OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC6461034	Imatinib, which targets ABL, a kinase ranking low by INKA for the CRC PDX models and organoids, was used as negative control and indeed showed negligible inhibition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9065483	Vanadate has been previously established to sustain EGFR activation and its downstream signaling (Figure 1D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Vanadate", "has", "been", "previously", "establis...
PMC11612315	This finding indicates that exendin 20–29 does not activate GLP-1R (Supplementary Fig. 8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "finding", "indicates", "that", "exendin", "20–29", "does", ...
PMC11476666	Proteins related to stemness were investigated by Western blotting, as described previously , using the following primary antibodies: anti-CD44 (Invitrogen, Waltham, MA, USA, 8E2F3, 1:1000), anti-β-Actin (Invitrogen, MA5-15739 1:5000), anti-SOX2 (Abcam, Cambridge, UK, ab97959 1:1000), anti-Oct4 (Abcam, ab19857, 1:1000)...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11756514	In this study, we examined the recognition of various phenotypes of S. aureus by the CTLs MGL, langerin, MBL, and SP-D and explored the influence of CP and WTA on this interaction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11746948	DESeq2 provide statistical routines for determining differential expression in digital gene expression data using a model based on the negative binomial distribution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DESeq2", "pr...
PMC11687663	Proline and glycine residues are depicted as triangles, with 9 and 10 occurrences, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proline", "and", "glycine", "residues", "are", "depict...
PMC11615218	Regulatory T cells (TREG) play an essential role in maintaining immune homeostasis and self-tolerance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Regulatory", "T", "cells", "(", "TREG", ")", "pl...
PMC11371747	Regarding modulation of 5FU, we used several CRC cell lines, previously characterized for their sensitivity to 5FU and the modulation by dl-LV (Van Triest et al., 1999).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10938377	Diffraction data were indexed, integrated, merged, scaled and evaluated with a combination of iMosflm, XDS, autoPROC, SCALA, and AIMLESS from the CCP4 package and in-house data processing pipelines, go.com and go.py, developed by the Swiss Light Source macromolecular crystallography beamlines (Paul Scherrer Institute, ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11474209	Electrochemical immunosensors with conductive nanobiochar paperEnvironmental water0.017 μg/LCoating filter paper with highly conductive and dispersible nBC and anti-MCLR antibodies by dipping-drying created the paper immunosensor.ctDNA on gold electrodeLocal water bodies1.4 ng/LImmobilizing ctDNA on gold electrodes cre...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	To simulate the MM situation with an in vitro model, the magnetically GFPLucNCI-H929 was inoculated as MET into 6-well plate, cell islands were formulated under according tiny magnetisms, then MENK was added to observe its treatment effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: Median Hb concentration(g/dl) was at 4wks 9.5inA,8.6inB,8.8inC,at8wks 10.9inA,10.7inB,10inC,at 12wks 12.3inA,12.5inB,10.5inC. Median ferritin level(ng/ml) was at 0mo inA3,inB10,inC7;at3mo inA20,inB10,inC3;at6mo inA150,inB300,inC70.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11655536	Moreover, although studies are reporting the toxicity profiles and pharmacokinetics of HA with pre-clinical models [30–32], the safety and efficacy of HA need to be further explored in humans with phase I and II clinical trials, especially for the treatment of hematological diseases including MM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11718274	The ROS-mediated mitochondrial pathway of apoptosis in Y2O3NPs treated A-431 cancer cells was further confirmed through the noticed significant increases in the expression of the apoptotic gene p53 in conjunction with significant decreases in the expression of the anti-apoptotic gene Bcl2 because overexpression of the ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11720808	Data are represented as the mean ± SD (n=5). **	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "represented", "as", "the", "mean", "±", "SD", "(", ...
PMC4355729	The PCR product was purified and cloned into pSin-GFP-vector to obtain Psin-GFP-PIK3R1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "PCR", "product", "was", "purified", "and", "cloned", "into", "pSin-GFP-ve...
PMC11772449	White and Dipaola 2009; Shintani and Klionsky 2004).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "White", "and", "Dipaola", "2009", ";", "Shintani", "and", "Klionsky", "2004", ")", "." ...
PMC11225860	depicts H&E stain from a vehicle control treated mouse.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "depicts", "H&E", "stain", "from", "a", "vehicle", "control", "treated", "mouse", "." ] } ]
PMC11519077	The other proinflammatory cytokine upregulated by antigen-presenting cells in the intestinal tissue of CD patients is IL-12, which activates Type 1 helper T (Th1) cells to mediate the inflammatory response [84–86].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Day 60 mortality was 0%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Day", "60", "mortality", "was", "0", "%", "." ] } ]
PMC11615743	Afterward, all these strands were mixed together at a final concentration of 1 nM for each component in D‐PBS supplemented with 12.5 mM MgCl2 to form an AND logic device at 4 °C for 30 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705067	However, FDX1 and DLAT genes are highly correlated with immune checkpoints, which result in favorable patient responses to immune checkpoint therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However...
PMC10706275	After 48 h of culture, the cells were selected under 10 µg/mL puromycin pressure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "48", "h", "of", "culture", ",", "the", "cell...
