OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9848491	The disorderly and rapid growth of cancer cells and the hypoxic and malnourished tumor environment lead to ER stress.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "disorderly", "and", "rapid...
PMC11629143	mAb titers of cell pools stably expressing dCas9 alone at weeks 0 and 10, dCas9‐TET1, dCas9‐p300 and both dCas9‐p300 and dCas9‐TET1 at week 10. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9516447	To test whether these processes are involved, A427, HCT116, and PANC-1 cells were transfected with siCtrl or si78 followed by treatment of DMSO, proteasome inhibitors (MG132) or autophagy inhibitor (3-MA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", ...
PMC11265931	All cell lines were seeded into 96-well plates at a concentration of 5 × 103 cell/well and after one day cells were treated with different concentrations of garlic exosomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9895440	The following formula was used to calculate the glucose and FAO/AAO dependence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "following", "formula", "was", "used", "to", "calculate", "the", "glucose"...
PMC11599565	Figure 5, Panel A reflects the expression of key transcription factors crucial for neuronal development, e.g. SOX2 and HES1 TFs, both involved in the generation and maintenance of progenitor and stem cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11629461	Note the bright fluorescence in transfected NOX5‐CHO‐K1 cells (A, right), but no fluorescence in un‐transfected parental CHO‐K1 cells (A, left) (CTL1, control).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", ...
PMC11290772	Utilizing the CCK-8 assay, we observed that following 24 h of co-culturing, ROBO1-NK cells efficiently lysed the primary tumor cells from sample #01, #02, #03 and #04, resulting in lysis rates of 26, 23, 52 and 27%, respectively, while PBMC-NK cells exhibited lysis rates of 36, 78, 61 and 75% (Figure 3D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11513571	Mann Whitney U-test was used to compare between different stimulants with unstimulated cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mann", "Whitney", "U-test", "was", "used", "to", "compare", "between", ...
PMC11555465	Bladder cancer 5637 cells were seeded in 96-well plates at a density of 1×10 cells/well and treated with the culture supernatant of T. gondii tachyzoites for 24, 48 and 72 h at 37°C.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11577421	However, regarding the glycocalyx as a mere passive physical barrier against the cell entry of macromolecules, pathogens, or NPs would be inaccurate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11321678	one‐way ANOVA tests and subsequent Dunnett tests were used for comparisons within multiple groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "one‐way", "ANOVA", "tests", "and", "subsequent", "Dunnett", "tests", ...
PMC10944868	COL, colchicine.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "COL", ",", "colchicine", "." ] } ]
PMC11306019	Fifteen dietary polyphenol used in this study consist of gallic acid (GA), protocatechuic acid (PA), 3,4-dihydroxyphenylpropionic acid (DPA), caffeic acid (CA), (+)‐catechin (CC), (−)‐epicatechin (EC), hydroxytyrosol (HT), 3,4-dihydroxyphenylacetic acid (DAA), gallic acid ethyl ester (GE), (−)‐gallocatechin (GC), (−)‐e...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9895440	Healthy donor human CD8 T cells are stimulated ex vivo and lentivirally transduced with an anti-human-CD19(FMC63vH)-CD28-CD3zeta-T2A-copGFP CAR construct and electroporated with Cas9-crRNA-tracrRNA complexes to generate SNX9 KO cells and intergenic controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637276	To identify the hits, we calculated the first derivative of the curve of normalised values within the population tested, excluding controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", ...
PMC11461874	DBP is a member of proline- and acidic amino acid-rich basic leucine zipper (PAR-bZIP) protein family, and is rhythmically transcribed via E-box in many tissues and in cultured cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9019892	Effects of nintedanib on human GIST cell lines and human primary GIST cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Effects", "of", "nintedanib", "on", "human", "GIST", "cell", "li...
PMC11772449	A-D: PFD combined with Sora can down-regulate the level of autophagy in HCC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A-D", ":", "PFD", "combined", "with", "Sora", "can", ...
PMC10852540	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test was applied to determine the effect of RA and DOX on the proliferation of OVCAR3 and HaCaT cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], ...
PMC11487720	Red arrows indicate the time of initiation of nuclear bubble formation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Red", "arrows", "indicate", "the", "time", "of", "initiation", "of", "nuclear", "bubb...
PMC11190238	During TGF-β induced-EMT in NMuMG cells, the expression of E-cadherin was mediated by DNA looping between the transcription start site (TSS) of Cdh1 to the enhancers bound by GRHL2 and HNFα.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6222635	The signals 4.04 and 3.43 were from the C2 and C3 position hydrogen of (1→4)-linked mannose and (1→4)-linked glucose.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "signals", "4.04", "and", ...
PMC11388384	The ATV(+)/Espin cell line was generated using Lipofectamine LTX and piggyBAC transposase based on a plasmid (pGS202: TRE-anti-GFPnb)-2A-Espin-sfGFP; EF1a-TetON3G) described previously (12) in established SHH sender cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11139449	Integrating robust strategies with the CRISPR-Cas9 system enables its application in CHO cell engineering.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Integrating", "robust", "strategies", "with", "the", "CRISPR-Cas9",...
