OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC5600151	As one example of this studies, Al-Jamal and co-workers investigated the potential of these dendrimers as DOX carriers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "one", "example", "of", ...
PMC8414691	Remarkably, SRCAP depletion perturbs both mitosis and cytokinesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Remarkably", ",", "SRCAP", "depletion", "perturbs", "both", "mitosis", "and", "cytokinesis", "." ] } ...
PMC11240448	Because our own experimental verification was beyond the scope of this work, we computationally demonstrated robustness of cSTAR predictions and reported clinical and biochemical data that support them.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11748335	B The heatmap shows the top 20 LOLA terms most significantly enriched in peaks within short LOCKs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "The", "heatmap", "shows", "the", "top"...
PMC11750161	Interestingly, our results in the presented study are no activity, in contrast to previously reported data for equine LH/CGR-t656 (Byambaragchaa et al., 2022b), equine FSHR-t641 (Seong et al., 2020), and eel FSHR-t614 (Kim et al., 2018), showing that agonist-induced receptors are not completely impaired in the cAMP res...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11673128	Therefore, the interplay between CD47 and CALR underscores their integral roles in modulating immune responses and presents promising avenues for therapeutic strategies, which should be oriented to selectively upregulate CALR and quench CD47 signaling on cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10788478	It is also possible that LGR6 expression is a prognostic marker for lung adenocarcinomas without EGFR mutations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "also", "possible", "that", "LGR...
PMC11472569	ABCG2 is highly expressed in the placenta, blood-brain barrier, liver, and intestine, and is notably prevalent in various stem cells, including hematopoietic stem cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11659921	Furthermore, we validated the model with the GSE14764 dataset, and the results were consistent with those obtained from the TCGA‐BLCA dataset (Figure 5F–H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697189	Negative correlation with risk score.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Negative", "correlation", "with", "risk", "score", "." ] } ]
PMC9429973	Until now, little information exists on the genomic analysis of LCH with thyroid gland involvement with or without coexisting papillary thyroid carcinoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Until",...
PMC10877303	Shahriar Zaman: Writing – review & editing, Resources, Project administration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Shahriar", "Zaman", ":", "Writing", "–", "review", "&", "editing", ",...
PMC10926885	In addition, we used the TISMO database to examine NDE1 expression levels in cell lines that received different treatments and found that after IFNg treatment, The expression levels of NDE1 in B16_SSG33589424, CT26_RTM28723893 and EMT6_XW33589424 cohorts were significantly lower than those in other treatment groups and...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10565698	P < 0.05, : P < 0.01, *: P < 0.001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "<", "0.05", ",", "", "", ...
PMC11012012	SLAMF2/CD48, SLAMF8/CD353, and SLAMF9/CD84-H1 can be designated as atypical SLAMF receptors due to differences in their cytoplasmic domains in comparison with the other SLAMF receptors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11388384	Quantification of signaling gradients formed in the presence of Latrunculin A. Hedgehog (HH) family morphogens are at the forefront of this debate partly because of their lipophilic nature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742864	Currently, although surgery is still the first and standard choice for patients with NSCLC, less than 30% of patients receive this treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Patients with severe congenital neutropenia (SCN) were excluded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "with", "severe", "congenital", "neutropenia", "(", "SCN", ")", "were", "excluded", ...
PMC11471176	Chromogen Solution A and B were added to each well, gently mixed, and incubated at 37 °C for 15 min in the absence of light to avoid sample exposure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	E. A. Martino, C. Conticello, E. Zamagni, V. Pavone, S. Palmieri, M. Musso, P. Tacchetti, A. Mele, L. Catlano, E. Vigna, A. Bruzzese, F. Mendicino, C. Botta, D. Vincelli, G. Farina, M. Barone, C. Cangialosi, K. Mancuso, I. Rizziello, S. Rocchi, A. P. Falcone, G. Mele, G. Reddiconto, B. Garibaldi, E. Iaccino, G. Tripepi...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11679892	The increase in absorbance observed spectrophotometrically is directly proportional to the oxidant molecules in the sample .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "increase", "in", "absorbance", "observed", "spe...
PMC11412752	This indicates that STING exerts an antibacterial effect in HepG2 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "This", "indicates", "that", "STING", "exerts", "an", "antibacterial", "effect", "i...
PMC11055510	In previous studies, miR-135a-3p was found to be down-regulated in OC patients and tissues and thus it could be considered a tumor suppressor, biomarker, and nucleic acid therapeutic agent in OC (Duan et al., 2018; Fukagawa et al., 2017).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9954564	Sequencing libraries were prepared according to the manufacturer’s instructions using a customized Haloplex Target Enrichment System (Agilent Technologies, Inc., Santa Clara, CA, USA) protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11700165	The PH-domain plays a key role in activating TFKs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "PH-domain", "plays", "a", "key", "role", "in", "activating", "TFKs", "." ] } ]
