OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC10538569	The average values ± standard deviation (SD) are shown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "average", "values", "±", "standard", "deviation", "(", "SD", ")", "are", ...
PMC11708541	The continuous production of inflammatory agents can lead to tissue and DNA damage by stimulating cell proliferation to cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "continuous", "production", ...
PMC11585994	After treatment, three mice from each group were randomly selected for histological analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "treatment", ",", "three", "mice", "from", "each", "grou...
PMC9429973	Mean (SD) age was 61.6 (17.0) years; 14 pts (56%) were female and 23 (92%) were White.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6889484	Multiple rounds of infection were monitored up to 42 days post-infection. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Multiple", "rounds", "of", "infection", "were", "monitored", "up", "to", "42", ...
PMC11545737	Central to H. pylori infection is the production of urease, which catalyzes the production of ammonia and carbonic acid from urea, neutralizing gastric acidity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11765988	Higher levels of miR-146a and miR-150, two of the most commonly studied miRNAs, are found in sarcoidosis patients compared to controls and are associated with a more severe radiologic and functional phenotype .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Due to the continuous treatment paradigm, the cumulative dose of corticosteroids in patients is substantial.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Due", "to", "the", "continuous", "treatment", "paradig...
PMC10976516	While immune cells were once believed to be nothing more than primary, albeit not efficient, viral transporters to tumor locations, more recent research has concentrated on developing a synergy between the virus and immune cells to increase the anticancer effects of both entities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11240571	For example, high levels of exosomal PD-L1 were correlated with advanced tumor stage, larger tumor size (>2.5 cm), lymph node metastasis, and distant metastasis in patients with NSCLC .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11684297	Post incubation, we found that the nanoflowers and the undegraded IA were settled at the bottom of the tube, and the supernatant contained the degraded amyloids.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8469018	The obtained cell pellets were resuspended in 0.25 mL of DAPI and analyzed immediately using 8-chamber NC-Slides A8™ and the Mitochondrial Potential Assay protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11055323	Scale bars, 5 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ",", "5", "μm", "." ] } ]
PMC10849234	First, a cell-line expressing a dCas9-KRAB fusion was created.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "First", ",", "a", "cell-line", "expressing", "a", "dCas9-KRAB", "fusion", "was", "created", ...
PMC11451940	These metals have been shown to possess a broad spectrum of activities and relatively low toxicity and are suggested to be able to overcome the resistance to cisplatin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11449273	The number of migrated or invaded cells was quantitated from five random fields using NIH ImageJ Cell Counter software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "number", "of", "migrated",...
PMC11769516	In addition, honey supplementation improved antioxidant defense systems and LPO in other tissues of animals that received both honey and AFs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "additi...
PMC11473750	Primers were synthesised by Sigma-Aldrich (Australia).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Primers", "were", "synthesised", "by", "Sigma-Aldrich", "(", "Australia", ")", "." ] } ]
PMC11803149	We subcutaneously injected B16-OVA tumor cells into young or aged C57BL/6 mice.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "We", "subcutaneously", "injected", "B16-OVA", "tumor", "cells", "into", ...
PMC9429973	Methods: We performed whole exome sequencing, deep clinical phenotyping and immunophenotyping in a patient with ES and his clinically asymptomatic brother.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods...
PMC11627133	Scale bars, 10 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ",", "10", "μm", "." ] } ]
PMC11188874	Our findings offer solutions to both problems because proteasome activation amplifies neoantigen and tumor-specific antigen presentation as actionable targets for endogenous and engineered T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11676169	Immune complexes were analyzed by SDS-PAGE and immunoblot.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immune", "complexes", "were", "analyzed", "by", "SDS-PAGE", "and", "immunoblot", "." ] } ]
PMC7433824	As will be outlined below, some of our findings are parallel to these concepts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "will", "be", "outlined", "below", ",", "some", ...
PMC10604092	This activates a melanocortin 4 receptor-dependent anorectic pathway that suppresses appetite .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "activates", "a", "melanocortin", "4", "receptor-dependent", "anorectic", "pathway", ...
PMC11411004	HDACs regulate a variety of cellular processes in eukaryotes, including apoptosis (Fulda 2008, 2012), cell cycle arrest (Gu et al. 2023; Li et al. 2012), cellular differentiation (Nalawansha et al. 2017), anti-angiogenesis (Deng et al. 2020), and autophagy (Bondarev et al. 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The mean hospital charges were $36048 (SD $58044).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mean", "hospital", "charges", "were", "$", "36048", "(", "SD", "$",...
