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The joint national committee (jnc) 7 defined resistant hypertension as failure to achieve goal blood pressure (bp) (<140/90 mm hg for the overall population and <130/80 mm hg for those with diabetes mellitus or chronic kidney disease) in a patient who adheres to maximum tolerated doses of 3 antihypertensive drugs inclu... |
Kidney diseases including chronic kidney disease (ckd) and acute kidney injury (aki) are rapidly increasing worldwide . Nowadays the incidence of aki varies from 140 to 620 per million people based on different reports and is becoming a global concern [2, 3]. Recently, although the understanding on ckd and aki was subs... |
Despite recent advances in endovascular techniques and technology for coil embolization of intracranial aneurysms, thromboembolic complications intra- and post - procedure are not uncommon, particularly in branches originating from the dome of the aneurysm . Surgeons often face the dilemma of achieving complete coil ob... |
There has been little research into how human immunodeficiency virus (hiv) infection and the aging process together influence the health and well being of infected individuals, which poses many challenges for health care providers, as well as for policy makers.1 given the advent of highly active antiretroviral therapy ... |
Costa rica, with a total land area of 51,100 square kilometers, is a country slightly smaller than the state of west virginia and has a total population of 4.02 million (1). The indigenous population, residing on twenty - two indigenous reserves, comprises only 1.7% of this population . There are currently six indigeno... |
Posttraumatic stress disorder (ptsd) is a psychiatric condition that develops after exposure to a trauma in the form of a threatened or actual harm, death, or sexual violence . The first describes intrusion symptoms, such as nightmares, flashbacks, and unwanted memories of the traumatic event . The second is defined by... |
Positron emission tomography (pet) is a powerful quantitative tool for in vivo imaging compounds labeled with positron emitting radioisotopes that trace biological processes in the body . However, in many occasions, the biological parameters on the image voxel level as determined by conventional statistical estimation ... |
Staphylococcus aureus is known as one of the most important human pathogens frequently implicated in nosocomial infections . S. aureus has the ability to grow in different environmental conditions and as a part of the normal human flora, it can colonize areas such as the anterior nares, perineum, armpit, and groin . In... |
Patients with intestinal failure (if) usually require home parenteral nutrition (hpn).13 although lifesaving, hpn carries an increased risk of complications, including catheter sepsis, venous thromboembolic disease and if - associated liver disease (ifald).3 4 the risk of liver pathology in if is well recognised.5 caus... |
Since the publication of the landmark report to err is human by the institute of medicine in 2000, studies of errors in medical practice had been increasingly performed . There is no doubt that ensuring patients' safety is a clinician's most fundamental responsibility . To prevent errors from occurring, it is important... |
Congenital posterolateral diaphragmatic hernia (cdh) or bochdalek hernia (bh) is a life - threatening malformation characterized by an anomaly of the posterolateral foramina of bochdalek, through which the abdominal viscera migrate into the chest during fetal development.1 the incidence of cdh is 1 in 2,500 to 3,000 ne... |
Biomarkers of airway inflammation and oxidative stress can be measured noninvasively using exhaled breath condensate (ebc) sampling of airway lining fluid . Leukotriene b4 (ltb4), a potent neutrophil chemoattractant, and 8-isoprostane, which is formed during oxidative stress conditions by free - radical peroxidation of... |
In 2010, young adults aged 1825 reported the highest prevalence of current use of a tobacco product (40.8%) compared to youth (ages 1217) or adults (ages 26 and older). Although young adult (aged 1824) cigarette smoking prevalence decreased overall (24.4% to 20.1%) from 2005 through 2010, the highest prevalence of smok... |
The international classification of headache disorders recognizes three subsets of low volume headache, one of them being spontaneous intracranial hypotension (sih). Sih has been attributed to a breach of dural diverticulae or tearing of nerve root sheaths . There may be a clear trigger or at times it may occur without... |
Postoperative endophthalmitis following cataract surgery could have potentially devastating consequences of severe vision loss or even blindness . The average time from surgery to presentation of endophthalmitis is usually 6 - 7 days . This is a rare cause of endophthalmitis in the postoperative setting following catar... |
Construction workers are engaged in a wide range of activities and often become victims of different occupational diseases and injuries . Road construction workers include asphalt workers, ground preparation workers, and heavy vehicle operators who are directly or indirectly exposed to occupational hazards such as dust... |