PMC11588085	Scheme of XIST KD in ovarian cancer cell line using CRISPRi technology. (	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Scheme", "of", "XIST", "KD", "in", "ovarian", ...
PMC11489275	Lymphocyte count is a cheap-cost, widely available, easy-to-obtain marker of inflammation, which makes it more convenient for clinical use.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lymphocyte", ...
PMC11629143	RT‐qPCR experiments were repeated using cell pools from three biological repeats.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RT‐qPCR", "experiments", "were", "repeated", "using", "cell", "pools", "from", "three", ...
PMC7757104	Notably, OPNc cells exhibited increased sensitivity to CDDP compared with that in the control cells, which may be associated with CDDP-induced OPNc downregulation.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC11549062	Overall, these results suggest that the accumulation of PDGFR‐β is associated with plaque apoptosis, which potentially leads to carotid plaque vulnerability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overall...
PMC11180402	These results demonstrate that SOX2 downregulation contributes to the ISO-mediated inhibition of BMIBC invasion and anchorage-independent growth in 5637 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "These", "results", ...
PMC5025404	Moreover, all clones grew slowly (doubling time 40–50 h), and the best one, #30, reached the maximum cell density at 12.3 × 10 cells/mL. As a result, fed-batch in shaker flasks gave the effective productivity of only 0.4 g/L (this value indicates the yield after the first purification step).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11683240	The absorbance was measured using a plate reader at 490 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "absorbance", "was", "measured", "using", "a", "plate", "reader", "at", "490", ...
PMC11791478	Additional characterizations of 25A3 have been reported (16).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additional", "characterizations", "of", "25A3", "have", "been", "reported", "(", "16", ")", ...
PMC9429973	Aims: The primary objectives of this multicenter, open-label, phase 1, dose-escalation and dose-expansion study were to evaluate the safety and tolerability of escalating doses of CC-95251 + ritux and to define the maximum tolerated dose (MTD) and/or recommended phase 2 dose for the combination in patients (pts) with C...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11588085	It has been proposed that XIST lncRNA can be used as a biomarker for treatment and prognostic marker in breast and testicular cancer (20, 26).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11397654	Preliminary cytotoxicity assays performed on six cancer cell lines (A549, SKOV3, SW1990, Hela, Raji, MDA-MB-231) indicated that the larger macrocycles, i.e., the calixarene and calixarene derivatives, were generally inactive, likely due to their inability to permeate the cell membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", ...
PMC11657744	After washing, membranes were incubated with secondary antibodies for 3 h. Signal detection was performed using a chemiluminescent reagent (Millipore).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After",...
PMC11791478	The safety profile was further validated in nonhuman primate studies, in which treatment with XB002 did not impact clotting times or cause bleeding, supporting its potential for safe clinical use.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607764	To explore the associations between PTBP1 and immune cell infiltration, we employed TIMER2.0, a useful resource for comprehensive analysis of tumor-infiltrating immune cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	L. E. Roeker, A. R. Mato, J. R. Brown, C. C. Coombs, N. N. Shah, W. G. Wierda, M. R. Patel, K. L. Lewis, M. Balbas, J. Zhao, N. C. Ku, J. F. Kherani, D. E. Tsai, B. Nair, C. Y. Cheah Memorial Sloan Kettering Cancer Center, New York; Dana-Farber Cancer Institute and Harvard Medical School, Boston; University of North Ca...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6024716	The mass spectra were acquired using a Turbo Spray Ionization of 2500 V in positive ion mode, and multiple reaction monitoring (MRM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Systemic chronic inflammation, thrombocytosis, abnormal platelet functions, proinflammatory cytokines, hypertension, obesity, diabetes, and dyslipidemia contribute to the elevated risk of thromboembolic events.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11481779	In the case of the higher blur, with σ = 3, we are getting a much more augmented matrix - and the FID score rises to 61.5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6160470	Pellets were lysed with RIPA buffer supplemented with complete protease inhibitor (Sigma-Aldrich, USA) and subsequently sonicated using Bioruptor sonicator (Diagenode).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11186948	Patient #249 was clinically and phenotypically evaluated by an expert clinical geneticist (DM) who proposed a clinical diagnosis of RSTS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patient...
PMC9027909	They showed a significant higher protease activity of Blastocystis sp., ST3 isolated from symptomatic subjects compared to those isolated from asymptomatic individuals .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", ...
PMC10988555	The culture media was recovered to a new tube (supernatant fraction) and cells were detached from the T-flask with 2 mL of TripLE Express (TE) (Gibco by life technologies) and centrifuged at 750 × g for 5 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8806312	GO and KEGG pathways were analyzed and visualized by the clusterProfiler R package .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GO", "and", "KEGG", "pathways", "were", "analyzed", "and", "visualized", ...
