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This paper is the report on and balance of some thirty years of transcultural research on mood disorders . The aim of our work was to produce a hypothesis bringing together the different ways in which discomfort manifests itself, with special emphasis on discomfort viewed through mood symptoms . Our goal was to see if ... |
Primary angiitis of the central nervous system (pacns) was identified as a distinct clinical entity in adults in 1959, and only recently now in children as a cause of childhood stroke . The disease should be suspected in children presenting with newly acquired neurological or psychiatric deficits after exclusion of cau... |
Over the last decades, health care systems have faced important challenges in dealing with pressures to increase the performance of the services they offer while the allocated resources to offer such care have remained stable or have decreased . Integration has been presented as an efficient solution to improve service... |
This study was conducted during 14 months (october 2014 to november 2015) on patients with ag (n=39) and gc (n=40) at two medical oncology and gastroenterology facilities in the northwestern region of algeria . Infection with h. pylori was confirmed by histopathology of biopsies sampled during diagnostic endoscopy (at ... |
, this definition probably not only applies to different symptoms and hence deserves further classification [1, 2] (for example, the distinction between spontaneous and provoked confabulations) but also appeals to a broader spectrum of disorders (psychosis, delirium, korsakoff disease, stroke) and to multiple brain und... |
Manual material handling (mmh) tasks are one of the common occupational factors (1). In most industries, and even in non - occupational settings, manual handling and lifting of weights happens very frequently; each of these tasks have their own specific requirements, and such tasks are one of the important reasons for ... |
During the seventeenth and eighteenth centuries, scurvy came to prominence as a disease of sailors and soldiers . There was general agreement that it was caused by putrefaction of the humours, the corruption of which was often attributed to a diet of noxious foods or prolonged exposure to cold and damp . By the late ei... |
Aggressive angiomyxoma (aa) is a rare benign soft tissue tumour usually affecting the pelvis and perineum of young women . Magnetic resonance imaging (mri) is crucial in the management of aa patients for its diagnostic contribution and for the preoperative assessment of the actual tumour extension . Given the current d... |
The syndrome often presents in late middle life; however, the incidence in the elderly has almost certainly been underestimated . In a recent pathologically ascertained series of 100 cases, the mean age of onset was 60.3 years with a range of 4079 years (hodges et al . The features of the language disturbance are captu... |
Breast cancer is a heterogeneous group of diseases which deviate from each other in natural history, morphology, molecular phenotype, clinical and radiological manifestations, and prognosis . Prognostic parameters are essential for predicting the outcome and response to therapy in individual cases . The long list of mo... |
Slx4 is a scaffold protein that binds to three dna repair endonucleases, mus81-eme1, xpf - ercc1, and slx1 (andersen et al ., 2009,, 2009, muoz et al ., 2009, saito et al ., 2009, the slx4 complex is required for the efficient repair of dna interstrand crosslinks (icls), (fekairi et al ., 2009, 2009), and the available... |
Crotoxin (ctx) is the main toxic component of the venom of the south american rattlesnake, crotalus durissus terrificus [1, 2]. The toxin is a heterodimeric complex consisting of basic and toxic phospholipase a2 and an acidic, nontoxic, and nonenzymatic component named crotapotin . In addition to its toxic properties, ... |
Postmortem dismemberment cases, sometimes referred to in the media as corpse mutilation, abuse of corpse or criminal dismemberment, present a challenge to investigators attempting to identify the tool used in the dismemberment . If multiple tools are recovered, examinations could be conducted to link or eliminate each ... |
Despite advancements in airway management, treatment of fractures in the maxillofacial region under general anesthesia remains a unique anesthetic challenge . We reviewed the pattern of airway management in patients with maxillofacial fractures and assessed those challenges associated with the different airway manageme... |
Certain colorectal conditions, such as ulcerative colitis and diffuse polyposis of the colon and rectum, and congenital intestinal abnormalities, such as total colonic aganglionosis, require a proctocolectomy and some type of intestinal restoration 1 . Although these procedures are technically demanding for surgeons, t... |
Children between 3 and 10 years of age with type 1 diabetes for at least 6 months and healthy controls subjects were recruited . All procedures were approved by the institutional review board and all parents or guardians signed informed consents . Children over 7 years of age signed assents (clinicaltrials.gov study nc... |