PMC11617590	These data suggest that SFN inhibits cMyc through inhibition of GSK‐3β and NF‐κB p65.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "suggest", "that", "SFN", "inhibits", "cMyc", "t...
PMC9429973	We included all the cases of DLBCL diagnosed in University Hospital of Sfax between 2008-2019 that were refractory and/or relapsed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "includ...
PMC11612626	HeLa cells (ATCC) were cultured in complete DMEM supplemented with 10% FBS.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HeLa", "cells", "(", "ATCC", ")", "were", "culture...
PMC11429241	With optimization of the fabrication process, 3D culture scaffolds can bring reproducibility to spheroid generation and ensure their adaptability for drug testing .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", ...
PMC11621493	To compare transacylase and hydrolase activity, we determined time-dependent hydrolysis of the preferred phospholipid substrate PE in time-course experiments revealing a specific activity of 17.2 μmol/(mg∙h) (supplemental Fig. S2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11172027	However, it is hardly known at what dose and for how long the treatment with selenium should last in order to ensure that there is an antioxidant protective effect, e.g., in glutathione peroxidase, on the one hand and to positively influence the development or cell growth of cancer via other non-apoptotic mechanisms on...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7841067	Our results suggest that AKAP4 is involved in the carcinogenesis and development of thyroid cancer and may serve as a potential therapeutic target for the treatment of thyroid cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11252033	Briefly, for each cell line, an experimental triplicate was analyzed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "for", "each", "cell", "line", ",", "an", "experimental", "...
PMC9429973	DHODH catalyzes the oxidation of DHO to orotic acid and is a rate-limiting enzyme in de novo pyrimidine nucleotide synthesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DHODH", "catalyzes", "the", ...
PMC11741906	Additionally, we performed survival analysis to validate the potential clinical applicability of these miRNAs using data from ovarian cancer patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", ...
PMC11486946	Single-molecule images of EGFR showed brighter and larger fluorescent spots were increased as the EGF concentration increased.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Single-molecule", "images", "of", "EGFR", "showed...
PMC6442998	Slides were washed in TBS and incubated at RT for 1 hour in TBS containing the secondary antibodies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Slides", "were", "washed", "in", "TBS"...
PMC11347429	For example, Bermejo-Martin et al. (19) observed impaired expression of several genes participating in the T cell and B cell immune responses in patients with severe influenza (patients requiring mechanical ventilation) compared to patients with reduced severity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11538390	Data were presented as mean ± s.d.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "presented", "as", "mean", "±", "s.d", "." ] } ]
PMC11525028	Overexpression of ATF4, ASNS, or Asn supplementation significantly attenuated the impairment of tumor growth (Figure 5G) and resulted in shorter survival (Figure 5H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10380508	Renal cell carcinoma (RCC) is the most common type of kidney malignancy, accounting for approximately 85% of kidney cancer cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11704135	H-NMR spectrum (CDCl3) of compound 13 illustrated (s, 6H, pyrimidine methyl protons) at 2.50, (s, 1H, aromatic protons of pyrimidine ring) at 7.54 and (m, 5H, aromatic protons) at 7.47–7.92 ppm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8041314	Figure 3B summarizes the virtual screening processes of C@PA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "3B", "summarizes", "the", "virtual", "screening", "processes", "of", "C@PA", "." ] } ]
PMC11525028	Xie et al. reported that NAT10 regulated the chemoresistance of bladder cancer through ac4C modification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Xie", "et", "al.", "reported", "that", "NAT10", "regulated"...
PMC9341513	An emerging feature of the model is that clusters of proteins form at positions where there are bridges between DHSs, and that in most cases where a promoter is bound by a protein, it belongs to one of these clusters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11621493	Lipids were analyzed by HPLC-MS 48 h posttransfection. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lipids", "were", "analyzed", "by", "HPLC-MS", "48", "h", "posttransfection", ".", "(" ] } ]
PMC11700165	Nuclear and cytoplasmic fractionation was done by using a fractionation reagent from Thermo Scientific.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nuclear", "and", "cytoplasmic", "fractionation", "was", "done", "by", ...
PMC10582049	For correlation analysis, we used Pearson correlation coefficient.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "correlation", "analysis", ",", "we", "used", "Pearson", "correlation", "coefficient", "." ] } ...
PMC10729469	However, polyclonal Treg treatments rely on the bystander effect from Tregs homing into different tissues in an antigen-independent fashion resulting in global immune suppression .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Summary/Conclusion: The utility of mutational profiling may facilitate the identification of potential drug targets, which in turns may represent new therapeutic possibilities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC6442998	Clinicopathological features are given in Supplementary Tables 4 and 5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinicopathological", "features", "are", "given", "in", "Supplementary", "Tables", "4", "and", "...
