OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11718031	In particular, developing rational strategies for using feed/media in suitable combinations is essential for improving fed-batch cell cultures’ process efficiency (Shukla et al. 2017; Rasoul et al. 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711063	Furthermore, the downregulation of E‐cadherin by ZG16B is commensurate with the loss of epithelial characteristics, decreased cell–cell adhesion and cancer progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11792740	Furthermore, T-cell depletion influences the selection of immunotherapeutic strategies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "T-cell", "depletion", "influences", "the", "selection", "of", "immunotherapeutic",...
PMC11468365	represents the set of edges that can be defined by an adjacency matrix .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "represents", "the", "set", "of", "edges", "that", "can", "be", "defin...
PMC11721587	Flag-Fu proteins expressed in Sf9 cells at high MOI were separated into S100 and P100 fractions and then incubated with or without MPA in the presence of Sufu-Ci complexes purified from Sf9 cells for 6 hours, followed centrifugation into S100 and P100 fractions and immunoblot analysis with the indicated antibodies. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6267596	Volcano plots that co-visualize Log2 fold changes and -Log10 P-value for each protein revealed that 8 proteins were significantly up-regulated and 6 proteins were down-regulated in both cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11687167	In summary, STAT molecules promote Th cell differentiation and Treg expansion, while STAT3 phosphorylation and JAK1/2 inhibit PCSK9 expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "summary", "...
PMC10854447	All tested compounds will likely be metabolised by CYP1A2, CYP2C19, and CYP2C9 but will be CYP2D3 inhibitors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "tested", "compounds", "wil...
PMC11683240	This observation suggests that the inhibition of PT may not be reliant on α1AT’s protease inhibitor activity since another protease, antithrombin, does not have inhibitory effects on PT.Figure 3Effect of the serpin proteins α1AT and antithrombin on intoxication of CHO-K1 cells with PT.A–C, PT (10 ng/ml) and α1AT (100 μ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11342785	The IDR fragments were fused with TPPPCORE domain(aa.45–166) into the same pBh4-His-GFP plasmid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "IDR", "fragments", "were", "fused", "with", "TPPPCORE", "...
PMC9429973	IC treatment was daunorubicin 60 mg/m x 3 days, cytarabine 200 mg/m x 7 days, followed by 1-3 additional chemotherapy cycles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11747467	Additionally, normalized mRNA expression data from GSE13507, GSE32894, GSE48075, GSE48276, and single-cell RNA-sequencing data from GSE135337 were retrieved from the Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/gds).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11725127	However, HSP90 inhibitor STA9090 treatment cannot reduce the protein level of KRAS in MM.1S cells, indicating that KRAS is not a substrate of HSP90 (Supporting Information Fig. S3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Median OS for treatment naïve patients at DLBCL-RS diagnosis was not reached.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "OS", "for", "treatment", "naïve", "patients", "at", "DLBCL-RS", "diagn...
PMC11798926	Cells from both cultures were maintained in wild-type rat-derived astrocyte-conditioned neuron maintenance medium (NMM) consisting of 1X Neurobasal (NB) medium (Gibco #21103049), 1X GlutaMAX (Gibco #35050061), and 1X B-27 supplement (Gibco #17504044).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8708099	Osthole reduced the secretion of cytokines (CKs) and the expression level of inflammation-associated genes, which were increased after a histamine treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11661040	Some studies have suggested that activation of the Wnt signaling pathway promotes OS growth(Kansara et al. 2009; Ji et al. 2015; Wen et al. 2021; Liu et al. 2018; Matsuoka et al. 2020), while others have come to the opposite conclusion(Cai et al. 2010).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9512971	Specifically, in PK/pharmacodynamic (PD) simulations, the times above the EC50 of camostat mesilate at doses of 800 mg three times daily and 600 mg qid were 9.8 h and 11.5 h, respectively .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11629192	OFA treatment is safe and effective, easy to administer, and favorable for pediatric anti-NMDAR encephalitis patients who are refractory to the first-line immunotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11783017	This process attracts various immune cells to the tumor microenvironment, transforming "cold" tumors into "hot" tumors [, , ].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11740207	EVs are tiny, membrane-enclosed particles released by cells during various biological activities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EVs", "are", "tiny", ",", "membrane-enclosed", "particles", "released", "by...
PMC9429973	Summary/Conclusion: Use of targeted NGS has dramatically enhanced the efficiency of genotyping for patients with DBA and other inherited bone marrow failure syndromes, allowing for focused management of patients and discovery of novel genotype-phenotype correlations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	One patient did not show CNAs in the analyzed samples (5%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "patient", "did", "not", "show", "CNAs", "in", "the", ...
PMC11607321	Taken together, these diverse examples demonstrate MOSA’s ability to perform both partial and full dataset augmentation validated using various independent datasets and from different laboratories.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11737091	Correlation analysis between DBF4 and immunomodulatory genes Numerous studies have shown that the host immune response determines the progression of cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Correlation", "analysis...
