OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11448304	19 genes/proteins were significantly regulated in all three omics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "19", "genes/proteins", "were", "significantly", "regulated", "in", "all", "three", "omics", "." ] } ]
PMC11733919	The activation of FOXO3a, a transcription factor modulating oxidative stress response and ROS-regulated processes, was observed upon 6 and 24 h treatment with MNP@CD26@17D (30 and 60 μg of Fe/mL) (Figure 5b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6771295	High expression of SIRT1 was linked to high risk osteosarcoma patients (55), however, SIRT1 expression has also been reported to be down-regulated in metastatic osteosarcoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11656380	Effects of Tat-Ram13 peptide on the cell viability of various cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Effects", "of", "Tat-Ram13", "peptide", "on", "the", "cell", "viability", "of", ...
PMC11754291	Fibroblasts were expanded from passages 2 to 6, mitotically inactivated through gamma irradiation (6,000 rad), and frozen at −80°C in serum containing 10% dimethyl sulfoxide (DMSO, Sigma-Aldrich, St-Louis, MO, United States) as described (Rochon et al., 2009).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7294030	The percentage of migration area after treatment with aurisin A (16.68 µM) at 24 and 48 h was 30.25 ± 6.79% and 7.30 ± 0.72%, respectively, compared with the control group 100 ± 0.0% (Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11781181	In vivo, IHC revealed significant NCOA4 upregulation and FTH1 downregulation in SJS/TEN skin lesions relative to those in patients with EM or MPE and healthy individuals (Fig. S8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11536589	Fig. 3Ferroptosis inhibition and upregulation of MGST1 expression conferred the KRAS inhibitor MRTX1133 resistance in PDAC cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "3Ferroptosis", "inhibition", "and", ...
PMC10047551	Cancer-based studies have described an inverse correlation between PD-L1 mRNA expression and methylation of cg19724470 in the CpG island south shore, situated 434 bp downstream of the PD-L1 transcriptional start site (Figure S1A) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11724582	The results revealed that the knockdown of YAP/TAZ corresponded to the phenotypic trends observed after intervention with CAFs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "revealed", "that", "...
PMC11342785	We next applied these assays to a series of TPPP truncations to quantitatively characterize the correlation between condensate formation and TPPP activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "next",...
PMC11283030	And targeting ACLY may serve as a novel therapeutic strategy for ccRCC treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "And", "targeting", "ACLY", "may", "serve", "as", "a", "novel", "thera...
PMC11297139	Scale bar: 5 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "5", "μm", "." ] } ]
PMC11673128	The completed characteristics of cell lines’ resistance to ALK inhibitors are depicted in Table S1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "completed", "characteristics", "of", "cell", "l...
PMC11188874	Proteasome activation represents a keystone event that is essential for effective immune activation with potential therapeutic benefit for many types of cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proteasome", ...
PMC10522430	The outcomes exhibited a reduction in cell viability with increasing doses of GACP extracts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "outcomes", "exhibited", "a", "reduction", "in", "cell", "...
PMC10940855	Of note, analysis of the Total Therapy dataset did not demonstrate an association between EPHB1 or EPHB4 expression and prognosis in multiple myeloma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Total PPPM healthcare cost was $19,895.8.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Total", "PPPM", "healthcare", "cost", "was", "$", "19,895.8", "." ] } ]
PMC8992508	In Figure 1, the secondary structures of the ABC family drug transporters P-gp, MRP1 and BCRP are depicted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "Figure", "1", ",...
PMC11536589	Data represent means ± SEM from three independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "represent", "means", "±", "SEM", "from", "three", "independent", "experiments", "." ] } ]
PMC11518702	Left panel: as a comparator, core components of the BCR are diagrammed, including the LYN, BCR alpha, beta chain, and SYK-mediated recruitment of HGAL, together with GRB2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9878562	The same analysis performed for the velocity of VAL-wt revealed that the motility of the cells was also influenced by the presence of a motile VAL-wt within a radius of 50 µm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11013014	C NMR (101 MHz, CDCl3); δ (ppm): 195.4, 164.5, 154.3, 150.1, 144.5, 143.9, 134.5, 132.2, 131.7, 131.6, 128.8, 127.3, 123.1, 116.8, 112.1, 111.2, 109.5, 68.4, 31.1, 23.4, 12.4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11218145	Ten days after cell inoculation tumour take-rate in the peritoneal cavity was evaluated by two Bioluminescent imaging (BLI) acquired two days apart.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11422150	Second, we focused on MDSCs, which were initially characterized in cancer patients and linked to enhanced tumor progression and impaired T-cell function (Bronte et al., 2000).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9844987	Here, we provide a comprehensive characterization of the sequences, TSS architectures, and regulatory processes determining variability of promoter activity across human lymphoblastoid cell lines (LCLs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11779605	Patient demographics were compared using the Fisher’s exact test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patient", "demographics", "were", "compared", "using", "the", "Fisher", "’s", "exact", "test", ...
