recommended by the FDA for clinical trials in some cancers, they still face numerous challenges in terms of application such as complex structure, high immunogenicity, non-specifically binds to normal tissues and high production cost .

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PMC9429973

Results: The frequencies of heterozygous genotypes FV 1691 GA and FII 20210 GA were 3.8 and 3.5 times higher in DVT patients than in the CG (14.5% vs. 4.4%; OR=3.8; 95% CI: 1.5–9.7; p=0.004 and 5.3% vs. 1.6%; OR=3.5; 95% CI: 0.7–15.6; p=0.098, respectively).

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PMC11519567

After 5 washes in PBS, one hour of incubation in secondary antibodies (Goat anti-Rabbit IgG (H + L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 568, A11011; Goat anti-Rabbit IgG (H + L) Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 488, A-11008; Goat anti-Mouse IgG (H + L) Cross-Adsorbed Secondary Antibody, Alexa...

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PMC7229095

After the adaptation, CDM2 and CDM3 achieved higher productivity during batch culturing of pools, presumably due to the increased supply of components in these richer media (Table 3).Table 2Evaluation of media performance based on platform mediaMedia candidatesRelative productivity for IgGRelative productivity for reco...

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PMC9325715

The cytotoxicity of the obtained complex was evaluated by MTT reduction and LDH release assays on Caco-2 and nL929 cell lines.

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PMC11720808

After blocking with 5% goat serum, cells were incubated with primary antibodies against TLR4 (1:200, Proteintech), TRAF6 (1:100, CST) and NF-κB p65 (1:100, Proteintech) at 4°C overnight, then the cells were incubated with fluorescein-conjugated secondary antibody.

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PMC11391695

Following a 15-min immersion in a 0.3% Triton X-100 solution, the cells were subjected to a subsequent 15-min staining step using Hoechst 33258 stain solution at a concentration of 1 µg/mL. In conclusion, a fluorescent microscope (Olympus Corporation, Japan) was utilized to examine the cells.

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PMC11422497

To date, there are no reports on circ_SMA4 (has_circRNA_103870) in the current literature.

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PMC9429973

Event free survival (EFS) was not significantly different (HR:0.91 95%CI: 0.50-1.64, p=0.76).

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PMC9429973

We observed higher rates of MRD-negativity in subjects with a serological response of CR/sCR or better versus VGPR (59% versus 34%, p=0.01), OR=2.8).

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PMC9429973

The 4 groups were analyzed by the Kaplan–Meier method for the survival curves, which MYC+ with transformation associated with worse PFS (Figure 1B, P=0.001).

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PMC10914904

However, knockout of MVP in mice did not change dendritic cell migration or antigen presentation, suggesting that MVP could have other roles in the development of dendritic cells .

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PMC10812665

These changes are canonical signs of a reduced TCA flux.

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PMC9429973

The prospective non-randomized, multicenter phase 2 trial recruited patients in 5 investigational sites in Germany.

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PMC11435360

Six-week-old male C57BL/6 mice were purchased from Charles River Canada (St. Constant, QC, Canada) and maintained in the Animal Care and Veterinary Services facility at Western University (London, ON, Canada) under standard conditions.

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PMC11696576

While these findings supported the hypothesis that AVX420 initiated cell death via the ATF4 dependent ISR pathway, the absence of translational repression, or selective upregulation of ATF4 translation in response to AVX420, would argue against this, and an alternative mechanism for activation of ATF4 target genes is m...

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PMC9429973

Two cases showed elevated CD4-CD8- TCR αβ+ T-cells (“double negatives T-cells”).

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PMC10887351

In this work, β3-ARs induced GSH synthesis to maintain GSH homeostasis in glioma cells .

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PMC11622247

For comparison, delivery of JK2 into CCRF CEM cells (which express a different TCR) resulted in a lower increase of fluorescence intensity (+68%) and only 12% of the 6 × 10 to 15 × 10 live CCRF CEM cells analyzed exhibited higher than background fluorescence (see Fig. 6A, right for an example and Fig. 6C for averaged d...

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PMC5363531

In particular, in each clone, dasatinib reduced TS promoter mediated luciferase activity at 24 and 48 h. This effect was also confirmed at the TS protein level (A).

