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The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.
Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in the pathogenesis of inflamm... | The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.
Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in the pathogenesis of inflamm... | 1 | {
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"generation_timestamp": "2025-07-24T12:04:39.275174",
"datas... | 1170 | aug_700 |
In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.
BACKGROUND In the absence of an effective vaccine, HIV continues to spread globally, emphasizing the need for novel strategies to limit its transmission. Pr... | In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.
BACKGROUND In the absence of an effective vaccine, HIV continues to spread globally, emphasizing the need for novel strategies to limit its transmission. Pr... | 1 | {
"query_id": "582",
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"dataset... | 582 | aug_701 |
Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.
CONTEXT Antibody-based induction therapy plus calcineurin inhibitors (CNIs) reduce acute rejection rates in kidney recipients; however, opportunistic infections and toxic C... | Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.
CONTEXT Antibody-based induction therapy plus calcineurin inhibitors (CNIs) reduce acute rejection rates in kidney recipients; however, opportunistic infections and toxic C... | 1 | {
"query_id": "144",
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"dataset... | 144 | aug_702 |
GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.
RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing. Using an in vitro transcription/splicing assay, we demonstrate that an association of ... | GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.
RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing. Using an in vitro transcription/splicing assay, we demonstrate that an association of ... | 0.333333 | {
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"generation_vers... | 444 | aug_703 |
Low nucleosome occupancy correlates with high methylation levels across species.
Dnmt1 epigenetically propagates symmetrical CG methylation in many eukaryotes. Their genomes are typically depleted of CG dinucleotides because of imperfect repair of deaminated methylcytosines. Here, we extensively survey diverse species... | Low nucleosome occupancy correlates with high methylation levels across species.
Dnmt1 epigenetically propagates symmetrical CG methylation in many eukaryotes. Their genomes are typically depleted of CG dinucleotides because of imperfect repair of deaminated methylcytosines. Here, we extensively survey diverse species... | 1 | {
"query_id": "717",
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"dataset... | 717 | aug_704 |
HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).
BACKGROUND The large-scale emigration of physicians from sub-Saharan Africa (SSA) to high-income nations is a serious development concern. Our objective was to determine current emigration trends of SSA physicians foun... | HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).
BACKGROUND The large-scale emigration of physicians from sub-Saharan Africa (SSA) to high-income nations is a serious development concern. Our objective was to determine current emigration trends of SSA physicians foun... | 0 | {
"query_id": "499",
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"g... | 499 | aug_705 |
Myelin sheaths play a role in action potential propagation.
BACKGROUND Information is scarce about the combined effects on breast cancer incidence of low-penetrance genetic susceptibility polymorphisms and environmental factors (reproductive, behavioural, and anthropometric risk factors for breast cancer). To test for... | Myelin sheaths play a role in action potential propagation.
BACKGROUND Information is scarce about the combined effects on breast cancer incidence of low-penetrance genetic susceptibility polymorphisms and environmental factors (reproductive, behavioural, and anthropometric risk factors for breast cancer). To test for... | 0 | {
"query_id": "818",
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"gen... | 818 | aug_706 |
Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.
In single-stranded ribonucleic acid (RNA) viruses, virus capsid assembly and genome packaging are intertwined processes. Using cryo-electron microscopy and single particle analysis we determin... | Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.
In single-stranded ribonucleic acid (RNA) viruses, virus capsid assembly and genome packaging are intertwined processes. Using cryo-electron microscopy and single particle analysis we determin... | 0 | {
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"gene... | 621 | aug_707 |
Lack of FGF21 in mice leads to atherosclerotic plaque formation.
The forkhead O (FoxO) family of transcription factors participates in diverse physiologic processes, including induction of cell-cycle arrest, stress resistance, differentiation, apoptosis, and metabolism. Several recent studies indicate that FoxO-depend... | Lack of FGF21 in mice leads to atherosclerotic plaque formation.
The forkhead O (FoxO) family of transcription factors participates in diverse physiologic processes, including induction of cell-cycle arrest, stress resistance, differentiation, apoptosis, and metabolism. Several recent studies indicate that FoxO-depend... | 0.333333 | {
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Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.
It is becoming “a truth universally acknowledged” that the education of undergraduate medical students will be enhanced through the use of computer assisted learning. Access to the wide range of ... | Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.
It is becoming “a truth universally acknowledged” that the education of undergraduate medical students will be enhanced through the use of computer assisted learning. Access to the wide range of ... | 1 | {
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"dataset... | 650 | aug_709 |
Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.
Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation. Ass... | Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.
Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation. Ass... | 0 | {
"query_id": "1028",
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"gen... | 1028 | aug_710 |
Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.
It is becoming “a truth universally acknowledged” that the education of undergraduate medical students will be enhanced through the use of computer assisted learning. Access to the wide range of ... | Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.
It is becoming “a truth universally acknowledged” that the education of undergraduate medical students will be enhanced through the use of computer assisted learning. Access to the wide range of ... | 1 | {
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"dataset... | 650 | aug_711 |
Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.
Despite growing interest and a recent surge in papers, the role of autophagy in glucose and lipid metabolism is unclear. We produced mice with skeletal muscle–specific deletion of Atg7 (encoding ... | Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.
Despite growing interest and a recent surge in papers, the role of autophagy in glucose and lipid metabolism is unclear. We produced mice with skeletal muscle–specific deletion of Atg7 (encoding ... | 0.333333 | {
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ART has no effect on the infectiveness of HIV-positive people.
Amitriptyline is the medication of first choice in the treatment of chronic tension-type headache. In 197 patients with chronic tension-type headache (87M and 110F with a mean age of 38 +/- 13 (18-68)) efficacy and tolerability of 60-90 mg amitriptylinoxid... | ART has no effect on the infectiveness of HIV-positive people.
