query stringclasses 184
values | texts stringclasses 184
values | label float64 0 1 | metadata dict | query_id stringclasses 184
values | id stringlengths 7 7 ⌀ |
|---|---|---|---|---|---|
Aggravated inflammation is dependent on NLRP3 inflammasome activation.
Development of the acute and chronic inflammatory responses known as gout and pseudogout are associated with the deposition of monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals, respectively, in joints and periarticular tiss... | Aggravated inflammation is dependent on NLRP3 inflammasome activation.
Development of the acute and chronic inflammatory responses known as gout and pseudogout are associated with the deposition of monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals, respectively, in joints and periarticular tiss... | 1 | {
"query_id": "93",
"original_query_id": "93",
"context_doc_ids": [
"2692522"
],
"gold_doc_ids_in_context": [
"2692522"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.230180",
"dataset": "... | 93 | null |
ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.
Celiac disease is an immune-mediated disorder in which mucosal autoantibodies to the enzyme transglutaminase 2 (TG2) are generated in response to the exogenous antigen gluten in individuals who express human leukocyte antigen HLA-DQ2 or ... | ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.
Celiac disease is an immune-mediated disorder in which mucosal autoantibodies to the enzyme transglutaminase 2 (TG2) are generated in response to the exogenous antigen gluten in individuals who express human leukocyte antigen HLA-DQ2 or ... | 0 | {
"query_id": "1068",
"original_query_id": "1068",
"context_doc_ids": [
"6191684",
"19675911",
"27123743",
"2078658",
"1471041",
"13048272"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"ge... | 1068 | null |
PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.
Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult tissue macrophages originate during embryonic development and not... | PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.
Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult tissue macrophages originate during embryonic development and not... | 0.4 | {
"query_id": "969",
"original_query_id": "969",
"context_doc_ids": [
"22406695",
"17368516",
"25001628"
],
"gold_doc_ids_in_context": [
"17368516"
],
"total_gold_docs_for_query": 2,
"context_f1": 0.4,
"context_size": 3,
"generation_version": "1.0.0",
"generation_timestamp": "2025-... | 969 | null |
Perigenital skin is not the primary site of HIV acquisition.
To explore the mechanism by which herpes simplex virus (HSV)-2 infection is related to HIV-1 acquisition, we conducted in situ analysis of the cellular infiltrate from sequential biopsies of HSV-2 lesions from patients on and off antiviral therapy. CD4(+) an... | Perigenital skin is not the primary site of HIV acquisition.
To explore the mechanism by which herpes simplex virus (HSV)-2 infection is related to HIV-1 acquisition, we conducted in situ analysis of the cellular infiltrate from sequential biopsies of HSV-2 lesions from patients on and off antiviral therapy. CD4(+) an... | 1 | {
"query_id": "934",
"original_query_id": "934",
"context_doc_ids": [
"8563659"
],
"gold_doc_ids_in_context": [
"8563659"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.230493",
"dataset":... | 934 | null |
One in two surgical randomized controlled trials are discontinued early.
The cytosolic helicase retinoic acid-inducible gene-I (RIG-I) initiates immune responses to most RNA viruses by detecting viral 5'-triphosphorylated RNA (pppRNA). Although endogenous mRNA is also 5'-triphosphorylated, backbone modifications and t... | One in two surgical randomized controlled trials are discontinued early.
The cytosolic helicase retinoic acid-inducible gene-I (RIG-I) initiates immune responses to most RNA viruses by detecting viral 5'-triphosphorylated RNA (pppRNA). Although endogenous mRNA is also 5'-triphosphorylated, backbone modifications and t... | 0 | {
"query_id": "886",
"original_query_id": "886",
"context_doc_ids": [
"17150648",
"24221369",
"4455466",
"8148122",
"7370282",
"9889151"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"gener... | 886 | null |
Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.
Fatty acids are integral mediators of energy storage, membrane formation and cell signaling. The pathways that orchestrate uptake of fatty acids remain incompletely understood. Expression of the integrin ligand Mfge8 is increased in human o... | Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.
Fatty acids are integral mediators of energy storage, membrane formation and cell signaling. The pathways that orchestrate uptake of fatty acids remain incompletely understood. Expression of the integrin ligand Mfge8 is increased in human o... | 0.285714 | {
"query_id": "367",
"original_query_id": "367",
"context_doc_ids": [
"1686997",
"9505448",
"27099731",
"5389095",
"11360768",
"4394817"
],
"gold_doc_ids_in_context": [
"27099731"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.2857142857142857,
"context_size": 6,
"gen... | 367 | null |
Immune complex triggered cell death leads to extracellular release of nuclear DNA.
We compared conscious and nonconscious processing of briefly flashed words using a visual masking procedure while recording intracranial electroencephalogram (iEEG) in ten patients. Nonconscious processing of masked words was observed i... | Immune complex triggered cell death leads to extracellular release of nuclear DNA.
We compared conscious and nonconscious processing of briefly flashed words using a visual masking procedure while recording intracranial electroencephalogram (iEEG) in ten patients. Nonconscious processing of masked words was observed i... | 0 | {
"query_id": "555",
"original_query_id": "555",
"context_doc_ids": [
"13901073",
"17930286",
"1797622",
"1710116",
"33257464",
"23349986"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"gen... | 555 | null |
The risk of female prisoners harming themselves is ten times that of male prisoners.
BACKGROUND Self-harm and suicide are common in prisoners, yet robust information on the full extent and characteristics of people at risk of self-harm is scant. Furthermore, understanding how frequently self-harm is followed by suicid... | The risk of female prisoners harming themselves is ten times that of male prisoners.
BACKGROUND Self-harm and suicide are common in prisoners, yet robust information on the full extent and characteristics of people at risk of self-harm is scant. Furthermore, understanding how frequently self-harm is followed by suicid... | 1 | {
"query_id": "1269",
"original_query_id": "1269",
"context_doc_ids": [
"13900610"
],
"gold_doc_ids_in_context": [
"13900610"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.230826",
"datas... | 1269 | null |
The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.
The oncogenic BCR/ABL tyrosine kinase induces constitutive DNA damage in Philadelphia chromosome (Ph)-positive leukemia cells. We find that BCR/ABL-induced reactive oxygen species (ROSs) cause chroni... | The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.
The oncogenic BCR/ABL tyrosine kinase induces constitutive DNA damage in Philadelphia chromosome (Ph)-positive leukemia cells. We find that BCR/ABL-induced reactive oxygen species (ROSs) cause chroni... | 0.333333 | {
"query_id": "1206",
"original_query_id": "1206",
"context_doc_ids": [
"4687948",
"3898784",
"13023410",
"19736671",
"18909530"
],
"gold_doc_ids_in_context": [
"18909530"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.33333333333333337,
"context_size": 5,
"generation_ver... | 1206 | null |
PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.
Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1-independent thermogenic mechanism in beige fat that invo... | PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.
Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1-independent thermogenic mechanism in beige fat that invo... | 0.333333 | {
"query_id": "916",
"original_query_id": "916",
"context_doc_ids": [
"1410197",
"19205437",
"11603066",
"18037805",
"15488881"
],
"gold_doc_ids_in_context": [
"18037805"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.33333333333333337,
"context_size": 5,
"generation_vers... | 916 | null |
Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.
Chronic feeding on high-calorie diets causes obesity and type 2 diabetes mellitus (T2DM), illnesses that affect hundreds of millions. Thus, understanding the pathways protecting against diet-induced metabolic i... | Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.
Chronic feeding on high-calorie diets causes obesity and type 2 diabetes mellitus (T2DM), illnesses that affect hundreds of millions. Thus, understanding the pathways protecting against diet-induced metabolic i... | 0.333333 | {
"query_id": "126",
"original_query_id": "126",
"context_doc_ids": [
"10582939",
"13001323",
"11291348",
"24512064",
"5956380"
],
"gold_doc_ids_in_context": [
"24512064"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.33333333333333337,
"context_size": 5,
"generation_vers... | 126 | null |
Whole brain radiotherapy increases the occurrence of new brain metastases.
OBJECTIVE Folate and vitamin B12 are two vital regulators in the metabolic process of homocysteine, which is a risk factor of atherothrombotic events. Low folate intake or low plasma folate concentration is associated with increased stroke risk... | Whole brain radiotherapy increases the occurrence of new brain metastases.
