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OTAR3088
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BioData-CellLine_annotated

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PMC11185260
These observations support the contention that restoration of SMARCB1 via the scL-SMARCB1 nanocomplex could be an effective therapeutic strategy for treating patients with ATRT.
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PMC9429973
L. Ma, Y. Dou, R. Liu, T. Xu, F. Yang, F. Xue, P. Zheng, S. Feng, Y. Guo, H. Shi, B. Deng, X. Ke, K. Hu Department of Adult Lymphoma; Cytology Laboratory, Beijing GoBroad Boren Hospita, Beijing, China Background: CD19 Chimeric Antigen Receptor T cell(CAR-T)therapy has been successfully used to treat refractory/relapse ...
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PMC11258145
To the resulting supernatants, 0.5 cm of trichloroacetic acid (TCA) (0.5%) was added.
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PMC11626627
Wang's research revealed that TWIST1 plays an important role in the invasion and metastasis mechanisms of gastric cancer .
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PMC3888431
is extracted, where results with better confidence values are preferred.
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PMC11665555
Notably, glucose was enriched in GR-OXCT1KO upon gemcitabine treatment but not in 5637GR cells.
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PMC11786767
Ki-67 knockdown alters chromosome structure and delays mitotic progression.
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PMC9019892
All studies were approved by the Hefei Institutes of Physical Science ethics committee, Chinese Academy of Sciences (approval number: DWLL‐2018‐016).
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PMC11707577
Images were acquired every 2 min from A) t = 0 min to F) t = 10 min.
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PMC11461874
a Schematic diagram for identification of DBP-interacting proteins.
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PMC11805741
As the concentration decreases, the cytotoxic effect diminishes, with very low concentrations (75 µg and 37.5 µg) showing negligible impact on cell viability.
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PMC4355729
Cells were respectively harvested, suspended and added to the upper compartment of transwell inserts (8 μm pore size; Corning).
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PMC3274243
The 96-well plates were assayed after 24h using an MTT based in vitro toxicology assay kit (Sigma, Poole, UK) as per the manufacturers’ instructions.
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PMC11240571
This may be due to the amount of PD-L1 expression from 143B tumor cells.
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PMC11607321
To address this, we use only cancer driver events and split genomics into copy number alterations and mutations.
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PMC9429973
We have recently developed a novel, highly modular adapter CAR-T cell (AdCAR) platform capable of targeting multiple antigens via biotin-labeled adapter molecules (AMs) in the context of a specific linker (Seitz et al., 2021).
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PMC9895440
TNFα and IFNβ were not detected but can be found in the source data.
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PMC9429973
Five pts discontinued therapy to undergo stem cell transplantation.
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PMC11766332
Other CDGs are caused by deficiencies in glycogenes controlling different O-linked glycosylation pathways including O-Fuc, O-Glc, O-GlcNAc, O-Xyl, O-GalNAc, and HYL-Gal, as well as glycolipid and glycosylphosphatidylinositol (GPI) anchors .
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PMC9813422
Interestingly, the tethering sites of EBV episomes depend on viral latency type (44).
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PMC10203589
In terms of the mechanism and pathway of FGF18 on lung cancer progression.
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PMC9429973
Methods: Adult (≥18 years) pts with ITP who did not respond to or had relapsed after initial CS therapy, with platelet counts <30×10/L and assessed as needing treatment, were included.
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PMC11747949
CDKN1B, ENO2, Serpin B5 and FKH1–metabolic and tumor suppressor cluster.
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PMC11604830
H‐CSI was selected as the technique of choice due to a series of advantages.
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PMC11594641
The following primers were used: RAB27A (forward, 5′-GTGCTGTGTGGAAACAAGAGT-3′; reverse, 5′-TTTGTCCCATTGGCAGCACT-3′), GAPDH (forward, 5′-CATCATCTCTGCCCCCTCTG-3′; reverse, 5′-TCCACGATACCAAAGTTGTC-3′).
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PMC8708099
Such diseases, including inflammatory bowel disease, are not completely curable, but the specific line of treatment may reduce its symptoms.
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PMC10813895
Regulating ELF5 expression through progesterone may become more complex as women age, and not exactly modeled by mice, likely due to the gradual and persistent shifts in the cellular microenvironment that influence the phenotype of luminal epithelial progenitor cells .
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PMC11634027
Conversely, deletion of the D motif abolished detectable Dachs binding (Fig. 5G).
