query stringclasses 184
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values | label float64 0 1 | metadata dict | query_id stringclasses 184
values | id stringlengths 7 7 ⌀ |
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Monoclonal antibody targeting of N-cadherin inhibits castration resistance.
Dendritic cells (DCs) are essential antigen-presenting cells for the induction of immunity against pathogens. However, HIV-1 spread is strongly enhanced in clusters of DCs and CD4(+) T cells. Uninfected DCs capture HIV-1 and mediate viral tran... | Monoclonal antibody targeting of N-cadherin inhibits castration resistance.
Dendritic cells (DCs) are essential antigen-presenting cells for the induction of immunity against pathogens. However, HIV-1 spread is strongly enhanced in clusters of DCs and CD4(+) T cells. Uninfected DCs capture HIV-1 and mediate viral tran... | 0 | {
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B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.
Plants have evolved a tremendous ability to respond to environmental changes by adapting their growth and development. The interaction between hormonal and developmental ... | B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.
Plants have evolved a tremendous ability to respond to environmental changes by adapting their growth and development. The interaction between hormonal and developmental ... | 0 | {
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Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.
Cancer stem cells drive tumor formation and metastasis, but how they acquire metastatic traits is not well understood. Here, we show that all colorectal cancer stem cells (CR-CSCs) exp... | Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.
Cancer stem cells drive tumor formation and metastasis, but how they acquire metastatic traits is not well understood. Here, we show that all colorectal cancer stem cells (CR-CSCs) exp... | 0.333333 | {
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Roughly 55% of women with chronic pelvic pain have no underlying pathology.
CONTEXT Chronic pelvic pain is a common condition with a major effect on health-related quality of life, work productivity, and health care use. Operative interruption of nerve trunks in the uterosacral ligaments by laparoscopic uterosacral ne... | Roughly 55% of women with chronic pelvic pain have no underlying pathology.
CONTEXT Chronic pelvic pain is a common condition with a major effect on health-related quality of life, work productivity, and health care use. Operative interruption of nerve trunks in the uterosacral ligaments by laparoscopic uterosacral ne... | 1 | {
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Expression of oncolytic virus antigens as peptides makes relapse more likely.
To identify previously unknown platelet receptors we compared the transcriptomes of in vitro differentiated megakaryocytes (MKs) and erythroblasts (EBs). RNA was obtained from purified, biologically paired MK and EB cultures and compared usi... | Expression of oncolytic virus antigens as peptides makes relapse more likely.
To identify previously unknown platelet receptors we compared the transcriptomes of in vitro differentiated megakaryocytes (MKs) and erythroblasts (EBs). RNA was obtained from purified, biologically paired MK and EB cultures and compared usi... | 0.333333 | {
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BiP is a general endoplasmic reticulum stress marker.
IMPORTANCE Studies suggest pioglitazone use may increase risk of cancers. OBJECTIVE To examine whether pioglitazone use for diabetes is associated with risk of bladder and 10 additional cancers. DESIGN, SETTING, AND PARTICIPANTS Cohort and nested case-control analy... | BiP is a general endoplasmic reticulum stress marker.
IMPORTANCE Studies suggest pioglitazone use may increase risk of cancers. OBJECTIVE To examine whether pioglitazone use for diabetes is associated with risk of bladder and 10 additional cancers. DESIGN, SETTING, AND PARTICIPANTS Cohort and nested case-control analy... | 0.5 | {
"query_id": "176",
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"generation_timestamp": "2025-07... | 176 | null |
Misunderstandings between doctors and patients can lead to non-adherence.
Self-renewal and differentiation of stem cells depend on asymmetric division and polarized motility processes that in other cell types are modulated by nonmuscle myosin-II (MII) forces and matrix mechanics. Here, mass spectrometry-calibrated int... | Misunderstandings between doctors and patients can lead to non-adherence.
Self-renewal and differentiation of stem cells depend on asymmetric division and polarized motility processes that in other cell types are modulated by nonmuscle myosin-II (MII) forces and matrix mechanics. Here, mass spectrometry-calibrated int... | 0 | {
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Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.
Here we studied cell-free plasma DNA (cfDNA) collected from subjects with advanced lung cancer whose tumors had developed resistance to the epidermal ... | Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.
Here we studied cell-free plasma DNA (cfDNA) collected from subjects with advanced lung cancer whose tumors had developed resistance to the epidermal ... | 0 | {
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NR5A2 is important in reverse cholesterol transport in humans.
The regulated release of anorexigenic α-melanocyte stimulating hormone (α-MSH) and orexigenic Agouti-related protein (AgRP) from discrete hypothalamic arcuate neurons onto common target sites in the central nervous system has a fundamental role in the regu... | NR5A2 is important in reverse cholesterol transport in humans.
The regulated release of anorexigenic α-melanocyte stimulating hormone (α-MSH) and orexigenic Agouti-related protein (AgRP) from discrete hypothalamic arcuate neurons onto common target sites in the central nervous system has a fundamental role in the regu... | 0 | {
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Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.
Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE). Here we have provided evidence for the involvement of a damage-associated DNA modification in the detectio... | Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.
Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE). Here we have provided evidence for the involvement of a damage-associated DNA modification in the detectio... | 0.333333 | {
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Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media.
The organization of cells, emerging from cell-cell interactions, can give rise to collective properties. These properties are adaptive when together cells can face environ... | Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media.
The organization of cells, emerging from cell-cell interactions, can give rise to collective properties. These properties are adaptive when together cells can face environ... | 1 | {
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The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.
Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in the pathogenesis of infla... | The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.
Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in the pathogenesis of infla... | 1 | {
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Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.
Circadian cycles and cell cycles are two fundamental periodic processes with a period in the range of 1 day. Consequently, coupling between such cycles can lead ... | Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.
Circadian cycles and cell cycles are two fundamental periodic processes with a period in the range of 1 day. Consequently, coupling between such cycles can lead ... | 0 | {
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Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.
