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A variety of bacterial pathogens are responsible for causing urinary tract infections (utis), but the most prominent are escherichia coli, enterococcus spp ., pseudomonas aeruginosa and mirabilis, klebsiella pneumoniae, candida albicans, enterobacter spp ., and coagulase - negative staphylococci . However, it is the ur... |
Reversible cerebral vasoconstriction syndrome (rcvs) has been reported to occur in various clinical settings . Although it may occur spontaneously, various associated conditions have been described, e.g. Uncontrolled hypertension, pheochromocytoma, pregnancy or puerperium (postpartum angiopathy), neurosurgical procedur... |
Natural background radiation originates mainly from uranium radium, uranium actinium, thorium series elements and radionuclide 40k, as well as from nuclear transformations of such gases as nitrogen, oxygen or argon under the influence of highly energetic cosmic radiation [1, 2]. Activity concentration of natural radioa... |
231090) is an aberrant human pregnancy in which there is nonexistent or abnormal embryonic development, excessive trophoblastic proliferation, and cystic degeneration of chorionic villi into grape - like structures . The common form of hm is sporadic, not recurrent, and affects 1 in 600 pregnancies in western countries... |
Uveal schwannomas, previously known as spindle cell tumor of blueeyed dogs (sctbed), were first described by zarfoss et al . In 2007 1 . These tumors develop in the anterior uvea of dogs with blue iridal tissue; however, limited literature is available with 2 one case report of uveal schwannoma exists occurring in the ... |
A key component of most malaria control strategies is effective control of the mosquito vector . Indeed the world health organization supports vector control as the most generally effective measure to prevent malaria transmission and promotes a strategic approach to vector control known as integrated vector management ... |
Corneal furrow degeneration is painless, bilateral thinning of peripheral cornea between corneal arcus and limbus, predominantly affecting elderly . Commonly, there is no inflammation, vascularization, or induced corneal astigmatism . Conjunctival squamous cell carcinoma in situ (cis) of conjunctival epithelium is a ma... |
Insulin therapy is still the gold standard in the treatment of diabetes in pregnancy when medical nutrition therapy (mnt) and lifestyle cannot reach and maintain the metabolic targets [1, 2]. Studies using lispro and aspart in pregnancy have shown that both rapid - acting insulin analogues are safe and effective in red... |
Ocena efektywnoci poredniej wenografii tomografii komputerowej (computed tomography venography ctv) stosowanej po pucnej angiografii tomografii komputerowej (computed tomography angiography cta) u pacjentw z podejrzeniem zatoru pucnego . U wszystkich pacjentw kolorow ultrasonografi dopplerowsk (color doppler ultrasonog... |
Accessory spleen (as) may develop during the sixth week of embryogenesis following the deposition of spleen cells along the path from the midline, usually occurring on the left side . An as is commonly located near the spleen s hilum and in the pancreas tail, and is generally asymptomatic and diagnosed incidentally dur... |
The material employed for sealing is one of the important factors for prognosis that directly interfere with the repair of these defects4 . However the divergent outcomes have demonstrated that so far no ideal sealing material has been achieved, i.e. A material that may provide optimal sealing, easy manipulation, bioco... |
Band cementation is customarily performed during orthodontic treatment to improve fixed appliances anchorage and retention in posterior teeth, since the use of brackets may be related to an increased risk of premature debonding at that region . Besides the need for long - lasting retention for fixed appliances, other a... |
Uterine fibroids, also known as leiomyomas, myomas, or fibromyomas, are the most common benign uterine neoplasms associated with significant morbidity of nearly 40% in women during their reproductive years . Typical symptoms related to uterine fibroids, including abnormal menstrual bleeding, dyspareunia, non - cyclic p... |
Physicians treating newly incapacitated patients often must help navigate surrogate decision - makers through a difficult course of treatment decisions . Because safeguarding the patient's autonomy often requires open discussion of the patient's condition with appointed surrogates, physicians have ethical duties to pro... |
