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OTAR3088
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BioData-CellLine_annotated

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PMC9812014
RSV is one of the most prevalent viruses that cause respiratory diseases in newborns, the elderly, and those with weakened immune systems, resulting in substantial infection rates worldwide each year .
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PMC11684821
Jurkat cells expressing MC.7.G5, MC.27.759S, K8T-1, or K8T-2 TCRs responded to MR1*01 homozygous or MR1*01/*02 cancer cell lines but, collectively, did not respond to monocytes or B cells from sixteen different healthy donors (Figure 2, F and G and Figure 6).
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PMC11095939
Methyl-CpG binding protein 2 (Mecp2), as a chromatin-binding protein (Lee et al., 2020; Tillotson and Bird, 2020), plays multiple roles in gene expression regulation, including transcriptional activation and repression, RNA splicing, chromatin remodeling, and regulation of chromatin architecture (Ezeonwuka and Rastegar...
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PMC9813422
Episomal modification and nucleosome positioning play a role in both activation and inactivation of latent genes (12).
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PMC6835428
Interestingly, the mathematical approach is in line with Leonardo da Vinci’s conviction that “niuna umana investigazione si può dimandare vera scientia s’essa non passa per le matematiche dimostrazioni” (no human investigation can be defined true science if it cannot be mathematically demonstrated). .
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PMC11742864
These findings collectively indicated ω-3 LCPUFAs induced apoptosis via regulating the enzymatic activity of caspases, thereby preventing tumor development.
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PMC11106977
RA is a chronic inflammatory joint disease associated with loss of cartilage, bone damage, and disability .
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PMC8984067
UCNPs, UCNPs-Ce6, and anti-EpCAM-UCNPs-Ce6 had zeta potentials of 32.1, 17.5, and 10.2 mV, respectively.
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PMC11607321
By using the view dropout layer, we significantly improved the latent space cell line separation (Fig. 1c, Supplementary Figs. 1b, 10a, b) and reconstruction for both the proteomic (Fig. 3a, Supplementary Fig. 10c) and drug response data (Supplementary Fig. 10d).
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PMC10165258
This loading protocol resulted in around 200 cells per 540 nL droplet and the chip was then placed inside a cell incubator at C, 5% in between experiments.
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PMC11394227
The GSH/tGSH ratios of CHO-PAb cells and CHO-PAb-QS cells were 88.8% and 85.9%, respectively.
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PMC11352877
The aim of this study is to investigate the mRNA expression levels of key angiogenic factors (VEGF-A, TGF-β1, ANG1/2, and HIF-1α) in endometrial and ovarian endometrioid cell lines and elucidate their impact on cell migration, thereby advancing our understanding of the mechanisms underlying pathological angiogenesis in...
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PMC11487720
UV/cold shock downregulated WWOX, TRAF2 and α-Tubulin proteins by ~ 50%.
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PMC10723784
Carboplatin induced much less cytotoxicity in A2780/CP70 cells compared to A2780 cells in all contact points tested.
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PMC10831439
Data were obtained after gating on all cells (FSC-A vs SSC-A), singlets (SSC-A vs SSC-W) and annexin V−VD−CTV+ cells. (
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PMC9429973
TRPH-222 was administered IV once every 3 weeks.
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PMC11737091
The paraffin-embedded tissues were deparaffinised via the standard xylene-deparaffinisation procedure, stained with anti-DBF4 (BIOSS antibodies, bs-7895R) at 4 °C overnight, and then incubated with an HRP-conjugated secondary antibody (Cell Signalling Technology, #7074S, 1:1,000 dilution) for 1 h at 37 °C.
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PMC2944824
Viability was measured by the MTT assay in triplicates in three independent experiments (A) and caspase-3 activity was measured as described in figure 1 (B) in three independent experiments in duplicates.
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PMC11637716
Later in the clinical course, the patient in addition developed endocrine pancreatic insufficiency with impaired glucose tolerance.
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PMC11488203
Untreated A549 cells served as a control (medium control) and the different concentrations of taxol substance (0.1 nM; 1 nM; and 10 nM) were used as a reference for cytotoxicity (C).
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PMC3164356
Furthermore, several histone proteins involved in nucleosome assembly do not show any detectable expression in the CHO-K1 transcriptome (Fig. 4a).
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PMC8389560
It was found that the obtained preparation of selenium nanoparticles has a monomodal size distribution.
