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Optimal tunnel placement and graft alignment are important factors associated with successful outcomes of anterior cruciate ligament (acl) reconstruction1,2). However, one of the major limitations of the transtibial technique for acl reconstruction is that the femoral tunnel cannot be placed properly inside the interco...
Conducting polymers (cps) have gained popularity in recent years as components of complex systems designed to electrically communicate with biological environments . Indeed, cps provide new ways to communicate with cells, tissues, and other multicellular structures as they can avoid the mechanical mismatch of harder in...
Eosinophilic hyperplastic lymphogranuloma, it gained prominence as kimura's disease following a report by kimura and coworkers in 1948, which elaborated on an unusual granulation combined with hyperplastic changes in lymphoid tissue. Kimura's disease primarily involves the head and neck region, presenting as deep, subc...
With a mortality up to 250 times greater than strains that cause epidemics the lethality of the 1918 avian h1n1 influenza pandemic is frequently reported (palese et al, 2006; taubenberger and morens, 2006), but seldom appreciated is the fact that the majority (> 97%) of those infected survived, amounting to 0.8 - 2 bil...
Nowadays ureteroscopy has become the treatment of choice for managing ureteral stones, specially mid and distal ones . There is no consensus on placing a ureteral catheter after uncomplicated ureteroscopy and it is still controversial . It is a routine justified by the belief that this practice decreases ureteral stric...
A 35-year - old man had presented with a periumbilical mass 10 days earlier . On physical examination, computed tomography (ct) revealed a well - circumscribed, multilocular cystic mass along the midline of the lower abdomen, measuring 9 cm in its maximum diameter . Punctate, annular, curvilinear and peripheral calcifi...
When first described by gaglio in 1886, measurement of lactate levels required the collection of 100200 ml blood and took several days to complete . The labour - intensive nature of early lactate measurement techniques limited their clinical use, because results were not available until long after therapeutic decisions...
Pars plana vitrectomy (ppv) is the most common surgery performed by vitreoretinal surgeons . This procedure is used to treat for an increasing number of indications and is done on eyes with relatively good vision . During their fellowships, vitreoretinal (vr) surgery fellows are required to perform a considerable numbe...
In the past, peritoneal carcinomatosis (pc) from gastric cancer has been regarded as a terminal stage, and the most oncologists regarded as a condition only to be palliated . Preusser et al . Published a response rate to chemotherapy of 50% of patients with stage iv gastric cancer, but the response rate was the lowest ...
Though there is no generally accepted definition, stress is usually defined as a state of disturbed homeostasis evoking a multiplicity of somatic and mental adaptive reactions, which are summarized as stress response aiming to reconstitute the initial homeostasis or allostasis, ie, a new level of homeostasis after succ...
Retinopathy of prematurity (rop), which is a major cause of visual impairment in children, is a vasoproliferative disorder associated with premature birth . Laser photocoagulation is the gold standard treatment for proliferative rop and has proven useful in reducing progression of classic rop [2, 3]. However, in treati...
Any such use of drug products is submitted to rigorous scrutiny before marketing approval inform of in vitro studies, animal studies, clinical trials . These data provide specific labeling information, that is, approved indications for use, the appropriate dose and the specific populations for its use . The exorbitant ...
Variability of the complex systems enable those systems to respond to different environmental and intrinsic inputs in a whole spectrum of reactions and effects . Heart rate variability reflects the possibility of the cardiovascular system to adapt to the whole spectrum of different more or less demanding tasks and situ...
Blepharochalasis is a rare degenerative disease unique to the skin of the lids, clinically characterized by primary bilateral swelling followed by progressive loss of subcutaneous tissue resulting in fine wrinkling and the skin of the upper lid hangs in thin folds . A 24-year - old female presented with history of inte...
Norman j. holter (19141983), the famous american biophysicist, introduced a remote cardiac telemetry first time in the 1940s . The holter system was developed for home ecg monitoring of patients with suspected cardiac arrhythmias . The original holter monitor had analog patient interface electronics, a 75 lb backpack w...
Approximately 1% of all pacemakers are implanted in infants and children.1 the majority of these are required for complete heart block related to surgery for congenital heart disease or congenitally acquired problems.2,3 although there has been recent progress suggesting that the transvenous route may be feasible, due ...
