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Previously, pain has been underestimated and undertreated in children, due to individual and social attitudes toward pain and the complexity of its assessment in children [13]. Over the past decade, the importance of pain control in the pediatric population has been more widely recognized, especially as outpatient proc... |
All procedures were conducted after approval from the cary institute of ecosystem studies institutional animal care and use committee . We conducted our research in dutchess county, new york, a region where human cases of anaplasmosis are rapidly increasing . We trapped hosts on the property of the cary institute of ec... |
Mucormycosis is a devastating opportunistic infection associated with high mortality . In developing countries such as india, it is on an emerging trend due to the vast number of diabetes mellitus cases . Most of the cases occur in patients with uncontrolled diabetes mellitus and compromised immune status, and rhino - ... |
The general form of the drinfeld - sokolov - satsuma - hirota system that is going to be studied in this paper is given by (1)wt6wwx+wxxx6vx=0,vt2vxxx+6wvx=0, which was developed in as one example of nonlinear equations possessing lax pairs of a special form [24]. System (1) was independently presented by drinfeld and ... |
Pigmented villonodular synovitis (pvns) is a benign proliferative histiocytic disorder of the synovium . In 1941, jaffe et al . The disease is monoarticular and involves mainly the knee joint; the hip and ankle joints follow in frequency . The relapse rates of surgery are reported to be relatively high, ranging between... |
All membrane fusion reactions occurring during assembly and inheritance of organelles of the secretory pathway depend on two atpases of the aaa protein family, n - ethylmaleimide - sensitive factor (nsf) (sec18p) and/or p97/vcp (cdc48p) (patel and latterich 1998). Heterotypic fusion of secretory vesicles to their targe... |
Since a lymphoid tissue inducer (lti) cell was found in mouse lymphoid tissues (1), many groups have studied on its functions . Firstly, it has a key role in secondary lymphoid tissue development through the lymphotoxin-12 expression during ontogeny (1 - 5), and provides survival signals to memory cd4 t cells through t... |
The spectrum is diverse because of different phenotypes that can cause distinctive symptoms, and because cd can occur virtually anywhere in the gastrointestinal tract . Additionally, cd varies greatly in its severity it may be severe or mild, and can be clinically disabling or altogether tolerable . The occurrence of s... |
The prevalence of chronic pain among general population ranges from 10 - 46% depending upon the study population surveyed, survey method and definition of chronic pain used . In a world health organization survey of primary care patients, bihari et al ., found the prevalence of musculoskeletal pain in indian population... |
Despite intense research into acute myeloid leukemia (aml) during past decades, the majority of aml patients still die from their disease . Aml is a heterogeneous disease harboring a multitude of genetic and epigenetic changes, and it is highly likely that the various aml subtypes require different targeted therapeutic... |
While the human immunodeficiency virus (hiv) and acquired immune deficiency syndrome (aids) epidemic remains a significant global health concern, sub - saharan africa continues to be the most affected region on the globe.1 behavioral patterns in sexual relationships play a significant role in the spread of hiv / aids.2... |
In the context of bone morphology, the craniofacial region represents the most complex and special part of the body, consisting of 22 separate bones in addition to 22 deciduous and 32 permanent teeth . Most skull bones are developed from neural crest cells, where the skull vault, mandible, and maxilla are formed from i... |
Cutaneous soft - tissue sarcomas represent <1% of malignant cutaneous tumors . A review of 12, 114 cutaneous soft - tissue sarcomas showed that 2% of cases were cutaneous angiosarcomas . Cutaneous angiosarcoma mostly involves the head and neck region in 59% of cases, followed by the trunk in 25%, lower extremity in 9% ... |
A 36-year - old previously healthy woman presented with a two - month history of recurrent asymptomatic multiple symmetric erythematous - to - violaceous papules and plaques, 0.53 cm in size, with central erosion or superficial crust in some of them, located mostly on the limbs, but also on the trunk and neck (figure 1... |
Data have been collected during the population - based cooperative research in the region of augsburg (kora) s4 survey as described elsewhere (710). Briefly, in a sample of 1,653 individuals (842 men and 811 women) aged 5574 years, body weight, waist circumference, blood pressure, fasting blood glucose, triglycerides, ... |
A 55-year - old female visited the outpatient clinic of the samsung medical center for routine cancer surveillance in may 2011 . The patient received a living - donor kidney transplant eleven years ago for end - stage renal disease secondary to iga nephropathy at kyunghee university medical center . She was on stable d... |