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PMC11470999
Our previous research showed that PP2A dephosphorylates XPO5 and regulates its transport capacity, thereby promoting the biosynthesis of tumor‐suppressing miRNAs such as miR‐122 and miR‐200b. ,
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PMC11367146
The compound-target-disease network constructed by Cytoscape v_3.9.1 linking the OA-related targets with the compounds of VTE.
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PMC7812570
Accordingly, TZM-bl target cells were transduced with GPI-m36.4 or GPI-FluIgG03 and cocultured with CEMss-CCR5 cells without the addition of DEAE-dextran.
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PMC9960565
The mass spectrometry analysis was conducted using the electrospray ionization technique (ESI), in positive mode, with the QTOF hybrid analyzer model MAXIS II from Bruker at the Mass Spectrometry Unit at Interdepartmental Investigation Service at Universidad Autónoma de Madrid, Spain, and with the Bruker Autoflex maX M...
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PMC11012313
A minimum of three replicates were used per experimental group with variation in CT values among replicates less than 0.5.
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PMC9429973
In the group lacking MECOM expression we identified HMX3 as most influential transcription factor.
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PMC10890055
There are two main options for choosing the in vitro model: primary cells or cancer-derived cell lines.
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PMC11612315
This result indicates that exendin 20–29 is less likely to interact with GLP-1R (Fig. 8g).
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PMC9872547
E7 protein can disrupt the Rb, terminates their association with the E2F transcription factor family, and destroys cell cycle regularity (16).
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PMC11499381
This antibody-based detection method only detects receptors on the cell surface, as opposed to receptor expression within the cell .
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PMC9541067
j–l The values of the band intensity represent the densitometric estimation of each band normalised by β-actin in (b–f, respectively). (*
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PMC11320834
The FDA and EMA have approved olaparib as a first-line treatment for primary and recurrent platinum-sensitive ovarian tumors.
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PMC9429973
M. Haselager, E. Perelaer, A. Kater, E. Eldering Experimental Immunology, Amsterdam University Medical Center; Lymhoma and Myeloma Center Amsterdam, LYMMCARE; Cancer Center Amsterdam; Amsterdam Infection & Immunity Institute; Hematology, Amsterdam University Medical Center, Amsterdam, Netherlands Background: Primary ch...
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PMC11674891
Previous research indicates that GRPR signaling induces transcription and DNA synthesis in human pancreatic adenocarcinoma cells and regulates Cox-2 mRNA expression in various tissues .
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PMC11792090
p < 0.0001; ns, not significant.
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PMC11770130
All the P-values were calculated via t-test with post-hoc correction unless specifically indicated.
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PMC11564405
of patientsRILPL2P valueLow (N = 97)High (N = 43)Age(years)Median (range)63(30–84)62(25–78)Gender Male11175(67.6%)36(32.4%)0.389 Female2922(75.9%)7(24.1%)Stage I–IIIA11474(64.9%)40(35.1%)0.019I IIB–IV2623(88.5%)3(11.5%)Tumor size (cm) ≤ 33219(59.4%)13(40.6%)0.166 > 310878(72.2%)30(27.8%)Lymph node metastasis No6747(70....
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PMC11106977
GFAT-1 is also known to regulate adipogenesis by increasing the expression levels of critical transcription factors (C/EBPβ, PPARγ), fatty acid synthase (FAS), and lipid droplet (LD) proteins in 3T3-L1 cells .
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PMC11489351
Scatter plot (mean ± SEM) from four biological replicates.
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PMC8806312
GSEA demonstrated significant enrichment of the 4-gene signature associated with chemokine and B cell receptor signaling pathways, CCR interaction, and CAMs.
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PMC10170482
Collagen fibers were stained with ColF (green).
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PMC9429973
CTX130 had an acceptable safety profile across all DLs.
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PMC10810426
However, it is possible that the low-level integration detected in serum-starved cells resulted from incomplete inhibition of cell division, since the reduction in cell division was incomplete (75–85%) (Figs 1D and S2).
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PMC11792740
ʟ-arginine deprivation also suppresses T-cell responses in tumors.
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PMC11785489
Clusters A1–A9 were identified by clustering resolution 0.5.
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PMC10197932
Furthermore, we have evaluated maximal physiological ROS production and their tolerance.
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PMC9429973
Early, deep and durable responses were seen in triple- to penta-refractory pts with RRMM, with a 75.0% response rate at the combined 200–800 mg dose levels.
