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This commentary describes the debate and some of the associated issues involving the subluxation construct . The long - standing debate regarding the chiropractic subluxation has created substantial controversy within the profession . Currently, this phenomenon can be compared with a country with a 2-party system that ... |
Structural changes in primary open - angle glaucoma (poag) occur in the optic nerve head as well as peripapillary retinal nerve fiber layer (rnfl).14 while it has been assumed that structural loss of the rnfl anticipates functional visual field loss, the relationship between structure and function in glaucoma is not ye... |
The 2004 national household survey prevalence estimates extrapolate to approximately 130.1 million alcohol users; 18.6 million cannabis users and about 4.3 million opiate users as per 2011 census (as no national survey was undertaken after this survey). As per same calculation, the number of dependent users is also qui... |
The kocher - debre - semelaigne (kds) syndrome consists of congenital hypothyroidism with generalized muscular hypertrophy, particularly involving the muscles of the extremities, giving the child a the cardiovascular manifestations are usually secondary to the long standing hypothyroidism and have been limited to repor... |
This study provides real - world data on adverse events and dosing practice associated with capecitabine monotherapy in patients with metastatic colorectal cancer.hand-foot syndrome and gastrointestinal (gi) events were seen in almost half of the patients treated with capecitabine monotherapy.dose reductions and discon... |
Despite advances in diagnosis and treatment, cancer remains the second highest cause of death in developing countries (jemal et al ., 2011). The vast burden of cancer associated morbidity and mortality is principally attributable to the development of metastases from the primary tumor site through a complicated and mul... |
The demand for fast information transmission is increasingly required . Whether at work or in social interactions, the telephone is a great facilitator in everyday communication . Some individuals with severe to profound hearing loss are unable to directly use the telephone even to call for help in an emergency situati... |
The mechanostat model states that bone adapts by increasing its mass when muscle contraction deforms bone (6). The deformation of bone is believed to alter the flow in the haversian canals and bone marrow, which elicits a mechanical stimulation of the osteocytes that again signals to the osteoblasts (7). One of the pro... |
This is a government hospital catering to the city and at least 10 adjoining districts . Institutional ethics committee approval was obtained beforehand . Written informed consent was obtained from a parent or legal guardian, with the provision of a witness when the guardian was illiterate . Subjects of either sex and ... |
Acquired immune deficiency syndrome (aids) is a disease spectrum of the human immune system caused by infection with human immunodeficiency virus (hiv).1 hiv / aids is a global pandemic.1,2 as of 2012, approximately 35.3 million people have hiv worldwide with the number of new infections that year being about 2.3 milli... |
A 51-year - old female with a past medical history of hypertension and dyslipidemia was referred from her primary care physician to the gastroenterology clinic with complaints of intermittent non - specific abdominal pain for 9 months and mild intermittent watery diarrhea . The patient was an immigrant from senegal, a ... |
Scaffold diversity is one of many parameters that may be used to characterize compound screening libraries. (1) the balance between the diversity of scaffolds within a library and the density of coverage for each scaffold varies according to the library design principles applied . Dense representation over small number... |
Renal biopsy is one of the pivotal diagnostic tools used in the field of nephrology . There are numerous diseases that can cause nephrotic syndrome, nephritic syndrome, and acute kidney injury, which have vastly different prognostic and therapeutic implications, illustrating the importance of histopathological examinat... |
Severe acute respiratory syndrome (sars) is an emergent infectious disease that was epidemic in 2002 and 2003 . Between november 2002 and july 2003, an outbreak of sars in southern china infected about 8000 people and led to 774 recorded deaths, mostly in hong kong . Within weeks the coronavirus responsible for middle ... |
Rheumatic fever (rf) is a known sequela of a group a, -hemolytic streptococcal infection . The incidence of rf has decreased over the past 30 years in korea along with economic growth and environmental i m of rf has decreased over the past 30 years in korea provement.1)2) the major manifestations of rf include carditis... |
The ratio of second and fourth digit lengths (2d:4d), has been highlighted as a potentially useful phenotypic marker of steroid exposure in utero of vertebrates . It is generally postulated that the lower the individual 2d:4d, the higher testosterone but the lower estrogen levels experienced during fetal life . In huma... |