Iron is a micronutrient essential to plants for its role in chlorophyll synthesis and several other enzymatic processes . Despite its abundance in soils, the bioavailability of iron is limited as a result of the low solubility of iron(hydr)oxide minerals, in particular in soils with a neutral to alkaline ph . Strategy ... |
Paraphilias are classified in the diagnostic and statistical manual of mental disorders (dsm - iv) as sexual disorders characterized by intense, recurrent sexual fantasies, thoughts, and/or behaviors . Diagnostic criteria for these disorders require either marked subjective distress or interpersonal difficulty . Despit... |
Endoscopic ultrasonography with fine needle aspiration (eus - fna) is a key staging and diagnosis procedure for mediastinal and gastrointestinal lesions and malignancies . Increasingly, interventional eus has been used for minimally invasive therapeutic procedures such as celiac plexus neurolysis, guide wire placement,... |
Computed tomography coronary angiography (ctca) is a non - invasive tool with high diagnostic accuracy for detection of coronary arterial stenosis (1 - 6). In retrospectively electrocardiogram (ecg)-gated spiral data acquisition mode (spiral mode), radiation exposure is high and radiation doses can be as high as 12 msv... |
With the rapid growth in available genome sequences, metagenomic data sets and the low cost of dna synthesis, oligonucleotide arrays are now a ubiquitous tool for molecular biologists and others . High - density arrays have been used to monitor mrna expression levels, determine transcript boundaries, locate protein dna... |
An increased number of bacterial tick - borne disease cases have been reported in poland in recent years ., coxiella burnetii, and rickettsia spp . Clinical symptoms of tick - borne diseases can vary, depending on the affected system (osteoarticular, nervous, gastrointestinal, or cardiovascular). Some patients do not n... |
While stimulation through the antigen receptor (signal 1) combined with costimulation (signal 2) is absolutely required for activation of t cells, it is now generally understood that additional signals are required for acquisition of full effector function . These additional signals, in the form of autocrine and paracr... |
Cohort origin - the population of b. ferroae used in this study was collected in santa catalina, toledo, north of santander, colombia (0707'n 7224'w). Experimental procedures - the experiment was carried out in a climatically controlled room with a constant temperature (25 2c), humidity (70 10% rh) and photoperiod (12:... |
Cotton, gossypium hirsutum l., is grown worldwide primarily as a source of fibre for textile manufacturing and brazil is one of the largest producers in the world . However, the production of this commodity is highly affected by large losses caused mainly by insect - pests, such as anthonomus grandis (coleoptera: curcu... |
A total of 398 and 865 nonduplicate s. aureus isolates were collected from march to may 2000 from 21 hospitals and from july to september 2002 from 26 hospitals, respectively, as part of the tsar collection (11). The proportions of isolates for the 2 years were similar for outpatients (27.5% in 2000 and 28.9% in 2002);... |
He had a medical history of laparoscopic cholecystectomy, performed 18 years ago for symptomatic gallstones . History of presenting illness was negative for diarrhoea, abdominal pain, tarry stool, weight loss or dizziness . Since the cholecystectomy, he had no symptoms of post - cholecystectomy syndrome . On examinatio... |
The outcome of the pulmonary infection is divergent and can range from the complete pathogen clearance through asymptomatic latent infection (ltbi) to active tb disease . Ltbi has long been considered as a uniform state characterized by the immunological sensitization in the absence of clinical signs and symptoms of ac... |
We statistically examined diagnostic records of 8,848 dogs sampled in the eastern crete districts of lasithi and heraklion during 19902006 . Data were supplied by the faculty of medicine, university of crete (n = 1,205 dogs from 97 villages tested by using an indirect immunofluorescent antibody test [ifat], cutoff tite... |
It is a major health problem, brings much morbidity, early mortality and great deal of misery for a family both financially and emotionally . Patients with thalassemia major should receive blood transfusion regularly to maintain optimal hemoglobin (hb) level . Such transfusion will increase exposure to hepatitis b viru... |
The beneficial effect of icd in patients discharged after an acute mi is even more controversial when considering with accuracy the results of published studies . This issue has been the object of renewal interest after the publication of the results of the dinamit study (7). More than six hundred patients with a recen... |
Chilaiditi syndrome is a rare condition characterized by the transposition of a loop of large intestine (usually transverse colon) in between the diaphragm and the liver, visible on plain abdominal x - ray or chest x - ray . This anatomical variant is sometimes mistaken for the more serious condition of having air unde... |
Vaginal tumors are rare and include papilloma, hemangioma, mucus polyp, and rarely leiomyoma . Vaginal leiomyomas remain an uncommon entity with only about 300 reported cases since the first detected case back in 1733 by denys de leyden . Bennett and erlich found only nine cases in 50,000 surgical specimens and only on... |