PMC11760643	This study provides the most comprehensive single analysis of P2X7 expression on human blood leukocyte subsets to date.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "provides", "the", "mo...
PMC9429973	Correlation analysis shows that there is a good correlation between the T1/2 of the modified one-chamber model and the results of WinNolin’s calculation in all three time periods, but the correlation/consistency is the highest in the period of 9h~48h (see fig 1); 4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10873328	The promoter region of TGFBI (specifically -155- -145 “GCACGGGCCG”) was predicted as the binding motif of HIF-2α, indicating that HIF-2α may directly contribute to the high expression of TGFBI (Fig. 2g).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11290772	Additionally, it is crucial to acknowledge that ROBO1 represents a novel potential target identified in this study, warranting further investigation in future clinical studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	To assess the relationship between the variables, the Spearman correlation coefficient (r) was calculated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "assess", "the", "relationship", "between", ...
PMC10798140	Several derivatives of 4-aminoquinoline have been approved in therapy or are undergoing clinical trial for the treatment of cancer (Fig. 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several...
PMC11461025	We therefore decided to examine the phosphorylation status of ERK (phospho-ERK) in cells treated with isoginkgetin for 24 hours compared to control cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11757131	This is consistent with the results of ATP synthesis in cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "consistent", "with", "the", "results", "of", "ATP", "synthesis", "in", ...
PMC11519788	Stattic (20 μM, HY-13818; MedChemExpress, USA), RS 504393 (2 μM, HY-15418; MedChemExpress), IL-6 (50 ng/ml, #200-6; PeproTech, USA) and neutralizing IL-6 antibody (100 ng/ml, MAB2061; R&D systems, USA) (Table S3) were used for cell function assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11055510	The PBS was removed and 100 µl permeabilization solution was added (0.5% TritonX-100 in PBS) per well and incubated for 10 min at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11791432	ANXA1 has been reported to be aberrantly expressed in breast cancer , and it was observed to facilitate tumor proliferation and metastasis in laryngeal cancer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11387401	Number of detected RNA interactors for all HIV-1 proteins for each of the four performed assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Number", "of", "detected", "RNA", "interactors", "for"...
PMC9429973	More experiments are needed to apply cell-free DNA for clinical use in patients with FL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "More", "experiments", "are", "needed", "to", "apply", "cell...
PMC9429973	The gene expression upon the drug treatment is evaluated by qPCR and western blot.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gene", "expression", "upon", "the", "drug", "treatment", ...
PMC9429973	Bone marrow (BM) of AA pts was collected and cryopreserved before ATG administration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bone", "marrow", "(", "BM", ")", "of", "AA", "pts", ...
PMC8270637	It is reported that the PD-1/PD-L1 pathway can mediate the apoptosis of T cells (21, 22).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "reported", "that", ...
PMC10882807	qRT-PCR analyzed the expression of hsa_circ_0005397 in cell lines. (*	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "qRT-PCR", "analyzed", "the", "expression", "of", "hsa_circ_0005397", "in", "cell", "lines",...
PMC10203589	Treatment options should be judged according to the development of the disease, including surgery, lymph node dissection, and adjuvant radiotherapy and chemotherapy (138–141).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: A partitioned-survival model was used to extrapolate overall survival, progression-free survival, quality-adjusted survival and healthcare costs of R/R MCL patients over a lifetime horizon, assuming that patients who had not relapsed within 5 years experienced long-term remission.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10547921	Compound 77 has an IC50 in the range of 0.1–2 pmol/L for six human tumor cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compound", "77", "has", "an", "IC50", "in",...
PMC8750422	Our results elucidate the mechanism for the oncogenic function of GPR87 in the progression and metastasis of lung adenocarcinoma, and suggest strategies that may improve therapeutic outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10808409	They are widely used in the preparation of PM due to their potential solubilizing effect, and their inhibition of P-glycoprotein (P-gp) efflux, in addition to their increased circulation time.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8348645	It is a shrub commonly known as the grapevine: it is one of the most economically important fruit crops, having about 60 different species in the genus Vitis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	With the rapid progress of multiple myeloma treatment, including the application of proteasome inhibitors and immunomodulatory drugs and the promotion of autologous stem cell transplantation (ASCT), the prognosis of MM patients has been greatly improved.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10142392	The self-assembly of these miktoarms exhibited a very low CMC, indicating high colloidal stability in aqueous solution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "self-assembly", "of", "these", ...
