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PMC9429973
Wilcoxon rank sum and Kruskal-Wallis tests were used to compare 2 and 3+ categorical groups; Cox proportional hazards were used to compare groups with time-to-event data.
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PMC11599565
Few cells dually positive for TH and Chromogranin A (ChgA) are detected in regular ovarian tissues (I-L), whereas massive amplification of both antigens are detected in ovarian carcinoma tissues (M-P), as detected by IHC techniques (ICC: ChgA in green, TH in red and DAPI in blue).
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PMC11190538
Also, the size distribution (PDI) for 1:1 formulation was 0.379.
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PMC11530949
Different extract secondary metabolites have been found on the outer layer of the doped NPs, as confirmed by the results of characterization techniques including UV-Vis, XRD, FTIR, and EDX tests.
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PMC9960565
Figure S2 shows the ¹H-NMR spectrum of the monodentate G0.5(COOPt(NH3)2Cl)8 with the characteristic signals of the anionic PAMAM dendrimers at 2.65, 2.83, 2.97, 3.26, 3.34, and 3.64 ppm.
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PMC11764090
This mechanism provides O. sativa with enhanced cold tolerance.
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PMC11473750
c RT-PCR of MYCN mRNA expression levels following 48 h of siRNA knockdown of RNF121.
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PMC11757230
However, mice co-injected with higher doses of cADSCs exhibited lower bioluminescence intensity at each time point than those co-injected with lower doses or no cADSCs (Fig. 5b).
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PMC9429973
Most patients experienced a reduction in disease burden at first interim restaging with a mean decrease of SPD -36.3% (0 to -81.2%).
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PMC11321678
In addition, in the GO cellular component enrichment analysis of subgroup marker genes, we also observed the enrichment of neuron‐to‐neuron synapse and synaptic components (Figure S6A, Supporting Information).
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PMC11332076
Immunocytochemical analysis demonstrated ERK phosphorylation in Cos-7 cells expressing myc-tagged F-iIR or F-iIGF1R (arrows).
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PMC11461833
E,F) Heatmap of SASP related genes and SASP pathway genes that were differentially expressed between empty vector-overexpressing and STXBP5 overexpressing HA-progerin-expressing HEK293 cells. (
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PMC7053076
These analogs were all highly cytotoxic against leukemia HL-60 cell line.
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PMC11627060
For instance, following treatment with macrophage inflammatory protein supernatant, Bax translocates to the mitochondria within 2 h. The upregulation of mitochondrial Bax is associated with a decrease in AIF and cytochrome c levels.
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PMC9429973
Overall RR was borderline (8.5%(3/35) in G1 vs 27.1%(19/70) in G2, p=0,051).
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PMC11792090
CAR-T cells were injected into non-tumor-bearing mice, and the quantity of CAR-T cells in the mouse blood was continuously monitored.
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PMC11481779
We further concatenate it to the final output of the encoder of (512, 256, 256).
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PMC8540692
Next, in the attempt to unravel the molecular mechanisms underlying CCM and NaBu-mediated growth inhibition and apoptosis induction, we performed the oxidative stress analysis of the cells treated with the analyzed compounds and their combination.
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PMC10565698
Fig. 1Expression and cyclic structural properties of circUSP10.
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PMC11470999
Brain metastasis often manifests as neurological impairment, indicating poor quality of life and limited survival.
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PMC7724160
Graphing the NMR glutamine measurements, we observed the glutamine levels were elevated for cells from the passage 25 culture but remained at lower levels for cells with other passage lengths.
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PMC9429973
Sixty-eight (84%) pts received rituximab monotherapy and 13 (16%) pts received rituximab plus CT as first line of therapy.
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PMC9429973
The majority of patients were diagnosed with stage I disease (76%; n=32).
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PMC11701801
The cells were then reseeded and transfected repeatedly with the indicated siRNAs for 48 hours.
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PMC7305184
Figure 4Permeabilization and survival in 30 generation.
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PMC11351758
As expected, a dose-dependent toxicity of glucose on the cells was observed, and significantly greater toxicity was found in the NARP cells compared with the parental 143B cells (Figure 1B), indicating that NARP enhances toxicity.
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PMC11756514
Resistant clones were separated by limiting dilution into 96-well microtiter plates.
