query stringclasses 184
values | texts stringclasses 184
values | label float64 0 1 | metadata dict | query_id stringclasses 184
values | id stringlengths 7 7 ⌀ |
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Treatment with a protein named FN impairs regenerative abilities of aged muscles.
Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation. Association of the RNA-binding protein HuR with... | Treatment with a protein named FN impairs regenerative abilities of aged muscles.
Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation. Association of the RNA-binding protein HuR with... | 0.333333 | {
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Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.
Little is known about the inter-individual variation of cytokine responses to different pathogens in healthy individuals. To systematically describe cytokine responses elicited by distinct pathogens and to determine the effect ... | Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.
Little is known about the inter-individual variation of cytokine responses to different pathogens in healthy individuals. To systematically describe cytokine responses elicited by distinct pathogens and to determine the effect ... | 1 | {
"query_id": "976",
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"dataset":... | 976 | aug_901 |
A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.
Blind individuals often demonstrate enhanced nonvisual perceptual abilities. However, the neural substrate that underlies this improved performance remains to be fully understood. An earlier behavioral study demonstrat... | A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.
Blind individuals often demonstrate enhanced nonvisual perceptual abilities. However, the neural substrate that underlies this improved performance remains to be fully understood. An earlier behavioral study demonstrat... | 0 | {
"query_id": "46",
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Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.
Age-related changes in the niche have long been postulated to impair the function of somatic stem cells. Here we demonstrate that the aged stem cell niche in skeletal muscle contains substantially reduced levels of fibronectin (FN),... | Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.
Age-related changes in the niche have long been postulated to impair the function of somatic stem cells. Here we demonstrate that the aged stem cell niche in skeletal muscle contains substantially reduced levels of fibronectin (FN),... | 0.5 | {
"query_id": "606",
"original_query_id": "606",
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"generation_timestamp": "2025-07-24... | 606 | aug_903 |
Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.
Little is known about the inter-individual variation of cytokine responses to different pathogens in healthy individuals. To systematically describe cytokine responses elicited by distinct pathogens and to determine the effect ... | Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.
Little is known about the inter-individual variation of cytokine responses to different pathogens in healthy individuals. To systematically describe cytokine responses elicited by distinct pathogens and to determine the effect ... | 1 | {
"query_id": "976",
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"generation_timestamp": "2025-07-24T12:04:39.287389",
"dataset":... | 976 | aug_904 |
Normal granulomas form in the presence of TNF in Zebrafish.
Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert protection by directing formation of granulomas, organized aggregates of macrophages and other immune cells. Loss of TNF signaling causes progression of tuberculosis ... | Normal granulomas form in the presence of TNF in Zebrafish.
Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert protection by directing formation of granulomas, organized aggregates of macrophages and other immune cells. Loss of TNF signaling causes progression of tuberculosis ... | 1 | {
"query_id": "861",
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"generation_timestamp": "2025-07-24T12:04:39.287404",
"dataset... | 861 | aug_905 |
Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.
BACKGROUND Histone deimination regulates gene function and contributes to antimicrobial response, allowing the formation of neutrophil extracellular traps (NETs). Deiminated proteins are target of anti-citrullinated peptides ... | Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.
BACKGROUND Histone deimination regulates gene function and contributes to antimicrobial response, allowing the formation of neutrophil extracellular traps (NETs). Deiminated proteins are target of anti-citrullinated peptides ... | 0 | {
"query_id": "670",
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"gener... | 670 | aug_906 |
CHOP is a general endoplasmic reticulum stress marker.
Over the past two decades there have been significant achievements in the control of a handful of important human tropical infections [1]. These achievements include the substantive reductions in the prevalence and incidence of the so-called neglected diseases suc... | CHOP is a general endoplasmic reticulum stress marker.
Over the past two decades there have been significant achievements in the control of a handful of important human tropical infections [1]. These achievements include the substantive reductions in the prevalence and incidence of the so-called neglected diseases suc... | 0.333333 | {
"query_id": "209",
"original_query_id": "209",
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"generation_versio... | 209 | aug_907 |
Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)
CONTEXT Whether immunosuppressive treatment adversely affects survival is unclear. OBJECTIVE To assess whether immunosuppressive drugs increase mortality. DESIGN Retrospective cohort ... | Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)
CONTEXT Whether immunosuppressive treatment adversely affects survival is unclear. OBJECTIVE To assess whether immunosuppressive drugs increase mortality. DESIGN Retrospective cohort ... | 0.5 | {
"query_id": "1125",
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"4455466"
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"generation_timestamp": "2025-... | 1125 | aug_908 |
Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.
In single-stranded ribonucleic acid (RNA) viruses, virus capsid assembly and genome packaging are intertwined processes. Using cryo-electron microscopy and single particle analysis we determin... | Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.
In single-stranded ribonucleic acid (RNA) viruses, virus capsid assembly and genome packaging are intertwined processes. Using cryo-electron microscopy and single particle analysis we determin... | 0 | {
"query_id": "621",
"original_query_id": "621",
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"gene... | 621 | aug_909 |
GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.
Maintaining hematopoietic stem cell (HSC) quiescence is a critical property for the life-long generation of blood cells. Approximately 75% of cells in a highly enriched long-term repopulating HSC (LT-HSC) pool (Lin(-)Sca1(+)c-Kit(hi)CD150(+... | GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.
Maintaining hematopoietic stem cell (HSC) quiescence is a critical property for the life-long generation of blood cells. Approximately 75% of cells in a highly enriched long-term repopulating HSC (LT-HSC) pool (Lin(-)Sca1(+)c-Kit(hi)CD150(+... | 1 | {
"query_id": "445",
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"generation_timestamp": "2025-07-24T12:04:39.287685",
"dataset... | 445 | aug_910 |
DUSP4 increases apoptosis.
Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However, many patients have residual cancer after chemotherapy, which correlates with a higher risk of metastatic recurrence and poorer outcome than those who achieve a pCR. ... | DUSP4 increases apoptosis.
Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However, many patients have residual cancer after chemotherapy, which correlates with a higher risk of metastatic recurrence and poorer outcome than those who achieve a pCR. ... | 0.4 | {
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"generation_timest... | 309 | aug_911 |
Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.
The TLX1 and TLX3 transcription factor oncogenes have a key role in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL). Here we used reverse engineering of global transcriptional networks to dec... | Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.
The TLX1 and TLX3 transcription factor oncogenes have a key role in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL). Here we used reverse engineering of global transcriptional networks to dec... | 0.285714 | {
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"g... | 854 | aug_912 |
DRD1 proteins enable Pol V transcription in vivo.
Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete IL-1β independently of classical inflammasome stimuli. Here, we report that this constituted a sp... | DRD1 proteins enable Pol V transcription in vivo.
Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete IL-1β independently of classical inflammasome stimuli. Here, we report that this constituted a sp... | 0 | {
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"gene... | 305 | aug_913 |
miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.
Nanotechnologies are emerging platforms that could be useful in measuring, understanding, and manipulating stem cells. Examples include magnetic nanoparticles and quantum dots for stem cell labeling and in vivo tracking; nanoparticles, carbon... | miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.
Nanotechnologies are emerging platforms that could be useful in measuring, understanding, and manipulating stem cells. Examples include magnetic nanoparticles and quantum dots for stem cell labeling and in vivo tracking; nanoparticles, carbon... | 0 | {
"query_id": "1393",
"original_query_id": "1393",
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"generation_version": "1.0.0",
"g... | 1393 | aug_914 |
Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.
Animal host defense against infection requires the expression of defense genes at the right place and the right time. Understanding such tight control of host defense requires the elucidation... | Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.
Animal host defense against infection requires the expression of defense genes at the right place and the right time. Understanding such tight control of host defense requires the elucidation... | 0.5 | {
"query_id": "1312",
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"generation_timestamp": "2025-... | 1312 | aug_915 |
Expression of oncolytic virus antigens as peptides makes relapse more likely.
To identify previously unknown platelet receptors we compared the transcriptomes of in vitro differentiated megakaryocytes (MKs) and erythroblasts (EBs). RNA was obtained from purified, biologically paired MK and EB cultures and compared usi... | Expression of oncolytic virus antigens as peptides makes relapse more likely.
To identify previously unknown platelet receptors we compared the transcriptomes of in vitro differentiated megakaryocytes (MKs) and erythroblasts (EBs). RNA was obtained from purified, biologically paired MK and EB cultures and compared usi... | 0.333333 | {
"query_id": "403",
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"generation_versi... | 403 | aug_916 |
The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.
Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cellular level of the disease are currently not available. H... | The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.
Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cellular level of the disease are currently not available. H... | 0.333333 | {
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"generation_ve... | 1215 | aug_917 |
Mouse models can be generated using "artificial spermatids."
Haploid cells are amenable for genetic analysis. Recent success in the derivation of mouse haploid embryonic stem cells (haESCs) via parthenogenesis has enabled genetic screening in mammalian cells. However, successful generation of live animals from these h... | Mouse models can be generated using "artificial spermatids."
Haploid cells are amenable for genetic analysis. Recent success in the derivation of mouse haploid embryonic stem cells (haESCs) via parthenogenesis has enabled genetic screening in mammalian cells. However, successful generation of live animals from these h... | 1 | {
"query_id": "810",
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"generation_timestamp": "2025-07-24T12:04:39.288188",
"dataset... | 810 | aug_918 |
General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.
OBJECTIVE To measure whether the benefits of a single education and self management structured programme for people with newly diagnosed type 2 diabetes mellitus are sustained at three... | General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.
OBJECTIVE To measure whether the benefits of a single education and self management structured programme for people with newly diagnosed type 2 diabetes mellitus are sustained at three... | 0.4 | {
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"generation_times... | 454 | aug_919 |
The risk of female prisoners harming themselves is ten times that of male prisoners.
BACKGROUND Self-harm and suicide are common in prisoners, yet robust information on the full extent and characteristics of people at risk of self-harm is scant. Furthermore, understanding how frequently self-harm is followed by suicid... | The risk of female prisoners harming themselves is ten times that of male prisoners.
BACKGROUND Self-harm and suicide are common in prisoners, yet robust information on the full extent and characteristics of people at risk of self-harm is scant. Furthermore, understanding how frequently self-harm is followed by suicid... | 1 | {
"query_id": "1269",
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"generation_timestamp": "2025-07-24T12:04:39.288278",
"datas... | 1269 | aug_920 |
Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.
Circadian cycles and cell cycles are two fundamental periodic processes with a period in the range of 1 day. Consequently, coupling between such cycles can lead ... | Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.
Circadian cycles and cell cycles are two fundamental periodic processes with a period in the range of 1 day. Consequently, coupling between such cycles can lead ... | 0 | {
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"gene... | 927 | aug_921 |
PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.
Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult tissue macrophages originate during embryonic development and not... | PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.
Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult tissue macrophages originate during embryonic development and not... | 0.4 | {
"query_id": "969",
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"generation_timestamp": "2025-... | 969 | aug_922 |
PCSK9 inhibitors decrease plasma Lp(a) levels.
BACKGROUND Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (apoB). Although studies in mice and cells have identified increased hepatic LDL receptor... | PCSK9 inhibitors decrease plasma Lp(a) levels.
BACKGROUND Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (apoB). Although studies in mice and cells have identified increased hepatic LDL receptor... | 1 | {
"query_id": "901",
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"generation_timestamp": "2025-07-24T12:04:39.288437",
"dataset":... | 901 | aug_923 |
Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.
It is becoming “a truth universally acknowledged” that the education of undergraduate medical students will be enhanced through the use of computer assisted learning. Access to the wide range of ... | Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.
It is becoming “a truth universally acknowledged” that the education of undergraduate medical students will be enhanced through the use of computer assisted learning. Access to the wide range of ... | 1 | {
"query_id": "650",
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"dataset... | 650 | aug_924 |
Low nucleosome occupancy correlates with high methylation levels across species.
