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Although subantral augmentation procedures (sinus lifting) can be considered as an established and highly successful method to multiply bone prior to implant insertion into the lateral maxilla site, the biological mechanisms of subantral bone regeneration are still focus of controversial scientific discussions . While ... |
Mentoring or preceptoring in the first year of practice in nursing and midwifery has nearly always been thought of as a one - to - one relationship in which an experienced practitioner supports a novice . By contrast, this paper is derived from a naturalistic study of an innovative approach in which a group of experien... |
With the aging of the baby boom population and an increased life expectancy, individuals aged 65 years or older are the fastest growing segment of our population . Increases in the number of individuals aged 65 + years will increase demands on health care and health care costs, which could lead to inadequate public res... |
Patients admitted to the intensive care unit (icu) frequently present with acute respiratory failure and/or cardiovascular collapse, and endotracheal intubation is a frequently performed procedure in the critically ill . Not only do these patients present in extremis, but cardiopulmonary reserves are often limited comp... |
Visual and quantitative perfusion and function assessments of myocardial perfusion spect (mps) are important in detection and evaluation of coronary artery disease (cad).1 reproducibility analysis for these parameters is essential in understanding the significance of changes seen in serial studies . Most previous studi... |
Social engagement, the performance of meaningful social roles for either leisure or productive activity, has been shown to be associated with better cognitive function and lowered rates of cognitive decline and dementia in older adults [14]. Yet many questions remain regarding how social engagement can potentially get ... |
Sit - to - stand (sts) is a frequently performed movement in independent living . Dall and kerr (2010) reported that sts is the most frequent movement of sedentary workers1 . If the sts is disturbed by improper technique or factors restraining the human musculoskeletal system, repetitive movement of sts might contribut... |
It occurs in approximately 14 per 1,000 births and more often afflicts men than women . The defect may be accompanied by other developmental disorders of the genitourinary system and other organs . In the world literature, approximately 200 cases of tumours developing in the kidneys affected by this defect have been de... |
Patients with blunt traumatic thoracic aorta injuries are increasingly admitted to hospital due to the increasing number of traffic accidents per day . The thoracic aorta wall ruptures after blunt thorax trauma and if not treated, has very poor outcome with an initial survival rate ranging from 10 to 30% . The hospital... |
Clinical manifestations are typically mild and include erythema, nodules, and small ulcers . In certain cases, diagnosing lp may be challenging . Skin overlying the typical subcutaneous inflammation may appear normal, and bacterial superinfections of the skin sometimes mask the underlying lp . It has been suggested tha... |
Between march 2005 and december 2008, a total of 810 aneurysms were treated by either coil embolization or surgery at our institution . Of the 468 aneurysms treated by surgery, 142 (30%) were very small (3 mm) and of these, 40 (28%) were ruptured aneurysms . Whereas, of the 342 aneurysms treated by coil embolization, 3... |
It presents with a wide spectrum of clinical manifestations ranging from inapparent infection to fulminant and fatal disease . The clinical spectrum of the disease may be an influenza - like fever to a serious presentation like weil's syndrome, which is characterized by hepatic, renal, neurological, and hematological a... |
Class iii malocclusion is considered to be one of the most difficult and complex orthodontic problems to treat . Prevalence of class iii malocclusion in caucasians ranges from 0.8 to 4.0% and rises up to 1213% in chinese and japanese populations, while in north indian population, class iii malocclusion is found in up t... |
The elderly population has increased tremendously in the past few decades all over the world . The number of people aged 65 or older is projected to grow from an estimated 524 million in 2010 to nearly 1.5 billion in 2050, with most of the increase in developing countries . The 2011, united nations population division ... |
Re - establishment of proper esthetics and function in the anterior region is utmost important for the patient . Discolored, unsightly, malposed, malformed anterior teeth and midline diastemas can make the individual psychologically depressed and socially less active . The relentless pace of innovation and development ... |
Ventilator - associated pneumonia (vap) is a common complication in patients receiving mechanical ventilation in the burn intensive care unit (bicu). Vap results in substantial increase in morbidity and mortality [24]. Even though pneumonia is very common in the burn patient, the clinical and demographic factors that m... |