PMC11803918	Liposomes encapsulated with Ce6 were detected at APC channel and γδ-T exosomes stained with carboxyfluorescein succinimidyl ester (CFSE) were detected at the FITC channel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Group A: N =53 starts treatment between Sep/01/2018 and Aug/31/19 with a combination of ≥2 drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Group", "A", ":", "N", "=", "53"...
PMC11623887	NS1, 11kDa, and 7.5kDa proteins are nonstructural, and VP1 and VP2 are capsid proteins encoded by the B19V genome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NS1", ",", ...
PMC11640419	It has been demonstrated that these pathways operate in parallel and can overlap .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been", "demonstrated", "that", "these", "pathways", "operate",...
PMC11726848	On the other hand, massive DNA damage, induced under HDR irradiation, triggers the halt of mitosis, providing time for the cell to repair before division, and such recovery attempts lead to greater radiosensitivity .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The c.-118C>T variant was already published by several authors and was always associated with thrombocytopenia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "c.-118C", ">", "T", "variant", "was"...
PMC9429973	Biomarkers studies may further elucidate patients who are more likely to respond to this treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Biomarkers", "studies", "may", "further", "elucidate", "patients"...
PMC9436459	From the structural characteristics of endo- and exo-adducts in the Diels–Alder reaction, the trans–trans type adducts have been found to be exo-addition products, while the cis–trans type adducts are attributed to endo-addition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7925574	Additionally, in Supplementary Figure S2a, the graphs for ‘E1A’ and ‘E1B’ are reversed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "in", "Supple...
PMC9429973	Seven of ten MDS patients who transformed to AML were identified with lately acquired subclones harboring FLT3 or NF1, mutations involving in signaling pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10587429	In addition to the NSG strains, NOG (NOD.Cg-PrkdcscidIL2rgtm1Sug), BRG (Balb/c Rag2-/-IL2rg-/-) and recently developed NPG (NOD-PrkdcscidIL2rgnull) and NCG (NOD-Prkdcem26IL2rgem26Nju) are popular strains most frequently used in the models for recapitulation of human immune system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11725127	ns: no significance.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "ns", ":", "no", "significance", "." ] } ]
PMC11055323	In comparison to condensate-deficient mutant SS18(YA)-SSX control, the expression of SS18-SSX in BJ cells attenuates the occupancy of cohesin but enhances the CTCF binding moderately (Supplementary Fig. 12a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787651	To take advantage of this increase in speed, we developed an ultrafast microflow gradient for the separation of histone peptides.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "take", "adv...
PMC11489351	The data from RPE cells showed pH-dependent expression of LDHA protein, with significantly increased expression at high pHi compared to control and significantly decreased expression at low pHi compared to high pHi (Fig. S7, C and D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711063	ZG16B mRNA was transcribed to cDNA from HME‐hTert total RNA samples by reverse transcription.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ZG16B", "mRNA", "was", "transcribed", "to", "cDNA", "from", "HME...
PMC11679892	Samples were loaded as 40 μL and then 10 μL of anti-8-OHDG antibody was added.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Samples", "were", "loaded", "as", "40", "μL", "and", ...
PMC8427838	Previous studies have shown that moesin connects major cytoskeletal structures to the plasma membrane and regulates cell polarity, cell adhesion and microtubule dynamics .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11435360	The mere presence of CSE, CBS, and 3-MST had not been reported in human BC tissue until 2016 when Gai et al. demonstrated H2S metabolism dysregulation in BC by revealing low H2S expression and productivity in healthy bladder tissues, moderate expression and productivity in NMIBC tissues, and high expression and product...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9621239	Annexin V-PE and 7-Aminoactinomycin D (7-AAD) (559763, BD Biosciences, USA) were used to label dead cells, following the manufacturer's instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11666785	If the centroids are found to lie within the theoretically estimated diffraction-limited spot (r ~ 1.2λ/2NA), then the respective Gaussians are correlated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8956657	We next examined the effect of a MERS-CoV ORF4b His to Ala (H26A) mutation within the minor site and found that the structure was almost identical to the MERS-CoV WT ORF4b NLS (Fig. 3C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11342785	D, cluster disassembly kinetics in cells across different TPPP variants.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", ",", "cluster", "disassembly", "kinetics", "in", "cells", "across", "different", ...
PMC7823217	Pancreatic adenocarcinoma is the second most lethal cancer in the world.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pancreatic", "adenocarcinoma", "is", "the", "second", "most", "lethal", "cancer", "in", ...