Dnmt1 epigenetically propagates symmetrical CG methylation in many eukaryotes. Their genomes are typically depleted of CG dinucleotides because of imperfect repair of deaminated methylcytosines. Here, we extensively survey diverse species... | Low nucleosome occupancy correlates with high methylation levels across species.
Dnmt1 epigenetically propagates symmetrical CG methylation in many eukaryotes. Their genomes are typically depleted of CG dinucleotides because of imperfect repair of deaminated methylcytosines. Here, we extensively survey diverse species... | 1 | {
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"dataset... | 717 | aug_925 |
Lack of FGF21 in mice leads to reduced lifespan.
Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interactions between tumor growth/m... | Lack of FGF21 in mice leads to reduced lifespan.
Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interactions between tumor growth/m... | 0.5 | {
"query_id": "682",
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"generation_timestamp": "2025-07-2... | 682 | aug_926 |
PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.
Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult tissue macrophages originate during embryonic development and not... | PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.
Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult tissue macrophages originate during embryonic development and not... | 0.4 | {
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"generation_timestamp": "2025-... | 969 | aug_927 |
Low nucleosome occupancy correlates with high methylation levels across species.
Dnmt1 epigenetically propagates symmetrical CG methylation in many eukaryotes. Their genomes are typically depleted of CG dinucleotides because of imperfect repair of deaminated methylcytosines. Here, we extensively survey diverse species... | Low nucleosome occupancy correlates with high methylation levels across species.
Dnmt1 epigenetically propagates symmetrical CG methylation in many eukaryotes. Their genomes are typically depleted of CG dinucleotides because of imperfect repair of deaminated methylcytosines. Here, we extensively survey diverse species... | 1 | {
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"dataset... | 717 | aug_928 |
Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.
BACKGROUND Patients with familial amyloid polyneuropathy, a rare hereditary form of amyloidosis, have progressive autonomic neuropathy. The disease usually does not induce heart failure but is associated with sud... | Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.
BACKGROUND Patients with familial amyloid polyneuropathy, a rare hereditary form of amyloidosis, have progressive autonomic neuropathy. The disease usually does not induce heart failure but is associated with sud... | 1 | {
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"dataset... | 1112 | aug_929 |
DUSP4 downregulation deactivates the Ras-ERK pathway
BMP is thought to induce hESC differentiation toward multiple lineages including mesoderm and trophoblast. The BMP-induced trophoblast phenotype is a long-standing paradox in stem cell biology. Here we readdressed BMP function in hESCs and mouse epiblast-derived cel... | DUSP4 downregulation deactivates the Ras-ERK pathway
BMP is thought to induce hESC differentiation toward multiple lineages including mesoderm and trophoblast. The BMP-induced trophoblast phenotype is a long-standing paradox in stem cell biology. Here we readdressed BMP function in hESCs and mouse epiblast-derived cel... | 0.4 | {
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"generation_timest... | 308 | aug_930 |
miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.
Nanotechnologies are emerging platforms that could be useful in measuring, understanding, and manipulating stem cells. Examples include magnetic nanoparticles and quantum dots for stem cell labeling and in vivo tracking; nanoparticles, carbon... | miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.
Nanotechnologies are emerging platforms that could be useful in measuring, understanding, and manipulating stem cells. Examples include magnetic nanoparticles and quantum dots for stem cell labeling and in vivo tracking; nanoparticles, carbon... | 0 | {
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"g... | 1393 | aug_931 |
PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.
Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1-independent thermogenic mechanism in beige fat that invo... | PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.
Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1-independent thermogenic mechanism in beige fat that invo... | 0.333333 | {
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"generation_vers... | 916 | aug_932 |
Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.
In single-stranded ribonucleic acid (RNA) viruses, virus capsid assembly and genome packaging are intertwined processes. Using cryo-electron microscopy and single particle analysis we determin... | Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.
In single-stranded ribonucleic acid (RNA) viruses, virus capsid assembly and genome packaging are intertwined processes. Using cryo-electron microscopy and single particle analysis we determin... | 0 | {
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"gene... | 621 | aug_933 |
Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.
Cancer stem cells drive tumor formation and metastasis, but how they acquire metastatic traits is not well understood. Here, we show that all colorectal cancer stem cells (CR-CSCs) exp... | Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.
Cancer stem cells drive tumor formation and metastasis, but how they acquire metastatic traits is not well understood. Here, we show that all colorectal cancer stem cells (CR-CSCs) exp... | 0.333333 | {
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Malaria has a high vectorial capacity.
Experience gained from the Global Malaria Eradication Program (1955-72) identified a set of shared technical and operational factors that enabled some countries to successfully eliminate malaria. Spatial data for these factors were assembled for all malaria-endemic countries and ... | Malaria has a high vectorial capacity.
Experience gained from the Global Malaria Eradication Program (1955-72) identified a set of shared technical and operational factors that enabled some countries to successfully eliminate malaria. Spatial data for these factors were assembled for all malaria-endemic countries and ... | 1 | {
"query_id": "753",
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"dataset":... | 753 | aug_935 |
Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.
Blood monocytes are well-characterized precursors for macrophages and dendritic cells. Subsets of human monocytes with differential representation in various disease states are well known. In contrast, mouse monocyte ... | Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.
Blood monocytes are well-characterized precursors for macrophages and dendritic cells. Subsets of human monocytes with differential representation in various disease states are well known. In contrast, mouse monocyte ... | 0 | {
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A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).
In systemic lupus erythematosus (SLE), self-reactive antibodies can target the kidney (lupus nephritis), leading to functional failure and possible mortality. We report that activation of basophils by a... | A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).
In systemic lupus erythematosus (SLE), self-reactive antibodies can target the kidney (lupus nephritis), leading to functional failure and possible mortality. We report that activation of basophils by a... | 1 | {
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Side effects associated with antidepressants increases risk of stroke.