PMC11718109	Synapses can be broadly categorized into classical or neuromodulatory depending on the type of neurotransmitters released.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Synapses", "can", "be", "broadly", "categorized", "int...
PMC9325715	When a small amount of Fe is bound to ferritin they are coordinated to oxygen-containing groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "a", "small", "amount", "of", "Fe", "is",...
PMC11806182	MiR-1246 was identified as a signature that could discriminate high-grade serous ovarian cancer patients with high accuracy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MiR-1246", "was", "identified", "as", "a", ...
PMC9429973	Six (35%) patients were hospitalized, among which four (24%) needed supplementary oxygen and two (12%) intensive care.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5941560	Homozygous deletions were also merged in a special manner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Homozygous", "deletions", "were", "also", "merged", "in", "a", "special", "manner", "." ] } ]
PMC11301095	In this instance, the pediatric patient was diagnosed via CSF mNGS within 24 h of hospital admission.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "instance", ",", "the", ...
PMC11615101	Secretion of pro-inflammatory cytokines such as Interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNF-α), and Interleukin-1β (IL-1β) by activation of signaling pathways3 majorly Nuclear Factor kappa B (NF-κB) and a mitogen-activated protein kinase (MAPK)4 in the osteoclasts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5417661	Cord formation/disruption was monitored kinetically using IncuCyte live cell imaging system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cord", "formation/disruption", "was", "monitored", "kinetically", "using", "IncuCyte", "live", ...
PMC11306331	The top twenty genes among genes whose expression level increased or decreased after doxycycline induction of FUS-CHOP are shown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "top", "twenty", "genes", ...
PMC10204952	Data of the nucleic alteration (DAPI staining) were calculated from three independent experiments with each experiment containing three replicates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "of", "the...
PMC10291556	The unconventional Pt(IV) complexes 2–4 tested in this work, as well as the parental Pt(II) complex 1, contain a 1,2-diaminocyclohexane ring (although in a 1S,2S configuration).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770746	Schematic illustration of the reduction of multitargeting prodrug cisPt(Pac)(OH) to release the original, unmodified paclitaxel and HPLC chromatograms of cisPt(Pac)(OH), commercial paclitaxel, and a chromatogram of the reaction mixture following 10 min of incubation with 10 equiv of ascorbate (lower chromatogram) confi...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11463018	C21H19N5O2, [M + H] m/z: 374.16115, found: 374.16116.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C21H19N5O2", ",", "[", "M", "+", "H", "]", "m/z", ":", ...
PMC8524093	Infected neonates usually develop pain, prostration, fever, and thrombocytopenia within few days after birth, and some of them may even have encephalopathy and intracranial bleeding with persistent sequelae (Gérardin et al., 2008; Ramful et al., 2014).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721096	In this work, the CHO cells stably transfected with human tyrosinase addressed this issue by providing a sufficient quantity of the enzyme with good stability and reusability, ensuring a more viable result for the screening of inhibitors of the enzyme.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10174970	We could choose a more optimal PAAD cell line based on the genetic similarity between them.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "could", "choose", "a", "more", "optimal", ...
PMC9684669	cDNA libraries were generated using Illumina TruSeq Stranded mRNA sample preparation kit (Illumina # RS-122-2103).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "cDNA", "libraries", "were", "gene...
PMC9429973	Adapting autologous chimeric antigen receptor (CAR) T cell therapy for TCL continues to be challenging due to poor function of donor T cells, fratricide effect, and risk of infusing transduced malignant CAR T cells into pts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11406030	The study was conducted according to the Declaration of Helsinki and was approved by the Regional Ethics Committee (approval no. 767-14).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11632064	Impact of CRISPR-Cas9-mediated loss of genes encoding for RSK family members and putative targets of BI-D1870 on proliferation dynamics (Chronos algorithm) of human melanoma cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11548041	A protein preparation wizard was used to resolve the 3D structures, and protein–nucleotide docking between the EpEX monomer and each folded aptamer was performed using the standard mode, 70,000 rotations, and 30 poses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8753818	As fundamental research, finding of this study clears the dominant role of caspase-3 in progression of apoptosis in the lack of caspase-7 in CHO cells; which approved the previous data in this case.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC11297139	Additionally, ARID1A contains a structured Pfam homology domain that directly binds to components of the BAF complex.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "ARID1A", "contains", ...