Pardo and patterson see neurolaw as it is currently practiced as founded on a thoroughgoing reductionism: the reduction of mind to brain and of mental processes to neural processes . In the place of this reductionist program, they want to assert the primacy of proper criteria for the ascription of mental properties to ... |
Soft tissue tumors of spermatic cord including spermatic cord liposarcomas are very rare tumors (1 - 2). Patients usually present with painless growing scrotal swellings . Most of them are clinically misdiagnosed as hernia (2 - 3). Based on the literature review, there are about 186 cases of reported liposarcomas in th... |
Tracheobronchomalacia (tbm) is characterized by decrease in strength of airway wall, which could be congenital or secondary . Secondary causes include chronic airway inflammation, gastroesophageal reflux disease, malignant or benign tumors around trachea and trauma to airways etc ., excessive dynamic airway collapse (e... |
Actinic keratoses (aks) are rough, scaly lesions that commonly occur on sun - exposed areas of the skin . Ak represents the most common carcinoma in situ of the skin, showinga continuously increasing incidence worldwide . Ak has been previously referred to as preneoplastic lesions, but is nowadays defined as intra - ep... |
Nasopharyngeal carcinoma (npc) is a rare head and neck cancer in most of the world, with an annual incidence rate of less than 1 per 100,000 . However, similar to southern china, north africa, and alaska, npc is endemic in taiwan with an annual incidence rate of 5.7 per 100,000 in 2007 . External beam radiotherapy (rt)... |
Early methods involved labeling proteins with reagents enriched in stable isotopes in order to introduce mass tags into proteins of interest for relative quantification of proteins [1, 2]. These reagents have been refined over the years and have found widespread use in the form of the itraq reagent . Metabolic labeling... |
While dermatologic practice occurs primarily in the outpatient setting, dermatologists also provide essential consultative services to the care of inpatients admitted to other medical disciplines . A dermatologic consult often leads to a revision to the original diagnosis made by the referring physician, ordering of sk... |
By 2020, the cost to treat diabetes mellitus, its complications, and its associated loss of productivity and life will exceed can$19 billion a year . Compelling evidence supports the benefits of intensive glycemic, lipid, and blood pressure control in the prevention and management of diabetes complications . However, d... |
The previous review in this series described how to use confidence intervals to draw inferences about a population from a representative sample . A common next step in data analysis this comparison may be a single observed value versus some hypothesized quantity (e.g. The number of babies born in a single delivery to m... |
Because of progress in technology in gastrointestinal (gi) endoscopy and improvements in the quality of stents, gi stenting as a palliative therapy for malignant gi obstruction has undergone a remarkable development . For acute obstructions caused by gi malignant disease, previously, rescue from the worsening condition... |
Hemiplegia associated with stroke, cerebral palsy, or polio commonly leads to movement disorders1 . The neurological dysfunctions of hemiplegic patients are often related to spasticity and/or contracture of ankle plantarflexors, low muscle activity of dorsiflexors, and loss of selectivity in motor control2 . Abnormalit... |
Electronic / artificial noses are being developed as systems for the automated detection and classification of odors, vapors, and gases . The two main components of an electronic nose are the sensing system and the automated pattern recognition system . The sensing system can be an array of several different sensing el... |
Studies have demonstrated that although the prevalence of chronic diseases in the elderly population of china is high, resulting in a heavy disease burden, the awareness, treatment and prevention of chronic diseases are generally poor in china . Although knowledge concerning the prevention of hypertension has been most... |
Stroke is a leading cause of movement disability in the us and europe.1 by 2030, it has been estimated that there could be as many as 70 million stroke survivors around the world.2 the proportion of patients achieving independence by 1 year after a stroke ranges from ~60% to 83% in self - care and between 10% and 15% i... |
The hoorn study is a population - based cohort study of type 2 diabetes and diabetes complications in the general population (9). A random sample of inhabitants listed in the municipal registry of hoorn was invited to participate in the study . The participation rate was 71%, and data on 2,484 dutch caucasian men and w... |
Alcohol plays a significant role in accidents, injuries, and their outcomes . According to the world health organization (who), there are 76.3 million people with alcohol use disorders worldwide; in 2000, 1.8 million deaths and loss of 58.3 million disability - adjusted life years were attributed to alcohol . Although ... |