OBJECTIVE Folate and vitamin B12 are two vital regulators in the metabolic process of homocysteine, which is a risk factor of atherothrombotic events. Low folate intake or low plasma folate concentration is associated with increased stroke risk... | 0.4 | {
"query_id": "1376",
"original_query_id": "1376",
"context_doc_ids": [
"3944632",
"37424881",
"21003930",
"14682243"
],
"gold_doc_ids_in_context": [
"3944632"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.4,
"context_size": 4,
"generation_version": "1.0.0",
"generation_ti... | 1376 | null |
Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.
Non-coding RNAs have emerged as crucial regulators of gene expression and cell fate decisions. However, their expression patterns and regulatory functions during normal and maligna... | Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.
Non-coding RNAs have emerged as crucial regulators of gene expression and cell fate decisions. However, their expression patterns and regulatory functions during normal and maligna... | 0 | {
"query_id": "1106",
"original_query_id": "1106",
"context_doc_ids": [
"4883040",
"4469125",
"26283293",
"4350400",
"1974176",
"3321943"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"gene... | 1106 | null |
NR5A2 does not play a role in development of endometrial tissues.
Activation of self-reactive T cells and their trafficking to target tissues leads to autoimmune organ destruction. Mice lacking the co-inhibitory receptor cytotoxic T lymphocyte antigen-4 (CTLA-4) develop fatal autoimmunity characterized by lymphocytic ... | NR5A2 does not play a role in development of endometrial tissues.
Activation of self-reactive T cells and their trafficking to target tissues leads to autoimmune organ destruction. Mice lacking the co-inhibitory receptor cytotoxic T lymphocyte antigen-4 (CTLA-4) develop fatal autoimmunity characterized by lymphocytic ... | 0 | {
"query_id": "835",
"original_query_id": "835",
"context_doc_ids": [
"22703082",
"2052720",
"38380061",
"7209559",
"2462673",
"57574395"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"gene... | 835 | null |
Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility.
CONTEXT Chronic tension-type headaches are characterized by near-daily headaches and often are difficult to manage in primary practice. Behavioral and pharmacological therapies each appear modestly effec... | Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility.
CONTEXT Chronic tension-type headaches are characterized by near-daily headaches and often are difficult to manage in primary practice. Behavioral and pharmacological therapies each appear modestly effec... | 0 | {
"query_id": "1325",
"original_query_id": "1325",
"context_doc_ids": [
"6191684",
"10582939",
"5114282",
"44048701",
"2033917",
"18949516"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"ge... | 1325 | null |
Polymeal nutrition increases cardiovascular mortality.
Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes. Wolfram syndrome 1 (WFS1) has been shown to be an important regulator of the ER stress signalling pathway; however, its ro... | Polymeal nutrition increases cardiovascular mortality.
Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes. Wolfram syndrome 1 (WFS1) has been shown to be an important regulator of the ER stress signalling pathway; however, its ro... | 0.4 | {
"query_id": "959",
"original_query_id": "959",
"context_doc_ids": [
"1522647",
"32587939",
"17123657",
"8780599"
],
"gold_doc_ids_in_context": [
"8780599"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.4,
"context_size": 4,
"generation_version": "1.0.0",
"generation_times... | 959 | null |
Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.
Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controversial results owing to the use of unreliable methods for clearly identifyin... | Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.
Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controversial results owing to the use of unreliable methods for clearly identifyin... | 1 | {
"query_id": "689",
"original_query_id": "689",
"context_doc_ids": [
"22080671"
],
"gold_doc_ids_in_context": [
"22080671"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.231529",
"dataset... | 689 | null |
ART has no effect on the infectiveness of HIV-positive people.
Amitriptyline is the medication of first choice in the treatment of chronic tension-type headache. In 197 patients with chronic tension-type headache (87M and 110F with a mean age of 38 +/- 13 (18-68)) efficacy and tolerability of 60-90 mg amitriptylinoxid... | ART has no effect on the infectiveness of HIV-positive people.
Amitriptyline is the medication of first choice in the treatment of chronic tension-type headache. In 197 patients with chronic tension-type headache (87M and 110F with a mean age of 38 +/- 13 (18-68)) efficacy and tolerability of 60-90 mg amitriptylinoxid... | 0 | {
"query_id": "60",
"original_query_id": "60",
"context_doc_ids": [
"2692522",
"4427392",
"2565138",
"23865182",
"3701541",
"19313533"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 2,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"generat... | 60 | null |
Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.
Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N... | Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.
Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N... | 1 | {
"query_id": "523",
"original_query_id": "523",
"context_doc_ids": [
"14803797"
],
"gold_doc_ids_in_context": [
"14803797"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.231662",
"dataset... | 523 | null |
Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.
IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. OBJECTIVE To determine efficacy and safety of varenicline ... | Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.
IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. OBJECTIVE To determine efficacy and safety of varenicline ... | 0.5 | {
"query_id": "272",
"original_query_id": "272",
"context_doc_ids": [
"13400643",
"11614737",
"39264456"
],
"gold_doc_ids_in_context": [
"11614737"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.5,
"context_size": 3,
"generation_version": "1.0.0",
"generation_timestamp": "2025-... | 272 | null |
Bariatric surgery reduces postmenopausal breast cancer.
Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease. LRRK2 is a multifunctional protein affecting many cellular processes and has been described to bind microtubules. Defective microtubule-based axonal transport... | Bariatric surgery reduces postmenopausal breast cancer.
Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease. LRRK2 is a multifunctional protein affecting many cellular processes and has been described to bind microtubules. Defective microtubule-based axonal transport... | 0.333333 | {
"query_id": "169",
"original_query_id": "169",
"context_doc_ids": [
"10009203",
"9638032",
"4373433",
"5824985",
"12643937"
],
"gold_doc_ids_in_context": [
"5824985"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.33333333333333337,
"context_size": 5,
"generation_version... | 169 | null |
Insulin effects appetite via ventral tegmental neurons.
Dopaminergic midbrain neurons integrate signals on food palatability and food-associated reward into the complex control of energy homeostasis. To define the role of insulin receptor (IR) signaling in this circuitry, we inactivated IR signaling in tyrosine hydrox... | Insulin effects appetite via ventral tegmental neurons.
Dopaminergic midbrain neurons integrate signals on food palatability and food-associated reward into the complex control of energy homeostasis. To define the role of insulin receptor (IR) signaling in this circuitry, we inactivated IR signaling in tyrosine hydrox... | 1 | {
"query_id": "643",
"original_query_id": "643",
"context_doc_ids": [
"15535511"
],
"gold_doc_ids_in_context": [
"15535511"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.231825",
"dataset... | 643 | null |
Lack of FGF21 in mice increases life expectancy.
Interleukin-18 (IL18) participates in atherogenesis through several putative mechanisms. Interruption of IL18 action reduces atherosclerosis in mice. Here, we show that absence of the IL18 receptor (IL18r) does not affect atherosclerosis in apolipoprotein E–deficient (A... | Lack of FGF21 in mice increases life expectancy.
Interleukin-18 (IL18) participates in atherogenesis through several putative mechanisms. Interruption of IL18 action reduces atherosclerosis in mice. Here, we show that absence of the IL18 receptor (IL18r) does not affect atherosclerosis in apolipoprotein E–deficient (A... | 0.4 | {
"query_id": "680",
"original_query_id": "680",
"context_doc_ids": [
"24384587",
"9505448",
"22406695",
"9315213"
],
"gold_doc_ids_in_context": [
"9315213"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.4,
"context_size": 4,
"generation_version": "1.0.0",
"generation_times... | 680 | null |
Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.
BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urba... | Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.
BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urba... | 1 | {
"query_id": "337",
"original_query_id": "337",
"context_doc_ids": [
"2097256"
],
"gold_doc_ids_in_context": [
"2097256"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.231908",
"dataset":... | 337 | null |
Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.
The Global HIV Vaccine Enterprise convened a two-day workshop in May of 2007 to discuss humoral immune responses to HIV and approaches to design vaccines that induce viral neutralizing and other potentially protective antibody responses... | Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.