Amitriptyline is the medication of first choice in the treatment of chronic tension-type headache. In 197 patients with chronic tension-type headache (87M and 110F with a mean age of 38 +/- 13 (18-68)) efficacy and tolerability of 60-90 mg amitriptylinoxid... | 0 | {
"query_id": "60",
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"generat... | 60 | aug_713 |
Polymeal nutrition increases cardiovascular mortality.
Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes. Wolfram syndrome 1 (WFS1) has been shown to be an important regulator of the ER stress signalling pathway; however, its ro... | Polymeal nutrition increases cardiovascular mortality.
Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes. Wolfram syndrome 1 (WFS1) has been shown to be an important regulator of the ER stress signalling pathway; however, its ro... | 0.4 | {
"query_id": "959",
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"generation_version": "1.0.0",
"generation_times... | 959 | aug_714 |
Lack of FGF21 in mice leads to atherosclerotic plaque formation.
The forkhead O (FoxO) family of transcription factors participates in diverse physiologic processes, including induction of cell-cycle arrest, stress resistance, differentiation, apoptosis, and metabolism. Several recent studies indicate that FoxO-depend... | Lack of FGF21 in mice leads to atherosclerotic plaque formation.
The forkhead O (FoxO) family of transcription factors participates in diverse physiologic processes, including induction of cell-cycle arrest, stress resistance, differentiation, apoptosis, and metabolism. Several recent studies indicate that FoxO-depend... | 0.333333 | {
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"generation_versio... | 681 | aug_715 |
In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.
BACKGROUND In the absence of an effective vaccine, HIV continues to spread globally, emphasizing the need for novel strategies to limit its transmission. Pr... | In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.
BACKGROUND In the absence of an effective vaccine, HIV continues to spread globally, emphasizing the need for novel strategies to limit its transmission. Pr... | 1 | {
"query_id": "582",
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"dataset... | 582 | aug_716 |
Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.
Calorie restriction slows aging and increases life span in many organisms. In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2. Here we report the... | Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.
Calorie restriction slows aging and increases life span in many organisms. In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2. Here we report the... | 0 | {
"query_id": "112",
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"gener... | 112 | aug_717 |
A deficiency of vitamin B6 decreases blood levels of homocysteine.
OBJECTIVE To establish the mental health needs of homeless children and families before and after rehousing. DESIGN Cross sectional, longitudinal study. SETTING City of Birmingham. SUBJECTS 58 rehoused families with 103 children aged 2-16 years and 21 ... | A deficiency of vitamin B6 decreases blood levels of homocysteine.
OBJECTIVE To establish the mental health needs of homeless children and families before and after rehousing. DESIGN Cross sectional, longitudinal study. SETTING City of Birmingham. SUBJECTS 58 rehoused families with 103 children aged 2-16 years and 21 ... | 0 | {
"query_id": "37",
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"genera... | 37 | aug_718 |
Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.
Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. We have previously identified iron-responsive element-binding protein 2 (IRP2) as an important COPD susceptibility gene and have show... | Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.
Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. We have previously identified iron-responsive element-binding protein 2 (IRP2) as an important COPD susceptibility gene and have show... | 1 | {
"query_id": "301",
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"generation_timestamp": "2025-07-24T12:04:39.276605",
"dataset":... | 301 | aug_719 |
The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.
The functional heart is comprised of distinct mesoderm-derived lineages including cardiomyocytes, endothelial cells and vascular smooth muscle cells. Studies in the mouse embryo and the mouse embryonic stem cell ... | The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.
The functional heart is comprised of distinct mesoderm-derived lineages including cardiomyocytes, endothelial cells and vascular smooth muscle cells. Studies in the mouse embryo and the mouse embryonic stem cell ... | 1 | {
"query_id": "1239",
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"generation_timestamp": "2025-07... | 1239 | aug_720 |
EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.
Genome-wide association studies are now identifying disease-associated chromosome regions. However, even after convincing replication, the localization of the causal variant(s) requires comprehensive resequen... | EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.
Genome-wide association studies are now identifying disease-associated chromosome regions. However, even after convincing replication, the localization of the causal variant(s) requires comprehensive resequen... | 0.5 | {
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"generation_timestamp": "2025-07-... | 363 | aug_721 |
Cell autonomous sex determination in somatic cells occurs in Galliformes.
CONTEXT In patients with brain metastases, it is unclear whether adding up-front whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) has beneficial effects on mortality or neurologic function compared with SRS alone. OBJECTIV... | Cell autonomous sex determination in somatic cells occurs in Galliformes.
CONTEXT In patients with brain metastases, it is unclear whether adding up-front whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) has beneficial effects on mortality or neurologic function compared with SRS alone. OBJECTIV... | 0 | {
"query_id": "235",
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"genera... | 235 | aug_722 |
Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.
Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control to prevent uncontrolled inflammation. Herein, we identify the Kruppel-like transcripti... | Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.
Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control to prevent uncontrolled inflammation. Herein, we identify the Kruppel-like transcripti... | 0 | {
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"generation_version": "1.0.0",
"gen... | 607 | aug_723 |
Rising temperatures caused by global warming increases risk of dengue fever transmission.
BACKGROUND Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors related to the human host, virus, mosquito vect... | Rising temperatures caused by global warming increases risk of dengue fever transmission.
BACKGROUND Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors related to the human host, virus, mosquito vect... | 0.285714 | {
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... | 1052 | aug_724 |
Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility.
CONTEXT Chronic tension-type headaches are characterized by near-daily headaches and often are difficult to manage in primary practice. Behavioral and pharmacological therapies each appear modestly effec... | Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility.
CONTEXT Chronic tension-type headaches are characterized by near-daily headaches and often are difficult to manage in primary practice. Behavioral and pharmacological therapies each appear modestly effec... | 0 | {
"query_id": "1325",
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"generation_version": "1.0.0",
"ge... | 1325 | aug_725 |
Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media.