PMC11676169	After compiling and filtering the data (proteins representing a fold change (FC) ≥ 10 compared to control, p-value ≤ 0.05 in replicates), the protein list was queried on the Kyoto Encyclopedia of Genes and Genomes (KEGG) and hallmark gene sets using ShinyGO software to identify enriched pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7812570	A Diagram of the lentiviral transfer vector expressing GPI-anchored antibodies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "Diagram", "of", "the", "lentiviral", "transfer", "vector", "expressing", "GPI-anchored", "a...
PMC11635519	The cells were then sent through a 40 μm filter to remove large clumps and loaded into either a FACScan Flow Cytometer (BD Bioscience) for cell analysis or a FACSVantage SE cell sorter (BD Bioscience) for cell sorting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6182045	Here we report: (1) the screening and selection of a clade C gp120 (TZ97008) with improved ability to bind a panel of bNAbs, (2) the development of a stable, high expressing (>1g/L) MGAT1 CHO cell line that limits N-linked glycosylation for improved binding to glycan dependent bNAbs, (3) the development of an improved ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10938336	These results revealed that both compounds 2 and 4 induced apoptosis in the promyelocytic leukemic cell line (HL-60) after 24 h treatment. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11738017	The contribution of mBCMA to TCE activity is evident at a low E:T ratio (Figure 3H, left panel) when comparing GSI-treated OPM2 with OPM2_BCMA cells in which case, despite having similar sBCMA levels after GSI treatment, the higher mBCMA in OPM2_BCMA cells led to an improved TCE cytolytic effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellL...
PMC11509224	The clerodane diterpene, named raspadiene (146, Figure 13), was isolated from the marine sponge Raspailia bouryesnaultae collected in South Brazil .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8303372	Based on the obtained results, all following experiments were carried out using the moderately toxic concentration (500 µmol/L GA) and a slightly toxic concentration (200 µmol/L GA) for both formulations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11489351	A, glycolytic pathway genes with transcripts that were upregulated (magenta) or downregulated (cyan) at low pHi (EIPA, left) or high pHi (NH4Cl, right) compared to the control (MetaCore pathway analysis; see Methods).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8557138	As angiogenesis is a prerequisite for solid tumors to grow and metastasize, a variety of tumor angiogenesis models have been formulated to better understand the underlying mechanisms and associated clinical applications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10944868	Where, the compound DTA0100 (Figure 1) clearly induced microtubule depolymerization, leading to disturbance of cell cycle kinetics and subsequent apoptosis (Podolski-Renić et al., 2017).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11779605	Our next validation step was to compare FGF7 protein levels in surgically collected tumor specimens with ascites specimens from patients with ovarian cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", ...
PMC11476666	Furthermore, preclinical studies in animal and clinical models have demonstrated that RSV, when combined with standard chemotherapy drugs, enhances therapeutic efficacy by sensitizing tumor cells to the effects of chemotherapeutics and overcoming multi-drug resistance, although some side effects, such as diarrhea, naus...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8875242	Both incubation steps were conducted in a humidified atmosphere of 80% O2 and 5% CO2 at 37 °C .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "incubation", ...
PMC8633974	Cholesterol provided stability to the LNPs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cholesterol", "provided", "stability", "to", "the", "LNPs", "." ] } ]
PMC8041314	While 1,2,5-oxadiazoles have frequently been reported as (selective or dual) ABCB1 and ABCC1 inhibitors, 1,2,4-oxadiazoles have only once been reported as selective ABCG2 inhibitors or reversers of ABCB1-, ABCC1-, or ABCG2-mediated MDR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11222184	SYBR green master mix (330500) and Human Cancer Pathway Finder™ PCR array (PAHS-033Z) was obtained from Qiagen.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SYBR", "gree...
PMC11392912	The image shows the relative intensity of the DCFDA cellular ROS in RAFLS in different UT, VC, NC+TNF, and Clo-14+TNF groups. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11705630	Various oncogenes such as mutant KRAS, PI3K, and MYC involved in the nucleotide synthesis pathways have been discovered 42-44.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11228511	NM ruptures occurred more frequently in progerin-expressing cells with an abnormal meshwork, suggesting that the irregularities and large openings in the meshwork weakened the nuclear lamina and were causally related to the emergence of NM ruptures and blebs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711347	The melting point, ranging from 226–228, suggests that the Ni(II)ProDtc complex is pure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "melting", "point", ",", "ranging", "from", "226–228"...
PMC10196713	Similar results were obtained in A2780 cells, where upregulated mitochondrial membrane potential and lipid peroxidation by cisplatin could be suppressed by treatment with rotenone (Fig. S4A and B).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11552389	Time-lapse curve were generated with zencell-owl software (version 3.3, innoME GmbH), and analysed using their built-in algorithms of relative cell coverage, proportion of detached cells, and total cell numbers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Summary/Conclusion: We have shown that EZH2i is not suitable in combination with the common chemotherapeutic Oxaliplatin in T-cell neoplasms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "W...
