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A highly evolutionarily conserved mechanism of cellular management and defense against reactive oxygen species (ros)-induced oxidative stress involves 3 key interacting components: kelch - like erythroid cell derived protein with cap n coller homology (ech)-associated protein 1 (keap1), the nuclear factor erythroid 2-l...
Acute cholecystitis remains a major cause of morbidity, yet despite the improved accuracy of diagnostic imaging, can sometimes be misdiagnosed . The characteristic features of acute cholecystitis on hepatobiliary scintigraphy are transit of the radiotracer from intrahepatic biliary tree into the small bowel, without fi...
A wide variety of halogenated compounds (organohalides or organohalogens) are found in wastewater coming from a variety of sources such as cleaning agents, disinfectants, industrial runoff, and pesticides.1 compounds such as polychlorinated biphenyls, chlorophenols, triclocarban, triclosan, and diclofenac have been qua...
The world health organization (who) has projected that 1.5 billion people globally are likely to suffer from hypertension by 2025 . Hypertension is linked to 57% of all stroke deaths and 24% of all coronary event deaths . Hypertension is ranked as the third most important risk factor for attributable disease burden in ...
The field of computational structure activity modeling in medicinal chemistry has a long history, going back at least 40 years . Methods - oriented papers have generally analyzed statistical performance in terms of numerical prediction accuracy, and application - oriented papers have described predictions made based up...
Best corrected visual acuity (bcva) was 20/300 and 20/20 in the right and left eyes . Cycloplegic autorefractometric measures revealed refractive error of 16.00 (2.25 175) dioptry (d) and + 1.50 (0.75 5) d in the right and left eyes . A - scan ultrasound biometry showed an axial length of 24.84 mm and 21.03 mm in the r...
Despite the availability of a new array of biomarkers and a widely adapted clinically relevant / treatment - oriented approach of classifying breast cancer cases over the last decade, categorization of breast cancer is an ongoing challenge which is being revisited more frequently by the scientific community . The goal ...
Increasing awareness of anthropogenic environmental pollution, and of its implications for human and environmental health, has led to the continuous development of two complementary approaches for assessing the degree of contamination . Physicochemical analysis, using a wide spectrum of analytical instrumentation (bont...
Guidelines for the care and use of laboratory animals uniformly recommend the use of analgesia in any procedure with a potential for pain . Yet one factor that may account for the modest utilization of analgesia is the management challenge involved with intraperitoneal (ip) and subcutaneous (sc) injections of mice and ...
To reconstruct the ancestral habitat, we first built the phylogeny for our sample using 14 molecular markers (figures 1a and s1a). We then assigned each species to one of four niches based on previous descriptions and our own field observations: terrestrial, marginal aquatic with preference for solid substrates, margin...
The current issue of the nucleic acids research features 100 new databases and 82 updates for databases that were previously described in nar or other journals . Inclusion of these databases into the nucleic acids research online molecular biology database collection (http://www.oxfordjournals.org/nar/database/a/, see ...
Erythromelalgia (em) is a rare neurovascular disorder characterized by swelling, erythema, and burning in the extremities in a stocking - glove distribution, which is relieved by exposure to cold but worsened by heat stimuli . Based on its etiology, em is classified into two types: primary and secondary em . Primary em...
Usher syndrome (ush) was first described by von graefe in 1858 and is characterized by the association of sensorineural hearing loss, retinitis pigmentosa (rp), and, in some cases, vestibular dysfunction . The syndrome is the most frequent cause of deaf - blindness, accounting for more than 50% of individuals who are b...
In olden days, mothers and babies were separated after birth to prevent infectious diseases and to keep newborns in a safe and controlled environment . The practice of rooming - in (keeping the mother and the baby in same room) started when it was realized that the separation had serious implications for the emotional ...
There are studies to examine proliferation and apoptosis associated biomarkers expressions in parathyroid lesions to reveal specific features . In this study, we evaluated the expression of some growth factors and their receptors in parathyroid gland of patients with sh or primary hyperparathyroidism (ph). Parathyroid ...
Patients and clinical assessment - this was a prospective cohort study conducted at joo paulo ii hospital (hjpii) of hospital foundation of minas gerais state (fhemig) from june 2010-june 2011 . The inclusion criteria were hospitalisation at hjpii, age 12 years old and laboratory - confirmed vl by one of the following ...