The organization of cells, emerging from cell-cell interactions, can give rise to collective properties. These properties are adaptive when together cells can face environ... | Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media.
The organization of cells, emerging from cell-cell interactions, can give rise to collective properties. These properties are adaptive when together cells can face environ... | 1 | {
"query_id": "1114",
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"generation_timestamp": "2025-07-24T12:04:39.277115",
"datas... | 1114 | aug_726 |
p16INK4A degradation is encoded by CDKN2A.
Background The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymerase, connection, and ribonuclease H (RNase H) domains. Almost all known RT inhibitor resistance mutations identified to date... | p16INK4A degradation is encoded by CDKN2A.
Background The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymerase, connection, and ribonuclease H (RNase H) domains. Almost all known RT inhibitor resistance mutations identified to date... | 0.4 | {
"query_id": "1398",
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"generation_... | 1398 | aug_727 |
Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.
Blood monocytes are well-characterized precursors for macrophages and dendritic cells. Subsets of human monocytes with differential representation in various disease states are well known. In contrast, mouse monocyte ... | Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.
Blood monocytes are well-characterized precursors for macrophages and dendritic cells. Subsets of human monocytes with differential representation in various disease states are well known. In contrast, mouse monocyte ... | 0 | {
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Satellite cell dysfunction is a key factor in sarcopenia development.
A key determinant of geriatric frailty is sarcopenia, the age-associated loss of skeletal muscle mass and strength. Although the etiology of sarcopenia is unknown, the correlation during aging between the loss of activity of satellite cells, which a... | Satellite cell dysfunction is a key factor in sarcopenia development.
A key determinant of geriatric frailty is sarcopenia, the age-associated loss of skeletal muscle mass and strength. Although the etiology of sarcopenia is unknown, the correlation during aging between the loss of activity of satellite cells, which a... | 1 | {
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General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.
OBJECTIVE To measure whether the benefits of a single education and self management structured programme for people with newly diagnosed type 2 diabetes mellitus are sustained at three... | General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.
OBJECTIVE To measure whether the benefits of a single education and self management structured programme for people with newly diagnosed type 2 diabetes mellitus are sustained at three... | 0.4 | {
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"generation_times... | 454 | aug_730 |
CHOP is a general endoplasmic reticulum stress marker.
Over the past two decades there have been significant achievements in the control of a handful of important human tropical infections [1]. These achievements include the substantive reductions in the prevalence and incidence of the so-called neglected diseases suc... | CHOP is a general endoplasmic reticulum stress marker.
Over the past two decades there have been significant achievements in the control of a handful of important human tropical infections [1]. These achievements include the substantive reductions in the prevalence and incidence of the so-called neglected diseases suc... | 0.333333 | {
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In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.
BACKGROUND In the absence of an effective vaccine, HIV continues to spread globally, emphasizing the need for novel strategies to limit its transmission. Pr... | In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.
BACKGROUND In the absence of an effective vaccine, HIV continues to spread globally, emphasizing the need for novel strategies to limit its transmission. Pr... | 1 | {
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Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.
During fasting, mammals maintain normal glucose homeostasis by stimulating hepatic gluconeogenesis. Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic glucone... | Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.
During fasting, mammals maintain normal glucose homeostasis by stimulating hepatic gluconeogenesis. Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic glucone... | 1 | {
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Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.
Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control to prevent uncontrolled inflammation. Herein, we identify the Kruppel-like transcripti... | Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.
Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control to prevent uncontrolled inflammation. Herein, we identify the Kruppel-like transcripti... | 0 | {
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Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.
Cancer stem cells drive tumor formation and metastasis, but how they acquire metastatic traits is not well understood. Here, we show that all colorectal cancer stem cells (CR-CSCs) exp... | Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.
Cancer stem cells drive tumor formation and metastasis, but how they acquire metastatic traits is not well understood. Here, we show that all colorectal cancer stem cells (CR-CSCs) exp... | 0.333333 | {
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Aggravated inflammation is dependent on NLRP3 inflammasome activation.
Development of the acute and chronic inflammatory responses known as gout and pseudogout are associated with the deposition of monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals, respectively, in joints and periarticular tiss... | Aggravated inflammation is dependent on NLRP3 inflammasome activation.
Development of the acute and chronic inflammatory responses known as gout and pseudogout are associated with the deposition of monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals, respectively, in joints and periarticular tiss... | 1 | {
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Treatment with a protein named FN restores regenerative abilities of aged muscles.
Telomeres resemble common fragile sites (CFSs) in that they are difficult-to-replicate and exhibit fragility in mitosis in response to DNA replication stress. At CFSs, this fragility is associated with a delay in the completion of DNA r... | Treatment with a protein named FN restores regenerative abilities of aged muscles.
Telomeres resemble common fragile sites (CFSs) in that they are difficult-to-replicate and exhibit fragility in mitosis in response to DNA replication stress. At CFSs, this fragility is associated with a delay in the completion of DNA r... | 0.4 | {
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"generation_ti... | 1324 | aug_737 |
ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.
Haploid cells are amenable for genetic analysis. Recent success in the derivation of mouse haploid embryonic stem cells (haESCs) via parthenogenesis has enabled genetic screening in mammalian cells. However, successful generation of... | ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.
Haploid cells are amenable for genetic analysis. Recent success in the derivation of mouse haploid embryonic stem cells (haESCs) via parthenogenesis has enabled genetic screening in mammalian cells. However, successful generation of... | 0.4 | {
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"generation_time... | 52 | aug_738 |
Peroxynitrite is required for induction of T cell tolerance.