The great (long) saphenous vein (gsv) is a superficial vein representing preaxial vein of the lower limb . It begins in the medial marginal vein of the foot and ends in the femoral vein below the inguinal ligament . During its course, it ascends in front of the tibial malleolus and obliquely crosses the lower part of t...
For instance, hno has been implicated in the mechanism of the inhibitory effect of cyanamide on aldehyde dehydrogenase in treating alcohol abuse(4) and has been demonstrated to enhance contractility in experimental models of heart failure. (9) that hno rapidly and irreversibly dimerizes and dehydrates to produce nitrou...
There is a specific hierarchy of laboratory services in minisrry of health (moh), iran .although there are 31 provinces in iran, moh has divided the country to 49 regions each of which is under supervision of its dedicated medical university . There is an office of laboratory affairs in each university that is responsi...
There is an important interplay between choice of oviposition sites where eggs are protected against predators, where environmental conditions are suitable for egg development, and larvae can use the chosen substrate as life habitat (van loon, 1996). For the dipteran liriomyzea sativae (agromyzidae) a genetic covarianc...
Assessment of fetal weight is a vital and universal part of antenatal care, not only in the management of labor and delivery but often during the management of high risk pregnancies and growth monitoring . Birth weight of an infant is the single most important determinant of newborn survival [1, 2]. Both low and excess...
Epstein - barr virus - related post - transplant lymphoproliferative disorder (ebv - ptld) is a serious complication after stem cell transplantation (sct), associated with as high as 90% rate of mortality only a decade ago . The varying incidence ranging from 0.45% to 29% of reported ebv - ptld in sct recipients is rel...
Avaliar os efeitos de um programa educativo ambulatorial em pacientes com asma no controlada . Estudo no controlado, avaliando uma interveno educacional e envolvendo pacientes com idade 14 anos com asma no controlada . Os participantes responderam a um questionrio para avaliar o grau de controle da asma, a qualidade de...
It is characterized by painless dilation of the cervix, usually followed by bulging and premature rupture of membranes, which leads to miscarriage or preterm birth . The diagnosis is challenging because of the absence of clear diagnostic criteria, and it is generally made retrospectively, based on obstetric history . T...
Lung cancer still remains the main cause of cancer death among males after prostate cancer and the second main cancer among females after breast cancer 1 . Lung cancer can be distinguished between non - small cell lung cancer (nsclc) and small cell lung cancer (sclc). Early detection still remains a major issue since s...
In periodontal surgery, the surgical site is usually covered with surgical dressing . The history of dressing dates back to 1923 when ward introduced wondrpack with the aim of protecting the surgical site, splinting of soft tissue and mobile teeth, immobilization of the surgical site, preventing tooth hypersensitivity ...
In recent years isoflavones (a group of phytoestrogens) have generated much attention both in science and in public due to their potential health beneficial effects in relation to diseases such as atherosclerosis, breast, endometrial, and prostate cancer, but also osteoporosis reviewed by duncan et al . Especially legu...
First described by jacqueline noonan in 1962, noonan syndrome (ns) is a congenital genetic disorder with an estimated prevalence of 1 in 1000 to 1 in 2500 live births . We report a case of chronic tubulointerstitial nephritis in a child with ns and a solitary kidney . We present a case of a 7-year - old male child who ...
Cystic fibrosis (cf) is the most common lethal autosomal recessive disease in the caucasian population and is caused by mutations in the cystic fibrosis transmembrane conductance regulator (cftr) gene . Cftr is a pka - regulated chloride channel localized at the apical surface of primary epithelia such as those found i...
Abbot ice shelf is underlain by e - w rift basins created at 90 ma amundsen shelf shaped by subsidence, sedimentation, and passage of the ice sheet bellingshausen plate boundary is located near the base of continental slope and rise abbot ice shelf is underlain by e - w rift basins created at 90 ma amundsen shelf shape...
Large, randomized trials of multivessel balloon angioplasty versus coronary artery bypass grafting (cabg) in aggregate show no difference in long - term mortality in patients randomized to either approach initially . There is, however, an increased need for subsequent percutaneous or surgical target vessel revasculariz...
Perceptual rivalry amuses and intrigues those who experience it and those who study it . Though it has many faces, the phenomenon is defined fundamentally by conflicting or ambiguous sensory input that induces involuntary alternations in perception . Famous examples include ambiguous figure rivalry (afr) such as the ne...
