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The inheritance of various traits or diseases from parent to offspring occurs primarily through dna . When comparing two random human individuals, their dna is approximately 99.9% identical . The remaining 0.1% of dna is responsible for their differences (variations). The dna of an individual can change or become mutat... |
Zinc oxide (zno) is a ii vi semiconductor material with a wide bandgap of about (3.37 ev) together with a high exciton binding energy of (60 mev) both at room temperature rendering zno to receive global attention especially in connection with the emerging nanotechnology paces toward functionality . Zno nanostructures f... |
Arginine vasopressin (avp) is increasingly used in the management of refractory vasodilatory shock . Indeed, it was recently incorporated into the recommendations (grade iib) proposed by the american heart association for treatment of refractory septic shock and the guidelines of the surviving sepsis campaign (grade e)... |
Acute liver failure (alf), characterized by massive necrosis, is a syndrome defined by the onset of coagulopathy and hepatic encephalopathy and has a mortality rate ranging from 50% to 70% [16]. The prognosis of this disease has not significantly improved, despite the introduction of supporting treatments such as plasm... |
Organic micropollutants such as pesticides will only cause detrimental effects to organisms if they are taken up by the organism and can reach a target site where they can do harm . The processes of uptake, biotransformation, and elimination, also termed bioaccumulation or toxicokinetics, modify the concentration of or... |
As a service to our authors and readers, this journal provides supporting information supplied by the authors . Such materials are peer reviewed and may be reorganized for online delivery, but are not copyedited or typeset . Technical support issues arising from supporting information (other than missing files) should ... |
Mouse behaviors vary across the light / dark cycle (kopp, 2001; refinetti, 2006). In mammals, ambient light is the best known factor that regulates circadian timing, primarily through neurons in the suprachiasmatic nuclei (scn) of the anterior hypothalamus (menaker et al ., 1997; redlin and mrosovsky, 2004; reppert and... |
Photochemical reactions induced by irradiation with ultraviolet (uv) light are utilized in a large variety of applications such as surface cleaning, antiviral and bactericidal surface disinfection, air and water purification, photochemical surface modification, wettability alteration, material deposition, surface charg... |
The brain is particularly susceptible to oxidative stress due to its high rate of oxygen consumption, its high proportion of polyunsaturated fatty acids and its low levels of antioxidant defense enzymes . Consequently, the brain is a first - class target in situations in which free radicals are implicated such as agein... |
Atherosclerosis is an inflammatory disease which may be the outcome of responses to microbial antigens [1, 2]. Several conserved components of the bacterial cell wall have been shown to bind to receptors on the cell surface of monocyte and macrophages which may induce production of proinflammatory cytokines . The role ... |
A total of 780 nondiabetic caucasian subjects, consecutively recruited in the university of rome and the university of catanzaro areas, participated in this cross - sectional study for assessment of cardiometabolic risk factors according to a previously described protocol (17,18). The inclusion criteria were age 20 yea... |
The reported prevalence of gestational diabetes mellitus (gdm) varies widely between 1 and 14% of all pregnancies (1). This wide variation may be explained in part by ethnic differences, and also by a lack of consensus in screening for gdm (3, 4). Universal screening for gdm, for example, is practiced by 84% of obstetr... |
Interventionalists have recently experienced success in closing these defects using devices designed to close atrial septal defects or a patent ductus . Several complications of this procedure, including embolization of the devices to the descending aorta, are well documented . We report a case of embolisation of a dev... |
The population in korea is rapidly aging; the proportion of people aged 65 yr and older increased from 7.2% in 2000 to 11% in 2010 (1). According to an official prediction based on the population dynamics of fertility and mortality, 14.5% of koreans will be over the age of 65 in 2018, increasing to 20.8% by 2026 . The ... |
Most dorsal dislocation of the carpal scaphoid has been reported with axial dissociation of carpus or without other carpal injury.1234 complete dorsal dislocation of the carpal scaphoid associated with dorsal perilunate dislocation without axial dissociation of carpus is unique carpal injury which have not been reporte... |
Acute kidney injury (aki) is a common condition among critically ill patients in the intensive care unit (icu). Acute kidney injury results in rapid loss of kidney function and worsens the patient's prognosis . When severe, aki may necessitate the provision of renal replacement therapy (rrt); rrt can be applied through... |