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PMC11708541
Their findings pointed to the implementation of effective medicine for XO (Scheme 7 and Table 4).
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PMC11536589
Furthermore, PKF-118-310 administration markedly enhanced the therapeutic efficacy of KRAS inhibitor MRTX1133 in both in vitro and in vivo models of MRTX1133-resistant PDAC cells and tumors.
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PMC9429973
Methods: We have studied the effect of the most prevalent GATA3 mutation (c.827G>A, p.R276Q) in ETP-ALL on normal human T cell development using in vitro differentiation cultures.
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PMC6222726
The authors determined the absolute configuration of these compounds by comparing the vibrational circular dichroism spectra of known podophyllotoxin and deoxypodophyllotoxin with those obtained by density functional theory calculations.
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PMC9429973
Methods: We collected samples of FL patients either at diagnosis (n=35) or at relapse (n=34) from March 2019 to December 2021 (median age: 61 years [27-81]; 40M/29F).
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PMC10079526
Epigenetic dysregulation is often linked to cancer, via amongst others altered transcription patterns of oncogenic and tumor suppressor genes .
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PMC11637276
Integrin/ECM binding triggers the activation of several signalling pathways, including the mitogen-activated protein kinase (MAPK) pathway.
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PMC11347429
FBXO39 (F-Box Protein 39) is a member of the F-box protein family, containing an F-box motif.
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PMC11708541
4-AP markedly decreased muscle atrophy while increasing muscle thickness and contractile force, in addition to enhance in vivo function.
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PMC11078693
Firstly, this protocol was tested only on one type of semi-adherent cell line, RPMI 8226.
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PMC9429973
V. Ho, R. F. Duarte, J.-J. Boelens, M. S. Cairo, R. E. Champlin, S. Giralt, M. Hamadani, C. S. Higham, J. H. Jerkins, J. Laurence, S. Mayer, R. Nakamura, O. Penack, M.-A. Perales, G. Rondón, M. Scordo, S. Hingorani, S. Vasu Dana-Farber Cancer Institute, Boston, United States of America; Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain; Memorial Sloan Kettering Cancer Center, New York; New York Medical College, Valhalla; MD Anderson Cancer Center, Houston; Medical College of Wisconsin, Milwaukee; UCSF Benioff Children’s Hospital, San Francisco; Weill Cornell Medicine, New York; City of Hope Comprehensive Cancer Center, Duarte, United States of America; Charité Universitätsmedizin Berlin, Berlin, Germany; Seattle Children’s Hospital, Seattle; The James Cancer Center, Columbus, United States of America Background: Transplant-associated thrombotic microangiopathy (TA-TMA) is a serious and potentially life-threatening complication after allogeneic hematopoietic cell transplantation (alloHCT).
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PMC6617630
p < 0.05, **p < 0.01, ***p < 0.005 Combinatorial effect of BET and BCL-2 inhibitor ABT-199 on WT-MYC and THL.
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PMC11627133
Compared to other FLAPs, RhoBAST is particularly suitable for SMLM due to its fast dye exchange kinetics, high brightness, and outstanding bleaching resistance.
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PMC10890307
Furthermore, drugs that block glucose, lactate, and glutamine consumption will continue to have limited success, given that under acidosis, the specific rates of glucose, lactate, and glutamine consumption diminish.
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PMC11627060
Recent insights into the mechanism by which TQ induces cell death in human lung tumors have revealed that TQ typically disrupts signaling through the AKT/phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways .
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PMC11740573
After 24 h and 48 h, cells treated with calcitriol, either prior to or post-bacterial stimulation, demonstrated a general down-regulation of both cytokines compared to cells stimulated only with bacteria.
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PMC10777969
We concluded that, in both cases, the N-adduct is formed as the only product.
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PMC10203589
By Agilent Whole Human Genome Array GeneChip microarray analysis, FGF18 was significantly upregulated in ESC cultures in response to estrogen stimulation.
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PMC9046263
Our analysis of ERVK3-1 expression in clinical samples has demonstrated a potential survival detriment in patients with elevated ERVK3-1 expression, marking the first such analysis of a HERV transcript as a negative prognostic marker in GBM.