PMC9960565	After the coordination of the PAMAM dendrimer to cisplatin in a bidentate form, the cisplatin band shifted from 203 to 247 nm, 242 nm, and 241 nm for G1.5COO(Pt(NH3)2)8, G2.5COO(Pt(NH3)2)16, and G3.5COO(Pt(NH3)2)32, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767817	DKK4 proteins can inhibit the activity of the Wnt/β-catenin signaling pathway , which involves diverse physiological processes such as proliferation, differentiation, apoptosis, migration, invasion, and tissue homeostasis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6799808	Similar data were obtained in one-solution assays (Fig. 1c, d).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar", "data", "were", "obtained", "in", "one-solution", "assays", "(", ...
PMC11739484	Mechanistically, MMP overexpression may contribute to resistance through remodeling of the extracellular matrix, which can limit drug penetration, or by activating survival signaling pathways that confer resilience against therapeutic agents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5874706	All drug-loaded nanoparticles caused more cytotoxicity against A-427 cells than THN7 alone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "All", "drug-loaded", "nanoparticles", "caused", "more", "cytotoxicity", "against", ...
PMC7553912	To date, there are no mouse models for Randall’s plaque, except for a mutant mouse lacking ABCC6 (ATP-binding cassette sub-family C member 6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11638255	a Overrepresentation analysis of pathways relatively enriched in TEPA-treated immune cell clusters compared to control, presented as nodes with associated genes as branches using single-cell RNA sequencing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11755519	The tube formation and migratory capacity of HLECs were markedly increased after incubation with EVs secreted by UM-UC-3 and T24 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "The", ...
PMC7185206	This suggests that this resistance is mediated by ADAM10 and/or ADAM17 and requires PD-L1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "suggests", "that", "this", "resistance", "is", "mediated", ...
PMC9712534	Only a small fraction of the molecules transiently reside in their sites of action, typically on the order of seconds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Only", "a", "smal...
PMC9424261	E mRNA levels of HERPUD1 in tumors were analyzed by qPCR assay after drug treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", "mRNA", "levels", "of", "HERPUD1", "in", "tumors", ...
PMC11657744	Nuclei were stained with 4’,6-diamidino-2-phenylindole (DAPI) (Invitrogen).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nuclei", "were", "stained", "with", "4’,6-diamidino-2-phenylindole", "(", "DAPI", ")", "(",...
PMC11699042	An expansion of these analyses by exploring non-synonymous SNPs that affected the coding sequence and splicing regions for the 11 different A-673 strains (including two A-673 with genetic modifications) using Illumina Global Screening Arrays (GSA) revealed that 98.9% were shared by all strains (Fig. 1c), which drastica...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC11694625	Cell apoptosis and ROS intensity were detected by a flow cytometry (Beckman coulter CytoFLEX, America).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "apoptosis", "and", "ROS", "int...
PMC9429973	Methods: To study the effect of the ERCC6L2 and SDBS germline mutations on cellular metabolism in isolation from the effect of accumulating somatic mutations in the bone marrow, we examined patient-derived skin fibroblasts (ERCC6L2 syndrome, n=2; SDS, n=2) and healthy controls (n=2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11082662	All patients with ovarian cancer had primary cancer and were aged between 51 and 69 years, with an average age of 58.95±6.83 years.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11615743	To synthesize the D‐DNA/L‐DNA chimera, 1000 Å CPG powder (20 g) was weighed and placed on a DNA synthesis column, with the two ends of the synthesis column fixed with plug plates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Median OS was longer with gilteritinib (9.0 mo) vs SC (4.7 mo; HR 0.549 [95% CI: 0.379, 0.795]; P=0.00126); 1-year survival rate was 33.3% and 23.2%, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	First interim data will be made available by the end of 2022.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "First", "interim", "data", "will", "be", "made", "available", "by", "the", ...
PMC9429973	The median viability was 96% (92-99.7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "viability", "was", "96", "%", "(", "92", "-", "99.7", ")", ...
PMC6643347	In 1988, during the International Humic Substances Society meeting, it was suggested that humic substances might offer significant promise as drugs for treating diverse diseases .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11765243	Single-cell suspensions were incubated for 15 min with 10% heat-inactivated normal mouse serum in ice-cold staining buffer (PBS with 2% heat-inactivated FBS) to block Fc receptors and then with the indicated labelled antibodies to detect cell-surface molecules; after extensive washing, they were analyzed by flow cytome...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11352746	Fixating cells can introduce artifacts and obscure cellular behaviors, potentially confounding experimental results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fixating", "cells", "can", "introduce", "artifacts", "and", "obscure",...
PMC11628904	In the larval stage, zebrafish have a stratified epithelium composed of two layers of keratinocytes and a collagen‐rich dermis, providing an anatomically simplified model to investigate cellular behaviour in response to burn injury.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5308810	To design new and more effective treatments, it is essential to understand how chemotherapy induces drug resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "design", "new", "and", "more", ...
PMC9688728	Each sample (1 µL) was injected through the glass liner (Restek, Bellefonte, PA, USA) under split mode (50:1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9848491