PMC11747949	Treatment did not induce differences in tumor growth (Figure 3A) or metastatic burden in lungs from mice who received CCR2 antagonist compared to vehicle control (Figure 3B,C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680049	In this cultivation variant, the callus tissue exhibited a loose consistency and formed a yellow-brown color (Figure 4d,e. However, it is important to note that the percentage of callus formation did not exceed 10%, and the onset of callusogenesis was only observed between the 30th and 40th days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721277	The aim of this work was the synthesis of natural chlorin that contains a fragment of 6-hydrazinylnicotinic acid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "aim", "of", "this", "work", ...
PMC9739791	The fluorescence quantum yield of prodrug 30, as well as its fluorescence lifetime, was significantly lower than for PPE (Table 11).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11322866	However, the distribution of Lamin B1 in the nuclear envelope was abnormal in RRM2 OE- or GSK126-treated cells, which was characterized by (1) partial absence in the inner nuclear envelope; (2) diffusion within the nucleus or along the periphery of the nuclear envelope without a discrete boundary; and (3) an increase i...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519583	The experimental design is shown in (c), and relative mean intensity of Ki-67 is shown in (d) (n = 6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7334607	Genes with Significant Differential Expression between SP-Resistant and SP-Sensitive Samples Differential gene expression analysis was performed using EBSeq in R, with maxround set to 15 and FDR of 0.05.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11670954	The optimal treatment conditions were determined to be 0.2 mmol/L BA and 5 μg/mL LPS for 24 hours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "optimal", "treatment", "conditions", ...
PMC10706275	This pursuit aims to enhance the advancement of stable cell lines for application in industrial settings.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "pursuit", "aims", "to", "enhance", "the", ...
PMC11089031	The results of the wound healing assay showed that the migration of ccRCC cells was inhibited when ZNF692 was knocked down, while the migration of ccRCC cells was promoted when ZNF692 was overexpressed (Fig. 3H–J).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7887261	Genetic ancestry analysis of TCGA patients shows the vast majority of subjects with “unknown” race were primarily genetic European ancestry (i.e., 90% TCGA-LCs were genetically Europeans). #	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637276	Collagen I dishes were labelled with either 300 μl of 10 μg/ml NHS-fluorescein, 5 μg/ml Alexa Fluor 555 NHS ester, or 20 μg/ml pHrodo iFL red.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11224020	The ratio between P − 2πR0 and 2πR0 was calculated as the EOPNE.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ratio", "between", "P", "−", "2πR0", "and", "2πR0", "was", ...
PMC11705067	Based on the above analysis results showing that FDX1 and DLAT are promising targets for ccRCC therapy, we predicted the corresponding drug targets through the DrugBank database, a drug target information source.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11763126	Methods: Peptide expression in ccRCC was analyzed using peptidomics technology to screen for potential antitumor peptides.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Peptide", "expression", "in", ...
PMC11139449	However, when a genomic forward primer and a primer flanked on the vector were used as the reverse primer, a 270 bp band was successfully amplified.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11476222	The lysates were then sonicated on ice for 60 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "lysates", "were", "then", "sonicated", "on", "ice", "for", "60", "min", "." ] ...
PMC8735881	As anticipated, the expression of the new constructs along with GPI-10E8 was readily detected by a western blotting assay in cell lysates but not in culture supernatants (Figure 6(B)); FACS analysis confirmed that each CMI inhibitor was efficiently expressed on the cell surface via a GPI anchor (Figure 6(C)) and did no...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11792766	Low concentrations of ethanol around 1 mM have been demonstrated to inhibit cell proliferation and induce apoptosis via Caspase‐3 activation, whereas higher concentrations close to 10 mM can lead to increased uncontrolled cell death and further inhibit proliferation in the HepG2 cell line (Castañeda & Kinne, 2000).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10222971	Derivatives 4 (2-butanoyloxy-1,4-naphthoquinone) and 10 (2-pentoxy-1,4-naphthoquinone) cause apoptosis to be the primarily cell death mechanism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Derivatives", "4", "(", "2-butano...
PMC9429973	Benefits of romiplostim treatment was confirmed both from physician’s and patient’s perspective.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Benefits", "of", "romiplostim", "treatment", "was", "confirmed", "both...
PMC5925824	Serially diluted LY3300054 or control IgG were mixed with the equal volume of a fixed concentration of biotinylated PD-L1-Fc (100 ng/mL for PD-1 blocking and 500 ng/mL for CD80 blocking), and then incubated at room temperature for 1 h. 100 μl of the mixture was transferred to 96-well plates pre-coated with human PD-1-F...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Twenty-one (91.3%) patients developed thrombocytopenia and HIT was excluded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Twenty-one", "(", "91.3", "%", ")", "patients", "developed", "thrombocytopenia", ...