A 16-year old male patient reported to the department of oral medicine and radiology with a complaint of progressive flattening of left side of face since the age of 2 years which was continuous to date . Patient gave a history of pigmentation of his left face since birth which had been gradually fading over the years ... |
Tinnitus is the perceived sensation of sound in the absence of a corresponding external acoustic stimulus . It is a very bothersome symptom for many patients as it can affect the physical and mental health in different degree . Hypertension has been suggested as one potential risk factor of tinnitus in some studies, bu... |
Subarachnoid hemorrhage (sah) is the most frequent intracranial lesion in patients with head trauma.6) traumatic sah is found in 15 - 40% of severe head injuries.5) rupture of a cerebral aneurysm is an important differential diagnosis of traumatic sah, especially in cases of a vague traumatic event without a witness . ... |
Accelerated molecular dynamics (amd) is an enhanced sampling technique that works by flattening the molecular potential energy surface, often by adding a non - negative boost potential when the system potential is lower than a reference energy . The boost potential, v decreases the energy barriers and thus accelerates ... |
These may occur alone or more frequently in combination.9,10 also in common are typical pain descriptors, such as burning or shooting pain with unusual tingling, crawling, or electrical sensations.9 because of its complex etiology, neuropathic pain can be difficult to treat, and the rate of nonresponders to pharmacolog... |
To add the bovine seroepidemiological picture in kentucky to that previously published for minnesota and the united kingdom,,,, we performed a retrospective serological survey of random stored bovine serum samples submitted in 1999 and 2000 for routine diagnostics at the university of kentucky livestock disease diagnos... |
Cytokines are proteins secreted by different types of cells, which in turn act on the cells which secrete them (autocrine action) or on surrounding cells (paracrine action) or which act systemically away from the local source of secretion (endocrine action). Cytokines are critical for many physiologic processes includi... |
In many regions, intestinal parasites represent a very important medical - sanitary problem, due to their large - scale dissemination and high prevalence . This situation is typical of developing countries, where interrelations between etiological agent and host are favored, considering the precarious basic sanitation ... |
Foreign bodies are frequently ingested by young children, mostly by ambulatory toddlers who explore their surroundings orally . Almost 40 percent1 of the ingestion of the foreign bodies are unwitnessed and 50 percent2 are asymptomatic . Depending on the size, shape, content and nature, most ingested small objects on re... |
Composed of a mixture of dermal cells derived from the three germ cell layers (ectoderm, mesoderm or endoderm), primary mature teratomas are rare neoplasms characterized by inclusion of any well - differentiated parenchymal tissues . These tumors are most commonly found in testes and ovaries but extragonadal sites have... |
Evaluation focused on a sample of 10 representative counties and consisted of personal and media surveys . The personal survey assessed knowledge, behavior, and attitudes about wnv (8). Knowledge was measured by asking respondents how wnv is transmitted, who is most vulnerable, and what self - protection measures are a... |
Non - invasive continuous cardiac output (cco) monitors have become popular in operating rooms and intensive care units (icus). However, the inaccuracy of arterial waveform analysis for measuring cco associated with changes in systemic vascular resistance (svr) has been well documented [1, 2]. Sugo et al . Developed a ... |
Schwannomas are rare peripheral nerve tumors arising from schwann cells of the nerve sheath, and they are usually located in the head and neck . Computed tomography (ct) and other imaging modalities may help obtain information about tumor size, location and relationships with neighboring tissues, but they do not give a... |
The strongly established idea that the adult brain has no ability for generating new neurons is now controverted, and recent studies have discovered that the adult mammalian brain can generate new neurons [1, 2]. Even though many studies had a doubt in this idea for a long time, it is now established as the new idea th... |
Primary central nervous system (cns) lymphoma (pcnsl) is a relatively rare tumor, accounting for 1%7% of primary brain tumors and 1%2% of all cases of non - hodgkin lymphoma . Primary lymphoma existing in the spinal cord is also rare, representing <1% of pcnsls in adults . We identified an extremely rare case of primar... |
Zum einen nahm die aachener eisenhttenkunde von der grndung des aachener polytechnikums 1870 bis um die jahrhundertwende trotz der nhe zum rheinisch - westflischen industriegebiet keine herausragende position innerhalb der deutschen httenkunde ein, avancierte dann aber binnen eines einzigen jahrzehnts zum grten und ang... |