The Global HIV Vaccine Enterprise convened a two-day workshop in May of 2007 to discuss humoral immune responses to HIV and approaches to design vaccines that induce viral neutralizing and other potentially protective antibody responses... | 1 | {
"query_id": "398",
"original_query_id": "398",
"context_doc_ids": [
"8883846"
],
"gold_doc_ids_in_context": [
"8883846"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.231930",
"dataset":... | 398 | null |
Integrated care is successful at tackling multiple comorbidities.
OBJECTIVE To evaluate the effectiveness of integrated care for chronic physical diseases and depression in reducing disability and improving quality of life. DESIGN A randomised controlled trial of multi-condition collaborative care for depression and p... | Integrated care is successful at tackling multiple comorbidities.
OBJECTIVE To evaluate the effectiveness of integrated care for chronic physical diseases and depression in reducing disability and improving quality of life. DESIGN A randomised controlled trial of multi-condition collaborative care for depression and p... | 1 | {
"query_id": "648",
"original_query_id": "648",
"context_doc_ids": [
"15041758"
],
"gold_doc_ids_in_context": [
"15041758"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.231973",
"dataset... | 648 | null |
Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments
CONTEXT Some studies have inferred that an epidemic of Kaposi sarcoma-associated herpesvirus (KSHV) infection in homosexual men in the United States occurred concurrently with that of human immunodeficiency virus (HIV), but there have bee... | Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments
CONTEXT Some studies have inferred that an epidemic of Kaposi sarcoma-associated herpesvirus (KSHV) infection in homosexual men in the United States occurred concurrently with that of human immunodeficiency virus (HIV), but there have bee... | 0 | {
"query_id": "224",
"original_query_id": "224",
"context_doc_ids": [
"470625",
"418246",
"16855829",
"5691302",
"5548081",
"3321943"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"generati... | 224 | null |
ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.
Haploid cells are amenable for genetic analysis. Recent success in the derivation of mouse haploid embryonic stem cells (haESCs) via parthenogenesis has enabled genetic screening in mammalian cells. However, successful generation of... | ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.
Haploid cells are amenable for genetic analysis. Recent success in the derivation of mouse haploid embryonic stem cells (haESCs) via parthenogenesis has enabled genetic screening in mammalian cells. However, successful generation of... | 0.4 | {
"query_id": "52",
"original_query_id": "52",
"context_doc_ids": [
"14340571",
"45638119",
"26996935",
"13513790"
],
"gold_doc_ids_in_context": [
"45638119"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.4,
"context_size": 4,
"generation_version": "1.0.0",
"generation_time... | 52 | null |
The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.
Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cellular level of the disease are currently not available. H... | The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.
Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cellular level of the disease are currently not available. H... | 0.333333 | {
"query_id": "1215",
"original_query_id": "1215",
"context_doc_ids": [
"37424881",
"16355392",
"9505448",
"40096222",
"18872233"
],
"gold_doc_ids_in_context": [
"16355392"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.33333333333333337,
"context_size": 5,
"generation_ve... | 1215 | null |
Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.
Age-related changes in the niche have long been postulated to impair the function of somatic stem cells. Here we demonstrate that the aged stem cell niche in skeletal muscle contains substantially reduced levels of fibronectin (FN),... | Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.
Age-related changes in the niche have long been postulated to impair the function of somatic stem cells. Here we demonstrate that the aged stem cell niche in skeletal muscle contains substantially reduced levels of fibronectin (FN),... | 0.5 | {
"query_id": "606",
"original_query_id": "606",
"context_doc_ids": [
"19912367",
"9988425",
"712078"
],
"gold_doc_ids_in_context": [
"712078"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.5,
"context_size": 3,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24... | 606 | null |
General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.
OBJECTIVE To measure whether the benefits of a single education and self management structured programme for people with newly diagnosed type 2 diabetes mellitus are sustained at three... | General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.
OBJECTIVE To measure whether the benefits of a single education and self management structured programme for people with newly diagnosed type 2 diabetes mellitus are sustained at three... | 0.4 | {
"query_id": "454",
"original_query_id": "454",
"context_doc_ids": [
"2095573",
"12584053",
"4200695",
"21498497"
],
"gold_doc_ids_in_context": [
"4200695"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.4,
"context_size": 4,
"generation_version": "1.0.0",
"generation_times... | 454 | null |
Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.
Embryonic stem cells have the ability to remain undifferentiated and proliferate indefinitely in vitro while maintaining the potential to differentiate into derivatives of all three embryonic germ layers. These cells have, therefore, potential for in ... | Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.
Embryonic stem cells have the ability to remain undifferentiated and proliferate indefinitely in vitro while maintaining the potential to differentiate into derivatives of all three embryonic germ layers. These cells have, therefore, potential for in ... | 0.4 | {
"query_id": "1027",
"original_query_id": "1027",
"context_doc_ids": [
"18956141",
"36651210",
"3113630",
"13868795"
],
"gold_doc_ids_in_context": [
"3113630"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.4,
"context_size": 4,
"generation_version": "1.0.0",
"generation_ti... | 1027 | null |
Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.
In this study, we used whole-genome sequencing and gene expression profiling of 215 human induced pluripotent stem cell (iPSC) lines from different donors to identify genetic variants associated with RNA expression for 5,746 gen... | Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.
In this study, we used whole-genome sequencing and gene expression profiling of 215 human induced pluripotent stem cell (iPSC) lines from different donors to identify genetic variants associated with RNA expression for 5,746 gen... | 0 | {
"query_id": "123",
"original_query_id": "123",
"context_doc_ids": [
"4632921",
"49556906",
"5099266",
"1456068",
"3701541",
"1148122"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"genera... | 123 | null |
Microcin J25 inhibits nucleoside triphosphate (NTP) binding.
IMPORTANCE Understanding the major health problems in the United States and how they are changing over time is critical for informing national health policy. OBJECTIVES To measure the burden of diseases, injuries, and leading risk factors in the United State... | Microcin J25 inhibits nucleoside triphosphate (NTP) binding.
IMPORTANCE Understanding the major health problems in the United States and how they are changing over time is critical for informing national health policy. OBJECTIVES To measure the burden of diseases, injuries, and leading risk factors in the United State... | 0 | {
"query_id": "788",
"original_query_id": "788",
"context_doc_ids": [
"20418809",
"43329366",
"2052720",
"8582337",
"23078022",
"13513790"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"gen... | 788 | null |
Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.
Animal host defense against infection requires the expression of defense genes at the right place and the right time. Understanding such tight control of host defense requires the elucidation... | Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.
Animal host defense against infection requires the expression of defense genes at the right place and the right time. Understanding such tight control of host defense requires the elucidation... | 0.5 | {
"query_id": "1312",
"original_query_id": "1312",
"context_doc_ids": [
"5548081",
"6493422",
"24177706"
],
"gold_doc_ids_in_context": [
"24177706"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.5,
"context_size": 3,
"generation_version": "1.0.0",
"generation_timestamp": "2025-... | 1312 | null |
Walking in traffic areas in London improves lung function in elderly adults.
T cell activation is predicated on the interaction between the T cell receptor and peptide-major histocompatibility (pMHC) ligands. The factors that determine the stimulatory potency of a pMHC molecule remain unclear. We describe results show... | Walking in traffic areas in London improves lung function in elderly adults.
T cell activation is predicated on the interaction between the T cell receptor and peptide-major histocompatibility (pMHC) ligands. The factors that determine the stimulatory potency of a pMHC molecule remain unclear. We describe results show... | 0 | {
"query_id": "1373",
"original_query_id": "1373",
"context_doc_ids": [
"14706752",
"21993510",
"2000038",
"4740447",
"13868795",
"306006"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"gen... | 1373 | null |
The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.
The functional heart is comprised of distinct mesoderm-derived lineages including cardiomyocytes, endothelial cells and vascular smooth muscle cells. Studies in the mouse embryo and the mouse embryonic stem cell ... | The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.
The functional heart is comprised of distinct mesoderm-derived lineages including cardiomyocytes, endothelial cells and vascular smooth muscle cells. Studies in the mouse embryo and the mouse embryonic stem cell ... | 1 | {
"query_id": "1239",
"original_query_id": "1239",
"context_doc_ids": [
"21387297",
"4427392"
],
"gold_doc_ids_in_context": [
"21387297",
"4427392"
],
"total_gold_docs_for_query": 2,
"context_f1": 1,
"context_size": 2,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07... | 1239 | null |
NAC inhibits the generation of angiotensin-converting enzyme.