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PMC11742431
The effects of KVN and K14N proteins on the proliferation of 5637 cells, UMUC‐3 cells, and A375 cells were analyzed using clone formation assays with crystal violet staining.
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PMC7039683
The mouse ortholog of ZNF750 (i.e., ZFP750) is expressed in murine oral epithelium (Richardson et al., 2017), and periderm (Li et al., 2019), and the zebrafish ortholog znf750 is expressed in EVL (Farrell et al., 2018).
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PMC9429973
Summary/Conclusion: Via combined administration of remdesivir and CP, we experienced an overwhelming survival rate in COVID-19 patients with hematological malignancies.
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PMC11643491
However, unlike most studies in this field, our study focuses on the effects at the single-cell level rather than the tissue level, which involves many other physiological considerations.
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PMC6684588
P ≤ 0.01 vs. vehicle-injected muscle by unpaired t-test. (
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PMC11763126
I Western blot analysis showing YTHDF2 levels after treatment with CHX and MG132.
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PMC11469524
While the EGFR-signaling network or the T cell receptor pathway have been quantitatively studied in many contexts, the BCR signaling and its oncogenic variations have so far only gained limited attention.
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PMC10932641
For example, a combination of lncRNA LET, PVT1, PANDAR, PTENP1, and linc00963 identified RCC samples with an area under the receiver operating characteristic (ROC) curve (AUC) of 0.823 (52).
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PMC9596868
Dx1 and Dx2 indicate the individual doses of quercetin and MST-312 required to inhibit a given level of viability x and D1 and D2 indicate the doses of quercetin and MST-312 required to inhibit the same level of viability x in combination, respectively.
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PMC9261184
fuel switching between gas and diesel modes for each of the engines, where the pipework was vented automatically as part of the changeover routing, and testing and maintenance activities where venting was required to isolate short sections of the pipework.
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PMC11742670
Further investigation for interference of Sulfur and Magnesium oxide to cell cycle phases of A-375 and A-431 cell lines respectively was performed as presented in Fig. 13.
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PMC9786247
Of note, a single isolate, Cb30/14, obtained from sheep, induced a significant increase in cytokine gene transcription, e.g., IL-1β and TNF-α.
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PMC11574029
For the lung metastasis model, 1 × 10 luciferase-labeled stably transfected cells were injected into the tail vein of 4–5-week-old female BALB/c nude mice.
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PMC11666785
These techniques have advanced our understanding of biological processes in cellular system.
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PMC7987994
The 100% value represents the mean value of these control measurements.
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PMC11536589
The RNA input for all RT-qPCR analyses was normalized using GAPDH.
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PMC11194678
These data indicate that STAU1 might undergo concentration-dependent LLPS in living cells.
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PMC9118379
For each spectrum, we compared its identified peptides of the two PSMs and the respective search scores.
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PMC11180402
A 5637 cells treated with 20 μM ISO at the indicated time points were analyzed by western blotting for MMP-2, MMP-9, and PTEN; GAPDH served as control.
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PMC9429973
J. Mort, B. Brewer, B. Mautner, S. Dibenedetto, E. Pierce, E. Morse, L. Wells, F. Ghamsari, A. Morris, S. Clark, J. Reid, I. Patel, C. Jackson, M. Perciavalle, B. Yelvington, R. Miller, K. Abernathy, H. Wolfe, S. Locke, J. Zeidner, D. Reed, V. Duong, B. Dholaria, T. LeBlanc, M. Keng, B. Horton, F. El Chaer Hematology a...
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PMC7987994
The first choice is the test for cytotoxicity described in part ISO 10993-5: 2009.
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PMC8357004
DNA hypermethylation plays a major role in tumorigenesis through transcriptional silencing of TSGs.
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PMC9429973
Aims: In this study, we enrolled a total of 9,081 sporadic and familial cases with different MNs from different ethnicities, in which germline and somatic mutations in DDX41 and other major driver genes in AML/MDS were analyzed using next generation sequencing.
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PMC8143558
Thus, a focus on the application of ethnobotany to hand and toilet hygiene is a unique approach on the role plants can play in enhancing community health.
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PMC11718817
The arrest coefficient is the most reliable parameter in linking T cell motility to cytotoxic efficacy, as it determines those phases in which a T cell is immobilized on a target cell .
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PMC11731161
Previous studies have also reported similar findings, indicating that the IC50 value of SEL is higher in U266 cells than in MM.1S cells .
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PMC7294030
Cell-cycle analysis Human lung adenocarcinoma (A549) cells (1 × 10 cells/well) were seeded in 6-well plates for 24 h and then treated with aurisin A (0, 6.25, 10.43 and 16.68 µM) and 5-FU (50 µg/ml).