BACKGROUND Histone deimination regulates gene function and contributes to antimicrobial response, allowing the formation of neutrophil extracellular traps (NETs). Deiminated proteins are target of anti-citrullinated peptides ... | Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.
BACKGROUND Histone deimination regulates gene function and contributes to antimicrobial response, allowing the formation of neutrophil extracellular traps (NETs). Deiminated proteins are target of anti-citrullinated peptides ... | 0 | {
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GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.
RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing. Using an in vitro transcription/splicing assay, we demonstrate that an association of ... | GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.
RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing. Using an in vitro transcription/splicing assay, we demonstrate that an association of ... | 0.333333 | {
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Treatment with a protein named FN impairs regenerative abilities of aged muscles.
Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation. Association of the RNA-binding protein HuR with... | Treatment with a protein named FN impairs regenerative abilities of aged muscles.
Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation. Association of the RNA-binding protein HuR with... | 0.333333 | {
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1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.
Apart from HIV two exogenous retroviruses (human T cell leukaemia viruses type I (HTLV-I) and type II (HTLV-II)) infect humans. HTLV-I infection is endemic in Japan, the Caribbean, Africa, and Melanesia and is found among immigrants ... | 1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.
Apart from HIV two exogenous retroviruses (human T cell leukaemia viruses type I (HTLV-I) and type II (HTLV-II)) infect humans. HTLV-I infection is endemic in Japan, the Caribbean, Africa, and Melanesia and is found among immigrants ... | 0 | {
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Satellite cell dysfunction is a key factor in sarcopenia development.
A key determinant of geriatric frailty is sarcopenia, the age-associated loss of skeletal muscle mass and strength. Although the etiology of sarcopenia is unknown, the correlation during aging between the loss of activity of satellite cells, which a... | Satellite cell dysfunction is a key factor in sarcopenia development.
A key determinant of geriatric frailty is sarcopenia, the age-associated loss of skeletal muscle mass and strength. Although the etiology of sarcopenia is unknown, the correlation during aging between the loss of activity of satellite cells, which a... | 1 | {
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Myelin sheaths play a role in action potential propagation.
BACKGROUND Information is scarce about the combined effects on breast cancer incidence of low-penetrance genetic susceptibility polymorphisms and environmental factors (reproductive, behavioural, and anthropometric risk factors for breast cancer). To test for... | Myelin sheaths play a role in action potential propagation.
BACKGROUND Information is scarce about the combined effects on breast cancer incidence of low-penetrance genetic susceptibility polymorphisms and environmental factors (reproductive, behavioural, and anthropometric risk factors for breast cancer). To test for... | 0 | {
"query_id": "818",
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Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.
Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze protein crosslinking, plays an important role in the extracellular matrix biology of many tissues and is implicated in the gluten-induced pathoge... | Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.
Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze protein crosslinking, plays an important role in the extracellular matrix biology of many tissues and is implicated in the gluten-induced pathoge... | 0.333333 | {
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Active caspase-11 participate in regulating phagosome-lysosome fusion.
OBJECTIVE To assess whether population screening for impaired vision among older people in the community leads to improvements in vision. DESIGN Systematic review of randomised controlled trials of population screening in the community that include... | Active caspase-11 participate in regulating phagosome-lysosome fusion.
OBJECTIVE To assess whether population screening for impaired vision among older people in the community leads to improvements in vision. DESIGN Systematic review of randomised controlled trials of population screening in the community that include... | 0.5 | {
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Peroxynitrite is required for induction of T cell tolerance.
Antigen-specific CD8+ T-cell tolerance, induced by myeloid-derived suppressor cells (MDSCs), is one of the main mechanisms of tumor escape. Using in vivo models, we show here that MDSCs directly disrupt the binding of specific peptide–major histocompatibilit... | Peroxynitrite is required for induction of T cell tolerance.
Antigen-specific CD8+ T-cell tolerance, induced by myeloid-derived suppressor cells (MDSCs), is one of the main mechanisms of tumor escape. Using in vivo models, we show here that MDSCs directly disrupt the binding of specific peptide–major histocompatibilit... | 0.5 | {
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Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.
Glial cells perform critical functions that alter the metabolism and activity of neurons, and there is increasing interest in their role in appetite and energy balance. Leptin, a key regulator of a... | Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.
Glial cells perform critical functions that alter the metabolism and activity of neurons, and there is increasing interest in their role in appetite and energy balance. Leptin, a key regulator of a... | 0.4 | {
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Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.
Despite growing interest and a recent surge in papers, the role of autophagy in glucose and lipid metabolism is unclear. We produced mice with skeletal muscle–specific deletion of Atg7 (encoding ... | Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.
Despite growing interest and a recent surge in papers, the role of autophagy in glucose and lipid metabolism is unclear. We produced mice with skeletal muscle–specific deletion of Atg7 (encoding ... | 0.333333 | {
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Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.
Aire-expressing medullary thymic epithelial cells (mTECs) play a key role in preventing autoimmunity by expressing tissue-restricted antigens to help purge the emerging T cell r... | Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.
Aire-expressing medullary thymic epithelial cells (mTECs) play a key role in preventing autoimmunity by expressing tissue-restricted antigens to help purge the emerging T cell r... | 0 | {
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Retinoic acid receptor-related orphan receptor gamma (RORγ) is a therapeutic target for castration-resistant prostate cancer (CRPC)
It is becoming “a truth universally acknowledged” that the education of undergraduate medical students will be enhanced through the use of computer assisted learning. Access to the wide r... | Retinoic acid receptor-related orphan receptor gamma (RORγ) is a therapeutic target for castration-resistant prostate cancer (CRPC)
It is becoming “a truth universally acknowledged” that the education of undergraduate medical students will be enhanced through the use of computer assisted learning. Access to the wide r... | 0 | {
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"g... | 1043 | null |
Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.