PMC9429973	In addition, we observed similar cancer-specific H3K4me3-BDs associated with super-enhancer hijacking of other common oncogenes in B-cell (MAF, MYC and FGFR3/NSD2) and T-cell malignancies (LMO2, TLX3 and TAL1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10965680	Genetic structure of the 7 goat breeds. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Genetic", "structure", "of", "the", "7", "goat", "breeds", ".", "(" ] } ]
PMC11676670	Cells were detached using 0.05% trypsin, washed three times with PBS, and fixed with 4% paraformaldehyde (Sigma-Aldrich, St. Louis, MO, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10545062	To address this, we incorporated smaller and more modular fluid-based interventions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "address", "this", ",", "we", "incorporated", "smaller", "and", "more", ...
PMC6889484	These results confirmed that the A3x3G(DK) lentivector can efficiently transduce activated CD4 T cells and CD34 HSPCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "confirmed", "that", ...
PMC9275501	Due to the hydrophobicity of CPT and the hydrophilicity of GEM, the prepared amphiphilic prodrug CPT-SS-GEM can self-assemble into organized nanoparticles to realize the self-delivery of CPT and GEM without additional materials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11750712	However, physiological replacement, topical and inhaled steroids are permitted; cytotoxic chemotherapies within 2 weeks before leukapheresis or AUTO4 infusion; antibody therapy use within 2 weeks before AUTO4 infusion, or five half-lives of the respective antibody, whichever is longer; live vaccine within 4 weeks befor...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Here, we report further long-term safety, tolerability, and effectiveness of BCX9930.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ",", "we", "report", "further", "long-term", "safety", ",...
PMC11190538	The cells were grown at 37 °C in a humidified atmosphere of 5 % CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "grown", "at", "37", "°",...
PMC11697189	However, due to the insensitivity of ccRCC to radiotherapy and chemotherapy, the mortality and recurrence rate of ccRCC are still very high.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11635087	For both whole cells and isolated chloroplasts, the chlorophyll fluorescence yield decreased regardless of whether they were treated with DCMU (Fig. 2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Mean delta liver iron content after esomeprazole treatment was -0.57mg Fe/g dw (SD 1.20; N=24) versus -0.11 (SD 0.75; N=23) after placebo treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10123657	Cellular interactions within the bone marrow microenvironment modulate the properties of subsets of leukemic cells leading to the development of drug-resistant phenotypes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cellular", "...
PMC10870498	Besides, overexpression of KIF23 promoted the viability and migration of 8505C and BCPAP cells, which was partly blocked by silenced SIRT7.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens"...
PMC11495567	The transwell invasion assay was used to determine the PCAIs effects on cell invasion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "transwell", "invasion", "assay", "was", "used", "to", "de...
PMC9000591	These compounds included calycosin , liquiritigenin , and ergosterol peroxide in SE4; pinoresinol in SE2; and maackiain and medicarpin in SE1 and SE2, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11489351	Scale bars represent 20 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", "represent", "20", "μm", "." ] } ]
PMC9429973	Interestingly, the taxonomic comparison revealed a significantly higher relative abundance of butyrate producer groups as Butyricicoccaceae (p=0.008), Clostridiaceae (p=0.009) and Oscillopiraceae (p=0.042) families in responders (Fig 1C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11402217	Scale bars = 10 μM ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", "=", "...
PMC9599726	Before use, 1 μL of 30% H2O2 (Thermo Fisher Scientific, MA, United States, Cat# 241022500) was added to the DAB-Ni solution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11682525	The hair follicles were then cut into several pieces and explanted onto collagen-coated cell culture plates, following previously described procedures ( 11 , 12 ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC8956657	Numbers next to nodes indicate bootstrap proportion support, and the scale indicates the number of nucleotide substitutions per site.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Numbers", "next", "to", ...
PMC11655536	In other cases, LMP and cathepsin release are involved in the activation of effectors such as ROS, Bax, and iron, leading to other types of cell death, such as apoptosis, pyroptosis, and ferroptosis [25–27].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6642070	Insert is the average normalized to control in baseline. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Insert", "is", "the", "average", "normalized", "to", "control", "in", "baseline", ".", "("...
PMC11092418	Protein samples (25 µg) were separated on 4-12% Bis-Tris gel (Invitrogen; Thermo Fisher Scientific, Inc.) using the Xcell II Surelock Mini-Cell system (Invitrogen; Thermo Fisher Scientific, Inc.) and transferred onto immobilon-polyvinylidene fluoride (FL PVDF) membranes (Merck), using Xcell II Mini-Cell Blot Module kit...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9587298	The electron charges for cyanidin, cyanidin-3-O-glucoside, cyanidin-3,5-O-diglucoside, cyanidin-3-O-sambubioside, cyanidin-3-O-sambubioside-5-O-glucoside in the flavylium cation form and carbinol pseudo-base form (hemiketal) and quercetin, quercetin-3-O-glucoside, quercetin-3-O-rutinoside, caffeic acid (dissociated) an...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6461034