PMC11098378	We found that human Flag-SHOC2 and Flag-PSMC1 proteins were dramatically reduced in abundance when co-transfected with GFP-IpaH4 in LD652 cells, suggesting that IpaH4 can target these human proteins when expressed in either human or moth cells (Fig 5H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", ...
PMC9841531	Constrained to the reference ABCB1 inhibitor 34.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Constrained", "to", "the", "reference", "ABCB1", "inhibitor", "34", "." ] } ]
PMC11701801	The cells were then transfected with the siRNAs for an additional 24 hours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "then", "transfected", "with", "the", "siRNAs", ...
PMC11755624	The activity of NORAD was also tested in psoriasis in in vitro and in vivo experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "activity", "of", "NORAD", "was", "also", ...
PMC6617630	Raji MYC 1R1G1F, BCL-2 3F, and BCL-6 2F (m-o) Identification of MYC, BCL-2, and BCL-6 rearrangements in human DLBCL and BL cell lines: c-MYC, BCL-2, and BCL-6 rearrangements were analyzed with break-apart FISH in human DLBCL (n = 9) and Burkitt Lymphoma cell lines (n = 2) MYC overexpression has been shown to be regulat...	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787355	in 100 µl PBS.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "in", "100", "µl", "PBS", "." ] } ]
PMC9596868	No. 56916) at 595 nm using Lambda 25 UV/Vis spectrophotometer with UV WINLAB software (Version 2.85.04) (PerkinElmer, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Palliative care was received by 23 patients (38%), these were predominantly elderly patients with a median age of 71 years (range 45-91 years), with severe COVID-19.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11731161	Targeting exportin1 (XPO1) with Selinexor (SEL) is a promising therapeutic strategy for patients with multiple myeloma (MM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Targeti...
PMC7802142	It is also thought to be a reservoir of multipotent stem cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "also", "thought", "to", "be", "a", "reservoir", "of", "multipo...
PMC11539788	Similarly, in the transwell invasion assay, the invasion capacity of BCa cells in the LV-RNF19A group was impaired (Fig. 2H-I).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10798140	MET protein is a receptor protein-tyrosine kinase for hepatocyte growth factor produced by stromal and mesenchymal cells that regulates cell growth, morphogenesis, and motility.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC7452526	Figure 1 shows the UV–Visible absorption spectrum of the synthesized AgNPs at different incubation time (10, 30, and 120 min).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11525293	4Thal impairs in vitro infection by GFP-expressing pseudo-SARS-CoV-2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "4Thal", "impairs", "in", "vitro", "infection", "by", "GFP-expressing", "pseudo-SARS-CoV-2", "." ] } ]
PMC7887261	Briefly, the damage ratio is defined as (Q2/Q3)/(Q1/Q4), where Q2 is the portion of transfected γH2AX-positive cells; Q3 is the portion of transfected, γH2AX -negative cells; Q1 is the portion of untransfected, γH2AX-positive cells; and Q4 is the portion of untransfected, γH2AX-negative cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11683240	A, schematic representation of experimental setup for the enzyme activity assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ",", "schematic", "representation", "of", "experimental", "setup", "for", "t...
PMC7757104	Thus, OPNc may act directly and indirectly by promoting the activation of signaling pathways associated with cell survival, inhibition of apoptosis, tumor progression and chemoresistance in ovarian cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11224020	g, Left, projection of cell nuclei; scale bar, 10 µm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "g", ",", "Left", ",", "projection", "of", "cell", "nuclei", ...
PMC9429973	There was 1 event of colitis (Grade 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "was", "1", "event", "of", "colitis", "(", "Grade", "1", ")", "." ] } ]
PMC7154001	No other search conditions were applied.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "other", "search", "conditions", "were", "applied", "." ] } ]
PMC9000591	Recent trends in developing various alternative medicines also have led to a proliferation of studies in exploiting benefits from plants.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "trends", "in", ...
PMC11547972	However, some patients suffered from digestive problems, nausea, and emesis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "some", "patients", "suffered", "from", "digestive", "proble...
PMC10812665	We directly compared MPP- and Ber-induced metabolic responses on a metabolite-by-metabolite level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "directly", "compared", "MPP-", "and", "Ber-induced", "metabolic", "responses", ...
PMC9429973	Treatment-related mortality was 12,5% and meantime to relapse was 6,2 months in 5 patients (45%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment-related", "mortality", "was",...