Blood monocytes are well-characterized precursors for macrophages and dendritic cells. Subsets of human monocytes with differential representation in various disease states are well known. In contrast, mouse monocyte ... | Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.
Blood monocytes are well-characterized precursors for macrophages and dendritic cells. Subsets of human monocytes with differential representation in various disease states are well known. In contrast, mouse monocyte ... | 0 | {
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Lack of FGF21 in mice leads to reduced lifespan.
Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interactions between tumor growth/m... | Lack of FGF21 in mice leads to reduced lifespan.
Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interactions between tumor growth/m... | 0.5 | {
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The DESMOND program caused substantial weight loss in most participants.
OBJECTIVE To measure whether the benefits of a single education and self management structured programme for people with newly diagnosed type 2 diabetes mellitus are sustained at three years. DESIGN Three year follow-up of a multicentre cluster r... | The DESMOND program caused substantial weight loss in most participants.
OBJECTIVE To measure whether the benefits of a single education and self management structured programme for people with newly diagnosed type 2 diabetes mellitus are sustained at three years. DESIGN Three year follow-up of a multicentre cluster r... | 1 | {
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The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.
L3mbtl2 has been implicated in transcriptional repression and chromat... | The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.
L3mbtl2 has been implicated in transcriptional repression and chromat... | 1 | {
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"datas... | 1218 | null |
HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).
BACKGROUND The large-scale emigration of physicians from sub-Saharan Africa (SSA) to high-income nations is a serious development concern. Our objective was to determine current emigration trends of SSA physicians foun... | HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).
BACKGROUND The large-scale emigration of physicians from sub-Saharan Africa (SSA) to high-income nations is a serious development concern. Our objective was to determine current emigration trends of SSA physicians foun... | 0 | {
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In British Men, haplogroup I decreases risk of cardiovascular disease.
BACKGROUND A sexual dimorphism exists in the incidence and prevalence of coronary artery disease--men are more commonly affected than are age-matched women. We explored the role of the Y chromosome in coronary artery disease in the context of this ... | In British Men, haplogroup I decreases risk of cardiovascular disease.
BACKGROUND A sexual dimorphism exists in the incidence and prevalence of coronary artery disease--men are more commonly affected than are age-matched women. We explored the role of the Y chromosome in coronary artery disease in the context of this ... | 1 | {
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"dataset":... | 563 | null |
H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.
Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops. A... | H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.
Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops. A... | 1 | {
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"dataset... | 485 | null |
A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.
CONTEXT Diagnostic lumbar punctures (LPs), commonly used to rule out meningitis, are associated with adverse events. OBJECTIVE To systematically review the evidence about diagnostic LP techniques that may ... | A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.
CONTEXT Diagnostic lumbar punctures (LPs), commonly used to rule out meningitis, are associated with adverse events. OBJECTIVE To systematically review the evidence about diagnostic LP techniques that may ... | 0 | {
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"genera... | 41 | null |
Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.
OBJECTIVE To determine whether ultrasound imaging can reduce the risk of failed lumbar punctures or epidural catheterisations, when compared with standard palpation methods, and whether ultrasound imaging... | Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.
OBJECTIVE To determine whether ultrasound imaging can reduce the risk of failed lumbar punctures or epidural catheterisations, when compared with standard palpation methods, and whether ultrasound imaging... | 1 | {
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"datas... | 1340 | null |
Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.
Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with recipr... | Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.
Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with recipr... | 1 | {
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"datas... | 1331 | null |
Malaria has a high vectorial capacity.
Experience gained from the Global Malaria Eradication Program (1955-72) identified a set of shared technical and operational factors that enabled some countries to successfully eliminate malaria. Spatial data for these factors were assembled for all malaria-endemic countries and ... | Malaria has a high vectorial capacity.
Experience gained from the Global Malaria Eradication Program (1955-72) identified a set of shared technical and operational factors that enabled some countries to successfully eliminate malaria. Spatial data for these factors were assembled for all malaria-endemic countries and ... | 1 | {
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"dataset":... | 753 | null |
Medications to treat obesity do not have side effects.
The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key pathogenic event. Neutrophils isolated from patients with various autoimmune dise... | Medications to treat obesity do not have side effects.
The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key pathogenic event. Neutrophils isolated from patients with various autoimmune dise... | 0.4 | {
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"generation_timest... | 765 | null |
Cost effectiveness evaluations based on cRCT data lack external validity.
BACKGROUND Data on absolute risks of outcomes and patterns of drug use in cost-effectiveness analyses are often based on randomised clinical trials (RCTs). The objective of this study was to evaluate the external validity of published cost-effec... | Cost effectiveness evaluations based on cRCT data lack external validity.
BACKGROUND Data on absolute risks of outcomes and patterns of drug use in cost-effectiveness analyses are often based on randomised clinical trials (RCTs). The objective of this study was to evaluate the external validity of published cost-effec... | 1 | {
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"dataset... | 292 | null |
Progerin induces premature aging in stem cells.
Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation. Association of the RNA-binding protein HuR with lincRNA-p21 favored the recruitme... | Progerin induces premature aging in stem cells.
Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation. Association of the RNA-binding protein HuR with lincRNA-p21 favored the recruitme... | 0 | {
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"generation_version": "1.0.0",
"ge... | 979 | null |
Myelin sheaths are lipid-rich cellular structures.
We report a newly developed technique for high-resolution in vivo imaging of myelinated axons in the brain, spinal cord and peripheral nerve that requires no fluorescent labeling. This method, based on spectral confocal reflectance microscopy (SCoRe), uses a conventio... | Myelin sheaths are lipid-rich cellular structures.
We report a newly developed technique for high-resolution in vivo imaging of myelinated axons in the brain, spinal cord and peripheral nerve that requires no fluorescent labeling. This method, based on spectral confocal reflectance microscopy (SCoRe), uses a conventio... | 0.285714 | {
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"... | 817 | null |
Monoclonal antibody targeting of N-cadherin encourages metastasis.
