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PMC5673955
Continuous RrA exposure of these cells resulted in shortening of telomeres followed by cell cycle inhibition, replicative senescence, and development of apoptosis.
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PMC11461833
KAT7 is considered as a positive regulator of cellular senescence, and knockdown of KAT7 is a strategy for delaying cellular senescence and extending the life span in vivo.
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PMC11684821
For TCR KI, only 21% and 26% of CD8 T cells expressing the rat CD2 transduction marker stained with TRBV25 antibody, which is a similar level of transduction to that observed by Dukes and colleagues using a partially murinized TCR construct (29).
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PMC6650823
Highlighted by M. Helena Vasconcelos Reactivation of the phosphatase and tensin homologue deleted on chromosome 10 (PTEN), a tumor suppressor which is often inactivated in various human cancers, could be an effective approach for cancer treatment .
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PMC9143157
Further investigations are warranted to clarify this issue.
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PMC11129910
Bacterial colonies were subjected to ampicillin selection at 100 μg/ml (Thermo Fisher Scientific, MA, USA).
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PMC11772449
n= 3, *P<0.05). **
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PMC9268620
As a consequence, cytosolic Ca increases .
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PMC6487404
As demonstrated in Table 2, adding verapamil (100 µM) or valspodar (5 µM) to the medium of Caco-2 cell monolayers did not affect drug transport or efflux ratio.
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PMC9429973
Fig.1: (A) Patient disposition and survival, (B) OS and RFS for the entire cohort, (C) OS of responders and non-responders The therapy was generally well-tolerated.
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PMC11574271
The results showed that the positive expression rate of RON in bladder cancer tissues was 90.3%, while that in normal tissues was only 23.1% (Fig. 1A, B).
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PMC11575040
After incubation at 37 °C for 2 weeks, cancer cell colonies were fixed with 3.7% formaldehyde for 10 min and stained with 0.2% crystal violet in 10% ethanol for 3 h. After the wells were rinsed with H2O, they were air-dried.
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PMC8494202
As shown in Figures 2(a)–2(c), increased expression of CKAP2L in the three datasets was associated with decreased patient overall survival (P < 0.001).
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PMC11770746
The structures of CisPt(OAc)2, oxaliPt(OAc)2, cisPt(Pac)(OH), and paclitaxel as well as the synthesis of cisPt(Pac)(OH) are depicted in Figure 2.
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PMC11507371
The differential response between HaCaT and A431 cells underscores the varied antioxidative capacities, contributing to their distinct molecular responses to CAP-induced oxidative stress.
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PMC10976516
These promising developments coincide with the remarkable breakthrough of immunotherapy using ICIs in the treatment of lung cancer.
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PMC9848491
PHE exposure induced mitochondrial dysfunction and ER stress, which results in the cytoplasm reactive oxygen species and abnormal calcium levels, final oocyte induced oxidative stress and DNA damage (29).
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PMC11413393
A total of 250 mg of Biotin (BioBasic ref# BB0078) was dissolved in 2.04 ml of NH4OH 28-30% (SIGMA ref# 221228) to produce a 500 mM solution.
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PMC11740207
Like LT-HSCs, MIAMICs rely on glycolytic metabolism, enabling them to function efficiently in oxygen-poor environments.
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PMC11697703
Thus, regulation of MAPK8 signaling via expression of miR-193b∼365 cluster contributes to the development of dendritic arbors appropriate for corticospinal projection neurons, providing a mechanism that coordinates projection neuron identity, specified by Fezf2, and neuron-specific dendritic morphology.
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PMC11461025
For example, phosphorylated and therefore activated ERK has been shown to lead to cell cycle arrest and apoptosis in fibroblast (NIH3T3), breast cancer (MCF-7), and human keratinocytes (HaCaT) cells treated with etoposide (Tang et al. 2002; Lee et al. 2005) , while cisplatin treatment resulted in ERK activation which w...
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PMC10212663
RANKL is strongly expressed in advanced KRAS‐mt LUAD, and significantly distinct association exists between high RANKL expression and poor survival.