PMC11694066	B, Waterfall plot displaying the difference in AUC between the JN1 cell line (AUCJN1) and the panel of 92 cell lines used for comparison (AUCmedian) for the 79 evaluated small-molecule inhibitors or drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11470381	Seed the transfected cells at a density of 1 × 10 cells per well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Seed", "the", "transfected", "cells", "at", "a", "density", "of"...
PMC11733919	a, b) Three time points (2, 6, and/or 24 h) and two markers of apoptosis were considered, namely, caspase 3 levels (imaging flow cytometry using a dedicated anticaspase 3 antibody, Ch02, green signals) and phosphatidylserine externalization (flow cytometry and Annexin V staining). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11676169	The efficacy of DNA double-strand repair was determined using GFP-based reporter assays as described previously .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "efficacy", "of", "DNA", "double-strand", "repair", "...
PMC10203589	Surgery, radiotherapy, and chemotherapy are still the most basic options for breast cancer treatment (108, 109).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Surgery", ",", "r...
PMC11473750	5% of the cell lysate was loaded for input.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "5", "%", "of", "the", "cell", "lysate", "was", "loaded", "for", "input", "." ] } ]
PMC3681794	Total RNA was isolated using the Qiagen RNeasy Kit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Total", "RNA", "was", "isolated", "using", "the", "Qiagen", "RNeasy", "Kit", "." ] } ]
PMC11718031	Different performance parameters of bioproduction impacted by these media were plotted as outlined in Supplementary Fig. S1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Different", "performance", "parameters", "of", "b...
PMC11127909	Right: The maximum respiration of 143B-V and 143B-EFHD1 cells was recorded after FCCP uncoupling, N = 3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Right", ":", "The", ...
PMC10170482	Here, we report that the soft 3D microenvironment upregulates the glycolysis of HepG2 and Alexander cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "Here", ",", "we", "report", "th...
PMC2614415	Aurora-A kinase and TPX2, an activator of Aurora-A, are two of the most significantly overexpressed genes in ovarian carcinomas.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aurora-A", "kinase", ...
PMC8009078	The European countries, M. alba is welcomed as a ‘superfood’ due to the presence of the high amount of bioactive constituents which are beneficial to promote health and longevity .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10587429	The percentage of T, B, NK and monocytes were around 20-30% in the blood and 15-40% in the spleen and bone marrow ( Figure 2F ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Frequency and severity of TEAEs did not increase with escalating doses and all TEAEs were reversible.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Frequency", "and", "severity", "of", "TEAEs", "did", ...
PMC9429973	Nevertheless, TKIs are minimally effective CML patients progressed to blast crisis (BC-CML).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nevertheless", ",", "TKIs", "are", "minimally", "effective", ...
PMC11672142	Trp, in particular, forms a redox active ferrous complex that inactivates the Fe-dependent ribonucleotide reductase (RNR), responsible for DNA replication.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC3888431	The resulting gene loci in GFF file format were clustered using the gffread tool from the Cufflinks distribution with the “–cluster-only” parameter.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11791432	The data showed that compared with the NC group, knockdown of ANXA1 had a protective effect on the survival prognosis of mice (HR=0.212, P = 0.035), further supporting the unfavorable prognostic role of ANXA1 in gliomas.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11731614	These fractions lacked Gm130 and Calnexin, which are Golgi-associated proteins (Théry, 2018) (Fig. 1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "fractions", "lacked...
PMC11173119	Consequently, starting from the 14th day of differentiation and proceeded for over 3 weeks, monocytes were generated in the culture medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequ...
PMC9429973	The PROs analyses included pts from the interim analysis (median follow-up: 14.0 months) who had at least a baseline and a follow-up questionnaire available.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Except 1 female died from severe pulmonary infection, other 10 patients were followed up for more than 1 month.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Except", "1", "female", ...
PMC11794568	Relative mtDNA copy number was measured using an RT-qPCR-based method as described previously.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relative", "mtDNA", "copy", "number", "was", "measured", "using", "an", ...
PMC10048572	Su et al. studied transcriptome landscape of childhood acute megakaryoblastic leukemia (AMKL), an extremely unfavorable variant of AML, using the scRNA-seq (single-cell RNA sequencing) technique.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11747467	Furthermore, due to the low toxicity and good tolerability of ART, regular treatment with ART could be considered for bladder cancer patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11342785	All the quantification analyses of the fluorescence images were performed using Fiji.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "the", "quantification", "analyses", "of", "the", "fluorescence", "images", ...