Biological systems use a variety of mechanisms to maintain their functions in the face of environmental and genetic perturbations. Increasing evidence suggests that, among their roles as posttranscriptional repressors of gene expression, microRNAs (miR... | Monoclonal antibody targeting of N-cadherin encourages metastasis.
Biological systems use a variety of mechanisms to maintain their functions in the face of environmental and genetic perturbations. Increasing evidence suggests that, among their roles as posttranscriptional repressors of gene expression, microRNAs (miR... | 0.285714 | {
"query_id": "802",
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"... | 802 | null |
CHOP is a general endoplasmic reticulum stress marker.
Over the past two decades there have been significant achievements in the control of a handful of important human tropical infections [1]. These achievements include the substantive reductions in the prevalence and incidence of the so-called neglected diseases suc... | CHOP is a general endoplasmic reticulum stress marker.
Over the past two decades there have been significant achievements in the control of a handful of important human tropical infections [1]. These achievements include the substantive reductions in the prevalence and incidence of the so-called neglected diseases suc... | 0.333333 | {
"query_id": "209",
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"generation_versio... | 209 | null |
Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.
In single-stranded ribonucleic acid (RNA) viruses, virus capsid assembly and genome packaging are intertwined processes. Using cryo-electron microscopy and single particle analysis we determin... | Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.
In single-stranded ribonucleic acid (RNA) viruses, virus capsid assembly and genome packaging are intertwined processes. Using cryo-electron microscopy and single particle analysis we determin... | 0 | {
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"original_query_id": "621",
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"gene... | 621 | null |
Antimicrobial agents are more effective due to the pressure of antimicrobial usage.
Overusing antibiotics is not the only cause and reducing use is not the only solution W arning signs of antimicrobial resistance, chinks in the antimicrobial armour, began to appear in the middle of the last century, and by the 1990s... | Antimicrobial agents are more effective due to the pressure of antimicrobial usage.
Overusing antibiotics is not the only cause and reducing use is not the only solution W arning signs of antimicrobial resistance, chinks in the antimicrobial armour, began to appear in the middle of the last century, and by the 1990s... | 1 | {
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"dataset... | 122 | null |
Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.
It is becoming “a truth universally acknowledged” that the education of undergraduate medical students will be enhanced through the use of computer assisted learning. Access to the wide range of online opt... | Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.
It is becoming “a truth universally acknowledged” that the education of undergraduate medical students will be enhanced through the use of computer assisted learning. Access to the wide range of online opt... | 0 | {
"query_id": "504",
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"generation_version": "1.0.0",
"genera... | 504 | null |
VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.
BACKGROUND Although unstable coronary artery disease is the most common reason for admission to a coronary care unit, the long-term prognosis of patients with this diagnosis is unknown. This is particularly true for patients w... | VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.
BACKGROUND Although unstable coronary artery disease is the most common reason for admission to a coronary care unit, the long-term prognosis of patients with this diagnosis is unknown. This is particularly true for patients w... | 0 | {
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"gene... | 1366 | null |
Pharmacist attendance at ward rounds reduces adverse events in wards.
Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops. Although chromos... | Pharmacist attendance at ward rounds reduces adverse events in wards.
Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops. Although chromos... | 0 | {
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"generation_version": "1.0.0",
"gen... | 941 | null |
Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.
Defined genetic models based on human pluripotent stem cells have opened new avenues for understanding disease mechanisms and drug screening. Many of these models assume cell-autonomous mechanisms of disease but it is possible th... | Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.
Defined genetic models based on human pluripotent stem cells have opened new avenues for understanding disease mechanisms and drug screening. Many of these models assume cell-autonomous mechanisms of disease but it is possible th... | 0.4 | {
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"generation_t... | 1090 | null |
The innate immune response struggles to remove small numbers of parasites.
Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops. Although ch... | The innate immune response struggles to remove small numbers of parasites.
Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops. Although ch... | 0.285714 | {
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"... | 1223 | null |
A deficiency of vitamin B6 decreases blood levels of homocysteine.
OBJECTIVE To establish the mental health needs of homeless children and families before and after rehousing. DESIGN Cross sectional, longitudinal study. SETTING City of Birmingham. SUBJECTS 58 rehoused families with 103 children aged 2-16 years and 21 ... | A deficiency of vitamin B6 decreases blood levels of homocysteine.
OBJECTIVE To establish the mental health needs of homeless children and families before and after rehousing. DESIGN Cross sectional, longitudinal study. SETTING City of Birmingham. SUBJECTS 58 rehoused families with 103 children aged 2-16 years and 21 ... | 0 | {
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"generation_version": "1.0.0",
"genera... | 37 | null |
Rising temperatures caused by global warming increases risk of dengue fever transmission.
BACKGROUND Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors related to the human host, virus, mosquito vect... | Rising temperatures caused by global warming increases risk of dengue fever transmission.
BACKGROUND Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors related to the human host, virus, mosquito vect... | 0.285714 | {
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... | 1052 | null |
Hypothalamic glutamate neurotransmission is unrelated to energy balance.
The importance of neuropeptides in the hypothalamus has been experimentally established. Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters glutamate and GABA are largely unknown. Synaptic vesicular ... | Hypothalamic glutamate neurotransmission is unrelated to energy balance.
The importance of neuropeptides in the hypothalamus has been experimentally established. Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters glutamate and GABA are largely unknown. Synaptic vesicular ... | 1 | {
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"generation_version": "1.0.0",
... | 541 | null |
Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.
BACKGROUND Interferon-gamma (IFN-gamma) is an essential cytokine in the regulation of inflammatory responses in autoimmune diseases. Little is known about its role in inflammatory heart disease. METHODS AND RESULTS We... | Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.