A supernumerary tooth is a development anomaly of number characterized by the presence of tooth in addition to the normal series . Its prevalence rates of reported in the literature vary between 0.1% and 3.6% in the permanent dentition depending on the respective population . Supernumerary teeth can occur as singles, m... |
Asthma affects up to 12% of adults and 25% of children in australia and there is a significant undiagnosed cohort . Although we have a range of medications that are effective in their own right, there is a need to further improve the management of this disease . This involves better clinical programs and an improved un... |
The percentage of overweight and obese children and adolescents has increased and it is globally recognized as a serious health problem . Overweight and obese adolescents are at risk of getting chronic illnesses, and their mental health and self - esteem are affected as well . During adolescence, the frequency of parti... |
Benign paroxysmal positional vertigo (bppv) is the most common vertiginous disorder in the community . The cardinal symptom is sudden vertigo induced by a change in head position: turning over in bed, lying down in bed (or at the dentist or hairdresser), looking up, stooping, or any sudden change in head position . Whe... |
His best - corrected visual acuity (bcva) was 20/125 od and 20/20 os . Fundus examination od revealed prepapillary vascular loops with superotemporal macular branch vein occlusion (appearing as the sheathed vessel) and cystoid macular edema (cme) od [fig . 1]. The occlusion of branch retinal arteries was not obvious: s... |
Management of multiple sclerosis (ms) and decision - making surrounding pregnancy are complex subjects which includes the risk of relapse during pregnancy and post - partum, the use of disease modifying therapies (dmts) before / during pregnancy and breastfeeding, and the impact of breastfeeding on the course of ms . F... |
The aging process is typically characterized by a loss of muscular strength, reduction in joint mobility, reduction in cardiovascular capacity, and a decline in cognitive capacity.1 these physiological changes become more pronounced in postmenopausal women due to the development of osteoporosis and sarcopenia.24 these ... |
Patients presenting to the emergency department (ed) with undifferentiated chest pain or other symptoms suggestive of acute coronary syndromes (acs) account for 10% of all ed visits and present a diagnostic challenge . Acs, an umbrella term used to denote the spectrum of myocardial ischemia, includes unstable angina, n... |
Chrysanthemi flos (cf), the flowers of chrysanthemum indicum or c. morifolium, is rich in volatile oils, flavonoids and so on . Macrophages are main players in the immune function as antigen - presenting cells in initiating adaptive immune responses and in the innate immune response . Many studies have demonstrated tha... |
We have previously shown that c. elegans rab-11.1, a homolog of human rab11a, dynamically changes its localization and performs essential functions during the oocyte - to - embryo transition . To investigate the molecular mechanism by which rab-11.1 is activated, we searched for rab-11.1 binding proteins using a mutant... |
Asthma disproportionately burdens low - income african - american and hispanic children residing in inner cities such as the bronx, new york . The bronx, which is predominately hispanic, is the new york city (nyc) borough with the highest overall rates of asthma hospitalizations, deaths, and prevalence among children a... |
Stable and transient phenoxyl radical species are important in chemical processes spanning a large range of applications . Examples include tyrosine / tyrosyl radical mediated enzymatic electron transfers and hydrogen atom transfers, food preservation (such as butylated hydroxytoluene or bht), and fundamental studies o... |
Salmonellosis is a common foodborne disease caused by salmonella spp . And is of global significance . It is a significant pathogen of food producing animals and remains a primary source of salmonellosis 1 . Salmonella spp . Has been frequently reported in environmental samples since they find their way to the environm... |
The classically described presentation is of insulin - dependent diabetes, followed by optic atrophy, central diabetes insipidus, and sensory neural deafness . A 15-year - old boy with insulin - dependent diabetes was presented for evaluation of depressive symptoms associated with suicidal tendency . Neuropsychiatric m... |
Glaucoma drainage implants (gdi) are a useful modality in the management of intractable glaucoma cases . Late exposure of the implant tube through the overlying conjunctiva is a known complication of the surgical procedure . Untreated tube exposure seems to be a risk factor for endophthalmitis.1 gedde et al . Recommend... |
The muenke syndrome (ms) is an autosomal dominant craniosynostosis syndrome associated with a mutation in the fibroblast growth factor receptor 3 (fgfr3) gene located on chromosome 4p . The mutation, involving the fgfr3 gene, consists of a heterozygous nucleotide transversion, c.749c> g, encoding the amino acid substit... |
Tularemia has been a notifiable disease under the communicable diseases act in sweden since 1968 . Physicians who diagnose a case, either clinically or by microbiologic means, report to the county medical officer and the swedish institute for infectious disease control (smi). Cases were defined as tularemia in all pers... |