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PMC9429973
Methods: To better understand the role of TP53 in MPN phenotype and evolution in steady state hematopoiesis, we developed a transgenic model of vav-cre induced JAK2V617F expression in TP53 knock-out (KO) animals and analyzed phenotype, survival, genetic modifications using stem cell compartments RNA-Seq and response to therapy of this triple transgenic mice.
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PMC9428827
For further purification, aGE AKTA explorer system was used; the protein was extracted with 6 M of guanidinium hydrochloride–TE at 0.1 g/ml (wet weight), and renaturation was carried out by dialysis.
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PMC11371627
Real-time PCR was performed using the TaqMan Gene Expression Assay.
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PMC8526701
BRD9 inhibition sensitized GISTs to imatinib by cotargeting the AKT/GSK-3β/NF-κB axis, leading to PUMA induction.
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PMC11699465
In our lab, to clarify the cellular localization of TMEM199, we performed co-immunoprecipitation coupled to mass spectrometry (co-IP/MS) assay.
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PMC11122631
The conformational search of two isomers was executed by Spartan 20, and the lowest energies of each conformer were calculated using Gaussian 16.
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PMC11759543
Measurement of tumorsphere diameter and statistical analysis by one-way ANOVA with Dunnett's multiple comparisons test of Prism 9.
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PMC11271800
Macrophages will only transition into tumor-associated macrophages (TAMs) under specific environmental conditions.
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PMC8750422
Intracellular NO is closely associated with tumorigenesis and cancer progression.
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PMC11754094
We further conducted PCR bias comparison with two long DNA fragments (418 bp and 1,493 bp) and confirmed that KOD (Multi & Epi) DNA polymerase maintained the relevant performance in terms of the PCR length bias (Extended Data Fig. 4d–f).
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PMC8992508
Bifendate showed MDR reversal activity in vitro and in vivo, increasing intracellular accumulation of anticancer drugs and promoting cancer cell apoptosis through inhibition of P-gp.
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PMC6379402
In each iteration, a randomly selected existing node v is duplicated into a new node u. This new node is connected to all of the neighbors of v and may be connected to v with probability p. Divergence is achieved by considering all of the shared neighbors of u and v and removing a connection with a probability q (chosen to mimic the edge density of an input network).
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PMC11343332
The cells were given the medication (20 ug) for 24 hours, after which the cells were extracted and cleaned with ice-cold PBS (phosphate-buffered saline).
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PMC9429973
The overall mortality (OM) at 2, 5 and 10 years was 21.5, 29.3 and 38% respectively, with a corresponding non-relapse OM of 10.3, 13.6 and 16.7%.
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PMC6461034
Centrifuge the mixtures for 30 s at 2,000 × g and 4°C.Transfer the supernatant (unbound fraction) to a 1.5‐ml LoBind Eppendorf vial for checking and orthogonal purposes.
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PMC11617590
The presence of sulforaphane (SFN) in cruciferous vegetables has been found to possess anti‐cancer effects in gastric and colon cancers.
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PMC8992508
Furthermore, 39 showed no stimulation of the P-gp ATPase activity, suggesting it was not a P-gp substrate.
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PMC11752740
As an effector caspase, Caspase3 plays a crucial role in executing cell death by cleaving proteins vital for maintaining cellular integrity .
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PMC10671321
Images were analyzed using Fiji Software (version v1.54f, Zurich, Switzerland) and HCS Studio software as previously described .
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PMC9220170
Transfection of A-172 cancer cells with each of the constructs made it possible to identify the most effective of them.
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PMC11628904
Importantly, C. albicans was viable within colonised tissue and able to develop hyphae, which is essential for potential tissue invasion (Figure S2A).
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PMC9813422
Mechanistically, the enrichment of H3K9me 3 was significantly decreased in shEBNA1, which induces the dissociation of EBV episomes from host chromosomes (44).
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PMC11310713
After 12 weeks following the injection, shown in Fig. 3C, the GTBs remained securely in their position, and there was clear evidence of well-developed blood vessels in the surrounding area (red arrow in the inserted photograph, Fig. 3C).
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PMC11489351
Finally, we showed that a subset of TFs involved in development, cell state regulation, and phenotypic plasticity have pHi-dependent posttranslational activity.