PMC6901583	b After 19 days, mice were sacrificed, and tumor weights were examined in the two groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "After", "19", "days", ",", ...
PMC9429973	Mice were sacrificed 2 or 14 days after the last injection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mice", "were", "sacrificed", "2", "or", "14", "days", "after", "the", "last", "...
PMC11596967	This diversity makes them essential resources for discovering and engineering novel AOPs that effectively combat oxidative stress and mitigate related cellular damage .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "dive...
PMC9429973	Increased Hb was associated with decreased risk of respiratory-related events.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Increased", "Hb", "was", "associated", "with", "decreased", "risk", "of", "respiratory-related", ...
PMC10988555	Future studies using inhibitors for each specific human cell-based transporter will provide a very nice and detailed study for a subsequent paper, namely addressing the internalization of complexes 2-4 in cells as well as additional in vivo targets using proteomic studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11725127	P < 0.05, P < 0.01, P < 0.001, P < 0.0001 ns: no significance versus control group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "<", ...
PMC11025866	Several hypotheses for their mechanisms are based on effects of the drugs on ion channels, GABA and glutamate neurotransmission, and cells signaling pathways .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11802929	Our laboratories have recently reported on the feasibility of these libraries to capture and characterize both viral antigen-specific and (tumor-associated) neoantigen-specific T cell populations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11544122	c GPCR endocytosis was examined in the β-arr1/2 DKO HEK293 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "c", "GPCR", "endocytosis", "was", "examined", "in", "the", "β-arr1/2", ...
PMC9581083	A systematic analysis of the efficacies and benefits of TCM for the treatment of COVID-19 was performed, and the mechanisms underlying such treatment are summarized.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10125312	Studying PPTT in an in vitro setting allows for more accurate control of the chemical and physical environment, including more efficient exploration of the parameter space.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7961460	In addition, the whole metabolites produced by cancer cells are today recognized as strategic players in cancer development .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "the", ...
PMC11361748	Though absent from healthy interfollicular epidermis, K6A-C, K16, and K17 are rapidly induced after injury and many other stresses to the skin , in chronic diseases such as PSOR , AD , acne , and in multiple types of carcinomas .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11264242	Consistently, we found that PP2 alone does not have potent anti-synovial sarcoma activity (Supplementary Figure S14A, D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consistently", ",", ...
PMC6133382	The plates were examined daily, and wells with more than a single colony were discarded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "plates", "were", "examined", "daily", ",", ...
PMC11673128	Samples were analyzed using Attune™ NxT Flow Cytometer (Thermo Fisher) and data were interpreted using FCS Express™ version 7 (De Novo Software, Pasadena, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11568601	Images were recorded via a microscope (Olympus Corporation, Tokyo, Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "were", "recorded", "via", "a", "microscope", "(", "Oly...
PMC11765879	To the best of our knowledge, this is the first study investigating the cytotoxic potential of methanolic leaf extract of ZSC against HER2-positive breast cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11731161	As illustrated in Fig. 4C, D, the downregulation of USP7 in MM cells resulted in a significant decrease in XPO1 protein levels, while XPO1 mRNA levels remained largely unchanged.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10170482	These data taken together indicate that culturing of liver tumor cells in soft 3D CS leads to specific metabolic rewiring of cells toward lowering mitochondria activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11538390	The r values were estimated from high-coverage whole-genome sequences of 3775 Finns.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "r", "values", "were", "estimated", "from", "high-coverage", "whole-genome", ...
PMC11765678	ER has been shown to bind to P-gp and has been shown to act as a weak inhibitor/substrate for the protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ER", "has", "been...
PMC11752767	The multi-mechanisms of tumor escape as well as the immunosuppressive TME in turn handicap the clinical translational application.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "multi-mechanisms", "of", "tumor", ...
PMC9844987	The raw dispersion of each CAGE tag cluster was calculated using the squared coefficient of variation (CV) of TPM-normalized promoter (or decomposed promoter) expression across the LCL panel and subsequently log10-transformed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11755467	The screen was developed on a Typhoon FLA 7000 imager and bands were densitometrically quantified using ImageJ .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "screen", "was", "developed", "on", "...
PMC9429973	Two studies validated the feasibility of the KB prediction in AML patients (pts) consolidated with chemotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "studies", "validated", "the", "...