PMC11665555	These results extended to our orthotopic tumor model where GR-OXCT1KO cells were less tumorigenic compared with the parental and 5637GR counterparts (Figures 6 and 7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", ...
PMC11441402	However, for the two adherent cell lines this assay did not accurately measure the number of viable adherent cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "for", ...
PMC9910796	As shown in Fig 7B and S9 Fig, immunofluorescence analysis showed that pp220NT-V5 preferentially displayed a cytoplasmic vesicular-like pattern made up of discrete, ring-shaped structures of heterogeneous size, as occurred with the full-length protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7840816	As indicated in Figure 1A, the expression of SOX9 mRNA was significantly increased in PTC samples when compared with those in normal thyroid specimens.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Image: Summary/Conclusion: Treatment-naive and switched pts with PNH treated with crovalimab in the COMPOSER trial maintained disease control over long-term follow-up.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image",...
PMC5916734	Hence, the activity of soluble human PACE/furin in the generated cell population was sufficiently high to ensure an almost complete propeptide cleavage; however, the degree of γ-carboxylation in most cells was insufficient for a proper formation of the Gla domain of FIX.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594641	Discrepancies in the evidence on the Rab27A requirement in sEV generation from melanoma cells are unlikely due to the methodology used to silence it.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10705095	Its primary function is to transport oxygen from the lungs to various tissues in the body .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Its", "primary", "function", "is", "to", "transport", ...
PMC11544122	All MST experiments were carried out in MST buffer (50 mM MOPS (3-(N-morpholino) propanesulfonic acid, pH 7, 100 mM NaCl).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Although not sufficiently mature to estimate risks of SCD-related severe heart, kidney and liver failure, there is already significant morbidity associated with pulmonary hypertension, cerebrovascular disease, and avascular necrosis in the HbSS genotype despite standard therapy, and this suggests the need to intensify ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Even if adherence to ibrutinib was reported to be high in particularly monitored clinical trial settings, the rate of ibrutinib adherence and persistence in real-world populations has hardly been investigated so far.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8409415	RMG‐1 was cultured in Ham's F12 medium (Thermo Fisher Scientific Inc.) containing 10% fetal bovine serum (FBS), 100 U/mL penicillin, and 100 µg/mL streptomycin (Nacalai Tesque).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10940855	Forty thousand cells were placed in 96-well U-bottom tissue culture plates containing 200 mL of RPMI media supplemented with 1% FBS and 8 mg/mL of polybrene (Sigma Aldrich, TR-1003-G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8996378	Diterpenoids (C20), one of the largest groups of natural products, are derived from four C5 isoprene units.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Diterpenoids", "(", ...
PMC10671321	Since then, over 50 pathogenic variants (missense, deletion or nonsense) have been identified in COLQ, and these are spread all along the gene, affecting the three major domains described above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11012012	In CLL, SAP expression could not be detected at the mRNA level .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "CLL", ",", "SAP", "expression", "could", "not", "be", "detected...
PMC11640115	The group with lymphocyte counts ≥1250/μL had a significantly improved ORR compared with the group with lymphocyte counts <1250/μL (<1250/μL: 18.6%, ≥1250/μL: 56.3%, p = 0.0082) (Figure 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11774747	The safety of CAR-VST has been a central focus in clinical research, with early-phase trials such as NCT00840853 showing a favorable safety profile for donor-derived CD19.CAR-VST, with no reported infusion-related toxicities or cases of GvHD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11629143	We suggest that promoter escape by Pol II into active transcript elongation may be a rate‐limiting step in transgene expression in this context, which can be alleviated by increasing the acetylation of histones at the CMV promoter.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740573	Control refers to cells which received no bacteria and calcitriol over the culture period.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Control", "refers", "to", "cells", "which", "received", "no", "b...
PMC11127909	These results suggested that EFHD1 could inhibit mPTP opening to support OS cell survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "suggested", "that", "EFHD1", "could", "inhibit", ...
PMC10154097	All protocols were explained to the patients and were approved by the Ethics Committee of our hospital.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "protocols", "were", "explained", "to", ...
PMC11106977	Interestingly, researchers have observed changes in intracellular O-GlcNAcylation levels during the differentiation of BMSCs into adipogenic, chondrogenic, and osteogenic cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interes...
