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Griscelli syndrome type 2 (gs2) is a rare autosomal recessive disorder, characterised by partial albinism, immunodeficiency, organomegaly and accelerated phases1). During the accelerated phases, haemophagocytosis and pancytopenia occur which may be accompanied by neurological deterioration1,2,3,4). The elder boy had an... |
Health care associated infections (hcais) or hospital acquired infections (hais) are infections that occur during hospitalization but are neither present nor incubating upon hospital admission . Various factors like increasing incidence of hospitalization, rapid advancement in medical technology, and injudicious use of... |
Although atherosclerosis was long thought to be mainly a degenerative disease, it is now well ascertained that its pathogenesis is inflammatory . This antigen could be a fragment of oxidized low - density lipoproteins digested by macrophages, heat shock protein 60, 2-glycoprotein i, or fragments of bacterial antigens .... |
The presence of diverticula is called diverticulosis; when these diverticula become inflamed, the disease is termed diverticulitis . The diverticulum forms a pouch in a weakness of the intestine, which generally corresponds to the site at which an artery enters into the muscle layer . It is believed that spasms increas... |
Many studies have been done on the design and stress distribution of removable partial dentures rpds and abutment teeth using finite element method (fem), strain gauges, and photo elastic techniques [115]. Appropriate design in a rpd is critical for proper force distribution and avoidance of excessive loading of the pe... |
Pathogenic bacteria, which have to survive within an animal, are able to sequester iron from the iron - containing proteins of the host by secreting siderophores that have a higher affinity for the iron (reviewed in). Then, a specific transport system imports the iron - siderophore complex back into the bacterial cytop... |
Soon after hiv was discovered, the scientific community was optimistic that a vaccine against the aids - causing virus could be developed in a timely manner . More than 30 years of research have shown that a vaccine against hiv will be much more difficult to develop than the successful vaccines that exist for other pat... |
Biomoleculenanoparticle conjugates are increasingly important in a wide range of applications including bioanalysis, imaging, and medicine . In particular proteinnanoparticle bioconjugates have been used as electron - dense biospecific stains in electron microscopy for many years and more recently are showing promise f... |
Colorectal cancer is the third most common cancer in the uk and approximately 37500 new cases are diagnosed each year (1). Patients with colorectal cancer commonly present to the outpatient setting with changes in bowel habit, rectal bleeding or iron deficiency anaemia . Cases are also identified via the national bowel... |
Arecurrent miscarriage (rm) is defined as a condition of three or more consecutive pregnancy losses before 24 weeks of gestation (1). The causes of rm are parental chromosomal abnormalities, uterine anomalies, endocrine dysfunction, autoimmune disorders, maternal and paternal age, infectious diseases, environmental tox... |
Cholangiocarcinomas arise from the epithelial cells of the bile ducts in the intrahepatic, perihilar, or distal (extrahepatic) biliary tree, and are exclusive of the gallbladder and ampulla of vater . Intrahepatic cholangiocarcinomas originate peripherally within the intrahepatic ducts of the liver parenchyma, and form... |
Ribonucleotide reductases (rnrs) catalyze the formation of deoxynucleotides from their corresponding ribonucleotides (scheme 1) in almost all organisms; allosteric regulation of substrate specificity and activity contributes to fidelity of both dna replication and repair . The class ia rnrs contain two homodimeric subu... |
Recent studies have implicated glutamate (glu) signaling in the development and progression of malignant diseases . Glu, a non - essential amino acid, is the major excitatory neurotransmitter in the central and peripheral nervous systems (cns, pns). In addition, it functions as a source of energy for rapidly dividing c... |
The diagnosis and risk of death in patients with copd is usually estimated with the use of the forced expiratory volume in 1 second (fev1). However, physicians do not routinely recommend smokers to undergo spirometry,2,3 unless they are symptomatic, particularly with dyspnea . An important and unknown number of patient... |
Breast cancer is the most common cancer among women in both developed and developing countries . The incidence rate of this cancer is increasing, especially in developing countries (1, 2). For instance, the total cost of breast cancer was more than three times the total cost of prostate cancer, the most common cancer i... |
Skin disorder can be a potential source of emotional distress and psychiatric illness leading to impaired psychosocial adjustments . Emotional and psychosocial distress, in turn, may lead to psycho - somatic skin disorders . Dermatological diseases have a negative effect on the daily life, self - confidence, and self -... |