The major components of chromatin are dna and histone proteins, although many other chromosomal proteins have prominent roles, too . The functions of chromatin are to package dna into a smaller volume to fit in the cell, to strengthen the dna to allow mitosis and meiosis, and to serve as a mechanism to control expressi... |
In this work, e. coli wm2949 (23) with plasmid pjat8-arae (24) was used except when stated otherwise . In this strain, the chromosomal arafgh and arae genes were deleted and arae expression is controlled by a constitutive promoter on the pjat8 plasmid, thereby allowing homogeneous expression from the pbad promoter (23,... |
Prepare a substrate for fruit fly eggs to be parasitized by preparing agar (alternatively, gelcarin gp812, fmc biopolymer, ewing nj; a more cost effective option) filled dishes, 10 cm in length per side and 1.5 cm depth . Fill dishes to the rim with liquid agar (approximately 70ml), and allow them to cool and solidify ... |
According to traditional chinese medicine (tcm) theory, certain points on the body are linked together in a network of channels called tcm theory asserts that a smooth and adequate flow of qi defines health and suggests that the various characteristics of qi are determined by a complex set of interactions between exter... |
Obstructive sleep apnea syndrome (osas) is characterized by episodes of obstruction (partial or total) of the upper airway during sleep secondary to a collapse of the structures of the upper airway during inspiration . Osas manifests itself as a reduction (hypopnea) or complete cessation (apnea) of airflow despite cont... |
Temporary crown and fixed partial dentures are subjected to heavy and consistent loading by the mastication, and failure of the restoration frequently occurs . One of the common failure modes of the restorations which may lead to severe economic loss and patient discomfort is fracture.1 the materials used for temporary... |
It has been proven that interferon -1a can reduce relapse rate, disease activity [measured by magnetic resonance imaging (mri) scanning], and prevent disease progression [1, 2, 3]. Common side effects of interferon -1a include flu - like symptoms, headache, depression, insomnia, inflammation or cutaneous necrosis at th... |
The rotator cuff disease is known as one of the most common causes of chronic shoulder pain in adults, and its treatment is considered important because of the increased geriatric population and the advances made in medical diagnosis and treatment since the rotator cuff tear repair was first reported by codman in 1911 ... |
Cannabis sativa l. has been widely utilized by humans for thousands of years for the relief of a wide range of physiological ailments . In the united states, there are currently 18 different states and the district of columbia that legally allow for the medical use of cannabis, and most recently the states of colorado ... |
Liver dysfunction in a patient with triple - negative (estrogen, progesterone receptor - negative and her-2 neu negative) breast cancer due to liver metastases represents a potentially serious situation, especially when the patient is anthracycline resistant . Breast cancer in the setting of liver of liver metastases a... |
, many studies were undertaken to evaluate the short term changes, but in recent years the stability of orthognathic surgical procedures has been questioned on a long - term evaluation . Therefore, this study is intended to evaluate the stability and relapse of soft and hard tissues following mandibular advancement and... |
The most rapidly fatal and serious perforation of the gastrointestinal tract . Patients with esophageal perforations will often present with vague complaints, making the condition difficult to diagnose and potentially delaying the onset of treatment . Even with timely intervention, morbidity and mortality rates remain ... |
In order to isolate neuraminidase inhibitors, the fruiting bodies of p. igniarius were extracted using methanol for 2 days at room temperature . The methanolic extract was concentrated under reduced pressure, and the resultant residue was partitioned twice with ethyl acetate . The ethyl acetate - soluble layer was subj... |
The current classification of periodontal diseases includes accidental, iatrogenic, and factitious traumatic lesions . Traumatic lesions, whether chemical, physical, or thermal induced, are seen very common in the oral cavity . Although the prevalence of traumatic lesion on the gingiva is not known, it has been suggest... |
Patients with heart failure symptoms due to severe left ventricular (lv) dysfunction and coronary heart disease face a poor prognosis with limited functional improvement and medical treatment only leading to limited survival . Some of the causes of heart failure are myocardial infarction and other forms of ischemic hea... |
Cystic disease of the spleen is relatively rare, with an incidence of 0.07%.1 the splenic cysts categorized either as primary (true cysts) or as secondary (pseudocysts). The latter is mostly caused by abdominal trauma and has no epithelial lining in the cystic lumen . Additinoally, primary splenic cysts are further sub... |