Antigen-specific CD8+ T-cell tolerance, induced by myeloid-derived suppressor cells (MDSCs), is one of the main mechanisms of tumor escape. Using in vivo models, we show here that MDSCs directly disrupt the binding of specific peptide–major histocompatibilit... | Peroxynitrite is required for induction of T cell tolerance.
Antigen-specific CD8+ T-cell tolerance, induced by myeloid-derived suppressor cells (MDSCs), is one of the main mechanisms of tumor escape. Using in vivo models, we show here that MDSCs directly disrupt the binding of specific peptide–major histocompatibilit... | 0.5 | {
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"generation_timestamp": "2025-07-... | 935 | aug_739 |
Side effects associated with antidepressants increases risk of stroke.
Alzheimer's disease is the most common neurodegenerative disease, and there are no mechanism-based therapies. The disease is defined by the presence of abundant neurofibrillary lesions and neuritic plaques in the cerebral cortex. Neurofibrillary le... | Side effects associated with antidepressants increases risk of stroke.
Alzheimer's disease is the most common neurodegenerative disease, and there are no mechanism-based therapies. The disease is defined by the presence of abundant neurofibrillary lesions and neuritic plaques in the cerebral cortex. Neurofibrillary le... | 0.285714 | {
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Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.
Little is known about the inter-individual variation of cytokine responses to different pathogens in healthy individuals. To systematically describe cytokine responses elicited by distinct pathogens and to determine the effect ... | Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.
Little is known about the inter-individual variation of cytokine responses to different pathogens in healthy individuals. To systematically describe cytokine responses elicited by distinct pathogens and to determine the effect ... | 1 | {
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Lack of FGF21 in mice leads to atherosclerotic plaque formation.
The forkhead O (FoxO) family of transcription factors participates in diverse physiologic processes, including induction of cell-cycle arrest, stress resistance, differentiation, apoptosis, and metabolism. Several recent studies indicate that FoxO-depend... | Lack of FGF21 in mice leads to atherosclerotic plaque formation.
The forkhead O (FoxO) family of transcription factors participates in diverse physiologic processes, including induction of cell-cycle arrest, stress resistance, differentiation, apoptosis, and metabolism. Several recent studies indicate that FoxO-depend... | 0.333333 | {
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"generation_versio... | 681 | aug_742 |
Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.
Fatty acids are integral mediators of energy storage, membrane formation and cell signaling. The pathways that orchestrate uptake of fatty acids remain incompletely understood. Expression of the integrin ligand Mfge8 is increased in human o... | Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.
Fatty acids are integral mediators of energy storage, membrane formation and cell signaling. The pathways that orchestrate uptake of fatty acids remain incompletely understood. Expression of the integrin ligand Mfge8 is increased in human o... | 0.285714 | {
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The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.
CONTEXT Blood type and crossmatch incompatibility will exclude at least one third of patients in need from receiving a live donor kidney transplant.... | The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.
CONTEXT Blood type and crossmatch incompatibility will exclude at least one third of patients in need from receiving a live donor kidney transplant.... | 0.4 | {
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Polymeal nutrition increases cardiovascular mortality.
Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes. Wolfram syndrome 1 (WFS1) has been shown to be an important regulator of the ER stress signalling pathway; however, its ro... | Polymeal nutrition increases cardiovascular mortality.
Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes. Wolfram syndrome 1 (WFS1) has been shown to be an important regulator of the ER stress signalling pathway; however, its ro... | 0.4 | {
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"generation_times... | 959 | aug_745 |
Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.
BACKGROUND Patients with familial amyloid polyneuropathy, a rare hereditary form of amyloidosis, have progressive autonomic neuropathy. The disease usually does not induce heart failure but is associated with sud... | Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.
BACKGROUND Patients with familial amyloid polyneuropathy, a rare hereditary form of amyloidosis, have progressive autonomic neuropathy. The disease usually does not induce heart failure but is associated with sud... | 1 | {
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PCSK9 inhibitors decrease plasma Lp(a) levels.
BACKGROUND Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (apoB). Although studies in mice and cells have identified increased hepatic LDL receptor... | PCSK9 inhibitors decrease plasma Lp(a) levels.
BACKGROUND Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (apoB). Although studies in mice and cells have identified increased hepatic LDL receptor... | 1 | {
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"dataset":... | 901 | aug_747 |
Normal granulomas form in the presence of TNF in Zebrafish.
Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert protection by directing formation of granulomas, organized aggregates of macrophages and other immune cells. Loss of TNF signaling causes progression of tuberculosis ... | Normal granulomas form in the presence of TNF in Zebrafish.
Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert protection by directing formation of granulomas, organized aggregates of macrophages and other immune cells. Loss of TNF signaling causes progression of tuberculosis ... | 1 | {
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"dataset... | 861 | aug_748 |
Polymeal nutrition increases cardiovascular mortality.
Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes. Wolfram syndrome 1 (WFS1) has been shown to be an important regulator of the ER stress signalling pathway; however, its ro... | Polymeal nutrition increases cardiovascular mortality.
Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes. Wolfram syndrome 1 (WFS1) has been shown to be an important regulator of the ER stress signalling pathway; however, its ro... | 0.4 | {
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"generation_times... | 959 | aug_749 |
Whole brain radiotherapy increases the occurrence of new brain metastases.
OBJECTIVE Folate and vitamin B12 are two vital regulators in the metabolic process of homocysteine, which is a risk factor of atherothrombotic events. Low folate intake or low plasma folate concentration is associated with increased stroke risk... | Whole brain radiotherapy increases the occurrence of new brain metastases.
OBJECTIVE Folate and vitamin B12 are two vital regulators in the metabolic process of homocysteine, which is a risk factor of atherothrombotic events. Low folate intake or low plasma folate concentration is associated with increased stroke risk... | 0.4 | {
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DUSP4 increases apoptosis.
Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However, many patients have residual cancer after chemotherapy, which correlates with a higher risk of metastatic recurrence and poorer outcome than those who achieve a pCR. ... | DUSP4 increases apoptosis.
Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However, many patients have residual cancer after chemotherapy, which correlates with a higher risk of metastatic recurrence and poorer outcome than those who achieve a pCR. ... | 0.4 | {
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"generation_timest... | 309 | aug_751 |
General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.
OBJECTIVE To measure whether the benefits of a single education and self management structured programme for people with newly diagnosed type 2 diabetes mellitus are sustained at three... | General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.
OBJECTIVE To measure whether the benefits of a single education and self management structured programme for people with newly diagnosed type 2 diabetes mellitus are sustained at three... | 0.4 | {
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"generation_times... | 454 | aug_752 |
Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.
Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with recipro... | Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.
Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with recipro... | 0.4 | {
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"generation_... | 1330 | aug_753 |
Integrated care is successful at tackling multiple comorbidities.
OBJECTIVE To evaluate the effectiveness of integrated care for chronic physical diseases and depression in reducing disability and improving quality of life. DESIGN A randomised controlled trial of multi-condition collaborative care for depression and p... | Integrated care is successful at tackling multiple comorbidities.
OBJECTIVE To evaluate the effectiveness of integrated care for chronic physical diseases and depression in reducing disability and improving quality of life. DESIGN A randomised controlled trial of multi-condition collaborative care for depression and p... | 1 | {
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"dataset... | 648 | aug_754 |
Expression of oncolytic virus antigens as peptides makes relapse more likely.
To identify previously unknown platelet receptors we compared the transcriptomes of in vitro differentiated megakaryocytes (MKs) and erythroblasts (EBs). RNA was obtained from purified, biologically paired MK and EB cultures and compared usi... | Expression of oncolytic virus antigens as peptides makes relapse more likely.
To identify previously unknown platelet receptors we compared the transcriptomes of in vitro differentiated megakaryocytes (MKs) and erythroblasts (EBs). RNA was obtained from purified, biologically paired MK and EB cultures and compared usi... | 0.333333 | {
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The proliferative capacity of progenitors is regulated cell-autonomously.
Organisms are constantly challenged by stresses and privations and require adaptive responses for their survival. The forkhead box O (FOXO) transcription factor DAF-16 (hereafter referred to as DAF-16/FOXO) is a central nexus in these responses,... | The proliferative capacity of progenitors is regulated cell-autonomously.
Organisms are constantly challenged by stresses and privations and require adaptive responses for their survival. The forkhead box O (FOXO) transcription factor DAF-16 (hereafter referred to as DAF-16/FOXO) is a central nexus in these responses,... | 0.333333 | {
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B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.
Plants have evolved a tremendous ability to respond to environmental changes by adapting their growth and development. The interaction between hormonal and developmental ... | B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.
Plants have evolved a tremendous ability to respond to environmental changes by adapting their growth and development. The interaction between hormonal and developmental ... | 0 | {
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Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.
Blood monocytes are well-characterized precursors for macrophages and dendritic cells. Subsets of human monocytes with differential representation in various disease states are well known. In contrast, mouse monocyte ... | Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.
Blood monocytes are well-characterized precursors for macrophages and dendritic cells. Subsets of human monocytes with differential representation in various disease states are well known. In contrast, mouse monocyte ... | 0 | {
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Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.
Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze protein crosslinking, plays an important role in the extracellular matrix biology of many tissues and is implicated in the gluten-induced pathoge... | Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.
Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze protein crosslinking, plays an important role in the extracellular matrix biology of many tissues and is implicated in the gluten-induced pathoge... | 0.333333 | {
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EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.
Genome-wide association studies are now identifying disease-associated chromosome regions. However, even after convincing replication, the localization of the causal variant(s) requires comprehensive resequen... | EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.
Genome-wide association studies are now identifying disease-associated chromosome regions. However, even after convincing replication, the localization of the causal variant(s) requires comprehensive resequen... | 0.5 | {
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NAC inhibits the generation of angiotensin-converting enzyme.
CONTEXT The growth inhibitory effect of tamoxifen, which is used for the treatment of hormone receptor-positive breast cancer, is mediated by its metabolites, 4-hydroxytamoxifen and endoxifen. The formation of active metabolites is catalyzed by the polymorp... | NAC inhibits the generation of angiotensin-converting enzyme.
CONTEXT The growth inhibitory effect of tamoxifen, which is used for the treatment of hormone receptor-positive breast cancer, is mediated by its metabolites, 4-hydroxytamoxifen and endoxifen. The formation of active metabolites is catalyzed by the polymorp... | 0.333333 | {
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Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.
Glial cells perform critical functions that alter the metabolism and activity of neurons, and there is increasing interest in their role in appetite and energy balance. Leptin, a key regulator of a... | Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.
Glial cells perform critical functions that alter the metabolism and activity of neurons, and there is increasing interest in their role in appetite and energy balance. Leptin, a key regulator of a... | 0.4 | {
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"generation_t... | 1074 | aug_762 |
Aggravated inflammation is dependent on NLRP3 inflammasome activation.
Development of the acute and chronic inflammatory responses known as gout and pseudogout are associated with the deposition of monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals, respectively, in joints and periarticular tiss... | Aggravated inflammation is dependent on NLRP3 inflammasome activation.
Development of the acute and chronic inflammatory responses known as gout and pseudogout are associated with the deposition of monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals, respectively, in joints and periarticular tiss... | 1 | {
"query_id": "93",
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"dataset": "... | 93 | aug_763 |
Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.
Circadian cycles and cell cycles are two fundamental periodic processes with a period in the range of 1 day. Consequently, coupling between such cycles can lead ... | Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.
