OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9693627	An isolation intensity threshold of 50,000 counts was determined for precursor’s selection and up to top 20 precursors were chosen for fragmentation with high-energy collisional dissociation (HCD) at 29 NCE.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10507284	Moreover, the GSE21050 (including 309 STS patients), GSE30929 (including 140 STS patients), and GSE71118 (including 312 STS patients) were applied to validate the association of TROAP with the prognosis of STS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Another exciting therapeutic approach targets the TGF-β pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Another", "exciting", "therapeutic", "approach", "targets", "the", "TGF-β", "pathway", "." ] } ]
PMC7192625	In the case of mESCs, these are the features that were considered in a previous work (25) and include histone modifications, binding peaks of different transcription factors and cytosine modifications (see Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The 1/1, 1/2, 1/3, 1/4, 2/2, 2/3 and 2/4 genotypes of the IL-1RN VNTR polymorphism were statistically compared before treatment between patients having undergone ASCT and healthy controls, as were the 1/1, 1/2 and 2/2 genotypes of IL-4 VNTR polymorphism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6450504	One-way ANOVA with Tukey’s multiple comparisons test. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One-way", "ANOVA", "with", "Tukey", "’s", "multiple", "comparisons", "test", ".", "(" ] } ]
PMC9516401	To the best of our knowledge, although studies have emphasized the anti-oxidant and hypolipidemic effects of HEPV on diabetic mice (Pari and Venkateswaran, 2003 ▶), no study has addressed the potential of HEPV in reducing IDE expression; thus, the current study presents for the first time that the anti-diabetic effect ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10222971	Leishmanicidal activity was strongly dependent on the nature and position of these substituents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Leishmanicidal", "activity", "was", "strongly", "dependent", "on", "the", "...
PMC11798926	Although we did not detect an interaction between μ2 and SynDIG2, we included several deletion mutants in our surface expression studies for comparison.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11583010	We evaluated the spatio–temporal distribution of ETx-22 in tumors after a single-dose injection (10 mg/kg i.v.)	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "evaluated", "the", ...
PMC11727145	The ability of HaCaT cells to form a multilayered epithelium when cultured at the air-liquid interface makes them useful for human skin research and provides a basis for a standardized skin model.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11621493	The cell suspension was passed through a 100 μm filter, centrifuged for 5 min at 180 g, and the cell pellet was resuspended in 1 ml EpiLife growth medium containing above mentioned supplements.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11407042	Here, we present a protocol for detecting the T3SS-mediated cytotoxicity of P. aeruginosa using the A549 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Here", ",", "we", "prese...
PMC9429973	The group that received frontline BTKi followed by CIT/PI based Rx as second line (n=7) was compared to that receiving frontline CIT/PI based Rx followed by BTKi (n=21).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11758416	Follow manufacturer’s protocol for T cell isolation kit or FACS sorting protocol.b.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Follow", "manufacturer", "’s", "protocol", "for", "T", "cell", "isolation",...
PMC11696659	Luis Paz-Ares reports was provided by Fundación CRIS contra el cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Luis", "Paz-Ares", "reports", "was", "provided", "by", "Fundación", "CRIS", "contra", ...
PMC11632064	To confirm this hypothesis, we examined the induction of CXCL8 in MeWo and A-375 cells treated for 72 h with inhibitors targeting PLK1/3, CDK2, FAK, ULK1/2, AURORA/B, CDK16, MET, and JAK3, which are kinases known to bind BI-D1870 (Aronchik et al, 2014).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11672881	This aligns with the previous finding of higher ROS levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "aligns", "with", "the", "previous", "finding", "of", "higher", "ROS", "levels", "....
PMC11696576	Created in BioRender.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Created", "in", "BioRender", "." ] } ]
PMC11283030	c. ACLY knockdown inhibited the proliferative activity of 786-O and A498 cells (CCK-8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "c.", "ACLY", "knockdown", "inhibited", "the"...
PMC11555465	no. ab2307391; 1:10,000; Jackson; Horseradish Peroxidase) at 37°C for 1 h. Finally, the membrane was visualized using an ECL Luminescence Assay Kit (Shanghai Biyuntian Biotechnology Co., Ltd.).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9813422	Although well-known EMPs are usually encoded by viruses, cellular proteins involved in organizing the chromosome architecture of host cells also play a role in viral episome maintenance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9878562	Representative plots of three different flow cytometry analyses. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "plots", "of", "three", "different", "flow", "cytometry", "analyses", ".", "(" ] } ]
PMC11615218	c The metabolic phenotypes and memory status of T cells are interconnected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "c", "The", "metabolic", "phenotypes", "and", "memory", "status", "of", "T", ...
PMC11347429	Functional pathway analysis using GO term enrichment for the down-regulated DEGs from the contrast of infected ICU patients versus healthy controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Functional", "pathway",...