The revolution of next - generation sequencing methods has led to a surge in the number of phylogenetic studies incorporating an unprecedented number of genes (mccormack et al . Many methods have emerged as being very amenable for phylogenetic applications that target non - model taxa . These methods are aimed at seque... |
Seasonality is noted in various aspects of human behavior and functioning which have led to an increasing interest in their seasonality in the recent years . Rectal foreign body insertion has been extensively described in the literature, with the earliest description dating back as long as the sixteenth century (haft a... |
The incidence of non - tuberculosis mycobacterial (ntm) infection has increased recently, and this condition currently accounts for 10%15% of all mycobacterial infection cases.1,2 while the mycobacterium avium complex (mac) and m. kansasii are responsible for more than 90% of cases of mycobacterial infection, mycobacte... |
Edwards syndrome (trisomy 18), first described by edwards et al . 1 in 1960, is the second most common autosomal trisomy, after trisomy 21 . It consists of craniofacial anomalies, visceral defects, and delayed mental and motor development . The survival rate beyond the first year of life is 510%, with a livebirth preva... |
Health care - associated infections (hais), which the centers for disease control and prevention (cdc) estimates occur in one of every 25 acute care hospitalizations,1 are of paramount interest in the us . Hais in hospitals tracked by the cdc1 include central line - associated bloodstream infections (clabsis), catheter... |
The hydrophilicity of the impression materials is critically crucial to wet the hard and soft - tissues in the mouth and to create accurate impressions and casts . During making the impression, the material needs to flow and adhere to the tooth structure and periodontal tissues that may be wetted by blood, saliva, and ... |
Even though native arteriovenous fistulas (avfs) are considered the best vascular access option for hemodialysis (hd),1 tunneled - cuffed catheters (tccs) are the initial access for 80% of patients in the usa2 and 30% of patients in europe starting hd.3 in fact, for patients with end - stage renal disease (esrd) admitt... |
Cardiovascular disease is the leading cause of death worldwide . From 1990 to 2010, the prevalence of cardiovascular circulatory diseases has risen by 31% contributing to over 15,616,000 deaths worldwide in the year 2010 . Specifically with the prevalence of cardiomyopathies rising by 40%, early diagnosis is critical i... |
Ductal carcinoma in situ (dcis) of the breast is a noninvasive carcinoma with a wide spectrum of disease, ranging from low - grade to high - grade malignancy with foci of invasive malignancy . Histologically, dcis is characterized by a proliferation of malignant cells in the ductal epithelium that are confined to the b... |
Over 300 proteins require zinc for their functions in microorganisms, plants, and animals . Extracellular zinc concentration in the adult brain is estimated to be less than 1 m . Zinc concentration in the cerebrospinal fluid (csf) is approximately 0.15 m, while that in the plasma is approximately 15 m . Zinc transport ... |
Stroke is the leading cause of long - term disability among adults in developed countries, and aphasia is one of the most common and devastating cognitive impairments of stroke (1,2). About 21 - 38% of acute stroke patients experience aphasia (2, 3), and in the majority of cases the left perisylvian areas are damaged (... |
Investigating and understanding its predictors can be a great step forward in disease prevention and treatment . An acute myocardial ischemia provokes an inflammatory response that increases myocardial damage, but on the other hand it promotes regenerative process . This process is a consequence of endothelial progenit... |
Haploidentical stem cell transplantation (haplo - sct) is an alternative treatment for transplant candidates lacking a human leukocyte antigen- (hla-) matched related or appropriate unrelated donor . After hematopoietic stem cell transplantation (hsct), t cells are regenerated through thymic and peripheral pathways, wi... |
Endocannabinoids (ecbs)such as anandamide (aea) and 2-arachidonoylglycerol (2-ag)are lipophilic molecules that work as integral part of the endocannabinoid system (ecs), mimicking several actions of -tetrahydrocannabinol (thc), the active principle of cannabis sativa . Although the existence of an intracellular recepto... |
Protein - protein interactions (ppi) are of central importance for virtually every process in a living cell . For example, information about these interactions improves our understanding of diseases and can provide the basis for new therapeutic approaches . One of fundamental goals of system biology is to understand ho... |
Changes in modern societies were driven by several factors, namely economic and cultural globalization, scientific and technological progress, increased access to information, or the acknowledgement of consumers rights . All these changes originate the perception that ethical behaviour is essential in organization s pr... |