Imatinib, which targets ABL, a kinase ranking low by INKA for the CRC PDX models and organoids, was used as negative control and indeed showed negligible inhibition.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9065483

Vanadate has been previously established to sustain EGFR activation and its downstream signaling (Figure 1D).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Vanadate", "has", "been", "previously", "establis...

PMC11612315

This finding indicates that exendin 20–29 does not activate GLP-1R (Supplementary Fig. 8).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "finding", "indicates", "that", "exendin", "20–29", "does", ...

PMC11476666

Proteins related to stemness were investigated by Western blotting, as described previously , using the following primary antibodies: anti-CD44 (Invitrogen, Waltham, MA, USA, 8E2F3, 1:1000), anti-β-Actin (Invitrogen, MA5-15739 1:5000), anti-SOX2 (Abcam, Cambridge, UK, ab97959 1:1000), anti-Oct4 (Abcam, ab19857, 1:1000)...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11756514

In this study, we examined the recognition of various phenotypes of S. aureus by the CTLs MGL, langerin, MBL, and SP-D and explored the influence of CP and WTA on this interaction.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11746948

DESeq2 provide statistical routines for determining differential expression in digital gene expression data using a model based on the negative binomial distribution.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DESeq2", "pr...

PMC11687663

Proline and glycine residues are depicted as triangles, with 9 and 10 occurrences, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proline", "and", "glycine", "residues", "are", "depict...

PMC11615218

Regulatory T cells (TREG) play an essential role in maintaining immune homeostasis and self-tolerance.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Regulatory", "T", "cells", "(", "TREG", ")", "pl...

PMC11371747

Regarding modulation of 5FU, we used several CRC cell lines, previously characterized for their sensitivity to 5FU and the modulation by dl-LV (Van Triest et al., 1999).

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PMC10938377

Diffraction data were indexed, integrated, merged, scaled and evaluated with a combination of iMosflm, XDS, autoPROC, SCALA, and AIMLESS from the CCP4 package and in-house data processing pipelines, go.com and go.py, developed by the Swiss Light Source macromolecular crystallography beamlines (Paul Scherrer Institute, ...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11474209

Electrochemical immunosensors with conductive nanobiochar paperEnvironmental water0.017 μg/LCoating filter paper with highly conductive and dispersible nBC and anti-MCLR antibodies by dipping-drying created the paper immunosensor.ctDNA on gold electrodeLocal water bodies1.4 ng/LImmobilizing ctDNA on gold electrodes cre...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

To simulate the MM situation with an in vitro model, the magnetically GFPLucNCI-H929 was inoculated as MET into 6-well plate, cell islands were formulated under according tiny magnetisms, then MENK was added to observe its treatment effect.

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PMC9429973

Results: Median Hb concentration(g/dl) was at 4wks 9.5inA,8.6inB,8.8inC,at8wks 10.9inA,10.7inB,10inC,at 12wks 12.3inA,12.5inB,10.5inC. Median ferritin level(ng/ml) was at 0mo inA3,inB10,inC7;at3mo inA20,inB10,inC3;at6mo inA150,inB300,inC70.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11655536

Moreover, although studies are reporting the toxicity profiles and pharmacokinetics of HA with pre-clinical models [30–32], the safety and efficacy of HA need to be further explored in humans with phase I and II clinical trials, especially for the treatment of hematological diseases including MM.

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PMC11718274

The ROS-mediated mitochondrial pathway of apoptosis in Y2O3NPs treated A-431 cancer cells was further confirmed through the noticed significant increases in the expression of the apoptotic gene p53 in conjunction with significant decreases in the expression of the anti-apoptotic gene Bcl2 because overexpression of the ...

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PMC11720808

Data are represented as the mean ± SD (n=5). **

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PMC4355729

The PCR product was purified and cloned into pSin-GFP-vector to obtain Psin-GFP-PIK3R1.