The disorderly and rapid growth of cancer cells and the hypoxic and malnourished tumor environment lead to ER stress.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "disorderly", "and", "rapid...

PMC11629143

mAb titers of cell pools stably expressing dCas9 alone at weeks 0 and 10, dCas9‐TET1, dCas9‐p300 and both dCas9‐p300 and dCas9‐TET1 at week 10. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9516447

To test whether these processes are involved, A427, HCT116, and PANC-1 cells were transfected with siCtrl or si78 followed by treatment of DMSO, proteasome inhibitors (MG132) or autophagy inhibitor (3-MA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", ...

PMC11265931

All cell lines were seeded into 96-well plates at a concentration of 5 × 103 cell/well and after one day cells were treated with different concentrations of garlic exosomes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9895440

The following formula was used to calculate the glucose and FAO/AAO dependence.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "following", "formula", "was", "used", "to", "calculate", "the", "glucose"...

PMC11599565

Figure 5, Panel A reflects the expression of key transcription factors crucial for neuronal development, e.g. SOX2 and HES1 TFs, both involved in the generation and maintenance of progenitor and stem cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11629461

Note the bright fluorescence in transfected NOX5‐CHO‐K1 cells (A, right), but no fluorescence in un‐transfected parental CHO‐K1 cells (A, left) (CTL1, control).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", ...

PMC11290772

Utilizing the CCK-8 assay, we observed that following 24 h of co-culturing, ROBO1-NK cells efficiently lysed the primary tumor cells from sample #01, #02, #03 and #04, resulting in lysis rates of 26, 23, 52 and 27%, respectively, while PBMC-NK cells exhibited lysis rates of 36, 78, 61 and 75% (Figure 3D).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11513571

Mann Whitney U-test was used to compare between different stimulants with unstimulated cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mann", "Whitney", "U-test", "was", "used", "to", "compare", "between", ...

PMC11555465

Bladder cancer 5637 cells were seeded in 96-well plates at a density of 1×10 cells/well and treated with the culture supernatant of T. gondii tachyzoites for 24, 48 and 72 h at 37°C.

[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11577421

However, regarding the glycocalyx as a mere passive physical barrier against the cell entry of macromolecules, pathogens, or NPs would be inaccurate.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11321678

one‐way ANOVA tests and subsequent Dunnett tests were used for comparisons within multiple groups.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "one‐way", "ANOVA", "tests", "and", "subsequent", "Dunnett", "tests", ...

PMC10944868

COL, colchicine.

[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "COL", ",", "colchicine", "." ] } ]

PMC11306019

Fifteen dietary polyphenol used in this study consist of gallic acid (GA), protocatechuic acid (PA), 3,4-dihydroxyphenylpropionic acid (DPA), caffeic acid (CA), (+)‐catechin (CC), (−)‐epicatechin (EC), hydroxytyrosol (HT), 3,4-dihydroxyphenylacetic acid (DAA), gallic acid ethyl ester (GE), (−)‐gallocatechin (GC), (−)‐e...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9895440

Healthy donor human CD8 T cells are stimulated ex vivo and lentivirally transduced with an anti-human-CD19(FMC63vH)-CD28-CD3zeta-T2A-copGFP CAR construct and electroporated with Cas9-crRNA-tracrRNA complexes to generate SNX9 KO cells and intergenic controls.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11637276

To identify the hits, we calculated the first derivative of the curve of normalised values within the population tested, excluding controls.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", ...

PMC11461874

DBP is a member of proline- and acidic amino acid-rich basic leucine zipper (PAR-bZIP) protein family, and is rhythmically transcribed via E-box in many tissues and in cultured cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9019892

Effects of nintedanib on human GIST cell lines and human primary GIST cells. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Effects", "of", "nintedanib", "on", "human", "GIST", "cell", "li...