PMC3730428	These differences between the cell lines may be related to their relative levels of FLIP(L) and FLIP(S) expression, as well as different levels of expression of other components of the TNFR1 signaling pathway (Figure 1a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10196713	As a result, the mitochondrial membrane potential in OVK18cis cells was upregulated by treatment with cisplatin and suppressed by treatment with deferoxamine (Fig. 4B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9516401	According to our protocol, all herbs were weighted and subjected to extraction with 70% ethanol in a Soxhlet apparatus for 72 hr.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11155445	The tetrahedral geometry of Co(ii) and Ni(ii) complexes and square planar geometry of Cu(ii) complexes was confirmed by magnetic susceptibility studies (Fig. 53).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5535901	Using Jurkat T-cells exposed to phorbol-12-myristate-13-acetate (PMA)/ionomycin (calcium ionophore) cocktail, we showed that I3C and DIM pretreatment, at high concentrations, can induce Ca-dependent downstream inflammatory pathways: I3C activates NF-κB and NFAT1 signaling, while DIM, unlike I3C, acting through NF-κB, l...	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: Therefore, in this work, we explored whether presence of GFI1-36N alters DNA repair activity and whether this can be targeted therapeutically.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11509224	Moreover, there is no unified standard for defining the presence and strength of activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "there", "is", "no", "unified", "standard",...
PMC11468365	Many methods have been proposed to design a simulation model that predicts the efficacy of drug combinations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Many", "methods", "have", "been", "proposed", ...
PMC11271278	The H3K27ac HiChIP anchors were then intersected with ±2.5 kb of transcription start sites (NCBI RefSeq gene list downloaded from UCSC browser in 2019) using bedtools to identify promoters and enhancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7039683	We created a double-transgenic embryo, harboring a tdTomato reporter whose expression is driven by the krt4 promoter, and confirmed that tdTomato and GFP expression overlap (Figure 4F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10024132	The standard first-line treatment for ALL patients is chemotherapy, which damages the patient's T cells both quantitatively and qualitatively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "standard", ...
PMC11653168	Several factors could explain this discrepancy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "factors", "could", "explain", "this", "discrepancy", "." ] } ]
PMC10669128	To overcome IM resistance in GIST patients, other drugs have been tested over the years, such as sorafenib, which displays clinical activity against TKI-resistant GISTs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11473750	g Kaplan–Meier curves of Overall Survival probability for patients from the Kocak (n = 476) or SEQC neuroblastoma cohort (n = 498) subdivided by RNF121 mRNA expression and MYCN amplification status (Amplified; MA, Non-amplified; MNA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11437637	Moreover, Tregs and phosphatase and tensin homolog deleted on chromosome ten (PTEN) expression have been proposed as EC predictors , which indicates the potential value of PBLs as non-invasive markers for EC screening, especially when combined with other markers, such as tumor markers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9917080	Selenium nanoparticles (SeNPs) also have a high anticancer efficacy in glioblastomas, but are less selective, since SeSo in cortical astrocytes causes a more pronounced activation of the cytoprotective pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9739791	The second approach is to conjugate a photoabsorber and a Pt(IV) complex in one molecule, which can overcome such drawbacks of the combinational approach as different bioavailability and metabolism of drugs used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11476222	The optimal conditions were determined to be a flow rate of 0.2 mL/min and a 25 min run time.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "optimal", "conditions", "w...
PMC9429973	ORR per IMWG 2016 criteria was the primary endpoint.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ORR", "per", "IMWG", "2016", "criteria", "was", "the", "primary", "endpoint", "." ] } ]
PMC8540611	Optimal delivery concentrations were 100 μg/mL for AuNP13, 25 μg/mL for AuNP14, and 10 μg/mL for AuNP15.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Optimal", "delivery", "concentrations",...
PMC9429973	We identified canonical events, such as TAL1-STIL fusions, TCR rearrangements, and activation by TAL1/LMO1/LMO2 regulatory region indels, but also novel events, such as CD34 specific enhancer duplications downstream of TAL1 and BCL11B enhancer hijacking by LMO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10243817	Then, a Kruskal-Wallis test with a Dunn’s post hoc test for multiple comparisons and the Mann-Whitney U 2-tailed test for binary comparisons were employed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Our results highlight the value of anemia at initial visit in discriminating high SCTC-DI score and predicting 5-year organ damage progression, demonstrating the regular and careful monitoring of these patients may help to improve the prognosis of organ damage in SSc.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697189	Of course, our study has limitations and further multicenter studies and experimental investigations are needed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", "course", ",", "our", "study", "has", "limi...