PMC9398137	Adult female NSG mice were used for all experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Adult", "female", "NSG", "mice", "were", "used", "for", "all", "experiments", "." ] } ]
PMC11711127	Thus, Truckenbrod et al. (172) emphasised that tolerance was not binary, an important parameter which sits centre to our proposal for the use of ‘resistance.’	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11583690	Unloaded BPMO and MSN samples were also tested for comparison.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Unloaded", "BPMO", "and", "MSN", "samples", "were", "also", "tested", "for", "comparison", ...
PMC5311252	Expression of AAGUGC-miRNAs and targets were then evaluated in a number of different cancer types using public domain data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", "of", "AAGUGC-miRNAs", ...
PMC10975211	The discovery and development of targeted therapies, nanotechnology-based approaches, and natural peptides like AMPs provide hope for advancing cancer treatment and antimicrobial strategies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9847912	In both CEMss cells and MAGIC-5A indicator cells, viability (as measured using the CellTiter Glo assay) was >90% of the no-drug controls at GSK232 concentrations as high as 100 nM, whereas partial inhibition of CEMss and MAGIC-5A cell growth was observed at 400 nM GSK232 (S1 Fig).	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC10470467	In addition, as shown in Figures 7C,D, we discovered that the mRNA expression of all 3 genes was negatively correlated with methylation expression and positively correlated with the percentage of copy number variation (CNV).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The phase 1b portion evaluated the safety of pirtobrutinib at a continuous dose of 200 mg QD from Cycle 1, Day 1 plus venetoclax starting on Cycle 2, Day 1 with a standard 5-week dose ramp to 400 mg QD (PV) and PV plus rituximab at 375 mg/m2 on Cycle 1, Day 1, then 500 mg/m2 on Day 1 of Cycles 2-6 (PVR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11297139	The protein-bead conjugate was washed stringently for five times using high salt wash buffer and eluted using acidic elution buffer with a composition suggested by manufacturer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11240052	Circular RNAs (circRNAs) are a class of non-coding regulatory RNAs that are mainly formed through the back-splicing of pre-mRNA (7,8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11790971	Based on the multimodal images and corresponding cell masks, cellular features were extracted using the CellProfiler software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "the", "multimodal", "im...
PMC11564322	Therefore, the aim of our study was to investigate the mechanism of action of EDPs (VGVAPG and VVGPGA peptides) in cancerous cells derived from the immunological system, i.e., the HL-60, K562, and MEG-A2 cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8164677	CI=D1/D1x + D2/D2x Since the platinum drugs are assumed to act through DNA binding, platinum accumulation was measured to determine if there was any correlation between the combined drug action and the level of platinum.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11583010	In an effort to improve on the therapeutic window of the currently approved nectin-4 ADC, the main objective of this project was to develop a second-generation ADC against nectin-4 with optimized linker payload stability, higher DAR, and differentiated payload to yield improved clinical efficacy and safety.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11759751	Results of a meta-analysis of R/R DLBCL treated with CD19 CAR T cell therapy showed a CR rate of 49.2% in the CD19 CAR T cell therapy group of 263 patients included .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770199	mMSCs-GFP (2 × 10), mMSCs-p14 (2 × 10), or normal saline was administrated intratumorally into these mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "mMSCs-G...
PMC11297139	e Odds ratio that an activated gene is included in the cancer-related GO terms shown in Fig. 4c, comparing the genes linked to the upregulated cREs versus unlinked genes (P values for the enrichment of the linked genes versus the unlinked genes: migration = 0.034, cell adhesion = 0.038, two-sided Fisher’s exact test).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10454535	Our results suggest that this combination of BTZ and PIN decreases MM cell viability synergistically by inducing apoptosis and oxidative stress in MM cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC5415764	Anti-rabbit GAPDH antibody was used as internal reference.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Anti-rabbit", "GAPDH", "antibody", "was", "used", "as", "internal", "reference", "." ] } ]
PMC9429973	The median time of neutrophil engraftment (14 days,14days,13.5days, respectively) and platelet engraftment(13 days, 13days, 12days, respectively) were not significantly different between the three groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6627640	Cells were treated with the indicated dosages of cisplatin for 6 h and cells assayed for survival 3 days later (Figure 1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11401350	The T cells were activated through the T cell receptor (TCR) with anti-mCD3 and anti-mCD28 antibodies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "T", "cells", "were", "activated...
PMC9646302	In conclusion, these results indicate that LAPTM5 may be a new therapeutic target for ccRCC via activation of the RAC1-JNK/p38 axis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "conclu...
PMC9964654	This strategic approach allows healthy cells to be spared undesired effects, while drug effectiveness and pharmacokinetic profiles can be improved .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "strategic", ...