PMC11448304

19 genes/proteins were significantly regulated in all three omics.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "19", "genes/proteins", "were", "significantly", "regulated", "in", "all", "three", "omics", "." ] } ]

PMC11733919

The activation of FOXO3a, a transcription factor modulating oxidative stress response and ROS-regulated processes, was observed upon 6 and 24 h treatment with MNP@CD26@17D (30 and 60 μg of Fe/mL) (Figure 5b).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6771295

High expression of SIRT1 was linked to high risk osteosarcoma patients (55), however, SIRT1 expression has also been reported to be down-regulated in metastatic osteosarcoma.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11656380

Effects of Tat-Ram13 peptide on the cell viability of various cells. (

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PMC11754291

Fibroblasts were expanded from passages 2 to 6, mitotically inactivated through gamma irradiation (6,000 rad), and frozen at −80°C in serum containing 10% dimethyl sulfoxide (DMSO, Sigma-Aldrich, St-Louis, MO, United States) as described (Rochon et al., 2009).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7294030

The percentage of migration area after treatment with aurisin A (16.68 µM) at 24 and 48 h was 30.25 ± 6.79% and 7.30 ± 0.72%, respectively, compared with the control group 100 ± 0.0% (Figure 2).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11781181

In vivo, IHC revealed significant NCOA4 upregulation and FTH1 downregulation in SJS/TEN skin lesions relative to those in patients with EM or MPE and healthy individuals (Fig. S8).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11536589

Fig. 3Ferroptosis inhibition and upregulation of MGST1 expression conferred the KRAS inhibitor MRTX1133 resistance in PDAC cells. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "3Ferroptosis", "inhibition", "and", ...

PMC10047551

Cancer-based studies have described an inverse correlation between PD-L1 mRNA expression and methylation of cg19724470 in the CpG island south shore, situated 434 bp downstream of the PD-L1 transcriptional start site (Figure S1A) .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11724582

The results revealed that the knockdown of YAP/TAZ corresponded to the phenotypic trends observed after intervention with CAFs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "revealed", "that", "...

PMC11342785

We next applied these assays to a series of TPPP truncations to quantitatively characterize the correlation between condensate formation and TPPP activity.

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PMC11283030

And targeting ACLY may serve as a novel therapeutic strategy for ccRCC treatment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "And", "targeting", "ACLY", "may", "serve", "as", "a", "novel", "thera...

PMC11297139

Scale bar: 5 μm.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "5", "μm", "." ] } ]

PMC11673128

The completed characteristics of cell lines’ resistance to ALK inhibitors are depicted in Table S1.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "completed", "characteristics", "of", "cell", "l...

PMC11188874

Proteasome activation represents a keystone event that is essential for effective immune activation with potential therapeutic benefit for many types of cancer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proteasome", ...

PMC10522430

The outcomes exhibited a reduction in cell viability with increasing doses of GACP extracts.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "outcomes", "exhibited", "a", "reduction", "in", "cell", "...