Alzheimer's disease is the most common neurodegenerative disease, and there are no mechanism-based therapies. The disease is defined by the presence of abundant neurofibrillary lesions and neuritic plaques in the cerebral cortex. Neurofibrillary le... | Side effects associated with antidepressants increases risk of stroke.
Alzheimer's disease is the most common neurodegenerative disease, and there are no mechanism-based therapies. The disease is defined by the presence of abundant neurofibrillary lesions and neuritic plaques in the cerebral cortex. Neurofibrillary le... | 0.285714 | {
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"gen... | 1084 | aug_938 |
Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.
BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urba... | Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.
BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urba... | 1 | {
"query_id": "337",
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"dataset":... | 337 | aug_939 |
Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.
In this study, we used whole-genome sequencing and gene expression profiling of 215 human induced pluripotent stem cell (iPSC) lines from different donors to identify genetic variants associated with RNA expression for 5,746 gen... | Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.
In this study, we used whole-genome sequencing and gene expression profiling of 215 human induced pluripotent stem cell (iPSC) lines from different donors to identify genetic variants associated with RNA expression for 5,746 gen... | 0 | {
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"genera... | 123 | aug_940 |
Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.
Calorie restriction slows aging and increases life span in many organisms. In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2. Here we report the... | Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.
Calorie restriction slows aging and increases life span in many organisms. In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2. Here we report the... | 0 | {
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"gener... | 112 | aug_941 |
Anthrax spores remain deadly until affected areas are decontaminated.
CONTEXT Bioterrorist attacks involving letters and mail-handling systems in Washington, DC, resulted in Bacillus anthracis (anthrax) spore contamination in the Hart Senate Office Building and other facilities in the US Capitol's vicinity. OBJECTIVE ... | Anthrax spores remain deadly until affected areas are decontaminated.
CONTEXT Bioterrorist attacks involving letters and mail-handling systems in Washington, DC, resulted in Bacillus anthracis (anthrax) spore contamination in the Hart Senate Office Building and other facilities in the US Capitol's vicinity. OBJECTIVE ... | 1 | {
"query_id": "116",
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"dataset... | 116 | aug_942 |
Mutations in RIM1 raise levels of IME1 RNA.
Improved sequencing technologies offer unprecedented opportunities for investigating the role of rare genetic variation in common disease. However, there are considerable challenges with respect to study design, data analysis and replication. Using pooled next-generation seq... | Mutations in RIM1 raise levels of IME1 RNA.
Improved sequencing technologies offer unprecedented opportunities for investigating the role of rare genetic variation in common disease. However, there are considerable challenges with respect to study design, data analysis and replication. Using pooled next-generation seq... | 0 | {
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"gener... | 816 | aug_943 |
A deficiency of vitamin B6 decreases blood levels of homocysteine.
OBJECTIVE To establish the mental health needs of homeless children and families before and after rehousing. DESIGN Cross sectional, longitudinal study. SETTING City of Birmingham. SUBJECTS 58 rehoused families with 103 children aged 2-16 years and 21 ... | A deficiency of vitamin B6 decreases blood levels of homocysteine.
OBJECTIVE To establish the mental health needs of homeless children and families before and after rehousing. DESIGN Cross sectional, longitudinal study. SETTING City of Birmingham. SUBJECTS 58 rehoused families with 103 children aged 2-16 years and 21 ... | 0 | {
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The innate immune response struggles to remove small numbers of parasites.
Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops. Although ch... | The innate immune response struggles to remove small numbers of parasites.
Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops. Although ch... | 0.285714 | {
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Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.
Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. We have previously identified iron-responsive element-binding protein 2 (IRP2) as an important COPD susceptibility gene and have show... | Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.
Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. We have previously identified iron-responsive element-binding protein 2 (IRP2) as an important COPD susceptibility gene and have show... | 1 | {
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"dataset":... | 301 | aug_946 |
Progerin induces premature aging in stem cells.
Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation. Association of the RNA-binding protein HuR with lincRNA-p21 favored the recruitme... | Progerin induces premature aging in stem cells.
Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation. Association of the RNA-binding protein HuR with lincRNA-p21 favored the recruitme... | 0 | {
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"ge... | 979 | aug_947 |
A deficiency of vitamin B6 decreases blood levels of homocysteine.
OBJECTIVE To establish the mental health needs of homeless children and families before and after rehousing. DESIGN Cross sectional, longitudinal study. SETTING City of Birmingham. SUBJECTS 58 rehoused families with 103 children aged 2-16 years and 21 ... | A deficiency of vitamin B6 decreases blood levels of homocysteine.
OBJECTIVE To establish the mental health needs of homeless children and families before and after rehousing. DESIGN Cross sectional, longitudinal study. SETTING City of Birmingham. SUBJECTS 58 rehoused families with 103 children aged 2-16 years and 21 ... | 0 | {
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"genera... | 37 | aug_948 |
The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.
Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in the pathogenesis of infla... | The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.
Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in the pathogenesis of infla... | 1 | {
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"datas... | 1171 | aug_949 |
Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)
CONTEXT Whether immunosuppressive treatment adversely affects survival is unclear. OBJECTIVE To assess whether immunosuppressive drugs increase mortality. DESIGN Retrospective cohort ... | Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)
CONTEXT Whether immunosuppressive treatment adversely affects survival is unclear. OBJECTIVE To assess whether immunosuppressive drugs increase mortality. DESIGN Retrospective cohort ... | 0.5 | {
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In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.
BACKGROUND Although cigarette smoking, excessive alcohol drinking, obesity, and several other well-studied unhealthy lifestyle-related factors each have been linked to the risk of multiple chronic diseases and premat... | In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.
BACKGROUND Although cigarette smoking, excessive alcohol drinking, obesity, and several other well-studied unhealthy lifestyle-related factors each have been linked to the risk of multiple chronic diseases and premat... | 0 | {
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"genera... | 565 | aug_951 |
The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.
The cytosolic helicase retinoic acid-inducible gene-I (RIG-I) initiates immune responses to most RNA viruses by detecting viral 5'-triphosphorylated RNA (pppRNA). Although endogenous mRNA is also 5'-triphosphorylated, b... | The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.