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PMC11172027
Even 250 µg/mL NASeLM already indicated a maximum value of caspase-3 activity during apoptosis, which could no longer be surpassed when the concentration was increased up to 500 µg/mL. NALM was also able to reduce mitochondrial activity and cell growth, but to a much lesser extent than NASeLM.
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PMC11597291
At pH 6.0 (Figure 4B), a higher PCT release was observed for all particles compared to the release at pH 7.4.
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PMC7053076
All data are presented as mean ± SEM.
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PMC10761571
Finally, qPCR assay was performed using the primers presented in Table 1 to find out the expression level of the CASP8, BAX, and BCL2 genes under treatment of Fe3O4@Glu-Gingerol and Fe3O4 NPs.
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PMC11495567
To further our understanding of the effects of PCAIs on the NCI-H23 lung cancer cells, we probed for proteins further downstream of KRAS by western blotting (Fig 4).
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PMC2944824
No change in p53 mRNA was observed as measured by RT-PCR and real time PCR (data not shown).
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PMC11738017
In addition to predicting the overall response, high baseline sBCMA levels above 400 ng/mL (cutoff selected based on our preclinical observation of the inhibitory effect of sBCMA, as depicted in Figure 2E) correlated with a significantly shorter PFS (Figure 5E).
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PMC11626627
Pengfei Zhou: Validation, Formal analysis, Data curation.
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PMC11637276
Nonetheless, recent evidence proposed that p38β may have distinct and nonredundant functions .
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PMC9545474
In a second 50 mL two‐neck round‐bottom flask 3,7‐diacetyl‐1,3,7‐triaza‐5‐phosphabicyclo[3.3.1]nonane (DAPTA) (18.3 mg, 0.08 mmol, 1 eq.) was dissolved in dry dichloromethane (10 mL) under nitrogen.
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PMC3122064
An important role of p53 in the response to chemotherapeutic drugs and the execution of apoptosis has been described.
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PMC10553685
M. Musick: None.
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PMC11694625
The intracellular reactive oxygen species generated within MCF-7 cells upon treatment with 3b or 3c were evaluated using fluorescent dye 2,7-dichlorodihydrofluorescein diacetate (DCFH-DA, ROS Assay Kit, Solarbio, Beijing, China) on a flow cytometer.
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PMC11576293
The vitality of the investigated compounds was assessed using the MCF-10 A cell line, a normal human mammary gland epithelial cell line.
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PMC10887351
In the human retina, the expression of the β3-AR protein was primally detected in cultured retinal endothelial and choroidal cells where the stimulation by the agonist promoted cellular growth, migration, invasion and elongation .
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PMC9429973
In case of study participation, information will mainly be obtained from the general practitioner (26.4%) and treating haematologist (39.9%).
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PMC11763126
E CCK-8 assay showing ccRCC cells proliferation after different treatments.
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PMC11650848
Correlation analysis highlighted that a moderate positive correlation (correlation coefficient, 0.423; p = 0.044) can be seen between the two age timepoints for blood methylation (Additional File 2: Table S6 and Fig. S3).
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PMC9429973
No or mild fatigue was reported in patients (80%, n=12/15) on completing PGIS at Week 135, compared with one-third at baseline (n=2/6).
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PMC9429973
The median age was 21.63 years (range: 1-69 years).
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PMC9429973
When landmarked from the HCT date, median OS was not reached in either age group (Figure).
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PMC8751435
Noticeably, approximately 19% of A549 cells accumulated in G0 stage after exposure of CME of 200 μg/ml.
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PMC11740207
LT-HSCs, P_LT-HSCs, and LT-LSCs may originate from MdSCs, VSELSCs, or an intermediate hematopoietic precursor not shown in the model.
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PMC10988555
In the case of complex 4, contrary to complexes 2 and 3, an increase in ΔΨM was observed, indicating that the membrane potential is hyperpolarized, which may be in line with its lower accumulation in the mitochondria (Table 3).
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PMC5386478
TG2 was found to be significantly upregulated at mRNA and protein level after 48 h of cell culture in hypoxia, when compared with normoxia (Figure 2c and d).