The fes cluster of xpd quenches fluorescence of a wide range of fluorophores in a distance - dependent manner . Therefore, the change in the position of the arch domain of xpd relative to the fes cluster - containing domain can be monitored via fes - mediated fluorescence quenching if the arch domain is labeled with a ... |
Foreign body (fb) ingestions in the adult population are frequently incidental and the majority can successfully be removed endoscopically [1, 2]. Patients with prolonged impaction (over 12 h) and those who ingested sharp - pointed objects have a greater risk of complications . Perforations of the duodenum are relative... |
Recent progress in structural genomics has revealed that many proteins have regions with very flexible and unstable structures, even in their native states . Such proteins or regions disordered protein regions often lead to difficulties in purification and crystallization, and become a bottleneck in high throughput str... |
Supplementary material is available for this article at 10.1007/s13659 - 012 - 0003 - 6 and is accessible for authorized users. |
Our view of embedded health assessment is the on - going assessment of health changes based on an individual s behavior and activity patterns and baseline health conditions . Sensors embedded in the environment are used to collect behavior and activity patterns for the purpose of detecting health changes . Early detect... |
Malaria is caused by infection with the protozoan parasite from the gender plasmodium and affects millions of individuals causing serious morbidity . Although p. falciparum is the main cause of deaths, p. vivax is probably responsible for the majority of malaria cases worldwide, with a range of annual infections at 132... |
The family is a large and abundant group which occurs throughout temperate and tropical regions of the world, and well beyond the arctic circle . The family comprises 3,536 species classified in two subfamilies and 112 genera (harbach 2013). There are many studies on mosquito fauna in iran (zaim 1987, vatandoost et al ... |
Zolendronic acid is a nitrogenous biphosphonate commonly used as an intravenous infusion for the management of paget s disease,1 osteoporosis prophylaxis,2 and treatment of hypercalcemia of malignancy.3 uveitis is an uncommon ocular complication of zolendronate . The horizon (health outcomes and reduced incidence with ... |
Macrophage activation syndrome (mas) is characterized by fever, hepatosplenomegaly, severe cytopenia, serious liver disease, and coagulopathy1). Mas is a severe, potentially fatal condition associated with excessive activation of immune cells, leading to hypercytokinemia and overwhelming systemic inflammatory reactions... |
Fish were raised and maintained under a 14 hours light / 10 hours dark cycle at 28c according to standard protocols . To microinject expression constructs and to establish transgenic lines, fish of the brass line brs all animal experiments were approved by the government of lower saxonia and were conducted in accordanc... |
Over the past two years, the introduction of new drug molecules, including new phosphate binders, less - calcemic vitamin d analogues and calcimimetic, have been undergoing an incisive therapeutic change in the treatment of secondary hyperparathyroidism in haemodialysis patients . The novel vitamin d analogs, paracalci... |
Oral route is one of the most preferred routes of drug administration due to its safety, ease of administration, and acceptability by patients . About 60% of conventional dosage forms are available as the oral solid dosage forms . The low bioavailability, longer onset of action, and dysphasia patients turned the manufa... |
Male factor infertility is believed to be responsible for almost 50% of these cases (2). Genetic factors can be blamed for only 10% of cases of infertility in men (3). Male infertility is actually a multifactorial condition in which a variety of other factors including hormonal imbalance, erectile dysfunction, infectio... |
The 1999 institute of medicine report to err is human riveted the medical establishment's attention onto errors made during patient care . A significant portion of the errors occurred during the care of surgical patients, and the report made recommendations for mitigation . Also in 1999, the american council on graduat... |
Adolescent idiopathic scoliosis (ais) is a disease of unknown aetiology, characterized by a complex three - dimensional deformation of the spinal column as the most common paediatric orthopaedic pathology . Its incidence, according to different sources, varies from 2 to 6% of the total paediatric population, while 3 in... |
Unintentional injuries due to motor vehicle crashes (mvcs) are the leading cause of death and long - term disability between the ages of 414 years [1, 2]. When properly installed, child safety seats have been shown to reduce the risk of childhood injury by 71% to 82% and death by 28% relative to seat belts alone [36]. ... |
Water source choice depends on water availability, cost of operation and development, quality of water, and adequacy . It is important to evaluate all alternative water sources to ascertain the cost associated with each source . Economic, environmental, engineering, and energy factors must also be considered when choos... |