PMC9672323	Moreover, no significant difference was observed between TGF-β levels in treated compared to non-treated cells (Fig. 9(a–f), Tab@@les S(19–24)s).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11768281	Articles deemed irrelevant to the scope of this review were excluded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Articles", "deemed", "irrelevant", "to", "the", "scope", "of", "this", "review", "wer...
PMC11394112	Notably, the NSG-IL6 mouse spleens at week 4 were dominated by the U2932-Luc cells.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Notably", ",", "the", "NSG-IL6", "mouse", "sple...
PMC11298021	The statistical data from the cell cycle assay which indicated that compared with the control group, rapamycin group significantly induced G1/sub G1 arrest and reduced S phase entry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11001582	n = 5 mice per genotype, one-way ANOVA, Bonferroni’s multiple comparison.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "5", "mice", "per", "genotype", ",", "one-way", "...
PMC11546117	The use of primary human mammary epithelial cells (hMECs) to study the transfer of medicines into human milk has first been described by Kimura et al. (2006), where a tight monolayer was obtained after three trypsin treatments where the cells that remained attached (about 20%) were allowed to continue growing on the sa...	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11732635	His weight has decreased by 15 kg since the onset of disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "His", "weight", "has", "decreased", "by", "15", "kg", "since", "the", "ons...
PMC11420784	Intracellular UPEC traffics, together with ferritin-bound iron, into the autophagosome to form QIRs .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Intracellular", "UPEC", "traffics", ",", "together", "with", ...
PMC11707577	9,10‐Anthracenediyl‐bis(methylene) dimalonic acid (ABMDMA) reacts with singlet oxygen to give an endoperoxide.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "9,10‐Anthracenediyl‐bis(methylene", ")", "dimalonic", "acid", "(", ...
PMC11476106	Both cytospin and HGs section samples were stained with H&E and immunostained with anti-VN rabbit monoclonal antibody (EP873Y, Clone; ab45139, Abcam, Cambridge, MA, USA) diluted at 1:100, using OptiView Amplification Kit (Ventana Medical Systems Inc., Tucson, AE, USA) in the BenchMark XT automated slide staining system...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11380329	A one-way analysis of variance (ANOVA) followed by post hoc Tukey’s multiple comparison test was used to analyse multiple comparisons, and the differences were considered significant at p < 0.05.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806182	Gene co-expression analysis was conducted using weighted gene co-expression network analysis (WGCNA) to identify gene modules associated with miR-424 and miR-330 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gene", ...
PMC10047551	Moreover, genome stability is supported by a CpG-methylated state, and, accordingly, global hypo-methylation is a hallmark of genome instability associated with carcinogenesis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	It is thought that this relapse is caused by chemoresistance of leukaemic stem cells (LSC) due to their quiescent state.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", ...
PMC9429973	We also frequently isolate PBMCs/BMMCs, extract DNA and perform histopathology on a global scale for clinical trial purposes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "frequently", "isola...
PMC11719944	These cells are associated with a wide range of autoimmune diseases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "cells", "are", "associated", "with", "a", "wide", "range", "of", "autoimmune...
PMC9429973	42 patients had a raised LDH level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "42", "patients", "had", "a", "raised", "LDH", "level", "." ] } ]
PMC9545474	However, concomitantly, the studies we carried out on such complexes led us to identify issues which impair the full translation of their in vitro promises into in vivo lead molecules: lack of aqueous‐solubility and issues in formulating the compounds for injections into mice were found to be the most limiting factors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8164677	Increased replication stress and resulting instability at genomic level may induce disruption of DNA-damaging response resulting in tumor survival and dependence on checkpoint controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10958426	The sequence data have been deposited in the Genome Sequence Archive in BIG Data Center under accession number HRA004167 and HRA000086.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "sequence", ...
PMC11138140	We verified the accuracy of segmentation for each tracked cell in each imaging frame.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "verified", "the", "accuracy", "of", "segmentation", "for", ...
PMC11317131	Lowering the copy number of the AP and CP reduces the number of available plasmids for recombination and provides a third method for increasing stringency.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11767725	These cytokines, produced by hypertrophic adipocytes, immune cells, and the liver, directly influence keratinocyte gene expression by activating intracellular signaling pathways, including the NF-κB- and mitogen-activated protein kinase (MAPK) cascades .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2944824	Tightly controlled apoptotic mechanisms are essential for the correct pruning and formation of synaptic connections during development ; it is thought that these already active death pathways may be responsible for the increased vulnerability of the immature brain to insults .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9587298	Among the phenolic compounds tested, gallic, vanillic, ferulic and chlorogenic acids (Fernandez-Gomez et al., 2015, Silván et al., 2011, Wu et al., 2010), luteolin, rutin, and quercetin (Li et al., 2014, Wu and Yen, 2005), have shown to be effective.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5600151