Diseases that were prevalent are now increasingly rare because of the widespread use of vaccines . Next to clean water, no single intervention has had such an overwhelming effect on reducing mortality from childhood diseases as the use of vaccines . The smallpox vaccine has eradicated a disease that had a 30% fatality ... |
Carcinoma of the prostate is the most common malignancy in men with increased incidence rates owing to the population ageing and the improvement of diagnostic procedures . The early detection of the bone metastases is of value in making decision regarding the treatment plan, which may vary extremely according to the bo... |
Actinomycosis, a rare chronic granulomatous infection induced by actinomyces species, colonizes the mouth, colon, and vagina (1). Mucosal disruption may lead to infection at virtually any anatomic site of immunocompromised body, such as head and neck, chest, abdomen, and pelvis region . In literature reports, about 50%... |
Muscle contraction is due to cyclic interactions between myosin ii motor proteins and actin filaments powered by the cellular fuel adenosine-5-triphosphate (atp). In in vitro assays one uses surface adsorbed myosin motors, or preferentially myosin motor fragments such as heavy meromyosin (hmm), to propel fluorescent ac... |
Poly(vinylidene fluoride) (pvdf) is a widely studied and used polymer, especially for industrial application due to its excellent chemical, mechanical, and uv stability properties . Pvdf membranes have been extensively used in ultrafiltration (uf) and microfiltration (mf) applications for separation processes and waste... |
The first - line regimen for the treatment of helicobacter pylori (h. pylori) infection in japan is triple therapy with a proton pump inhibitor (ppi), amoxicillin and clarithromycin [1, 2]. Failure of eradication of h. pylori infection with this first - line therapy has been reported in approximately 20% of infected pa... |
Diabetes mellitus (dm) is a popular lifelong metabolic disease, and probably will remain the most frequent cause of death in the following decades . Diabetes as a concerned epidemic problem is increasing all over the world. [210] statistical estimations show that the number of diabetic individuals will be 65% of the wo... |
Tissues are diverse not only in their structure and function but also in the dynamics of their constituent cells (leblond & walker, 1956). Sc turnover rates in adult mouse lineages vary by orders of magnitude (fig 1). Epithelial and male germ scs cycle rapidly, while in tissues such as liver, kidney and muscle, prolife... |
Diseases of the heart continue to be the leading cause of death in the united states [1, 2] and accounted for 24.6% of all deaths in 2009, down only 1.4% from 2006 despite several national campaigns and research strategies to reduce mortality [1, 2]. African americans have poorer health outcomes compared to their white... |
For efficacy studies, up to 3 female horses at a time were housed in single pens under bsl-4 conditions meeting the victorian bureau of animal welfare code of practice for the welfare of horses (www.dpi.vic.gov.au/agriculture/about-agriculture/legislation-regulation/animal-welfare-legislation/codes-of-practice-animal-w... |
In vivo studies using the animals provide invaluable information about various disease processes and help in development of treatment strategies . Virtually every medical achievement in the twentieth century relied on the use of animals in some way.1 the institute for laboratory animal research of the u.s . National ac... |
These tumors are rarely reported in infants . These lesions present as slowly progressive masses that can either compress to the adjacent vital structures or interfere with normal physiology . We report a case of giant, solitary nf presenting as a progressive mass in parotid region in an infant and review the relevant ... |
Advances in our understanding of the genetic alterations underlying clear cell renal cell carcinoma (rcc) has led to a proliferation of clinically active agents for this disease, and since 2005, a total of seven agents (sorafenib, sunitinib, temsirolimus, bevacizumab, everolimus, pazopanib, and axitinib) have been appr... |
Silver is a naturally occurring element with various physical properties, such as high thermal and electrical conductivity, ductility, hardness, malleability, and even antimicrobial ability . Silver was known and used by ancient people as early as 4000 bc, along with gold and copper.1 silver now has a wide variety of a... |
Schwannomas are infrequent tumors originating from the neural crest cells and usually interpreted as slow - growing benign nerve sheath tumors [1, 2]. Visceral sites of this tumor include the gastrointestinal tract, liver, pancreas, kidney, brain, heart and retroperitoneum . Retroperitoneal schwannomas account for only... |