Upper extremity's (ue) motor coordination, manual dexterity, muscle strength and sensibility are essential for adequate performance of manual tasks (1). Manual asymmetry refers to the tendency to favor one hand for performance of skilled manual tasks, and is important in every sensory and motor function (2). Superior p... |
Nodal involvement is the most important prognostic factor in determining survival for patients with non - small cell lung cancer (nsclc) (1, 2). However, conventional lymph node (ln) staging does not effectively reflect the wide differences in ln involvement and patient survival, even in patients classified within the ... |
Brown - sequard syndrome (bss) was first described in 1840 by charles - douard brown - sequard through experiments of spinal cord hemi - section in animal models.1) bss is a rare condition as an incomplete spinal cord injury (sci) that is caused by traumatic events, such as, most commonly, stab wounds, followed by tumo... |
It uses a pencil x - ray beam that's detected after passing through the patient . Both the x - ray source and detector traverse the scanning area with a rectilinear motion ., dpx series, lunar md 7164, wi, with a scan speed of 1 mm / s and a resolution of 0.5 0.5 mm) has a highly stable potential x - ray generator with... |
Alpha - synuclein is associated with both familial and idiopathic cases of parkinson's disease.the precise function of alpha - synuclein remains equivocal.alpha-synuclein misfolds and forms protein aggregates in parkinson's disease and in various in vitro and in vivo models of synucleinopathies.alpha-synuclein has been... |
Orthogonal frequency division multiplexing (ofdm) is multicarrier modulation which provides reliable high speed data rate because of its high spectral efficiency and its robustness against multipath fading channel . One of the significant problems of the ofdm signal is its high peak - to - average power ratio (papr) th... |
Silent myocardial infarction (mi) is common, and may account for 2060% of all mi in otherwise asymptomatic patients over the age of 45 [14]. The diagnosis of unrecognized infarction has traditionally been defined as the presence of pathologic q waves on the electrocardiogram (ecg) of a patient without a clinical histor... |
Treatment of infrabony defects with different grafting materials has provided a reliable method of achieving defect fill . Recent studies indicate, however that regrowth of osseous tissue alone does not necessarily lead to periodontal regeneration . In fact, the most common healing pattern following the graft procedure... |
Fabry disease (fd) is a rare x - linked inherited condition which, due to the absence or reduction of -galactosidase a (gla) activity in lysosomes, results in an accumulation of globotriaosylceramide (gb3) in endothelial cells, smooth muscle cells, peripheral nerves and in other tissues . Patients experience pain, gast... |
The authors would like to thank the institute for pathology of the leipzig university, chairman prof . The authors would also like to thank the department of radiology of the leipzig university, prof . The authors would like to thank the institute for pathology of the leipzig university, chairman prof . The authors wou... |
Ten paid undergraduate students (mean age 21 2 years (sd)) participated in the experiment . Three subjects were left - handed according to coren s test coren (1993), and all others were right - handed . They were treated in accordance with the local guidelines and signed an informed consent form . They were naive as to... |
Archives preserve documents written on papyrus, parchment papers, papers, and electronic supports . These organic, inorganic, and synthetic materials are deteriorated by physical, chemical, and biological agents . As environmental microorganisms can deteriorate the different supports of heritage significance [2, 3] as ... |
The present study reveals 12-month clinical outcomes for 13,133 patients with acute myocardial infarction (ami) who were enrolled in the nationwide prospective korea acute myocardial infarction registry (kamir) between november 2005 and december 2007 . Launched in november 2005, the kamir is the first nationwide, popul... |
The syndrome of idiopathic granulomatous hepatitis as a cause of fever of unknown origin is now well established but only a few follow - up reports have established the clinical outcome . Idiopathic granulomatous hepatitis is a rare disease of unknown cause that is characterized by recurrent fevers and granuloma in the... |
Several studies show that a diet rich in fruits and vegetables has inverse effects on the occurrence of chronic disorders . Antioxidants in fruits and vegetables may help to protect people from chronic disorders such as ischemic heart disease . -carotene, tocopherol, and vitamin c by inhibiting low - density lipoprotei... |
Perfusion, permeability and magnetic resonance spectroscopy (mrs) are now widely used in the research and clinical settings . In the clinical setting, qualitative, semi - quantitative and quantitative approaches such as review of color - coded maps to region of interest (roi) analysis and analysis of signal intensity c... |