Hydatid disease is endemic in mediterranean countries, south america, and the indian subcontinent . Involvement of kidneys is rare and forms 24% of cases. [25] renal hydatid cysts primarily develop when the larvae, which are not filtered in the liver, pass through the pulmonary circulation and travel to the kidney . Co... |
Head and neck squamous cell carcinoma (hnscc) is one of the most common cancers with more than 4,00,000 new cases and 2,00,000 deaths worldwide annually . Oral squamous cell carcinoma (oscc), as a subgroup of hnscc and the most common oral cancer, is estimated to be the eighth most common cancer in human population . D... |
Full - field electroretinograms (ergs) recorded with a contact lens electrode are generally used to evaluate retinal function . Among the six types of responses elicited by different stimulus intensities under different states of adaptation,1 the light - adapted 30 hz flicker ergs have been used to assess cone function... |
Renal stone disease is a common health problem that may lead to significant morbidity and mortality . Since its introduction, percutaneous nephrolithotomy (pcnl) has been accepted as the gold standard treatment modality for large and multiple renal calculi . Pcnl can achieve a high stone clearance rate but is also asso... |
Mary s hospital, college of medicine, the catholic university of korea (seoul, korea), between 2004 and 2012 . Histologic diagnosis of glioblastoma was performed according to the current world health organization (who) classification, fourth edition . All tumor tissues were obtained at the time of the first surgery aft... |
This study provides class iv evidence that dmf might preferentially reduce cd4 and cd8 memory t cells in ms . All patients were recruited at the department of neurology at the university hospital mnster, germany . Fifteen stable patients with rrms (ages 2454 years, mean age 40.7 years; 7 female, 8 male) were included a... |
The symptoms of cd are varied and atypical, with many patients having no gastrointestinal symptoms . Metabolic bone disease (mbd) is a less recognized manifestation of cd associated with spectrum of musculoskeletal signs and symptoms, viz . We here report five patients who presented with severe mbd as the only manifest... |
Jatropha curcas; known to be a gastrointestinal irritant and purgative has been used, both in ayurveda and the african system of medicine, for varied illnesses . Presently it is being cultivated on a large scale for use as biodiesel in india . Although an uncommonly reported source of poisoning; its cultivation for ext... |
Most of the patients hospitalized in the intensive care unit (icu) due to acute respiratory failure require endotracheal intubation and mechanical ventilation . In patients with an endotracheal tube, keeping the airway open cleaning methods and, thus, keeping the airway open include frequent change of patient position,... |
Natural physique competitions are based on subjective judgments of how a competitor appears on show day . In natural bodybuilding urinalysis and polygraph testing are done on or before competition day in an effort to uphold the competitor s natural status . For example, the north american natural bodybuilding federatio... |
At 35 weeks of gestation, a 37-year - old (height 162 cm and weight 85.1 kg) primigravida visited the emergency department with complaints of unceasing palpitations, without associated symptoms such as dizziness, syncope or dyspnea . Upon questioning, she described a history of occasional palpitations over the past few... |
Although preventable, tooth decay still remains a major dental health hazard in developing countries [1, 2]. Tooth caries is known as the most prevalent chronic disease of the childhood with a prevalence rate 5 times that of asthma and 7 times that of hay fever . This issue signifies the importance of modern concepts r... |
One of the most common and successful surgeries to treat end - stage knee disease is total knee replacement (tkr), which can relieve pain, improve function, and improve the quality of life . It is estimated that the demand for primary tkr will grow by 673% to 3.48 million procedures by 2030 in united states . But the s... |
The male - to - female ratio is 1:6 with a peak incidence between 50 and 60 years of age . The trans - abdominal procedure is generally considered more effective in healthy patients compared to perineal procedures [25]. Laparoscopic repair [69] seems as effective as open surgery with possible advantages such as faster ... |
Lymphoma of the cervix is a relatively rare tumor with an overall incidence of less than 1% among all cervical malignancies . The most common clinical presentation is abnormal uterine bleeding, although occasionally atypical lymphoid cells on a routine cervical smear have led to detection . While cervicovaginal cytolog... |