As one example of this studies, Al-Jamal and co-workers investigated the potential of these dendrimers as DOX carriers .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "one", "example", "of", ...

PMC8414691

Remarkably, SRCAP depletion perturbs both mitosis and cytokinesis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Remarkably", ",", "SRCAP", "depletion", "perturbs", "both", "mitosis", "and", "cytokinesis", "." ] } ...

PMC11240448

Because our own experimental verification was beyond the scope of this work, we computationally demonstrated robustness of cSTAR predictions and reported clinical and biochemical data that support them.

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PMC11748335

B The heatmap shows the top 20 LOLA terms most significantly enriched in peaks within short LOCKs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "The", "heatmap", "shows", "the", "top"...

PMC11750161

Interestingly, our results in the presented study are no activity, in contrast to previously reported data for equine LH/CGR-t656 (Byambaragchaa et al., 2022b), equine FSHR-t641 (Seong et al., 2020), and eel FSHR-t614 (Kim et al., 2018), showing that agonist-induced receptors are not completely impaired in the cAMP res...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11673128

Therefore, the interplay between CD47 and CALR underscores their integral roles in modulating immune responses and presents promising avenues for therapeutic strategies, which should be oriented to selectively upregulate CALR and quench CD47 signaling on cancer cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10788478

It is also possible that LGR6 expression is a prognostic marker for lung adenocarcinomas without EGFR mutations.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "also", "possible", "that", "LGR...

PMC11472569

ABCG2 is highly expressed in the placenta, blood-brain barrier, liver, and intestine, and is notably prevalent in various stem cells, including hematopoietic stem cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11659921

Furthermore, we validated the model with the GSE14764 dataset, and the results were consistent with those obtained from the TCGA‐BLCA dataset (Figure 5F–H).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11697189

Negative correlation with risk score.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Negative", "correlation", "with", "risk", "score", "." ] } ]

PMC9429973

Until now, little information exists on the genomic analysis of LCH with thyroid gland involvement with or without coexisting papillary thyroid carcinoma.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Until",...

PMC10877303

Shahriar Zaman: Writing – review & editing, Resources, Project administration.

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PMC10926885

In addition, we used the TISMO database to examine NDE1 expression levels in cell lines that received different treatments and found that after IFNg treatment, The expression levels of NDE1 in B16_SSG33589424, CT26_RTM28723893 and EMT6_XW33589424 cohorts were significantly lower than those in other treatment groups and...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10565698

P < 0.05, **: P < 0.01, ***: P < 0.001.

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PMC11012012

SLAMF2/CD48, SLAMF8/CD353, and SLAMF9/CD84-H1 can be designated as atypical SLAMF receptors due to differences in their cytoplasmic domains in comparison with the other SLAMF receptors.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11388384

Quantification of signaling gradients formed in the presence of Latrunculin A. Hedgehog (HH) family morphogens are at the forefront of this debate partly because of their lipophilic nature.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11742864

Currently, although surgery is still the first and standard choice for patients with NSCLC, less than 30% of patients receive this treatment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC9429973

Patients with severe congenital neutropenia (SCN) were excluded.

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PMC11471176

Chromogen Solution A and B were added to each well, gently mixed, and incubated at 37 °C for 15 min in the absence of light to avoid sample exposure.