CONTEXT The growth inhibitory effect of tamoxifen, which is used for the treatment of hormone receptor-positive breast cancer, is mediated by its metabolites, 4-hydroxytamoxifen and endoxifen. The formation of active metabolites is catalyzed by the polymorp... | NAC inhibits the generation of angiotensin-converting enzyme.
CONTEXT The growth inhibitory effect of tamoxifen, which is used for the treatment of hormone receptor-positive breast cancer, is mediated by its metabolites, 4-hydroxytamoxifen and endoxifen. The formation of active metabolites is catalyzed by the polymorp... | 0.333333 | {
"query_id": "828",
"original_query_id": "828",
"context_doc_ids": [
"27873158",
"24341590",
"13578199",
"4678846",
"32275758"
],
"gold_doc_ids_in_context": [
"4678846"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.33333333333333337,
"context_size": 5,
"generation_versi... | 828 | null |
Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.
Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cellular level of the disease are currently not availab... | Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.
Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cellular level of the disease are currently not availab... | 1 | {
"query_id": "626",
"original_query_id": "626",
"context_doc_ids": [
"16355392"
],
"gold_doc_ids_in_context": [
"16355392"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.232799",
"dataset... | 626 | null |
Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.
OBJECTIVE To assess the performance and impact of primary human papillomavirus (HPV) DNA screening with cytology triage compared with conventional cytology on cervical cancer and severe pre-cancerous lesions. DESIGN Randomised tr... | Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.
OBJECTIVE To assess the performance and impact of primary human papillomavirus (HPV) DNA screening with cytology triage compared with conventional cytology on cervical cancer and severe pre-cancerous lesions. DESIGN Randomised tr... | 0.5 | {
"query_id": "413",
"original_query_id": "413",
"context_doc_ids": [
"27446873",
"6309659",
"13899137"
],
"gold_doc_ids_in_context": [
"6309659"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.5,
"context_size": 3,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07... | 413 | null |
Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.
BACKGROUND Patients with familial amyloid polyneuropathy, a rare hereditary form of amyloidosis, have progressive autonomic neuropathy. The disease usually does not induce heart failure but is associated with sud... | Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.
BACKGROUND Patients with familial amyloid polyneuropathy, a rare hereditary form of amyloidosis, have progressive autonomic neuropathy. The disease usually does not induce heart failure but is associated with sud... | 1 | {
"query_id": "1112",
"original_query_id": "1112",
"context_doc_ids": [
"1686881"
],
"gold_doc_ids_in_context": [
"1686881"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.232891",
"dataset... | 1112 | null |
Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.
Subdividing proliferating tissues into compartments is an evolutionarily conserved strategy of animal development [1-6]. Signals across boundaries between compartments can result in local expression of secreted proteins orga... | Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.
Subdividing proliferating tissues into compartments is an evolutionarily conserved strategy of animal development [1-6]. Signals across boundaries between compartments can result in local expression of secreted proteins orga... | 1 | {
"query_id": "355",
"original_query_id": "355",
"context_doc_ids": [
"12800122",
"38380061"
],
"gold_doc_ids_in_context": [
"12800122",
"38380061"
],
"total_gold_docs_for_query": 2,
"context_f1": 1,
"context_size": 2,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07... | 355 | null |
RUNX is not expressed in skin tissue.
BACKGROUND Screening for cervical cancer based on testing for human papillomavirus (HPV) increases the sensitivity of detection of high-grade (grade 2 or 3) cervical intraepithelial neoplasia, but whether this gain represents overdiagnosis or protection against future high-grade c... | RUNX is not expressed in skin tissue.
BACKGROUND Screening for cervical cancer based on testing for human papillomavirus (HPV) increases the sensitivity of detection of high-grade (grade 2 or 3) cervical intraepithelial neoplasia, but whether this gain represents overdiagnosis or protection against future high-grade c... | 0 | {
"query_id": "1008",
"original_query_id": "1008",
"context_doc_ids": [
"9638032",
"46695481",
"16927286",
"9500590",
"857189",
"13910150"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"gen... | 1008 | null |
Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.
The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein antigens (ACPAs) i... | Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.
The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein antigens (ACPAs) i... | 0.5 | {
"query_id": "264",
"original_query_id": "264",
"context_doc_ids": [
"24384587",
"3874000",
"11328820"
],
"gold_doc_ids_in_context": [
"11328820"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.5,
"context_size": 3,
"generation_version": "1.0.0",
"generation_timestamp": "2025-0... | 264 | null |
In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.
BACKGROUND Although cigarette smoking, excessive alcohol drinking, obesity, and several other well-studied unhealthy lifestyle-related factors each have been linked to the risk of multiple chronic diseases and premat... | In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.
BACKGROUND Although cigarette smoking, excessive alcohol drinking, obesity, and several other well-studied unhealthy lifestyle-related factors each have been linked to the risk of multiple chronic diseases and premat... | 0 | {
"query_id": "565",
"original_query_id": "565",
"context_doc_ids": [
"13400643",
"2890952",
"1456068",
"5289038",
"7185591",
"4394817"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"genera... | 565 | null |
FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).
The Sir2 deacetylase modulates organismal life-span in various species. However, the molecular mechanisms by which Sir2 increases longevity are largely unknown. We show that in mammalian cells, the Sir2 homolog SIRT1 appears to control ... | FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).
The Sir2 deacetylase modulates organismal life-span in various species. However, the molecular mechanisms by which Sir2 increases longevity are largely unknown. We show that in mammalian cells, the Sir2 homolog SIRT1 appears to control ... | 1 | {
"query_id": "430",
"original_query_id": "430",
"context_doc_ids": [
"28937856"
],
"gold_doc_ids_in_context": [
"28937856"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.233166",
"dataset... | 430 | null |
Notch signaling occurs between tumor cells and stromal cells.
OBJECTIVE To assess the performance and impact of primary human papillomavirus (HPV) DNA screening with cytology triage compared with conventional cytology on cervical cancer and severe pre-cancerous lesions. DESIGN Randomised trial. SETTING Population base... | Notch signaling occurs between tumor cells and stromal cells.
OBJECTIVE To assess the performance and impact of primary human papillomavirus (HPV) DNA screening with cytology triage compared with conventional cytology on cervical cancer and severe pre-cancerous lesions. DESIGN Randomised trial. SETTING Population base... | 0 | {
"query_id": "863",
"original_query_id": "863",
"context_doc_ids": [
"1686997",
"24221369",
"18816720",
"27446873",
"1982286",
"8563659"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 2,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"gene... | 863 | null |
A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.
Blind individuals often demonstrate enhanced nonvisual perceptual abilities. However, the neural substrate that underlies this improved performance remains to be fully understood. An earlier behavioral study demonstrat... | A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.
Blind individuals often demonstrate enhanced nonvisual perceptual abilities. However, the neural substrate that underlies this improved performance remains to be fully understood. An earlier behavioral study demonstrat... | 0 | {
"query_id": "46",
"original_query_id": "46",
"context_doc_ids": [
"18174210",
"11328820",
"9167230",
"19799455",
"313394",
"3113630"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"generat... | 46 | null |
Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.
Calorie restriction slows aging and increases life span in many organisms. In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2. Here we report the... | Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.
Calorie restriction slows aging and increases life span in many organisms. In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2. Here we report the... | 0 | {
"query_id": "112",
"original_query_id": "112",
"context_doc_ids": [
"22180793",
"17930286",
"2014909",
"7185591",
"5304891",
"3321943"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"gener... | 112 | null |
Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.
During fasting, mammals maintain normal glucose homeostasis by stimulating hepatic gluconeogenesis. Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic glucone... | Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.
During fasting, mammals maintain normal glucose homeostasis by stimulating hepatic gluconeogenesis. Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic glucone... | 1 | {
"query_id": "1045",
"original_query_id": "1045",
"context_doc_ids": [
"22500262"
],
"gold_doc_ids_in_context": [
"22500262"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.233435",
"datas... | 1045 | null |
Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.