PMC10719213	In summary, our work suggests that effective concentrations of cladribine do not alter mitochondrial genome integrity or mtDNA mutation levels in conventional T-cell lines and cultured ex vivo lymphocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11468365	The MultiComb model is evaluated using one of the challenging O’Neil datasets .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "MultiComb", "model", "is", "evaluated", "using", "one", "of", "the", ...
PMC11507371	Indeed, the increased basal antioxidant level (Figure 2B) of the unstressed tumour cells suggests that they already invest significantly more effort in the increased production of antioxidants in order to keep the intracellular ROS level at a stable cell-compatible level (homeostasis).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11748618	However, many host genomic studies do not accurately represent global genetic diversity, focusing mainly on individuals of European ancestry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "m...
PMC10589262	All data were analyzed using GraphPad Prism 7 (GraphPad Software Inc., La Jolla, CA, USA) and expressed as mean ± SEM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Despite seemingly favourable responses to SCT, these patients progressed quickly and were likely to receive a CAR-T treatment in 3L, indicating an unmet need and highlighting potentially high resource use and substantial impacts to quality of life.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10926885	For a number of malignancies, NDE1 may be a biomarker for immunotherapy and prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "a", "number", "of", "malignancies", ",", "NDE1", ...
PMC11317131	Notwithstanding, a key finding was that evolved integrases outcompeted wildtype integrases particularly well during pre-optimized, suboptimal transfection conditions (>6 fold) (Figure 5a and b) indicating that this technology might be suited for in-vivo gene delivery where tissue transfection efficiency can be difficul...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10820104	A comparable result was observed for fraction 5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "comparable", "result", "was", "observed", "for", "fraction", "5", "." ] } ]
PMC11803918	These results indicated that functional markers on the surface of hybrid exosomes could mediate the active targeting effect and promote drug delivery toward melanoma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11695546	There was a significant difference of anti-biofilm activity of cured and ozonized coconut oil (P≤0.05) upon using 25% of MBC towards H. pylori.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10914904	Additionally, the upregulation of vtRNA 1-1, 1-2, and 1-3 is facilitated by the NS1 IAV protein, resulting in the inhibition of the double-stranded (ds) RNA-dependent protein kinase PKR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11599565	Initially, we cultivated OC cells for one week in hanging drops (1000 cells in 25 µL) to obtain spheroids.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Initially", ...
PMC11488203	A significant growth reduction in A549 cells was observed with miR-193b-3p (25.4 ± 3%) and miR-766-3p (26.7 ± 4%) (Fig. 5A).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11599565	Multipotent adult progenitor cells (MAPC) are not only found in bone marrow but also distributed throughout all organs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Multipotent", "adult", "prog...
PMC11026382	It also allows one (in principle) to do the inverse: infer in vitro catalytic parameters from growth rate measurements.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "also",...
PMC11695623	However, the expression and biological function of DCUN1D5 in lung adenocarcinoma and the molecular mechanism of its action are not yet clear.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However...
PMC11453018	The breast carcinoma (T-47D) cell line was gift from Dr. Reuben Harris, University of Minnesota, rhabdomyosarcoma (A204) cell line was gift from Dr. Dennis Wigle, Mayo Clinic, synovial sarcoma (Fuji), osteosarcoma cell lines U2-OS, 143B, SJSA-1, HOS, and G292, also a gift from Dr. Beau Webber, University of Minnesota, ...	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "...
PMC11750161	G protein-coupled receptors (GPCRs) form the largest class of transmembrane cell surface receptors and regulate diverse intracellular signaling pathways in response to a wide range of extracellular stimuli (Lefkowitz & Shenoy, 2005; Lefkowitz et al., 2023).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11216402	Principal component analysis (PCA) of variation in the activity of distal peaks (Methods) showed significant heterogeneity in chromatin accessibility across the cell lines, forming three clusters (Fig. 1A) with similar genomic accessibility profiles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11635087	Algal chloroplast genomes typically contain only approximately 100 genes, but the schyzon genome includes 243 genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Algal", "chloroplast", "genomes", "typically", "c...
PMC9559528	Many lesions located on the trunk and extremities appeared targetoid, some with central crusted erosions, resembling erythema multiforme.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Many", "lesions", "located",...
PMC9429973	3 dose levels of venetoclax in combination with ASTX727 will be tested.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3", "dose", "levels", "of", "venetoclax", "in", "combination", "with", "ASTX727"...
PMC11634027	Some non-specific (ns) bands are indicated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "non-specific", "(", "ns", ")", "bands", "are", "indicated", "." ] } ]
PMC10968586	A 16 h incubation with 400 μM HT triggered endoplasmic reticulum stress in HT-29 cells, with activation of unfolded protein response, as indicated by the increase in the spliced form of X-box binding protein 1 (XBP-1) mRNA, the upregulation of chaperone 78 kDa glucose-regulated protein (GRP78/Bip) at both mRNA and prot...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11509224	Compound 41 showed cytotoxicity against the HL-60 and K562 cell lines, with IC50 values of 33.0 and 39.2 µM, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compound", "...