The cytosolic helicase retinoic acid-inducible gene-I (RIG-I) initiates immune responses to most RNA viruses by detecting viral 5'-triphosphorylated RNA (pppRNA). Although endogenous mRNA is also 5'-triphosphorylated, b... | 0.5 | {
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"generation_timestamp": "2025-... | 1193 | aug_952 |
Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.
In single-stranded ribonucleic acid (RNA) viruses, virus capsid assembly and genome packaging are intertwined processes. Using cryo-electron microscopy and single particle analysis we determin... | Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.
In single-stranded ribonucleic acid (RNA) viruses, virus capsid assembly and genome packaging are intertwined processes. Using cryo-electron microscopy and single particle analysis we determin... | 0 | {
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"gene... | 621 | aug_953 |
B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.
Plants have evolved a tremendous ability to respond to environmental changes by adapting their growth and development. The interaction between hormonal and developmental ... | B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.
Plants have evolved a tremendous ability to respond to environmental changes by adapting their growth and development. The interaction between hormonal and developmental ... | 0 | {
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"gener... | 153 | aug_954 |
Hypothalamic glutamate neurotransmission is unrelated to energy balance.
The importance of neuropeptides in the hypothalamus has been experimentally established. Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters glutamate and GABA are largely unknown. Synaptic vesicular ... | Hypothalamic glutamate neurotransmission is unrelated to energy balance.
The importance of neuropeptides in the hypothalamus has been experimentally established. Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters glutamate and GABA are largely unknown. Synaptic vesicular ... | 1 | {
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... | 541 | aug_955 |
Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.
Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cellular level of the disease are currently not availab... | Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.
Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cellular level of the disease are currently not availab... | 1 | {
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"dataset... | 626 | aug_956 |
Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.
Cancer stem cells drive tumor formation and metastasis, but how they acquire metastatic traits is not well understood. Here, we show that all colorectal cancer stem cells (CR-CSCs) exp... | Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.
Cancer stem cells drive tumor formation and metastasis, but how they acquire metastatic traits is not well understood. Here, we show that all colorectal cancer stem cells (CR-CSCs) exp... | 0.333333 | {
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Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.
Combinatorial transcription factor (TF) interactions control cellular phenotypes and, therefore, underpin stem cell formation, maintenance, and differentiation. Here, we report the genome-wide bin... | Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.
Combinatorial transcription factor (TF) interactions control cellular phenotypes and, therefore, underpin stem cell formation, maintenance, and differentiation. Here, we report the genome-wide bin... | 0 | {
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Mouse models can be generated using "artificial spermatids."
Haploid cells are amenable for genetic analysis. Recent success in the derivation of mouse haploid embryonic stem cells (haESCs) via parthenogenesis has enabled genetic screening in mammalian cells. However, successful generation of live animals from these h... | Mouse models can be generated using "artificial spermatids."
Haploid cells are amenable for genetic analysis. Recent success in the derivation of mouse haploid embryonic stem cells (haESCs) via parthenogenesis has enabled genetic screening in mammalian cells. However, successful generation of live animals from these h... | 1 | {
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"dataset... | 810 | aug_959 |
Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media.
The organization of cells, emerging from cell-cell interactions, can give rise to collective properties. These properties are adaptive when together cells can face environ... | Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media.
The organization of cells, emerging from cell-cell interactions, can give rise to collective properties. These properties are adaptive when together cells can face environ... | 1 | {
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Immune complex triggered cell death leads to extracellular release of nuclear DNA.
We compared conscious and nonconscious processing of briefly flashed words using a visual masking procedure while recording intracranial electroencephalogram (iEEG) in ten patients. Nonconscious processing of masked words was observed i... | Immune complex triggered cell death leads to extracellular release of nuclear DNA.
We compared conscious and nonconscious processing of briefly flashed words using a visual masking procedure while recording intracranial electroencephalogram (iEEG) in ten patients. Nonconscious processing of masked words was observed i... | 0 | {
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The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.
The oncogenic BCR/ABL tyrosine kinase induces constitutive DNA damage in Philadelphia chromosome (Ph)-positive leukemia cells. We find that BCR/ABL-induced reactive oxygen species (ROSs) cause chroni... | The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.
The oncogenic BCR/ABL tyrosine kinase induces constitutive DNA damage in Philadelphia chromosome (Ph)-positive leukemia cells. We find that BCR/ABL-induced reactive oxygen species (ROSs) cause chroni... | 0.333333 | {
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GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.
Maintaining hematopoietic stem cell (HSC) quiescence is a critical property for the life-long generation of blood cells. Approximately 75% of cells in a highly enriched long-term repopulating HSC (LT-HSC) pool (Lin(-)Sca1(+)c-Kit(hi)CD150(+... | GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.
Maintaining hematopoietic stem cell (HSC) quiescence is a critical property for the life-long generation of blood cells. Approximately 75% of cells in a highly enriched long-term repopulating HSC (LT-HSC) pool (Lin(-)Sca1(+)c-Kit(hi)CD150(+... | 1 | {
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"dataset... | 445 | aug_963 |
Cell autonomous sex determination in somatic cells occurs in Galliformes.
CONTEXT In patients with brain metastases, it is unclear whether adding up-front whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) has beneficial effects on mortality or neurologic function compared with SRS alone. OBJECTIV... | Cell autonomous sex determination in somatic cells occurs in Galliformes.
CONTEXT In patients with brain metastases, it is unclear whether adding up-front whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) has beneficial effects on mortality or neurologic function compared with SRS alone. OBJECTIV... | 0 | {
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A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.
Blind individuals often demonstrate enhanced nonvisual perceptual abilities. However, the neural substrate that underlies this improved performance remains to be fully understood. An earlier behavioral study demonstrat... | A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.
Blind individuals often demonstrate enhanced nonvisual perceptual abilities. However, the neural substrate that underlies this improved performance remains to be fully understood. An earlier behavioral study demonstrat... | 0 | {
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"generat... | 46 | aug_965 |
DRD1 proteins enable Pol V transcription in vivo.
Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete IL-1β independently of classical inflammasome stimuli. Here, we report that this constituted a sp... | DRD1 proteins enable Pol V transcription in vivo.
Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete IL-1β independently of classical inflammasome stimuli. Here, we report that this constituted a sp... | 0 | {
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"gene... | 305 | aug_966 |
Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.
It is becoming “a truth universally acknowledged” that the education of undergraduate medical students will be enhanced through the use of computer assisted learning. Access to the wide range of ... | Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.
It is becoming “a truth universally acknowledged” that the education of undergraduate medical students will be enhanced through the use of computer assisted learning. Access to the wide range of ... | 1 | {
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"dataset... | 650 | aug_967 |
Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.
The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary th... | Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.
The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary th... | 0.285714 | {
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Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.
Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controversial results owing to the use of unreliable methods for clearly identifyin... | Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.
Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controversial results owing to the use of unreliable methods for clearly identifyin... | 1 | {
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"dataset... | 689 | aug_969 |
Low nucleosome occupancy correlates with high methylation levels across species.
Dnmt1 epigenetically propagates symmetrical CG methylation in many eukaryotes. Their genomes are typically depleted of CG dinucleotides because of imperfect repair of deaminated methylcytosines. Here, we extensively survey diverse species... | Low nucleosome occupancy correlates with high methylation levels across species.
Dnmt1 epigenetically propagates symmetrical CG methylation in many eukaryotes. Their genomes are typically depleted of CG dinucleotides because of imperfect repair of deaminated methylcytosines. Here, we extensively survey diverse species... | 1 | {
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"dataset... | 717 | aug_970 |
Lack of FGF21 in mice increases life expectancy.
Interleukin-18 (IL18) participates in atherogenesis through several putative mechanisms. Interruption of IL18 action reduces atherosclerosis in mice. Here, we show that absence of the IL18 receptor (IL18r) does not affect atherosclerosis in apolipoprotein E–deficient (A... | Lack of FGF21 in mice increases life expectancy.
Interleukin-18 (IL18) participates in atherogenesis through several putative mechanisms. Interruption of IL18 action reduces atherosclerosis in mice. Here, we show that absence of the IL18 receptor (IL18r) does not affect atherosclerosis in apolipoprotein E–deficient (A... | 0.4 | {
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"generation_times... | 680 | aug_971 |
Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.
Despite growing interest and a recent surge in papers, the role of autophagy in glucose and lipid metabolism is unclear. We produced mice with skeletal muscle–specific deletion of Atg7 (encoding ... | Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.
Despite growing interest and a recent surge in papers, the role of autophagy in glucose and lipid metabolism is unclear. We produced mice with skeletal muscle–specific deletion of Atg7 (encoding ... | 0.333333 | {
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A deficiency of vitamin B6 decreases blood levels of homocysteine.
OBJECTIVE To establish the mental health needs of homeless children and families before and after rehousing. DESIGN Cross sectional, longitudinal study. SETTING City of Birmingham. SUBJECTS 58 rehoused families with 103 children aged 2-16 years and 21 ... | A deficiency of vitamin B6 decreases blood levels of homocysteine.
OBJECTIVE To establish the mental health needs of homeless children and families before and after rehousing. DESIGN Cross sectional, longitudinal study. SETTING City of Birmingham. SUBJECTS 58 rehoused families with 103 children aged 2-16 years and 21 ... | 0 | {
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"genera... | 37 | aug_973 |
GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.
RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing. Using an in vitro transcription/splicing assay, we demonstrate that an association of ... | GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.
RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing. Using an in vitro transcription/splicing assay, we demonstrate that an association of ... | 0.333333 | {
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"generation_vers... | 444 | aug_974 |
p16INK4A degradation is encoded by CDKN2A.
Background The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymerase, connection, and ribonuclease H (RNase H) domains. Almost all known RT inhibitor resistance mutations identified to date... | p16INK4A degradation is encoded by CDKN2A.
Background The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymerase, connection, and ribonuclease H (RNase H) domains. Almost all known RT inhibitor resistance mutations identified to date... | 0.4 | {
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"generation_... | 1398 | aug_975 |
Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.
Embryonic stem (ES) cell lines derived from human blastocysts have the developmental potential to form derivatives of all three embryonic germ layers even after prolonged culture. Here... | Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.
Embryonic stem (ES) cell lines derived from human blastocysts have the developmental potential to form derivatives of all three embryonic germ layers even after prolonged culture. Here... | 0.285714 | {
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... | 531 | aug_976 |
Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.
IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. OBJECTIVE To determine efficacy and safety of varenicline ... | Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.
IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. OBJECTIVE To determine efficacy and safety of varenicline ... | 0.5 | {
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"generation_timestamp": "2025-... | 272 | aug_977 |
The innate immune response struggles to remove small numbers of parasites.
Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops. Although ch... | The innate immune response struggles to remove small numbers of parasites.
Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops. Although ch... | 0.285714 | {
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Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.
Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with recipro... | Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.
Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with recipro... | 0.4 | {
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"generation_... | 1330 | aug_979 |
Peroxynitrite is required for induction of T cell tolerance.
Antigen-specific CD8+ T-cell tolerance, induced by myeloid-derived suppressor cells (MDSCs), is one of the main mechanisms of tumor escape. Using in vivo models, we show here that MDSCs directly disrupt the binding of specific peptide–major histocompatibilit... | Peroxynitrite is required for induction of T cell tolerance.
Antigen-specific CD8+ T-cell tolerance, induced by myeloid-derived suppressor cells (MDSCs), is one of the main mechanisms of tumor escape. Using in vivo models, we show here that MDSCs directly disrupt the binding of specific peptide–major histocompatibilit... | 0.5 | {
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A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.
CONTEXT Diagnostic lumbar punctures (LPs), commonly used to rule out meningitis, are associated with adverse events. OBJECTIVE To systematically review the evidence about diagnostic LP techniques that may ... | A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.