PMC9164404	Multi-omics analysis, as a powerful tool, has been frequently employed for the mechanism study of a certain therapy at the molecular level, which might be helpful for elucidating the mechanism of platinum drugs and facilitating their clinical application.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11576293	On the other hand, visual inspection of docking poses of compound 22 within the EGFR active site revealed a common binding mode mediated through the S-benzyloxy moiety with Arg 817, which caused the whole molecule to move closer to Lys 721 and stabilized the whole molecule more efficiently than compound 29, as shown in...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6160470	As the slopes of linear trend lines fitted for MAC and DAC compounds are opposite, the best regression fit for all compounds together (MACs and DACs) is polynomial with order 2 (R = 0.3507; Fig. 2e).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11644761	The RNA extraction from SK-N-BE cells was performed using a MagCore Compact Automated Nucleic Acid Extractor (RBC Bioscience, New Taipei, Taiwan, Cat.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11078693	Carefully decant PBS out of the tube to leave 5–10 mL.b.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Carefully", "decant", "PBS", "out", "of", "the", "tube", "to", "leave", "5–10", ...
PMC11578343	Scale bar = 50 µm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "=", "50", "µm", "." ] } ]
PMC11583690	These results indicate that BPMO@DTX enhances the anticancer efficacy in A549 cells compared to both free DTX and MSN@DTX.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "indicate",...
PMC11665584	The identified subtypes corresponded with lymphoid (T cell, Proliferating T cell, and NK cell) and myeloid (Macrophage 1–3, Dendritic 1 & 2, Langerhans, Monocyte, and Neutrophil 1 & 2) immune populations (Figure 4B and Supplemental Figure 7B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6650823	In these Editorials, we highlight in brief reports (of about one hundred words) a number of recently published articles that describe crucial findings, such as the discovery of novel drug targets and mechanisms of action or novel classes of drugs, which may inspire future medicinal chemistry endeavors devoted to addres...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6835428	Consequently, the description of in vivo experiments requires both phases, i.e., all four modules, while in vitro experiments imply the use of just the cellular phase, i.e., the last three modules.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11599565	We extracted from the transcriptome results the neuronal-related genes found enhanced in SKOV3 cells treated with cisplatin for 72 h and depicted the existence or until unknown interconnection of more than 32 different genes related to neuronal processes found upregulated in cisplatin exposured cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11703896	As a result, rapamycin’s efficacy in long-term cancer management is compromised.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "result", ",", "rapamycin", "’s", "efficacy", "in", "long-t...
PMC6034753	β-galactosidase was used as positive control for the Chariot Transfection reagent (Active motif, Rixensart, Belgium).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "β-galactosidase", "was", "used", ...
PMC11011837	Nevertheless, the lower ratios in the Molt-16 cell line could suggest a higher activity in pathways involving the desaturation of fatty acids compared to the other cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11507371	For that reason, this study focused, in particular, on investigating the efficacy of CAP on malignant and non-malignant cells under identical culture conditions, as the non-comparability of the culture media composition was a major drawback of past studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697189	ccRCC patients without clinical information were excluded from analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ccRCC", "patients", "without", "clinical", "information", "were", "excluded", "from", "analysis", "." ]...
PMC8633974	GFP LNP treatment to the cells showed readily detectable GFP expression in both U1 and JLat cell lines affirmed by the shift of population intensities for GFP recorded cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	The median BMI was 25.7 kg/m^2 (23.3–28.3), and 14 patients (15.5%) had BMI>30.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "BMI", "was", ...
PMC11611077	Data points are fit to the Boltzmann function (Eq (4)) and shown by solid lines . (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "points", "are", ...
PMC5574817	Surviving cells cultured in complete medium containing 500 µg/mL of G418 sulfate were selected manually using a pipette tip and transferred into 24-well plates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	To our knowledge, single agent HMA in KMT2Ar ALL has been reported only in one patient.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "our", "knowledge", ",", "single", "ag...
PMC9000591	Remarkably, oxidative stress was proven to be correlated closely with cancer , and numerous reports have discussed this correlation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Remarkably", ",", "oxidative...
PMC11768927	Consequently, these engineered strains retain the ability to replicate selectively in cancer cells while reducing the risk of neurotoxic effects associated with WT VSV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC7342409	Firstly, in this study, only one site of this pathway was detected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Firstly", ",", "in", "this", "study", ",", "only", "one", ...
PMC6379402	We show that an iCell better captures the functional organization of the cell than any of its constituent molecular networks alone (see section What is an iCell).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11472569	For example, siRNA-mediated inhibition of Rab27a reduces EV release and significantly decreases miR-155-induced gemcitabine resistance in pancreatic cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "example", ",", ...