PMC9429973	Lethality rates reported for these patients are higher than general population and there is a trend towards a greater impact in patients diagnosed in the last 5 years.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8903741	Mix and Comm.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Mix", "and", "Comm", "." ] } ]
PMC11371747	LV is commonly administered as a racemic mixture of its l-LV and d-LV stereoisomers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LV", "is", "commonly", "administered", "as", "a", "racemic", "mi...
PMC10919056	TMB refers to the number of gene mutation sites that occur in tumor tissues and includes somatic gene coding errors, base substitutions, insertions or deletions (19).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9341513	Or, in other words, a genomic translocation leads to an epigenomic translocation, which drives cyclin D1 overexpression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Or", ",", "in", "other...
PMC10654497	The gene expression of SLC3A2, SLC16A1, SLC39A14, SLC39A7, SLC1A5, and SLC11A2 in the lung adenocarcinoma cell line A-549 and H1299 is higher than that in the normal lung epithelial cell line Beas-2B (Fig. 10A–L).Figure 10Q-PCR. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "B-CellLine", ...
PMC11453018	A Heatmap illustrates the gene expression profiles of ES cells treated with iP300w (1 µM) for 4 hours, with hierarchical clustering indicating significant concordance among different ES samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11531735	The quantification of fluorescent intensity, represented as total flux (photons/second), was carried out by delineating ROI (region of interest) for both control and experimental/treatment groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7154001	Two independent researchers performed data extraction from all articles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "independent", "researchers", "performed", "data", "extraction", "from", "all", "articles", "." ]...
PMC11548041	The cells were washed and incubated with 5 µg/mL Alexa Fluor 647 conjugated streptavidin (Strep-AF647, Thermo Fisher Scientific) for 30 min on ice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11291697	HPLC analysis was performed on serum, LCL and cell culture supernatant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HPLC", "analysis", "was", "performed", "on", "serum", ",", "LCL", "and", "...
PMC11279397	For instance, classical Chinese medicine formulas like “Guizhi Soup” in Zhang Zhongjing’s “Typhoid Theory” feature Perilla frutescens as the principal herb for treating fever and headache caused by external wind-cold pathogens.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11592837	By contrast, ETP inhibits the DNA unwinding function of topoisomerase II through direct protein interaction .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "contrast", ",", "ETP", "inhibits", "the", ...
PMC8978939	All the systems were solvated with a truncated-octahedral box of TIP3P water 12 Å around the solute and neutralized with K ions using the leap module of AmberTools17 (45).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	RS, gwava, phast, ReMM) and CpG region, TFBS and miRNA binding site.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RS", ",", "gwava", ",", "phast", ",", ...
PMC11731614	These data strongly suggest that CD63-GFP-positive KDEVs are retrogradely transported from the epidermis to DRG neuron cell bodies, representing a novel mode of communication.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11759751	The killing of B-NHL cells by CD19 CAR T cells after pretreatment with chidamide (C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "killing", "of", "B-NHL", "cells", "b...
PMC11798926	As an additional control (E), to randomize the data, the SynDIG4 channel was rotated 90 degrees, and the Manders correlation coefficient (MCC) was recalculated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11730305	This study showed that Co3O4@Glu-Ellagic acid NPs have considerably higher cytotoxic effects on liver cancer cells and led to cell cycle arrest, often at the subG1 phase, and triggered apoptosis by the generation of oxidative stress.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721277	In the H NMR spectrum of the synthesized substance, the signals of the aromatic protons were detected in the low field range.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC9429973	Aims: Assess the AL Amyloidosis patient journey, understand treatment strategies in Portugal as well as unmet needs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "Assess", "the", ...
PMC8903741	After concentrating each purified antibody by employing an ultrafiltration system, we addressed the concentration of antibodies with a nanodrop and determined the samples by SDS-PAGE.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11543853	Enteroviruses enter cells by receptor-mediated endocytosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Enteroviruses", "enter", "cells", "by", "receptor-mediated", "endocytosis", "." ] } ]
PMC10729469	The left was immediately frozen on dry ice for biochemical analysis and the right was immersed in fresh, depolymerized 4% paraformaldehyde in PBS for 48 h at 4 °C and cryoprotected by immersion in 15% then 30% sucrose for 24 h/immersion at 4 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9019892	FGF/FGFRs can regulate several downstream intracellular pathways through the intracellular receptor substrate FGFR substrate 2 alpha (FRS2α), resulting in subsequent upregulation of the RAS/mitogen‐activated protein kinase (MAPK) and phosphoinositide 3‐kinase (PI3K)/AKT signalling pathways .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6222635	After treatment with DPFs and incubation for 48 h, protein was extracted from the cells using lysing reagents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "treatment", "with", "DPF...