Peptic ulcer perforation (pup) is a major crucial complication of peptic ulcer.1,2,4 pup accounts for about 10%15% of peptic ulcer patients and accounts for more than 70% of deaths.1 the mortality rate after pup is approximately 10%15% upon delayed diagnosis.2,3,5 severe upper abdominal pain is the most prominent sympt... |
Although staging can be performed with routine imaging studies, surgical intervention is often required to ensure accurate histologic diagnosis of these lymphomas . Peripheral t cell lymphomas not otherwise specified are among the most aggressive non - hodgkin lymphomas with often a poor response to conventional chemot... |
The first successful minimally invasive surgical nephrectomy was reported in an adult patient by clayman et al . Since that report, the feasibility of laparoscopic management of urological diseases has been described in children including laparoscopic nephrectomy . In 1992, koyle et al reported an 8-month - old infant ... |
Sleep apnea is clinically recognized as a heterogeneous group of disorders characterized by recurrent apneas (complete cessation of breathing) and/or hypopnea (decrease in airflow with desaturation of 4%). It is estimated that obstructive sleep apnea may affect at least 2%4% of the general population, with prevalence e... |
There is a worldwide impetus to develop and measure metrics of research excellence.1 for instance, research benchmarking activities have been established over the last 7 years in australia,2 the uk,3 south africa,4 europe,5 and the usa.6 research metrics have been expressed in different forms in different countries . D... |
Mast cell degranulation represents one of the earliest described examples of a ca - dependent biological process in non - excitable cells (foreman et al ., 1973; kanno et al ., 1973). The capacity for ige - mediated activation of this process via crosslinking of ige receptor (fcri) complexes at the mast cell surface wa... |
As part of a molecular epidemiology study, 203 fecal samples from 203 adult dromedaries (camelus dromedarius) were submitted to the central veterinary research laboratory in dubai, united arab emirates, over a 7-month period (january july 2013). Rna extraction and reverse transcription were performed, as described, to ... |
Different species of barberry (zereshk in persian) grows and is well known in different parts of the world such as iran, china, middle asia, and many countries in europe, africa, and america . Various parts of this plant including its root, bark, leaf, and fruit have been used as folk medicine for long time in iran and... |
Sideropenic anemia is a common pregnancy disorder, with the incidence among pregnant women from 20 to 40% (1, 2). According to who, pregnancy anemia exists if hemoglobin (hb) is lower than 110,00 g / l and hematocrit (htc) lower than 0,31 (3). Rough estimate of hematological pregnant women s status imply checking of hb... |
However, despite the known association of the causative agents (y. enterocolitica, ye, and very rarely y. pseudotuberculosis, ypt) with both gastroenteritis and extraintestinal infections, it remains a poorly understood disease . Sporadic cases are still reported in which food is not suspected as the source of infectio... |
Pandemic influenza a (h1n1) virus was first detected in new zealand in april 2009 among a group of high school children returning from mexico ., the pandemic escalated rapidly in june, and new zealand formally switched to the manage it phase of the pandemic influenza action plan on 22 june . Public health consensus sup... |
It has been reported that one of six men and one of five women (55 - 75 years old) will suffer from stroke sometime during their lives . Three phases have been described in stroke: excitotoxicity, inflammatory activation / apoptosis and regeneration . In stroke, an activation of caspases, cytokines and both nitric oxid... |
A 35-year - old female with a 10-year history of temporal lobe epilepsy had been treated with 1,200 mg of carbamazepine . Recently, her medication had been switched to ltg because of an increase in seizure frequency without any precipitating factors . The dosage was increased slowly to 200 mg per day, and the frequency... |
Approximately 50% or more patients with cancer develop bone metastasis, and this is more common in patients with breast, prostate, and lung cancers.1,2 bone metastasis often involves the vertebral column, pelvis, ribs, and proximal femur, whereas distal femur metastases are rare . The most frequent symptom is intense a... |
Infection with shiga toxin- (stx-) producing escherichia coli (stec) is the most significant cause of hemolytic uremic syndrome (hus), the leading cause of acute renal failure in children [14]. Of the two antigenically distinct toxins, stx1 and stx2, stx2 is more firmly linked with the development of hus as stec strain... |
Platelet aggregation stimulated by collagen is diminished in smokers compared with nonsmokers, suggesting that habitual smoking reduces platelet aggregability . Smokers are more susceptible to aspirin in collagen- and adenosine 5-diphosphate- (adp-) induced platelet aggregation than nonsmokers . Cigarette smoking and a... |