PMC10538569

The average values ± standard deviation (SD) are shown.

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PMC11708541

The continuous production of inflammatory agents can lead to tissue and DNA damage by stimulating cell proliferation to cancer.

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PMC11585994

After treatment, three mice from each group were randomly selected for histological analysis.

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PMC9429973

Mean (SD) age was 61.6 (17.0) years; 14 pts (56%) were female and 23 (92%) were White.

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PMC6889484

Multiple rounds of infection were monitored up to 42 days post-infection. (

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PMC11545737

Central to H. pylori infection is the production of urease, which catalyzes the production of ammonia and carbonic acid from urea, neutralizing gastric acidity.

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PMC11765988

Higher levels of miR-146a and miR-150, two of the most commonly studied miRNAs, are found in sarcoidosis patients compared to controls and are associated with a more severe radiologic and functional phenotype .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Due to the continuous treatment paradigm, the cumulative dose of corticosteroids in patients is substantial.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Due", "to", "the", "continuous", "treatment", "paradig...

PMC10976516

While immune cells were once believed to be nothing more than primary, albeit not efficient, viral transporters to tumor locations, more recent research has concentrated on developing a synergy between the virus and immune cells to increase the anticancer effects of both entities.

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PMC11240571

For example, high levels of exosomal PD-L1 were correlated with advanced tumor stage, larger tumor size (>2.5 cm), lymph node metastasis, and distant metastasis in patients with NSCLC .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11684297

Post incubation, we found that the nanoflowers and the undegraded IA were settled at the bottom of the tube, and the supernatant contained the degraded amyloids.

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PMC8469018

The obtained cell pellets were resuspended in 0.25 mL of DAPI and analyzed immediately using 8-chamber NC-Slides A8™ and the Mitochondrial Potential Assay protocol.

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PMC11055323

Scale bars, 5 μm.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ",", "5", "μm", "." ] } ]

PMC10849234

First, a cell-line expressing a dCas9-KRAB fusion was created.

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PMC11451940

These metals have been shown to possess a broad spectrum of activities and relatively low toxicity and are suggested to be able to overcome the resistance to cisplatin.

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PMC11449273

The number of migrated or invaded cells was quantitated from five random fields using NIH ImageJ Cell Counter software.

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PMC11769516

In addition, honey supplementation improved antioxidant defense systems and LPO in other tissues of animals that received both honey and AFs.

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PMC11473750

Primers were synthesised by Sigma-Aldrich (Australia).

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PMC11803149

We subcutaneously injected B16-OVA tumor cells into young or aged C57BL/6 mice.

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PMC9429973

Methods: We performed whole exome sequencing, deep clinical phenotyping and immunophenotyping in a patient with ES and his clinically asymptomatic brother.

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PMC11627133

Scale bars, 10 μm.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ",", "10", "μm", "." ] } ]

PMC11188874

Our findings offer solutions to both problems because proteasome activation amplifies neoantigen and tumor-specific antigen presentation as actionable targets for endogenous and engineered T cells.

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PMC11676169

Immune complexes were analyzed by SDS-PAGE and immunoblot.

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PMC7433824

As will be outlined below, some of our findings are parallel to these concepts.

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PMC10604092

This activates a melanocortin 4 receptor-dependent anorectic pathway that suppresses appetite .

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PMC11411004

HDACs regulate a variety of cellular processes in eukaryotes, including apoptosis (Fulda 2008, 2012), cell cycle arrest (Gu et al. 2023; Li et al. 2012), cellular differentiation (Nalawansha et al. 2017), anti-angiogenesis (Deng et al. 2020), and autophagy (Bondarev et al. 2021).