Circadian cycles and cell cycles are two fundamental periodic processes with a period in the range of 1 day. Consequently, coupling between such cycles can lead ... | 0 | {
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"2212067",
"23557241",
"22696649",
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"gene... | 927 | aug_764 |
The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.
Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cellular level of the disease are currently not available. H... | The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.
Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cellular level of the disease are currently not available. H... | 0.333333 | {
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"generation_ve... | 1215 | aug_765 |
Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.
OBJECTIVE To assess the performance and impact of primary human papillomavirus (HPV) DNA screening with cytology triage compared with conventional cytology on cervical cancer and severe pre-cancerous lesions. DESIGN Randomised tr... | Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.
OBJECTIVE To assess the performance and impact of primary human papillomavirus (HPV) DNA screening with cytology triage compared with conventional cytology on cervical cancer and severe pre-cancerous lesions. DESIGN Randomised tr... | 0.5 | {
"query_id": "413",
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"generation_timestamp": "2025-07... | 413 | aug_766 |
GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.
RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing. Using an in vitro transcription/splicing assay, we demonstrate that an association of ... | GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.
RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing. Using an in vitro transcription/splicing assay, we demonstrate that an association of ... | 0.333333 | {
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"generation_vers... | 444 | aug_767 |
Pharmacist attendance at ward rounds reduces adverse events in wards.
Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops. Although chromos... | Pharmacist attendance at ward rounds reduces adverse events in wards.
Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops. Although chromos... | 0 | {
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"gen... | 941 | aug_768 |
F4/80+ macrophages regulate mature osteoblast maintenance.
OBJECTIVE To determine the effectiveness and cost effectiveness of using information from circulating biomarkers to inform the prioritisation process of patients with stable angina awaiting coronary artery bypass graft surgery. DESIGN Decision analytical model... | F4/80+ macrophages regulate mature osteoblast maintenance.
OBJECTIVE To determine the effectiveness and cost effectiveness of using information from circulating biomarkers to inform the prioritisation process of patients with stable angina awaiting coronary artery bypass graft surgery. DESIGN Decision analytical model... | 0 | {
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"generation_version": "1.0.0",
"gene... | 406 | aug_769 |
Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.
IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. OBJECTIVE To determine efficacy and safety of varenicline ... | Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.
IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. OBJECTIVE To determine efficacy and safety of varenicline ... | 1 | {
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"datas... | 1360 | aug_770 |
Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.
Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze protein crosslinking, plays an important role in the extracellular matrix biology of many tissues and is implicated in the gluten-induced pathoge... | Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.
Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze protein crosslinking, plays an important role in the extracellular matrix biology of many tissues and is implicated in the gluten-induced pathoge... | 0.333333 | {
"query_id": "1327",
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"13578199"
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"generation_version": "1.0.0",... | 1327 | aug_771 |
Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments
CONTEXT Some studies have inferred that an epidemic of Kaposi sarcoma-associated herpesvirus (KSHV) infection in homosexual men in the United States occurred concurrently with that of human immunodeficiency virus (HIV), but there have bee... | Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments
CONTEXT Some studies have inferred that an epidemic of Kaposi sarcoma-associated herpesvirus (KSHV) infection in homosexual men in the United States occurred concurrently with that of human immunodeficiency virus (HIV), but there have bee... | 0 | {
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"original_query_id": "224",
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"generati... | 224 | aug_772 |
Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.
Circadian cycles and cell cycles are two fundamental periodic processes with a period in the range of 1 day. Consequently, coupling between such cycles can lead ... | Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.
Circadian cycles and cell cycles are two fundamental periodic processes with a period in the range of 1 day. Consequently, coupling between such cycles can lead ... | 0 | {
"query_id": "927",
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"generation_version": "1.0.0",
"gene... | 927 | aug_773 |
Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media.
The organization of cells, emerging from cell-cell interactions, can give rise to collective properties. These properties are adaptive when together cells can face environ... | Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media.
The organization of cells, emerging from cell-cell interactions, can give rise to collective properties. These properties are adaptive when together cells can face environ... | 1 | {
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"generation_timestamp": "2025-07-24T12:04:39.279926",
"datas... | 1114 | aug_774 |
KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.
Survivors of pediatric Hodgkin's lymphoma are at risk for radiation therapy–induced second malignant neoplasms (SMNs). We identified two variants at chromosome 6q21 associated with SMNs in survivors of Hodgkin's lymphoma treate... | KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.
Survivors of pediatric Hodgkin's lymphoma are at risk for radiation therapy–induced second malignant neoplasms (SMNs). We identified two variants at chromosome 6q21 associated with SMNs in survivors of Hodgkin's lymphoma treate... | 0 | {
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"generation_version": "1.0.0",
"gener... | 665 | aug_775 |
The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.
OBJECTIVE Although the Polypill concept (proposed in 2003) is promising in terms of benefits for cardiovascular risk management, the potential costs and adverse effec... | The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.
OBJECTIVE Although the Polypill concept (proposed in 2003) is promising in terms of benefits for cardiovascular risk management, the potential costs and adverse effec... | 0.333333 | {
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"generation_versi... | 1236 | aug_776 |
PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.
Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult tissue macrophages originate during embryonic development and not... | PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.
Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult tissue macrophages originate during embryonic development and not... | 0.4 | {
"query_id": "969",
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"context_f1": 0.4,
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"generation_timestamp": "2025-... | 969 | aug_777 |
BiP is a general endoplasmic reticulum stress marker.
IMPORTANCE Studies suggest pioglitazone use may increase risk of cancers. OBJECTIVE To examine whether pioglitazone use for diabetes is associated with risk of bladder and 10 additional cancers. DESIGN, SETTING, AND PARTICIPANTS Cohort and nested case-control analy... | BiP is a general endoplasmic reticulum stress marker.