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PMC5308810

An approach that can eliminate rather than antagonize CXCR4 may increase the therapeutic efficacy.

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PMC11699178

This discovery lays a foundation for a deeper understanding of the cellular heterogeneity and complexity of ovarian cancer.

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PMC9429973

Therefore, the first-step analysis was carried out for 130 patients according “intention-to-treat”.

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PMC9429973

Methods: We used RNase H-recruiting, locked nucleic acid-modified oligonucleotides (gapmers) for knock-down (KD) experiments.

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PMC11765879

The cells remained viable, and there was no significant decrease in the number of cells at the same extract concentrations used (Figure 3).

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PMC11252553

DPPH: 2-diphenyl-1-picrylhydrazyl, RSA: free radical-scavenging activity) As shown in the diagrams, unlike cysteine, Taurine’s DPPH radical scavenging capacity decreases with increasing concentration.

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PMC9261184

GHG emissions associated with different engine loads for main engine 1 (left) and generator engine (eight cylinder, right), split by the contribution from methane (GWP100) and CO2.

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PMC11727306

A Synergy HT Multi-Detection Microplate Reader (BioTek, Winooki, VT, USA) was used to analyze the plates with 485/20 nm excitation and fluorescence measured at 528/20 nm.

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PMC6312945

Many liver cancers are associated with HBV infection.

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PMC11476264

Studies by Manshouri R et al. have shown that ZEB1 can become a therapeutic target for metastatic NSCLC.

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PMC9583612

Because events can last less than 24 hours, high sampling rate technologies like CEMSs will likely be needed to develop these distributions.

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PMC9429973

More patients receiving CPX-351 were transplanted (50.5% vs 41.5%) with the median number of courses given prior to transplant 2 in both arms.

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PMC9268183

In addition, epidemiological studies highlight the positive effects of the ingestion of plants belonging to the genus Brassica as a cancer preventive , providing support to our reports.

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PMC6771295

In REN cells, SIRT5 silencing decreased SIRT3 protein levels in untreated, rotenone, and etoposide treated cells (Figure 4Cii, compare bars 1, 2, and 3 to 5, 6, and 7).

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PMC11680562

Furthermore, investigating the integration of alternative bioactive chemicals and refining the gel formulation might amplify its therapeutic capacity.

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PMC11261875

Conversely, another study examining the characteristics of small extracellular vesicles derived from GIST cells in the plasma of patients with GIST suggested a correlation between an unfavorable prognosis and elevated carcinoembryonic antigen levels and/or diminished GLUT-1 levels .

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PMC9429973

No new safety signals were observed relative to DREAMM-2.

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PMC9429973

Patients developing this erythroid/megakaryocytic bias showed a trend towards a higher frequency of mutations in genes encoding for spliceosome components (U2AF1, SF3B1 and SRSF2), in particular U2AF1 was found significantly (p-value=0.05) more mutated.

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PMC9370419

HBV DNA was analyzed using a Diagnostic Kit for Hepatitis B virus DNA (PCR-Fluorescence Probing; Sansure Biotech) following the manufacturer’s instructions.

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PMC11748363

Microdilution broth method according to EUCAST with minor modifications (European Committee for Antimicrobial Susceptibility Testing [EUCAST] of the European Society of Clinical Microbiology and Infectious Diseases [ESCMID] 2003).

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PMC10812665

Data of treated samples are expressed relative to solvent (DMSO) controls.

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PMC10968586

HT doses of 100 μM and 200 μM in HepG2 and 80 μM, 100 μM, and 200 μM in Hep3B cells produced an increase in IL-6 release .

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PMC10376064

However, the phase III trial was terminated due to severe side effects .

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PMC11599565

In this context, it is noteworthy that the transcriptome analysis of both wildtype and cisplatin-exposed cells revealed the expression of numerous genes associated with the muscle system and morphogenesis. (

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PMC9429973

89% of patients of the Abroad group, 61% of the Urban and 65% of the Rural received their stem cells from a matched related donor (P=0.047).

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PMC11790971

a, d Scatter plots illustrate the cross-validated classification performance of the three passages.

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