BACKGROUND Interferon-gamma (IFN-gamma) is an essential cytokine in the regulation of inflammatory responses in autoimmune diseases. Little is known about its role in inflammatory heart disease. METHODS AND RESULTS We... | 0.285714 | {
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"ge... | 635 | null |
MICAL redox enzymes regulate actin dynamics.
Semaphorin3A (Sema3A) is a repulsive guidance molecule for axons, which acts by inducing growth cone collapse through phosphorylation of CRMP2 (collapsin response mediator protein 2). Here, we show a role for CRMP2 oxidation and thioredoxin (TRX) in the regulation of CRMP2 ... | MICAL redox enzymes regulate actin dynamics.
Semaphorin3A (Sema3A) is a repulsive guidance molecule for axons, which acts by inducing growth cone collapse through phosphorylation of CRMP2 (collapsin response mediator protein 2). Here, we show a role for CRMP2 oxidation and thioredoxin (TRX) in the regulation of CRMP2 ... | 1 | {
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"generation_version": "1.0.0",
"g... | 738 | null |
Bcp1 is a chaperone for Rpl23.
Biogenesis of ribosomes is an essential cellular process conserved across all eukaryotes and is known to require >170 genes for the assembly, modification, and trafficking of ribosome components through multiple cellular compartments. Despite intensive study, this pathway likely involves... | Bcp1 is a chaperone for Rpl23.
Biogenesis of ribosomes is an essential cellular process conserved across all eukaryotes and is known to require >170 genes for the assembly, modification, and trafficking of ribosome components through multiple cellular compartments. Despite intensive study, this pathway likely involves... | 1 | {
"query_id": "173",
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"generation_timestamp": "2025-07-24T12:04:39.239846",
"dataset":... | 173 | null |
Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)
Hutchinson-Gilford progeria syndrome (HGPS) is a childhood premature aging disease caused by a spontaneous point mutation in lamin A (encoded by LMNA), one of the major... | Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)
Hutchinson-Gilford progeria syndrome (HGPS) is a childhood premature aging disease caused by a spontaneous point mutation in lamin A (encoded by LMNA), one of the major... | 0.285714 | {
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Antidepressants increase the severity of migraines.
CONTEXT The antioxidant acetylcysteine prevents acute contrast nephrotoxicity in patients with impaired renal function who undergo computed tomography scanning. However, its role in coronary angiography is unclear. OBJECTIVE To determine whether oral acetylcysteine p... | Antidepressants increase the severity of migraines.
CONTEXT The antioxidant acetylcysteine prevents acute contrast nephrotoxicity in patients with impaired renal function who undergo computed tomography scanning. However, its role in coronary angiography is unclear. OBJECTIVE To determine whether oral acetylcysteine p... | 0.285714 | {
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Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.
The functional heart is comprised of distinct mesoderm-derived lineages including cardiomyocytes, endothelial cells and vascular smooth muscle cells. Studies in the mouse embryo and the mouse embryonic stem cell differentiation model have... | Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.
The functional heart is comprised of distinct mesoderm-derived lineages including cardiomyocytes, endothelial cells and vascular smooth muscle cells. Studies in the mouse embryo and the mouse embryonic stem cell differentiation model have... | 0.285714 | {
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"ge... | 645 | null |
DUSP4 downregulation deactivates the Ras-ERK pathway
BMP is thought to induce hESC differentiation toward multiple lineages including mesoderm and trophoblast. The BMP-induced trophoblast phenotype is a long-standing paradox in stem cell biology. Here we readdressed BMP function in hESCs and mouse epiblast-derived cel... | DUSP4 downregulation deactivates the Ras-ERK pathway
BMP is thought to induce hESC differentiation toward multiple lineages including mesoderm and trophoblast. The BMP-induced trophoblast phenotype is a long-standing paradox in stem cell biology. Here we readdressed BMP function in hESCs and mouse epiblast-derived cel... | 0.4 | {
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Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.
Cells from organisms with renewable tissues can permanently withdraw from the cell cycle in response to diverse stress, including dysfunctional... | Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.
Cells from organisms with renewable tissues can permanently withdraw from the cell cycle in response to diverse stress, including dysfunctional... | 0.5 | {
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The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.
Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in the pathogenesis of inflamm... | The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.
Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in the pathogenesis of inflamm... | 1 | {
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Treatment with a protein named FN restores regenerative abilities of aged muscles.
Telomeres resemble common fragile sites (CFSs) in that they are difficult-to-replicate and exhibit fragility in mitosis in response to DNA replication stress. At CFSs, this fragility is associated with a delay in the completion of DNA r... | Treatment with a protein named FN restores regenerative abilities of aged muscles.
Telomeres resemble common fragile sites (CFSs) in that they are difficult-to-replicate and exhibit fragility in mitosis in response to DNA replication stress. At CFSs, this fragility is associated with a delay in the completion of DNA r... | 0.4 | {
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In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.
Tight regulation of the expression of mRNAs encoding iron uptake proteins is essential to control iron homeostasis and avoid intracellular iron toxicity. We show that many mRNAs encoding iron uptake or iron mobiliza... | In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.
Tight regulation of the expression of mRNAs encoding iron uptake proteins is essential to control iron homeostasis and avoid intracellular iron toxicity. We show that many mRNAs encoding iron uptake or iron mobiliza... | 1 | {
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Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.
Multicellular animals rapidly clear dying cells from their bodies. Many of the pathways that mediate this cell removal are conserved through evolution. Here, we identify srgp-1 as a negative regulator of cell clear... | Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.
Multicellular animals rapidly clear dying cells from their bodies. Many of the pathways that mediate this cell removal are conserved through evolution. Here, we identify srgp-1 as a negative regulator of cell clear... | 0 | {
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Cell autonomous sex determination in somatic cells occurs in Galliformes.
CONTEXT In patients with brain metastases, it is unclear whether adding up-front whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) has beneficial effects on mortality or neurologic function compared with SRS alone. OBJECTIV... | Cell autonomous sex determination in somatic cells occurs in Galliformes.