This technique is also faster than the temporary rim removal approach, but it still has the disadvantages of limited visibility of the deep lateral wall while working through a relatively tight keyhole . The deep lateral decompression technique is mainly directed to bone removal from the greater wing of the sphenoid, w...
Central nervous system (cns) inflammatory demyelinating disease (idd) is characterized by inflammatory lesions associated with loss of myelin and eventually leading to axonal damage . Idd includes a variety of clinical syndromes, the most common include multiple sclerosis (ms), neuromyelitis optica and acute disseminat...
The term neonatal death dwarfism indicates bone dysplasias . Such bone - related entities always have a fatal outcome . Skeletal dysplasias are genetically determined constitutional disorders of bone growth and development that result in radiographically demonstrable abnormalities of size, shape, density, or behavior o...
Marital satisfaction is a major determinant in overall happiness of the individual and an unhappy marriage could profoundly affect one s physical and mental well - being (14). For this reason, years of research have been dedicated to understanding marital satisfaction and its contributing factors . In particular, numer...
Long - term synaptic plasticity is thought to represent the cellular basis of learning and memory in brain circuits . Since its discovery in the early 1970s, various mechanisms and sites of expression have been described in detail . However, the spatiotemporal distribution of synaptic plasticity has been poorly investi...
Splitting water into the fuel h2 and byproduct o2 using sunlight represents a sustainable strategy to produce renewable and storable energy . The design of solar water splitting systems remains an enormous challenge, and no commercial application of such technology exists despite extensive efforts over several decades ...
Between 2000 and 2007, 141 patients underwent endovascular aneurysm repair at our institution, and 33 endoleaks (23%) occurred . Based on follow - up imaging, the endoleaks were categorized as type i in 12 patients (9%), type ii in 16 patients (11%), type iii in two patients (1%), type iv in one patient (1%), and type ...
There are limited data on the prevalence of newly diagnosed thyroid disease during pregnancy from india . Therefore, this study was designed to evaluate the prevalence of thyroid dysfunction, especially hypothyroidism during the first trimester of pregnancy . The present cross - sectional study was conducted at departm...
Temporomandibular joint (tmj) ankylosis is a prevalent cause of mandibular deformity and distortion in children due to trauma or infection . The major goals towards the treatment of tmj ankylosis are to establish movement and functioning of the jaws, avoid relapse or setback and achieve normal growth, occlusion and def...
Protein domains were initially described as stable or autonomously folding units of protein structure, inspired by first results from the experimental characterization of protein three - dimensional (3d) structure . This definition of protein domains tends to coincide remarkably often with what has emerged from systema...
Few drugs have revolutionised the care of metastatic cancer patients as much as the bisphosphonates . These inhibitors of osteoclast function have undergone extensive clinical development over the last 20 years and have been shown to reduce hypercalcemia, bone pain, fractures, radiotherapy use, spinal cord compression ...
Heart valves are critical structures in the function of the heart, and the surgical repair of diseased valves has become a major form of treatment for patients with valve disease . Paradoxically, little is known about the structural components that are critical factors in the function of the heart valves . However, the...
Dental caries is among the most prevalent and costly oral infectious diseases worldwide (1). The etiology of dental caries is associated with bacterial metabolism of carbohydrates leading to plaque acidication and demineralization of dental hard tissues . Classic bacterial virulence factors contributing to the initiati...
Gossypiboma is the term used to refer to an intraoperative mistake discovered postoperatively in which one or more surgical sponges, gauze pads, or other form of textile is left behind in the operative field after the patient is closed . Retained surgical sponges may become a nidus for infection and are often grounds f...
This cross - sectional study was conducted in the hiv clinic of imam khomeini hospital complex in tehran, iran during a one year period . Fifty nine (42 males and 17 females), 18 to 55 year old hiv positive patients were included in this survey . The stages of hiv infection were determined according to 1993 revised cla...
Maternal uniparental disomy of chromosome 14 (upd(14)mat) is a rare chromosomal disease in which both chromosomes 14 are inherited from the mother, instead of one copy from each parent . Willi syndrome (pws), are prenatal and postnatal growth retardation, hypotonia, feeding difficulties in the neonatal period with a ca...