For motor recovery in patients with stroke, repetitive and intensive practice of voluntary motor control is essential . Utilizing this concept, diverse treatment methods, such as constraint - induced movement therapy1, electromyographic biofeedback2, virtual reality3, and task - oriented training4 have been attempted f... |
Hydrogen peroxide (h2o2) is an intracellular metabolite, which serves important roles as a second messenger in redox signaling . However, since elevated levels of h2o2 (and of other reactive oxygen species, ros) can damage proteins, nucleic acids, and lipids by peroxidation, temporal and spatial limitation of h2o2 leve... |
In an attempt to define the specific structural feature(s) of bryostatin that contribute to its activity or lack thereof, several representative compounds from the wender group s b - ring dioxane and b - ring pyran analogue classes were initially evaluated (see figure 2). Previous studies indicated that the c - ring fu... |
Dynamic nuclear cytoplasmic trafficking of macromolecules controls many eukaryotic cellular processes, such as gene expression, signal transduction, cell differentiation, and immune response . The karyopherin- family of transport factors recognizes targeting signals within cargo proteins for transport in and out of the... |
In recent years, with the increase in disasters, planning and hospital preparation considered an important part of policies and strategic objectives of health care in each country . Today, efforts to improve disaster management appear necessary . The study of natural disaster in the past and compliance them with possib... |
Fermented foods result from the metabolic activity of a complex and heterogeneous microflora, which multiplies using naturally occurring substrates within the food matrix while converting them to a broad range of molecules that confer unique composition and sensory features to the final products . The composition of su... |
Low - density lipoprotein cholesterol (ldlc) plays a prominent role in atherosclerotic cardiovascular disease (ascvd), which is a leading cause of death worldwide . When oxidized, small dense ldl particles are formed, which are engulfed by macrophages to form foam cells, the origin of an atheromatous plaque . At an ldl... |
Transient global amnesia (tga) is a syndrome which is recovered within 24 hours after anterograde and retrograde amnesia appear suddenly without other focal neurological symptoms or signs . Its pathological mechanism has not yet been proved enough but several factors, such as migraine, focal ischemia, venous flow abnor... |
Free radicals and other reactive oxygen species are involved in many disorders in humans, including cardiovascular disease, arthritis, diabetes, and cancer . Various studies reported that carbon tetrachloride (ccl4)-induced liver damage is related to high levels of free radicals that cause oxidative stress . In this st... |
The nhs was initiated in 1976, when 121,700 female registered nurses aged 3055 years completed a mailed questionnaire . Since 1976, information on disease status and lifestyle factors had been collected from this cohort every 2 years . Similarly, information about health and disease was assessed biennially with self - ... |
Integrins are plasma membrane proteins that generate complex and intracellular signals during morphogenesis, tissue remodeling, and repair . Interactions of integrins with specific extracellular matrix proteins and growth factors or with certain small molecules generate ligand - specific signals . The integrin superfam... |
According to media reports and assessments from local officials, there may be as many as 3,0008,000 cases of nodding syndrome in the districts of kitgum, pader, and lamwo in northern uganda, and western and central equatoria states in south sudan (1,15). In march 2012, the uganda government actively sought to register ... |
Serous tumours are the most common subtype, but these remain rare with fewer than 50 cases reported in the literature so far [1, 2, 3]. We report a case of a young man diagnosed with serous carcinoma of the testis, occurring 18 years after first diagnosis of a testicular germ cell tumour in the contralateral testis . T... |
Although regional anesthesia has been shown to be an effective means of providing postoperative analgesia, single shot techniques will provide only 812 hours of analgesia . As major orthopedic procedures may result in acute postoperative pain lasting 23 days, home catheter programs have been shown to be safe and effect... |
Primary biliary cirrhosis (pbc) is a chronic, progressive cholestatic liver disease that affects usually middle - aged women and occasionally leads to liver failure and liver transplantation [15]. Autoimmune pathogenesis is suggested in pbc [14], because pbc is serologically characterized by a high titer of serum antim... |
The seminal work using radiation - attenuated sporozoites has been reproduced in multiple experimental systems, demonstrating that attenuated infective forms of plasmodium sp . Administered by the endovenous route can provide solid vaccination status against any symptoms of malaria . However, the use of radiation - att... |