Strokes can cause a combination of motor, sensory, cognitive and emotional impairments resulting in impairment of balance and gait ability in patients as well as impairment of the activities of daily living (adl)1 . The major goals of rehabilitation in stroke patients are improving balance and gait ability2 . Balance i... |
It is the fourth most frequent cause of cancer - related deaths in north america, the sixth in europe, and the fifth in the uk . Beside surgery and chemotherapy, cyclooxygenases (cox)the constitutive (cox-1) and the inducible (cox-2)have been investigated as targets for treatment and prevention of pancreatic cancer sin... |
Stress, a psychosocial factor affecting work health and work productivity, is an important public health problem today (1, 2). Work stress is an employee health problem that negatively affects the health of workers, disturbs public peace, and may cause harmful results for employee and employer . Work stress affects 22%... |
Improvement in motor disorders in parkinson s disease (pd) involves drug and rehabilitation therapy, in which physiotherapy activities are of major importance . According to this premise, physical therapy for people with pd prioritizes the execution of isolated motor tasks at all stages of the disease, especially when ... |
Citrus is one of the most important and widely grown of the fruit crops, with total global production reported to be 105.4 million tons in 2004 - 2005 . Citrus fruit is produced throughout the tropical and subtropical regions of the world, where the winter temperatures are adequate for tree survival and avoidance of fr... |
A rapidly growing interest in self - standing nws of iii v compound semiconductors is explained by an interesting physics of their growth [1 - 6], crystal structure transport and optical phenomena as well as a variety of promising applications in nanoelectronics and nanophotonics . Iii v nws with radii of the order of ... |
Over the last decade significant advances in diagnosis and treatment of renal tumors were made mostly due to the universal access to imaging modalities like ultrasonography, computed tomography (ct) as well as magnetic resonance imaging (mri). As a result, detection rate of incidental tumors (often less than 4 cm in di... |
It accounts for 80% of all noncutaneous melanomas . Up to 50% of uveal melanoma patients die from metastatic disease within 10 years of initial diagnosis and it accounts for 13% of all deaths caused by melanoma [1, 2]. Therefore, it is an urgent necessity to develop more efficient and novel therapeutic agents for impro... |
The human foot posture is generally characterized by the alignment of the foot skeleton, and it varies considerably between individuals . Variation from a normal foot posture has long been thought to influence the function of the foot and lower limb during gait, thereby predisposing them to injury1 . While the link bet... |
Maternal use of frusemide had been tried to induce fetal diuresis to help differentiating fetuses with non - functioning kidneys from those suffering from severe placental insufficiency . Maternal frusemide causes a transient increase in the fetal urine production and consequently a small increase in the amniotic fluid... |
A 79-year - old man developed persistent right eye blindness after multiple episodes of transient left hemiparesis and right eye amaurosis . Brain computed tomography angiography (angio ct) disclosed right internal carotid artery (ica) plaque with a 8 mm thrombus extending from ica origin to the ophthalmic artery (figu... |
Authors do not have any financial relationships associated with this study . As no animal data, human data, or studies were acquired or used, the present study was exempt from institutional review board approval . We used a 30 cm 20 cm 10 cm (transverse diameter anterior posterior diameter length) anthropomorphic chest... |
This still leaves the question: given the impossibility of teaching the entirety of the natural and social sciences in the year or two of courses to which we expose our students, what knowledge and analytic skills should we be imparting? First come the standard tools of policy analysis: cost / benefit and risk analysis... |
Spinal cord injury (sci), one of the most severe injuries, causes the death of many kinds of cells such as neurons, oligodendrocytes, and astrocytes, in which extensive loss of sensory and motor functions occurs below the injury site . Two different mechanisms have been proposed for the pathogenesis of sci: a primary m... |
Aesthetic failure is one of the most common reasons for the replacement of restorations . A good combination of the tooth colour and the initial colour of the material before curing is an important clinical factor for a successful outcome . Nonetheless, this combination must remain after the material is completely cure... |
Varicocele, a common disease that affects men, is the elongation and tortuousity of the spermatic veins [1, 2]. It is estimated that 15% of men have varicocele of different grades . Moreover, 19% to 41% of men with primary infertility, and 45% to 81% of men with secondary infertility suffer from varicocele . Although v... |