Strokes of the left middle cerebral artery (lmca) territory often lead to impairments in language function that are collectively referred to as aphasias . Language recovery after lmca stroke is highly variable, and many patients remain chronically aphasic despite optimal rehabilitative approaches [2, 3]. Aphasia follow... |
In a case of acidosis induced by the administration of a mineral acid, such as hcl or nh4cl, acidemia itself increases serum k concentration . It is well known that hyperkalemia is caused by the release of intracellular k into extracellular fluid . In contrast, in animal experiments involving the administration of nonm... |
The potential for osteochondral defects to self - repair is limited in part due to the hypocellular and avascular nature of articular cartilage . Osteochondral defects that fail to heal spontaneously may ultimately result in further joint destruction and osteoarthritis . Numerous surgical treatment modalities have been... |
During the fifth week of gestation, ectodermal thickening is differentiated to form milk - line or mammary ridges on the ventral side, which are extended bilaterally from the axilla to the groin . Normally, these ridges persist in the pectoral region allowing for the development of breast tissue and regress in non - pe... |
This disorder is highly prevalent around the world, with an estimated 1015% of us adults suffering from tinnitus . Tinnitus is the number - one service related disability, with over 744,000 total veterans receiving disability compensation at a cost to american taxpayers over $2.26 billion in 2014 . The underlying etiol... |
High - quality images are crucial to accurately diagnose a patient or determine treatment . In addition to requiring the best images possible many imaging systems use x - rays to provide a view of what is beneath a patient's skin . X - ray radiation levels must be kept at a minimum to protect both patients and staff . ... |
Thalassemia major is a congenital defect of globulin chain synthesis, ineffective erythropoiesis and intense anemia . The chronic anemia leads to growth retardation, bone marrow expansion, extramedullary hematopoiesis, splenomegaly, greater intestinal iron absorption, hypercoagulability and higher propensity to infecti... |
Though well known, ruptured sinus of valsalva (rsov) aneurysms are rare comprising 0.3 - 3.56% of all congenital heart diseases.1 they are thin walled outpouchings of the sinus of valsalva and may be tubular or saccular in shape . The right sinus of valsalva is most commonly involved and usually ruptures into right hea... |
The survey used a random sample of 508 surgery residents from 7 (dandong, dalian, yingkou, chaoyang, tieling, fushun, and shenyang) of the 14 cities that constitute the liaoning province, covering the geographic diversity of the east, south, west, and north areas of liaoning province . The cross - sectional study was p... |
Adenoid cystic carcinoma (acc) of the breast is a rare condition, and cases in male patients are even less common . We describe a case of acc of the breast with axillary lymph node metastasis, disseminated osteolytic bone metastasis and bone marrow involvement in a 41-year - old man . Male breast acc is an extremely ra... |
A 15-year - old iranian girl was admitted to tehran pediatrics medical center, tehran (iran) in june 2006 . On admission also, she had submandibular soft - tissue asymmetry, night sweats, and proptosis (figure 1) and round shape painless patches on the arm and leg extensor surfaces (figure 2). A 15-year - old woman wit... |
In 1987, francine shapiro, a former english teacher, reportedly walked in a park, and noticed that unpleasant thoughts seemed to fade when she moved her eyes quickly back and forth (luber, 2009; rosen, 1995). Two years later, she launched a new treatment for post - traumatic stress disorder (ptsd), which is now known a... |
Malaria is among the leading causes of childhood mortality in guinea - bissau, comprising 18% of mortality of children less than five years of age as of 2010 (who, 2010). However, the human malaria incidence rate in guinea bissau varies considerably from year to year with a general decrease in recent years to about 3 c... |
Ampk, or 5'-adenosine monophosphate - activated protein kinase, is an evolutionarily conserved serine / threonine kinase that plays a crucial role in regulating energy homeostasis . In higher order eukaryotes, it is expressed in multiple systems and serves as an integrator of cellular and organismal energy balance and ... |
One of the best examples of how autocrine pdgf signaling contributes to malignancy is from studies of malignant gliomas . Co - expression of pdgf -receptor (pdgfr) and pdgf ligands are common in glioblastoma multiforme (gbm), and frequently associated with p53 loss . Enforced expression of pdgfr and pdgf - a confers gr... |
Anorectal malignancies are commonly adenocarcinoma or squamous cell carcinoma, with melanoma having a relative incidence of 0.54% of all malignancies in this region [1, 2]. This site is the third most common primary location for melanoma after skin and retina and yet only 0.41.6% of all primary melanomas arise here [2,... |
The participant of this study is a male subject (37 years old, 1.70 m, 67.40 kg and manual preference for right hand) with complete sensory - motor thoracic traumatic spinal cord injury (t9), ais a (american spinal injury association impairment scale) and with 3 years post - sci . He is a manual wheelchair user who is ... |
