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Lipid nanoparticles (lnp) are the leading delivery systems for enabling the therapeutic potential of sirna for systemic applications . Lnp sirna systems containing optimized ionizable cationic lipids can exhibit remarkable in vivo potencies at doses as low as 0.02 mg sirna / kg body weight for silencing liver (hepatocy... |
Many proteomics experiments are performed on the peptide level (namely, bottom - up proteomics). For this purpose, the proteome is enzymatically digested, and the peptide and peptide fragment masses are measured by tandem mass spectrometry after online separation by reverse - phase liquid chromatography (lc ms / ms). F... |
Ankylosing spondylitis (as), an inflammatory arthritis of the spine, is the prototype hla - b27-associated seronegative spondylarthritis.1 although several studies have examined the pathogenesis of as, the disease is not yet completely understood . Paraoxonase (pon), an enzyme produced by the liver, is associated with ... |
For the surgical treatment of stage ib1 cervical cancer, open radical hysterectomy with pelvic lymph node dissection has been the gold standard for over 100 years and has undergone little modification since it was first described by wertheim and later by meigs . Techniques for laparoscopic radical hysterectomy and lymp... |
The inappropriate disposal of dyes in waste water constitutes an environmental problem and can cause damage to the ecosystem wastewater containing dyes cause water pollution by lowering light penetration and photosynthesis and toxicity from heavy metals associated with pigments . Synthetic dyes are widely used in indus... |
We report the presentation and management of a single case of human toxicity of sodium chlorite . A 65-year - old man presented to hospital after accidentally ingesting a small amount of a sodium chlorite solution . His principal manifestations were mild methemoglobinemia, severe oxidative hemolysis, disseminated intra... |
Adenomatoid tumors, although rare, are the most common tumors of the paratesticular tissues, accounting for approximately 30% of all paratesticular tumors . In men, they are located in the epididymis, testicular tunicae, and rarely, the spermatic cord with most arising in or adjacent to the lower or upper pole of the e... |
Proton pump inhibitors (ppis) potently inhibit gastric acid secretion, and are widely used for prevention and treatment of various acid - related diseases including peptic ulcers and gastro - esophageal reflux diseases . Although their acid inhibitor potency is far stronger than that of histamine h2 receptor antagonist... |
We recruited 17 current and 17 ex - smokers with copd to form our study sample . Copd was diagnosed according to the gold criteria.1 participants were allowed to have any degree of bdr following inhalation of 200 g salbutamol, but no history of asthma as confirmed by two physicians independently . Smoking intensity was... |
Previous studies found interactions between the meaning of words and the screen location where the words were presented (i.e., spatial position). For instance, people were faster to decide that a stork flies if the word stork was presented at the top of the screen rather than at the bottom of the screen (eti and domija... |
Bioresorbable scaffolds (brs) have been designed to overcome problems related to the long - term persistence of metallic stents implanted in coronary arteries . Several randomized controlled trials (rcts) comparing polymeric brs with new - generation drug - eluting stents (des) found similar clinical outcomes at 1 year... |
Swine have served as an important biomedical model for humans for decades; previous authors have summarized such models in more detail 1 - 5 . Limitations on reference citations for this review has meant that only the most recent will be cited to cover the latest developments and the broadest range of current pig model... |
Fabrication of a natural looking restoration is one of the challenges in esthetic dentistry because shade matching with natural teeth is a difficult task due to the complicated optical properties of teeth.1 an esthetic restoration should reproduce morphologic, optical, and biologic characteristics of teeth under varied... |
Nonvalvular atrial fibrillation (nvaf), a treatable risk factor for ischemic stroke, is considered a worldwide epidemic predicted to increase in the coming decades . Indeed, in 2010, the estimated global prevalence of af was 33.5 million.1 oral anticoagulation is the cornerstone treatment for nvaf patients with a moder... |
Illness associated with infection with mers - cov is characterized primarily by mild - to - severe respiratory complaints, most requiring hospital admission for pneumonitis or acute respiratory distress syndrome . As of june 11, 2015, ecdc has reported 1,288 laboratory - confirmed cases, including 498 deaths (1). Overa... |
A common upper airway and digestive tract is a rare congenital anomaly that is usually fatal and exact incidence of which is not known . The diagnosis is assumed to be made if there is inability to perform endotracheal intubation of a newborn with respiratory distress in an expert hand in a neonate not cried at birth .... |