Experience gained from the Global Malaria Eradication Program (1955-72) identified a set of shared technical and operational factors that enabled some countries to successfully eliminate malaria. Spatial data for these... | Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.
Experience gained from the Global Malaria Eradication Program (1955-72) identified a set of shared technical and operational factors that enabled some countries to successfully eliminate malaria. Spatial data for these... | 0 | {
"query_id": "896",
"original_query_id": "896",
"context_doc_ids": [
"1173667",
"1710116",
"32275758",
"16999023",
"18949516",
"306006"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"gener... | 896 | null |
Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.
Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with recipro... | Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.
Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with recipro... | 0.4 | {
"query_id": "1330",
"original_query_id": "1330",
"context_doc_ids": [
"14075252",
"16322674",
"14332945",
"32275758"
],
"gold_doc_ids_in_context": [
"14075252"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.4,
"context_size": 4,
"generation_version": "1.0.0",
"generation_... | 1330 | null |
In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.
The role of ataxia telangiectasia mutated (ATM), a DNA double-strand break recognition and response protein, in inflammation and inflammatory diseases is unclear. We have previously... | In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.
The role of ataxia telangiectasia mutated (ATM), a DNA double-strand break recognition and response protein, in inflammation and inflammatory diseases is unclear. We have previously... | 0 | {
"query_id": "584",
"original_query_id": "584",
"context_doc_ids": [
"11527199",
"5572127",
"4394817",
"8563659",
"19313533",
"16728949"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"gene... | 584 | null |
Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.
The interest in brown adipose tissue (BAT) as a target to combat metabolic disease has recently been renewed with the discovery of functional BAT in humans. In rodents, BAT can be activated by bile acids, which... | Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.
The interest in brown adipose tissue (BAT) as a target to combat metabolic disease has recently been renewed with the discovery of functional BAT in humans. In rodents, BAT can be activated by bile acids, which... | 0.285714 | {
"query_id": "1040",
"original_query_id": "1040",
"context_doc_ids": [
"10991183",
"13639330",
"16626264",
"13027590",
"1568684"
],
"gold_doc_ids_in_context": [
"16626264"
],
"total_gold_docs_for_query": 2,
"context_f1": 0.28571428571428575,
"context_size": 5,
"generation_ve... | 1040 | null |
KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.
Survivors of pediatric Hodgkin's lymphoma are at risk for radiation therapy–induced second malignant neoplasms (SMNs). We identified two variants at chromosome 6q21 associated with SMNs in survivors of Hodgkin's lymphoma treate... | KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.
Survivors of pediatric Hodgkin's lymphoma are at risk for radiation therapy–induced second malignant neoplasms (SMNs). We identified two variants at chromosome 6q21 associated with SMNs in survivors of Hodgkin's lymphoma treate... | 0 | {
"query_id": "665",
"original_query_id": "665",
"context_doc_ids": [
"25001628",
"33409100",
"1649738",
"7370282",
"313394",
"14797520"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"gener... | 665 | null |
MeCP2 influences the synaptic maturation of neurons.
BACKGROUND Although unstable coronary artery disease is the most common reason for admission to a coronary care unit, the long-term prognosis of patients with this diagnosis is unknown. This is particularly true for patients with diabetes mellitus, who are known to ... | MeCP2 influences the synaptic maturation of neurons.
BACKGROUND Although unstable coronary artery disease is the most common reason for admission to a coronary care unit, the long-term prognosis of patients with this diagnosis is unknown. This is particularly true for patients with diabetes mellitus, who are known to ... | 0.333333 | {
"query_id": "761",
"original_query_id": "761",
"context_doc_ids": [
"34469966",
"5884524",
"13901073",
"10009203",
"8533245"
],
"gold_doc_ids_in_context": [
"10009203"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.33333333333333337,
"context_size": 5,
"generation_versi... | 761 | null |
MICAL redox enzymes regulate actin dynamics in many cell types.
The overall size and structure of a synaptic terminal is an important determinant of its function. In a large-scale mutagenesis screen, designed to identify Drosophila mutants with abnormally structured neuromuscular junctions (NMJs), we discovered mutati... | MICAL redox enzymes regulate actin dynamics in many cell types.
The overall size and structure of a synaptic terminal is an important determinant of its function. In a large-scale mutagenesis screen, designed to identify Drosophila mutants with abnormally structured neuromuscular junctions (NMJs), we discovered mutati... | 1 | {
"query_id": "737",
"original_query_id": "737",
"context_doc_ids": [
"16562534",
"6609935"
],
"gold_doc_ids_in_context": [
"16562534",
"6609935"
],
"total_gold_docs_for_query": 2,
"context_f1": 1,
"context_size": 2,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-2... | 737 | null |
Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.
Little is known about the inter-individual variation of cytokine responses to different pathogens in healthy individuals. To systematically describe cytokine responses elicited by distinct pathogens and to determine the effect ... | Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.
Little is known about the inter-individual variation of cytokine responses to different pathogens in healthy individuals. To systematically describe cytokine responses elicited by distinct pathogens and to determine the effect ... | 1 | {
"query_id": "976",
"original_query_id": "976",
"context_doc_ids": [
"5304891"
],
"gold_doc_ids_in_context": [
"5304891"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.233875",
"dataset":... | 976 | null |
Distant CREs are important for transcriptional regulation.
The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promoters and enhancers active in liver across 20 mamm... | Distant CREs are important for transcriptional regulation.
The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promoters and enhancers active in liver across 20 mamm... | 1 | {
"query_id": "351",
"original_query_id": "351",
"context_doc_ids": [
"14658685"
],
"gold_doc_ids_in_context": [
"14658685"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.233897",
"dataset... | 351 | null |
LDL cholesterol has a causal role in the development of cardiovascular disease.
Ataxia telangiectasia is a neurodegenerative disease caused by mutation of the Atm gene. Here we report that ataxia telangiectasia mutated (ATM) deficiency causes nuclear accumulation of histone deacetylase 4 (HDAC4) in neurons and promote... | LDL cholesterol has a causal role in the development of cardiovascular disease.
Ataxia telangiectasia is a neurodegenerative disease caused by mutation of the Atm gene. Here we report that ataxia telangiectasia mutated (ATM) deficiency causes nuclear accumulation of histone deacetylase 4 (HDAC4) in neurons and promote... | 0.4 | {
"query_id": "673",
"original_query_id": "673",
"context_doc_ids": [
"28369117",
"2095573",
"3113630",
"22406695"
],
"gold_doc_ids_in_context": [
"2095573"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.4,
"context_size": 4,
"generation_version": "1.0.0",
"generation_times... | 673 | null |
RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.
The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (... | RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.
The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (... | 1 | {
"query_id": "1004",
"original_query_id": "1004",
"context_doc_ids": [
"301838",
"3952288",
"2734421"
],
"gold_doc_ids_in_context": [
"301838",
"3952288",
"2734421"
],
"total_gold_docs_for_query": 3,
"context_f1": 1,
"context_size": 3,
"generation_version": "1.0.0",
"gener... | 1004 | null |
British male students are bullied more than British female students.
Variation in cerebral cortex size and complexity is thought to contribute to differences in cognitive ability between humans and other animals. Here we compare cortical progenitor cell output in humans and three nonhuman primates using directed diffe... | British male students are bullied more than British female students.
Variation in cerebral cortex size and complexity is thought to contribute to differences in cognitive ability between humans and other animals. Here we compare cortical progenitor cell output in humans and three nonhuman primates using directed diffe... | 0 | {
"query_id": "187",
"original_query_id": "187",
"context_doc_ids": [
"16939583",
"40817021",
"13956305",
"16120395",
"22696649",
"44048701"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"g... | 187 | null |
Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.
Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation. Ass... | Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.
Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation. Ass... | 0 | {
"query_id": "1028",
"original_query_id": "1028",
"context_doc_ids": [
"18111172",
"15058155",
"2095573",
"13763195",
"4406819",
"712078"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 2,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"gen... | 1028 | null |
Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.
Combinatorial transcription factor (TF) interactions control cellular phenotypes and, therefore, underpin stem cell formation, maintenance, and differentiation. Here, we report the genome-wide bin... | Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.