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PMC9429973
However, the in vitro deletion of the CACCC box of the HBB gene shows that EKLF may also be involved in the regulation of the beta globin gene independently of the proximal CACCC motif, a hypothesis that suggests the role of other upstream CACCC elements on the LCR.
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PMC11423992
In contrast, a control assay without target cells showed no detectable release of cytokines.
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PMC9429973
The median duration of follow up was 2.9 yrs.
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PMC9429973
Summary/Conclusion: This data acquired in the community setting demonstrate low T cell response rates and better humoral response rates to SARS-CoV2 vaccination in actively treated MM patients.
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PMC9429973
We used the Kaplan-Meier and the Cox method to analyze overall survival (OS), with a two-sided P value ≤ 0.15 for a factor in the univariate analysis to be included in the multivariate regression, where a P value ≤ 0.05 was considered statistically significant.
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PMC11767793
Positive control biological activity should be based on a similar mechanism of action as that of the assay that is used.
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PMC11377827
The role of 14-3-3 proteins in HIF signalling has not been well explored.
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PMC9672323
302,901) antibodies and treated with different concentrations of drugs (piroxicam: 0, 3, 14, and 30 µM; and dexamethasone: 0, 0.1, 0.5, 1 µM) for 72 h in 48-well plates; for each cell line, 7 × 10 cells were cultivated with the same concentration of drugs and the same incubation condition.
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PMC8751435
The data represent the mean ± SD of six replicates and three independent experiments. *
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PMC11527437
Benchmarking the antitumor activity of the TCRs against other published HLA-A*03:01– and HLA-A*11:01–restricted KRAS G12V-targeting TCRs (12, 13) would be interesting.
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PMC11477621
Specific procedures were referred to the reported method .
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PMC11052306
At the concentration of 100 µM, all the SF188 cells were killed by 9-G0-Cu5 and by 9-G0-[Au5][AuCl4]5, but only about 50% of the SF188 cells were killed by temozolomide.
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PMC11657695
D ITGB2 and ITGB3 normalized gene expression in A-673 cell line (N = 4).
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PMC6642070
The human colon cancer HCT116 SCO2−/− cell line was a generous gift from Dr. Paul M. Hwang at the National Institutes of Health, and cultured in McCoy's 5A medium.
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PMC11754436
CCK-8 results showing proliferation level over 4 consecutive days for MG63 cells in each group, *Represent comparison with the NC group. (
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PMC9429973
Summary/Conclusion: Using large-scale MPN patient cohorts, we are able to elucidate biology underlying MPN disease.
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PMC9917080
Camera settings were 500 pixels × 500 pixels (Voxel Size 0.724 μm × 0.723 μm), binning 2 × 2, resolution 14 bits .
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PMC11247842
The raw reads were subjected to Trimmomatic 0.38 with recommended parameters to remove adapter sequence and to trim low-quality bases.
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PMC10366908
These failures cost significant amounts of money and reduce the patient’s quality of life.
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PMC9577200
These findings reveal that GO is a general growth enhancer but not a bactericidal or bacteriostatic agent.
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PMC10523483
We performed qPCR to investigate the key enzymes involved in H1.2-mediated GSH homeostasis and found significantly lower Gclc level in KH lung tumors, while the others showed no significant alteration (Fig. 2 J and K).
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PMC11597167
Then, 10,000 SH-SY5Y cells in 100 µL of complete medium were seeded in each well of a 96-well plate and incubated for 16–24 h for surface attachment.
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PMC11449273
As a first step in our investigations, we confirmed that exogenously expressed plakoglobin interacted with exogenously expressed p53-WT, p53-R175H (p53-175) and p53-R273H (p53-273) similarly in H1299 cells.
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PMC10850553
This cascade may become a therapeutic target to prevent the rupture of IAs.
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PMC7351993
First, we performed high-purity enrichment of polymer particles (see “preparation of polymer particles” in the Methods section for details).
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PMC9429973
History of consanguinity was documented in 175 cases (80%).
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PMC11621493
BAT, brown adipose tissue; CM, cardiac muscle; iWAT, inguinal white adipose tissue; gWAT, gonadal white adipose tissue; SM, skeletal muscle; SI, small intestine; PLA2G4, phospholipase A2 group IV.