The number of patients with the human immunodeficiency virus (hiv) has been steadily increasing in korea since the first reported case in 1985 (1, 2). According to the annual report from the korea centers for disease control and prevention (kcdc), a total of 6,120 hiv patients, of whom 5,036 patients were living, were ...
Free - living amoeba (fla) including acanthamoeba, vermamoeba and vahlkampfia are the opportunistic protist ubiquitous in the nature and they can cause severe threatening keratitis in high - risk people . Poor hygiene in maintenance of contact lens especially soft contact lens and cornea trauma are the major risk facto...
American association of endodontists defined and characterized root canal obturation as a three - dimensional filling of the entire root canal system as close to the cemento - dentinal junction as possible . So far as gutta - percha is the most popular and commonly used root canal filling material . It has been taken a...
According to the fifth edition of the diagnostic and statistical manual of mental disorders (dsm-5), rapid cycling bipolar disorder is defined as the presence of at least four mood episodes within a 12-month period that meet the criteria for hypomania, mania, or a major depressive episode.1 significantly, the prevalenc...
A decision analytic model (figure 1) was developed to compare the lifetime costs and effects of genetically screening all uk aj women age 30 years and older for brca fm, compared with the current practice of screening using fh - based criteria (10% mutation risk) (supplementary table 1, available online). The model ass...
We performed a case - control study during (sept 2009 march 2010) to estimate the frequency of bkv and jcv virus in renal transplant recipients . We enrolled 30 first kidney transplant patients as case group who were hospitalized for renal allograft failure, aged 18 years or older at 1 to 24 months post - transplant ti...
The incidence of breast cancer in women is about 15% in the uk . In the united states about 230,480 new cases of invasive breast cancer was diagnosed in women . Based on the latest statistics, the statistics of cancer incidence is increasing in iran . A variety of screening tests are used to detect breast cancer e.g., ...
Introduction of the yeast knockout collections, containing arrayed strains harboring deletion mutations for> 95% of predicted open reading frames (orf), allows systematic genome - wide screens for various phenotypes to be readily accomplished (13). One aspect of the knockout collections that facilitates rapid screens i...
Acute kidney injury (aki) is a common problem in critically ill patients and is independently associated with increased morbidity and mortality . Observational data indicates that the incidence of aki is rising and associated with high mortality despite several advances in its management . In a large heterogeneous coho...
It is also called peritonitis fibrosa incapsulata or abdominal cocoon and was originally described in 1907 as a membranous encapsulation of the small intestine . It was then further investigated and a detailed description was made by foo et al . In 1978 . According to the literature, this disease presents most commonly...
Adhesive interactions between cells and their environment (other cells and the extracellular matrix) are key regulators of tissue organization . In the past several years, we have come to appreciate that these interactions are intrinsically dynamic, and it has been attractive to postulate that adhesion dynamics may con...
Urinary stones are one of the most common urological problems worldwide and are actually an ancient source of serious morbidity . Urinary stone prevalence is about 1%-5% in asia, 5%-9% in europe, and 13% in the united states . An average of 12% of people across populations has a history of urinary stones, and the overa...
Over a three - year span, the centers for disease control and prevention (cdc) recorded that african americans and hispanics, respectively, had a 51% and a 21% greater prevalence of obesity than caucasians . Statistics show that the risk of developing diabetes among african americans and latinos is twice that of caucas...
Smell is an important human sense odors can influence our mood, cognition, and behavior (for a review, see: herz 2002). The functions of our smell may be categorized into three main groups (stevenson 2010): related to ingestive behavior (murphy 1985; porter et al . 2006), alarm functions avoiding environmental hazards ...
Major histocompatibility class ii (mhc ii) pathway plays an important role in immune function . The molecules of mhc ii are expressed on the surface of antigen - presenting cells such as macrophages, b cells, and dendritic cells . Once the processed antigen loaded onto mhc ii molecules is presented on the surface of th...
Glucagonlike peptide1 (glp1) and glucosedependent insulinotropic peptide (gip) are incretin hormones that are secreted from the gut in response to ingestion of nutrients and stimulate insulin secretion from pancreatic cells . On secretion, glp1 and gip undergo rapid processing catalyzed by dipeptidyl peptidase4 (dpp4) ...