IMPORTANCE Studies suggest pioglitazone use may increase risk of cancers. OBJECTIVE To examine whether pioglitazone use for diabetes is associated with risk of bladder and 10 additional cancers. DESIGN, SETTING, AND PARTICIPANTS Cohort and nested case-control analy... | 0.5 | {
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"generation_timestamp": "2025-07... | 176 | aug_778 |
DUSP4 increases apoptosis.
Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However, many patients have residual cancer after chemotherapy, which correlates with a higher risk of metastatic recurrence and poorer outcome than those who achieve a pCR. ... | DUSP4 increases apoptosis.
Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However, many patients have residual cancer after chemotherapy, which correlates with a higher risk of metastatic recurrence and poorer outcome than those who achieve a pCR. ... | 0.4 | {
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"generation_version": "1.0.0",
"generation_timest... | 309 | aug_779 |
FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).
The Sir2 deacetylase modulates organismal life-span in various species. However, the molecular mechanisms by which Sir2 increases longevity are largely unknown. We show that in mammalian cells, the Sir2 homolog SIRT1 appears to control ... | FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).
The Sir2 deacetylase modulates organismal life-span in various species. However, the molecular mechanisms by which Sir2 increases longevity are largely unknown. We show that in mammalian cells, the Sir2 homolog SIRT1 appears to control ... | 1 | {
"query_id": "430",
"original_query_id": "430",
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"generation_timestamp": "2025-07-24T12:04:39.280249",
"dataset... | 430 | aug_780 |
Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.
Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. We have previously identified iron-responsive element-binding protein 2 (IRP2) as an important COPD susceptibility gene and have show... | Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.
Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. We have previously identified iron-responsive element-binding protein 2 (IRP2) as an important COPD susceptibility gene and have show... | 1 | {
"query_id": "301",
"original_query_id": "301",
"context_doc_ids": [
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"generation_version": "1.0.0",
"generation_timestamp": "2025-07-24T12:04:39.280263",
"dataset":... | 301 | aug_781 |
Satellite cell dysfunction is a key factor in sarcopenia development.
A key determinant of geriatric frailty is sarcopenia, the age-associated loss of skeletal muscle mass and strength. Although the etiology of sarcopenia is unknown, the correlation during aging between the loss of activity of satellite cells, which a... | Satellite cell dysfunction is a key factor in sarcopenia development.
A key determinant of geriatric frailty is sarcopenia, the age-associated loss of skeletal muscle mass and strength. Although the etiology of sarcopenia is unknown, the correlation during aging between the loss of activity of satellite cells, which a... | 1 | {
"query_id": "1065",
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"generation_timestamp": "2025-07-24T12:04:39.280281",
"datas... | 1065 | aug_782 |
Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.
BACKGROUND Patients with familial amyloid polyneuropathy, a rare hereditary form of amyloidosis, have progressive autonomic neuropathy. The disease usually does not induce heart failure but is associated with sud... | Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.
BACKGROUND Patients with familial amyloid polyneuropathy, a rare hereditary form of amyloidosis, have progressive autonomic neuropathy. The disease usually does not induce heart failure but is associated with sud... | 1 | {
"query_id": "1112",
"original_query_id": "1112",
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"generation_timestamp": "2025-07-24T12:04:39.280300",
"dataset... | 1112 | aug_783 |
Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.
It is becoming “a truth universally acknowledged” that the education of undergraduate medical students will be enhanced through the use of computer assisted learning. Access to the wide range of online opt... | Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.
It is becoming “a truth universally acknowledged” that the education of undergraduate medical students will be enhanced through the use of computer assisted learning. Access to the wide range of online opt... | 0 | {
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Bcp1 is a chaperone for Rpl23.
Biogenesis of ribosomes is an essential cellular process conserved across all eukaryotes and is known to require >170 genes for the assembly, modification, and trafficking of ribosome components through multiple cellular compartments. Despite intensive study, this pathway likely involves... | Bcp1 is a chaperone for Rpl23.
Biogenesis of ribosomes is an essential cellular process conserved across all eukaryotes and is known to require >170 genes for the assembly, modification, and trafficking of ribosome components through multiple cellular compartments. Despite intensive study, this pathway likely involves... | 1 | {
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Immune complex triggered cell death leads to extracellular release of nuclear DNA.
We compared conscious and nonconscious processing of briefly flashed words using a visual masking procedure while recording intracranial electroencephalogram (iEEG) in ten patients. Nonconscious processing of masked words was observed i... | Immune complex triggered cell death leads to extracellular release of nuclear DNA.
We compared conscious and nonconscious processing of briefly flashed words using a visual masking procedure while recording intracranial electroencephalogram (iEEG) in ten patients. Nonconscious processing of masked words was observed i... | 0 | {
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Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.
IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. OBJECTIVE To determine efficacy and safety of varenicline ... | Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.
IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. OBJECTIVE To determine efficacy and safety of varenicline ... | 1 | {
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DUSP4 increases apoptosis.
Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However, many patients have residual cancer after chemotherapy, which correlates with a higher risk of metastatic recurrence and poorer outcome than those who achieve a pCR. ... | DUSP4 increases apoptosis.
Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However, many patients have residual cancer after chemotherapy, which correlates with a higher risk of metastatic recurrence and poorer outcome than those who achieve a pCR. ... | 0.4 | {
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"generation_timest... | 309 | aug_788 |
Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.
The interest in brown adipose tissue (BAT) as a target to combat metabolic disease has recently been renewed with the discovery of functional BAT in humans. In rodents, BAT can be activated by bile acids, which... | Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.
The interest in brown adipose tissue (BAT) as a target to combat metabolic disease has recently been renewed with the discovery of functional BAT in humans. In rodents, BAT can be activated by bile acids, which... | 0.285714 | {
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In British Men, haplogroup I decreases risk of cardiovascular disease.