Hiv infection induces a deficient immunologic milieu that enables other oncogenic viruses such as ebv to escape immune control in a multifactorial way, which can lead to the onset of lymphoma . The incidence of hiv - related pcnsl has decreased since the widespread introduction of haart . Presentation of the disease is... |
A prospective analysis was carried out in amrita institute of medical sciences, kerala which is a tertiary care hospital, to compare the outcome of hemodialysis patients from different socioeconomic status . Patients were allotted in different shifts either in morning, afternoon or evening, based on their preferences .... |
Malignant lymphoma (ml) can involve the central nervous system either primarily or by secondary spread, which tends to occur late in the disease as part of widespread dissemination8,18). The rate of epidural mass formation in all cases of mls is 0.8 - 2.86,14,19,21). Owing to this rate of occurrence, a small number of ... |
Japanese encephalitis virus (jev) is a mosquito - borne microorganism that causes encephalitis in humans and reproductive failure in pregnant sows . Jev has been recently recognized as a reemerging pathogen as it has expanded into new territories such as the torres strait and australia [5,10,18 - 20]. Based on a sequen... |
Loss of primary teeth with severe injuries to the surrounding bone will also interfere with the normal growth and development . Some severe forms of dentoalveolar injuries associated with the loss of multiple primary teeth would result in large bone defects, healing of which is often complicated . Such injuries would r... |
Usually, gartner's duct cysts are on the anterolateral vaginal wall and its chances of being present on the posterior vaginal wall are relatively rare . Its incidence of all the vaginal cysts is 12.5% . As it may arise from remnants of wolffian duct vaginal cyst can be histologically classified as epithelial, inclusion... |
Nephron - sparing surgery (nss) offers equivalent oncologic control, as does radical nephrectomy in patients with appropriately selected stage t1 renal tumors [1, 2]. Additionally, nss has been associated with decreased risks for renal impairment [35] and cardiovascular events [6, 7], which may explain the improved ove... |
In the early days of biological research, mutations that caused discernable phenotypes were the primary tool for understanding how a biological system worked in the absence of a mutation a gene was invisible . Today, biologists are armed with a whole arsenal of tools to regulate gene, mrna, and protein abundance and ac... |
However, a few reports have described esophageal injury after pvi, including the development of lethal atrioesophageal fistulae . In addition, periesophageal nerve (pen) injury after pvi may rarely cause pyloric spasms and gastric hypomotility . The c - acetate breath test has been used to diagnose delayed gastric empt... |
Various glomerular diseases can be caused by the deposition of monoclonal immunoglobulin g (igg). Renal disease related to the deposition of monoclonal igg containing both heavy and light chains can occur in type 1 cryoglobulinemia, randall - type light- and heavy - chain deposition disease (lhcdd), light- and heavy - ... |
The relationship between inflammation and hypertension has been investigated for many years.1) experimental studies have shown that inflammatory cytokines contribute to hypertension by increasing vascular tone and impairing endothelial function . The relationships between hypertension and high - sensitivity crp (hs - c... |
Although an increasing number of studies indicate that primary brain tumors and their treatment are often associated with cognitive deficits, there is still limited knowledge about their incidence, nature, severity, and causes . Since patients with diffuse infiltrative gliomas (who grade 24) cannot be cured, palliation... |
An opaque bubble layer is a rare complication of femtosecond laser - assisted in situ keratomileusis (lasik), which occurs during intracorneal femtosecond laser ablation when gas bubbles are produced and trapped in the corneal interface.1 although intraoperative complications concerning the opaque bubble layer are not ... |
Giant cell tumor (gct) accounts for about 7 to 10% of all cases of primary spinal tumors . Patients with gct are usually diagnosed in the third or fourth decade of life, and there is a slight female preponderance152325). Gct usually occurs in the metaepiphyseal ends of the long bone, and it rarely occurs in the spine26... |
Integrating sensory information and producing the appropriate motor output are the basic functions of the nervous system, and the neural networks underlying these two functions are tightly linked . The basal ganglia are involved in various functions, including motor learning, planning, and execution, as well as in deci... |
Renal transplantation prolongs survival and improves quality of life for most patients who require renal replacement therapy . . Epstein - barr virus (ebv), cytomegalovirus (cmv) and varicella zoster virus (vzv) can all cause serious illnesses in transplanted patients . The spectrum of illness caused by ebv ranges from... |
The synthesis of -amino acids has been a subject of great interest and importance for quite some time but especially because it was discovered that -peptides derived from -amino acids have many of the properties of -peptides but are much more proteolytically stable . There has been a decided uptick in the efforts to de... |