The utility of stem cells to regenerate whole tissues is a cherished goal in tissue engineering . As embryonic stem cells (escs) are capable of differentiating into osteoblasts (bone forming cells) and are relatively immune - privileged . However, the clinical utility of escs is currently still limited because of 1) th...
This meta - analysis was conducted according to internationally accepted reporting guidelines (22). Studies were identified by searching the national center for biotechnology s pubmed / medline database, embase (elsevier), the web of science (thomson), biosis (thomson), cinahl (ebsco), cochrane central (wiley), and the...
We recently showed that p - selectin, a biomarker greatly associated with coronary disease and inflammation, increased after a marathon . Serious cardiac events have also rarely been associated with marathon running, and increases in such biomarkers of thrombotic and vascular risk such as p - selectin may contribute to...
Improvements in the techniques of adhesive dentistry have allowed the use of minimal invasive cavities and aesthetic fillings . During the past few years, adhesive bonding systems have submitted major developments and the durability of adhesive restorations has continually grown . Resin - composites and glass ionomer c...
Anterior inferior cerebellar artery (aica) aneurysms account for less than 1.0% of all intracranial aneurysms, and distal aica aneurysms are even more rare and constitute only about 0.1% . Most aica aneurysms are found after rupture, and in such situations, it is not always easy to detect the presence of thrombus in th...
Chemotherapy drugs are known to cause damage to the veins through which they are administered . Wider bore veins, especially the central veins, can receive chemotherapy better as the drug becomes diluted before coming in contact with the vascular endothelium . For this purpose, various devices such as peripherally inse...
Green fluorescent protein elongated hypocotyl 5 far - red light absorbing form of phytochrome red light absorbing form of phytochrome it was also supported in part by the leaping research (nrf-2015r1a2a1a05001636) and global research lab (nrf-2012k1a1a2055546) programs provided by the national research foundation of ko...
The adipose tissue is a complex and metabolically active tissue which secretes a variety of adipokines (e.g., adiponectin, tnf-, il-6, and il-10) that play pivotal roles in metabolic regulation . Thus, it has been suggested that the abrupt decrease in adipose tissue brought about by liposuction could affect adipokine s...
The integument is composed of the epidermis and the dermis, which derive from different embryological sheets . The epidermis is the surface epithelium that originates in the ectoderm, meaning it is part of the structures that are in contact with the outside world.1,2 among the other structures derived from the ectoderm...
Although gynaecological surgery, especially hysterectomy, accounts for most ureterovaginal fistulas in developed countries, the scenario is completely different in developing countries where obstetric services are still below standard [1, 2, 3, 4, 5, 6]. Reports from nigeria indicate that caesarean sections and caesare...
Dizziness is one of the most common complaints in medicine and encompasses various abnormal sensations relating to perceptions of the body s relationship to space . Typically, dizziness is divided into four subtypes: vertigo, lightheadedness, disequilibrium and oscillopsia, and this classification is still the basic de...
It can be argued that the first official public health dietary guidance originated with the british merchant seaman s act in 1835, which suggested lime or lemon juice for sailors to prevent what we now know as scurvy . Since then, guidelines for healthy food patterns have been refined and are still important nutrition ...
A small heterocyclic ring containing nitrogen and sulphur has been under investigation for pretty long time owing to their potential biological features . Among these heterocyclics, thiazolidinones having thiazol nucleus have been reported to display wide spectrum ofimportant biological activities leading to their medi...
Language is the most powerful means of communication . It can manifest as spoken and/or written form . The damage on any aspect of human speech, a part of tongue movement, including (1) the production of verbal sounds, (2) speech speed, and (3) phonemes, can lead to verbal disorder . Likewise, damage to the written and...
Thirty - eight eyes of 35 glaucoma patients were enrolled in this retrospective cohort study . The patients were identified from surgical logbooks and clinical databases at department of ophthalmology, uludag university faculty of medicine . All of the patients had previously undergone viscocanalostomy for primary open...
Health of children and adolescents is an urgent public concern and the subject matter of priority in any socio - economic and political conditions, since it determines the future of the country, its intellectual, economic, scientific potential and the nation's gene pool . Health status of children and adolescents is de...