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PMC11357960
The sequences of real-time PCR primers were shown as Supplementary Table 1 .
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PMC11243198
In particular, GlaB and vismione E (Figure 8), which were previously discovered by Infante et al. , were used to generate a multi-feature pharmacophore that identified thiophene and pyrazolo-pyrimidine compounds that were predicted to dock in the same binding pocket as GlaB .
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PMC11585565
However, the mechanism by which missense variants lead to a reduction in CNNM4 mRNA half-life remains unclear and requires further investigation.
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PMC11594806
Gemcitabine (GEM) is commonly used to treat sarcomas, particularly when other treatments have been unsuccessful.
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PMC11672617
Student’s t-test was used for statistical comparisons of results.
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PMC11790599
Dual inhibitors of mTORC1/mTORC2, such as OSI-027, PP242, MLN0128, and Torin 1, induce catastrophic vacuolization in tumor cell lines from various tissues (Srivastava et al., 2019).
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PMC9429973
Male and low education are the susceptibility factors for infection.
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PMC11026382
For example, prior work has shown that mutations at position 28 increase Km.
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PMC9429973
IO and oxidative stress were analyzed by flow cytometry.
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PMC11726848
The medium was replaced with the fresh serum-free medium containing 0.5 mg/mL MTT (Alfa Aesar, Ward Hill, MA, USA) followed by incubation for 3 h. Formazan formed from the reduction of MTT by mitochondrial dehydrogenases was dissolved in dimethyl sulfoxide (PanEco, Russia).
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PMC11291490
ChPBMCs were isolated from 20-day-old chickens by the same method as duPBMCs.
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PMC11734514
Previous analysis showed the cytotoxic impact of Callyspongia aerizusa (C. aerizusa) extract containing ergost-22-en-3-one and ergost-7-en3-ol against A549 lung cancer cells, with an IC50 value of 9.38 μg/mL. However, the extract did not have cytotoxicity towards Het-1A esophagus epithelial cells.
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PMC11361748
Two-way ANOVA. (
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PMC9878562
Moreover, it could explain why cells, which are in the proximity of a LTB4 secreting cell, respond more efficiently to CXCL12 ( Figure 4E ).
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PMC11349530
Stimulation of B cells with breast cancer cell-conditioned media caused the development of regulatory B cells (Breg) contributing to tumor evasion from the immune response (16, 17).
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PMC11422497
circ_SMA4: circ_103870.
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PMC11626627
EMT disrupts intercellular connections, causing epithelial cells to detach from each other and acquire the migration characteristics of mesenchymal cells .
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PMC11549062
Additionally, overexpressing of PDGFR slightly rescued the slowed‐down endocytosis resulting from PTP1B inhibition (Figure 2D).
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PMC9429973
EFS was inferior to those reported in other studies (70-100%) too.
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PMC7642379
Evaluation of common DE genes between adherent and suspension HEK293 cells identified cholesterol biosynthesis as the main enriched pathway. (
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PMC11640476
The simplicity and sensitivity of the resazurin assay make it particularly advantageous for assessing the cytotoxic effects of various substances on several cell lines, including A549 cells .
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PMC11750696
CD8 T lymphocytes, integral to immune surveillance against cancer and pathogens (58), undergo differentiation processes influenced by ER stress.
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PMC11687167
Patients at high risk for CV events with high LDL-C levels 2.
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PMC10079526
B The panel of ten lymphoma cell lines was treated with 5-Aza-2’ at a dose range of 0.01–10 µM and cell viability was measured after 4 days.
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PMC9429973
ORR was higher with PVd vs Vd in NF (P < 0.001) and F (P < 0.001) subgroups.
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PMC8735881
The cell surface expression of GPI-anchored transgenes and HIV receptors was determined by flow cytometry analysis (FACS) as described previously .
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PMC11786767
An LD LCI Plan-Apochromate 40X/1.2 Imm Corr DIC M27 objective was used for Z-series image acquisition.
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PMC11752767
As superficial soft tissue tumor, cutaneous melanoma offers unique advantages for its early diagnosis and detection.
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PMC11541241
Structures and complexes of TOR kinase in the model fungi Saccharomyces cerevisiae and Schizosaccharomyces pombe. (
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PMC3813807
The data analysis was performed using the 2 method (15).
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