CONTEXT In patients with brain metastases, it is unclear whether adding up-front whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) has beneficial effects on mortality or neurologic function compared with SRS alone. OBJECTIV... | 0 | {
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Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.
CONTEXT Although cerebral palsy (CP) among extremely premature infants has been reported as a major morbidity outcome, there are difficulties comparing published CP rates from many sites over various birth years. OBJECTIVE To assess th... | Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.
CONTEXT Although cerebral palsy (CP) among extremely premature infants has been reported as a major morbidity outcome, there are difficulties comparing published CP rates from many sites over various birth years. OBJECTIVE To assess th... | 0 | {
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Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)
CONTEXT Whether immunosuppressive treatment adversely affects survival is unclear. OBJECTIVE To assess whether immunosuppressive drugs increase mortality. DESIGN Retrospective cohort ... | Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)
CONTEXT Whether immunosuppressive treatment adversely affects survival is unclear. OBJECTIVE To assess whether immunosuppressive drugs increase mortality. DESIGN Retrospective cohort ... | 0.5 | {
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Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.
&NA; Immune cells communicate by exchanging cytokines to achieve a context‐appropriate response, but the distances over which such communication happens are not known. Here, w... | Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.
&NA; Immune cells communicate by exchanging cytokines to achieve a context‐appropriate response, but the distances over which such communication happens are not known. Here, w... | 0 | {
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TNFAIP3 is a glioblastoma tumor enhancer.
Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the bulk tumor that may be useful therapeutic targets. We determined that A20 (TNFAI... | TNFAIP3 is a glioblastoma tumor enhancer.
Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the bulk tumor that may be useful therapeutic targets. We determined that A20 (TNFAI... | 1 | {
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Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.
It is becoming “a truth universally acknowledged” that the education of undergraduate medical students will be enhanced through the use of computer assisted learning. Access to the wide range of ... | Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.
It is becoming “a truth universally acknowledged” that the education of undergraduate medical students will be enhanced through the use of computer assisted learning. Access to the wide range of ... | 1 | {
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During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.
Humoral immune responses depend on B cells encountering antigen, interacting with helper T cells, proliferating and differentiating into low-affin... | During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.
Humoral immune responses depend on B cells encountering antigen, interacting with helper T cells, proliferating and differentiating into low-affin... | 1 | {
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Mutations in RIM1 raise levels of IME1 RNA.
Improved sequencing technologies offer unprecedented opportunities for investigating the role of rare genetic variation in common disease. However, there are considerable challenges with respect to study design, data analysis and replication. Using pooled next-generation seq... | Mutations in RIM1 raise levels of IME1 RNA.
Improved sequencing technologies offer unprecedented opportunities for investigating the role of rare genetic variation in common disease. However, there are considerable challenges with respect to study design, data analysis and replication. Using pooled next-generation seq... | 0 | {
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There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.
BACKGROUND The annual number of hospital admissions and in-hospital deaths due to severe acute lower respiratory infections (ALRI) in young children worldwide is unknown. We aimed to estimate the incidence of admissions and death... | There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.
BACKGROUND The annual number of hospital admissions and in-hospital deaths due to severe acute lower respiratory infections (ALRI) in young children worldwide is unknown. We aimed to estimate the incidence of admissions and death... | 1 | {
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The proliferative capacity of progenitors is regulated cell-autonomously.
Organisms are constantly challenged by stresses and privations and require adaptive responses for their survival. The forkhead box O (FOXO) transcription factor DAF-16 (hereafter referred to as DAF-16/FOXO) is a central nexus in these responses,... | The proliferative capacity of progenitors is regulated cell-autonomously.
Organisms are constantly challenged by stresses and privations and require adaptive responses for their survival. The forkhead box O (FOXO) transcription factor DAF-16 (hereafter referred to as DAF-16/FOXO) is a central nexus in these responses,... | 0.333333 | {
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Immune responses in immune cells are geographically segregated.
Acute lymphoblastic leukemia (ALL) is an aggressive hematological tumor resulting from the malignant transformation of lymphoid progenitors. Despite intensive chemotherapy, 20% of pediatric patients and over 50% of adult patients with ALL do not achieve a... | Immune responses in immune cells are geographically segregated.
Acute lymphoblastic leukemia (ALL) is an aggressive hematological tumor resulting from the malignant transformation of lymphoid progenitors. Despite intensive chemotherapy, 20% of pediatric patients and over 50% of adult patients with ALL do not achieve a... | 0.333333 | {
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Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.
IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. OBJECTIVE To determine efficacy and safety of varenicline ... | Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.
IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. OBJECTIVE To determine efficacy and safety of varenicline ... | 1 | {
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p16INK4A degradation is encoded by CDKN2A.
Background The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymerase, connection, and ribonuclease H (RNase H) domains. Almost all known RT inhibitor resistance mutations identified to date... | p16INK4A degradation is encoded by CDKN2A.
Background The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymerase, connection, and ribonuclease H (RNase H) domains. Almost all known RT inhibitor resistance mutations identified to date... | 0.4 | {
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Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.
Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. We have previously identified iron-responsive element-binding protein 2 (IRP2) as an important COPD susceptibility gene and have show... | Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.
Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. We have previously identified iron-responsive element-binding protein 2 (IRP2) as an important COPD susceptibility gene and have show... | 1 | {
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Lack of FGF21 in mice leads to atherosclerotic plaque formation.
The forkhead O (FoxO) family of transcription factors participates in diverse physiologic processes, including induction of cell-cycle arrest, stress resistance, differentiation, apoptosis, and metabolism. Several recent studies indicate that FoxO-depend... | Lack of FGF21 in mice leads to atherosclerotic plaque formation.