Phosphatase and tensin homolog deleted on chromosome ten (pten) is a tumour suppressor gene,1 which is deleted or mutated in approximately 45% of uterine endometrial cancers,2 30% of glioblastomas and spinal tumours,3 and less commonly in the cancers of the prostate,4 bladder,5 adrenal glands,6 thyroid, breast,7 skin (... |
Acute pancreatitis (ap) is a pathology with acute inflammatory manifestations, and constitutes around 3% of all inpatient cases of abdominal pain (1). All prevalence and incidence values of ap are based on hospital records and their accuracy is influenced by data collection methods, etiological and diagnostic approache... |
Expectations, with reference to healthcare, refer to the anticipation or the belief about what is to be encountered in a consultation or in the healthcare system . It is the mental picture that patients or the public will have of the process of interaction with the system . Patients come to a consultation with expectat... |
Periodontitis is a destructive inflammatory disease of the supporting tissues of the teeth and is caused either by group of / specific microorganisms, resulting in progressive destruction of the periodontal ligament and alveolar bone resulting in periodontal pocket formation and/or gingival recession . The potential of... |
Essentially, slrh is a form of dilution haplotyping similar to previous approaches based on fosmid clones or long fragment reads (lfr). It involves placing a small number of large ~710 kbp dna fragments into separate pools . Each pool has a unique barcode that identifies its fragments, which are then recovered from sho... |
Lumbar interbody fusion has become a widely accepted treatment for painful conditions of the lumbar spine from degenerative disc disease, instability, and stenosis . When outcomes are evaluated, higher fusion rates and improved pain reduction can be anticipated than from posterolateral fusion alone . The benefits of in... |
Hydatid disease, also known as echinococcosis, is a zoonotic disease caused by the larval stage of the echinococcus tapeworm . The two main types are echinococcus granulosus and echinococcus multilocularis belonging to the order cestoda and the family taenia . Humans may become intermediate hosts through contact with a... |
Competences over environmental matters are distributed across agencies ranging from the national to local level: there are fisheries to be preserved, migratory bird species to be monitored, habitats to be maintained, national parks to be managed, and each of those activities can be entrusted to national ministries or a... |
Kossard first described frontal fibrosing alopecia (ffa) as a scarring alopecia predominantly affecting postmenopausal women . Clinically, it presents as a symmetrical band of frontotemporal and/or frontoparietal hairline recession, slowly progressive in nature . While scalp alopecia predominates, concomitant loss of h... |
Oral submucous fibrosis (osmf) is a potentially malignant disorder that primarily affects any part of the oral cavity and sometimes even the pharynx . Osmf is found predominantly among the people of south asia and is closely linked with the habit of chewing betel quid and tobacco containing products . The tissues most ... |
Early detection, surgical technique refinements, and appropriate adjuvant therapy have improved the survival rates of primary gastric cancer patients . However, despite recent advances, gastric cancer is still the second most leading cause of cancer - related death in japan (2) and korea (1), and even after complete su... |
Total dislocation and extrusion of the talus is a rare injury produced by an excessive tibiotalar dorsiflexion or plantarflexion in combination with subtalar supination or pronation in high - energy traumas . Talar dislocation is a well - known lesion, but the majority of these cases consists of open fractures and disl... |
Approximately 10% of all clinically overt intracranial neoplasms arise from the pituitary gland and at autopsy, if histological examination of unselected autopsy material is to be believed, adenomas are present in as many as one in five cases (levy and lightman, 1993). Prolactin - secreting adenomas are the most common... |
Non - small - cell lung cancer (nsclc) includes the following major histological types: adenocarcinoma (ade) and squamous cell carcinoma (scc). Nsclc accounts for approximately 85% of all lung cancers, which makes nsclc the leading cause of cancer - related deaths worldwide.1,2 despite the advances in early detection, ... |
According to the world health organization (who) mental health is a state of well - being in which every individual is able to realize his / her own potential, can cope with the normal stresses of life, work productively and make a contribution to his / her family and community. Mental disorder is defined by psychiatri... |
Non - small cell lung cancer (nsclc) is the most common cause of cancer death in the world . Most patients with lung cancer are diagnosed as advanced stage and 5-year survival is about 10% in the setting metastatic disease . The most common sites of metastasis from lung cancer include the bones, liver, adrenal gland, a... |
Tension - free mesh repair currently represents the gold standard in inguinal hernia surgery . To date, meshes of many different shapes, varied chemical structure, and differing designs have been introduced into medical practice . Although the use of prosthetic materials reduced the rate of recurrence, it may be associ... |