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PMC11754432
The detected increase in M1 and reduction in EGFR protein indicates an increase in the trafficking of EGFR into the lysosomal region and therefore degradation of the receptor.
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PMC11471176
Inhibition kit fluorescence detected at Ex/Em = 320/420 nm for the different time points in Mean ± Standard Deviation with Linear Trendline Slopea and % Inhibition Averageb below.
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PMC10582049
In addition, stratified Kaplan–Meier plots were generated using available web Kaplan–Meier plotter.
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PMC8662250
CBD effect resulted in a significant and concentration‐dependent inhibition of both TLR4 (−28%, −41%, −76% respectively vs. SP 10 ng/ml group) and ACE‐2 protein expression (−25%, −38.4%, and −57% vs. SP 10 ng/ml group) paralleled to a marked rescue of RhoA GTP (+83%, +365% and +490% vs. SP 10 ng/ml) expression (Figure ...
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PMC7812570
Taken together, these data indicate that GPI-anchored m36.4 can render CD4 T cells extremely resistant to both CCR5- and CXCR4-tropic HIV-1 isolates.
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PMC11697065
Missed cleavage= 1 and maximum variable modifications= 2.
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PMC10976516
These results and those from many other studies continue to emphasize the importance of carrier cells for the improved use of OV therapy against not only lung cancer but most other solid cancers too.
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PMC11279397
Cinnamaldehyde (CA) serves as a naturally occurring active ingredient well tolerated by both humans and animals.
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PMC11429241
Specifically, scaffolds significantly enhanced the 3D-growth-related gene expression profile in the A2780 cells, providing a valuable means to improve their 3D structure formation ability.
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PMC11036064
.
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PMC11748335
F Normalized gene expression levels within the three groups of LOCKs in common PMDs, for NE2 and KYSE450.
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PMC10253973
Hence, ruthenium has become a special point of interest in the development of metallopharmaceuticals.
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PMC9429973
Aims: We performed single-cell RNA sequencing (scRNA-seq) for immune and tumor cells of TFH lymphoma to determine (1) the specific immune profiles, (2) the characteristics of tumor cells and (3) the mechanisms of clonal evolution from G17V Hetero to Homo.
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PMC11697065
Different cell growth phases have distinctive metabolic pathways, reflected in the specific proteins involved in these circuits .
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PMC11442172
Although a considerable number of studies have addressed the metabolic differences between 2D and 3D cultures, fewer studies make the comparison between these in vitro systems and the metabolic profiles found in primary tumor tissues.
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PMC9429973
A relapse occured in 6 patients out of 11(CR+VGPR+RP) after a median time of 29 months.
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PMC11525028
ASNS knockout induced a significant decrease of N-Asn derived from N-Asp in ASNS-knockout cell lines (Figure 4U).
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PMC10919056
The HK2 and A498 cells were cultured in Dulbecco’s modified eagle medium (DMEM) supplemented with 10% fetal bovine serum (FBS) at 37°C in a 5% CO2 incubator; the 786-O cells were cultured in Roswell Park Memorial Institute-1640 (RPMI-1640) supplemented with 10% FBS at 37°C in a 5% CO2 incubator.
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PMC11704135
FT-IR spectra were recorded on Bruker, Tensor 27 FT-IR spectrophotometer with frequency range 4000 cm to 400 cm (Central Lab, Tanta University, Egypt) with KBr pellets.
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PMC11224020
As observed for cPLA2, ARP2/3 inhibition had no effect on LPS-induced CCR7 upregulation (Extended Data Fig. 3c).
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PMC10218459
Since conclusive evidence from the intergroup study conducted by the Pediatric Oncology Group and the Children’s Cancer Group showed that the addition of ifosfamide and etoposide is a useful adjunct, these have also become the gold standard of treatment for Ewing’s sarcoma .
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PMC11640419
The development of efficacious therapies for cancer and other diseases, characterized by abnormalities in the regulation of cell death, hinges on a comprehensive understanding of the diverse mechanisms through which cells can lose viability and ultimately undergo apoptosis.
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PMC11013014
All molecules exhibit a high absorption regarding their bioavailability score stated as 0.55.
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PMC7229095
CD FortiCHO was powerful media in our recombinant CHO-DG44 cells (Table 2), and was chosen to be tested along CDM1, CDM2, and CDM3, but failed growing in our host cells because of the observation of cell aggregation so had to be halted for this study (data not shown).
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