Reports from the world health organization (who) reveal that 17.6 million persons contracted whooping cough in 2003 resulting in 279000 deaths; however, some authorities estimate the real figures of cases with pertussis to be around 50 million with 90% living in developing countries . According to the report of who reg... |
Pilar cysts are common, and benign lesions and malignant transformation in them is extremely rare . Trichilemmal cyst or pilar cyst is defined as a cyst containing keratin and its breakdown products . It is usually situated on the scalp with a wall resembling external hair root sheath . It is seen mainly in the at midd... |
Gastrointestinal stromal tumors (gists), which arise primarily in the gut wall, are most commonly mesenchymal neoplasms closely related to the interstitial cells of cajal . Gists typically carry gain - of - function mutations in genes encoding the kit receptor tyrosine kinase (cd117) or platelet - derived growth factor... |
For this cross - sectional study, we recruited men with type 2 diabetes (with and without cna), and attempted to age - match them with healthy control subjects . Inclusion criteria for the diabetic participants (with and without cna) included ambulatory men aged between 40 and 80 years with established type 2 diabetes ... |
Study area - blood and serum collections were carried out during four expeditions, three of which were conducted in the rainy season, while one was carried out in the dry season . Six riverside communities along the border of ac and am were studied: mapinguari (0924'08"s 6808'51.6"w) and andara (0917'29.8"s 06745'44.0"... |
It is a common tumor of male paratesticular tissues (epididymis, tunica or spermatic cord) and has also been described in females (uterus, fallopian tube, ovary and paraovarian tissues). The majority of these tumors are asymptomatic and presents as a mass in the genital area, which is worrisome to both patient and clin... |
Appalachia is a region of over 530,000 square kilometers in the eastern united states of america that roughly corresponds to the area surrounding the appalachian mountains . It is largely rural and has been geographically isolated in the past because of mountainous terrain, as well as transportation systems that have h... |
Further improvements in sequencing techniques have allowed sequences to be produced on a large scale and inserted into a computer . Appropriate programs, capable of processing data, have been developed to facilitate access and make all of the information available throughout the process (morozova and marra, 2008). Afte... |
The clinical implications of left axis deviation (lad) in patients with left bundle branch block (lbbb) have not been clearly elucidated . Some studies have reported that patients with lad do not have a significantly different prognosis compared with patients with a normal qrs axis,1)2)3) while others have shown that p... |
Rheumatoid arthritis (ra) and other connective tissue disorders are frequently associated with certain types of corneal or / and scleral pathology such as peripheral ulcerative keratitis, dry eye syndrome, and scleritis . It is also known that these conditions may lead to perforation of the eye by compromising the inte... |
Pushing the boundaries of surgical options in the curative treatment of hepatic malignancies has recently led to the development of a new surgical technique for patients in whom a conventional major liver resection (3 liver segments) is not feasible . The technique, known as alpps (associating liver partition and porta... |
This is an interesting case of a child who, following a minor head injury a few weeks earlier, was initially found to have a thin chronic subdural haematoma on plain computed tomography (ct) imaging . Following burr hole surgery for evacuation of the subdural haematoma his post - operative scan revealed an underlying a... |
Like other mammals, cattle possess a large amount of single nucleotide polymorphisms (snps) in their genome . The current ncbi dbsnp collection contains more than 2.2 million bovine snps (http://www.ncbi.nlm.nih.gov/projects/genome/guide/cow/). Among them, ~2.1 million snps were contributed by the baylor college of med... |
The purpose of this article is to report a case of central toxic keratopathy in a patient post transepithelial photorefractive keratectomy (transprk), followed immediately by corneal collagen cross - linking . This article describes the case of a 26-year - old male after bilateral aberration - free, transprk laser (sch... |
Reactive oxygen (ros) and nitrogen (nos) species (rons) normally regulate many of the intracellular signaling cascades that govern multiple cellular activities . However, when the amount of rons exceeds the cell s ability to metabolize / eliminate them, the cell becomes stressed and acquires genetic and epigenetic aber... |
Pulmonary embolismis a major global public health concern, with an estimated 900,000 venous thromboembolic events occurring annually in the united states alone . Massive pulmonary embolism in non - surgical patients is relatively common and presents a high degree of mortality (25 - 65%). The incidence of massive intra ... |