Combinatorial transcription factor (TF) interactions control cellular phenotypes and, therefore, underpin stem cell formation, maintenance, and differentiation. Here, we report the genome-wide bin... | 0 | {
"query_id": "277",
"original_query_id": "277",
"context_doc_ids": [
"10883736",
"33370",
"33387953",
"5483793",
"21239672",
"13048272"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"gener... | 277 | null |
Urbanization is an important risk factor related to the transmission of dengue fever.
Characterization of human monoclonal antibodies is providing considerable insight into mechanisms of broad HIV-1 neutralization. Here we report an HIV-1 gp41 membrane-proximal external region (MPER)-specific antibody, named 10E8, whi... | Urbanization is an important risk factor related to the transmission of dengue fever.
Characterization of human monoclonal antibodies is providing considerable insight into mechanisms of broad HIV-1 neutralization. Here we report an HIV-1 gp41 membrane-proximal external region (MPER)-specific antibody, named 10E8, whi... | 0.5 | {
"query_id": "1353",
"original_query_id": "1353",
"context_doc_ids": [
"18816720",
"4421578",
"17671145"
],
"gold_doc_ids_in_context": [
"18816720"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.5,
"context_size": 3,
"generation_version": "1.0.0",
"generation_timestamp": "2025... | 1353 | null |
The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.
CONTEXT Blood type and crossmatch incompatibility will exclude at least one third of patients in need from receiving a live donor kidney transplant.... | The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.
CONTEXT Blood type and crossmatch incompatibility will exclude at least one third of patients in need from receiving a live donor kidney transplant.... | 0.4 | {
"query_id": "1184",
"original_query_id": "1184",
"context_doc_ids": [
"16737210",
"25254425",
"8582337",
"4926049"
],
"gold_doc_ids_in_context": [
"16737210"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.4,
"context_size": 4,
"generation_version": "1.0.0",
"generation_ti... | 1184 | null |
The proliferative capacity of neural progenitors differs across species.
The use of N-type voltage-gated calcium channel (CaV2.2) blockers to treat pain is limited by many physiological side effects. Here we report that inflammatory and neuropathic hypersensitivity can be suppressed by inhibiting the binding of collap... | The proliferative capacity of neural progenitors differs across species.
The use of N-type voltage-gated calcium channel (CaV2.2) blockers to treat pain is limited by many physiological side effects. Here we report that inflammatory and neuropathic hypersensitivity can be suppressed by inhibiting the binding of collap... | 0.5 | {
"query_id": "1254",
"original_query_id": "1254",
"context_doc_ids": [
"16939583",
"6625693",
"12685434"
],
"gold_doc_ids_in_context": [
"16939583"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.5,
"context_size": 3,
"generation_version": "1.0.0",
"generation_timestamp": "2025... | 1254 | null |
The most prevalent adverse events to Semaglutide are gastrointestinal.
The marginal costs and benefits of converting malaria programmes from a control to an elimination goal are central to strategic decisions, but empirical evidence is scarce. We present a conceptual framework to assess the economics of elimination an... | The most prevalent adverse events to Semaglutide are gastrointestinal.
The marginal costs and benefits of converting malaria programmes from a control to an elimination goal are central to strategic decisions, but empirical evidence is scarce. We present a conceptual framework to assess the economics of elimination an... | 0 | {
"query_id": "1238",
"original_query_id": "1238",
"context_doc_ids": [
"6157837",
"5573975",
"22401061",
"16256507",
"16728949",
"21932050"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"g... | 1238 | null |
A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).
In systemic lupus erythematosus (SLE), self-reactive antibodies can target the kidney (lupus nephritis), leading to functional failure and possible mortality. We report that activation of basophils by a... | A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).
In systemic lupus erythematosus (SLE), self-reactive antibodies can target the kidney (lupus nephritis), leading to functional failure and possible mortality. We report that activation of basophils by a... | 1 | {
"query_id": "28",
"original_query_id": "28",
"context_doc_ids": [
"12670680"
],
"gold_doc_ids_in_context": [
"12670680"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.234535",
"dataset":... | 28 | null |
Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.
&NA; Immune cells communicate by exchanging cytokines to achieve a context‐appropriate response, but the distances over which such communication happens are not known. Here, we used theoretical considerations and... | Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.
&NA; Immune cells communicate by exchanging cytokines to achieve a context‐appropriate response, but the distances over which such communication happens are not known. Here, we used theoretical considerations and... | 0.4 | {
"query_id": "780",
"original_query_id": "780",
"context_doc_ids": [
"24338780",
"4928282",
"16660256"
],
"gold_doc_ids_in_context": [
"24338780"
],
"total_gold_docs_for_query": 2,
"context_f1": 0.4,
"context_size": 3,
"generation_version": "1.0.0",
"generation_timestamp": "2025-0... | 780 | null |
Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.
CONTEXT Antibody-based induction therapy plus calcineurin inhibitors (CNIs) reduce acute rejection rates in kidney recipients; however, opportunistic infections and toxic C... | Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.
CONTEXT Antibody-based induction therapy plus calcineurin inhibitors (CNIs) reduce acute rejection rates in kidney recipients; however, opportunistic infections and toxic C... | 1 | {
"query_id": "144",
"original_query_id": "144",
"context_doc_ids": [
"10582939"
],
"gold_doc_ids_in_context": [
"10582939"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.234599",
"dataset... | 144 | null |
H4 G94P proteins inhibit chromatin assembly, which decreases free histones.
T cell receptor (TCR-CD3) triggering involves both receptor clustering and conformational changes at the cytoplasmic tails of the CD3 subunits. The mechanism by which TCRalphabeta ligand binding confers conformational changes to CD3 is unknown... | H4 G94P proteins inhibit chromatin assembly, which decreases free histones.
T cell receptor (TCR-CD3) triggering involves both receptor clustering and conformational changes at the cytoplasmic tails of the CD3 subunits. The mechanism by which TCRalphabeta ligand binding confers conformational changes to CD3 is unknown... | 0 | {
"query_id": "486",
"original_query_id": "486",
"context_doc_ids": [
"34469966",
"37424881",
"33499189",
"4398832",
"20033112",
"9559146"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"gen... | 486 | null |
Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.
Healthy cells utilize intricate systems to monitor their environment and mount robust responses in the event of cellular stress. Whether stress arises from external insults or defects due to mutation and disease, cells must be able... | Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.
Healthy cells utilize intricate systems to monitor their environment and mount robust responses in the event of cellular stress. Whether stress arises from external insults or defects due to mutation and disease, cells must be able... | 1 | {
"query_id": "1046",
"original_query_id": "1046",
"context_doc_ids": [
"418246",
"4324278",
"16712164"
],
"gold_doc_ids_in_context": [
"418246",
"4324278",
"16712164"
],
"total_gold_docs_for_query": 3,
"context_f1": 1,
"context_size": 3,
"generation_version": "1.0.0",
"gen... | 1046 | null |
Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.
Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercise-in... | Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.
Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercise-in... | 1 | {
"query_id": "655",
"original_query_id": "655",
"context_doc_ids": [
"57574395"
],
"gold_doc_ids_in_context": [
"57574395"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.234745",
"dataset... | 655 | null |
Side effects associated with antidepressants increases risk of stroke.
Alzheimer's disease is the most common neurodegenerative disease, and there are no mechanism-based therapies. The disease is defined by the presence of abundant neurofibrillary lesions and neuritic plaques in the cerebral cortex. Neurofibrillary le... | Side effects associated with antidepressants increases risk of stroke.
Alzheimer's disease is the most common neurodegenerative disease, and there are no mechanism-based therapies. The disease is defined by the presence of abundant neurofibrillary lesions and neuritic plaques in the cerebral cortex. Neurofibrillary le... | 0.285714 | {
"query_id": "1084",
"original_query_id": "1084",
"context_doc_ids": [
"4446814",
"1676568",
"2052720",
"5691302",
"22995579",
"4828631"
],
"gold_doc_ids_in_context": [
"5691302"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.2857142857142857,
"context_size": 6,
"gen... | 1084 | null |
DUSP4 increases apoptosis.
Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However, many patients have residual cancer after chemotherapy, which correlates with a higher risk of metastatic recurrence and poorer outcome than those who achieve a pCR. ... | DUSP4 increases apoptosis.
Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However, many patients have residual cancer after chemotherapy, which correlates with a higher risk of metastatic recurrence and poorer outcome than those who achieve a pCR. ... | 0.4 | {
"query_id": "309",
"original_query_id": "309",
"context_doc_ids": [
"7821634",
"4828631",
"2692522",
"24512064"
],
"gold_doc_ids_in_context": [
"7821634"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.4,
"context_size": 4,
"generation_version": "1.0.0",
"generation_timest... | 309 | null |
Nonsteroidal antinflammatory drugs show potential anticancer indications.
IMPORTANCE Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risk of colorectal cancer. OBJECTIVE To identify common genetic markers that may confer differential benefit from aspirin or NSAID chemopr... | Nonsteroidal antinflammatory drugs show potential anticancer indications.
IMPORTANCE Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risk of colorectal cancer. OBJECTIVE To identify common genetic markers that may confer differential benefit from aspirin or NSAID chemopr... | 1 | {
"query_id": "857",
"original_query_id": "857",
"context_doc_ids": [
"43334921"
],
"gold_doc_ids_in_context": [
"43334921"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.234931",
"dataset... | 857 | null |
Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)
CONTEXT Whether immunosuppressive treatment adversely affects survival is unclear. OBJECTIVE To assess whether immunosuppressive drugs increase mortality. DESIGN Retrospective cohort study e... | Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)
CONTEXT Whether immunosuppressive treatment adversely affects survival is unclear. OBJECTIVE To assess whether immunosuppressive drugs increase mortality. DESIGN Retrospective cohort study e... | 1 | {
"query_id": "1126",
"original_query_id": "1126",
"context_doc_ids": [
"21009874"
],
"gold_doc_ids_in_context": [
"21009874"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.234958",
"datas... | 1126 | null |
Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.
CONTEXT Bioterrorist attacks involving letters and mail-handling systems in Washington, DC, resulted in Bacillus anthracis (anthrax) spore contamination in the Hart Senate Office Building and other facili... | Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.
CONTEXT Bioterrorist attacks involving letters and mail-handling systems in Washington, DC, resulted in Bacillus anthracis (anthrax) spore contamination in the Hart Senate Office Building and other facili... | 0.285714 | {
"query_id": "96",
"original_query_id": "96",
"context_doc_ids": [
"14500725",
"34139429",
"4928282",
"17421851",
"33872649",
"4162857"
],
"gold_doc_ids_in_context": [
"14500725"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.2857142857142857,
"context_size": 6,
"gen... | 96 | null |
Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.
As organisms develop, their tissues can become separated into distinct cell populations through the establishment of compartment boundaries. Compartment boundaries h... | Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.
As organisms develop, their tissues can become separated into distinct cell populations through the establishment of compartment boundaries. Compartment boundaries h... | 0.4 | {
"query_id": "1103",
"original_query_id": "1103",
"context_doc_ids": [
"3898784",
"9505448",
"2565138",
"38380061"
],
"gold_doc_ids_in_context": [
"3898784"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.4,
"context_size": 4,
"generation_version": "1.0.0",
"generation_time... | 1103 | null |
Mouse models can be generated using "artificial spermatids."
Haploid cells are amenable for genetic analysis. Recent success in the derivation of mouse haploid embryonic stem cells (haESCs) via parthenogenesis has enabled genetic screening in mammalian cells. However, successful generation of live animals from these h... | Mouse models can be generated using "artificial spermatids."
Haploid cells are amenable for genetic analysis. Recent success in the derivation of mouse haploid embryonic stem cells (haESCs) via parthenogenesis has enabled genetic screening in mammalian cells. However, successful generation of live animals from these h... | 1 | {
"query_id": "810",
"original_query_id": "810",
"context_doc_ids": [
"13513790"
],
"gold_doc_ids_in_context": [
"13513790"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.235159",
"dataset... | 810 | null |
The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.
The cytosolic helicase retinoic acid-inducible gene-I (RIG-I) initiates immune responses to most RNA viruses by detecting viral 5'-triphosphorylated RNA (pppRNA). Although endogenous mRNA is also 5'-triphosphorylated, b... | The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.
The cytosolic helicase retinoic acid-inducible gene-I (RIG-I) initiates immune responses to most RNA viruses by detecting viral 5'-triphosphorylated RNA (pppRNA). Although endogenous mRNA is also 5'-triphosphorylated, b... | 0.5 | {
"query_id": "1193",
"original_query_id": "1193",
"context_doc_ids": [
"24221369",
"20532591",
"791050"
],
"gold_doc_ids_in_context": [
"20532591"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.5,
"context_size": 3,
"generation_version": "1.0.0",
"generation_timestamp": "2025-... | 1193 | null |
In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.
BACKGROUND In the absence of an effective vaccine, HIV continues to spread globally, emphasizing the need for novel strategies to limit its transmission. Pr... | In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.
BACKGROUND In the absence of an effective vaccine, HIV continues to spread globally, emphasizing the need for novel strategies to limit its transmission. Pr... | 1 | {
"query_id": "582",
"original_query_id": "582",
"context_doc_ids": [
"14260013"
],
"gold_doc_ids_in_context": [
"14260013"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.235225",
"dataset... | 582 | null |
The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.
OBJECTIVE Although the Polypill concept (proposed in 2003) is promising in terms of benefits for cardiovascular risk management, the potential costs and adverse effec... | The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.
OBJECTIVE Although the Polypill concept (proposed in 2003) is promising in terms of benefits for cardiovascular risk management, the potential costs and adverse effec... | 0.333333 | {
"query_id": "1236",
"original_query_id": "1236",
"context_doc_ids": [
"6157837",
"17973161",
"8780599",
"301838",
"25254425"
],
"gold_doc_ids_in_context": [
"17973161"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.33333333333333337,
"context_size": 5,
"generation_versi... | 1236 | null |
Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.
Studying how protein transmembrane domains transmit signals across membranes is beset by unique challenges. Here, we discuss the circumstances that have led to success and reflect on what has been learned from these exa... | Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.
Studying how protein transmembrane domains transmit signals across membranes is beset by unique challenges. Here, we discuss the circumstances that have led to success and reflect on what has been learned from these exa... | 0.5 | {
"query_id": "617",
"original_query_id": "617",
"context_doc_ids": [
"16999023",
"17123657",
"18670"
],
"gold_doc_ids_in_context": [
"18670"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.5,
"context_size": 3,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T... | 617 | null |
DRD1 proteins enable Pol V transcription in vivo.
Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete IL-1β independently of classical inflammasome stimuli. Here, we report that this constituted a sp... | DRD1 proteins enable Pol V transcription in vivo.
Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete IL-1β independently of classical inflammasome stimuli. Here, we report that this constituted a sp... | 0 | {
"query_id": "305",
"original_query_id": "305",
"context_doc_ids": [
"34469966",
"18956141",
"8002887",
"27123743",
"1215116",
"4740447"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"gene... | 305 | null |
Tirasemtiv targets fast-twitch muscle.
Limited neural input results in muscle weakness in neuromuscular disease because of a reduction in the density of muscle innervation, the rate of neuromuscular junction activation or the efficiency of synaptic transmission. We developed a small-molecule fast-skeletal-troponin act... | Tirasemtiv targets fast-twitch muscle.
Limited neural input results in muscle weakness in neuromuscular disease because of a reduction in the density of muscle innervation, the rate of neuromuscular junction activation or the efficiency of synaptic transmission. We developed a small-molecule fast-skeletal-troponin act... | 1 | {
"query_id": "1305",
"original_query_id": "1305",
"context_doc_ids": [
"12631697"
],
"gold_doc_ids_in_context": [
"12631697"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.235438",
"datas... | 1305 | null |
Anthrax spores remain deadly until affected areas are decontaminated.
CONTEXT Bioterrorist attacks involving letters and mail-handling systems in Washington, DC, resulted in Bacillus anthracis (anthrax) spore contamination in the Hart Senate Office Building and other facilities in the US Capitol's vicinity. OBJECTIVE ... | Anthrax spores remain deadly until affected areas are decontaminated.