PMC10940855

Of note, analysis of the Total Therapy dataset did not demonstrate an association between EPHB1 or EPHB4 expression and prognosis in multiple myeloma.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC9429973

Total PPPM healthcare cost was $19,895.8.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Total", "PPPM", "healthcare", "cost", "was", "$", "19,895.8", "." ] } ]

PMC8992508

In Figure 1, the secondary structures of the ABC family drug transporters P-gp, MRP1 and BCRP are depicted.

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PMC11536589

Data represent means ± SEM from three independent experiments.

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PMC11518702

Left panel: as a comparator, core components of the BCR are diagrammed, including the LYN, BCR alpha, beta chain, and SYK-mediated recruitment of HGAL, together with GRB2.

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PMC9878562

The same analysis performed for the velocity of VAL-wt revealed that the motility of the cells was also influenced by the presence of a motile VAL-wt within a radius of 50 µm.

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PMC11013014

C NMR (101 MHz, CDCl3); δ (ppm): 195.4, 164.5, 154.3, 150.1, 144.5, 143.9, 134.5, 132.2, 131.7, 131.6, 128.8, 127.3, 123.1, 116.8, 112.1, 111.2, 109.5, 68.4, 31.1, 23.4, 12.4.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11218145

Ten days after cell inoculation tumour take-rate in the peritoneal cavity was evaluated by two Bioluminescent imaging (BLI) acquired two days apart.

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PMC11422150

Second, we focused on MDSCs, which were initially characterized in cancer patients and linked to enhanced tumor progression and impaired T-cell function (Bronte et al., 2000).

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PMC9844987

Here, we provide a comprehensive characterization of the sequences, TSS architectures, and regulatory processes determining variability of promoter activity across human lymphoblastoid cell lines (LCLs).

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PMC11779605

Patient demographics were compared using the Fisher’s exact test.

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PMC11718109

Synapses can be broadly categorized into classical or neuromodulatory depending on the type of neurotransmitters released.

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PMC9325715

When a small amount of Fe is bound to ferritin they are coordinated to oxygen-containing groups.

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PMC11806182

MiR-1246 was identified as a signature that could discriminate high-grade serous ovarian cancer patients with high accuracy .

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PMC9429973

Six (35%) patients were hospitalized, among which four (24%) needed supplementary oxygen and two (12%) intensive care.

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PMC5941560

Homozygous deletions were also merged in a special manner.

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PMC11301095

In this instance, the pediatric patient was diagnosed via CSF mNGS within 24 h of hospital admission.

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PMC11615101

Secretion of pro-inflammatory cytokines such as Interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNF-α), and Interleukin-1β (IL-1β) by activation of signaling pathways3 majorly Nuclear Factor kappa B (NF-κB) and a mitogen-activated protein kinase (MAPK)4 in the osteoclasts.

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PMC5417661

Cord formation/disruption was monitored kinetically using IncuCyte live cell imaging system.

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PMC11306331

The top twenty genes among genes whose expression level increased or decreased after doxycycline induction of FUS-CHOP are shown.

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PMC10204952

Data of the nucleic alteration (DAPI staining) were calculated from three independent experiments with each experiment containing three replicates.

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PMC10291556

The unconventional Pt(IV) complexes 2–4 tested in this work, as well as the parental Pt(II) complex 1, contain a 1,2-diaminocyclohexane ring (although in a 1S,2S configuration).

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PMC11770746

Schematic illustration of the reduction of multitargeting prodrug cisPt(Pac)(OH) to release the original, unmodified paclitaxel and HPLC chromatograms of cisPt(Pac)(OH), commercial paclitaxel, and a chromatogram of the reaction mixture following 10 min of incubation with 10 equiv of ascorbate (lower chromatogram) confi...

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PMC11463018

C21H19N5O2, [M + H] m/z: 374.16115, found: 374.16116.

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PMC8524093

Infected neonates usually develop pain, prostration, fever, and thrombocytopenia within few days after birth, and some of them may even have encephalopathy and intracranial bleeding with persistent sequelae (Gérardin et al., 2008; Ramful et al., 2014).

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PMC11721096

In this work, the CHO cells stably transfected with human tyrosinase addressed this issue by providing a sufficient quantity of the enzyme with good stability and reusability, ensuring a more viable result for the screening of inhibitors of the enzyme.

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PMC10174970

We could choose a more optimal PAAD cell line based on the genetic similarity between them.