Electroless coatings have gained wide acceptance due to their excellent corrosion and wear resistance properties . Electroless coating, also known as chemical or autocatalytic coating, is a nongalvanic plating method that involves several simultaneous chemical reactions in an aqueous solution, which occur without the u...
This clinical trial study was conducted among children who volunteered for adenoidectomy in isfahan, the second large city in iran from may to december 2009 . The study population were comprised of 90 prepubescent children (45 normal - weight and 45 overweight children), aged between 4 - 10 years old, who volunteered f...
Dentinogenesis imperfecta (di) is described as a localized form of mesodermal dysplasia observed in histodifferentiation and corresponds to a congenital hereditary change involving deciduous and permanent teeth . Roberts and schonr were the first to use the term di, describing it as a condition similar to that found in...
Lung cancer is usually suspected in individuals who have an abnormal chest radiograph results or symptoms caused by either local or systemic tumor effects . Chest x - ray and computer tomography (ct) scans are widely used . Positron emission tomography (pet) additionally, it is used when doctors require more informatio...
It is well known that angiotensin ii (ang ii) mediates its physiological functions via two main receptor subtypes, the type 1 (at1r) and type 2 (at2r) angiotensin receptors where it has similar affinity for both the at1r and at2r . However, there is now increasing evidence suggesting that angiotensin peptides other tha...
The world health organization (who) defines malnutrition as the cellular imbalance between the supply of nutrients and energy and the body's demand for them to ensure growth, maintenance, and specific functions . Undernutrition could be primary (not consuming adequate calories, e.g., poverty, etc .,) or secondary (abno...
D(at)15-dna wrapped swcnts previously found to selectively detect nitric oxide in vitro were prepared and introduced to cultures of a375 melanoma cells (see supporting information methods). The swcnt concentration was quantified via absorbance spectroscopy, and a concentration of 2 g / ml was diluted into media for cel...
In this prospective, cross - sectional controlled study, a total of 200 consecutive children with iron deficiency and/or iron deficiency anemia were referred to the neurology and pediatrics departments of the medical faculty of bezmialem vakf university, istanbul, turkey between january and june 2013 . The ethics commi...
In the previous issue of critical care, zhao and colleagues applied a method based on electrical impedance tomography (eit) to help select the positive end - expiratory pressure (peep) that minimized ventilation inhomogeneities in healthy lungs . Several methods, including those based on global mechanics, arterial bloo...
Gallstone disease is very common in the united states and western europe with a prevalence of around 10% . However while mirizzi syndrome means compression of the common bile duct by a jammed gallstone in the cystic duct leading to biliary obstruction, bouveret's syndrome causes gastric outlet obstruction by a gallston...
Lfns ranging from 20 to 300 hz are emitted by a broad variety of sources including diverse means of transportation, in particular lorries, buses, trains, trams, airplanes, and helicopters; industrial machinery; stationary sources such as heating, cooling, and ventilation systems for buildings; compressors; and wind tur...
For decades, metal - porcelain restorations have represented the majority of tooth - colored laboratory - fabricated restorations due to their low cost when compared with metal - free restorations, easy cementation technique, and excellent clinical performance . As a result of the high cost of precious alloys and advan...
Myxomas are rare histologically benign tumors of mesenchymal origin, usually found in the heart . The left ventricle of the heart is the most frequent location, with the thigh and shoulder comprising other frequent soft tissue sites3). These tumors are locally aggressive and can be recurrent if en bloc resection is not...
Providing quantitative and accurate information for medical diagnosis, magnetic resonance imaging (mri) plays an essential role in medical imaging . Mri has several advantages over other medical imaging techniques regarding its multiple applications, namely, for cardiovascular, musculoskeletal, and, in particular, for ...
, des plaines, il, usa) are approved for the treatment of simple myopia and more recently for keratoconus and post - refractive surgery ectasia.1 the procedure is considered a simple and safe intervention; however it can still be associated with complications . Complications such as corneal perforation can occur intrao...
Eight long - term (> 10 months) ovariectomized shiba goats were used, and 4 of these animals were assigned to both groups . There was at least 5 months between treatment of goats with tak-683 in the treatment group and reassignment of the goats to the control group . The goats were fed a standard pelleted diet and dry ...