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PMC10587429
Human immune cell reconstitution was characterized by multicolor flow cytometry of the blood, spleen and bone marrow at different time points with the gating strategy as shown in Figure 2C .
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PMC11588008
The repair effect of MSCs may be related to the exosome form of MSCs.
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PMC9429973
Results: A total of 229 patients were evaluated (FEDR group: n=70; non-FEDR group: n=159).
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PMC9884169
The total protein was extracted using the ExKine™ Pro Animal Cell/Tissue Total Protein Extraction Kit (Abbkine, USA).
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PMC9429973
A 90-minute short duration infusion (SDI) of obinutuzumab is being evaluated in GAZELLE (NCT03817853), a Phase IV study in pts with previously untreated FL.
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PMC6948907
Data are presented as mean ± standard error of the mean from at least three different experiments.
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PMC10890307
However, most lung cancer cell lines could not proliferate when cultured in the Lac/pH7.2/H condition.
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PMC7685376
Therefore, these findings indicated that the expression of the MCM family was increased in HCC tissues and cell lines.
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PMC11271800
These results indicate that the density of TAMs is related to the poor prognosis of malignant tumors, in which M2 TAMs predominate.
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PMC11474209
This highlights the need for further research on mitigating MC-LR's effects on mitochondrial function and ROS production.
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PMC11680982
For HER2-low weight on day 14: normal saline vs. ET + CDK4/6i, P = 0.217; normal saline vs. standard dose ET + CDK4/6i + Ner, P = 0.0052. (
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PMC11476004
Cytogenetic tests make it possible to identify various types of damage to genetic material, errors occurring during replication and transcription, and DNA strand breaks.
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PMC11674146
In detail, following the confirmation that CLP36 was highly expressed in lymphoma cells, it was additionally observed that CLP36 silencing could lead to the suppression on the proliferation and metastasis potential of lymphoma cells and the enhancement on the apoptosis, which indirectly demonstrated that CLP36 may be a...
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PMC10975211
As research progresses, the development of buforin-containing bioconjugates holds great potential in improving cancer patient outcomes and advancing the field of anticancer therapeutics.
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PMC11352311
First, the CCK-8 assay was applied to assess the inhibition of RCC cell viability by esculin.
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PMC9429973
Annexin V and Eculizumab were used for complement studies.
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PMC11604768
The binding of TFs to TREs and their interaction with enhancers and other distal regulatory elements define how individual genes are regulated transcriptionally.
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PMC11267830
Despite RBM39 degradation after indisulam treatment, we did not observe the depletion of downstream THOC1 (Supplementary Figure 9a).
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PMC11543885
Upload the filtered data to the STRING portal (https://string-db.org/).b.
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PMC11742290
The inconsistency between protein and mRNA results may be due to individual genetic differences among patients which contributes to varied responses to LGR5 expression.
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PMC11380454
The overexpression of NFκB in AML cells abrogated the effect of SAS on PD-L1-induced resistance to chemotherapy, potentially by eliminating the ability of SAS to inhibit PD-L1 expression (Fig. 7E and F).
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PMC11774251
The lysate was then mixed with loading buffer and denatured at 100°C for 10 minutes.
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PMC8540611
Complexes for treatment were incubated for 15 min in PBS using concentrations needed for the delivery of 100 nM of siRNA.
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PMC11401350
T cells (B,D). (
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PMC9429973
The maximum tolerated dose (MTD) was not reached.
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PMC9429973
Results: A total of 576 patients were included (70 were AA, 12%).
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PMC2614416
Furthermore, Didonato and co-workers compared the protein expressions of renal cell carcinoma (RCC) tissues and patient-matched normal kidney tissues with the primary RCC renal cell cultures derived from the tissues, and found that the overall patterns of the profiles of the tissues and cell cultures were similar.
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PMC10758402
FACS analysis of combination treatment in CT26.wt model.