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PMC9681981
After activating this system, VirR binds to special receptors on DNA, called VirR boxes, and contributes to the regulation of five different C. perfringens genes, including theta, α- (cpa), and β-2 (β2) toxin genes (Chen et al., 2011 ▶; Wang et al., 2012 ▶).
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PMC9221284
They all have the entire last exon (exon3).
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PMC7519871
Figure 8 (A) 3D and (B) 2D poses of BA with B-cell lymphoma 2 Protein (Bcl-2) PDB ID: 4LXD.Figure 9 (A) 3D and (B) 2D poses of BA with B-cell lymphoma-extra large Protein (Bcl-xL) PDB ID: 4TUH.Figure 10 (A) 3D and (B) 2D poses of WDL with B-cell lymphoma 2 Protein (Bcl-2) PDB ID: 4LXD.Figure 11 (A) 3D and (B) 2D poses ...
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PMC11306331
There is still much to be done to decipher the code that links condensate and solubilizer.
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PMC6889484
A3G-D128K expression in T cell lines CEM, CEMSS, and PM1 potently inhibited spreading infection of several HIV-1 subtypes by C-to-U deamination leading to lethal G-to-A hypermutation and inhibition of reverse transcription.
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PMC3681794
A, Stable HOS clones expressing shRNAi to HIF-1α (C5) and firefly luciferase as a control (L4) were incubated in normoxia or hypoxia for 24 hours before exposure to cisplatin (0–150 µM), doxorubicin (0–2.5 µM) or etoposide (0–50 µM) for 1 hour.
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PMC11794568
An important implication of this study is that CRIP1 may serve as a novel target for melanoma treatment.
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PMC11705862
Dotplots for all neurons analysed were included and color coded by case number, with the estimate of the fixed effect as the slope, shown in (H) for IRIS-1 and (J) for IRIS-2 In diabetic patients, inadequate glucose control is linked to decreased cognitive function , as high serum glycated hemoglobin (HbA1c) levels are...
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PMC11587606
Diminished PKCζ protein levels in the cytosol result in a disruption of epithelial apicobasal polarity and TJ/AJ barrier.
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PMC8806312
Furthermore, high risk markedly related to the infiltration of several immune cell types, including M2 macrophages, naïve CD4 T cells, and CD8 T cells.
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PMC11583690
Next, a DTX concentration of 1.0 mg/mL was chosen to investigate loading capacity at drug-to-nanomaterial mass ratios of 1:1, 1:2, 1:3, 1:4, and 1:5.
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PMC11694346
A431 cells were incubated with BT-DNBS (10 μM) for 120 minutes under two conditions: in the absence of NEM (Fig. 9(a)) and in the presence of NEM (50 μM pre-treatment for 60 minutes) (Fig. 9(b)).
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PMC11470999
There have been several successful examples in this area.
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PMC9812014
Aside from these, other manzamine-based alkaloids have considerable anti-HIV efficacy.
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PMC8526701
Our findings indicated that GSK602 treatment promotes the upregulation of PUMA (Fig. 3A and B).
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PMC11740508
As expected from their ability to accurately repair DNA, the HRR proficient M231 cells maintained a relatively low, tonic level of p-H2A.X foci at all timepoints and tratments, only briefly rising over 10 per cell at 48 h with Tala + Deci (Fig. 2A, blue, ~ 12 per nucleus average).
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PMC5415764
In addition, we adopted the combination of single PTX/iRGD LPN and free TET (P/iRGD LPN+T) to evaluate the advantages of co-loading drugs.
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PMC8658661
In Table 1, we summarize the characteristics of the top five most studied hepatic tumor cell lines.
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PMC10748106
Additionally, Euphrasin and Campsinol exhibited hydrophilic properties like those of Genipin, while Artselaenin A and B displayed greater hydrophobicity than the others.
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PMC6892818
b–f ACHN, 786-O and A-704 cells were treated with mCD40L in the absence (vehicle control—denoted ‘Control’) or presence of the indicated concentration (12.5, 25 and 50 μM) of JNK inhibitor SP600125 (b), p38 inhibitor SB202190 (c), AP-1 inhibitor NDGA (d), MEK/ERK inhibitor U0126 (e) and NF-κB inhibitor (PDTC).
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PMC11055323
A total of 200µL EdU (10 µM) reagent (Beyotime, C0078S) was added to each well and incubated for 6 h to label the cells.