Origin and identification of sandflies - the turkmen sahara villages in northeastern iran are a focus of zcl, where l. major parasites are the major causative agent of zcl . Two sister paraphlebotomus species were collected regularly from 18 villages of gonbad kavous and maraveh tapeh in late june and the middle of sep... |
Endemic highly pathogenic avian influenza virus (aiv) h5n1 in poultry has been present since the first occurrence in 1997 in hong kong . Aiv h5n1 circulates in waterfowl and domesticated avian species and has evolved into multiple phylogenetically distinct genotypes and clades [13], with geographically distinct groups ... |
The enzyme 5-alpha reductase converts testosterone to its active form dihydrotestosterone (dht) and inherited sensitivity of the hair follicles to dht is one of the etiological factors in aga . Two types of 5-alpha reductase are seen in humans: type i and type ii . In the scalp, dht responsible for follicular miniaturi... |
This subset analysis is based on the conrad study, which was designed to compare palliative crt versus palliative chemotherapy alone to poor - prognosis patients with unresectable locally advanced nsclc stage iii . The primary endpoint was os, and the secondary endpoints were hrqol, ttp, and toxicity . Included patient... |
Palliative chemotherapy is the main treatment option for patients with metastatic esophageal cancer and good eastern cooperative oncology group performance status (ecog ps). During the last decade, several chemotherapeutic agents [e.g., cisplatin, 5-fluorouracil (5-fu), mitomycin c, irinotecan, vinorelbine, nedaplatin,... |
Kawasaki disease (kd) is a self - limiting systemic inflammatory disease of childhood,1) and the most important issue with this condition is coronary artery complications . The prevalence of coronary artery involvement is approximately 15 - 25%, but it decreases to 5% after the introduction of intravenous immunoglobuli... |
Melanocytoma presents as a deeply pigmented tumor and rarely arises in the iris or ciliary body of the eye . It usually appears as a focal tumor, slowly enlarging and invading the anterior chamber angle, and may develop secondary glaucoma [1, 2]. The mechanism of the intraocular pressure elevation has not yet been eluc... |
Duplicate (or redundant) publication can be defined as " publication of a paper that overlaps substantially with one already published in print or electronic media " (1). The practice of duplicate publications is considered unethical because it both artificially exaggerates the findings or ideas and wastes the time and... |
Malignant neoplasms of the paranasal sinuses and nasal cavity are rare, comprising only 3% of all head and neck malignancies . This includes both primary sinonasal neoplasms like squamous cell carcinoma, nasopharyngeal carcinoma, lymphoma, esthesioneuroblastoma, primary sinonasal melanoma and adenocarcinoma of minor sa... |
A 33-year - old south indian male presented with complaints of pain in the left eye (le) with painful eye movements since 25 days and gradual progressive worsening of vision in his le since 20 days . There was no history of fever, chronic cough, evening rise of temperature, lymphadenopathy, contact with tb, trauma, hea... |
The 95 ankles from 57 patients with achilles tendon tightness were included in the study . The first group (idiopathic) consists of the patients with no other specific disorders (n = 26) or with disorders not involving the muscle and the tendon, such as flat foot (n = 13) and tibial or femoral torsion (n = 4). The next... |
Cryptococcosis is an opportunistic fungal infection caused by cryptococcus species, and cryptococcus neoformans is considered to be a major primary pathogen . Although exposure to cryptococcus species is common, the development of symptomatic disease usually requires immunosuppression . With an increasing number of imm... |
The disease is named after victor babes, the hungarian pathologist and microbiologist who identified intraerythrocytic microorganisms as a cause of febrile hemoglobinuria in cattle in 1888 . Then in 1893, theobald smith and frederick l. killborne identified a tick as a vector for transmission of babesia bigemina in tex... |
Thus, there must be excellent candidates for the rapid and inexpensive diagnosis of cvd . C - reactive protein (crp) is the most widely used as a cvd marker for the early diagnosis of the disease . Recently, the usual way to predict cvd is detecting the concentration of crp in serum . The most common approaches in anal... |
Hepatocellular carcinoma (hcc) is one of the most common neoplasms in the world . Multidetector row computed tomography (mdct) has been proven to be useful in displaying the relationship between the tumor and the hepatic blood vessels, which is greatly helps guiding surgery . During the mdct procedure, multiple phases ... |
Some persons have ideas of suicide that they will never act on; some plan for days, weeks, or even years before acting and others take their lives seemingly on impulse without premeditation . Many of those attempt suicide by intention, that is, they want to die strongly . Subsequently, after the suicidal attempt when t... |