Electrical cardioversion is effective in about 8695% of patients [13]. In patients with an implantable cardioverter - defibrillator (icd) only limited data are available on the efficacy of internal icd cardioversion for af . In the present study from our prospective electronic icd database we retrospectively identified... |
Tuberculosis (tb) is the leading cause of death among infectious diseases 1, 2 . Although about one third of the world's population is thought to be infected with mycobacterium tuberculosis (mtb), only 5 - 15% of people develop clinically active tb during their lifetime 3 . This indicates that genetic differences betwe... |
For many decades, the existence of myocardial iclcs interstitial cajal - like cells (iclcs) has been either ignored or overlooked . As recently stated, iclcs were mainly neglected due to the physical constraints of light and/or electron microscopy methodology. . This study was then followed by an ascending trend of pub... |
Thermophilic campylobacter species, particularly campylobacter jejuni and campylobacter coli, have been recognized as a major cause of acute bacterial gastroenteritis in humans since 1970 and it is estimated that campylobacter spp . Are responsible for 400500 millions cases of diarrhea each year worldwide [14]. In deve... |
Cryptococcosis is a symptomatic fungal infection with worldwide distribution caused by cryptococcus, which frequently occurs in patients who are immunologically compromised or chronically ill 1, 2 . Clinical manifestations are usually confined to the central nervous system, lung and skin, whereas localized involvement ... |
Cachexia sarcopenia and general wasting of the musculature are related to a poor quality of life and increased morbidity / mortality . They are caused by a large number of chronic diseases and the general process of aging thus affecting millions of patients and elderly [24]. The syndrome of cachexia is characterized as... |
Studying the passage over a transition state in enzymatic reactions remains a formidable task . There are two main approaches, one that employs variational transition state theory (vtst), with the main focus on calculating the free energy to reaction, and transition path sampling (tps), with the main focus on analyzing... |
With a pediatric population that constitutes nearly 40% of the 1000 million people in this country, the potential for growth of pediatric neurosurgery as a subspecialty would be enormous by any standard . Despite this, however, the state of pediatric neurosurgery in india has been far from satisfactory in the past . It... |
Multiple experimental and clinical studies demonstrate a similar origin and development of hyperplastic and inflammatory processes in breast tissue of both men and women . The term mastitis has been used to describe infectious and aseptic breast tissue inflammation . Granulomatous mastitis (gm) is a chronic form of the... |
Pseudoexfoliation (pex) syndrome is an age - related systemic disease of the extracellular matrix characterized by the widespread deposition of an abnormal extracellular fibrillary material on many intra- and extraocular tissues . It is widely recognized that this syndrome is associated with severe chronic secondary op... |
The main physiological role of skeletal muscle mitochondria is to produce atp from oxidative phosphorylation . Importantly, skeletal muscle mitochondria play a specific role in exercise capacity, aging, degenerative disease and type ii diabetes . As an aging society, and type ii diabetes being the 7 leading cause of de... |
However, it is also well known that ptc frequently metastasizes or recurs to regional lymph node . The central compartment was located adjacent to the thyroid and can be dissected through the same wound as that for thyroidectomy . Therefore, routine central node dissection for ptc has been performed in many institution... |
Electrophoretic mobility shift assay (emsa)tc3, min6, hela, and nih3t3 cell nuclear extracts (ne) were prepared using lysis buffer (100 mm tris - hcl, ph 8.0, 0.5% igepal ca-630 (sigma - aldrich), 2 mm sodium orthovanadate, 2 mm sodium fluoride, and protease inhibitor mixture (roche applied science)), followed by pelle... |
Collagenofibrotic glomerulopathy (cg) is a rare condition characterized by deposition of type iii collagen fibers in the subendothelial space and mesangium of the glomerulus . It was initially considered as a variant of nail patella syndrome in view of similar histological findings but without skeletal abnormalities . ... |
We recruited pd patients and healthy volunteers who visited the department of neurology at hallym university sacred heart hospital . Pd patients had either asymmetric or unilateral motor symptoms . To investigate the correlation between motor deficit severity and n30 responses on the more - severely affected side, we s... |
In this review we consider the problem of detection of deterministic gravitational - wave signals in the noise of a detector and the question of estimation of their parameters . The examples of deterministic signals are gravitational waves from rotating neutron stars, coalescing compact binaries, and supernova explosio... |
It is an established fact that high body mass index (bmi) is protective of osteoporosis 1 . An increase in bmi is often associated with improvement in bone health, as assessed by bone mineral density and calcaneal quantitative ultrasonography 2, 3 . This is attributed to the ability of our skeletal system to adapt to c... |