Bone metastasis is a source of significant pain, functional disability, and poor quality of life (qol) in patients with metastatic castration - resistant prostate cancer (crpc). Systemic chemotherapy, bisphosphonates, and radiation therapy (rt) are the effective measures of palliating symptoms associated with bone meta...
This treatment is commonly termed highly active antiretroviral therapy.1 saquinavir (sqv), as with other pis, exerts its pharmacological activities by binding to the active site of viral protease enzyme, leading to the formation of immature virus particles . Although sqv is highly effective in blocking hiv-1 infection,...
One of the problems in the scope of dentistry is postoperative complications; the most common ones are pain, bleeding, swelling and trismus . Precise assessment and control of these symptoms, especially pain, is very effective to gain patient's comfort.1 pain is a series of unpleasant psycho - physiological experience ...
Caecal tumors are rare but have insidious onset and cannot easily be diagnosed with barium enema and colonoscopy . The caecum is the dilated part of the right colon situated in the right iliac fossa . The etiology of tumor in this part of the colon may be similar to the tumor in the other parts of the colon . Colorecta...
According to results of the pre - census house count conducted in 2011, it is among the fastest growing megacities in the world and perhaps the fastest growing if measured by the annual increment in the population . Its estimated 2010 population of 15.4 million is projected to reach 18.04 million by 2015 . 9 per cent o...
Cell culture - h9c2 (2 - 1) cells [american type culture collection (atcc): crl-1446)] are an embryonic rat ventricular cell line . These cells were grown and maintained in dulbecco s modified eagle medium (dmem) supplemented with 10% foetal bovine serum (fbs) and 100 g / ml penicillin / streptomycin under an atmospher...
Developing new drugs has become an increasingly challenging, costly, and risky endeavor with a low success rate . The vast majority of drugs evaluated in clinical trials do not reach the market due to either a lack of efficacy or unacceptable side effects . Drug development is a fine balance of optimizing drug like pro...
Adequate treatment and support of these people is a major challenge for the health care system . Among the specific challenges, the early detection of symptomatic dementia as well as the integration of the patients into the existing structures the majority of people with dementia live at home1 and more than 99% of pati...
Idiopathic systemic capillary leak syndrome (iscls) is an extremely rare condition characterized by the triad of cyclical and episodic hypotension, hemoconcentration and hypoalbuminemia 1 . Iscls is a diagnosis of exclusion that without appropriate management has a significant morbidity and mortality 1 . We report a ne...
The resin - to - enamel bond following etching of the enamel surface with phosphoric acid was first described by buonocore in 1955 . It has been suggested that etching duration is a factor that can influence the bond to enamel [25], but the optimal enamel etching time varies depending on several parameters namely conte...
In recent decades, guided bone regeneration (gbr) procedures have been commonly performed to repair bone defect due to pathologic lesions or to augment alveolar bone for dental implant treatment . In the gbr procedure, the role of barrier membrane is crucial for proper bone regeneration . It can prevent in - growth of ...
Titanium and its alloys are regarded as one of the most promising materials for orthopedic biomedical implants and are considered as an alternative to conventionally used stainless steel due to their low elastic modulus, low density, higher corrosion resistance, and superior biocompatibility.1,2 the conventional ti-6al...
Muscle contraction and, therefore, all exercise are dependent on the breakdown of adenosine triphosphate (atp) and the concomitant release of free energy (1). This free energy release is coupled to the energy requirements of cell work, of which muscle contraction is just one example (1)atpatpaseadp+pi+energymuscle cont...
Diarrhea remains a major cause of mortality and morbidity in children up to 5 years of age in developing countries, where it ranks the first or second most common cause of death.12 preschool children in these countries have diarrhea for about 35 70 days each year3 and some studies4 have shown that they may have up to 3...
Alone, it accounts for 14% of global maternal deaths, with an estimated 36,698 maternal deaths in 2013 . This burden is disproportionate, as nigeria represents only 2% of the global population.1,2 although some improvements in the abysmal maternal mortality situation in the country have been recorded over the past 20 y...