Upper extremity transvenous access is the method of choice for implantation of cardiac implantable electronic devices (cied). However, venous access for many patients can be challenging and not achievable due to vessel occlusion . The most common cause of venous occlusion is prior instrumentation,,, . In patients requi... |
Periodontal disease is the most prevalent disease with a multifactorial etiology, affecting a large population worldwide . Plaque, being the primary etiologic agent, a constitutional factor, probably of genetic origin, may play a part . Hence, it is interesting to emphasize the significance of genetic factors in patien... |
In a differential diagnosis of a wide complex tachycardia (wct), prior to which a 12-lead surface electrocardiogram (ecg) was taken, a comparison of qrs morphology between the sinus rhythm and the wct is helpful . An identical qrs morphology between sinus rhythm and wct strongly suggests supraventricular tachycardia (s... |
Infertility is usually defined as the failure of a couple to conceive after trying to do so for at least one full year (1). Moreover, according to the definition introduced by the world health organization, quality of life is defined as individuals perception of their position in life in the context of the culture and ... |
Specification of centromeres on metazoan chromosomes appears to involve both dna sequence determinants and epigenetic factors such as chromatin structure and replication (harrington et al . 1997; karpen and allshire 1997; ikeno et al . 1998; murphy and karpen 1998). Although human centromeric alpha - satellite dna is a... |
Eosinophilic gastroenteritis (eg) is a rare disorder that can present with various gastrointestinal manifestations, depending on the site and layer(s) of the gastrointestinal tract involved [1, 2]. Patients with mucosal layer involvement may present with dyspepsia, abdominal pain, diarrhea, iron deficiency anemia, mala... |
Dna sustains damage through exposure to chemicals, uv light, ionizing radiation, chemotherapy, or products of cellular metabolism . Single - strand breaks are faithfully repaired through base excision, nucleotide excision, or mismatch repair . Double - strand breaks are repaired by homologous recombination (hr), a proc... |
In recent years, the survival rate from outofhospital cardiac arrest (ohca) in industrialized countries has increased because of major advances in cardiopulmonary resuscitation (cpr).1, 2, 3, 4 however, the mortality rate remains high, and the survival to hospital discharge rate among ohca patients is between 7.2% and ... |
Enterohemorrhagic escherichia coli (ehec) o157:h7 initially was identified as an important human pathogen in the united states, and this pathogen recently has become the most prevalent type of enterohemorrhagic e. coli (ehec). Ehec is a cause of infection worldwide in both human and animals (17). E. coli o157:h7 is a f... |
The online version of this article (doi:10.1007/s10554 - 010 - 9687-z) contains supplementary material, which is available to authorized users . Due to differences in culture, healthcare systems, ethnicity, socioeconomic status and disease prevalence [3, 4], existing guidelines for cardiac computed tomography (ct) and ... |
Early studies of craniofacial growth used conventional craniometry, the measurement of dry skulls as conducted by anthropologists . The development of biometry allowed the direct measurement of the living body, but also had limits, as the soft tissues caused measurement errors that prevented accurate measurement of the... |
Goodpasture's disease is an autoimmune disorder characterised by the development of autoantibodies to the nc1 domain of the 3 chain of type iv collagen, found in glomerular, pulmonary, and other basement membranes . Clinical presentation comprises rapidly progressive crescentic glomerulonephritis and pulmonary haemorrh... |
Dry eye disease (ded) is a complex, multifactorial condition characterized by inflammation of the ocular surface and lacrimal glands and reductions in the quality and/or quantity of tears.1 the prevalence of ded is high and ranges from 5% to 33% of the adult population worldwide.2 ded is considered to be a symptomatic ... |
Tooth avulsion is the complete displacement of a tooth from its socket as a result of trauma[1 - 2] the reported incidence of complete avulsion ranges 1 - 16% of all traumatic injuries to the permanent dentition . The prognosis of a replanted tooth depends on the existence of viable periodontal ligament cells on the ro... |