PMC11718031

In particular, developing rational strategies for using feed/media in suitable combinations is essential for improving fed-batch cell cultures’ process efficiency (Shukla et al. 2017; Rasoul et al. 2019).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11711063

Furthermore, the downregulation of E‐cadherin by ZG16B is commensurate with the loss of epithelial characteristics, decreased cell–cell adhesion and cancer progression.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11792740

Furthermore, T-cell depletion influences the selection of immunotherapeutic strategies.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "T-cell", "depletion", "influences", "the", "selection", "of", "immunotherapeutic",...

PMC11468365

represents the set of edges that can be defined by an adjacency matrix .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "represents", "the", "set", "of", "edges", "that", "can", "be", "defin...

PMC11721587

Flag-Fu proteins expressed in Sf9 cells at high MOI were separated into S100 and P100 fractions and then incubated with or without MPA in the presence of Sufu-Ci complexes purified from Sf9 cells for 6 hours, followed centrifugation into S100 and P100 fractions and immunoblot analysis with the indicated antibodies. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6267596

Volcano plots that co-visualize Log2 fold changes and -Log10 P-value for each protein revealed that 8 proteins were significantly up-regulated and 6 proteins were down-regulated in both cell lines.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11687167

In summary, STAT molecules promote Th cell differentiation and Treg expansion, while STAT3 phosphorylation and JAK1/2 inhibit PCSK9 expression.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "summary", "...

PMC10854447

All tested compounds will likely be metabolised by CYP1A2, CYP2C19, and CYP2C9 but will be CYP2D3 inhibitors.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "tested", "compounds", "wil...

PMC11683240

This observation suggests that the inhibition of PT may not be reliant on α1AT’s protease inhibitor activity since another protease, antithrombin, does not have inhibitory effects on PT.Figure 3Effect of the serpin proteins α1AT and antithrombin on intoxication of CHO-K1 cells with PT.A–C, PT (10 ng/ml) and α1AT (100 μ...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11342785

The IDR fragments were fused with TPPPCORE domain(aa.45–166) into the same pBh4-His-GFP plasmid.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "IDR", "fragments", "were", "fused", "with", "TPPPCORE", "...

PMC9429973

IC treatment was daunorubicin 60 mg/m x 3 days, cytarabine 200 mg/m x 7 days, followed by 1-3 additional chemotherapy cycles.

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PMC11747467

Additionally, normalized mRNA expression data from GSE13507, GSE32894, GSE48075, GSE48276, and single-cell RNA-sequencing data from GSE135337 were retrieved from the Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/gds).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11725127

However, HSP90 inhibitor STA9090 treatment cannot reduce the protein level of KRAS in MM.1S cells, indicating that KRAS is not a substrate of HSP90 (Supporting Information Fig. S3).

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PMC9429973

Median OS for treatment naïve patients at DLBCL-RS diagnosis was not reached.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "OS", "for", "treatment", "naïve", "patients", "at", "DLBCL-RS", "diagn...

PMC11798926

Cells from both cultures were maintained in wild-type rat-derived astrocyte-conditioned neuron maintenance medium (NMM) consisting of 1X Neurobasal (NB) medium (Gibco #21103049), 1X GlutaMAX (Gibco #35050061), and 1X B-27 supplement (Gibco #17504044).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8708099

Osthole reduced the secretion of cytokines (CKs) and the expression level of inflammation-associated genes, which were increased after a histamine treatment.

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PMC11661040

Some studies have suggested that activation of the Wnt signaling pathway promotes OS growth(Kansara et al. 2009; Ji et al. 2015; Wen et al. 2021; Liu et al. 2018; Matsuoka et al. 2020), while others have come to the opposite conclusion(Cai et al. 2010).

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PMC9512971

Specifically, in PK/pharmacodynamic (PD) simulations, the times above the EC50 of camostat mesilate at doses of 800 mg three times daily and 600 mg qid were 9.8 h and 11.5 h, respectively .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11629192

OFA treatment is safe and effective, easy to administer, and favorable for pediatric anti-NMDAR encephalitis patients who are refractory to the first-line immunotherapy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11783017

This process attracts various immune cells to the tumor microenvironment, transforming "cold" tumors into "hot" tumors [, , ].