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PMC9429973

E. A. Martino, C. Conticello, E. Zamagni, V. Pavone, S. Palmieri, M. Musso, P. Tacchetti, A. Mele, L. Catlano, E. Vigna, A. Bruzzese, F. Mendicino, C. Botta, D. Vincelli, G. Farina, M. Barone, C. Cangialosi, K. Mancuso, I. Rizziello, S. Rocchi, A. P. Falcone, G. Mele, G. Reddiconto, B. Garibaldi, E. Iaccino, G. Tripepi...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11679892

The increase in absorbance observed spectrophotometrically is directly proportional to the oxidant molecules in the sample .

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PMC11412752

This indicates that STING exerts an antibacterial effect in HepG2 cells.

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PMC11055510

In previous studies, miR-135a-3p was found to be down-regulated in OC patients and tissues and thus it could be considered a tumor suppressor, biomarker, and nucleic acid therapeutic agent in OC (Duan et al., 2018; Fukagawa et al., 2017).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9954564

Sequencing libraries were prepared according to the manufacturer’s instructions using a customized Haloplex Target Enrichment System (Agilent Technologies, Inc., Santa Clara, CA, USA) protocol.

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PMC11700165

The PH-domain plays a key role in activating TFKs.

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PMC11588085

Scheme of XIST KD in ovarian cancer cell line using CRISPRi technology. (

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PMC11489275

Lymphocyte count is a cheap-cost, widely available, easy-to-obtain marker of inflammation, which makes it more convenient for clinical use.

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PMC11629143

RT‐qPCR experiments were repeated using cell pools from three biological repeats.

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PMC7757104

Notably, OPNc cells exhibited increased sensitivity to CDDP compared with that in the control cells, which may be associated with CDDP-induced OPNc downregulation.

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PMC11549062

Overall, these results suggest that the accumulation of PDGFR‐β is associated with plaque apoptosis, which potentially leads to carotid plaque vulnerability.

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PMC11180402

These results demonstrate that SOX2 downregulation contributes to the ISO-mediated inhibition of BMIBC invasion and anchorage-independent growth in 5637 cells.

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PMC5025404

Moreover, all clones grew slowly (doubling time 40–50 h), and the best one, #30, reached the maximum cell density at 12.3 × 10 cells/mL. As a result, fed-batch in shaker flasks gave the effective productivity of only 0.4 g/L (this value indicates the yield after the first purification step).

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PMC11683240

The absorbance was measured using a plate reader at 490 nm.

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PMC11791478

Additional characterizations of 25A3 have been reported (16).

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PMC9429973

Aims: The primary objectives of this multicenter, open-label, phase 1, dose-escalation and dose-expansion study were to evaluate the safety and tolerability of escalating doses of CC-95251 + ritux and to define the maximum tolerated dose (MTD) and/or recommended phase 2 dose for the combination in patients (pts) with C...

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PMC11588085

It has been proposed that XIST lncRNA can be used as a biomarker for treatment and prognostic marker in breast and testicular cancer (20, 26).

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PMC11397654

Preliminary cytotoxicity assays performed on six cancer cell lines (A549, SKOV3, SW1990, Hela, Raji, MDA-MB-231) indicated that the larger macrocycles, i.e., the calixarene and calixarene derivatives, were generally inactive, likely due to their inability to permeate the cell membrane.

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PMC11657744

After washing, membranes were incubated with secondary antibodies for 3 h. Signal detection was performed using a chemiluminescent reagent (Millipore).

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PMC11791478

The safety profile was further validated in nonhuman primate studies, in which treatment with XB002 did not impact clotting times or cause bleeding, supporting its potential for safe clinical use.

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PMC11607764

To explore the associations between PTBP1 and immune cell infiltration, we employed TIMER2.0, a useful resource for comprehensive analysis of tumor-infiltrating immune cells.

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PMC9429973

L. E. Roeker, A. R. Mato, J. R. Brown, C. C. Coombs, N. N. Shah, W. G. Wierda, M. R. Patel, K. L. Lewis, M. Balbas, J. Zhao, N. C. Ku, J. F. Kherani, D. E. Tsai, B. Nair, C. Y. Cheah Memorial Sloan Kettering Cancer Center, New York; Dana-Farber Cancer Institute and Harvard Medical School, Boston; University of North Ca...

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PMC6024716

The mass spectra were acquired using a Turbo Spray Ionization of 2500 V in positive ion mode, and multiple reaction monitoring (MRM).

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PMC9429973

Systemic chronic inflammation, thrombocytosis, abnormal platelet functions, proinflammatory cytokines, hypertension, obesity, diabetes, and dyslipidemia contribute to the elevated risk of thromboembolic events.