A 37-year - old woman with diabetes mellitus visited the clinic to screen for retinopathy complaining poor vision . Right eye of the woman with circumferential iris ectropion (a), foveal hypoplasia (b), and absence of foveal avascular zone in fluorescein angiography (c). Left eye of the woman with circumferential iris ...
We present a case of acute gastric band slippage with gastric necrosis and massive haemoperitoneum necessitating an emergency laparotomy, gastrectomy and splenectomy . The patient had a swedish adjustable gastric band inserted laparoscopically using the pars flaccida technique several years earlier without complication...
Medulloblastoma is a malignant, invasive embryonal tumor of the cerebellum with preferential manifestation in children, accounting for 16% of all pediatric brain tumors and 40% of childhood cerebellar tumors . However, a purely extra - axial position at the cerebellopontine (cp) angle as reported in this paper is quite...
The evidence of dengue virus neurotropism and complications has been slowly rising over the last decade . Guillain barre syndrome (gbs), myelitis, acute disseminated encephalomyelitis, myositis, and neuropathy are relatively uncommon complications of dengue . Hypokalemic quadriparesis is a very rare complication in den...
A promoter database can be generated from a combination of genome sequence, information of promoter positions and a list of cis - regulatory elements . Currently a major restriction on the quality of a promoter database is our limited knowledge of cis - elements . There are several established genome - wide plant promo...
The recent publication of three meta - analyses has intensified the long - standing debate regarding the merits of colloids to expand the plasma space in critically ill patients . Two of these meta - analyses concluded that excess mortality was associated with the use of colloids generally and of albumin specifically, ...
Asthma is a chronic disease and is one of the major global health problems (1) which is characterized by inflammation of the airways, variable and recurring airflow obstruction, the airway walls swelling, mucus plug formation, and bronchial hyper responsiveness to physical and pharmacological stimuli (2). Different inf...
Transdural nerve root entrapment in the intervertebral disc space after incidental durotomy during lumbar disc surgery very rarely causes severe recurring radiating pain . There are several methods for the repair of dural tear including primary repair, tissue sealant, blood patch, and tissue grafting10). We have report...
Over the past decade, prescription drug misuse has increased significantly in the u.s . [1, 2] and is most prevalent among young adults 18 to 25 years of age [2, 3]. Prescription opioids, such as hydrocodone and oxycodone, are the most frequently misused class of prescription drug among young adults . Prescription opio...
Although, in 2010, malaria caused 660,000 deaths mostly among african countries, malaria mortality rates are gradually falling and have reduced by more than 33% in africa . In ghana, about 32.5% of all outpatient attendance and 48.8% admissions of children under the age of 5 are due to malaria . For decades, chloroquin...
Bowel problems, such as constipation and distension, occur in 27%62% of patients with spinal cord injuries . Acute abdominal pathology might be difficult to diagnose in a spinal cord injury patient due to its indolent course . Cecal volvulus is axial twisting that involves the cecum, terminal ileum, and ascending colon...
Myosin binding protein - c (mybp - c) is a regulatory and structural protein located in the a - bands of vertebrate striated muscle sarcomeres . The n - terminus of cardiac (c) mybp - c is important for mediating the regulatory functions of cmybp - c and is composed of 3 immunoglobulin (ig)like domains (c0, c1, and c2)...
The descend of testis from a temporary intra - abdominal site in fetal life to the permanent scrotal location after birth is crucial to spermatogenesis in mature testis . It is largely believed that disrupted endocrine regulation and several gene defects may play a role in the process . Nevertheless, the first phase of...
Cerebrospinal puncture is an important procedure for diagnosis of some critical conditions such as subarachnoid hemorrhage and central nervous system infections . Lp is routinely carried out with the patient in the supine or lateral decubitus position using two techniques . Traditional technique uses tuffier's line (an...
The laparoscopic roux - en - y gastric bypass (lrgb) is currently the preferred procedure in the management of severely obese patients . With increasing numbers of operated patients, late complications internal hernias are the main cause of late postoperative morbidity, causing abdominal discomfort and sometimes leadin...
Physical activity (pa) has been accepted internationally as an important factor for the protection and improvement of health in pregnant women as well as in the general population1 . Recent studies showed the beneficial effects of pa during pregnancy on the risks of gestational diabetes mellitus, preeclampsia, hyperlip...