Regenerative medicine concerns the repair or replacement of damaged, diseased or otherwise poorly functioning tissues and organs, with the aim of restoring biological functionality . Systems biology offers many opportunities at the research and clinical level for the experimentation and facilitation of regenerative med... |
Quality of life (qol) is a concept incorporating all the factors that might effect on an individual s life . In medical research it is more usual to consider health - related qol . The world health organization (who) defined health in 1948 as a state of complete physical, mental and social well - being and not merely t... |
Ovarian cancer is the fifth largest cause of death related to cancers and it is responsible for more than half of all deaths related to gynecological cancer . The diagnosis is usually carried out in its advanced stage and even though it responds well to primary treatment, achieving clinical remission in 50% of cases, a... |
Penetrating trauma of the skull base can occur by any number of mechanisms, but often involves the use of firearms . Fractures at the anterior base of the skull are common in these injuries,1 and often result in cerebrospinal fluid (csf) leaks . Csf leaks may be either spontaneous or traumatic, and most traumatic csf l... |
Posttraumatic stress (pts) and posttraumatic stress disorder (ptsd) after reproductive loss have not been well recognised, despite the growing documentation of adverse psychological states associated with reproductive losses . Our focus is on pts and ptsd but did not include acute stress disorder (asd) because asd is a... |
All procedures were approved by the university of texas institutional animal care and use committee and conformed to national institutes of health standards . Three adult male macaque monkeys (macaca mulatta) were trained to perform a visual fixation task in which gratings of different orientations were presented . Eac... |
Obstructive sleep apnea / hypopnea syndrome (osahs) is characterized by repetitive upper - airway collapse during sleep, causing sleep fragmentation, oxygen desaturation, and daytime sleepiness . Two factors that are generally accepted to have an effect on osahs are upper - airway muscular hypotonia (from neuromuscular... |
The human body is made up of 60 trillion cells that originate from a single fertilized egg . This suggests that the cells in the body go through roughly 46 rounds of cell division or mitosis . During mitosis, chromosomes, bundles of dna, form condensed structures to ensure the faithful transmission of the duplicated ge... |
In vivo bioluminescence imaging (bli) is a technology that is frequently used in the study of animal tumor models . It has been successfully used to follow many different types of tumors, such as prostate, breast, colon, ovarian, and lung cancers [28]. The in vivo bli method is based on the action of luciferase on luci... |
They include developmental and degenerative processes, as well as focal brain injury from stroke or trauma, and are subject to many genetic and environmental influences . The heterogeneity and complexity of individual clinical syndromes reflect interactions among patterns of neuropathology, individual differences in pr... |
Fibroosseous lesions of the jaws are characterized by replacement of medullary bone by fibrous stroma containing newly formed mineralized tissue like woven bone or cementum . Fibroosseous lesions comprise a diverse group of lesions like fibrous dysplasia, ossifying fibromas and osseous dysplasias . Fibrous dysplasia (f... |
Atherosclerosis is the principal cause of coronary artery and cerebrovascular disease, which together comprise the leading cause of death, accounting for a fifth of all deaths worldwide . Over the past decade, a major change has occurred in the understanding of the mechanisms responsible for the development and progres... |
Although intrahepatic arterioportal shunts rarely develop after radiofrequency ablation (rfa) (1), they may cause portal hypertension and variceal bleeding (2). We describe a case of a patient with rapid deterioration of esophageal varices caused by a large arterioportal shunt that developed after rfa of hepatocellular... |
In total 1,147 blood samples were collected from rodents: 1,060 were live - trapped, wild animals from <20 sites (table 1), and 87 blood samples were collected from a captive colony of wild house mice (9) and tested serologically . All animal research was conducted under license, according to uk regulations . Species k... |
The aim of the paper is to analyze the contribution of geographical indications (gis) to food safety . This is a first step, based on a theoretical analysis of possible connections between origin of products and food safety . In order to excavate possible links between gi and food safety, in the first part, the article... |
While noise can lead to serious hearing - related health problems, it can also cause general health problems such as attention impairment, anxiety, sleep disorder, and depression . However, the best known of these problems is noise - induced hearing loss which is commonly studied due to its irreversible character . App... |