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PMC9684669

cDNA libraries were generated using Illumina TruSeq Stranded mRNA sample preparation kit (Illumina # RS-122-2103).

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PMC9429973

Adapting autologous chimeric antigen receptor (CAR) T cell therapy for TCL continues to be challenging due to poor function of donor T cells, fratricide effect, and risk of infusing transduced malignant CAR T cells into pts.

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PMC11406030

The study was conducted according to the Declaration of Helsinki and was approved by the Regional Ethics Committee (approval no. 767-14).

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PMC11632064

Impact of CRISPR-Cas9-mediated loss of genes encoding for RSK family members and putative targets of BI-D1870 on proliferation dynamics (Chronos algorithm) of human melanoma cell lines.

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PMC11548041

A protein preparation wizard was used to resolve the 3D structures, and protein–nucleotide docking between the EpEX monomer and each folded aptamer was performed using the standard mode, 70,000 rotations, and 30 poses.

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PMC8753818

As fundamental research, finding of this study clears the dominant role of caspase-3 in progression of apoptosis in the lack of caspase-7 in CHO cells; which approved the previous data in this case.

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PMC11297139

Additionally, ARID1A contains a structured Pfam homology domain that directly binds to components of the BAF complex.

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PMC11098378

We found that human Flag-SHOC2 and Flag-PSMC1 proteins were dramatically reduced in abundance when co-transfected with GFP-IpaH4 in LD652 cells, suggesting that IpaH4 can target these human proteins when expressed in either human or moth cells (Fig 5H).

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PMC9841531

Constrained to the reference ABCB1 inhibitor 34.

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PMC11701801

The cells were then transfected with the siRNAs for an additional 24 hours.

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PMC11755624

The activity of NORAD was also tested in psoriasis in in vitro and in vivo experiments.

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PMC6617630

Raji MYC 1R1G1F, BCL-2 3F, and BCL-6 2F (m-o) Identification of MYC, BCL-2, and BCL-6 rearrangements in human DLBCL and BL cell lines: c-MYC, BCL-2, and BCL-6 rearrangements were analyzed with break-apart FISH in human DLBCL (n = 9) and Burkitt Lymphoma cell lines (n = 2) MYC overexpression has been shown to be regulat...

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PMC11787355

in 100 µl PBS.

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PMC9596868

No. 56916) at 595 nm using Lambda 25 UV/Vis spectrophotometer with UV WINLAB software (Version 2.85.04) (PerkinElmer, USA).

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PMC9429973

Palliative care was received by 23 patients (38%), these were predominantly elderly patients with a median age of 71 years (range 45-91 years), with severe COVID-19.

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PMC11731161

Targeting exportin1 (XPO1) with Selinexor (SEL) is a promising therapeutic strategy for patients with multiple myeloma (MM).

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PMC7802142

It is also thought to be a reservoir of multipotent stem cells .

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PMC11539788

Similarly, in the transwell invasion assay, the invasion capacity of BCa cells in the LV-RNF19A group was impaired (Fig. 2H-I).

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PMC10798140

MET protein is a receptor protein-tyrosine kinase for hepatocyte growth factor produced by stromal and mesenchymal cells that regulates cell growth, morphogenesis, and motility.

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PMC7452526

Figure 1 shows the UV–Visible absorption spectrum of the synthesized AgNPs at different incubation time (10, 30, and 120 min).

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PMC11525293

4Thal impairs in vitro infection by GFP-expressing pseudo-SARS-CoV-2.

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PMC7887261

Briefly, the damage ratio is defined as (Q2/Q3)/(Q1/Q4), where Q2 is the portion of transfected γH2AX-positive cells; Q3 is the portion of transfected, γH2AX -negative cells; Q1 is the portion of untransfected, γH2AX-positive cells; and Q4 is the portion of untransfected, γH2AX-negative cells.

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PMC11683240

A, schematic representation of experimental setup for the enzyme activity assay.

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PMC7757104

Thus, OPNc may act directly and indirectly by promoting the activation of signaling pathways associated with cell survival, inhibition of apoptosis, tumor progression and chemoresistance in ovarian cancer.

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PMC11224020

g, Left, projection of cell nuclei; scale bar, 10 µm.

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PMC9429973

There was 1 event of colitis (Grade 1).