The capacity to produce antimicrobial peptides (amps) is widespread among gram - positive bacteria . These amps are directed against competitive microorganisms in order to generate a selective advantage for the producer organism . Class i consists of the so - called lantibiotics, which are posttranslationally modified ... |
Dental caries, periodontal disease, and opportunistic infections are among the common diseases of the oral cavity caused by the accumulation of pathogenic microorganisms, inappropriate nutritional habits, and improper oral hygiene [14]. Oral streptococci are the first isolated species to play a role in the formation of... |
Research from the last decades clearly shows that zinc has a vital role in neonatal development . Zinc is an essential trace element in humans and animals and is involved in countless metabolic and signaling pathways within the body . However, a particular role of zinc in the immune system and brain has been reported .... |
The deficiency of vitamin d3 is commonly associated with chronic kidney disease (ckd), and the prevalence of this hypovitaminosis increases as kidney function declines [1, 2]. Several factors, such as aging, loss of appetite, and other factors affecting cutaneous synthesis, such as low sun exposure and skin pigmentatio... |
The online version of this article (doi:10.1007/s00415 - 012 - 6498 - 2) contains supplementary material, which is available to authorized users . Patients with an acute basilar artery occlusion (bao) have a high risk of long - lasting disability and death [1, 2]. Although higher age, analyzed as a continuous variable,... |
Babesiosis is caused by a haemotropic protozoal parasite of the genus babesia, member of the phylum apicomplexa and transmitted by the bite of an infected tick (1). Babesiosis can occur without producing symptoms, but also be severe and sometimes fatal due to the intraerythrocytic parasite development (1). The disease ... |
Herpes simplex virus-1 (hsv-1) and hsv-2 which are dna viruses of alphaherpesvirinae subfamily and herpesviridae family, are the aetiological agent of hsv infections . These infections are among the infections most frequently encountered by humans, worldwide because humans are their only natural reservoirs, and no vect... |
Bile leaks can result from penetrating injury, such as gunshot (gsw) or knife wounds, or from blunt trauma, such as motor vehicle (mva) or motorcycle accidents (mca). The incidence of bile leaks following hepatobiliary trauma ranges from 0.5 to 21% depending on the criteria and methods used to diagnose the bile leak [1... |
Giant intracranial aneurysms have a lower propensity to bleed than small and medium - sized lesions and they may present with symptoms secondary to mass effect . While the diagnosis of a giant aneurysm can be readily made on radiology if there is any circulating component within the aneurysmal sac, establishing a pre -... |
Our ancestors knew that human beings, like plants, seeds, and other living things in the universe, were immersed in an evolutionary cycle . Thus, since the beginning of civilization, our ancestors have turned their gaze to the sky for answers and found that certain astronomical cycles overlap each other, just like the ... |
In recent years, advances in neuroimaging and surgical interventions have significantly decreased neurosurgical mortality and morbidity . However, postoperative central nervous system infection (pcnsi) remains one of the main reasons for poor prognosis in patients after neurosurgery . Interestingly, the american nation... |
Larsenico (as) un metalloide associato a diverse rocce, specialmente a minerali contenenti solfuro, rivelandosi molto mobile nellambiente: lerosione delle rocce converte infatti i solfuri di as in ossido arsenioso che entra nel ciclo ambientale contaminando i corpi idrici e, attraverso la catena alimentare, distribuend... |
Exposure of the esophagus to caustic material can lead to necrosis, ulceration, fibrosis, and ultimately stricture . Balloon and bougie dilation have similar efficacies for treating these strictures, although stricture recurrence after balloon dilation can occur in up to 30% of these cases . Furthermore, a long - term ... |
Familial hypobetalipoproteinemia (fhbl) is a rare autosomal co - dominant genetic disorder of lipid metabolism . It is characterized by serum low - density lipoprotein (ldl) cholesterol or apolipoprotein b (apob) levels 5th percentile . Apob is the largest of the apolipoproteins and is important in the formation and se... |
Airway inflammation and tissue remodeling that leads to peribronchial fibrosis are characteristic of copd, and contribute to the relentless progress of the disease.12 inhaled glucocorticoids are very effective anti - inflammatory agents in asthma, but have limited benefits in copd . Reduced expression of histone deacet... |
Specificity is one of the foundational components of training success . In sport performance training, one of the initial steps in the design of an exercise regimen is the identification of movements specific to the needs of the individual, which may include joint angles, and muscle actions and recruitment (1, 4). Move... |