PMC11361748	Quantitation of neutrophil fluorescence signal (surface area measurements) from (C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantitation", "of", "neutrophil", "fluorescence", "signal", "(", "sur...
PMC10237474	Hence, alternative and complementary cell lines are required to address these issues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",", "alternative", "and", "complementary", "cell", "lines", "are",...
PMC11322866	SA-β-gal staining was performed using an SA-β-gal staining kit (C0602; Beyotime).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SA-β-gal", "staining", "was", "performed", "using", "an", "SA-β-gal", ...
PMC11532793	In all analyses, transcripts were considered to be differentially expressed (DE) under an FDR control of 0.05.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "all", "analyses", ...
PMC11310713	The ovary is an organ having a small and oval-like shape and contains ovarian follicles inside.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ovary", "is", "an", "organ", "having", "a...
PMC9622879	The pricing in this study is the MMR pricing, which is adopted from.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "pricing", "in", "this", "study", "is", "the", "MMR", ...
PMC10958426	Volcano plot of DEGs between tumor subclones in each patient.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Volcano", "plot", "of", "DEGs", "between", "tumor", "subclones", "in", "each", "patient", ...
PMC10114490	B ROC curve with 95% confidence interval (shadowed) of the 10-times repeated threefold CV for (top) diHLC-T and (bottom) HepG2 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellL...
PMC11711347	In a separate 100 mL Erlenmeyer flask, 5 mmol of proline was dissolved in 10 mL of 95% ethanol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "a", "separa...
PMC10094992	A close inspection of the NR6-ALDH1A3 crystallographic structure revealed that NR6 binds the tyrosine residue 472 (Y472) of ALDH1A3, which is non-conserved in all the other human ALDH1A isoenzymes, and this drives its selectivity against this isoform.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10713411	are being discovered and studied.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "are", "being", "discovered", "and", "studied", "." ] } ]
PMC10047551	The prognostic value of PD-L1 methylation has shown conflicting results, as both high and low PD-L1 promoter methylation have been associated with shorter overall survival .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11711871	The initial decrease in Na and K excretion in the GR rats on a NSD might indicate an altered tubular GR activity that is not observed on HSD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11629461	The cell transfection reagent jetPRIME® (#101000046) was bought from Polyplus‐Transfection (Illkirch, France).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "transfection", "re...
PMC11768927	The co-administration of these recombinant viruses enhanced T-cell activation, reduced metastases, and improved survival in mouse breast cancer models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "co-administratio...
PMC7504302	These attributes granted mesothelin the Food and Drug Administration (FDA) approval for the diagnosis of MPM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "attributes", "granted", "mesothelin...
PMC11536589	The KPC210 cell lines were isolated in our laboratory from a spontaneous LSL-KRAS, LSL-TRP53, PDX1-CRE (KPC) tumor following previously established protocols (Kamerkar et al. 2017; Zheng et al. 2015).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11708541	Results confirmed that the instantaneous cortical LSCI and ECoG approach provided temporal and spatial information on the ictogenesis process and enabled the evaluation of pharmaceutical treatments' effectiveness in treating several types of epileptic seizures in vivo models (Fig. 14).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10376064	Several studies in animal models have previously reported beneficial effects of DMF treatment on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-(MPTP)- or Aβ-mediated neurotoxicity , stroke, intracerebral hemorrhage , as well as learning and memory in streptozotocin-induced rat models .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Enrollment is planned to start by June 2022.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Enrollment", "is", "planned", "to", "start", "by", "June", "2022", "." ] } ]
PMC11732628	miR-490-3p, micro RNA-490-3p; TUNEL, transferase dUTP nick end labelling; NC, negative control; DAPI, 4’,6-diamidino-2-phenylindole; ns, no significance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10706275	Our initial step involved demonstrating the viability of this approach by incorporating HSA into the NC_048595.1 within the CHO-K1 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Our", "initial", "s...
PMC9429973	Results: Here we show that regulation of lipid homeostasis by lipin1 is required for HSPC and LSC function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Here", "we", ...
PMC10926885	Tumour purity statistics for several tumours were previously summarised by Thorsson et al. The connection between tumour purity and NDE1 expression levels was then determined by integrating these data with NDE1 expression levels in the relevant samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721295	Together, these data reveal an epithelial KRAS-dependent secretome containing tumor-promoting and immunosuppressive components that may provide future therapeutic targets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Together", ",", "these", ...
PMC11774251	Red dots indicate individual records in the control group and blue dots indicate individual records in the Tan-I treated group. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Red", "dots", "in...