Periodontitis is a multifactorial disease with microbial dental plaque as the initiator of periodontal disease.1 however, the manifestation and progression of periodontitis is influenced by a wide variety of determinants and factors including subject characteristics, social and behavioral factors, systemic factors, gen... |
Even though laryngotracheal strictures that are due to inhalation injuries frequently occur, the current treatment options for this medical condition are limited . The management of laryngotracheal strictures that are caused by damage to the tracheal tissue from heat and intubation remains challenging . The acute treat... |
Age estimation is of great importance for the identification of victims of accidents and crimes . In case of living individual such as refugees and adopted children who have no acceptable identification documents, confirmation of chronological age postmortem age estimation involves analyzing the remains of bones and te... |
A model for the sequential generation of distinct cell types in the vertebrate cns . Neural stem cells (nscs) from the rat embryonic brain give rise to progenitors that are restricted to neuronal or glial fates . In vitro treatment of glial - derived precursors (grps) with members of the bone morphogenetic protein (bmp... |
Considerable clinical evidence suggests that renin - angiotensin system (ras) inhibitors (e.g., ramipril and benazepril) are beneficial as first - line agents for the treatment of hypertension in patients with chronic kidney disease (ckd) 1 - 4 . However, by themselves, ras inhibitors are unable to maintain an adequate... |
A 53-year - old man presented with a 10-year history of a nodule that had recently started growing and producing an itching sensation on the right occiput . A neck computed tomography scan suggested a benign soft tissue mass in the subcutaneous layer, so a local excision was performed . The tumor measured 2.61.71.5 cm,... |
The first land plant rooting structures comprised systems of tip - growing filamentous cells (rhizoids). Comparing the genetic mechanism that controls the development of filamentous rooting cells (rhizoids and root hairs) among different groups of land plants allows us to reconstruct the mechanism that controlled the d... |
These are usually patients who are seriously ill with sepsis or children and adults with cardiovascular infections and paucibacillary disease . Appropriate antibiotic treatment is based on isolation, identification, and antimicrobial susceptibility pattern of an organism isolated from blood culture . The conventional b... |
Osteosarcoma constitutes a small percentage of rare malignant non - epithelial neoplasms of the thyroid, and has been reported in only several dozen cases . One of the conclusive tests is immunohistochemical staining, which excludes epithelial differentiation of the tumour . We present a case of a female patient who un... |
We enrolled 181 type 2 diabetic subjects using the following inclusion criteria: 1) ages> 35 and <75 years, 2) serum creatinine levels less than 1.4 mg / dl and albumin excretion rate less than 300 mg / day, 3) hepatic enzymes levels less than three times upper normal, and 4) alcohol consumption less than 20 g / day . ... |
Gait refers to moving the body to targeted points using the legs as a complex and integrated activity with low energy consumption involving alternative and harmonious movements with normal tension of the antigravity muscles1 . During gait, the smaller the step length difference (sld), stance phase difference (stpd), sw... |
Lupus nephritis (ln) is characterized by immune complex deposition and inflammation in glomeruli and the tubulointerstitium, but its precise pathogenesis is not very much clear until now . Many studies have indicated that systemic loss of b - cell tolerance results in the local deposition of immune complexes [1, 2]. Wi... |
The prevalence of obesity in the united states has reached epidemic proportions and continues to rise . Numerous harmful sequelae of obesity including increased cardiometabolic risk and overall mortality have been demonstrated . Variations in body fat distribution, independent of generalized adiposity, may be associate... |
Transmembrane transport proteins often function in conjunction with auxiliary proteins that facilitate their vectorial activities [1, 2]. These proteins are the membrane fusion proteins (mfps; transporter classification number (tc #) 8.a.1 in the transporter classification database (tcdb; http://www.tcdb.org/), which f... |
Periodontitis is an immune - associated inflammatory disease of the periodontium characterized by progressive destruction of the supporting tissues of teeth . It can destroy the surrounding connective tissue and adjacent alveolar bone and eventually causes tooth loss [2, 3]. The immune and inflammatory responses that a... |
Hyponatremia and an increased production of urine are frequently observed after calvarial remodeling in patients with craniosynostosis . Hypoosmotic conditions result due to sodium loss in the body when these symptoms are not corrected appropriately, leading to dysfunctional cerebral blood flow, circulation problems, c... |
Genetic nature of allergy and complex mechanisms governing the development of atopic phenotype already in fetal life have since long been recognized . The process of hypersensitization begins synchronously with the initiation of fetal production of immunoglobulin e in the 11th gestational week . The ige level in umbili... |