Death by suicide is a leading cause of death,1 and initiatives to advance suicide prevention programmes are a high priority in many countries.2 harmful alcohol use has been recognised as a strong risk factor for suicide death.2 in psychological autopsy studies, alcohol use disorder was strongly associated with suicide ... |
Purulent conditions of the mediastinum and lungs spread by continuity through the interfascial spaces of the neck are among the rarest complications of odontogenic inflammatory processes of the oral cavity . Descending necrotizing mediastinitis (dnm) is a noteworthy example of such infection, originating from inflammat... |
Cervical cancer represents the third most common cancer in women worldwide, with 86% of all deaths occurring in developing countries, where there is lack of access to prevention, early diagnosis and treatment (jemal et al ., 2011). In brazil, cervical cancer ranks as the second most frequent cancer among women between ... |
Hypercalcemia, syndrome of inappropriate secretion of antidiuretic hormone, cushing's syndrome, and skeletal - connective tissue syndromes are common in patients with lung cancer, especially those with small cell lung cancer (sclc). Approximately two thirds of sclc patients present with metastatic stage at the time of ... |
Calcinosis cutis is the pathologic deposition of insoluble calcium salt in the skin and subcutaneous tissue . It is classified into four main subtypes: dystrophic, metastatic, idiopathic, and iatrogenic . Dystrophic calcinosis cutis follows inflammation, infection, connective tissue diseases, and so on . Complications ... |
Several antibiotic or antimicrobial agents have been tested including chlorhexidine, povidone - iodine, and fluoride mouthrinses.2 another approach to bacterially- mediated diseases has been the use of probiotics which has been defined as bacterial cultures or living micro - organisms which upon ingestion in certain nu... |
We initially studied 90 patients (age 21 years) who had newly diagnosed all and were enrolled on the st ., we subsequently studied an additional 170 patients with all enrolled on the same treatment protocol, using publicly available snp data we had previously reported . Jude children s research hospital, and informed c... |
For well over a decade, the cost of in vitro and in vivo screening of absorption, distribution, metabolism, excretion, and toxicity (adme / tox) properties of molecules has motivated efforts to develop various in silico methods to efficiently pre - filter candidates for actual physical testing . By relying on very larg... |
Interictal depressive symptoms, and interictal major depressive episodes, are quite common in epilepsy in general but appear to be particularly linked to tle . This link between these two disorders has been a source of great interest to both neurologists and psychiatrists for many years and has generated an expansion o... |
Timely immunization receipt is commonly assessed by up - to - date (utd) rates for a combination of vaccine series, such as the 4: 3: 1: 3: 3: 1 series recommended between birth and 18 months of age by the american academy of pediatrics (aap) and the advisory committee for immunization practice (acip). The 4: 3: 1: 3: ... |
Substrate proteins were expressed with c - terminal his6 tags, and assayed in 50 mm tris, 50 mm k acetate, ph 8.0, with 100 m sam as the methyl donor . All reactions were incubated 1 h at 30c and analyzed for methylation by immunoblot . For elisa assays, reactions were incubated as above then transferred to protein a -... |
The following genetically modified mice and crosses between them were used for electrophysiological analysis: nestin - gfp (cb57bl/6 background), pv - cre (jax laboratory; stock number: 008069; stock name: b6;129p2-pvalb / j), sst - cre (jax laboratory; stock number: 013044; stock name: sst / j), vip - cre (jax laborat... |
The mdc cohort is a population - based prospective cohort including 28,449 participants, with baseline data collection conducted throughout the years 199196 (22). The study population includes individuals born during 192350 (23) and living in malm, the third - largest city in sweden, with about 295,000 citizens . The p... |
We report a 10-year - old girl with multiple vasculitic skin lesions and foot drop without the usual history of asthma or sinusitis which later proved to be css on biopsy . A previously healthy 10-year - old arab girl presented with bilateral asymmetrically distributed multiple tender and nonblanching erythematous skin... |
Diagnostic laparoscopy is often used to identify specific intraabdominal pathology as the cause for chronic abdominal and pelvic pain . However, few studies have determined that laparoscopic adhesiolysis, as the only operative intervention, ameliorates a significant amount of chronic abdominal pain . Furthermore, only ... |
The specific targeting of nanoparticles to target cells in an organ of interest has been a long - term goal of many laboratories interested in using nanoparticles to mediate the functional delivery of biopharmaceutical agents (including nucleic acids) to defined target cells . One of the main problems in using targetin... |