Misfit at cementation38 results in open margins, increasing the risk of recurrent caries, plaque accumulation and periodontal disease . Several clinical and laboratorial procedures to improve crown seating have been described: chemical or internal relief of castings30,34, occlusal venting of crowns2,3,16,34, the use of...
Idiopathic inflammatory myopathies (iim) encompass three subsets: dermatomyositis (dm), polymyositis (pm), and sporadic inclusion body myositis (ibm) with distinct immunopathological patterns . In dm, complement deposition on endomysial capillaries, loss of microvessels, and mainly perivascular inflammation are observe...
Fresh leaves of a marmelos were collected from the botanical garden of guru nanak dev university, amritsar in the months of march - april, authenticated at department of botanical and environmental sciences, guru nanak dev university, amritsar and a voucher specimen is deposited in the herbarium of the same department ...
Phospholipids containing various polar headgroups and acyl chains are essential building blocks of biological membranes . Lamellar phospholipid bilayer structures have been widely studied with various experimental and theoretical techniques as a simple model for cellular membranes . Phospholipid molecules are composed ...
Coronary artery ectasia (cae) is defined as coronary artery dilatation with a diameter of 1.5 times or more than that of the adjacent normal coronary artery.1) but the incidence of multivessel coronary artery aneurysms (mcaa) among patients undergoing coronary artery angiography is very rare.2) as a matter of fact, all...
To explore new mothers' knowledge of newborn screening, and their attitudes towards issues surrounding sample retention and the potential for blood screening samples to be used for research . A self - administered mail survey was sent to women who gave birth in perth, western australia during january 2005 . It was foun...
Uveitis results from a wide variety of infectious and non - infectious insults, and it often presents a difficult challenge in terms of etiology and treatment . It is estimated that more than 280,000 people in the us are affected by uveitis each year, and it is responsible for up to 10% of all cases of blindness . Pati...
An important goal of community ecology is to illuminate the processes governing the assembly and coexistence of species (hardy, 2008). Because phenotypes are not randomly distributed with respect to phylogeny, we should expect a direct link to exist between the evolutionary relatedness of organisms in a community, the ...
Although pregnancy and childbirth are often viewed as periods of emotional well - being, the perinatal period is a time of substantial vulnerability to affective illness . Pregnancy is a period of great disruption and adjustment of biological, psychological and social aspects, which can be a risk factor for the develop...
Chronic kidney disease (ckd) is characterized by a progressive loss of renal function that often leads to end - stage renal disease (esrd), high risk for cardiovascular disease, and high mortality . Ckd is a growing global health problem due to increased prevalence worldwide . In the united states, the prevalence of ck...
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Meningoencephaloceles are defined as herniation of brain tissue through a defect of the skull and can be classified according to their location21). Common areas are occipital, cranial vault, fronto - ethmoidal and posterior fossa encephaloceles, while basal encephaloceles account for only 1.5% of cases6). The subgroup ...
An 83-year - old female patient was admitted with left knee pain and no history of disease . She had osteoarthritis in both knees and underwent bilateral tka . The left knee was replaced 23 years ago and the right was replaced 7 years ago . The radiograph showed severe femorotibial compartment narrowing in the left kne...
The proteasome inhibitor (pi) bortezomib is used as a first- and second - line treatment of multiple myeloma (mm) (anderson et al ., 2011). 2012) main function is to degrade ubiquitinated proteins in a controlled manner (bedford et al . Proteasomes are comprised of a cylindrical core particle (cp) capped at each end by...
Medullary thyroid carcinoma (mtc) is an undifferentiated, neuroendocrine tumor which arises from the parafollicular cells or ccells of the thyroid gland . The particular characteristic of this tumor is the production of calcitonin 1 as well as acth, histaminase, corticotrophin, vasoactive intestinal peptide, serotonin,...
Cancer and ischemic stroke share many risk factors that lead to increased risk of stroke in cancer patients . A report of autopsies performed on cancer patients indicated that 14.6% patients had evidence of pathological cerebrovascular disease and 7.4% had clinical symptoms of stroke.1 however, only 3.5% of cancer pati...