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PMC11481779

In the case of the higher blur, with σ = 3, we are getting a much more augmented matrix - and the FID score rises to 61.5.

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PMC6160470

Pellets were lysed with RIPA buffer supplemented with complete protease inhibitor (Sigma-Aldrich, USA) and subsequently sonicated using Bioruptor sonicator (Diagenode).

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PMC11186948

Patient #249 was clinically and phenotypically evaluated by an expert clinical geneticist (DM) who proposed a clinical diagnosis of RSTS.

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PMC9027909

They showed a significant higher protease activity of Blastocystis sp., ST3 isolated from symptomatic subjects compared to those isolated from asymptomatic individuals .

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PMC10988555

The culture media was recovered to a new tube (supernatant fraction) and cells were detached from the T-flask with 2 mL of TripLE Express (TE) (Gibco by life technologies) and centrifuged at 750 × g for 5 min.

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PMC8806312

GO and KEGG pathways were analyzed and visualized by the clusterProfiler R package .

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PMC6901583

b After 19 days, mice were sacrificed, and tumor weights were examined in the two groups.

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PMC9429973

Mice were sacrificed 2 or 14 days after the last injection.

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PMC11596967

This diversity makes them essential resources for discovering and engineering novel AOPs that effectively combat oxidative stress and mitigate related cellular damage .

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PMC9429973

Increased Hb was associated with decreased risk of respiratory-related events.

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PMC10988555

Future studies using inhibitors for each specific human cell-based transporter will provide a very nice and detailed study for a subsequent paper, namely addressing the internalization of complexes 2-4 in cells as well as additional in vivo targets using proteomic studies.

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PMC11725127

P < 0.05, P < 0.01, P < 0.001, P < 0.0001 ns: no significance versus control group.

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PMC11025866

Several hypotheses for their mechanisms are based on effects of the drugs on ion channels, GABA and glutamate neurotransmission, and cells signaling pathways .

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PMC11802929

Our laboratories have recently reported on the feasibility of these libraries to capture and characterize both viral antigen-specific and (tumor-associated) neoantigen-specific T cell populations.

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PMC11544122

c GPCR endocytosis was examined in the β-arr1/2 DKO HEK293 cell line.

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PMC9581083

A systematic analysis of the efficacies and benefits of TCM for the treatment of COVID-19 was performed, and the mechanisms underlying such treatment are summarized.

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PMC10125312

Studying PPTT in an in vitro setting allows for more accurate control of the chemical and physical environment, including more efficient exploration of the parameter space.

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PMC7961460

In addition, the whole metabolites produced by cancer cells are today recognized as strategic players in cancer development .

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PMC11361748

Though absent from healthy interfollicular epidermis, K6A-C, K16, and K17 are rapidly induced after injury and many other stresses to the skin , in chronic diseases such as PSOR , AD , acne , and in multiple types of carcinomas .

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PMC11264242

Consistently, we found that PP2 alone does not have potent anti-synovial sarcoma activity (Supplementary Figure S14A, D).

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PMC6133382

The plates were examined daily, and wells with more than a single colony were discarded.

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PMC11673128

Samples were analyzed using Attune™ NxT Flow Cytometer (Thermo Fisher) and data were interpreted using FCS Express™ version 7 (De Novo Software, Pasadena, CA, USA).

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PMC11568601

Images were recorded via a microscope (Olympus Corporation, Tokyo, Japan).

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PMC11765879

To the best of our knowledge, this is the first study investigating the cytotoxic potential of methanolic leaf extract of ZSC against HER2-positive breast cancer.

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PMC11731161

As illustrated in Fig. 4C, D, the downregulation of USP7 in MM cells resulted in a significant decrease in XPO1 protein levels, while XPO1 mRNA levels remained largely unchanged.

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PMC10170482

These data taken together indicate that culturing of liver tumor cells in soft 3D CS leads to specific metabolic rewiring of cells toward lowering mitochondria activity.

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PMC11538390

The r values were estimated from high-coverage whole-genome sequences of 3775 Finns.

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PMC11765678

ER has been shown to bind to P-gp and has been shown to act as a weak inhibitor/substrate for the protein.

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PMC11752767

The multi-mechanisms of tumor escape as well as the immunosuppressive TME in turn handicap the clinical translational application.

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PMC9844987

The raw dispersion of each CAGE tag cluster was calculated using the squared coefficient of variation (CV) of TPM-normalized promoter (or decomposed promoter) expression across the LCL panel and subsequently log10-transformed.