In central and eastern european and central asian regions, countries report high rates of abortion, while at the same time displaying higher levels of secondary infertility (females with previous life births). Additionally, the prevalence of primary infertility (females with no previous life births) is significantly hi... |
Every year, more than 1 billion people are infected and more than 1 million die from vector - borne diseases . World health organization (who) has highlighted the serious and increasing threat of vector - borne diseases with the theme preventing vector - borne diseases and also with the slogan small bite, big threat fo... |
Quality of services is one of the most important factors for growth, success, and the presences of organizations, and it was considered as an effective and comprehensive strategy in order to improve their performances throughout the world (1, 2). In the health sector compared with other sectors, the quality of health s... |
Anaplastic thyroid cancer (atc) is one of the most aggressive tumors in human medicine . Therefore, the prognosis of atc patients is one of the worst among the malignant tumors in general . Despite multimodal treatment, which includes surgery, its annual incidence is about 2 per million residents and its share in the s... |
Low back pain (lbp) is a representative musculoskeletal disease with a current prevalence of 6090%; more than 80% people will experience lbp at least once in their lifetime . Lbp occurs when a poor lifestyle weakens the muscular strength of the waist and excessive loads on and tensions of the muscles create pain . Medi... |
Low - grade fibromyxoid sarcoma (lgfms) is a distinctive variant of fibrosarcoma, which was first described as a pathologic entity by evans in 1987 . Lgfms presents as a rare soft tissue tumor with a high metastasizing potential, despite the benign histologic appearance . These tumors usually occur in the lower extremi... |
Monocortical miniscrew - type temporary anchorage devices have been widely used to move a single tooth or segments of teeth.1,2 in addition, some studies have proposed simultaneous distalization of the entire dentition by applying force vector(s) from interradicular miniscrews to the main archwire.3 the underlying conc... |
Gestational diabetes mellitus (gdm) is a common medical complication of pregnancy defined as any degree of glucose intolerance with onset or first recognition during pregnancy [1, 2]. The initial criteria for diagnosis were established more than 40 years ago; however, these criteria did not necessarily identify pregnan... |
Neuregulin 1 (nrg1) is a ligand for the neu / erbb2 protooncogene and closely related to cell - cell signal interactions required for the growth and development of multiple organ systems . Nrg1 exerts its effect on the epithelium, cardiovascular system, and central nervous system (cns). In early embryogenesis, nrg1 is ... |
A total of 220 crc samples were obtained from patients who had undergone surgery between 2003 and 2004 at chonbuk national university hospital . We obtained clinical data from the patients' records, and survival data were collected in august 2011 . This study received a local ethics committee approval from the institut... |
The location and tissue characteristics on imaging studies are critical to narrow down the differential diagnosis of mediastinal masses . The most frequent lesions encountered in the mediastinum are thymoma, neurogenic tumours and benign cysts, altogether representing 60% of patients with mediastinal masses . Neurogeni... |
A core principle of both financial investment and biology is that diversity leads to strength . In biology, hybrid vigor produces healthy organisms, because each parental genome contributes complementary strengths and balances the other's weaknesses . In investing, diversity spreads risk, maximizing the chances of find... |
The second generation polyamidoamine (pamam) dendrimer with amidoethanol surface groups and ethylenediamine core was purchased from sigma - aldrich (poole, dorset, uk) and used without further purification . The metal salts: agno3, cucl22h2o, zncl2, feso4, and fecl3 were purchased from fisher scientific (loughborough, ... |
The content of the paper is the responsibility of the authors alone . Who may not necessarily agree . The content of the paper is the responsibility of the authors alone . Who may not necessarily agree. |
Hepatocellular carcinoma (hcc) is one of the most common malignancies and has a high mortality rate worldwide . Hcc usually develops in chronically damaged liver caused by an infection with the hepatitis b virus (hbv) or hepatitis c virus (hcv), alcoholic abuse and nonalcoholic fatty liver disease . Recent progress in ... |
Nurses routinely encounter by many stressful working conditions . A well - defined stress factor for nursing caregiver this clinical condition (agitation) is also an early symptom of the acute withdrawal syndrome, especially following inappropriate use of naltrexone in addicted people, which may jeopardize health statu... |