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PMC11772449

White and Dipaola 2009; Shintani and Klionsky 2004).

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PMC11225860

depicts H&E stain from a vehicle control treated mouse.

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PMC11519077

The other proinflammatory cytokine upregulated by antigen-presenting cells in the intestinal tissue of CD patients is IL-12, which activates Type 1 helper T (Th1) cells to mediate the inflammatory response [84–86].

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PMC9429973

Day 60 mortality was 0%.

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PMC11615743

Afterward, all these strands were mixed together at a final concentration of 1 nM for each component in D‐PBS supplemented with 12.5 mM MgCl2 to form an AND logic device at 4 °C for 30 min.

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PMC11705067

However, FDX1 and DLAT genes are highly correlated with immune checkpoints, which result in favorable patient responses to immune checkpoint therapy.

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PMC10706275

After 48 h of culture, the cells were selected under 10 µg/mL puromycin pressure.

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PMC11617590

These data suggest that SFN inhibits cMyc through inhibition of GSK‐3β and NF‐κB p65.

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PMC9429973

We included all the cases of DLBCL diagnosed in University Hospital of Sfax between 2008-2019 that were refractory and/or relapsed.

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PMC11612626

HeLa cells (ATCC) were cultured in complete DMEM supplemented with 10% FBS.

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PMC11429241

With optimization of the fabrication process, 3D culture scaffolds can bring reproducibility to spheroid generation and ensure their adaptability for drug testing .

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PMC11621493

To compare transacylase and hydrolase activity, we determined time-dependent hydrolysis of the preferred phospholipid substrate PE in time-course experiments revealing a specific activity of 17.2 μmol/(mg∙h) (supplemental Fig. S2A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11172027

However, it is hardly known at what dose and for how long the treatment with selenium should last in order to ensure that there is an antioxidant protective effect, e.g., in glutathione peroxidase, on the one hand and to positively influence the development or cell growth of cancer via other non-apoptotic mechanisms on...

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PMC7841067

Our results suggest that AKAP4 is involved in the carcinogenesis and development of thyroid cancer and may serve as a potential therapeutic target for the treatment of thyroid cancer.

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PMC11252033

Briefly, for each cell line, an experimental triplicate was analyzed.

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PMC9429973

DHODH catalyzes the oxidation of DHO to orotic acid and is a rate-limiting enzyme in de novo pyrimidine nucleotide synthesis.

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PMC11741906

Additionally, we performed survival analysis to validate the potential clinical applicability of these miRNAs using data from ovarian cancer patients.

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PMC11486946

Single-molecule images of EGFR showed brighter and larger fluorescent spots were increased as the EGF concentration increased.

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PMC6442998

Slides were washed in TBS and incubated at RT for 1 hour in TBS containing the secondary antibodies.

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PMC11347429

For example, Bermejo-Martin et al. (19) observed impaired expression of several genes participating in the T cell and B cell immune responses in patients with severe influenza (patients requiring mechanical ventilation) compared to patients with reduced severity.

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PMC11538390

Data were presented as mean ± s.d.

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PMC11525028

Overexpression of ATF4, ASNS, or Asn supplementation significantly attenuated the impairment of tumor growth (Figure 5G) and resulted in shorter survival (Figure 5H).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10380508

Renal cell carcinoma (RCC) is the most common type of kidney malignancy, accounting for approximately 85% of kidney cancer cases.

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PMC11704135

H-NMR spectrum (CDCl3) of compound 13 illustrated (s, 6H, pyrimidine methyl protons) at 2.50, (s, 1H, aromatic protons of pyrimidine ring) at 7.54 and (m, 5H, aromatic protons) at 7.47–7.92 ppm.

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PMC8041314

Figure 3B summarizes the virtual screening processes of C@PA.

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PMC11525028

Xie et al. reported that NAT10 regulated the chemoresistance of bladder cancer through ac4C modification.

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PMC9341513

An emerging feature of the model is that clusters of proteins form at positions where there are bridges between DHSs, and that in most cases where a promoter is bound by a protein, it belongs to one of these clusters.

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PMC11621493

Lipids were analyzed by HPLC-MS 48 h posttransfection. (

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PMC11700165

Nuclear and cytoplasmic fractionation was done by using a fractionation reagent from Thermo Scientific.

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PMC10582049

For correlation analysis, we used Pearson correlation coefficient.

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PMC10729469

However, polyclonal Treg treatments rely on the bystander effect from Tregs homing into different tissues in an antigen-independent fashion resulting in global immune suppression .

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PMC9429973

Summary/Conclusion: The utility of mutational profiling may facilitate the identification of potential drug targets, which in turns may represent new therapeutic possibilities.

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PMC6442998

Clinicopathological features are given in Supplementary Tables 4 and 5.