Bariatric surgery for weight loss in the morbidly obese is a common, major upper abdominal operations currently performed in north america . Following surgery patients are often concerned to know how their weight loss compares to that of other patients . Various factors are known to influence weight loss after surgery ... |
The pelvic floor musculature (pfm) is a muscular layer that supports the pelvic organs . Pfm function (pfmf) depends on the anatomical position of the muscles, the resting tone, and on the integrity of the fascia . When there is an increase in intra - abdominal pressure (iap), e.g., during coughing, the pfm must contra... |
Balance refers to the adjustment of position in active movements and the maintenance of an appropriate position in response to external stimuli . The maintenance of balance requires normal pressure and an appropriate integration process at the higher center with continuity of the center of gravity within the support pl... |
Since antibodies were first described late in the 19th century, antibodies have become the single most highly recognized mediators of immunity . During the past century, the general public has also become familiar with the practice of passive immunization for the treatment of a variety of infections that include tetanu... |
The present paradigm is that hantaviruses in the americas cause hantavirus pulmonary syndrome (hps), while hemorrhagic fever with renal syndrome (hfrs) is caused by hantaviruses present in eurasia [13]. Hantaviruses associated with hfrs and hps are primarily transmitted by inhalation of viral particles shed by infected... |
Melatonin (mlt) is an indoleamine produced by the pineal gland that controls the circadian cycle and acts as a neuromodulator, cytokine, and biological response modifier . This hormone is widely known as an adjustor of the reproductive physiology to the environmental light in seasonally dependent mammals . Mlt also has... |
It causes diarrhoea with fever and abdominal pain, and in many cases the infection resolves spontaneously 1,2 . However, complications such as bacteraemia and post - infection sequelae such as guillain barr syndrome (gbs) and reactive arthritis may occur 3 . There is an increasing body of evidence indicating that the s... |
A 35-year - old male patient was admitted with headache, visual disturbance and left hemiparesis . He had no history of hypertension, diabetes mellitus or other cardiac disease, and he was currently a 10-pack - per - year smoker . The neurological examination results were normal, although he complained of numbness in h... |
A 52-year - old man with significant history only of remote non - injection drug use presented with neck pain, 2 weeks of mild fevers, chills, night sweats, unintentional weight loss, dyspnea, and dry cough . On physical examination, he appeared non - toxic with poor dentition . Magnetic resonance imaging done for the ... |
Cochlear implantation has become the standard treatment for patients with severe to profound sensorineural hearing loss . Moreover, cochlear implantation has been shown to be safe in young children, and is now commonly performed in children younger than 2 years of age (1, 2). However, revision cochlear implantation are... |
A beautiful smile adds beauty to the face and, in today's world, everyone wants to look beautiful . The increasing esthetic demands of the patients have led clinicians to think more about the facial and dental esthetics . Although function, esthetics, and stability are equally important from the point of an orthodontis... |
Malaria is an infectious disease transmitted by the anopheles mosquito and is caused by plasmodium protozoan parasites . The disease is common in many tropical and subtropical areas of the world and is considered as an important life - threatening factor for people living in these regions . A total of 109 countries are... |
Fatty acids play a complex role in the physiology of insulin secretion and also participate in the disruption of -cell function and mass that leads to type 2 diabetes . Exposure of -cells to fatty acid in vitro and in vivo has a biphasic effect . Acutely, exposure to fatty acids does not stimulate insulin release; rath... |
Corticosteroids, usually prednisone, are often the first - line treatment for itp . However, about 70% of adult patients experience a relapse after the discontinuation of corticosteroids . Moreover, approximately 20% to 30% of chronic itp patients do not respond to corticosteroid therapy [1, 2]. Rituximab has been prov... |
Ca 72 - 4 is a glycoprotein found on the surface of tumor cells, with a weight of 200420 kda . The tumor spectrum in which it is grown includes, besides gastric cancer, pancreatic, ovarian, breast and colorectal tumors . Normal value (depending on the laboratory technique): <6.9 u / ml . The overall sensitivity of this... |
Since the early 1980s, fungi have been known as one of the important causes of human infection diseases, especially among immunocompromised individuals (1, 2). The morbidity and mortality associated with these infections are considerable (3, 4), so it is obvious that fungal diseases are important public health problems... |
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