PMC11277157	For partitioning the DJ-1 dependent transcriptomic signature from that of the siRNA response perse (i.e., siRNA RULC), we also show in a unified network the genes identified by the siRNA RULC and the KD DJ-1 set (Supplementary Figure S2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: From March 2018 to September 2021, 196 patients included in 64 centers started VEN as monotherapy for CLL (tolerance population), 195 met the selection criteria (analysis population) and 113 could be evaluated (evaluable population).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8735881	The sequence of a fusion inhibitor peptide P41 was genetically connected to the N- or C-termini of 10E8 scFv through a flexible (GGGGS)n linker, generating eight GPI-anchored bifunctional constructs named CMI01 ∼ CMI08. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11295144	The α4β3δ-GABAARs are generally localized outside of GABAergic synapses and they mediate tonic inhibition (Farrant and Nusser, 2005).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "α4β3δ-GABAARs", ...
PMC11770199	Later, cDNA was subjected to qPCR analysis using ChamQ SYBR qPCR Master Mix (#Q331-02, Vazyme).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Later", ",",...
PMC9545714	Mutations of enzymes that are uniquely involved in acylceramide synthesis result in various autosomal recessive congenital ichthyoses with impaired barrier function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mutations", "of", ...
PMC11519583	d Representative images of MPs at 3 days after transfection with the respective siRNAs, followed by staining with SPiDER-βGal (magenta) and DAPI (cyan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In univariate analysis no factors were significantly associated with OS after HSCT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "univariate", "analysis", "no", "factors", "were", "significantly", "associated",...
PMC11657744	During centriole maturation, distinct morphological changes occur at the distal ends of centrioles, where the vicinity of the triple microtubule transitions to a doublets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11653168	This additional work will provide more direct evidence of STAT3 dependency.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "additional", "work", "will", "provide", "more", "direct", "evidence", "of", "...
PMC9429973	Patients in the ST group were significantly older, had a lower WBC count, peripheral blast count and lactate dehydrogenase level at diagnosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Since there were no genetic test results for the children before 2010, only the 105 patients after 2010 had gene sequencing results, which allowed genotyping.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680562	On the other hand, xanthan gum, a polysaccharide, improves the gel's stability and viscosity, thereby establishing a homogenous and durable matrix for incorporating 5-Fu and CuO NPs .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8633974	Phalloidin-iFluor 647 marked cell boundaries.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Phalloidin-iFluor", "647", "marked", "cell", "boundaries", "." ] } ]
PMC7153288	MTT assay and flow cytometry analysis were performed on the A549 cell line to evaluate the cytotoxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MTT", "assay", "and", "flow", "cytometry...
PMC11525293	Overall, we propose the dual effect of thalidomide in reducing SARS-CoV-2 viral re-entry and inflammation through p63 degradation to weaken SARS-CoV-2 entry into host cells and mitigate lung inflammation, making it a valuable option in clinical management of COVID-19.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770746	Oxaliplatin, which is used to treat metastatic colon cancer, elicits symptomatic neurotoxicity in more than 70% of the patients, often leading to discontinuation of the treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365983	A–C) Western immunoblot analysis demonstrates that meningeal expression of core Hh components is dysregulated by Foxc1 mutation. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "–", "C", ...
PMC9429973	147 (92%) and 149 (94%) patients completed treatment with ibrutinib and venetoclax, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "147", "(", "92", "%", ...
PMC11188874	Similar results were observed in HeLa cells following HDAC6 KO (Fig. 5C).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar", "results", "were", "observed", "in", "HeLa", "cells...
PMC11806106	C, D Half-time of activation (C) or deactivation (D) were evaluated by a one-phase mono-exponential fit based on (A, B) and Supplementary Fig. 4A–F (mean ± SEM, significance calculated against DAMGO, Brown–Forsyth & Welch’s ANOVA, P values: MetEnk C: 0.4637, D: 0.4374; Fentanyl C: <0.0001, D: 0.3526; Methadone C: 0.005...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10994876	The findings from this assay, presented in Fig. 5, reveal that the apoptosis rate was reduced when there was an overexpression of YAP5SA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10253553	Given that concurrent inhibition of mTORC1 and mTORC2 by Torin 2 non-selectively reduced the viability of HK2 and 786-0 cells, we tested whether selective inhibition of mTORC2 would reduce the viability of 786-0 cells without reducing the viability of HK2 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", ...
PMC11291697	3Overstimulation of NMDA receptors due to GLDC downregulation and glycine accumulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3Overstimulation", "of", "NMDA", "receptors", "due", "to", "GLDC", "downregulation", "and",...
PMC11243198	Further, BAS 07019774 was more effective in reducing U87MG cell viability in comparison to GANT61, while their effects on TG98 cells were comparable (Figure 5B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O"...