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PMC11676169

After compiling and filtering the data (proteins representing a fold change (FC) ≥ 10 compared to control, p-value ≤ 0.05 in replicates), the protein list was queried on the Kyoto Encyclopedia of Genes and Genomes (KEGG) and hallmark gene sets using ShinyGO software to identify enriched pathways.

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PMC7812570

A Diagram of the lentiviral transfer vector expressing GPI-anchored antibodies.

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PMC11635519

The cells were then sent through a 40 μm filter to remove large clumps and loaded into either a FACScan Flow Cytometer (BD Bioscience) for cell analysis or a FACSVantage SE cell sorter (BD Bioscience) for cell sorting.

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PMC6182045

Here we report: (1) the screening and selection of a clade C gp120 (TZ97008) with improved ability to bind a panel of bNAbs, (2) the development of a stable, high expressing (>1g/L) MGAT1 CHO cell line that limits N-linked glycosylation for improved binding to glycan dependent bNAbs, (3) the development of an improved ...

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PMC10938336

These results revealed that both compounds 2 and 4 induced apoptosis in the promyelocytic leukemic cell line (HL-60) after 24 h treatment. (

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PMC11738017

The contribution of mBCMA to TCE activity is evident at a low E:T ratio (Figure 3H, left panel) when comparing GSI-treated OPM2 with OPM2_BCMA cells in which case, despite having similar sBCMA levels after GSI treatment, the higher mBCMA in OPM2_BCMA cells led to an improved TCE cytolytic effect.

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PMC11509224

The clerodane diterpene, named raspadiene (146, Figure 13), was isolated from the marine sponge Raspailia bouryesnaultae collected in South Brazil .

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PMC8303372

Based on the obtained results, all following experiments were carried out using the moderately toxic concentration (500 µmol/L GA) and a slightly toxic concentration (200 µmol/L GA) for both formulations.

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PMC11489351

A, glycolytic pathway genes with transcripts that were upregulated (magenta) or downregulated (cyan) at low pHi (EIPA, left) or high pHi (NH4Cl, right) compared to the control (MetaCore pathway analysis; see Methods).

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PMC8557138

As angiogenesis is a prerequisite for solid tumors to grow and metastasize, a variety of tumor angiogenesis models have been formulated to better understand the underlying mechanisms and associated clinical applications.

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PMC10944868

Where, the compound DTA0100 (Figure 1) clearly induced microtubule depolymerization, leading to disturbance of cell cycle kinetics and subsequent apoptosis (Podolski-Renić et al., 2017).

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PMC11779605

Our next validation step was to compare FGF7 protein levels in surgically collected tumor specimens with ascites specimens from patients with ovarian cancer.

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PMC11476666

Furthermore, preclinical studies in animal and clinical models have demonstrated that RSV, when combined with standard chemotherapy drugs, enhances therapeutic efficacy by sensitizing tumor cells to the effects of chemotherapeutics and overcoming multi-drug resistance, although some side effects, such as diarrhea, naus...

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PMC8875242

Both incubation steps were conducted in a humidified atmosphere of 80% O2 and 5% CO2 at 37 °C .

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PMC8633974

Cholesterol provided stability to the LNPs.

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PMC8041314

While 1,2,5-oxadiazoles have frequently been reported as (selective or dual) ABCB1 and ABCC1 inhibitors, 1,2,4-oxadiazoles have only once been reported as selective ABCG2 inhibitors or reversers of ABCB1-, ABCC1-, or ABCG2-mediated MDR.

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PMC11222184

SYBR green master mix (330500) and Human Cancer Pathway Finder™ PCR array (PAHS-033Z) was obtained from Qiagen.

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PMC11392912

The image shows the relative intensity of the DCFDA cellular ROS in RAFLS in different UT, VC, NC+TNF, and Clo-14+TNF groups. (

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PMC11705630

Various oncogenes such as mutant KRAS, PI3K, and MYC involved in the nucleotide synthesis pathways have been discovered 42-44.

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PMC11228511

NM ruptures occurred more frequently in progerin-expressing cells with an abnormal meshwork, suggesting that the irregularities and large openings in the meshwork weakened the nuclear lamina and were causally related to the emergence of NM ruptures and blebs.

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PMC11711347

The melting point, ranging from 226–228, suggests that the Ni(II)ProDtc complex is pure.

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PMC10196713

Similar results were obtained in A2780 cells, where upregulated mitochondrial membrane potential and lipid peroxidation by cisplatin could be suppressed by treatment with rotenone (Fig. S4A and B).

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PMC11552389

Time-lapse curve were generated with zencell-owl software (version 3.3, innoME GmbH), and analysed using their built-in algorithms of relative cell coverage, proportion of detached cells, and total cell numbers.