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PMC7154001

No other search conditions were applied.

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PMC9000591

Recent trends in developing various alternative medicines also have led to a proliferation of studies in exploiting benefits from plants.

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PMC11547972

However, some patients suffered from digestive problems, nausea, and emesis .

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PMC10812665

We directly compared MPP- and Ber-induced metabolic responses on a metabolite-by-metabolite level.

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PMC9429973

Treatment-related mortality was 12,5% and meantime to relapse was 6,2 months in 5 patients (45%).

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PMC11694066

B, Waterfall plot displaying the difference in AUC between the JN1 cell line (AUCJN1) and the panel of 92 cell lines used for comparison (AUCmedian) for the 79 evaluated small-molecule inhibitors or drugs.

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PMC11470381

Seed the transfected cells at a density of 1 × 10 cells per well.

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PMC11733919

a, b) Three time points (2, 6, and/or 24 h) and two markers of apoptosis were considered, namely, caspase 3 levels (imaging flow cytometry using a dedicated anticaspase 3 antibody, Ch02, green signals) and phosphatidylserine externalization (flow cytometry and Annexin V staining). (

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PMC11676169

The efficacy of DNA double-strand repair was determined using GFP-based reporter assays as described previously .

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PMC10203589

Surgery, radiotherapy, and chemotherapy are still the most basic options for breast cancer treatment (108, 109).

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PMC11473750

5% of the cell lysate was loaded for input.

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PMC3681794

Total RNA was isolated using the Qiagen RNeasy Kit.

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PMC11718031

Different performance parameters of bioproduction impacted by these media were plotted as outlined in Supplementary Fig. S1.

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PMC11127909

Right: The maximum respiration of 143B-V and 143B-EFHD1 cells was recorded after FCCP uncoupling, N = 3.

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PMC10170482

Here, we report that the soft 3D microenvironment upregulates the glycolysis of HepG2 and Alexander cells.

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PMC2614415

Aurora-A kinase and TPX2, an activator of Aurora-A, are two of the most significantly overexpressed genes in ovarian carcinomas.

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PMC8009078

The European countries, M. alba is welcomed as a ‘superfood’ due to the presence of the high amount of bioactive constituents which are beneficial to promote health and longevity .

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PMC10587429

The percentage of T, B, NK and monocytes were around 20-30% in the blood and 15-40% in the spleen and bone marrow ( Figure 2F ).

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PMC9429973

Frequency and severity of TEAEs did not increase with escalating doses and all TEAEs were reversible.

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PMC9429973

Nevertheless, TKIs are minimally effective CML patients progressed to blast crisis (BC-CML).

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PMC11672142

Trp, in particular, forms a redox active ferrous complex that inactivates the Fe-dependent ribonucleotide reductase (RNR), responsible for DNA replication.

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PMC3888431

The resulting gene loci in GFF file format were clustered using the gffread tool from the Cufflinks distribution with the “–cluster-only” parameter.

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PMC11791432

The data showed that compared with the NC group, knockdown of ANXA1 had a protective effect on the survival prognosis of mice (HR=0.212, P = 0.035), further supporting the unfavorable prognostic role of ANXA1 in gliomas.

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PMC11731614

These fractions lacked Gm130 and Calnexin, which are Golgi-associated proteins (Théry, 2018) (Fig. 1B).

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PMC11173119

Consequently, starting from the 14th day of differentiation and proceeded for over 3 weeks, monocytes were generated in the culture medium.

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PMC9429973

The PROs analyses included pts from the interim analysis (median follow-up: 14.0 months) who had at least a baseline and a follow-up questionnaire available.

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PMC9429973

Except 1 female died from severe pulmonary infection, other 10 patients were followed up for more than 1 month.

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PMC11794568

Relative mtDNA copy number was measured using an RT-qPCR-based method as described previously.

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PMC10048572

Su et al. studied transcriptome landscape of childhood acute megakaryoblastic leukemia (AMKL), an extremely unfavorable variant of AML, using the scRNA-seq (single-cell RNA sequencing) technique.

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PMC11747467

Furthermore, due to the low toxicity and good tolerability of ART, regular treatment with ART could be considered for bladder cancer patients.

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PMC11342785

All the quantification analyses of the fluorescence images were performed using Fiji.

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