PMC9693627

An isolation intensity threshold of 50,000 counts was determined for precursor’s selection and up to top 20 precursors were chosen for fragmentation with high-energy collisional dissociation (HCD) at 29 NCE.

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PMC10507284

Moreover, the GSE21050 (including 309 STS patients), GSE30929 (including 140 STS patients), and GSE71118 (including 312 STS patients) were applied to validate the association of TROAP with the prognosis of STS.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Another exciting therapeutic approach targets the TGF-β pathway.

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PMC7192625

In the case of mESCs, these are the features that were considered in a previous work (25) and include histone modifications, binding peaks of different transcription factors and cytosine modifications (see Table 1).

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PMC9429973

The 1/1, 1/2, 1/3, 1/4, 2/2, 2/3 and 2/4 genotypes of the IL-1RN VNTR polymorphism were statistically compared before treatment between patients having undergone ASCT and healthy controls, as were the 1/1, 1/2 and 2/2 genotypes of IL-4 VNTR polymorphism.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6450504

One-way ANOVA with Tukey’s multiple comparisons test. (

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PMC9516401

To the best of our knowledge, although studies have emphasized the anti-oxidant and hypolipidemic effects of HEPV on diabetic mice (Pari and Venkateswaran, 2003 ▶), no study has addressed the potential of HEPV in reducing IDE expression; thus, the current study presents for the first time that the anti-diabetic effect ...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10222971

Leishmanicidal activity was strongly dependent on the nature and position of these substituents.

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PMC11798926

Although we did not detect an interaction between μ2 and SynDIG2, we included several deletion mutants in our surface expression studies for comparison.

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PMC11583010

We evaluated the spatio–temporal distribution of ETx-22 in tumors after a single-dose injection (10 mg/kg i.v.)

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "evaluated", "the", ...

PMC11727145

The ability of HaCaT cells to form a multilayered epithelium when cultured at the air-liquid interface makes them useful for human skin research and provides a basis for a standardized skin model.

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PMC11621493

The cell suspension was passed through a 100 μm filter, centrifuged for 5 min at 180 g, and the cell pellet was resuspended in 1 ml EpiLife growth medium containing above mentioned supplements.

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PMC11407042

Here, we present a protocol for detecting the T3SS-mediated cytotoxicity of P. aeruginosa using the A549 cell line.

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PMC9429973

The group that received frontline BTKi followed by CIT/PI based Rx as second line (n=7) was compared to that receiving frontline CIT/PI based Rx followed by BTKi (n=21).

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PMC11758416

Follow manufacturer’s protocol for T cell isolation kit or FACS sorting protocol.b.

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PMC11696659

Luis Paz-Ares reports was provided by Fundación CRIS contra el cancer.

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PMC11632064

To confirm this hypothesis, we examined the induction of CXCL8 in MeWo and A-375 cells treated for 72 h with inhibitors targeting PLK1/3, CDK2, FAK, ULK1/2, AURORA/B, CDK16, MET, and JAK3, which are kinases known to bind BI-D1870 (Aronchik et al, 2014).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...

PMC11672881

This aligns with the previous finding of higher ROS levels.

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PMC11696576

Created in BioRender.

[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Created", "in", "BioRender", "." ] } ]

PMC11283030

c. ACLY knockdown inhibited the proliferative activity of 786-O and A498 cells (CCK-8).