Conventional x - ray diagnosis is a significant source of radiation exposure among the population . Therefore, there is the need for x - ray examinations to be conducted using techniques that keep the patients exposure as low as possible, but does not compromise on image quality . To be able to keep doses as low as rea... |
Normal cells grow and divide in an ordered fashion, in accordance with the cell cycle . Defective apoptosis (programmed cell death) which results in enhanced growth describes most cancer cells . Several proteins control the timing of the events in the cell cycle, which is tightly regulated to ensure that cells divide o... |
We encountered a woman with a preexisting large focal nodular hyperplasia (fnh) of the liver, persisting during two separate pregnancies . Her elevated serum -glutamyltransferase and alkaline phosphatase levels before pregnancy were reduced during both pregnancies, but returned to prepregnancy levels after delivery . F... |
Disturbed calcium metabolism may play an important role in the patho - physiology of essential hypertension . Ionized calcium (ca) acts as an intracellular second messenger in excitation - contraction coupling in vascular smooth muscle (vsm) cells . The free intracellular calcium concentration determines the tension in... |
In recent years, there has been an increasing interest in applying multivariate pattern (mvp) analysis to neural data, especially from functional magnetic resonance imaging (fmri; haynes and rees, 2006; norman et al ., 2006; o'toole et al ., 2007), more than a decade after the first application in studies employing pos... |
Rett syndrome (rtt) is a rare form of autism spectrum disorder (asd), which mostly affects girls with worldwide prevalence rate ranges from 1: 10,000 to 1: 20,000 live births [15]. Rtt is a clinically defined condition with a large spectrum of phenotypes associated with a wide genotypic variability [6, 7]. Classic or t... |
Fanconi syndrome (fs) is a rare disease characterized by defects in proximal tubular function, including impairment of reabsorption of solutes such as glucose, uric acid, phosphate, amino acid, and bicarbonate . Patients with fs may present normoglycemic glycosuria, low molecular weight proteinuria, hypophosphatemia, a... |
In orthodontic treatment, tooth movement is related to the response to applied orthodontic forces that cause remodelling of the periodontal tissues, especially alveolar bone . The typical 2- to 3-year treatment period is burdensome for patients, so it is very important to accelerate alveolar bone remodelling during tre... |
Breast cancer is an increasingly visible disease, and a rapidly growing cause of mortality, in developing countries . In africa, where breast cancer may often present at an earlier age and can progress more aggressively [2, 3], little is known about pathways and triggers for women to take action (e.g., seek medical adv... |
Participants consisted of 4 students who attended two special education schools at the elementary level . All students were diagnosed as having adhd, and their age range was between 9 to 11 years . Three of the four students were diagnosed with a combined type of adhd, and one person was diagnosed to have the hyperacti... |
A prospective case series of 10 patients was conducted by the national university hospital, diabetic foot team, in singapore . The study population was made up of six males and four females with a mean age of 54 (range: 3766 years). In this study, the indications for usage of renasys go included ray (toe and metatarsal... |
While public health and biodefense often have overlapping elements, the capabilities needed to support each mission are not identical . Thus, the dhs scientific response to ebola required initial investments of time and resources to develop additional capabilities and protocols, contributing to the time lag in obtainin... |
A 58-year - old woman presented to the emergency department with a stuporous mental state, ophthalmoplegia, and severe dysarthria . She had a prior history of cardiac valve replacement surgery for both mitral and aortic regurgitations 10 years earlier . Her national institutes of health stroke scale (nihss) score was 1... |
Zoon's balanitis or balanitis circumscripta plasmacellularis is a benign chronic disease of unknown origin . Zoon's balanitis, unlike some other inflammatory penile dermatoses, is generally not thought to be a precursor for neoplasia . We herein report the case of an uncircumcised man, who developed clinically and hist... |
The genomic revolution raised expectations of unprecedented advances in health care,1,2 but actual scientific progress remains constrained by the double bind of limited available empirical data and concerns over human safety in research . Failure to address this issue could result in general disappointment over inadequ... |
Purified herba epimedii extract (chuan - ke - zhi, ckz), a chinese medicine preparation, has already attracted more and more attention in recent years for its curative effects on respiratory system diseases, such as bronchial asthma, chronic bronchitis, and chronic obstructive pulmonary emphysema [14]. And this purifie... |
In 2006, an unidentified respiratory disease occurred in rhesus monkeys (macaca mulatta) at a breeding farm in the guangxi zhuang autonomous region in southern china . The farm, the largest in china, comprised 31,260 monkeys, of which 1 in 5 was unweaned . The morbidity rate in young monkeys was 60%, with an 30% death ... |