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11740207

EVs are tiny, membrane-enclosed particles released by cells during various biological activities.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EVs", "are", "tiny", ",", "membrane-enclosed", "particles", "released", "by...

PMC9429973

Summary/Conclusion: Use of targeted NGS has dramatically enhanced the efficiency of genotyping for patients with DBA and other inherited bone marrow failure syndromes, allowing for focused management of patients and discovery of novel genotype-phenotype correlations.

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PMC9429973

One patient did not show CNAs in the analyzed samples (5%).

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PMC11607321

Taken together, these diverse examples demonstrate MOSA’s ability to perform both partial and full dataset augmentation validated using various independent datasets and from different laboratories.

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PMC11737091

Correlation analysis between DBF4 and immunomodulatory genes Numerous studies have shown that the host immune response determines the progression of cancers.

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PMC11747949

Treatment did not induce differences in tumor growth (Figure 3A) or metastatic burden in lungs from mice who received CCR2 antagonist compared to vehicle control (Figure 3B,C).

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PMC11680049

In this cultivation variant, the callus tissue exhibited a loose consistency and formed a yellow-brown color (Figure 4d,e. However, it is important to note that the percentage of callus formation did not exceed 10%, and the onset of callusogenesis was only observed between the 30th and 40th days.

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PMC11721277

The aim of this work was the synthesis of natural chlorin that contains a fragment of 6-hydrazinylnicotinic acid.

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PMC9739791

The fluorescence quantum yield of prodrug 30, as well as its fluorescence lifetime, was significantly lower than for PPE (Table 11).

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PMC11322866

However, the distribution of Lamin B1 in the nuclear envelope was abnormal in RRM2 OE- or GSK126-treated cells, which was characterized by (1) partial absence in the inner nuclear envelope; (2) diffusion within the nucleus or along the periphery of the nuclear envelope without a discrete boundary; and (3) an increase i...

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PMC11519583

The experimental design is shown in (c), and relative mean intensity of Ki-67 is shown in (d) (n = 6).

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PMC7334607

Genes with Significant Differential Expression between SP-Resistant and SP-Sensitive Samples Differential gene expression analysis was performed using EBSeq in R, with maxround set to 15 and FDR of 0.05.

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PMC11670954

The optimal treatment conditions were determined to be 0.2 mmol/L BA and 5 μg/mL LPS for 24 hours.

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PMC10706275

This pursuit aims to enhance the advancement of stable cell lines for application in industrial settings.

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PMC11089031

The results of the wound healing assay showed that the migration of ccRCC cells was inhibited when ZNF692 was knocked down, while the migration of ccRCC cells was promoted when ZNF692 was overexpressed (Fig. 3H–J).

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PMC7887261

Genetic ancestry analysis of TCGA patients shows the vast majority of subjects with “unknown” race were primarily genetic European ancestry (i.e., 90% TCGA-LCs were genetically Europeans). #

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PMC11637276

Collagen I dishes were labelled with either 300 μl of 10 μg/ml NHS-fluorescein, 5 μg/ml Alexa Fluor 555 NHS ester, or 20 μg/ml pHrodo iFL red.

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PMC11224020

The ratio between P − 2πR0 and 2πR0 was calculated as the EOPNE.

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PMC11705067

Based on the above analysis results showing that FDX1 and DLAT are promising targets for ccRCC therapy, we predicted the corresponding drug targets through the DrugBank database, a drug target information source.

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PMC11763126

Methods: Peptide expression in ccRCC was analyzed using peptidomics technology to screen for potential antitumor peptides.

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PMC11139449

However, when a genomic forward primer and a primer flanked on the vector were used as the reverse primer, a 270 bp band was successfully amplified.

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PMC11476222

The lysates were then sonicated on ice for 60 min.

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PMC8735881

As anticipated, the expression of the new constructs along with GPI-10E8 was readily detected by a western blotting assay in cell lysates but not in culture supernatants (Figure 6(B)); FACS analysis confirmed that each CMI inhibitor was efficiently expressed on the cell surface via a GPI anchor (Figure 6(C)) and did no...

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PMC11792766

Low concentrations of ethanol around 1 mM have been demonstrated to inhibit cell proliferation and induce apoptosis via Caspase‐3 activation, whereas higher concentrations close to 10 mM can lead to increased uncontrolled cell death and further inhibit proliferation in the HepG2 cell line (Castañeda & Kinne, 2000).

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PMC10222971

Derivatives 4 (2-butanoyloxy-1,4-naphthoquinone) and 10 (2-pentoxy-1,4-naphthoquinone) cause apoptosis to be the primarily cell death mechanism.