Kidney injuries following blunt abdominal trauma in humans are described in 310% of cases [1, 2]. The most common cause of blunt renal trauma is the mechanism of rapid kidney deceleration, which occurs in motor vehicle accidents, falls from height, or on a direct impact in the lumbar area . These may result in damage t... |
Rosai dorfman disease is a benign histiocytic proliferation that can present with large lymph node masses, most often cervical . The extranodal disease occurs in about 43% and it usually includes skin, soft tissues, respiratory system, genitourinary system, bones, central nervous system (cns), orbit, thyroid and breast... |
A 71-year - old man with a high alcohol consumption was transferred to our hospital due to altered consciousness . He was admitted to the referring medical center twice, in april 2003 and january 2004, because of altered mental state and unsteady gait . At that time a neurologic examination showed astasia, paresis of l... |
Cefoperazone is a third - generation cephalosporin antibiotic effective in treating pseudomonas aeruginosa infections, which are otherwise resistant to other antibiotics . Although the drug is mainly excreted in the bile, urinary excretion primarily by glomerular filtration accounts for up to 30% of a dose unchanged wi... |
Atrial fibrillation (af) is the most common cardiac arrhythmia, which in 2010 was estimated to affect about 33.5 million individuals in the world, with a prevalence around 2.33.4% among adults, and may reach 9% in those aged over 80 years . Studies point to an increase in both incidence and prevalence [1, 4, 5], as wel... |
The acid - etch technique creates a strong bond between the direct bonding materials and enamel, but debonding of the brackets and improper finishing and polishing at the end of treatment have the potential to cause iatrogenic enamel damage4, excessive plaque accumulation, gingival irritation and increased surface stai... |
Medicare in essence is the largest health care insurance provider in the u.s . And the largest government - funded medical entitlement program . Our cohort was restricted to those individuals enrolled in medicare parts a and b fee - for - service with diabetes in 2006, 2007, or 2008 . A beneficiary was included if, at ... |
Randomised controlled trials (rcts) in attention deficit hyperactivity disorder (adhd) have shown that long - acting methylphenidate (mph) preparations have similar efficacy to multiple doses of short - acting, immediate - release (ir) formulations, but with the advantage of convenient once - daily dosing [4, 15, 16]. ... |
In 1974 sir james paget described the clinical entity, now known as paget's disease as an eczematous change in the nipple preceding an underlying mammary carcinoma. Paget's disease accounts for 14% of all breast malignancy, the most of them are associated with underlying invasive breast cancer . We present the case of ... |
It is an indubitable fact that financing is a core necessity for sustainable health care delivery . The world health organization maintains that health financing is fundamental to the ability of health systems to maintain and improve human welfare . Despite this, financial inclusion with regards to healthcare describe ... |
These couples should receive preconception counseling on all factors that are discussed during preconception counseling for patients without fertility problems . Additional counseling should address success rates and possible risks from the specific fertility treatments being considered because of the couple s diagnose... |
Lactic acidosis (la) is defined as a state of decreased systemic ph (ph <7.35) and an elevated plasma lactate concentration (> 5 mmol / l). Typically, la is divided into disorders associated with tissue hypoxia (cohen and woods classification type a) and disorders in which tissue hypoxia is absent (type b). Type a la m... |
We have investigated photochemical reactions of dab with qds at ensemble and single - molecule levels by recording and analyzing pl spectra of qd solutions and pl intensity trajectories of single qds both in the presence of dab and under high - intensity photoactivation . 1a shows the effect of concentration of dab on ... |
The hunt study consists of three surveys in 19842008 where the entire population of the norwegian county of nord - trndelag was invited to participate . In 19951997, 66,140 men and women (71.2%), aged 20 years or older, participated in the second of these surveys (hunt2), consisting of questionnaires, physical examinat... |
Mccune - albright syndrome (mas) is a rare and sporadic disease characterized by a triad of poly / monostotic fibrous dysplasia, caf - au - lait macules and hyperfunctioning endocrinopathies2,9). Polyostotic bone lesions and caf - au - lait macules are common, while monostotic bone lesions are rare3). Endocrinopathies ... |
Muscular dystrophy includes loss of muscle strength and muscle mass and leads to gait disturbances resulting in compensatory kinematic and postural adaptation [13]. Eventually, patients lose their ability to stand upright and walk . Clinical gait analysis of subjects with muscular dystrophy is widely used to test the e... |