PMC11772449

A-D: PFD combined with Sora can down-regulate the level of autophagy in HCC cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A-D", ":", "PFD", "combined", "with", "Sora", "can", ...

PMC10852540

3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test was applied to determine the effect of RA and DOX on the proliferation of OVCAR3 and HaCaT cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], ...

PMC11487720

Red arrows indicate the time of initiation of nuclear bubble formation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Red", "arrows", "indicate", "the", "time", "of", "initiation", "of", "nuclear", "bubb...

PMC11190238

During TGF-β induced-EMT in NMuMG cells, the expression of E-cadherin was mediated by DNA looping between the transcription start site (TSS) of Cdh1 to the enhancers bound by GRHL2 and HNFα.

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PMC6222635

The signals 4.04 and 3.43 were from the C2 and C3 position hydrogen of (1→4)-linked mannose and (1→4)-linked glucose.

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PMC11388384

The ATV(+)/Espin cell line was generated using Lipofectamine LTX and piggyBAC transposase based on a plasmid (pGS202: TRE-anti-GFPnb)-2A-Espin-sfGFP; EF1a-TetON3G) described previously (12) in established SHH sender cell lines.

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PMC11139449

Integrating robust strategies with the CRISPR-Cas9 system enables its application in CHO cell engineering.

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PMC11760643

This study provides the most comprehensive single analysis of P2X7 expression on human blood leukocyte subsets to date.

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PMC9429973

Correlation analysis shows that there is a good correlation between the T1/2 of the modified one-chamber model and the results of WinNolin’s calculation in all three time periods, but the correlation/consistency is the highest in the period of 9h~48h (see fig 1); 4.

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PMC10873328

The promoter region of TGFBI (specifically -155- -145 “GCACGGGCCG”) was predicted as the binding motif of HIF-2α, indicating that HIF-2α may directly contribute to the high expression of TGFBI (Fig. 2g).

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PMC11290772

Additionally, it is crucial to acknowledge that ROBO1 represents a novel potential target identified in this study, warranting further investigation in future clinical studies.

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PMC9429973

To assess the relationship between the variables, the Spearman correlation coefficient (r) was calculated.

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PMC10798140

Several derivatives of 4-aminoquinoline have been approved in therapy or are undergoing clinical trial for the treatment of cancer (Fig. 1).

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PMC11461025

We therefore decided to examine the phosphorylation status of ERK (phospho-ERK) in cells treated with isoginkgetin for 24 hours compared to control cells.

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PMC11757131

This is consistent with the results of ATP synthesis in cells.

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PMC11519788

Stattic (20 μM, HY-13818; MedChemExpress, USA), RS 504393 (2 μM, HY-15418; MedChemExpress), IL-6 (50 ng/ml, #200-6; PeproTech, USA) and neutralizing IL-6 antibody (100 ng/ml, MAB2061; R&D systems, USA) (Table S3) were used for cell function assays.

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PMC11055510

The PBS was removed and 100 µl permeabilization solution was added (0.5% TritonX-100 in PBS) per well and incubated for 10 min at room temperature.

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PMC11791432

ANXA1 has been reported to be aberrantly expressed in breast cancer , and it was observed to facilitate tumor proliferation and metastasis in laryngeal cancer .

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PMC11387401

Number of detected RNA interactors for all HIV-1 proteins for each of the four performed assays.

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PMC9429973

More experiments are needed to apply cell-free DNA for clinical use in patients with FL.

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PMC9429973

The gene expression upon the drug treatment is evaluated by qPCR and western blot.

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PMC9429973

Bone marrow (BM) of AA pts was collected and cryopreserved before ATG administration.

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PMC8270637

It is reported that the PD-1/PD-L1 pathway can mediate the apoptosis of T cells (21, 22).

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PMC10882807

qRT-PCR analyzed the expression of hsa_circ_0005397 in cell lines. (*

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PMC10203589

Treatment options should be judged according to the development of the disease, including surgery, lymph node dissection, and adjuvant radiotherapy and chemotherapy (138–141).

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PMC9429973

Methods: A partitioned-survival model was used to extrapolate overall survival, progression-free survival, quality-adjusted survival and healthcare costs of R/R MCL patients over a lifetime horizon, assuming that patients who had not relapsed within 5 years experienced long-term remission.

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PMC10547921

Compound 77 has an IC50 in the range of 0.1–2 pmol/L for six human tumor cell lines.

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PMC8750422

Our results elucidate the mechanism for the oncogenic function of GPR87 in the progression and metastasis of lung adenocarcinoma, and suggest strategies that may improve therapeutic outcomes.