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PMC11555465

no. ab2307391; 1:10,000; Jackson; Horseradish Peroxidase) at 37°C for 1 h. Finally, the membrane was visualized using an ECL Luminescence Assay Kit (Shanghai Biyuntian Biotechnology Co., Ltd.).

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PMC9813422

Although well-known EMPs are usually encoded by viruses, cellular proteins involved in organizing the chromosome architecture of host cells also play a role in viral episome maintenance.

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PMC9878562

Representative plots of three different flow cytometry analyses. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "plots", "of", "three", "different", "flow", "cytometry", "analyses", ".", "(" ] } ]

PMC11615218

c The metabolic phenotypes and memory status of T cells are interconnected.

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PMC11347429

Functional pathway analysis using GO term enrichment for the down-regulated DEGs from the contrast of infected ICU patients versus healthy controls.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Functional", "pathway",...

PMC9398137

Adult female NSG mice were used for all experiments.

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PMC11711127

Thus, Truckenbrod et al. (172) emphasised that tolerance was not binary, an important parameter which sits centre to our proposal for the use of ‘resistance.’

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PMC11583690

Unloaded BPMO and MSN samples were also tested for comparison.

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PMC5311252

Expression of AAGUGC-miRNAs and targets were then evaluated in a number of different cancer types using public domain data.

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PMC10975211

The discovery and development of targeted therapies, nanotechnology-based approaches, and natural peptides like AMPs provide hope for advancing cancer treatment and antimicrobial strategies.

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PMC9847912

In both CEMss cells and MAGIC-5A indicator cells, viability (as measured using the CellTiter Glo assay) was >90% of the no-drug controls at GSK232 concentrations as high as 100 nM, whereas partial inhibition of CEMss and MAGIC-5A cell growth was observed at 400 nM GSK232 (S1 Fig).

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PMC10470467

In addition, as shown in Figures 7C,D, we discovered that the mRNA expression of all 3 genes was negatively correlated with methylation expression and positively correlated with the percentage of copy number variation (CNV).

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PMC9429973

The phase 1b portion evaluated the safety of pirtobrutinib at a continuous dose of 200 mg QD from Cycle 1, Day 1 plus venetoclax starting on Cycle 2, Day 1 with a standard 5-week dose ramp to 400 mg QD (PV) and PV plus rituximab at 375 mg/m2 on Cycle 1, Day 1, then 500 mg/m2 on Day 1 of Cycles 2-6 (PVR).

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PMC11297139

The protein-bead conjugate was washed stringently for five times using high salt wash buffer and eluted using acidic elution buffer with a composition suggested by manufacturer.

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PMC11240052

Circular RNAs (circRNAs) are a class of non-coding regulatory RNAs that are mainly formed through the back-splicing of pre-mRNA (7,8).

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PMC11790971

Based on the multimodal images and corresponding cell masks, cellular features were extracted using the CellProfiler software.

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PMC11564322

Therefore, the aim of our study was to investigate the mechanism of action of EDPs (VGVAPG and VVGPGA peptides) in cancerous cells derived from the immunological system, i.e., the HL-60, K562, and MEG-A2 cell lines.

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PMC8164677

CI=D1/D1x + D2/D2x Since the platinum drugs are assumed to act through DNA binding, platinum accumulation was measured to determine if there was any correlation between the combined drug action and the level of platinum.

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PMC11583010

In an effort to improve on the therapeutic window of the currently approved nectin-4 ADC, the main objective of this project was to develop a second-generation ADC against nectin-4 with optimized linker payload stability, higher DAR, and differentiated payload to yield improved clinical efficacy and safety.

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PMC11759751

Results of a meta-analysis of R/R DLBCL treated with CD19 CAR T cell therapy showed a CR rate of 49.2% in the CD19 CAR T cell therapy group of 263 patients included .

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PMC11770199

mMSCs-GFP (2 × 10), mMSCs-p14 (2 × 10), or normal saline was administrated intratumorally into these mice.

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PMC11297139

e Odds ratio that an activated gene is included in the cancer-related GO terms shown in Fig. 4c, comparing the genes linked to the upregulated cREs versus unlinked genes (P values for the enrichment of the linked genes versus the unlinked genes: migration = 0.034, cell adhesion = 0.038, two-sided Fisher’s exact test).

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PMC10454535

Our results suggest that this combination of BTZ and PIN decreases MM cell viability synergistically by inducing apoptosis and oxidative stress in MM cells.

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PMC5415764

Anti-rabbit GAPDH antibody was used as internal reference.