Due to various biotic and abiotic stress factors under field conditions, crop plant yield reduction can reach more than 50% . Among these abiotic stresses, salinity is the most severe environmental stress affecting more than 800 million hectares of land throughout the world [2, 3]. Unsuitable irrigation was the most si... |
Mucormycosis is ubiquitous in nature and humans usually have a strong natural resistance to the infection . Mucormycosis becomes pathogenic when the patient's general resistance has been altered by metabolic disorders, immunosuppressive therapy, malignancy or other chronic debilitating disorders . The organisms are com... |
Systematic transcriptomic analyses have unveiled a variety of non - coding rnas ranging in size from a few to several thousand bases (miura et al, 2006; chekanova et al, 2007; shi et al, 2009). Recently, a new class of small (1326 bases), transcription initiation - associated rnas, termed tiny rnas (tirnas), has been f... |
The goal is to ensure that safety and morbidity are minimized regardless of the technique that is employed (1). It is the most frequently implemented surgical intervention in children, and one third of all the men in the world are circumcised . The procedure may also be performed for medical reasons (2). However, the i... |
An 11-year - old japanese girl presented to our department with a pigmented lesion on her right leg (figure 1). It was a blue - gray papule approximately 4 mm in diameter with a 4-year history . We suspected that it was a blue nevus or a pigmented reed / spitz nevus . On dermoscopic observation, the lesion showed homog... |
Cysteinyl leukotrienes (cys - lts) are potent inflammatory lipid mediators derived from the 5-lypoxygenase (5-lo) pathway of arachidonic acid (aa) metabolism, initially identified to have important effects on pathogenetic aspects of allergic rhinitis and bronchial asthma and approved in the late 1990s for the relief of... |
Upper extremity (ue) hemiparesis is a frequently encountered post - stroke impairment1; most of the ue functional recovery is thought to occur within the initial 6 months after the stroke, and the extent of recovery is very limited2 . Ue disability has a great impact on the activities of daily living and imparts a heav... |
An 83-year - old male suffering from severe symptomatic aortic valve stenosis and, being a high surgical risk, received an implant of a biological aortic prosthesis (corevalve 29) through the femoral artery . During the evaluation 1a) showed sinus rhythm with an incomplete right - bundle branch block and left anterior ... |
The responsibilities of the specialized surface epithelium of the cornea require it to maintain tightly regulated differentiated properties . There are numerous examples of ocular surface diseases in which the corneal - specific epithelial qualities are not maintained and significant anterior eye physiologic perturbati... |
Stress is a non - specific biological reaction, which occurs in response to physical injuries and stimulations imparted to the body, and it modifies the immune system . In particular, physical stress excites exacerbation of the sympathetic nervous system and increase heartbeat, and imparts negatively influences on the ... |
Ciprofloxacin is a fluoroquinolone derivative in veterinary medicine with outstanding antibacterial activity primarily against gram - negative pathogens, but also gram - positive bacteria and some chlamydia, mycoplasma, and many mycobacterium species . The pharmacokinetics of ciprofloxacin has been investigated in dogs... |
Tyrosine kinase inhibitors (tkis), a form of targeted therapy, redefined the oncologic treatment of multiple malignancies, ranging from chronic myelogenous leukemia to subtypes of non - small cell lung cancer . The first one of this class was imatinib, which revolutionized the treatment of chronic myelogenous leukemia ... |
Obstructive uropathy occurs with frequency of 1 in 1000 live births . In the course of the disease it leads to renal dysplasia, oligohydramnios and lung hypoplasia . Morbidity related to the last 2 symptoms is high, with rates up to 63% . Indication to in utero operations is diagnosed bilateral hydronephrosis connected... |
Conventional radiological procedures are a significant source of radiation exposure to the population, and its use has increased substantially over the past decades . Among all conventional radiographic examinations, lumbar spine radiography is associated with the highest radiation dose, as it is responsible for the hi... |
Stress urinary incontinence (sui) is an involuntary leakage of urine with increased intraabdominal pressure caused by weakness of the pelvic floor musculature, including the bladder neck and proximal urethra, or intrinsic sphincter deficiency . Sui is the most common form of urinary incontinence in women, and about 21%... |
Femoral neck fracture is a frequent and severe injury in the elderly with associated high mortality and morbidity . The incidence of these fractures has increased with improvement in life expectancy and is expected to double in the next 20 years and triple by 2050.1 mortality rate of 20 - 30% in the year following the ... |