A fifty - one - year - old man was referred to our department because of a bulging contour in the right paratracheal area on chest x - ray, which was identified during a routine medical checkup (fig . He did not complain of any respiratory symptoms and denied fatigue, weight loss, weakness, or regurgitation after swall... |
Cardiovascular disease is responsible for a large and increasing proportion of death and disability worldwide . There is evidence that cardiovascular mortality decrease observed in industrialised countries in the second half of the 20th century has occurred concomitantly with an improved control of hypertension (13). H... |
A 22 year old female with new onset of generalized seizure activity of unknown cause underwent a head computed tomography (ct) examination that revealed focal hypo - density within the left frontal bone, consistent with fibrous dysplasia and extended back into the left parietal bone as well (figure 1). Despite anti - c... |
Patient's vision was 20/30 bilaterally with grade one relative afferent pupillary defect over the right eye . A mass was seen in the right retro - orbital space extending to the orbital apex [figs . Plain computerized tomography scan of right orbital axial view showed a homogenous enhancing retrobulbar mass involving e... |
Digital necrosis is a rare phenomenon of paraneoplastic syndrome associated with squamous cell carcinoma of the tonsil . Since 1965, more a 54-year - old male smoker presented with raynaud s phenomenon, proceeding to frank gangrene of the fingers . Working up the case finally pointed toward carcinoma of the tonsil as t... |
Restuans mosquitoes collected by mosquito surveillance programs in 2001 and 2002 in nassau (89 identified/100 tested), orange (66/87), rockland (83/96), and westchester (20/20) counties and in 2005 and 2006 in tompkins county (46/52) (1). Baited cdc light traps and gravid traps were used to capture host - seeking and o... |
Pentobarbital sodium (5-ethyl-5-(1-methylbutyl)-2,4,6(1h,3h,5h)-pyrimidinetrione, sodium) is a psychoactive drug with short - acting sedative effects in adult and paediatric patients . However, it is not any longer marketed in europe and in the united states . European drug agencies recently withdraw chloral hydrate, a... |
Spleens were harvested from b cell - specific traf3-deficient mice with b lymphomas or tumor - free littermate control mice (table 1). In the three selected traf3 splenic b lymphoma samples (mouse i d: 6983 - 2, 7041 - 10, and 7060 - 8), b lymphoma cells are> 70% of b cells as assessed by facs analysis of b cell popula... |
When considering long - term patient outcomes, direct clipping of the aneurysm neck is a still an effective and reliable technique, especially when treating a large, complex aneurysm . However, as surgical tools are now made primarily from a titanium alloy, there have been some reports of a scissor - like deformation w... |
Lateral dislocation of the patella is commonly encountered while intraarticular dislocations are rare and involve rotation of the patella around its horizontal or vertical axis.1 the vertical type occurs when the articular surface of the patella faces medially or laterally, indicating a rotation about a vertical axis, ... |
In 1963 rubinstein and taybi first delineated a syndrome characterized by broad thumbs, broad toes, mental and motor retardation, cardiovascular and renal anomalies, a beaked nose, and a downward slanting palpebral fissure1). Rubinstein - taybi syndrome (rts) includes a variety of cardiac problems such as an atrial sep... |
The incidence of cardiovascular disease among premenopausal is significantly less than that among age - matched men and postmenopausal women [mendelsohn and karas, 1999]. Estrogen replacement therapy for postmenopausal women significantly reduces the incidence of atherosclerotic diseases [mendelsohn and karas, 1999]. A... |
Pq poisoning has become a clinical challenge due to the lack of specific antidote or effective treatment . In recent decades a variety of parameters has been suggested to predict clinical outcome after ingestion of pq, including plasma and urine pq concentrations, urinary pq qualitative test, liver enzymes, serum creat... |
Tumor necrosis factor - a antagonists (anti - tnfa) are approved for the treatment of dermatologic, rheumatologic and gastroenterologic conditions . Although these drugs have been shown to have a good safety profile, numerous adverse effects have been described, including cutaneous side effects . We report a case of a ... |
Meralgia paraesthetica (mp) is a syndrome of burning neuritic pain along the distribution of the femoral lateral cutaneous nerve of the thigh (flcnt). Bernhardt roth syndrome, it was later called mp from the greek words meros (thigh) and algos (pain). The flcnt, derived from l2 and l3 roots, leaves the lateral border o... |
Giardia duodenalis (syn . G. intestinalis and g. lamblia) is a flagellate protozoan that is the cause of giardiasis . The protozoan infects humans and animals worldwide, and has been considered as a neglected disease by the world health organization since 2004 . Giardiasis is especially common in children in developing... |