CONTEXT Bioterrorist attacks involving letters and mail-handling systems in Washington, DC, resulted in Bacillus anthracis (anthrax) spore contamination in the Hart Senate Office Building and other facilities in the US Capitol's vicinity. OBJECTIVE ... | 1 | {
"query_id": "116",
"original_query_id": "116",
"context_doc_ids": [
"33872649"
],
"gold_doc_ids_in_context": [
"33872649"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.235455",
"dataset... | 116 | null |
Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.
The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary th... | Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.
The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary th... | 0.285714 | {
"query_id": "104",
"original_query_id": "104",
"context_doc_ids": [
"27873158",
"21387297",
"6766459",
"301838",
"40164383",
"26112696"
],
"gold_doc_ids_in_context": [
"40164383"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.2857142857142857,
"context_size": 6,
"ge... | 104 | null |
PCSK9 inhibitors decrease plasma Lp(a) levels.
BACKGROUND Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (apoB). Although studies in mice and cells have identified increased hepatic LDL receptor... | PCSK9 inhibitors decrease plasma Lp(a) levels.
BACKGROUND Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (apoB). Although studies in mice and cells have identified increased hepatic LDL receptor... | 1 | {
"query_id": "901",
"original_query_id": "901",
"context_doc_ids": [
"6540064"
],
"gold_doc_ids_in_context": [
"6540064"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.235581",
"dataset":... | 901 | null |
EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.
Genome-wide association studies are now identifying disease-associated chromosome regions. However, even after convincing replication, the localization of the causal variant(s) requires comprehensive resequen... | EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.
Genome-wide association studies are now identifying disease-associated chromosome regions. However, even after convincing replication, the localization of the causal variant(s) requires comprehensive resequen... | 0.5 | {
"query_id": "363",
"original_query_id": "363",
"context_doc_ids": [
"13940200",
"5386514",
"2565138"
],
"gold_doc_ids_in_context": [
"5386514"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.5,
"context_size": 3,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-... | 363 | null |
Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.
The TLX1 and TLX3 transcription factor oncogenes have a key role in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL). Here we used reverse engineering of global transcriptional networks to dec... | Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.
The TLX1 and TLX3 transcription factor oncogenes have a key role in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL). Here we used reverse engineering of global transcriptional networks to dec... | 0.285714 | {
"query_id": "854",
"original_query_id": "854",
"context_doc_ids": [
"12206390",
"1797622",
"19912367",
"1982286",
"16999023",
"19313533"
],
"gold_doc_ids_in_context": [
"12206390"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.2857142857142857,
"context_size": 6,
"g... | 854 | null |
Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.
Embryonic stem (ES) cell lines derived from human blastocysts have the developmental potential to form derivatives of all three embryonic germ layers even after prolonged culture. Here... | Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.
Embryonic stem (ES) cell lines derived from human blastocysts have the developmental potential to form derivatives of all three embryonic germ layers even after prolonged culture. Here... | 0.285714 | {
"query_id": "531",
"original_query_id": "531",
"context_doc_ids": [
"16361581",
"25413327",
"6903077",
"11603066"
],
"gold_doc_ids_in_context": [
"25413327"
],
"total_gold_docs_for_query": 3,
"context_f1": 0.28571428571428575,
"context_size": 4,
"generation_version": "1.0.0",
... | 531 | null |
Low nucleosome occupancy correlates with high methylation levels across species.
Dnmt1 epigenetically propagates symmetrical CG methylation in many eukaryotes. Their genomes are typically depleted of CG dinucleotides because of imperfect repair of deaminated methylcytosines. Here, we extensively survey diverse species... | Low nucleosome occupancy correlates with high methylation levels across species.
Dnmt1 epigenetically propagates symmetrical CG methylation in many eukaryotes. Their genomes are typically depleted of CG dinucleotides because of imperfect repair of deaminated methylcytosines. Here, we extensively survey diverse species... | 1 | {
"query_id": "717",
"original_query_id": "717",
"context_doc_ids": [
"17587795"
],
"gold_doc_ids_in_context": [
"17587795"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.235775",
"dataset... | 717 | null |
HAND2 methylation is a key step in early endometrial carcinogenesis.
Two-component signal transduction pathways comprising histidine protein kinases (HPKs) and their response regulators (RRs) are widely used to control bacterial responses to environmental challenges. Some bacteria have over 150 different two-component... | HAND2 methylation is a key step in early endometrial carcinogenesis.
Two-component signal transduction pathways comprising histidine protein kinases (HPKs) and their response regulators (RRs) are widely used to control bacterial responses to environmental challenges. Some bacteria have over 150 different two-component... | 0.5 | {
"query_id": "488",
"original_query_id": "488",
"context_doc_ids": [
"1780819",
"1522647",
"11603066"
],
"gold_doc_ids_in_context": [
"1780819"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.5,
"context_size": 3,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-... | 488 | null |
miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.
Nanotechnologies are emerging platforms that could be useful in measuring, understanding, and manipulating stem cells. Examples include magnetic nanoparticles and quantum dots for stem cell labeling and in vivo tracking; nanoparticles, carbon... | miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.
Nanotechnologies are emerging platforms that could be useful in measuring, understanding, and manipulating stem cells. Examples include magnetic nanoparticles and quantum dots for stem cell labeling and in vivo tracking; nanoparticles, carbon... | 0 | {
"query_id": "1393",
"original_query_id": "1393",
"context_doc_ids": [
"14853989",
"4455466",
"5151024",
"2251426",
"31715818",
"195689316"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 2,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"g... | 1393 | null |
Normal granulomas form in the presence of TNF in Zebrafish.
Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert protection by directing formation of granulomas, organized aggregates of macrophages and other immune cells. Loss of TNF signaling causes progression of tuberculosis ... | Normal granulomas form in the presence of TNF in Zebrafish.
Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert protection by directing formation of granulomas, organized aggregates of macrophages and other immune cells. Loss of TNF signaling causes progression of tuberculosis ... | 1 | {
"query_id": "861",
"original_query_id": "861",
"context_doc_ids": [
"16066726"
],
"gold_doc_ids_in_context": [
"16066726"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.236117",
"dataset... | 861 | null |
The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.
The oncogenic BCR/ABL tyrosine kinase induces constitutive DNA damage in Philadelphia chromosome (Ph)-positive leukemia cells. We find that BCR/ABL-induced reactive oxygen species (ROSs... | The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.
The oncogenic BCR/ABL tyrosine kinase induces constitutive DNA damage in Philadelphia chromosome (Ph)-positive leukemia cells. We find that BCR/ABL-induced reactive oxygen species (ROSs... | 1 | {
"query_id": "1220",
"original_query_id": "1220",
"context_doc_ids": [
"13023410"
],
"gold_doc_ids_in_context": [
"13023410"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.236137",
"datas... | 1220 | null |
GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.
Maintaining hematopoietic stem cell (HSC) quiescence is a critical property for the life-long generation of blood cells. Approximately 75% of cells in a highly enriched long-term repopulating HSC (LT-HSC) pool (Lin(-)Sca1(+)c-Kit(hi)CD150(+... | GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.
Maintaining hematopoietic stem cell (HSC) quiescence is a critical property for the life-long generation of blood cells. Approximately 75% of cells in a highly enriched long-term repopulating HSC (LT-HSC) pool (Lin(-)Sca1(+)c-Kit(hi)CD150(+... | 1 | {
"query_id": "445",
"original_query_id": "445",
"context_doc_ids": [
"10165258"
],
"gold_doc_ids_in_context": [
"10165258"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.236151",
"dataset... | 445 | null |
Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.
EBI2, aka GPR183, is a G-couple receptor originally identified in 1993 as one of main genes induced in Burkitt's lymphoma cell line BL41 by Epstein-Barr virus (EBV) infection. After it was reported in 2009 that the receptor played a... | Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.
EBI2, aka GPR183, is a G-couple receptor originally identified in 1993 as one of main genes induced in Burkitt's lymphoma cell line BL41 by Epstein-Barr virus (EBV) infection. After it was reported in 2009 that the receptor played a... | 0 | {
"query_id": "447",
"original_query_id": "447",
"context_doc_ids": [
"15058155",
"5114282",
"3863543",
"1710116",
"33872649",
"22544171"
],
"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"gene... | 447 | null |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.