Hemophagocytic lymphohistiocytosis (hlh) 1 is a rare and lifethreatening hyperinflammatory syndrome caused by genetic mutations (primary hlh) or systemic acquired conditions (secondary hlh) which in adults is most commonly associated with hematological malignancies 2, 3 . Although primary and secondary hlh have usually... |
A male baby, delivered normally and spontaneously after a full - term pregnancy, was well during the first 28 hours of life . He then became lethargic and hypotonic, and the shallow respiration which began at that point progressed to intermittent apnea, requiring mechanical ventilation . On the 4th day, brain computed ... |
Identifying lymphatic vessels is a key step in lymphatico - venous anastomosis . Because lymphatic vessels are thin and fluid inside is transparent with faint color, it is not easy to spot them with bare eyes . Indocyanine green (icg) lymphography with infrared camera is one of the most powerful tools for identifying l... |
The incidence of differentiated thyroid cancer (dtc) has been increasing during the last few decades, mostly attributable to better detection of small papillary cancer as a result of improved diagnostic accuracy . However, improved detection does not fully explain significant increase in tumours with adverse pathologic... |
Access to accurate and reliable data is an important prerequisite for exploring the cost - effectiveness of healthcare interventions . In particular, information about the numbers, rates and average costs of common invasive procedures, might help policy makers in resource allocation and payment system . In addition the... |
More than 60% of patients with major depressive disorder do not achieve remission following treatment with an adequate course of at least one antidepressant.1,2 for patients who do not obtain adequate benefit from antidepressant therapy, adjunctive therapy with an atypical antipsychotic is one treatment option.3,4 arip... |
The study published by schlenk and colleagues in the previous issue of critical care was initiated by clinical experience that, after subarachnoid hemorrhage, hyperglycemia is strongly associated with complications and impaired neurological recovery . Utilizing intracerebral microdialysis and bedside biochemical monito... |
A 53-year - old indian male employed in dubai, uae presented with a sudden onset of foreign body sensation in his left eye while at work for which he used an eyewash from the first - aid kit . This was followed by an acute bout of pain, redness and watering which was attributed to the eyewash being past the expiry date... |
Chronic renal disease is a major health concern that incurs poor health consequences and high health care costs, with greater prevalence among the elderly . In the last two decades, the number of the elderly patients with chronic renal failure has increased in most countries . Hence, in terms of age pattern, this disea... |
The increase in the range of options available for health and disease management, coupled with the shift towards greater patient involvement in recent years, has led to a profusion of decision aids and related support systems aimed at patient, clinician and medical team . This has been followed by the development of in... |
Side effects of epinephrine such as increased myocardial oxygen demand and consumption, decreased myocardial atp with proarrhythmic effects, or increased intrapulmonary shunting and myocardial dysfunction during the post - resuscitation period are well known [1, 2]. Vasopressin is a potent vasopressor that could become... |
In malawi, queen elizabeth central hospital is the government - funded hospital for blantyre district, serving 1 million persons . From january 1998 through december 2004, persons from the community who came to the hospital with fever (adults> 14 years, axillary temperature> 37c; and children <14 years and> 1 month, te... |
Pb was collected before transplantation from patients with type 1 diabetes undergoing pancreas or pancreas / kidney transplant at san raffaele hospital . These patients donated one pln, which was collected during the surgical procedure using scissors (supplementary fig . Five to 10 plns were also collected from the pan... |
Postoperative adhesion is one of the major complications of strabismus surgery that can cause motility problems that affect the surgical outcomes [1, 2]. Due to the fact that the suppression of inflammation is a key element in the prevention of further fibrovascular proliferation and scar formation in the conjunctiva, ... |
Psoriasis, a common inflammatory skin disorder affecting 1 - 2% of individuals in western societies, is caused by genetic predisposition and can be triggered or affected by various environmental provoking factors, such as mechanical stress (koebner phenomenon), infections, emotional stress, diet, body mass index, alcoh... |
Matrix metalloproteinases (mmps) are zinc - dependent endopeptidases that play a central role in various physiological processes and pathological conditions including cancer and inflammatory diseases . One of the main problems for developing a new class of drugs as mmp inhibitors is the issue of selectivity . This fami... |
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