The forkhead O (FoxO) family of transcription factors participates in diverse physiologic processes, including induction of cell-cycle arrest, stress resistance, differentiation, apoptosis, and metabolism. Several recent studies indicate that FoxO-depend... | 0.333333 | {
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F4/80+ macrophages regulate mature osteoblast maintenance.
OBJECTIVE To determine the effectiveness and cost effectiveness of using information from circulating biomarkers to inform the prioritisation process of patients with stable angina awaiting coronary artery bypass graft surgery. DESIGN Decision analytical model... | F4/80+ macrophages regulate mature osteoblast maintenance.
OBJECTIVE To determine the effectiveness and cost effectiveness of using information from circulating biomarkers to inform the prioritisation process of patients with stable angina awaiting coronary artery bypass graft surgery. DESIGN Decision analytical model... | 0 | {
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In pediatric tissue, most T cells are naive T cell emigrants from the thymus.
Dynamically polarized membrane proteins define different cell boundaries and have an important role in intercellular communication—a vital feature of multicellular development. Efflux carriers for the signalling molecule auxin from the PIN f... | In pediatric tissue, most T cells are naive T cell emigrants from the thymus.
Dynamically polarized membrane proteins define different cell boundaries and have an important role in intercellular communication—a vital feature of multicellular development. Efflux carriers for the signalling molecule auxin from the PIN f... | 0.285714 | {
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Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.
Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control to prevent uncontrolled inflammation. Herein, we identify the Kruppel-like transcripti... | Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.
Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control to prevent uncontrolled inflammation. Herein, we identify the Kruppel-like transcripti... | 0 | {
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Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.
Inflammasomes are multiprotein complexes that include members of the NLR (nucleotide-binding domain leucine-rich repeat containing) family and caspase-1. Once bacterial molecules are sensed within ... | Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.
Inflammasomes are multiprotein complexes that include members of the NLR (nucleotide-binding domain leucine-rich repeat containing) family and caspase-1. Once bacterial molecules are sensed within ... | 0.333333 | {
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Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.
&NA; Immune cells communicate by exchanging cytokines to achieve a context‐appropriate response, but the distances over which such communication happens are not known. Here, w... | Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.
&NA; Immune cells communicate by exchanging cytokines to achieve a context‐appropriate response, but the distances over which such communication happens are not known. Here, w... | 0 | {
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"gener... | 980 | aug_184 |
Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.
Experience gained from the Global Malaria Eradication Program (1955-72) identified a set of shared technical and operational factors that enabled some countries to successfully eliminate malaria. Spatial data for these... | Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.
Experience gained from the Global Malaria Eradication Program (1955-72) identified a set of shared technical and operational factors that enabled some countries to successfully eliminate malaria. Spatial data for these... | 0 | {
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"original_query_id": "896",
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"1710116",
"32275758",
"16999023",
"18949516",
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"generation_version": "1.0.0",
"gener... | 896 | aug_185 |
Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.
Embryonic stem cells have the ability to remain undifferentiated and proliferate indefinitely in vitro while maintaining the potential to differentiate into derivatives of all three embryonic germ layers. These cells have, therefore, potential for in ... | Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.
Embryonic stem cells have the ability to remain undifferentiated and proliferate indefinitely in vitro while maintaining the potential to differentiate into derivatives of all three embryonic germ layers. These cells have, therefore, potential for in ... | 0.4 | {
"query_id": "1027",
"original_query_id": "1027",
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"18956141",
"36651210",
"3113630",
"13868795"
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"context_f1": 0.4,
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"generation_ti... | 1027 | aug_186 |
Lack of FGF21 in mice leads to reduced lifespan.
Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interactions between tumor growth/m... | Lack of FGF21 in mice leads to reduced lifespan.
Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interactions between tumor growth/m... | 0.5 | {
"query_id": "682",
"original_query_id": "682",
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"14075252",
"306006",
"9315213"
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"9315213"
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"context_f1": 0.5,
"context_size": 3,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-2... | 682 | aug_187 |
Bariatric surgery reduces postmenopausal breast cancer.
Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease. LRRK2 is a multifunctional protein affecting many cellular processes and has been described to bind microtubules. Defective microtubule-based axonal transport... | Bariatric surgery reduces postmenopausal breast cancer.
Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease. LRRK2 is a multifunctional protein affecting many cellular processes and has been described to bind microtubules. Defective microtubule-based axonal transport... | 0.333333 | {
"query_id": "169",
"original_query_id": "169",
"context_doc_ids": [
"10009203",
"9638032",
"4373433",
"5824985",
"12643937"
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"5824985"
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"context_f1": 0.33333333333333337,
"context_size": 5,
"generation_version... | 169 | aug_188 |
The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.
CONTEXT Blood type and crossmatch incompatibility will exclude at least one third of patients in need from receiving a live donor kidney transplant.... | The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.
CONTEXT Blood type and crossmatch incompatibility will exclude at least one third of patients in need from receiving a live donor kidney transplant.... | 0.4 | {
"query_id": "1184",
"original_query_id": "1184",
"context_doc_ids": [
"16737210",
"25254425",
"8582337",
"4926049"
],
"gold_doc_ids_in_context": [
"16737210"
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"total_gold_docs_for_query": 1,
"context_f1": 0.4,
"context_size": 4,
"generation_version": "1.0.0",
"generation_ti... | 1184 | aug_189 |
1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.
Apart from HIV two exogenous retroviruses (human T cell leukaemia viruses type I (HTLV-I) and type II (HTLV-II)) infect humans. HTLV-I infection is endemic in Japan, the Caribbean, Africa, and Melanesia and is found among immigrants ... | 1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.
Apart from HIV two exogenous retroviruses (human T cell leukaemia viruses type I (HTLV-I) and type II (HTLV-II)) infect humans. HTLV-I infection is endemic in Japan, the Caribbean, Africa, and Melanesia and is found among immigrants ... | 0 | {
"query_id": "4",
"original_query_id": "4",
"context_doc_ids": [
"21387297",
"2014909",
"16390264",
"34071621",
"641786",
"24512064"
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"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"generati... | 4 | aug_190 |
Pharmacist attendance at ward rounds reduces adverse events in wards.
Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops. Although chromos... | Pharmacist attendance at ward rounds reduces adverse events in wards.
Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops. Although chromos... | 0 | {
"query_id": "941",
"original_query_id": "941",
"context_doc_ids": [
"30507607",
"14637235",
"15058155",
"418246",
"12580014",
"23351136"
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"generation_version": "1.0.0",
"gen... | 941 | aug_191 |
The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.
The cytosolic helicase retinoic acid-inducible gene-I (RIG-I) initiates immune responses to most RNA viruses by detecting viral 5'-triphosphorylated RNA (pppRNA). Although endogenous mRNA is also 5'-triphosphorylated, b... | The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.
The cytosolic helicase retinoic acid-inducible gene-I (RIG-I) initiates immune responses to most RNA viruses by detecting viral 5'-triphosphorylated RNA (pppRNA). Although endogenous mRNA is also 5'-triphosphorylated, b... | 0.5 | {
"query_id": "1193",
"original_query_id": "1193",
"context_doc_ids": [
"24221369",
"20532591",
"791050"
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"gold_doc_ids_in_context": [
"20532591"
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"total_gold_docs_for_query": 1,
"context_f1": 0.5,
"context_size": 3,
"generation_version": "1.0.0",
"generation_timestamp": "2025-... | 1193 | aug_192 |
Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.
The TLX1 and TLX3 transcription factor oncogenes have a key role in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL). Here we used reverse engineering of global transcriptional networks to dec... | Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.
The TLX1 and TLX3 transcription factor oncogenes have a key role in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL). Here we used reverse engineering of global transcriptional networks to dec... | 0.285714 | {
"query_id": "854",
"original_query_id": "854",
"context_doc_ids": [
"12206390",
"1797622",
"19912367",
"1982286",
"16999023",
"19313533"
],
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"12206390"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.2857142857142857,
"context_size": 6,
"g... | 854 | aug_193 |
The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.
CONTEXT Blood type and crossmatch incompatibility will exclude at least one third of patients in need from receiving a live donor kidney transplant.... | The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.
CONTEXT Blood type and crossmatch incompatibility will exclude at least one third of patients in need from receiving a live donor kidney transplant.... | 0.4 | {
"query_id": "1184",
"original_query_id": "1184",
"context_doc_ids": [
"16737210",
"25254425",
"8582337",
"4926049"
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"gold_doc_ids_in_context": [
"16737210"
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"total_gold_docs_for_query": 1,
"context_f1": 0.4,
"context_size": 4,
"generation_version": "1.0.0",
"generation_ti... | 1184 | aug_194 |
Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.
Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controversial results owing to the use of unreliable methods for clearly identifyin... | Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.
Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controversial results owing to the use of unreliable methods for clearly identifyin... | 1 | {
"query_id": "689",
"original_query_id": "689",
"context_doc_ids": [
"22080671"
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"22080671"
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"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.242568",
"dataset... | 689 | aug_195 |
Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.
The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein antigens (ACPAs) i... | Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.
The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein antigens (ACPAs) i... | 0.5 | {
"query_id": "264",
"original_query_id": "264",
"context_doc_ids": [
"24384587",
"3874000",
"11328820"
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"11328820"
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"total_gold_docs_for_query": 1,
"context_f1": 0.5,
"context_size": 3,
"generation_version": "1.0.0",
"generation_timestamp": "2025-0... | 264 | aug_196 |
Antimicrobial agents are more effective due to the pressure of antimicrobial usage.
Overusing antibiotics is not the only cause and reducing use is not the only solution W arning signs of antimicrobial resistance, chinks in the antimicrobial armour, began to appear in the middle of the last century, and by the 1990s... | Antimicrobial agents are more effective due to the pressure of antimicrobial usage.
Overusing antibiotics is not the only cause and reducing use is not the only solution W arning signs of antimicrobial resistance, chinks in the antimicrobial armour, began to appear in the middle of the last century, and by the 1990s... | 1 | {
"query_id": "122",
"original_query_id": "122",
"context_doc_ids": [
"31460499"
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"31460499"
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"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.242675",
"dataset... | 122 | aug_197 |
Monoclonal antibody targeting of N-cadherin encourages metastasis.
Biological systems use a variety of mechanisms to maintain their functions in the face of environmental and genetic perturbations. Increasing evidence suggests that, among their roles as posttranscriptional repressors of gene expression, microRNAs (miR... | Monoclonal antibody targeting of N-cadherin encourages metastasis.
Biological systems use a variety of mechanisms to maintain their functions in the face of environmental and genetic perturbations. Increasing evidence suggests that, among their roles as posttranscriptional repressors of gene expression, microRNAs (miR... | 0.285714 | {
"query_id": "802",
"original_query_id": "802",
"context_doc_ids": [
"22180793",
"24221369",
"14658685",
"2565138",
"28617573",
"12440953"
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"22180793"
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"total_gold_docs_for_query": 1,
"context_f1": 0.2857142857142857,
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"... | 802 | aug_198 |
p16INK4A degradation is encoded by CDKN2A.
Background The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymerase, connection, and ribonuclease H (RNase H) domains. Almost all known RT inhibitor resistance mutations identified to date... | p16INK4A degradation is encoded by CDKN2A.
Background The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymerase, connection, and ribonuclease H (RNase H) domains. Almost all known RT inhibitor resistance mutations identified to date... | 0.4 | {
"query_id": "1398",
"original_query_id": "1398",
"context_doc_ids": [
"18956141",
"17844478",
"17717391",
"15319019"
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"gold_doc_ids_in_context": [
"17717391"
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"context_f1": 0.4,
"context_size": 4,
"generation_version": "1.0.0",
"generation_... | 1398 | aug_199 |
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