The data was collected from april to may, 2014 at orthopedic in - patient department of a tertiary care teaching hospital, guwahati, assam . The institutional ethical committee permission was taken to conduct this study (iec approval no . Patients who received analgesics in orthopedics ward during study period irrespec...
It is essential for embryonic development, proper segregation of chromosomes [1, 2], and a number of studies indicate it plays a role in both activation and repression of transcription [35]. Aberrant h2a.z expression may also play a role in some human diseases, since it has been demonstrated to play a role in cardiac h...
Mesenteric intra - abdominal cystic lesions have been recently classified on the basis of histopathological features . Cysts of mesothelial origin are rare lesions seen more frequently in young and middle - aged women, mostly benign and located in the mesenteries or omentum . What makes our particular case interesting ...
Staphylococcus aureus is a major cause of community - acquired and nosocomial infections, including localised and systemic life - threatening conditions, such as osteomyelitis, endocarditis, pneumonia, and septicaemia . Despite the increasing morbidity and mortality due to staphylococcal infections, relatively little r...
Herbal medicine is the oldest form of health care known to humanity and has been used in all cultures throughout history . Primitive people learned by trial and error to distinguish useful plants with beneficial effects from those that were toxic or nonactive . Even in cultures, tribal people methodically collected inf...
Treatment options using implants can be mainly divided into fixed types and removable types in edentulous patients.1 the appropriate type should be determined by considering the radiographic findings, the intra - oral examination, the diagnostic cast, and the patient's demand in the diagnostic stage, and by assessing t...
Modified bases in dna pose a severe threat for genome integrity, (figure 1). Dna could be directly damaged by environmental factors such as ionizing radiation, chemical mutagens or endogenous factors, such as oxidative stress and inflammation [24]. Many of these factors also damage nucleotides in dna precursor pools [5...
The genus caralluma (c.) belongs to the family asclepiadaceae (also known as the milk weed family) which comprises some 200 genera and 2500 species . The medicinal properties of c. species include antihyperglycemic activity of c. attenuata, while c. tuberculata also offered protection against mucosal damage of stomach ...
In 2011, four different categories of food products in france that were marketed by the food industry were identified as containing raw pork liver out sold to consumers to be eaten after cooking . These 4 categories were 1) figatellu and fitone, 2) dried salted liver, 3) quenelle and quenelle paste, and 4) dried or fre...
Ureteropelvic junction obstruction (upjo) corresponds to a dilatation of the pyelocaliceal cavities that appears before an obstacle located at the ureteropelvic junction, which causes an increased pressure in the kidney, hydronephrosis and progressive deterioration of renal function . It is considered the most common k...
Sarcomas are uncommon tumors, with <8300 new cases reported in the united states in 2001 . Sarcomas of the genitourinary tract account for <5% of these cases and <2% of all urological tumors . We herein review the literature and discuss how intratesticular leiomyosarcoma metastasized to the retroperitoneal space in thi...
Pure light chain deposition disease (lcdd) in kidney is classically described by the presence of nodular glomerulosclerosis by light microscopy, monoclonal deposits of light chains within renal basement membranes by immunofluorescence, and electron - dense, granular deposits along basement membranes by electron microsc...
Mucormycosis is a fungal infection with the following 5 classic forms: cutaneous, pulmonary, gastrointestinal, disseminated, and rhinocerebral . We present a case of a 38-year - old man with invasive mucormycosis that led to a basilar artery territory stroke . A 38-year - old man with a past medical history of diabetes...
Henoch - schnlein purpura (hsp) is a systemic small vessel, leucocytoclastic vasculitis with deposition of immune complexes containing immunoglobulin a (iga). Hsp is often considered the systemic form of iga nephropathy (igan), a common glomerulonephritis characterized by diffuse mesangial deposition of abnormally glyc...
The discovery and development of new drugs for the treatment of diseases is a lengthy and costly process . The drug development typically requires about 14 years, and studies demonstrated that by the year 2013 the cost to reach phase iii of clinical trials will be around $1.9 billion . Moreover, the number of drug appr...
A 45-year - old man of turkish extraction was referred to us for evaluation of hypokalaemia . Hypertension had been diagnosed about a year earlier and treatment with amlodipine 10 mg daily had been given . Serum potassium concentrations <2.5 mmol / l had been observed 3 months earlier that were not associated with hydr...