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PMC9429973

The mean hospital charges were $36048 (SD $58044).

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PMC11665555

These results extended to our orthotopic tumor model where GR-OXCT1KO cells were less tumorigenic compared with the parental and 5637GR counterparts (Figures 6 and 7).

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PMC11441402

However, for the two adherent cell lines this assay did not accurately measure the number of viable adherent cells.

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PMC9910796

As shown in Fig 7B and S9 Fig, immunofluorescence analysis showed that pp220NT-V5 preferentially displayed a cytoplasmic vesicular-like pattern made up of discrete, ring-shaped structures of heterogeneous size, as occurred with the full-length protein.

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PMC7840816

As indicated in Figure 1A, the expression of SOX9 mRNA was significantly increased in PTC samples when compared with those in normal thyroid specimens.

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PMC9429973

Image: Summary/Conclusion: Treatment-naive and switched pts with PNH treated with crovalimab in the COMPOSER trial maintained disease control over long-term follow-up.

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PMC5916734

Hence, the activity of soluble human PACE/furin in the generated cell population was sufficiently high to ensure an almost complete propeptide cleavage; however, the degree of γ-carboxylation in most cells was insufficient for a proper formation of the Gla domain of FIX.

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PMC11594641

Discrepancies in the evidence on the Rab27A requirement in sEV generation from melanoma cells are unlikely due to the methodology used to silence it.

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PMC10705095

Its primary function is to transport oxygen from the lungs to various tissues in the body .

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PMC11544122

All MST experiments were carried out in MST buffer (50 mM MOPS (3-(N-morpholino) propanesulfonic acid, pH 7, 100 mM NaCl).

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PMC9429973

Although not sufficiently mature to estimate risks of SCD-related severe heart, kidney and liver failure, there is already significant morbidity associated with pulmonary hypertension, cerebrovascular disease, and avascular necrosis in the HbSS genotype despite standard therapy, and this suggests the need to intensify ...

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PMC9429973

Even if adherence to ibrutinib was reported to be high in particularly monitored clinical trial settings, the rate of ibrutinib adherence and persistence in real-world populations has hardly been investigated so far.

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PMC8409415

RMG‐1 was cultured in Ham's F12 medium (Thermo Fisher Scientific Inc.) containing 10% fetal bovine serum (FBS), 100 U/mL penicillin, and 100 µg/mL streptomycin (Nacalai Tesque).

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PMC10940855

Forty thousand cells were placed in 96-well U-bottom tissue culture plates containing 200 mL of RPMI media supplemented with 1% FBS and 8 mg/mL of polybrene (Sigma Aldrich, TR-1003-G).

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PMC8996378

Diterpenoids (C20), one of the largest groups of natural products, are derived from four C5 isoprene units.

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PMC10671321

Since then, over 50 pathogenic variants (missense, deletion or nonsense) have been identified in COLQ, and these are spread all along the gene, affecting the three major domains described above.

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PMC11012012

In CLL, SAP expression could not be detected at the mRNA level .

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PMC11640115

The group with lymphocyte counts ≥1250/μL had a significantly improved ORR compared with the group with lymphocyte counts <1250/μL (<1250/μL: 18.6%, ≥1250/μL: 56.3%, p = 0.0082) (Figure 1).

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PMC11774747

The safety of CAR-VST has been a central focus in clinical research, with early-phase trials such as NCT00840853 showing a favorable safety profile for donor-derived CD19.CAR-VST, with no reported infusion-related toxicities or cases of GvHD.

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PMC11629143

We suggest that promoter escape by Pol II into active transcript elongation may be a rate‐limiting step in transgene expression in this context, which can be alleviated by increasing the acetylation of histones at the CMV promoter.

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PMC11740573

Control refers to cells which received no bacteria and calcitriol over the culture period.

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PMC11127909

These results suggested that EFHD1 could inhibit mPTP opening to support OS cell survival.

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PMC10154097

All protocols were explained to the patients and were approved by the Ethics Committee of our hospital.

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PMC11106977

Interestingly, researchers have observed changes in intracellular O-GlcNAcylation levels during the differentiation of BMSCs into adipogenic, chondrogenic, and osteogenic cells .