CONTEXT Diagnostic lumbar punctures (LPs), commonly used to rule out meningitis, are associated with adverse events. OBJECTIVE To systematically review the evidence about diagnostic LP techniques that may ... | 0 | {
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"genera... | 41 | aug_981 |
Urbanization is an important risk factor related to the transmission of dengue fever.
Characterization of human monoclonal antibodies is providing considerable insight into mechanisms of broad HIV-1 neutralization. Here we report an HIV-1 gp41 membrane-proximal external region (MPER)-specific antibody, named 10E8, whi... | Urbanization is an important risk factor related to the transmission of dengue fever.
Characterization of human monoclonal antibodies is providing considerable insight into mechanisms of broad HIV-1 neutralization. Here we report an HIV-1 gp41 membrane-proximal external region (MPER)-specific antibody, named 10E8, whi... | 0.5 | {
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"generation_timestamp": "2025... | 1353 | aug_982 |
A deficiency of vitamin B6 decreases blood levels of homocysteine.
OBJECTIVE To establish the mental health needs of homeless children and families before and after rehousing. DESIGN Cross sectional, longitudinal study. SETTING City of Birmingham. SUBJECTS 58 rehoused families with 103 children aged 2-16 years and 21 ... | A deficiency of vitamin B6 decreases blood levels of homocysteine.
OBJECTIVE To establish the mental health needs of homeless children and families before and after rehousing. DESIGN Cross sectional, longitudinal study. SETTING City of Birmingham. SUBJECTS 58 rehoused families with 103 children aged 2-16 years and 21 ... | 0 | {
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"genera... | 37 | aug_983 |
DRD1 proteins enable Pol V transcription in vivo.
Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete IL-1β independently of classical inflammasome stimuli. Here, we report that this constituted a sp... | DRD1 proteins enable Pol V transcription in vivo.
Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete IL-1β independently of classical inflammasome stimuli. Here, we report that this constituted a sp... | 0 | {
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"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"gene... | 305 | aug_984 |
MeCP2 influences the synaptic maturation of neurons.
BACKGROUND Although unstable coronary artery disease is the most common reason for admission to a coronary care unit, the long-term prognosis of patients with this diagnosis is unknown. This is particularly true for patients with diabetes mellitus, who are known to ... | MeCP2 influences the synaptic maturation of neurons.
BACKGROUND Although unstable coronary artery disease is the most common reason for admission to a coronary care unit, the long-term prognosis of patients with this diagnosis is unknown. This is particularly true for patients with diabetes mellitus, who are known to ... | 0.333333 | {
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"5884524",
"13901073",
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"generation_versi... | 761 | aug_985 |
ART has no effect on the infectiveness of HIV-positive people.
Amitriptyline is the medication of first choice in the treatment of chronic tension-type headache. In 197 patients with chronic tension-type headache (87M and 110F with a mean age of 38 +/- 13 (18-68)) efficacy and tolerability of 60-90 mg amitriptylinoxid... | ART has no effect on the infectiveness of HIV-positive people.
Amitriptyline is the medication of first choice in the treatment of chronic tension-type headache. In 197 patients with chronic tension-type headache (87M and 110F with a mean age of 38 +/- 13 (18-68)) efficacy and tolerability of 60-90 mg amitriptylinoxid... | 0 | {
"query_id": "60",
"original_query_id": "60",
"context_doc_ids": [
"2692522",
"4427392",
"2565138",
"23865182",
"3701541",
"19313533"
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"total_gold_docs_for_query": 2,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"generat... | 60 | aug_986 |
In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.
BACKGROUND Although cigarette smoking, excessive alcohol drinking, obesity, and several other well-studied unhealthy lifestyle-related factors each have been linked to the risk of multiple chronic diseases and premat... | In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.
BACKGROUND Although cigarette smoking, excessive alcohol drinking, obesity, and several other well-studied unhealthy lifestyle-related factors each have been linked to the risk of multiple chronic diseases and premat... | 0 | {
"query_id": "565",
"original_query_id": "565",
"context_doc_ids": [
"13400643",
"2890952",
"1456068",
"5289038",
"7185591",
"4394817"
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"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"genera... | 565 | aug_987 |
1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.
Apart from HIV two exogenous retroviruses (human T cell leukaemia viruses type I (HTLV-I) and type II (HTLV-II)) infect humans. HTLV-I infection is endemic in Japan, the Caribbean, Africa, and Melanesia and is found among immigrants ... | 1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.
Apart from HIV two exogenous retroviruses (human T cell leukaemia viruses type I (HTLV-I) and type II (HTLV-II)) infect humans. HTLV-I infection is endemic in Japan, the Caribbean, Africa, and Melanesia and is found among immigrants ... | 0 | {
"query_id": "4",
"original_query_id": "4",
"context_doc_ids": [
"21387297",
"2014909",
"16390264",
"34071621",
"641786",
"24512064"
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"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"generati... | 4 | aug_988 |
Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.
Experience gained from the Global Malaria Eradication Program (1955-72) identified a set of shared technical and operational factors that enabled some countries to successfully eliminate malaria. Spatial data for these... | Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.
Experience gained from the Global Malaria Eradication Program (1955-72) identified a set of shared technical and operational factors that enabled some countries to successfully eliminate malaria. Spatial data for these... | 0 | {
"query_id": "896",
"original_query_id": "896",
"context_doc_ids": [
"1173667",
"1710116",
"32275758",
"16999023",
"18949516",
"306006"
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"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"gener... | 896 | aug_989 |
A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).
In systemic lupus erythematosus (SLE), self-reactive antibodies can target the kidney (lupus nephritis), leading to functional failure and possible mortality. We report that activation of basophils by a... | A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).
In systemic lupus erythematosus (SLE), self-reactive antibodies can target the kidney (lupus nephritis), leading to functional failure and possible mortality. We report that activation of basophils by a... | 1 | {
"query_id": "28",
"original_query_id": "28",
"context_doc_ids": [
"12670680"
],
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"12670680"
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"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.292839",
"dataset":... | 28 | aug_990 |
Urbanization is an important risk factor related to the transmission of dengue fever.