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PMC9429973

Benefits of romiplostim treatment was confirmed both from physician’s and patient’s perspective.

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PMC5925824

Serially diluted LY3300054 or control IgG were mixed with the equal volume of a fixed concentration of biotinylated PD-L1-Fc (100 ng/mL for PD-1 blocking and 500 ng/mL for CD80 blocking), and then incubated at room temperature for 1 h. 100 μl of the mixture was transferred to 96-well plates pre-coated with human PD-1-F...

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PMC9429973

Twenty-one (91.3%) patients developed thrombocytopenia and HIT was excluded.

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PMC10719213

In summary, our work suggests that effective concentrations of cladribine do not alter mitochondrial genome integrity or mtDNA mutation levels in conventional T-cell lines and cultured ex vivo lymphocytes.

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PMC11468365

The MultiComb model is evaluated using one of the challenging O’Neil datasets .

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PMC11507371

Indeed, the increased basal antioxidant level (Figure 2B) of the unstressed tumour cells suggests that they already invest significantly more effort in the increased production of antioxidants in order to keep the intracellular ROS level at a stable cell-compatible level (homeostasis).

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PMC11748618

However, many host genomic studies do not accurately represent global genetic diversity, focusing mainly on individuals of European ancestry.

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PMC10589262

All data were analyzed using GraphPad Prism 7 (GraphPad Software Inc., La Jolla, CA, USA) and expressed as mean ± SEM.

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PMC9429973

Despite seemingly favourable responses to SCT, these patients progressed quickly and were likely to receive a CAR-T treatment in 3L, indicating an unmet need and highlighting potentially high resource use and substantial impacts to quality of life.

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PMC10926885

For a number of malignancies, NDE1 may be a biomarker for immunotherapy and prognosis.

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PMC11317131

Notwithstanding, a key finding was that evolved integrases outcompeted wildtype integrases particularly well during pre-optimized, suboptimal transfection conditions (>6 fold) (Figure 5a and b) indicating that this technology might be suited for in-vivo gene delivery where tissue transfection efficiency can be difficul...

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PMC10820104

A comparable result was observed for fraction 5.

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PMC11803918

These results indicated that functional markers on the surface of hybrid exosomes could mediate the active targeting effect and promote drug delivery toward melanoma cells.

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PMC11695546

There was a significant difference of anti-biofilm activity of cured and ozonized coconut oil (P≤0.05) upon using 25% of MBC towards H. pylori.

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PMC10914904

Additionally, the upregulation of vtRNA 1-1, 1-2, and 1-3 is facilitated by the NS1 IAV protein, resulting in the inhibition of the double-stranded (ds) RNA-dependent protein kinase PKR.

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PMC11599565

Initially, we cultivated OC cells for one week in hanging drops (1000 cells in 25 µL) to obtain spheroids.

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PMC11488203

A significant growth reduction in A549 cells was observed with miR-193b-3p (25.4 ± 3%) and miR-766-3p (26.7 ± 4%) (Fig. 5A).

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PMC11599565

Multipotent adult progenitor cells (MAPC) are not only found in bone marrow but also distributed throughout all organs.

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PMC11026382

It also allows one (in principle) to do the inverse: infer in vitro catalytic parameters from growth rate measurements.

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PMC11695623

However, the expression and biological function of DCUN1D5 in lung adenocarcinoma and the molecular mechanism of its action are not yet clear.

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PMC11453018

The breast carcinoma (T-47D) cell line was gift from Dr. Reuben Harris, University of Minnesota, rhabdomyosarcoma (A204) cell line was gift from Dr. Dennis Wigle, Mayo Clinic, synovial sarcoma (Fuji), osteosarcoma cell lines U2-OS, 143B, SJSA-1, HOS, and G292, also a gift from Dr. Beau Webber, University of Minnesota, ...

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PMC11750161

G protein-coupled receptors (GPCRs) form the largest class of transmembrane cell surface receptors and regulate diverse intracellular signaling pathways in response to a wide range of extracellular stimuli (Lefkowitz & Shenoy, 2005; Lefkowitz et al., 2023).

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PMC11216402

Principal component analysis (PCA) of variation in the activity of distal peaks (Methods) showed significant heterogeneity in chromatin accessibility across the cell lines, forming three clusters (Fig. 1A) with similar genomic accessibility profiles.

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PMC11635087

Algal chloroplast genomes typically contain only approximately 100 genes, but the schyzon genome includes 243 genes.

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PMC9559528

Many lesions located on the trunk and extremities appeared targetoid, some with central crusted erosions, resembling erythema multiforme.

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PMC9429973

3 dose levels of venetoclax in combination with ASTX727 will be tested.

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PMC11634027

Some non-specific (ns) bands are indicated.