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PMC8481254
Here we found that OGT, the only known endogenous enzyme that catalyzes O-GlcNAcylation , was significantly upregulated in liver cancer tissues compared to adjacent normal tissues.
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PMC11612315
f Mean normalized calcium influx in CHO K1 cells expressing human TRPV1.
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PMC9341513
Figure 5 shows results from simulations using Z-138 epigenomic data (again obtained from BLUEPRINT [Stunnenberg et al. 2016] and ENCODE [The ENCODE Project Consortium 2012]).
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PMC11753949
We reveal a dual role of synaptopodin in generating actin bundles and in linking them to the ER.
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PMC11012313
GAPDH was used as an endogenous control for each experimental group in order to calculate the relative gene expression of samples.
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PMC11012313
Following subsequent washes, cells were stained with PE-conjugated HIF-1α antibody (Biolegend), anti-4E-BP1 (Cell Signaling Technologies, Danvers, MA), or anti-Von Hippel Lindau (VHL) antibody (Thermo Fisher Scientific).
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PMC10376064
For full-blown concentration-effect curves, dilution series of both DMF and DMS-SG were generated in a concentration range between 0.05 µM and 100 µM. DMS-SG was generated according to a previously established protocol by an equimolar mixture of DMF and glutathione (incubation: 30 min) and subsequent generation of the ...
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PMC11429241
In contrast, 14,000 cells per well resulted in even scaffold coverage, ensuring structured 3D cell culture formation.
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PMC9429973
To analyze the correlation between myocardial injury and myocardial iron content.
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PMC9429973
Most pts (62%) had primary MF, and all pts had received ≥3 mo of prior RUX; the most common reason for RUX D/C was loss of response/Tx failure (41%).
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PMC11768927
Co-treatment with the JAK1/2 inhibitor ruxolitinib reversed this antiviral response in vitro and enhanced the efficacy of oncolytic virus therapy in vivo, without significant toxicity.
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PMC9429973
Methods: NX-5948-301 is a first-in-human, dose escalation (Phase 1a) and cohort expansion (Phase 1b) study designed to evaluate the safety, tolerability, and preliminary efficacy of NX-5948 in adult patients with relapsed and refractory B-cell malignancies.
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PMC11306331
Fraction of cells where condensate dissolution was observed is indicated for each MBP level.
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PMC9884169
However, whether MCT4 affects ferroptosis and autophagy in bladder cancer cells remains unclear.
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PMC9065483
Together, both our ex vivo and in vivo data support that gefitinib can reverse the effects of vanadate in combination with VSV in animal models.
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PMC11786600
Furthermore, P < 0.05 for gauze/PED0 group comparisons, gauze/PED2 group comparisons, and gauze/PED4 group comparisons are denoted by # (well signs), ∆ (triangles), and ◇ (diamonds), respectively.
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PMC11424574
Our previously published results show that MTA2 serves as a prognostic factor for human cervical cancer , renal cancer , and hepatocellular carcinoma ; however, less is known about the clinical significance of MTA2 in human osteosarcoma patients.
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PMC11496491
Detection of differentially expressed genes and analysis of corresponding signaling pathways in biological processes can provide a theoretical basis for the mechanistic study of biological processes.
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PMC10142392
Therapeutic polymers can also be used to specifically target certain cells or tissues, depending on their composition and size.
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PMC11001582
e, qPCR analysis of TGFB1 transcript levels normalized to GAPDH at DIV 5 (left panel) and DIV 7 (right panel) in (GR)50, or GFP-treated iNeurons.
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PMC9429973
Aims: To evaluate and confirm that the previously established in vitro and ex vivo efficacy and safety profiles of MP0533 are also observed in an in vivo human PBMC xenograft mouse model.
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PMC11655498
Various transcriptional activators and repressors are demonstrated to bind to BZLF1 and BRLF1, whose expression then determines the state of EBV infection (Spitz and Furlong, 2012; Lambert et al., 2018; Pope and Medzhitov, 2018).
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PMC11711127
This points to the intrinsic mechanism of T cell ignorance, where the affinity of CAR to Ag or Ag abundance are too low to elicit T cell activation.
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PMC11678368
In colon cancer cell lines, specifically HT-29, the trans-[PtCl2(5ClL)2] (IC50 = 6.39 ± 1.07 µM) also demonstrated better antiproliferative activity than the unsubstituted trans-[PtCl2(7AI3CAH)2], which was less active against the related LoVo line (IC50 = 8.1 ± 1.5 µM) .
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