The major risk factors for rising trends of non - communicable diseases (ncds) (heart disease, stroke, diabetes mellitus, cancer, and chronic respiratory diseases) in the asian regions, include tobacco and alcohol consumption, unhealthy diet, physical inactivity, and high blood pressure (bp). Hypertension is an establi... |
Schizophrenia is characterized by loss of brain volume that is at least in part progressive in nature, and which may represent an ongoing pathophysiological process (hulshoff pol et al ., 2008). This loss of brain volume may be explained by reduced neuropil rather than neuronal loss, suggesting abnormal synaptic plasti... |
Kasabach merritt syndrome (kms) is a potentially life - threatening coagulopathy characterized by enlarging hemangioma with severe thrombocytopenia . Kms is associated with kaposiform hemangioendothelioma (khe), tufted angiomas and rarely with congenital hemangiomas (chs). Almost 200 cases have been reported in the lit... |
Contrast agents play a critical role in cellular and molecular magnetic resonance imaging (mri), as they enable sensitive and clear visualization of cellular and physiological processes . The different contrast agents available for labeling cells share in common their ability to enhance signal contrast and have facilit... |
Since 1938, when the use of electro convulsive therapy (ect) was first described in the literature, it has played a major role in psychiatric medicine . Also, since its introduction in the 1950's, succinylcholine has remained the most common muscle relaxant used to modify the motor effects of ect . A coincidental assoc... |
Medullary thyroid carcinoma (mtc) is accounted for 3.510% of all thyroid malignancies [13]; the lesions are derived from the parafollicular c - cells which produce calcitonin . As for all thyroid nodules, the preoperative diagnosis is primarily based on ultrasonography (us) and fine needle aspiration cytology (fnac); h... |
We conducted this study at the teaching hospital of the chinese university of hong kong, prince of wales hospital, where a major outbreak of sars had occurred (9). Patients admitted with clinical features suggestive of sars were investigated for sars - cov infection by a combination of methods including direct detectio... |
Hemiplegic migraine (hm) is a rare type of migraine which involves reversible motor weakness and other aura symptoms . The disease is divided into familial and sporadic form by genetic studies or clinical history . Although gene mutation such as cacna1a, atp1a2 and scna1a were known to be related with familial hemipleg... |
Gastrointestinal stromal tumours (gists), first described by mazur and clark in 1983, are rare mesenchymal tumours of the alimentary tract . They are believed to result from activating mutations of proto - oncogenes c - kit or platelet - derived growth factor receptor alpha polypeptide . These mutations increase tyrosi... |
A 56-year - old man with a history of prior myocardial infarction and severe left ventricular dysfunction underwent an implantable cardioverter defibrillator (icd) implantation for primary prevention of sudden cardiac death . Since the patient had normal sinus rhythm and normal atrio - ventricular conduction, a single ... |
We prospectively studied children <16 years of age who came to the pediatric department at the vijayanagar institute of medical sciences, bellary, karnataka, southern india, with acute encephalitis syndrome during october 2005december 2007 . Children with acute fever and symptoms with an onset <14 days before coming to... |
Meckel's diverticulum (md) is remnant by incomplete obliteration of the vitelline or omphalomesenteric duct around the seventh or eighth week of gestation [1 - 3]. It is a true diverticulum that usually arises from the antimesenteric border of the distal part of ileum and contains all layers of the normal intestinal wa... |
The name is thought to come from the similarity between fruiting heads of this particular fungus and the brush or aspergillum, used for sprinkling of holy water . The spores of the aspergillus fungus are ubiquitous, usually introduced by inhalation and are frequent inhabitants of the human upper respiratory tract . Asp... |
According to programs of the world health organization (who), all nations around the world are committed to children s health in the form of health for all by the year 2000, and half of the nations are obliged to decrease under - five mortality rate to two - thirds of the current rate by 2015 (1,2). Considerations rela... |
Endovascular coil embolization is well recognized as the standard treatment for most cerebral aneurysms.4) it is considered safe and effective in preventing rebleeding after aneurysmal rupture.2) however, development of coil compaction on follow - up is reported in approximately 20% of cases, and half of them require r... |
Currently, conventional allergen immunotherapy (ait) with allergen extracts is not convenient for patients due to a multiyear treatment regimen . For some allergies, ait is only partially efficacious and can be hampered by unwanted side effects . To improve ait, novel vaccine candidates and accompanying adjuvants that ... |