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PMC3730428

These differences between the cell lines may be related to their relative levels of FLIP(L) and FLIP(S) expression, as well as different levels of expression of other components of the TNFR1 signaling pathway (Figure 1a).

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PMC10196713

As a result, the mitochondrial membrane potential in OVK18cis cells was upregulated by treatment with cisplatin and suppressed by treatment with deferoxamine (Fig. 4B).

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PMC9516401

According to our protocol, all herbs were weighted and subjected to extraction with 70% ethanol in a Soxhlet apparatus for 72 hr.

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PMC11155445

The tetrahedral geometry of Co(ii) and Ni(ii) complexes and square planar geometry of Cu(ii) complexes was confirmed by magnetic susceptibility studies (Fig. 53).

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PMC5535901

Using Jurkat T-cells exposed to phorbol-12-myristate-13-acetate (PMA)/ionomycin (calcium ionophore) cocktail, we showed that I3C and DIM pretreatment, at high concentrations, can induce Ca-dependent downstream inflammatory pathways: I3C activates NF-κB and NFAT1 signaling, while DIM, unlike I3C, acting through NF-κB, l...

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PMC9429973

Aims: Therefore, in this work, we explored whether presence of GFI1-36N alters DNA repair activity and whether this can be targeted therapeutically.

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PMC11509224

Moreover, there is no unified standard for defining the presence and strength of activity.

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PMC11468365

Many methods have been proposed to design a simulation model that predicts the efficacy of drug combinations.

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PMC11271278

The H3K27ac HiChIP anchors were then intersected with ±2.5 kb of transcription start sites (NCBI RefSeq gene list downloaded from UCSC browser in 2019) using bedtools to identify promoters and enhancers.

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PMC7039683

We created a double-transgenic embryo, harboring a tdTomato reporter whose expression is driven by the krt4 promoter, and confirmed that tdTomato and GFP expression overlap (Figure 4F).

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PMC10024132

The standard first-line treatment for ALL patients is chemotherapy, which damages the patient's T cells both quantitatively and qualitatively.

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PMC11653168

Several factors could explain this discrepancy.

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PMC10669128

To overcome IM resistance in GIST patients, other drugs have been tested over the years, such as sorafenib, which displays clinical activity against TKI-resistant GISTs.

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PMC11473750

g Kaplan–Meier curves of Overall Survival probability for patients from the Kocak (n = 476) or SEQC neuroblastoma cohort (n = 498) subdivided by RNF121 mRNA expression and MYCN amplification status (Amplified; MA, Non-amplified; MNA).

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PMC11437637

Moreover, Tregs and phosphatase and tensin homolog deleted on chromosome ten (PTEN) expression have been proposed as EC predictors , which indicates the potential value of PBLs as non-invasive markers for EC screening, especially when combined with other markers, such as tumor markers.

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PMC9917080

Selenium nanoparticles (SeNPs) also have a high anticancer efficacy in glioblastomas, but are less selective, since SeSo in cortical astrocytes causes a more pronounced activation of the cytoprotective pathways.

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PMC9739791

The second approach is to conjugate a photoabsorber and a Pt(IV) complex in one molecule, which can overcome such drawbacks of the combinational approach as different bioavailability and metabolism of drugs used.

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PMC11476222

The optimal conditions were determined to be a flow rate of 0.2 mL/min and a 25 min run time.

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PMC9429973

ORR per IMWG 2016 criteria was the primary endpoint.

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PMC8540611

Optimal delivery concentrations were 100 μg/mL for AuNP13, 25 μg/mL for AuNP14, and 10 μg/mL for AuNP15.

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PMC9429973

We identified canonical events, such as TAL1-STIL fusions, TCR rearrangements, and activation by TAL1/LMO1/LMO2 regulatory region indels, but also novel events, such as CD34 specific enhancer duplications downstream of TAL1 and BCL11B enhancer hijacking by LMO2.

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PMC10243817

Then, a Kruskal-Wallis test with a Dunn’s post hoc test for multiple comparisons and the Mann-Whitney U 2-tailed test for binary comparisons were employed.

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PMC9429973

Our results highlight the value of anemia at initial visit in discriminating high SCTC-DI score and predicting 5-year organ damage progression, demonstrating the regular and careful monitoring of these patients may help to improve the prognosis of organ damage in SSc.

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PMC11697189

Of course, our study has limitations and further multicenter studies and experimental investigations are needed.