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PMC10808409

They are widely used in the preparation of PM due to their potential solubilizing effect, and their inhibition of P-glycoprotein (P-gp) efflux, in addition to their increased circulation time.

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PMC8348645

It is a shrub commonly known as the grapevine: it is one of the most economically important fruit crops, having about 60 different species in the genus Vitis .

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PMC9429973

With the rapid progress of multiple myeloma treatment, including the application of proteasome inhibitors and immunomodulatory drugs and the promotion of autologous stem cell transplantation (ASCT), the prognosis of MM patients has been greatly improved.

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PMC10142392

The self-assembly of these miktoarms exhibited a very low CMC, indicating high colloidal stability in aqueous solution.

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PMC11803918

Liposomes encapsulated with Ce6 were detected at APC channel and γδ-T exosomes stained with carboxyfluorescein succinimidyl ester (CFSE) were detected at the FITC channel.

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PMC9429973

Group A: N =53 starts treatment between Sep/01/2018 and Aug/31/19 with a combination of ≥2 drugs.

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PMC11623887

NS1, 11kDa, and 7.5kDa proteins are nonstructural, and VP1 and VP2 are capsid proteins encoded by the B19V genome.

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PMC11640419

It has been demonstrated that these pathways operate in parallel and can overlap .

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PMC11726848

On the other hand, massive DNA damage, induced under HDR irradiation, triggers the halt of mitosis, providing time for the cell to repair before division, and such recovery attempts lead to greater radiosensitivity .

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PMC9429973

The c.-118C>T variant was already published by several authors and was always associated with thrombocytopenia.

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PMC9429973

Biomarkers studies may further elucidate patients who are more likely to respond to this treatment.

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PMC9436459

From the structural characteristics of endo- and exo-adducts in the Diels–Alder reaction, the trans–trans type adducts have been found to be exo-addition products, while the cis–trans type adducts are attributed to endo-addition.

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PMC7925574

Additionally, in Supplementary Figure S2a, the graphs for ‘E1A’ and ‘E1B’ are reversed.

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PMC9429973

Seven of ten MDS patients who transformed to AML were identified with lately acquired subclones harboring FLT3 or NF1, mutations involving in signaling pathway.

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PMC10587429

In addition to the NSG strains, NOG (NOD.Cg-PrkdcscidIL2rgtm1Sug), BRG (Balb/c Rag2-/-IL2rg-/-) and recently developed NPG (NOD-PrkdcscidIL2rgnull) and NCG (NOD-Prkdcem26IL2rgem26Nju) are popular strains most frequently used in the models for recapitulation of human immune system.

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PMC11725127

ns: no significance.

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PMC11055323

In comparison to condensate-deficient mutant SS18(YA)-SSX control, the expression of SS18-SSX in BJ cells attenuates the occupancy of cohesin but enhances the CTCF binding moderately (Supplementary Fig. 12a).

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PMC11787651

To take advantage of this increase in speed, we developed an ultrafast microflow gradient for the separation of histone peptides.

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PMC11489351

The data from RPE cells showed pH-dependent expression of LDHA protein, with significantly increased expression at high pHi compared to control and significantly decreased expression at low pHi compared to high pHi (Fig. S7, C and D).

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PMC11711063

ZG16B mRNA was transcribed to cDNA from HME‐hTert total RNA samples by reverse transcription.

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PMC11679892

Samples were loaded as 40 μL and then 10 μL of anti-8-OHDG antibody was added.

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PMC8427838

Previous studies have shown that moesin connects major cytoskeletal structures to the plasma membrane and regulates cell polarity, cell adhesion and microtubule dynamics .

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PMC11435360

The mere presence of CSE, CBS, and 3-MST had not been reported in human BC tissue until 2016 when Gai et al. demonstrated H2S metabolism dysregulation in BC by revealing low H2S expression and productivity in healthy bladder tissues, moderate expression and productivity in NMIBC tissues, and high expression and product...

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PMC9621239

Annexin V-PE and 7-Aminoactinomycin D (7-AAD) (559763, BD Biosciences, USA) were used to label dead cells, following the manufacturer's instructions.

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PMC11666785

If the centroids are found to lie within the theoretically estimated diffraction-limited spot (r ~ 1.2λ/2NA), then the respective Gaussians are correlated.

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PMC8956657

We next examined the effect of a MERS-CoV ORF4b His to Ala (H26A) mutation within the minor site and found that the structure was almost identical to the MERS-CoV WT ORF4b NLS (Fig. 3C).

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PMC11342785

D, cluster disassembly kinetics in cells across different TPPP variants.