The world health organization estimates that more than 180 million people worldwide have diabetes, and by 2030 it is expected that this number will have doubled . There is an alarming increase in the incidence and prevalence of diabetes mellitus (dm) in asian indians . The alveolar capillary network in the lung is a la... |
Survival in a terrestrial environment necessitates the prevention of water and electrolyte loss through the body surface to minimize desiccation . In mammals, the epidermal permeability barrier in the cornified layer of the skin (stratum corneum) provides this function . The barrier is built during keratinization and c... |
Life - threatening bleeding in over - anticoagulation or proper - anticoagulation with warfarin is an emergency challenging issue . Several patients require chronic administration of anticoagulant therapy rendering them more prone to spontaneous and trauma - induced bleeding . Strategies for treatment or prophylaxis of... |
Etizolam is a thienodiazepine anxiolytic and is said to have low tolerance and dependence liability than benzodiazepines . We report a case of etizolam dependence in a young male with social anxiety disorder to highlight the abuse and dependence potential of etizolam . We present a case of 23-year - old male who presen... |
Apoptosis is the process of programmed cell death that serves critical functions for the development and homeostasis of multicellular organisms . Loss of apoptotic control could lead to tumorigenesis, and resistance to apoptosis is considered as a hallmark of cancer . Therefore, a myriad of efforts have been taken to t... |
Many methods for preparation of these heterocyclic ring systems and their fused analogues have been described in the literature . 2-amino-1,3,4-thiadiazoles as amidine moiety provided a useful method for the synthesis of thiadiazolopyrimidine . Also, the n - alkylation could occur either on the endocyclic or on the exo... |
Atrial fibrillation (af) is the leading cause of stroke.1) however, a few studies suggest that some of af may be a result from stroke . Previous studies reported paroxysmal or asymptomatic af after acute ischemic stroke had already occurred, in patients without previous history of af . Incidental impairment of autonomi... |
In mid - february 2009, a 22-year - old man with a remote history of lyme disease (ld) was transferred to columbia university new york presbyterian hospital (cunyph) after an extensive work - up for aseptic meningitis . On december 20, 2008, he had flown home to eastern long island, new york, from colorado . Sore throa... |
Schizophrenia is a complex neurodevelopmental disorder (weinberger 1987; lewis and levitt 2002), in which susceptibility genes are assumed to play a specific role in the pathophysiology of the disease via abnormal synaptic connectivity (harrison 1999). Genome wide scanning and mapping of regions associated with risk fo... |
Since dr . John l. h. down first described the patients with mental retardation and characteristic facial appearance, down syndrome (ds) has been characterized as one of the most common genetic disorders with an incidence of 1 in every 700~800 live births . Ds patients also display cognitive impairment, learning and me... |
Bone graft is a tissue or material used to repair a defect or deficiency in contour and volume . Bone grafts sources consist of autogenous bone grafting, alloplast substances, xenogenic bone substance, and tissue engineered osteogenic material like osteoinductive agents . The most popular sources of graft in maxillofac... |
We discuss the differential diagnosis of these lesions and the surgical approaches to reach this complex anatomical region . A 43-year - old man came to our clinic with a history of significant chronic neck pain . He was referred to us due to a lesion in the axis seen on magnetic resonance imaging (mri). The mri showed... |
Complete radial tears of the prmm are often associated with degenerative changes in knee joint . The meniscus has a good blood supply at its posterior tibial attachment site (which contains the perimeniscal capillary plexus and small vessels that penetrate the meniscus); hence, the meniscus has good repair potential.4)... |
Among the different classes of immunoglobulins (iga, igd, ige, igg and igm), igg is the most commonly used and hence, will be the focus of this review . In general, antibodies consist of two distinct functional units: the fab and the fc regions (figure 1). The fab portion of the antibody contains the variable region co... |
Caries is today, regardless of the good knowledge about its multiclausal etiology and the possibilities for its effective prevention still the most widespread disease of our civilization, which affects about 95% of our population (1). It affects all populations and age groups (2), this is a disease that is very difficu... |
All subjects were part of our ongoing longitudinal study of the etiology of type 2 diabetes among the gila river indian community in arizona (1). Association with type 2 diabetes was initially assessed in a population - based sample of 3,501 full - heritage pima indians . Among these individuals, 1,561 had been diagnos... |
The online version of this article (doi:10.1007/s40291 - 013 - 0059-y) contains supplementary material, which is available to authorized users . Ovarian cancer has the highest mortality among gynecological malignancies in europe and the usa [1, 2]. Several factors, including genetic background, are known to increase th... |