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PMC9429973

The median time of neutrophil engraftment (14 days,14days,13.5days, respectively) and platelet engraftment(13 days, 13days, 12days, respectively) were not significantly different between the three groups.

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PMC6627640

Cells were treated with the indicated dosages of cisplatin for 6 h and cells assayed for survival 3 days later (Figure 1B).

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PMC11401350

The T cells were activated through the T cell receptor (TCR) with anti-mCD3 and anti-mCD28 antibodies.

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PMC9646302

In conclusion, these results indicate that LAPTM5 may be a new therapeutic target for ccRCC via activation of the RAC1-JNK/p38 axis.

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PMC9964654

This strategic approach allows healthy cells to be spared undesired effects, while drug effectiveness and pharmacokinetic profiles can be improved .

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PMC11361748

Quantitation of neutrophil fluorescence signal (surface area measurements) from (C).

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PMC10237474

Hence, alternative and complementary cell lines are required to address these issues.

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PMC11322866

SA-β-gal staining was performed using an SA-β-gal staining kit (C0602; Beyotime).

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PMC11532793

In all analyses, transcripts were considered to be differentially expressed (DE) under an FDR control of 0.05.

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PMC11310713

The ovary is an organ having a small and oval-like shape and contains ovarian follicles inside.

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PMC9622879

The pricing in this study is the MMR pricing, which is adopted from.

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PMC10958426

Volcano plot of DEGs between tumor subclones in each patient.

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PMC10114490

B ROC curve with 95% confidence interval (shadowed) of the 10-times repeated threefold CV for (top) diHLC-T and (bottom) HepG2 cells.

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PMC11711347

In a separate 100 mL Erlenmeyer flask, 5 mmol of proline was dissolved in 10 mL of 95% ethanol.

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PMC10094992

A close inspection of the NR6-ALDH1A3 crystallographic structure revealed that NR6 binds the tyrosine residue 472 (Y472) of ALDH1A3, which is non-conserved in all the other human ALDH1A isoenzymes, and this drives its selectivity against this isoform.

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PMC10713411

are being discovered and studied.

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PMC10047551

The prognostic value of PD-L1 methylation has shown conflicting results, as both high and low PD-L1 promoter methylation have been associated with shorter overall survival .

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PMC11711871

The initial decrease in Na and K excretion in the GR rats on a NSD might indicate an altered tubular GR activity that is not observed on HSD.

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PMC11629461

The cell transfection reagent jetPRIME® (#101000046) was bought from Polyplus‐Transfection (Illkirch, France).

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PMC11768927

The co-administration of these recombinant viruses enhanced T-cell activation, reduced metastases, and improved survival in mouse breast cancer models.

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PMC7504302

These attributes granted mesothelin the Food and Drug Administration (FDA) approval for the diagnosis of MPM.

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PMC11536589

The KPC210 cell lines were isolated in our laboratory from a spontaneous LSL-KRAS, LSL-TRP53, PDX1-CRE (KPC) tumor following previously established protocols (Kamerkar et al. 2017; Zheng et al. 2015).

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PMC11708541

Results confirmed that the instantaneous cortical LSCI and ECoG approach provided temporal and spatial information on the ictogenesis process and enabled the evaluation of pharmaceutical treatments' effectiveness in treating several types of epileptic seizures in vivo models (Fig. 14).

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PMC10376064

Several studies in animal models have previously reported beneficial effects of DMF treatment on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-(MPTP)- or Aβ-mediated neurotoxicity , stroke, intracerebral hemorrhage , as well as learning and memory in streptozotocin-induced rat models .

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PMC9429973

Enrollment is planned to start by June 2022.

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PMC11732628

miR-490-3p, micro RNA-490-3p; TUNEL, transferase dUTP nick end labelling; NC, negative control; DAPI, 4’,6-diamidino-2-phenylindole; ns, no significance.

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PMC10706275

Our initial step involved demonstrating the viability of this approach by incorporating HSA into the NC_048595.1 within the CHO-K1 cells.

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PMC9429973

Results: Here we show that regulation of lipid homeostasis by lipin1 is required for HSPC and LSC function.

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PMC10926885

Tumour purity statistics for several tumours were previously summarised by Thorsson et al. The connection between tumour purity and NDE1 expression levels was then determined by integrating these data with NDE1 expression levels in the relevant samples.

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PMC11721295

Together, these data reveal an epithelial KRAS-dependent secretome containing tumor-promoting and immunosuppressive components that may provide future therapeutic targets.