The exact etiology of hwws is still unknown, but it may be caused by the abnormal development of mllerian and wolffian ducts . Herlyn - werner syndrome (i.e., renal agenesis and an ipsilateral blind hemivagina) was initially described in 1971 by herlyn and werner . In 1976, wunderlich described an association of right ... |
Ectopic acth secreting tumors constitute 15% of cushing's syndrome, usually presenting with rapid onset and progression of the disease . Lung carcinomas, and bronchial, thymic, and pancreatic carcinoids are the most common tumors associated with this disorder . A 29-year - old gentleman presented with recurrent episode... |
Preeclampsia (pe) is defined as the onset of hypertension and proteinuria after 20 weeks of gestation in previously normotensive nonproteinuric pregnant women . Poor placental perfusion along with the endothelial cell dysfunction and a disturbed balance of angiogenic factors may all contribute to this disorder . It is ... |
Common bile duct (cbd) is a rare site for foreign bodies (fb). Most reported cases in the literature are on sutures, surgical clips and stents found in the cbd, after previous surgical procedures . Some fish bones were believed to have entered the cbd retrogradely, whereas others had evidence of penetration through the... |
We conducted a retrospective cohort study to examine rates of screening for diabetes among immigrants to canada compared with those in the general population during the 3-year period from 1 april 2004 (the baseline date for this study) to 31 march 2007 . To do so, all adults aged 40 years or older (based on canadian sc... |
Tinnitus is a condition in which the individual perceives a sound in the ears or in the head in the absence of outside sounds . A multidisciplinary approach should be used for the treatment of tinnitus as its physiopathology is not fully understood and it seems to be related to disorders of the outer, middle, or inner ... |
It is well recognized that pain perception as well as pain relief after analgesic treatment display, large interindividual variability in the population that affects selection of analgesics and their dosing in the population . Age, gender, ethnicity, and actual level of stress, mood, or diseases may modify individual p... |
Intracranial acc is even more infrequent and could be primary or secondary, occurring either by direct invasion, hematogenous spread or perineural spread . We report cytodiagnosis of lacrimal gland adenoid cystic carcinoma, metastatic to the calvaria, epidural compartment and brain parenchyma . A 61-year - old male pre... |
Indeed, the major causes of endodontic treatment failure are incorrect canal instrumentation, incomplete canal obturation, and untreated major canals . Additional canals may be detected by clinical investigation of the floor of the pulp chamber and radiographic examination of the roots . The maxillary first premolar ty... |
The incidence of acute myocardial infarction (ami) in very elderly patients is increasing due to rapid ageing of the population, which is expected to be more noticeable in the coming years . Atrial fibrillation (af) is a common finding in patients who have ami and becomes more frequent with age . The incidence of af am... |
Intraosseous hemangioma (ih) is a rare benign neoplasm amounting for 0.5% to 1% of all skeletal benign tumors and having an uncertain origin . Intraosseous hemangioma is considered as a hamartomatous malformation or a true endothelial tumor with production of blood vessels . The maxillofacial district is only occasiona... |
Lacrimal gland secretion is primarily under neural control, which is achieved through a neural reflex arc functioning as an integrated or functional unit.8,12 stimuli to the ocular surface activate afferent sensory nerves in the cornea and conjunctiva . This stimulus then goes to the central nervous system in the area ... |
Caffeine is one of the most commonly consumed drugs throughout the world and has minimal health risks (10). Since caffeine can be found in many foods and drinks, its effect on the body and cardiovascular system should not be overlooked . Caffeine has been shown to improve mood, enhance psychomotor performance, enhance ... |
During pregnancy, two genetically different organisms, the mother and the fetus, establish a molecular cross - talk [13]. In this cross - talk, a huge number of molecules are secreted by both organisms and act on both sides . The concerted action of endocrine, paracrine, and autocrine molecules makes the maternal decid... |