W opisywanym badaniu zwizek pomidzy jednonukleotydowymi polimorfizmami genu sirt1: rs7895833, rs7069102 oraz rs2273773, zosta zbadany poprzez analiz rnych danych laboratoryjnych . Do badania wczono dane 100 pacjentw z pochp z archiwum oddziau chorb klatki piersiowej wydziau medycyny uniwersytetu mula sitki kocman . Gen... |
Sugar - free chewing gums have been suggested to decrease the caries incidence as they have an anti - cariogenic effect . This effect is based on the action of two factors: saliva stimulation through the chewing process and integration of dietary polyols . In recent years, the use of chewing gum after meals has gained ... |
Chronic hepatitis b virus (hbv) infection is a major public health problem and leading cause of chronic liver disease and hepatocellular carcinoma (hcc) in korea . In the past 10 yr, remarkable strides have been made in the antiviral therapy of hbv infection . However, due to many limitations in the current treatments,... |
Fifty percent of the world population, approximately three billion people, use solid fuels (charcoal or biomass materials) as their main or alternative household energy source.1 in developing countries, especially in the rural areas, the use of wood, dung, and crop residues are common resources for cooking and heating,... |
Optical control of biological processes conveys unprecedented spatial and temporal control over the activation and deactivation of cellular events, enabling complex investigations that cannot be conducted with other conditional control elements . Examples of cellular processes that have been engineered to respond to li... |
Squamous cell carcinoma (scc) in the oral cavity is a common disease that is associated with several risk factors, including smoking, alcohol use, viral infection, immunosuppression, malnutrition, chronic irritation as well as previous disease such as odontogenic cyst . Scc associated with odontogenic cysts are extreme... |
New molecular targeted drugs have rarely been used in cor pulmonale and there is no large randomized study evaluating the efficacy of inhaled iloprost in cor pulmonale and pulmonary hypertension associated with chronic obstructive pulmonary disease (copd). A 51-year - old female patient with tuberculous destroyed lung ... |
In developed countries, people aging 65 and older constitute approximately 20% of the population and are the fastest - growing segment of the population . With this growing aging population, being relocated to an assisted living facility can result in functional and health disturbances and worsen quality of life in eld... |
Dengue virus (denv) has four serotypes, named as denv-1, denv-2, denv-3 and denv-4 . The majority of dengue infections are subclinical; however, the clinical manifestations of dengue infection range from the benign, self - limited dengue fever (df) to a vasculopathy syndrome known as dengue hemorrhagic fever (dhf) that... |
Study on ict - based solutions for caregivers: assessing their impact on the sustainability of long - term care in an ageing europe (carict), which ran throughout 2011 . Carict was aimed to find out the extent to which information and communication technologies (ict)-based services for informal carers and their paid as... |
We used data on absenteeism caused by influenza from the 54 elementary schools in joetsu city, niigata prefecture, japan during the 4 influenza seasons during 20052008 . Data was obtained between the second week of january to the third week of march for each influenza season . Current public health policy prevents infl... |
Mesenchymal stromal cells (mscs) are also known as stromal stem cells, mesenchymal stem cells, and adherent non - hematopoietic stem cells . These cells derive from one of the germ layers, and have the potential to differentiate into tissues originating from the mesoderm, although some sources report that their plastic... |
Disaster in a hospital set up is declared when the requirements overwhelm the resources of the involved hospital . Hospital disaster may be of any size and is not limited to mass casualty incidents (mcis). India with its mammoth population, diverse culture, mass gatherings and densely populated regions make the problem... |
The nuclear factor kappa b (nf-b) family consists of transcription factors activated in response to a variety of cellular stressors . The transcription factor nf-b is a key component of the cellular response to damage, stress, and inflammation [2, 3]. The nf-b proteins consist of 5 subunits, which bind to dna as a dime... |
In 1994, brazil introduced the publicly funded and provided fhs as the operating model for delivering primary care, free at point of use, as part of a wider health and social care reform based on the new constitution of 1988 . The fhs serves as a primary care provider and gatekeeper to brazil's national health service ... |
The neurogliaform family of cells is one of the major groups of gabaergic neurons expressing nitric oxide synthase (nnos). Neurogliaform cells, originally described by cajal as arachniform cells (ramn y cajal, 1922; ramn y cajal, 1999), together with the closely related ivy cells, which were only recently characterized... |
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