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PMC9429973

Summary/Conclusion: We have shown that EZH2i is not suitable in combination with the common chemotherapeutic Oxaliplatin in T-cell neoplasms.

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PMC9429973

In addition, we observed similar cancer-specific H3K4me3-BDs associated with super-enhancer hijacking of other common oncogenes in B-cell (MAF, MYC and FGFR3/NSD2) and T-cell malignancies (LMO2, TLX3 and TAL1).

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PMC10965680

Genetic structure of the 7 goat breeds. (

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PMC11676670

Cells were detached using 0.05% trypsin, washed three times with PBS, and fixed with 4% paraformaldehyde (Sigma-Aldrich, St. Louis, MO, USA).

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PMC10545062

To address this, we incorporated smaller and more modular fluid-based interventions.

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PMC6889484

These results confirmed that the A3x3G(DK) lentivector can efficiently transduce activated CD4 T cells and CD34 HSPCs.

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PMC9275501

Due to the hydrophobicity of CPT and the hydrophilicity of GEM, the prepared amphiphilic prodrug CPT-SS-GEM can self-assemble into organized nanoparticles to realize the self-delivery of CPT and GEM without additional materials.

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PMC11750712

However, physiological replacement, topical and inhaled steroids are permitted; cytotoxic chemotherapies within 2 weeks before leukapheresis or AUTO4 infusion; antibody therapy use within 2 weeks before AUTO4 infusion, or five half-lives of the respective antibody, whichever is longer; live vaccine within 4 weeks befor...

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PMC9429973

Here, we report further long-term safety, tolerability, and effectiveness of BCX9930.

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PMC11190538

The cells were grown at 37 °C in a humidified atmosphere of 5 % CO2.

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PMC11697189

However, due to the insensitivity of ccRCC to radiotherapy and chemotherapy, the mortality and recurrence rate of ccRCC are still very high.

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PMC11635087

For both whole cells and isolated chloroplasts, the chlorophyll fluorescence yield decreased regardless of whether they were treated with DCMU (Fig. 2A).

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PMC9429973

Mean delta liver iron content after esomeprazole treatment was -0.57mg Fe/g dw (SD 1.20; N=24) versus -0.11 (SD 0.75; N=23) after placebo treatment.

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PMC10123657

Cellular interactions within the bone marrow microenvironment modulate the properties of subsets of leukemic cells leading to the development of drug-resistant phenotypes.

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PMC10870498

Besides, overexpression of KIF23 promoted the viability and migration of 8505C and BCPAP cells, which was partly blocked by silenced SIRT7.

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PMC11495567

The transwell invasion assay was used to determine the PCAIs effects on cell invasion.

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PMC9000591

These compounds included calycosin , liquiritigenin , and ergosterol peroxide in SE4; pinoresinol in SE2; and maackiain and medicarpin in SE1 and SE2, respectively.

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PMC11489351

Scale bars represent 20 μm.

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PMC9429973

Interestingly, the taxonomic comparison revealed a significantly higher relative abundance of butyrate producer groups as Butyricicoccaceae (p=0.008), Clostridiaceae (p=0.009) and Oscillopiraceae (p=0.042) families in responders (Fig 1C).

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PMC11402217

Scale bars = 10 μM ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.

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PMC9599726

Before use, 1 μL of 30% H2O2 (Thermo Fisher Scientific, MA, United States, Cat# 241022500) was added to the DAB-Ni solution.

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PMC11682525

The hair follicles were then cut into several pieces and explanted onto collagen-coated cell culture plates, following previously described procedures ( 11 , 12 ).

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PMC8956657

Numbers next to nodes indicate bootstrap proportion support, and the scale indicates the number of nucleotide substitutions per site.

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PMC11655536

In other cases, LMP and cathepsin release are involved in the activation of effectors such as ROS, Bax, and iron, leading to other types of cell death, such as apoptosis, pyroptosis, and ferroptosis [25–27].

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PMC6642070

Insert is the average normalized to control in baseline. (

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PMC11092418

Protein samples (25 µg) were separated on 4-12% Bis-Tris gel (Invitrogen; Thermo Fisher Scientific, Inc.) using the Xcell II Surelock Mini-Cell system (Invitrogen; Thermo Fisher Scientific, Inc.) and transferred onto immobilon-polyvinylidene fluoride (FL PVDF) membranes (Merck), using Xcell II Mini-Cell Blot Module kit...

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PMC9587298

The electron charges for cyanidin, cyanidin-3-O-glucoside, cyanidin-3,5-O-diglucoside, cyanidin-3-O-sambubioside, cyanidin-3-O-sambubioside-5-O-glucoside in the flavylium cation form and carbinol pseudo-base form (hemiketal) and quercetin, quercetin-3-O-glucoside, quercetin-3-O-rutinoside, caffeic acid (dissociated) an...

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