The starlet sea anemone, nematostella vectensis, is a member of the basal metazoan phylum cnidaria . This species is emerging as an important model system in evolutionary genomics, developmental biology and estuarine ecology due to (i) the availability of a complete genome sequence, (ii) the generally conservative evol... |
Cardiovascular diseases are the most common reason of morbidity and mortality worldwide (1). In the western countries they account for almost 17 million deaths; in developing countries their occurrence is becoming important along with industrialization, urbanization and changing life styles (2). Cardiovascular disease ... |
Reconstruction of the anterior cruciate ligament (acl) is recommended for prevention of instability, further intraarticular disease, and recurrent injury in the acl - deficient knee [13]. A semitendinosus (st) or combined st and gracilis (stgr) tendon graft is commonly used for reconstruction of the ruptured acl . Eval... |
This cross - sectional study used pooled dataset from nine hdss sites in five asian countries namely matlab, mirsarai, abhoynagar and watch (bangladesh), kanchanaburi (thailand), filabavi and chililab (vietnam), vadu (india), and purworejo (indonesia). The choice of these hdss sites (and countries) happens to arise fro... |
Infertility is relatively common among young couples (1015%) where, 4550% is due to female factor, 3040% results from male factor, and the remaining of cases (1030%) is idiopathic (1). One of the treatments of idiopathic infertility is ovulation induction followed by intrauterine insemination (iui) (2). Evidence sugges... |
Cd8 t cells play a major role in protective immunity to a wide variety of pathogens, including viruses, bacteria, and protozoan parasites . However, the protective role of cd8 t cells during leishmania infections has been controversial, mainly because of the discrepancy among infections with different leishmania specie... |
Pd is a common neurodegenerative disorder characterized by the motor features of rigidity, tremors, akinesia, and changes in speech and gait which are associated with the loss of dopaminergic neurons in the substantia nigra pars compacta and the subsequent deficiency in striatal dopaminergic system . It has prevalence ... |
Osteoporosis is a common metabolic disease in the elderly and is closely associated with patient age . Recent studies have shown that an age - related decrease in intestinal calcium absorption is closely related to senile osteoporosis and bone loss1 . A lack of exercise among the elderly is also an important factor in ... |
Non - human primates (nhps) often serve as reservoir of pathogens of human diseases . The yellow fever virus (ellis and barrett, 2008), chikungunya virus (mccrae et al ., 1971; labadie et al ., 2010), and the protozoa giardia lamblia that cause diarrhea (kowalewski et al ., 2011), are all examples of pathogens that ori... |
Foot - and - mouth disease (fmd) is a highly contagious viral disease of cloven - hoofed animals, both domestic and wild . The disease is caused by fmd virus (fmdv), which is one of two species in the genus aphthovirus in the family of picornaviridae, an important group of mammalian rna viruses . Fmd has been endemic i... |
It is well known that chronic inflammation is involved in pathogenesis of many chronic diseases such as insulin - resistance diabetes, vascular diseases, atherosclerosis, neurodegeneration and cancers (1, 2). As well as, recent investigations suggest that these chronic inflammation - related diseases may be postponed o... |
The atac trial evaluated the efficacy and safety of anastrozole vs tamoxifen given for 5 years in postmenopausal women with localized breast cancer (11). The transatac study collected formalin - fixed, paraffin - embedded blocks from hormone receptor positive breast cancers in a subset of women randomized to the monoth... |
Rocket af was a multicentre, randomised, double - blind, double - dummy, trial comparing fixed - dose rivaroxaban with adjusted - dose warfarin (target international normalized ratio 2.03.0) for prevention of all stroke (ischaemic or haemorrhagic) or systemic embolism . The study randomized 14171 patients from 1178 cli... |
During a routine outpatient visit for dysfunctional voiding and reflux nephropathy, an 11-year - old girl reported recurrent colicky flank pain in the left loin, which had started several weeks before . There was no macroscopic hematuria or passage of a kidney stone, and the voiding pattern, after treatment of the void... |
Hepatic sinusoidal obstruction syndrome (sos), formerly known as veno - occlusive disease, is a life - threatening syndrome [1 - 3]. Sos generally occurs as a complication after high - dose chemotherapy associated with hematopoietic stem cell transplantation (hsct). While sos in patients undergoing hsct is life - threa... |