The pelvis and hip are common locations of heterotopic ossifications (ho), often occurring in paraplegic patients . With respect to ho, mr imaging allows for a confident diagnosis in mature ossified lesions only . Plain radiographs and ct may show various phases of ossification: amorphous calcification, immature and ma... |
According to the world health organization definition, cardiac rehabilitation (cr) is a process whereby a person is restored to an optimal physical, psychological, social, emotional, and economic status . Therefore, cr programs consist of risk factor modifications, dietary interventions, psychological supports, exercis... |
Poviena koncentracija homocisteina (hcy) moe predstavljati metaboliki marker nedostatka folata i vitamina b12, znaajnih problema javnog zdravlja . Bolesnici sa hroninom opstruktivnom boleu plua (hobp) skloni su nedostatku ovih vitamina usled razliitih razloga . Studija je sprovedena u grupi od 50 osoba obolelih od hobp... |
Age - related sarcopenia is characterized by a loss of skeletal muscle mass and a gradual decline in the functional properties of the tissue.1, 2, 3, 4 because of the clinical importance of these functional changes, and the demographic changes projected for the next 20 years, considerable attention has been focused on ... |
Elevation of liver enzymes in rheumatoid arthritis patients treated with tocilizumab (actemra) or anakinra (kineret) is a well - documented phenomenon . Similarly, the factors involved in decisions regarding discontinuation of treatment and outcome have not been discussed in the literature to any significant extent . O... |
Alzheimer's disease (ad), the most common form of dementia in adults over age 65, is the fourth leading cause of death in the united states and currently affects 4.5 million americans (1). Estimates indicate that 3% of americans between ages 65 and 74, 19% between ages 75 and 84, and 47% over age 85 are victims of the ... |
Seven different mwcnts (cta, ctb, ctc, ctd, cte, ctf, and ctg) were used for chromosomal aberration assays . (tokyo, japan); ctc, ctd, and ctg were obtained from tokyo chemical industry co. ltd . (tokyo, japan); and ctf was made by shattering cte in an agate mortar . Eagle's mem was purchased from gibco (invitrogen cel... |
Electroconvulsive therapy (ect) was first introduced as a treatment for schizophrenia in 1938, by ugo cerletti and lucio bini . However, in certain situations, for example, treatment - resistant schizophrenia, ect augmentation is still the treatment of choice . Studies have shown that a combination of ect and antipsych... |
Healthcare - associated infections pose a continuing threat for mortality and morbidity among hospitalized patients . Hospital - acquired infections mainly draw attention because of the growing awareness that most of them are preventable . Evidence suggests that proper hand hygiene practice is regarded as the single mo... |
Humans have transported other species beyond their natural ranges for thousands of years, both intentionally for agricultural purposes (diamond 2002) and unintentionally as a consequence of human migration (wichmann et al . Other than disease agents, whose effects are apparent once transposed (mazzaglia et al . 2012), ... |
Fabry disease is an x - linked lysosomal storage disease caused by decreased activity of -galactosidase a (gal - a). If the disease is left untreated, the natural long - term course is associated with severe multi - organ dysfunction of the renal, cardiac and/or cerebrovascular systems.1) therefore, before irreversible... |
Edentulism is a debilitating and irreversible condition and is described as the final marker of disease burden for oral health . Although the prevalence of complete tooth loss has declined over the last decade, edentulism remains a major disease worldwide, especially among older adults (table 1). However, there are int... |
During gestation and up to 2 years of age, the human brain develops at an astounding rate . While brain injury during this critical period can have devastating consequences, the brain has a remarkable capacity for reorganization following perinatal injury [16]. One of the most common disorders is cerebral palsy, which ... |
Although the concept of physiologically based pharmacokinetic (pbpk) modeling was introduced years ago, it has not achieved the scope of development and implementation that it deserves . Still, interest in and use of this modeling technique have grown over the last few years, as evidenced by the large increase in publi... |
Its etiology involves a combination of genetic factors, unfavorable growth pattern, and oral habits . Habitual nonnutritive sucking, altered tongue function and posture, and persistent infantile swallowing, for example, can contribute to vertical malocclusion in the growth period.1,2 several studies have suggested a re... |
Pseudoexfoliation syndrome (pxs) and pigment dispersion syndrome (pds) are common causes of raised intraocular pressure (iop) and secondary glaucoma . Pxs tends to affect an older population, whereas pds is more likely to be seen in a younger, myopic patient cohort . Pxs is a generalised disorder of the extracellular m... |