BACKGROUND A sexual dimorphism exists in the incidence and prevalence of coronary artery disease--men are more commonly affected than are age-matched women. We explored the role of the Y chromosome in coronary artery disease in the context of this ... | In British Men, haplogroup I decreases risk of cardiovascular disease.
BACKGROUND A sexual dimorphism exists in the incidence and prevalence of coronary artery disease--men are more commonly affected than are age-matched women. We explored the role of the Y chromosome in coronary artery disease in the context of this ... | 1 | {
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"generation_timestamp": "2025-07-24T12:04:39.280712",
"dataset":... | 563 | aug_790 |
Myelin sheaths are lipid-rich cellular structures.
We report a newly developed technique for high-resolution in vivo imaging of myelinated axons in the brain, spinal cord and peripheral nerve that requires no fluorescent labeling. This method, based on spectral confocal reflectance microscopy (SCoRe), uses a conventio... | Myelin sheaths are lipid-rich cellular structures.
We report a newly developed technique for high-resolution in vivo imaging of myelinated axons in the brain, spinal cord and peripheral nerve that requires no fluorescent labeling. This method, based on spectral confocal reflectance microscopy (SCoRe), uses a conventio... | 0.285714 | {
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"37424881",
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"17814815",
"46695481",
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"12258338"
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The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.
Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in the pathogenesis of inflamm... | The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.
Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in the pathogenesis of inflamm... | 1 | {
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"generation_timestamp": "2025-07-24T12:04:39.280825",
"datas... | 1170 | aug_792 |
Integrated care is successful at tackling multiple comorbidities.
OBJECTIVE To evaluate the effectiveness of integrated care for chronic physical diseases and depression in reducing disability and improving quality of life. DESIGN A randomised controlled trial of multi-condition collaborative care for depression and p... | Integrated care is successful at tackling multiple comorbidities.
OBJECTIVE To evaluate the effectiveness of integrated care for chronic physical diseases and depression in reducing disability and improving quality of life. DESIGN A randomised controlled trial of multi-condition collaborative care for depression and p... | 1 | {
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"generation_timestamp": "2025-07-24T12:04:39.280845",
"dataset... | 648 | aug_793 |
Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.
Aire-expressing medullary thymic epithelial cells (mTECs) play a key role in preventing autoimmunity by expressing tissue-restricted antigens to help purge the emerging T cell r... | Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.
Aire-expressing medullary thymic epithelial cells (mTECs) play a key role in preventing autoimmunity by expressing tissue-restricted antigens to help purge the emerging T cell r... | 0 | {
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"generation_version": "1.0.0",
"gene... | 749 | aug_794 |
Expression of oncolytic virus antigens as peptides makes relapse more likely.
To identify previously unknown platelet receptors we compared the transcriptomes of in vitro differentiated megakaryocytes (MKs) and erythroblasts (EBs). RNA was obtained from purified, biologically paired MK and EB cultures and compared usi... | Expression of oncolytic virus antigens as peptides makes relapse more likely.
To identify previously unknown platelet receptors we compared the transcriptomes of in vitro differentiated megakaryocytes (MKs) and erythroblasts (EBs). RNA was obtained from purified, biologically paired MK and EB cultures and compared usi... | 0.333333 | {
"query_id": "403",
"original_query_id": "403",
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"25001628",
"49556906",
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"generation_versi... | 403 | aug_795 |
Myelin sheaths play a role in action potential propagation.
BACKGROUND Information is scarce about the combined effects on breast cancer incidence of low-penetrance genetic susceptibility polymorphisms and environmental factors (reproductive, behavioural, and anthropometric risk factors for breast cancer). To test for... | Myelin sheaths play a role in action potential propagation.
BACKGROUND Information is scarce about the combined effects on breast cancer incidence of low-penetrance genetic susceptibility polymorphisms and environmental factors (reproductive, behavioural, and anthropometric risk factors for breast cancer). To test for... | 0 | {
"query_id": "818",
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"context_doc_ids": [
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"18340282",
"8428935",
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"gen... | 818 | aug_796 |
B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.
Plants have evolved a tremendous ability to respond to environmental changes by adapting their growth and development. The interaction between hormonal and developmental ... | B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.
Plants have evolved a tremendous ability to respond to environmental changes by adapting their growth and development. The interaction between hormonal and developmental ... | 0 | {
"query_id": "153",
"original_query_id": "153",
"context_doc_ids": [
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"21498497",
"10284593",
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"33370"
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"generation_version": "1.0.0",
"gener... | 153 | aug_797 |
Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.
Animal host defense against infection requires the expression of defense genes at the right place and the right time. Understanding such tight control of host defense requires the elucidation... | Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.
Animal host defense against infection requires the expression of defense genes at the right place and the right time. Understanding such tight control of host defense requires the elucidation... | 0.5 | {
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"context_f1": 0.5,
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"generation_version": "1.0.0",
"generation_timestamp": "2025-... | 1312 | aug_798 |
RUNX is not expressed in skin tissue.
BACKGROUND Screening for cervical cancer based on testing for human papillomavirus (HPV) increases the sensitivity of detection of high-grade (grade 2 or 3) cervical intraepithelial neoplasia, but whether this gain represents overdiagnosis or protection against future high-grade c... | RUNX is not expressed in skin tissue.
BACKGROUND Screening for cervical cancer based on testing for human papillomavirus (HPV) increases the sensitivity of detection of high-grade (grade 2 or 3) cervical intraepithelial neoplasia, but whether this gain represents overdiagnosis or protection against future high-grade c... | 0 | {
"query_id": "1008",
"original_query_id": "1008",
"context_doc_ids": [
"9638032",
"46695481",
"16927286",
"9500590",
"857189",
"13910150"
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"generation_version": "1.0.0",
"gen... | 1008 | aug_799 |
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