In general, a plant extract contains low concentrations of active compounds and a large number of promising but undiscovered compounds . A widely observed and accepted fact about the medicinal value of plants is mainly the bioactivity of the phytocomponents present in it . Although a major effort towards of the elucida... |
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
Cytochrome p450 (cyp450) is a superfamily of isoenzymes involved in energy conversion in biological organisms . It has been shown that the metabolism of a number of drugs, including platelet aggregation antagonists, proton pump inhibitors, anti - diabetes drugs, and anti - cancer drugs, all depend on this enzyme . The ... |
A 63-year - old male patient presented with complaints of gradually increasing misalignment of the eye, ocular deformity, headache and pain in the left eye approximately for 5 years . At physical examination, an asymptomatic left eye was detected excepting proptosis (figure 1). Neurological examination revealed restric... |
They usually start off with a light tan and then may darken to dark brown or nearly black . The consistent feature of seborrheic keratoses is their waxy, pasted - on or stuck - on look . The lesions can appear anywhere on the body, but most often occur on the face, chest, and back . We report a raindrop and stream patt... |
Systemic lupus erythematosus (sle) is a complex disease that's characterized by an autoantibody response to nuclear and cytoplasmic antigens . The autoantibody response is associated with the inflammatory cascades and end - organ damage in the kidney, skin, brain and other organs . Especially in the kidney, immune - co... |
Pranayama, the fourth limb of classical ashtanga yoga is an essential part of yogabhyasa and is increasingly being used as a tool of yoga chikitsa or the application of yoga as a therapy . There are a multitude of pranayama techniques and it is traditionally taught that each of them has different psycho - physiological... |
Parkinson disease (pd) is an age - related disorder characterized by a progressive degeneration of dopaminergic (daergic) neurons of the substantia nigra pars compacta (snc). The etiology of daergic neurons death is not known . However, reported data suggest oxidative stress as the probable candidate to mediate in the ... |
Human immunodeficiency virus (hiv) prevalence among adults in the caribbean is estimated at 1.0% which is second to sub - saharan africa.1 the joint united nations programme an hiv / aids (unaids) estimated that at the end of 2009 in a population of 33 million, there were 240,000 people living with hiv in the caribbean... |
Transplantation of pancreatic islets containing the insulin - producing beta cells could in principle cure type 1 diabetes . However, transplantation of allografts necessitates treatment with immunosuppressant drugs with ensuing side effects . Encapsulation of islets (or isolated beta cells) could potentially alleviate... |
Is quite significant in terms of age and sex determination, personal identification of unknown deceased persons, analyzing bite marks as evidence, participating in mass disaster, giving evidence in child abuse, etc . Cheiloscopy (from the greek words, cheilos = lips, skopein = see) or the study of lip prints, which is ... |
Stable angina is a common and disabling disease, and occurs when there is regional myocardial ischaemia caused by inadequate coronary perfusion due to chronic coronary obstruction . Despite the fact that william heberden gave a clear description of stable angina as early as 1768, the optimal strategy for diagnosis in s... |
Mikulicz's disease (md) is a chronic inflammatory disease characterized by diffuse enlargement of the lacrimal and submandibular glands, elevated levels of serum immunoglobulin (ig)g4, and abundant infiltration of igg4-positive plasmacytes and fibrosis in both glands . Md is considered as an igg4-related disease (igg4-... |
Marginal zone b - cell lymphoma of the mucosa - associated lymphoid tissue (malt lymphoma) of the lacrimal sac is a quite rare cause of the lacrimal duct obstruction [1, 2]. Typically, this entity initially presents with epiphora, followed by dacryocystitis and/or a palpable mass . A lack of specific symptoms may resul... |
Meningiomas, unlike the case of the adult population, account for less than 5% of intradural extramedullary spinal cord tumors3,12). These rare lesions tend to occur in the cervical or thoracic region in children10). The recognition and complete excision of these tumors are very important in view of their benign nature... |