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PMC10968586

A 16 h incubation with 400 μM HT triggered endoplasmic reticulum stress in HT-29 cells, with activation of unfolded protein response, as indicated by the increase in the spliced form of X-box binding protein 1 (XBP-1) mRNA, the upregulation of chaperone 78 kDa glucose-regulated protein (GRP78/Bip) at both mRNA and prot...

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PMC11509224

Compound 41 showed cytotoxicity against the HL-60 and K562 cell lines, with IC50 values of 33.0 and 39.2 µM, respectively.

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PMC9429973

Lethality rates reported for these patients are higher than general population and there is a trend towards a greater impact in patients diagnosed in the last 5 years.

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PMC8903741

Mix and Comm.

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PMC11371747

LV is commonly administered as a racemic mixture of its l-LV and d-LV stereoisomers.

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PMC10919056

TMB refers to the number of gene mutation sites that occur in tumor tissues and includes somatic gene coding errors, base substitutions, insertions or deletions (19).

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PMC9341513

Or, in other words, a genomic translocation leads to an epigenomic translocation, which drives cyclin D1 overexpression.

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PMC10654497

The gene expression of SLC3A2, SLC16A1, SLC39A14, SLC39A7, SLC1A5, and SLC11A2 in the lung adenocarcinoma cell line A-549 and H1299 is higher than that in the normal lung epithelial cell line Beas-2B (Fig. 10A–L).Figure 10Q-PCR. (

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PMC11453018

A Heatmap illustrates the gene expression profiles of ES cells treated with iP300w (1 µM) for 4 hours, with hierarchical clustering indicating significant concordance among different ES samples.

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PMC11531735

The quantification of fluorescent intensity, represented as total flux (photons/second), was carried out by delineating ROI (region of interest) for both control and experimental/treatment groups.

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PMC7154001

Two independent researchers performed data extraction from all articles.

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PMC11548041

The cells were washed and incubated with 5 µg/mL Alexa Fluor 647 conjugated streptavidin (Strep-AF647, Thermo Fisher Scientific) for 30 min on ice.

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PMC11291697

HPLC analysis was performed on serum, LCL and cell culture supernatant.

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PMC11279397

For instance, classical Chinese medicine formulas like “Guizhi Soup” in Zhang Zhongjing’s “Typhoid Theory” feature Perilla frutescens as the principal herb for treating fever and headache caused by external wind-cold pathogens.

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PMC11592837

By contrast, ETP inhibits the DNA unwinding function of topoisomerase II through direct protein interaction .

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PMC8978939

All the systems were solvated with a truncated-octahedral box of TIP3P water 12 Å around the solute and neutralized with K ions using the leap module of AmberTools17 (45).

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PMC9429973

RS, gwava, phast, ReMM) and CpG region, TFBS and miRNA binding site.

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PMC11731614

These data strongly suggest that CD63-GFP-positive KDEVs are retrogradely transported from the epidermis to DRG neuron cell bodies, representing a novel mode of communication.

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PMC11759751

The killing of B-NHL cells by CD19 CAR T cells after pretreatment with chidamide (C).

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PMC11798926

As an additional control (E), to randomize the data, the SynDIG4 channel was rotated 90 degrees, and the Manders correlation coefficient (MCC) was recalculated.

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PMC11730305

This study showed that Co3O4@Glu-Ellagic acid NPs have considerably higher cytotoxic effects on liver cancer cells and led to cell cycle arrest, often at the subG1 phase, and triggered apoptosis by the generation of oxidative stress.

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PMC11721277

In the H NMR spectrum of the synthesized substance, the signals of the aromatic protons were detected in the low field range.

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PMC9429973

Aims: Assess the AL Amyloidosis patient journey, understand treatment strategies in Portugal as well as unmet needs.

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PMC8903741

After concentrating each purified antibody by employing an ultrafiltration system, we addressed the concentration of antibodies with a nanodrop and determined the samples by SDS-PAGE.

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PMC11543853

Enteroviruses enter cells by receptor-mediated endocytosis.

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PMC10729469

The left was immediately frozen on dry ice for biochemical analysis and the right was immersed in fresh, depolymerized 4% paraformaldehyde in PBS for 48 h at 4 °C and cryoprotected by immersion in 15% then 30% sucrose for 24 h/immersion at 4 °C.

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PMC9019892

FGF/FGFRs can regulate several downstream intracellular pathways through the intracellular receptor substrate FGFR substrate 2 alpha (FRS2α), resulting in subsequent upregulation of the RAS/mitogen‐activated protein kinase (MAPK) and phosphoinositide 3‐kinase (PI3K)/AKT signalling pathways .

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PMC6222635

After treatment with DPFs and incubation for 48 h, protein was extracted from the cells using lysing reagents.

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