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PMC9164404

Multi-omics analysis, as a powerful tool, has been frequently employed for the mechanism study of a certain therapy at the molecular level, which might be helpful for elucidating the mechanism of platinum drugs and facilitating their clinical application.

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PMC11576293

On the other hand, visual inspection of docking poses of compound 22 within the EGFR active site revealed a common binding mode mediated through the S-benzyloxy moiety with Arg 817, which caused the whole molecule to move closer to Lys 721 and stabilized the whole molecule more efficiently than compound 29, as shown in...

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PMC6160470

As the slopes of linear trend lines fitted for MAC and DAC compounds are opposite, the best regression fit for all compounds together (MACs and DACs) is polynomial with order 2 (R = 0.3507; Fig. 2e).

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PMC11644761

The RNA extraction from SK-N-BE cells was performed using a MagCore Compact Automated Nucleic Acid Extractor (RBC Bioscience, New Taipei, Taiwan, Cat.

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PMC11078693

Carefully decant PBS out of the tube to leave 5–10 mL.b.

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PMC11578343

Scale bar = 50 µm.

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PMC11583690

These results indicate that BPMO@DTX enhances the anticancer efficacy in A549 cells compared to both free DTX and MSN@DTX.

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PMC11665584

The identified subtypes corresponded with lymphoid (T cell, Proliferating T cell, and NK cell) and myeloid (Macrophage 1–3, Dendritic 1 & 2, Langerhans, Monocyte, and Neutrophil 1 & 2) immune populations (Figure 4B and Supplemental Figure 7B).

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PMC6650823

In these Editorials, we highlight in brief reports (of about one hundred words) a number of recently published articles that describe crucial findings, such as the discovery of novel drug targets and mechanisms of action or novel classes of drugs, which may inspire future medicinal chemistry endeavors devoted to addres...

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PMC6835428

Consequently, the description of in vivo experiments requires both phases, i.e., all four modules, while in vitro experiments imply the use of just the cellular phase, i.e., the last three modules.

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PMC11599565

We extracted from the transcriptome results the neuronal-related genes found enhanced in SKOV3 cells treated with cisplatin for 72 h and depicted the existence or until unknown interconnection of more than 32 different genes related to neuronal processes found upregulated in cisplatin exposured cells.

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PMC11703896

As a result, rapamycin’s efficacy in long-term cancer management is compromised.

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PMC6034753

β-galactosidase was used as positive control for the Chariot Transfection reagent (Active motif, Rixensart, Belgium).

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PMC11011837

Nevertheless, the lower ratios in the Molt-16 cell line could suggest a higher activity in pathways involving the desaturation of fatty acids compared to the other cell lines.

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PMC11507371

For that reason, this study focused, in particular, on investigating the efficacy of CAP on malignant and non-malignant cells under identical culture conditions, as the non-comparability of the culture media composition was a major drawback of past studies.

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PMC11697189

ccRCC patients without clinical information were excluded from analysis.

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PMC8633974

GFP LNP treatment to the cells showed readily detectable GFP expression in both U1 and JLat cell lines affirmed by the shift of population intensities for GFP recorded cells. (

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PMC9429973

The median BMI was 25.7 kg/m^2 (23.3–28.3), and 14 patients (15.5%) had BMI>30.

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PMC11611077

Data points are fit to the Boltzmann function (Eq (4)) and shown by solid lines . (

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PMC5574817

Surviving cells cultured in complete medium containing 500 µg/mL of G418 sulfate were selected manually using a pipette tip and transferred into 24-well plates.

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PMC9429973

To our knowledge, single agent HMA in KMT2Ar ALL has been reported only in one patient.

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PMC9000591

Remarkably, oxidative stress was proven to be correlated closely with cancer , and numerous reports have discussed this correlation.

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PMC11768927

Consequently, these engineered strains retain the ability to replicate selectively in cancer cells while reducing the risk of neurotoxic effects associated with WT VSV.

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PMC7342409

Firstly, in this study, only one site of this pathway was detected.

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PMC6379402

We show that an iCell better captures the functional organization of the cell than any of its constituent molecular networks alone (see section What is an iCell).

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PMC11472569

For example, siRNA-mediated inhibition of Rab27a reduces EV release and significantly decreases miR-155-induced gemcitabine resistance in pancreatic cancer cells.

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