T has been known for several decades that enzymes, such as those of bacterial, plant, and fungal origin, have the potential to cause occupational respiratory allergy, even asthma, depending on exposure levels and conditions . As a direct consequence, it is necessary to control occupational exposure to enzymes so that t... |
Systemic fungal infections are especially dangerous because they are associated with a high mortality rate, which reflects the low efficacy and multiple side effects of current antifungal drugs as well as the emergence of strains resistant to current therapeutic agents . Pathogen resistance to fluconazole is widespread... |
Stable activity - dependent changes in synaptic efficacy, as seen during long - term potentiation (ltp) and long - term depression (ltd), require new gene expression . Persistent changes of this kind are thought to underlie long - term adaptive responses in behaviour, including memory formation, motivation, mood, and p... |
The use of indices predicting weaning outcomes can reduce the risk of weaning failure and complications posing potential morbidity, such as reintubation . Weaning indices are used in order to evaluate lung mechanics and can provide information regarding the causes of mechanical ventilation (mv) dependence . It is curre... |
Sleep - disordered - breathing (sdb) is a group of common disorders characterized by habitual snoring along with varying degrees of gas exchange alterations and sleep fragmentation . Obstructive sleep apnea (osa) is the most prevalent of those disorders affecting 14% of children with a peak incidence around 28 years . ... |
Allergic rhinitis (ar) is a common chronic illness affecting 10% to 20% of the children worldwide, and its prevalence has significantly increased among children over the last two decades . Ar is clinically defined as a symptomatic disorder of the nose induced by an ige - mediated inflammation after exposure to an aller... |
, systematic reviews have shown that scientific evidence is scarce [2, 3]. In fact, evidence on beneficial effects, such as improved adherence, is inconsistent [4, 5]. On the contrary, recent research has indicated safety concerns regarding the prescribing of drugs to patients within such systems . For example, patient... |
Genomic dna was extracted from bone marrow/ peripheral blood samples from healthy donors and patients with mds, mds / mpn, primary and secondary amls . Clinical features and other detailed information pertaining to the patient samples genomic dna was treated with sodium bisulfite using the epitect bisulfite kit (qiagen... |
The study population included all persons in toronto for whom active tb had been reported to toronto public health from january 1, 1998, through december 31, 2007 . Data were extracted from the reportable disease information system and the integrated public health information system for all case - patients with a risk ... |
It causes illness by the ability of the causative parasite to invade the red blood cells and the liver where they multiply . In extreme infections, up to 80% of the red blood cells this massive cell destruction is known to lead to severe anaemia and clogging of the blood circulation of vital organs particularly the bra... |
The lumbar facet joint provides stability of the spinal motion segments against shearing, rotation, and flexion forces . The biomechanical role of the facet joints includes supporting 33% of the dynamic compressive load and 35% of the static load of the spine.1 2 disruption of the facet joint function by degenerative p... |
Huntington's disease (hd) is a neurodegenerative disorder that causes a triad of cognitive, motor, and psychiatric symptoms . It strikes persons in the prime of their lives, has an adverse impact on quality of life (qol), and causes untold disability and suffering in patients and their loved ones [24]. If a parent has ... |
Open reduction and internal fixation is the standard treatment for acetabular fractures displaced more than 2 mm.1 poor reduction of the acetabular joint surface foretells poor function of the affected hip joint.1 until date, the treatment of complex acetabular fractures remains a challenge even to the experienced trau... |
Although the main characteristic of people with intellectual disabilities is impairment of intellectual ability, some studies have also noted significantly poorer motor nerve systems, sensory integration, motor development, and sport performance compared with the normal population . Thus, people with intellectual disab... |