Nsclc is the most commonly diagnosed subtype of lung cancer and one of the most aggressive human malignancies, with poor survival . Recent efforts in genetic studies have identified several reproducible genetic alterations underlying the pathogenesis of the disease, such as mutations in tp53, kras, and egfr genes, whic... |
Endophilin, a peripherally binding membrane protein, functions in multiple membrane trafficking processes that involve changes in membrane curvature . Endophilin consists of an n - terminal amphipathic helix (h0), a bin - amphiphysin - rvs (bar) domain, a src homology 3 (sh3) domain, and a flexible linker to connect ba... |
In march 2011, a large earthquake hit the coast of japan and triggered a powerful tsunami . Mass casualty incidents (mcis) caused by natural disasters such as earthquakes and floods have caught the world attention during the past few years . Disaster is defined as a serious disruption of the functioning of a society, c... |
The comprehensive study on domestic violence (dv) conducted by the world health organization (who) indicated that dv has probably always been part of the individual experience of women, and it results in physical, sexual, or mental injury or suffering (1). Domestic violence is observed in many countries and it can be a... |
Older rural adults comprise a large and increasing percentage of the population in the united states . As of 2014, more than 16% of the population aged 65 years and older the proportion of older adults in rural areas has grown rapidly due in part to aging in place, retirement transitions, and outmigration of younger fa... |
Tias admissions represent approximately 0.3% of ed (emergency department) visits, and about 23% of strokes are preceded by a history of tia . Recent studies have suggested that early care and rapid ed initiated treatment and diagnostic protocols within 24 hours can reduce post - tia stroke rates significantly [46]. The... |
A successful complete denture must provide esthetic, function, and health of supporting and surrounding tissues . Well - fitted dentures promote chewing efficiency, patient's comfort, and prevent the hyperplastic lesions . However, the dimensional changes of acrylic resins are inevitable, which is caused by processing ... |
Surgical treatment for primary malignant and aggressive benign tumors of the proximal femur involves wide excision of the proximal part . Reconstruction of these surgically created bone defects is challenging because improved survival of patients with musculoskeletal tumors is resulting in greater demands on the limb r... |
Aging and international migration are two prevailing global trends that have changed the age and ethnic composition of populations in countries worldwide, particularly canada, the united states, the united kingdom, and australia . The global share of older people (aged 60 years or over) increased from 9.2% in 1990 to 1... |
Granulocytic sarcoma is a localized tumor composed of immature cells of the granulocytic series, the majority of cases have been reported in association with acute myeloid leukemia (aml), mostly in childhood and frequently noted only at autopsy . First, they may occur in association with known acute myelogenous leukemi... |
The purpose of giving insulin in diabetes mellitus is to restore metabolism to normal, avoid symptoms due to hyperglycemia and glucosuria and to prevent short - term and long - term sequelae of diabetes . In order to reach these goals and to avoid potentially dangerous side - effects like hypoglycemia, it is vital to a... |
Triple - negative breast cancer (tnbc) is defined histologically as invasive carcinoma of the breast that lacks staining for estrogen receptor, progesterone receptor, and her2/neu . Tnbc is associated with high proliferative rates, early recurrence, and poor survival rates . This aggressive disease is insensitive to wi... |
Among protozoan parasites of the genus plasmodium, p. falciparum is the most deadly agent of human malaria, causing a broad spectrum of clinical manifestations ranging from asymptomatic to severe multiorgan disease . Despite recent major efforts by the research community, malaria remains one of the major diseases in po... |
Arterial supply to the left colon and rectosigmoid colon is from the inferior mesenteric artery (i m a) classically by means of left colic artery (lca), 2 - 3 sigmoid branches, and superior rectal artery . I m a originates from the front of the abdominal aorta, near its left margin just below the third part of the duod... |
The online version of this article (doi:10.1007/s40261 - 016 - 0376 - 0) contains supplementary material, which is available to authorized users . This analysis examined data from the early weeks (4, 8, and 12) of the dual i and ii studies in patients with type 2 diabetes, comparing the fixed - ratio combination produc... |
The application of genomic technologies to cancers has revealed that patients with tumors that appear indistinguishable to the clinician may have completely different causes at the molecular level [1, 2] resulting in very different prognoses and responses to possible treatments . Nonetheless, most human cancers seem to... |
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