Warts are benign epithelial neoplasms of the skin and mucosa resulting from human papillomavirus (hpv) infection . They are a common dermatologic complaint, with an estimated incidence of 10% in children and young adults (1). Even if disease progression is naturally self - limited, the course of the disease is unpredic... |
During our continuing search for structurally unique secondary metabolites from marine dinoflagellates, we have isolated a series of cytotoxic macrolides, amphidinolides, as well as long chain polyhydroxyl metabolites from dinoflagellates amphidinium sp . . (strain number y-52), which was isolated from the inside cells... |
Acute aortic dissection is defined as the rapid development of a false, blood - filled channel within the tunica media of the aorta . Three acute aortic dissections are ultimately diagnosed out of every 1000 emergency department patients presenting with acute back, chest, or abdominal pain . Mortality in untreated acut... |
Recent advances in nanotechnology have enabled the development and use of carbon nanotubes as field - effect transistors (cntfets). These devices have advantages over traditional metal oxide semiconductor transistors, including higher circuit integration,1 increased gain, and higher mobility.2 the device consists of a ... |
Although four major models are presently being debated, only the out - of - africa suite has received strong support from interpretations of both the fossil record and dna [16]. Yet, the evolutionary origin of aboriginal australians remains controversial owing to the presence of considerable variability in cranial morp... |
All the samples were collected from patients undergoing surgical ablation of larynx squamous cell carcinoma at the head and neck surgery division of the department of ophthalmology, otorhinolaryngology and head & neck of ribeirao preto medical school, usp (brazil). Inclusion criteria were: histopathological diagnosis o... |
The current recommendation for treatment of bilateral inguinal hernia is to repair both sides during the same surgery and anaesthetic procedure and to use the mesh on the transverse or pre - peritoneal fascia . Laparoscopic hernia repair became feasible after the incorporation of the principles of the technique describ... |
The advent of minimally invasive surgery has provided surgeons new techniques for treating clinical disease . Within the field of spinal surgery, techniques in lumbar interbody arthrodesis have shown a continued evolution of procedural approach and instrumentation . Minimally invasive spine surgery aims to reduce appro... |
The most recent network technologies are enabling a variety of new applications thanks to the provision of increased bandwidth and better management of quality of service . Nevertheless, telemedical services involving multimedia data are still lacking behind, due to the concern of the end users, that is, clinicians and... |
The case we present here is about a 22-year - old female patient referred to the department of conservative dentistry and endodontics with the chief complaint of pain in the left lower back tooth for the past 2 days . Her medical history was noncontributory and she gave a dental history of root canal treatment was done... |
Stabilizer muscles of the trunk in the human body refer to the deep muscles that contribute to stabilization . Stabilizer muscles in the waist region include the diaphragm, pelvic floor muscles, transversus abdominis, internal abdominal oblique, and multifidus1 . Among these stabilizer muscles, trunk stabilizer muscles... |
Metabolic encephalopathies are among one of the common causes of admission to hospital in the elderly age group . Depending on the severity and rate of development of hypercalcemia, patient can present with mild drowsiness to coma . In more than 90% of cases, hyperparathyroidism is the cause; however, in an emergency s... |
During the surgical removal of impacted lower third molar teeth, since the region is constricted and the visibility is insufficient and the position and bony structure of the teeth may be rigid, the patient is affected by trauma causing postoperative problems such as pain, edema, decreased function, and trismus . These... |
The practice of clinical laboratory medicine requires that test results be assessed to determine if the patient is normal or is subject to some pathological condition . Thus it s imperative that laboratories report test results along with reference intervals, in the past, typically called normal ranges . Establishing r... |
Symptomatic irreversible pulpitis is a pulpal state characterized by mild / severe pain that lingers after removal of a stimulus . In such cases, pulpectomy / extraction is required to alleviate the symptoms and prevent apical periodontitis . However, as the severity of pulpal inflammation cannot be measured quantitati... |
The child who chronically breathes through the mouth might also have difficulties with functional capacity, compromised respiratory system, damaging lung ventilation with lower thoracic expansibility and, consequently, may develop a weakness of the respiratory muscles.1 2 3 4 5 currently researchers and clinicians are ... |
As discussed by both citron and nerem and also bergman and nerem, the medical device industry evolved in the second half of the 20 century . First, there was kidney dialysis, a technology accredited to the pioneering work of a dutch physician, willem kolff . Beyond the treatment of chronic kidney failure, kolff's techn... |