Are pia - lined, interstitial fluid - filled structures that surround blood vessels as they enter the brain parenchyma . Although some authors consider vrs to be lymphatic spaces of the central nervous system with immunological properties, the clinical significance of vrs remains under investigation . We report a patie... |
Instrumentation of the root canal system is recognized as being one of the most important stages in root canal treatment . Endodontic treatment includes removal of vital and necrotic tissues from the root canal system, along with infected root dentine . Finally, the root canal must be cleaned, shaped and obturated accu... |
Due to the limited success of chemotherapeutic agents in the treatment of advanced cancer, novel anticancer drugs with different mechanisms of action need to be developed . One possibility is to target the deregulated iron metabolism of rapidly dividing cancer cells . The first candidate with potential anticancer activ... |
Genetic diversity within p. falciparum is a major characteristic and a factor by which the parasites survive the hosts' immune responses . (1987) established that genetic recombination occurs during meiosis, creating parasites of novel genotypes . Genetic diversity of malaria parasites represents a major issue in under... |
Intracranial and/or extracranial artery stenoses are characterized by narrowed arteries that supply blood to the brain, which can lead to cerebral hypoperfusion or impaired cognitive function, and promote the development of alzheimer s disease (ad). Ad is the most common type of dementia and represents a serious threat... |
This common electrolyte disorder is even more frequent in older patients and, indeed, increased age (> 60 years) represents a risk factor for the development of hyponatremia. Moreover, the most common symptoms associated with acute hyponatremia (developed in less than 48 h), such as nausea, vomiting, headache, and/or s... |
To report a case of retinal capillary hemangioma treated with verteporfin photodynamic therapy combined with intravitreal triamcinolone acetonide . A 15-year - old female presented with metamorphopsia in the left eye for 7 days . Examination showed peripheral endophytic retinal capillary hemangioma, macular edema, and ... |
We have previously shown that ubp6, the yeast ortholog of usp14, is a potent inhibitor of the proteasome16 . To test whether this is true of usp14 from humans, we first developed a purification procedure that results in proteasomes lacking detectable usp14 (modified from ref 23). Such proteasomes retain high levels of ... |
Burnout, attrition, and low work satisfaction of primary care physicians are growing concerns and can have a negative influencee on health care . We undertook this study as a first step in investigating whether an abbreviated mindfulness intervention could increase job satisfaction, quality of life, and compassion amon... |
Tragically, genital tract infections are still a major public health problem in many regions . Annually in the united states, more than 15 million new cases of sexually transmitted diseases (stds) were reported . Among females, some of them may lead to long - term pelvic inflammatory diseases, infertility, ectopic preg... |
Environmental factors acting early in life influence the risk of developing adult cardiovascular disease (cvd). Birth weight and/or infant weight and accelerated weight gain during childhood are associated with an increased risk of these disorders . Recent research has focused on the role of chronic, low - grade inflam... |
Mitochondrial neurogastrointestinal encephalopathy (mngie) is caused by mutations in the nuclear gene tymp . The tymp gene is located on chromosome 22q13.33, and it encodes thymidine phosphorylase, which catalyzes thymidine phosphorylation or the transition of deoxyuridine to thymine or uracil . Therefore, tymp dysfunc... |
Prostate cancer is the most common malignancy among men and the second leading cause of cancer death in the united states . Prostate cancer screening with prostate - specific antigen (psa) has led to earlier diagnosis with more lower - grade, organ - confined disease, leading to over - detection and over - treatment of... |
A number of cytotoxic pharmacological agents, such as nitrogen mustards and mitomycin c, produce dna interstrand cross - links (icls). Other exogenous and endogenous bis - electrophiles also produce icls by alkylating the nitrogenous dna bases in either the major or minor groove . Icls are absolute blocks to replicatio... |
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