Characterization of human monoclonal antibodies is providing considerable insight into mechanisms of broad HIV-1 neutralization. Here we report an HIV-1 gp41 membrane-proximal external region (MPER)-specific antibody, named 10E8, whi... | Urbanization is an important risk factor related to the transmission of dengue fever.
Characterization of human monoclonal antibodies is providing considerable insight into mechanisms of broad HIV-1 neutralization. Here we report an HIV-1 gp41 membrane-proximal external region (MPER)-specific antibody, named 10E8, whi... | 0.5 | {
"query_id": "1353",
"original_query_id": "1353",
"context_doc_ids": [
"18816720",
"4421578",
"17671145"
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"18816720"
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"context_f1": 0.5,
"context_size": 3,
"generation_version": "1.0.0",
"generation_timestamp": "2025... | 1353 | aug_991 |
DRD1 proteins enable Pol V transcription in vivo.
Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete IL-1β independently of classical inflammasome stimuli. Here, we report that this constituted a sp... | DRD1 proteins enable Pol V transcription in vivo.
Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete IL-1β independently of classical inflammasome stimuli. Here, we report that this constituted a sp... | 0 | {
"query_id": "305",
"original_query_id": "305",
"context_doc_ids": [
"34469966",
"18956141",
"8002887",
"27123743",
"1215116",
"4740447"
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"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"gene... | 305 | aug_992 |
Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.
Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with recipr... | Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.
Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with recipr... | 1 | {
"query_id": "1331",
"original_query_id": "1331",
"context_doc_ids": [
"14075252"
],
"gold_doc_ids_in_context": [
"14075252"
],
"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.293010",
"datas... | 1331 | aug_993 |
Cell autonomous sex determination in somatic cells occurs in Galliformes.
CONTEXT In patients with brain metastases, it is unclear whether adding up-front whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) has beneficial effects on mortality or neurologic function compared with SRS alone. OBJECTIV... | Cell autonomous sex determination in somatic cells occurs in Galliformes.
CONTEXT In patients with brain metastases, it is unclear whether adding up-front whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) has beneficial effects on mortality or neurologic function compared with SRS alone. OBJECTIV... | 0 | {
"query_id": "235",
"original_query_id": "235",
"context_doc_ids": [
"3944632",
"10546779",
"4414547",
"5691302",
"1974176",
"6503185"
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"gold_doc_ids_in_context": [],
"total_gold_docs_for_query": 1,
"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"genera... | 235 | aug_994 |
Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.
Fatty acids are integral mediators of energy storage, membrane formation and cell signaling. The pathways that orchestrate uptake of fatty acids remain incompletely understood. Expression of the integrin ligand Mfge8 is increased in human o... | Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.
Fatty acids are integral mediators of energy storage, membrane formation and cell signaling. The pathways that orchestrate uptake of fatty acids remain incompletely understood. Expression of the integrin ligand Mfge8 is increased in human o... | 0.285714 | {
"query_id": "367",
"original_query_id": "367",
"context_doc_ids": [
"1686997",
"9505448",
"27099731",
"5389095",
"11360768",
"4394817"
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"gold_doc_ids_in_context": [
"27099731"
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"total_gold_docs_for_query": 1,
"context_f1": 0.2857142857142857,
"context_size": 6,
"gen... | 367 | aug_995 |
During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.
Humoral immune responses depend on B cells encountering antigen, interacting with helper T cells, proliferating and differentiating into low-affin... | During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.
Humoral immune responses depend on B cells encountering antigen, interacting with helper T cells, proliferating and differentiating into low-affin... | 1 | {
"query_id": "361",
"original_query_id": "361",
"context_doc_ids": [
"38587347"
],
"gold_doc_ids_in_context": [
"38587347"
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"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.293229",
"dataset... | 361 | aug_996 |
Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.
Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controversial results owing to the use of unreliable methods for clearly identifyin... | Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.
Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controversial results owing to the use of unreliable methods for clearly identifyin... | 1 | {
"query_id": "689",
"original_query_id": "689",
"context_doc_ids": [
"22080671"
],
"gold_doc_ids_in_context": [
"22080671"
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"total_gold_docs_for_query": 1,
"context_f1": 1,
"context_size": 1,
"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.293247",
"dataset... | 689 | aug_997 |
DUSP4 downregulation deactivates the Ras-ERK pathway
BMP is thought to induce hESC differentiation toward multiple lineages including mesoderm and trophoblast. The BMP-induced trophoblast phenotype is a long-standing paradox in stem cell biology. Here we readdressed BMP function in hESCs and mouse epiblast-derived cel... | DUSP4 downregulation deactivates the Ras-ERK pathway
BMP is thought to induce hESC differentiation toward multiple lineages including mesoderm and trophoblast. The BMP-induced trophoblast phenotype is a long-standing paradox in stem cell biology. Here we readdressed BMP function in hESCs and mouse epiblast-derived cel... | 0.4 | {
"query_id": "308",
"original_query_id": "308",
"context_doc_ids": [
"7821634",
"4414481",
"5633876",
"16256507"
],
"gold_doc_ids_in_context": [
"7821634"
],
"total_gold_docs_for_query": 1,
"context_f1": 0.4,
"context_size": 4,
"generation_version": "1.0.0",
"generation_timest... | 308 | aug_998 |
Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.
Blood monocytes are well-characterized precursors for macrophages and dendritic cells. Subsets of human monocytes with differential representation in various disease states are well known. In contrast, mouse monocyte ... | Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.
Blood monocytes are well-characterized precursors for macrophages and dendritic cells. Subsets of human monocytes with differential representation in various disease states are well known. In contrast, mouse monocyte ... | 0 | {
"query_id": "435",
"original_query_id": "435",
"context_doc_ids": [
"1967017",
"4547102",
"4446814",
"9638032",
"36444198",
"9559146"
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"context_f1": 0,
"context_size": 6,
"generation_version": "1.0.0",
"genera... | 435 | aug_999 |
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