Hepatitis c virus (hcv), a worldwide blood borne infection with a global importance, is a significant cause of hepatic diseases, cirrhosis and hepatocellular carcinoma, after hepatitis b which its screening was introduced in blood banking laboratory methods (1 - 5). Chronic infection with hcv is a major cause of liver ... |
All of the subjects who were consecutively observed in the outpatient unit of the pediatric department of pozzuoli hospital in the period between 2004 and 2010 were included in the study . The majority of the children were referred by their general practitioners for allergy problems, overweight, and obesity, as describ... |
Nineteen healthy men (mean sem age 23.2 0.6 years and bmi 23.5 0.3 kg / m) who were free of medication participated in the experiments . They gave written informed consent to the study, which conformed to the declaration of helsinki and was approved by the local ethics committee . Each subject participated in two condi... |
People with intellectual disabilities comprise an estimated five million persons in the eu 27 member states . Evidence suggests that people in this group show negative disparities in health status and in access to optimal health care . They are more likely to incur secondary health conditions and thus report increased ... |
A seizure is a transient disturbance of the cerebral function secondary to abnormal paroxysms in the brain, which results in a sudden excessive disorderly discharge of the cerebral neurons . The discharge results in an almost instantaneous disturbance of sensation, loss of consciousness or psychic function, convulsive ... |
Malignant liver tumors are considered to be one of the major public health problems in the world because of late diagnosis and failure of treatments . There are mainly three kinds of malignant liver tumors in adults: hepatocellular carcinoma (hcc), cholangiocarcinoma (cca), and metastatic liver tumors . Approximately 5... |
Economic evaluations are increasingly used to inform decisions regarding the allocation of scarce health care resources . They generally take the form of cost - utility analysis, in which incremental costs per gained qaly (quality - adjusted life year) are evaluated against some threshold to ascertain the intervention ... |
Since, this gamma radiation is potentially harmful to the body, it is essential that minimum (as low as reasonably achievable [alara]) radiopharmaceutical dose be administered . Another important requirement for a diagnostic radioisotope imaging is that the patient remains static during data acquisition . However, this... |
The kidney is an organ for metabolism and elimination of ths and a target of some of the iodothyronines actions . Thyroid dysfunction may effect on glomerular and tubular functions and electrolyte and water (h2o) homeostasis . It may cause a reduction in glomerular filtration, hyponatremia, and h2o excretion alteration... |
In contrast to the common finding of mucin production in non - endocrine epithelial tumors or mucinous metaplasia, in endocrine tumors it is an unexpected rare finding.1 mucin is rarely encountered in the primary thyroid neoplasm and only occasionally has mucin production been reported in medullary carcinoma or poorly ... |
Cleft palate is a frequent congenital defect, with an incidence of 1 per 700 to 1,000 live births . The patients experience several problems in speech, feeding, dentition, maxillofacial growth, health status of the middle ear, and social relationships . The paramount issues aimed at in the treatment of the cleft palate... |
World health organization estimated that 17.5 million of people die from cardiovascular diseases (cvd) each year constituting 31% of all deaths worldwide . Among the cvd deaths, the evolution of treatment modalities and the intense public health preventive efforts has reduced the influence of smoking, untreated hyperte... |
Recently, there has been a shift in focus from individuals deficits to exploration of their strengths . A study of the history of nursing shows that human strengths have been addressed in some nursing theories . However, these theories are based on a deficit model rather than on improving the strengths and well - being... |
Electron paramagnetic resonance (epr) spectroscopy, when combined with detailed computer modeling, is a powerful and valuable tool for oligomeric protein complex structure determination and can be used to probe structural details for these protein assemblies in the many situations where x - ray crystallography or nmr s... |
One of the goals of the program is to support research projects that include one of the following objectives: identify health risks including those affecting vulnerable peoples, analyse the risks to health, and/or conduct a health risk assessment, and examine exposure and/or modelling data collection . Proposals must a... |
The online version of this article (doi:10.1007/s00228 - 014 - 1660 - 7) contains supplementary material, which is available to authorized users . Given limited sample sizes, short duration, and lack of generalizability of preapproval clinical trials, a drug s safety profile at the time of regulatory approval is often ... |
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