Our institute is austria`s national reference center for echinococcosis (8). The study comprised 65 patients in whom ae was diagnosed and registered during 19912011; the patients derived from all 9 of austria s provinces . Inclusion criteria were as follows: 1) ae characteristic imaging findings and 2) e. multiloculari... |
Prostate - specific antigen (psa) levels are affected by many factors that may be unrelated to prostate disease, including age and race . Patients with diabetes have been reported to be at an increased risk for cancers of the pancreas, liver, and colon; however, recent studies have suggested that men with diabetes are ... |
Cariostatic efficacy of topical fluorides is attributed to their ability to decrease the rate of demineralization of enamel and enhance the rate of remineralization . There is a current consensus that bacteria - mediated tooth destruction can be arrested or even reversed by adopting fluorides . The fluoride concentrati... |
In addition to the better outcome in cardiovascular disease (cvd) in women, the time of occurrence of cvd is also later . These discrepancies occur due to the significant influence that sex plays on the development of cvd . One of the major influences on cvd is the lipid profile [3, 4] and it is well known that there a... |
Production of basal levels of superoxide (o2) and nitric oxide (no) radical by granulocytes is known to be enhanced in patients with type - ii diabetes . Recently it was reported in healthy subjects that no production by granulocytes is mediated via cyclic amp and cgmp pathways . However, cyclic amp and cgmp - elevatin... |
Enteropathy - type t - cell lymphoma (etl) is primary extranodal t - cell lymphoma arising in the intestine originating from intraepitheial t - cells.1 etl is very rare and accounts for fewer than 5% of all gastrointestinal tract lymphomas . Five - year survival rate is 20% to 25%.2 - 6 the treatment options are chemot... |
Acquired chloridorrhea (acd) is a rare disorder presenting with chloride - rich diarrhea, severe volume depletion, metabolic alkalosis, hypochloremia, hypokalemia, hyponatremia, acute renal failure, and low urinary chloride excretion . This array of derangements is also seen in congenital chloridorrhea (ccd), a neonata... |
Surveillance studies throughout the world have demonstrated that an influenza a virus reservoir exists in wild aquatic birds .,, in the natural reservoir, avian influenza viruses (aiv) replicate primarily in the gastrointestinal tract, are excreted mainly in feces, and are transmitted via the fecal oral route . Early s... |
Stroke is a major cause of death and disability world - wide . By 2020 stroke, together with coronary - artery disease, stroke represents an often devastating disruption to life, the majority of survivors experiencing some degree of impairment requiring additional care or support 1 year post - stroke . Stroke is an acu... |
Since the first introduction of endoscopic endocrine neck surgery in 1996 [1, 2], many different techniques of remote access thyroidectomy without a conventional cervical incision have been developed [3, 4]. Although the pursuit on cosmetic superiority can be achieved, remote access thyroidectomy by the endoscopic appr... |
Laryngeal cancer is a common type of malignant tumor in the head and neck, and the incidence of this type of tumor is increasing yearly . It is believed that this cancer is the result of the combined effects of multiple factors, primarily environmental and genetic factors . Studying the genetic factors associated with ... |
More than 20 years ago, shoemaker and coworkers observed that perioperative alterations in oxygen transport were closely related to the development of organ failure and death . Subsequently, several studies reported that perioperative hemodynamic optimization guided by the pulmonary artery catheter may decrease morbidi... |
A 19-year - old male presented to our medical clinic in mid-2009 with complaints of acne, hair loss, and difficulty in getting up from sitting position with evidence of proximal muscle weakness . He had been recently diagnosed with dermatomyositis based on his clinical features of elevated creatine kinase levels, typic... |
A radical cystectomy (rc) with pelvic lymph node dissection is the gold standard treatment for muscle - invasive bladder carcinoma and remains the most effective method for local control . Rc is a major procedure with the potential for serious complications which commonly develop in the early perioperative period . Alt... |
Determination of binding affinities for protein ligand complexes presents one of the most complicated and attractive problems of computational chemistry . The simplest methods attempting to suggest a solution to this problem (e.g., docking) mostly rely on end - point methods that estimate energies of single static comp... |
A universal characteristic of modern societies, both in developing and developed countries, is the steadily increasing level of noise exposure within our working environments and during leisure time activities (for review see). Consequently, an increasing number of people suffer from hearing disorders that result from ... |
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