A 52-year - old woman presented with generalized tonic - clonic seizure (gtcs) at the first seizure attack . In general, she was healthy, and only suffered from mild headache in the past few months . During the night before visiting the er, she showed inappropriate behavior, confusion, and disorientation . A few hours ...
Unexplained infertility is a vexing state for the subfertile couple as the clinician is often unable to either provide definitive and demonstrable cause of infertility or provide a concrete line of management for the same . Controlled ovarian stimulation (cos) with homologous intrauterine insemination (iui) or in vitro...
Mandibular fractures in infants (younger than 1 year) are uncommon . In the 0 - 1 year age group, the frequency has been reported to range from 0.9% to 2.6%1 . In terms of treatment, pediatric mandibular fractures are treated with a wide variety of fixation methods . Although conservative treatment such as closed reduc...
The terms congenitally missing, absence, developmental hypodontia, and tooth agenesis are all expressions used to describe the failure of 1 to 5 permanent teeth to form; this is a relatively common occurrence with an incidence of 3 - 8% in the general population.1,2 with the exception of third molars, the most frequent...
The world health organization estimated from 20101 indicate that glaucoma is the second leading cause of blindness worldwide . The nigeria national blindness survey reported the prevalence of glaucoma - related blindness at 0.75% second only to cataract - induced blindness.2 glaucoma progresses slowly with few, if any,...
Ultrasound imaging (usg), computed tomography (ct), and various other imaging modalities, including nuclear scans, are increasingly being used for metastasis workup and they have greatly increased the detection of occult metastasis at various sites including thyroid . Fine needle aspiration (fna) is a sensitive techniq...
There are several forms of cell death in mammalian cells, among them apoptosis and necrosis as the two best characterized and most intensively studied modes of cell death . Apoptosis is characterized by a series of programmed events, including membrane blebbing, caspase activation, and internucleosomal dna fragmentatio...
Any drug administered in the perioperative period can cause anaphylaxis, which may be life - threatening . Neuromuscular blocking agents (nmbas) (69.1%), especially atracurium and latex (12.1%) were the most frequently involved drugs according to the most recent french epidemiological survey . A 23-year - old female pa...
The crl-2302 (arpe-19) (atcc, usa) was used for this study . These human retinal pigment epithelial cells were cultured in dulbecco's modified eagle's medium (dmem) (sigma, st louis, mo, usa), which is composed of 10% fetal bovine serum (fbs), penicillin (100 u / ml), streptomycin (100 u / ml), and nystatin (25 ug / ml...
Nowadays, researchers are focusing on the development of more acceptable bromination protocols to accomplish increasing demands for organohalogen chemistry and to achieve higher efficiency and selectivity of the bromination reactions which include -bromination and nuclear bromination . The resulting -brominated or nucl...
The potential of mean force (pmf),, as a function of a set of collective variables (cvs), x, can be formally written as1where kb is the boltzmann constant, t is the temperature, = (kbt), (z) is a delta function of z, u is the potential energy, and r is a particular configuration of the system . Clearly, the quality of ...
The major advantage of stem cell therapy is avoiding potentially harmful surgical procedures and resulting donor - site morbidity . In particular, it can reduce the surgical risk for elderly patients . The skin grafting or flap surgery indications are traumatic skin defect, severe burn, scar, skin ulcer, sore, diabetic...
The inheritance of a gene expression program that persists beyond cell division is essential to maintain lineage identity . In this regard, epigenetic mechanisms play a major role in stable gene repression, referred to as gene silencing . Although many of the factors involved in gene silencing have been identified, lit...
As part of our ongoing investigation into the c - ribosylation of (r)-prealnumycin (1) by alna, an enzyme produced by streptomyces albus (scheme 1), it was decided to test various 1,4-naphthoquinone substrates against alna in order to identify the structural motifs necessary for, or inhibitory to, reaction . Thus, we c...
Case histories, hematological investigations including hemoglobin estimation, fasting blood glucose level, impressions and photographs of the maxillary and mandibular arches were taken after obtaining informed consent from the patients . Following this, age and sex matched healthy controls, were selected randomly from ...
Poly(n - alkyl methacrylates) (pnma) constitute a versatile class of polymers that are produced on a very large scale . Upon varying the number of carbon units in the alkyl side groups (n), physical properties such as the glass - transition temperature (tg) can be tailored to range from 65 c (p12ma) up to 133 c (pmma)....