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PMC5925824
Notably, neither mutations (K63 N or N69H) compromise the structural integrity of the ca-PD-L1-Fc protein since the Size Exclusion Chromatography (SEC) profiles of both variants were identical to the SEC profile of the wild type ca-PD-L1-Fc in Additional file 1: Figure S2.
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PMC11604015
Other restrictive antigens such as CD1a, CD21, CD30, CD37, CCR4 and CCR9, are under preclinical and clinical studies .
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PMC11204465
Three new compounds, oxisterigmatocystin J–L (26–28), were isolated from the marine-derived fungus Aspergillus nomius NC06 .
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PMC9429973
Pts had median 2 (range, 0−10) prior lines of therapy (LOT); 5 had untreated CLL (first-line [1L]).
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PMC9429973
W. Yan, J. Xu, H. Fan, J. Liu, L. Li, L. Qiu, G. An State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China Background: Primary plasma cell...
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PMC10114490
C Estimated doubling time for PD and PD iHDF-T (n = 6; three replicates each).
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PMC11676670
The cell line samples were washed three times in PBS buffer, collected, and stored at −20 °C until genetic study.
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PMC11519567
F Representative images of immunofluorescence in the BJ fibroblasts with lentiviral co-expression of SS18-SSX1-mCherry and SS18-EGFP after incubated at 42 °C for 30 min or 1 h. Scale bars, 5 μm.
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PMC11734514
Moreover, the suppression of phosphorylated Akt was observed in A549 cells at 24 hours after treatment (Figure 3D).
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PMC10723784
Significant results were also achieved (p < .01, <.001) when CBG was used at 30 and 50 μM. Pre‐treatment with CBG at 50 μM significantly (p < .001) induced a greater percentage of apoptotic cells in A2780 as compared to cisplatin‐resistant A2780/CP70 cells.
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PMC8998437
Classification of BL cell lines as group type I, type II, or type III was based on the expression of cell surface markers, EBV-encoded proteins (EBNAs and LMPs), and growth patterns .
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PMC7802142
c Western blotting and d quantitative analyses of C-myc and Cyclin D1 in cells were performed 48 h after treatment.
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PMC9429973
In the crossover group, spleen volume decreased by 36.0±3.0% (n=11); %-predicted DLCO increased by 28.0±6.2% (n=10); spleen volume decreased by 36.0±3.0% (n=11); liver volume decreased by 30.7±2.5% (n=11), and platelet count increased by 21.7±6.4% (n=15).
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PMC6901583
Appropriate new approaches for treating the disease (advanced or unresectable cases) are needed.
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PMC11092382
Balloon angioplasty is a general interventional technique applied for treating coronary arteries and endovascular vessel-related disease.
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PMC4360730
For each annotated term in the database, we calculate all the facet terms that slim to it.
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PMC11597291
Increased research interest has been devoted to the functionalization of GO family nanomaterials (including GO, rGO, and CGO) in order to optimize their therapeutic applications .
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PMC9429973
Survival of RS-DLBCL patients previously treated for their CLL is inferior as compared to patients with a previously untreated CLL.
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PMC11387401
Reverse transcriptase (RT) was the sole HIV-1 protein for which no host RNA interactions were identified.
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PMC6643347
Yet another important result of our study was the observation that SBF-HS exhibited maximum efficacy in suppressing an HIV infection in Mϕ. Mϕ, as well as memory T cells, serves as a reservoir of the virus, and this may be the main reason why complete eradication of HIV is impossible (and why lifelong administration of...
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PMC11438317
Densitometry values of the myc blot on the top, expressed as percentage of the WT are indicated below.
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PMC11607321
Specifically, UNC0638, Entinostat, and BIX02189 suppress EMT, while methotrexate shows the ability to induce EMT.
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PMC11092382
The molecular structure (A) and chemical 3D structure (B) of sophocarpine.
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PMC11457557
Chronic hyperglycemia can cause gradual damage to the blood vessels in the retina, resulting in hemorrhage, retinal detachment, and/or blindness.
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PMC9429973
Differences between species exist, particularly in cell types and architecture between human and murine CNS, as well as the lack of specificity of infiltration between leukemia subtypes.
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