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PMC7823217

Pancreatic adenocarcinoma is the second most lethal cancer in the world.

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PMC9960565

After the coordination of the PAMAM dendrimer to cisplatin in a bidentate form, the cisplatin band shifted from 203 to 247 nm, 242 nm, and 241 nm for G1.5COO(Pt(NH3)2)8, G2.5COO(Pt(NH3)2)16, and G3.5COO(Pt(NH3)2)32, respectively.

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PMC11767817

DKK4 proteins can inhibit the activity of the Wnt/β-catenin signaling pathway , which involves diverse physiological processes such as proliferation, differentiation, apoptosis, migration, invasion, and tissue homeostasis .

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PMC6799808

Similar data were obtained in one-solution assays (Fig. 1c, d).

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PMC11739484

Mechanistically, MMP overexpression may contribute to resistance through remodeling of the extracellular matrix, which can limit drug penetration, or by activating survival signaling pathways that confer resilience against therapeutic agents.

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PMC5874706

All drug-loaded nanoparticles caused more cytotoxicity against A-427 cells than THN7 alone.

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PMC7553912

To date, there are no mouse models for Randall’s plaque, except for a mutant mouse lacking ABCC6 (ATP-binding cassette sub-family C member 6).

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PMC11638255

a Overrepresentation analysis of pathways relatively enriched in TEPA-treated immune cell clusters compared to control, presented as nodes with associated genes as branches using single-cell RNA sequencing.

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PMC11755519

The tube formation and migratory capacity of HLECs were markedly increased after incubation with EVs secreted by UM-UC-3 and T24 cells.

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PMC7185206

This suggests that this resistance is mediated by ADAM10 and/or ADAM17 and requires PD-L1.

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PMC9712534

Only a small fraction of the molecules transiently reside in their sites of action, typically on the order of seconds.

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PMC9424261

E mRNA levels of HERPUD1 in tumors were analyzed by qPCR assay after drug treatment.

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PMC11657744

Nuclei were stained with 4’,6-diamidino-2-phenylindole (DAPI) (Invitrogen).

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PMC11699042

An expansion of these analyses by exploring non-synonymous SNPs that affected the coding sequence and splicing regions for the 11 different A-673 strains (including two A-673 with genetic modifications) using Illumina Global Screening Arrays (GSA) revealed that 98.9% were shared by all strains (Fig. 1c), which drastica...

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PMC11694625

Cell apoptosis and ROS intensity were detected by a flow cytometry (Beckman coulter CytoFLEX, America).

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PMC9429973

Methods: To study the effect of the ERCC6L2 and SDBS germline mutations on cellular metabolism in isolation from the effect of accumulating somatic mutations in the bone marrow, we examined patient-derived skin fibroblasts (ERCC6L2 syndrome, n=2; SDS, n=2) and healthy controls (n=2).

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PMC11082662

All patients with ovarian cancer had primary cancer and were aged between 51 and 69 years, with an average age of 58.95±6.83 years.

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PMC11615743

To synthesize the D‐DNA/L‐DNA chimera, 1000 Å CPG powder (20 g) was weighed and placed on a DNA synthesis column, with the two ends of the synthesis column fixed with plug plates.

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PMC9429973

Median OS was longer with gilteritinib (9.0 mo) vs SC (4.7 mo; HR 0.549 [95% CI: 0.379, 0.795]; P=0.00126); 1-year survival rate was 33.3% and 23.2%, respectively.

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PMC9429973

First interim data will be made available by the end of 2022.

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PMC9429973

The median viability was 96% (92-99.7).

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PMC6643347

In 1988, during the International Humic Substances Society meeting, it was suggested that humic substances might offer significant promise as drugs for treating diverse diseases .

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PMC11765243

Single-cell suspensions were incubated for 15 min with 10% heat-inactivated normal mouse serum in ice-cold staining buffer (PBS with 2% heat-inactivated FBS) to block Fc receptors and then with the indicated labelled antibodies to detect cell-surface molecules; after extensive washing, they were analyzed by flow cytome...

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PMC11352746

Fixating cells can introduce artifacts and obscure cellular behaviors, potentially confounding experimental results.

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PMC11628904

In the larval stage, zebrafish have a stratified epithelium composed of two layers of keratinocytes and a collagen‐rich dermis, providing an anatomically simplified model to investigate cellular behaviour in response to burn injury.

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PMC5308810

To design new and more effective treatments, it is essential to understand how chemotherapy induces drug resistance.

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PMC9688728

Each sample (1 µL) was injected through the glass liner (Restek, Bellefonte, PA, USA) under split mode (50:1).

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