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PMC11755467

The screen was developed on a Typhoon FLA 7000 imager and bands were densitometrically quantified using ImageJ .

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PMC9429973

Two studies validated the feasibility of the KB prediction in AML patients (pts) consolidated with chemotherapy.

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PMC9672323

Moreover, no significant difference was observed between TGF-β levels in treated compared to non-treated cells (Fig. 9(a–f), Tab@@les S(19–24)s).

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PMC11768281

Articles deemed irrelevant to the scope of this review were excluded.

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PMC11394112

Notably, the NSG-IL6 mouse spleens at week 4 were dominated by the U2932-Luc cells.

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PMC11298021

The statistical data from the cell cycle assay which indicated that compared with the control group, rapamycin group significantly induced G1/sub G1 arrest and reduced S phase entry.

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PMC11001582

n = 5 mice per genotype, one-way ANOVA, Bonferroni’s multiple comparison.

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PMC11546117

The use of primary human mammary epithelial cells (hMECs) to study the transfer of medicines into human milk has first been described by Kimura et al. (2006), where a tight monolayer was obtained after three trypsin treatments where the cells that remained attached (about 20%) were allowed to continue growing on the sa...

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PMC11732635

His weight has decreased by 15 kg since the onset of disease.

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PMC11420784

Intracellular UPEC traffics, together with ferritin-bound iron, into the autophagosome to form QIRs .

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PMC11707577

9,10‐Anthracenediyl‐bis(methylene) dimalonic acid (ABMDMA) reacts with singlet oxygen to give an endoperoxide.

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PMC11476106

Both cytospin and HGs section samples were stained with H&E and immunostained with anti-VN rabbit monoclonal antibody (EP873Y, Clone; ab45139, Abcam, Cambridge, MA, USA) diluted at 1:100, using OptiView Amplification Kit (Ventana Medical Systems Inc., Tucson, AE, USA) in the BenchMark XT automated slide staining system...

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PMC11380329

A one-way analysis of variance (ANOVA) followed by post hoc Tukey’s multiple comparison test was used to analyse multiple comparisons, and the differences were considered significant at p < 0.05.

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PMC11806182

Gene co-expression analysis was conducted using weighted gene co-expression network analysis (WGCNA) to identify gene modules associated with miR-424 and miR-330 .

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PMC10047551

Moreover, genome stability is supported by a CpG-methylated state, and, accordingly, global hypo-methylation is a hallmark of genome instability associated with carcinogenesis .

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PMC9429973

It is thought that this relapse is caused by chemoresistance of leukaemic stem cells (LSC) due to their quiescent state.

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PMC9429973

We also frequently isolate PBMCs/BMMCs, extract DNA and perform histopathology on a global scale for clinical trial purposes.

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PMC11719944

These cells are associated with a wide range of autoimmune diseases.

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PMC9429973

42 patients had a raised LDH level.

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PMC9545474

However, concomitantly, the studies we carried out on such complexes led us to identify issues which impair the full translation of their in vitro promises into in vivo lead molecules: lack of aqueous‐solubility and issues in formulating the compounds for injections into mice were found to be the most limiting factors.

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PMC8164677

Increased replication stress and resulting instability at genomic level may induce disruption of DNA-damaging response resulting in tumor survival and dependence on checkpoint controls.

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PMC10958426

The sequence data have been deposited in the Genome Sequence Archive in BIG Data Center under accession number HRA004167 and HRA000086.

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PMC11138140

We verified the accuracy of segmentation for each tracked cell in each imaging frame.

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PMC11317131

Lowering the copy number of the AP and CP reduces the number of available plasmids for recombination and provides a third method for increasing stringency.

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PMC11767725

These cytokines, produced by hypertrophic adipocytes, immune cells, and the liver, directly influence keratinocyte gene expression by activating intracellular signaling pathways, including the NF-κB- and mitogen-activated protein kinase (MAPK) cascades .

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PMC2944824

Tightly controlled apoptotic mechanisms are essential for the correct pruning and formation of synaptic connections during development ; it is thought that these already active death pathways may be responsible for the increased vulnerability of the immature brain to insults .

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PMC9587298

Among the phenolic compounds tested, gallic, vanillic, ferulic and chlorogenic acids (Fernandez-Gomez et al., 2015, Silván et al., 2011, Wu et al., 2010), luteolin, rutin, and quercetin (Li et al., 2014, Wu and Yen, 2005), have shown to be effective.

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