While the benefits of digital pathology in routine clinical use continue to inspire initiatives around the world, some european countries are arguably ahead of the curve . There are now a number of sites using digital pathology for primary diagnostic review, for example, in sweden, the netherlands, finland, lithuania, ... |
After ilizarov first reported successful distraction osteogenesis of the long bone, there was a report by mccarthy et al . (1) who were the first to perform a distraction osteogenesis of the human craniofacial mandible bone . Thereafter numerous studies reported on craniofacial bone expansion . In order to successfully... |
Myasthenia gravis (mg) is more commonly identified in younger individuals, especially women, and is usually associated with thymus disease . In these patients, however, elderly - onset mg has been also reported among patients 65 years of age.14 thymus abnormalities are usually rare among patients with late - onset mg, ... |
Enucleation was the standard treatment . In the early 1970s, radiotherapy and other treatment approaches, with the goal of preserving the eye, became increasingly popular . External beam irradiation using charged particles, such as protons may conserve a useful level of vision, depending on the size of the tumor and it... |
A high demand for presbyopia correction at the time of cataract surgery has increased the implantation of multifocal intraocular lenses (iols). Residual astigmatism is a concern with these lenses, because refractive astigmatism of 1.0 d or more can negatively impact visual outcomes with multifocal iols.1 this amount of... |
A common setup for image - guided neurosurgery uses a tracked pointer on a preoperative magnetic resonance imaging (mri) scan to visualize the tumor and its critical surroundings for guidance during the surgery . This neuronavigation assists in tumor localization and resection and is a common practice in developed coun... |
Biologics, which represent new developments in genetic engineering and biotechnology, include t - cell modulators as well as tumor necrosis factor (tnf)-alpha (tnf-) antagonists (eg, etanercept, infliximab, and adalimumab [humira (d2e7); abbott laboratories, abbott park, il, usa]). These bioengineered proteins target s... |
In spite of improvements in surveillance and clinical treatment strategies, the overall survival (os) of hepatocellular carcinoma (hcc) patients is unsatisfactory due to the high incidence of tumor recurrence and metastasis even after hepatectomy and lack of effective adjuvant therapy . Identification of reliable bioma... |
Thus, these teeth often may require the use of an intracanal post for retention of the core 57,25,26 . The post fits into a space created by the removal of a portion of filling material and this procedure may affect the quality of the apical seal6,7 . During mechanical preparation of the post space, the root canal fill... |
Annual influenza epidemics affect 1020% of the population resulting in substantial mortality and morbidity worldwide . The incidence of influenza in temperate areas of the northern and southern hemispheres is characterized by seasonal cycles with marked peaks in winter, hence, suggesting a role for climate . However, t... |
The children with idiopathic speech and language disorders are very heterogeneous by phenotype . The diagnosis of specific language impairment (sli) is generally made by applying exclusion and inclusion criteria according to icd 10 (1992). Sli is diagnosed, if the speech language development is significantly delayed, d... |
It is always difficult to write something new in a review, but is even more so when a topic has been as extensively covered over the last few years as the role of natriuretic peptides (nps) in the management of heart failure (hf). This review will present scientific evidence on nps, with a focus on n - terminal prohorm... |
Breast cancer is the most common cancer among us women and remains the number two cause of cancer death for us women . The recent figures and facts published in 2008 by the american cancer association indicate that 1 in 8 us women are at risk of developing breast cancer in a life time and that 1 in 35 us women are expe... |
The belief that natural medicines are much safer than synthetic drugs has caused exceptional growth in human exposure to natural products, as plants, phytotherapeutic agents, and phytopharmaceutical products . This fact has lead to a resurgence of scientific interest in their biological effects . In most countries ther... |
The beckwith wiedemann syndrome (bws, omim 130650) is a congenital overgrowth disorder associated with dysregulation of imprinted genes located at chromosome 11p15.5 . Children affected by bws show with variable expressivity several characteristic features, including macroglossia, gigantism, abdominal wall defects and ... |
Anti - mullerian hormone (amh), a polypeptide, secreted by the granulosa cells of the preantral and early developing antral follicles, has been shown to be a predictor of ovarian activity . Pcos patients show an increased number of antral follicles; therefore they have higher circulating amh levels than the healthy wom... |
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