He reported chronic non - productive cough, weakness for the preceding three weeks, loss of appetite, and weight loss of about ten kilograms in six months . The interview and the medical history documentation indicated that he was suffering from diabetes type 2, paroxysmal atrial fibrillation, hypertension, chronic ren... |
A total of 24 male sprague - dawley rats aged 10 weeks were obtained from a specific pathogen - free colony at samtako co. (osan, republic of korea) and used after one week of quarantine and acclimation . The institutional animal care and use committee of chonnam national university approved the protocols for the anima... |
This disease presents a slightly higher predominance in males, and most patients are diagnosed within the first fourth decades of life.1 although up to one third of dermoid cysts are found at birth, most of them are diagnosed in the second and third decades.2 almost 7% of all dermoids are located in the head and neck.3... |
Aquagenic syringeal acrokeratoderma (asa) is an acquired or hereditary keratoderma of unknown etiology . Drug - induced cases of asa of the palms have been reported, associated with rofecoxib, celecoxib, aspirin, and in one case, tobramycin used for cystic fibrosis . Several pathogenic mechanisms have been proposed, in... |
Scorpions are fascinating animals . Their venom with various potentialities has made them look both scary and fascinating . The venom of some species of scorpion has a remarkable impact on religious attitudes, concepts, and views of different societies in the east and west . Also, they are believed by a few traditional... |
Insulator proteins confer activity to insulators sequences, a class of functional elements with important roles in the regulation of chromosomal organization . In this study, we investigated the origin of the seven known proteins associated with insulator activity in d. melanogaster . To find potential orthologs of the... |
Antimicrobial resistance can also lead to a delay in the administration of appropriate drugs, and the drugs required to treat resistant pathogens can be toxic (2). Antimicrobial resistance has become a worldwide problem with the exception of a few countries in northern europe (3). However, even in sweden, where resista... |
The etiology of kienbock's disease, also known as (osteonecrosis of the lunate, remains controversial . It commonly occurs in patients twenty to fourty years old and presents with pain and stiffness in the dorsomedial aspect of the wrist . Several risk factors have been established to help explain its etiology: acute o... |
Pharmacopuncture refers to be in the limelight acupuncture therapy that treat diseases by using techniques such as warming (chunghwa), alcohol extraction or pressing to extract drugs from one or more oriental medicines and then injecting them into specific acupoints related to the disease and adjusting meridian functio... |
Stress may be broadly defined as the constellation of physiological and behavioral responses to any challenge that overwhelms, or is perceived to overwhelm, selective homeostatic systems of the individual (selye, 1980; day, 2005). A hallmark feature of stress entails activation of the hypothalamic - pituitary - adrenal... |
Type 2 diabetes mellitus (t2 dm) and obesity are increasingly assuming importance as public health problems in our country, especially among the north indians . Both conditions have a complex etiopathogenesis and epidemiology . It is well - known that across the globe indians are genetically and environmentally predisp... |
Enema administration has been a common practice worldwide for several centuries for the treatment of chronic constipation and for preparation of patient for a diagnostic test or a surgery . It seldom causes so prolonged lower gastrointestinal bleed that requires massive blood transfusion and rarely requires colectomy .... |
Attention - deficit / hyperactivity disorder (adhd) is a psychobiological disorder that is described by attention deficit, hyperactivity, and reduced impulse control . Based on the diagnostic and statistical manual of mental disorders, fifth edition (dsm - v), adhd is a persistent pattern of inattention and/or hyperact... |
Therapeutic proteins and peptides have potential to elicit immune responses [1, 2], resulting in anti - drug antibodies (adas) that can pose problems for both patient safety and product efficacy . Clinical consequences can range from relatively mild to serious adverse events [35], such as anaphylaxis, cytokine release ... |
They act via mechanisms classified as central or peripheral; though some act through both pathways . The antitussive effect of an ethanolic seed extract of picralima nitida (pne) has previously been established by the authors . However, the mode of activity of cough medicines could be attributed to at least five reason... |
Biliary cast syndrome (bcs) is characterized by the presence of casts within the intra- or extrahepatic biliary system . Retained lithogenic material in the bile duct may lead to obstruction of the biliary tract and also to cholangitis [1, 2]. Bcs is an uncommon complication which is mostly described in orthotopic live... |
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