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PMC11774251

Red dots indicate individual records in the control group and blue dots indicate individual records in the Tan-I treated group. (

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PMC11277157

For partitioning the DJ-1 dependent transcriptomic signature from that of the siRNA response perse (i.e., siRNA RULC), we also show in a unified network the genes identified by the siRNA RULC and the KD DJ-1 set (Supplementary Figure S2).

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PMC9429973

Results: From March 2018 to September 2021, 196 patients included in 64 centers started VEN as monotherapy for CLL (tolerance population), 195 met the selection criteria (analysis population) and 113 could be evaluated (evaluable population).

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PMC8735881

The sequence of a fusion inhibitor peptide P41 was genetically connected to the N- or C-termini of 10E8 scFv through a flexible (GGGGS)n linker, generating eight GPI-anchored bifunctional constructs named CMI01 ∼ CMI08. (

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PMC11295144

The α4β3δ-GABAARs are generally localized outside of GABAergic synapses and they mediate tonic inhibition (Farrant and Nusser, 2005).

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PMC11770199

Later, cDNA was subjected to qPCR analysis using ChamQ SYBR qPCR Master Mix (#Q331-02, Vazyme).

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PMC9545714

Mutations of enzymes that are uniquely involved in acylceramide synthesis result in various autosomal recessive congenital ichthyoses with impaired barrier function.

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PMC11519583

d Representative images of MPs at 3 days after transfection with the respective siRNAs, followed by staining with SPiDER-βGal (magenta) and DAPI (cyan).

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PMC9429973

In univariate analysis no factors were significantly associated with OS after HSCT.

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PMC11657744

During centriole maturation, distinct morphological changes occur at the distal ends of centrioles, where the vicinity of the triple microtubule transitions to a doublets.

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PMC11653168

This additional work will provide more direct evidence of STAT3 dependency.

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PMC9429973

Patients in the ST group were significantly older, had a lower WBC count, peripheral blast count and lactate dehydrogenase level at diagnosis.

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PMC9429973

Since there were no genetic test results for the children before 2010, only the 105 patients after 2010 had gene sequencing results, which allowed genotyping.

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PMC11680562

On the other hand, xanthan gum, a polysaccharide, improves the gel's stability and viscosity, thereby establishing a homogenous and durable matrix for incorporating 5-Fu and CuO NPs .

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PMC8633974

Phalloidin-iFluor 647 marked cell boundaries.

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PMC7153288

MTT assay and flow cytometry analysis were performed on the A549 cell line to evaluate the cytotoxicity.

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PMC11525293

Overall, we propose the dual effect of thalidomide in reducing SARS-CoV-2 viral re-entry and inflammation through p63 degradation to weaken SARS-CoV-2 entry into host cells and mitigate lung inflammation, making it a valuable option in clinical management of COVID-19.

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PMC11770746

Oxaliplatin, which is used to treat metastatic colon cancer, elicits symptomatic neurotoxicity in more than 70% of the patients, often leading to discontinuation of the treatment.

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PMC11365983

A–C) Western immunoblot analysis demonstrates that meningeal expression of core Hh components is dysregulated by Foxc1 mutation. (

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PMC9429973

147 (92%) and 149 (94%) patients completed treatment with ibrutinib and venetoclax, respectively.

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PMC11188874

Similar results were observed in HeLa cells following HDAC6 KO (Fig. 5C).

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PMC11806106

C, D Half-time of activation (C) or deactivation (D) were evaluated by a one-phase mono-exponential fit based on (A, B) and Supplementary Fig. 4A–F (mean ± SEM, significance calculated against DAMGO, Brown–Forsyth & Welch’s ANOVA, P values: MetEnk C: 0.4637, D: 0.4374; Fentanyl C: <0.0001, D: 0.3526; Methadone C: 0.005...

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PMC10994876

The findings from this assay, presented in Fig. 5, reveal that the apoptosis rate was reduced when there was an overexpression of YAP5SA.

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PMC10253553

Given that concurrent inhibition of mTORC1 and mTORC2 by Torin 2 non-selectively reduced the viability of HK2 and 786-0 cells, we tested whether selective inhibition of mTORC2 would reduce the viability of 786-0 cells without reducing the viability of HK2 cells.

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PMC11291697

3Overstimulation of NMDA receptors due to GLDC downregulation and glycine accumulation.

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PMC11243198

Further, BAS 07019774 was more effective in reducing U87MG cell viability in comparison to GANT61, while their effects on TG98 cells were comparable (Figure 5B).

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