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#' @name DEPRECATED-orderwl #' @concept deprecated #' #' @title (DEPRECATED) #' Sorting the wavelengths of a `hyperSpec` object #' #' @description #' These \pkg{hyperSpec} functions are **deprecated** and not maintained any #' more. You should not use these. #' Currently they are present due to back-compatibilit...
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source('./scripts/01_Setup.R') SignificantCells <- readRDS("./data/processed/rds/SignificantCells.rds") SignificantCells= SignificantCells[SignificantCells$data%in% c('PTA', 'PicoPLEX'),] delimiters = ".bowtie|.bt2" aa= strsplit(SignificantCells$id, delimiters, perl=T) aa2= sapply(aa, function(x) x[1]) aa2= standard...
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#' mochims__predict_fitness #' #' Predict fitness from folding and binding energies for 3-state model. #' #' @param mochi_outpath path to MoCHI thermo model fit results (required) #' @param dataset_name dataset name (required) #' @param folding_energy folding energies for 3-state model (required) #' @param binding_ene...
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setwd('../data_raw') folders = list.dirs(recursive = F, full.names = F) for(participant in folders){ setwd(participant) files=dir(pattern='.csv') # Read the data of one subject data = read.csv(files[1]) # Find the scanning onset, offset and moment of each volume (be careful - slice time correction ...
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--- title: "Phenotype distribution" format: html editor: visual --- This notebook contains plots with the distribution of continuous variables in our project. ```{r setup, echo = FALSE, message=FALSE, warning=FALSE, include=FALSE} library(dplyr) # Load data base::load(snakemake@input[[1]]) # Unlist for ease of life...
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# Variable, global to package's namespace. # This function is not exported to user space and does not need to be documented. opt= settings::options_manager( thresh= 3, speed_method= "z", extend_by= 3, island_size= 4, extend_blink= 3, overall_thresh= 0.4, consecutive_thresh= NULL, disable_smoothing= F...
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#### Markos et al 2024 #### Script used for analysis of 10X matrices #### Crest markers # load prerequisities library(Seurat) library(patchwork) library(ggplot2) # load output of AmphiN5stage.R AmphiN5stage <- readRDS("../timepoints_rds/Amp_N5.RDS") AmphiN5stage@active.ident <- factor( AmphiN5stage@active.iden...
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# Adapted from Matlab code: # https://data.mrc.ox.ac.uk/data-set/simulated-eeg-data-generator # function signal = noise (frames, epochs, srate) # # % function signal = noise (frames, epochs, srate) # % # % Function generates noise with the power spectrum of human EEG # % Inputs: # % frames - number of signal frame...
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#' Gene summary plot of neuroimaGene object #' #' Generates an overview plot of the neuroimaGene object according to each gene input. #' @param ng_obj NeuroimaGene Object #' @param maxGns maximum number of genes to visualize. default=15 #' @param title optional title tag for the plot #' @param verbose print runtime mes...
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#' Create a simple plot of a phylogenetic tree and tag monophyletic groups #' #' This function creates a simple plot of a phylogenetic tree and tags the monophyletic groups on the plot. #' It is a wrapper function that combines the functionality of two other functions: #' `create_simple_plot_boostrap_lab_fun()` and `...
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#----01_setup------------------------------------------------------------------- #------------------------------------------------------------------------------- # This is the setup file for the connectivity analysis for # Reinhard and Fukuda et al. 2024 # Here all necessary libraries are loaded and all used funct...
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# load libraries library(tidyverse) library(data.table) library(Seurat) library(singleCellNet) library(WGCNA) set.seed(1234) args = commandArgs(trailingOnly = TRUE) ref_path = args[1] lab_path = args[2] out_path = args[3] threads = as.numeric(args[4]) nTrees = as.numeric(args[5]) #--------------- Data --------------...
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################################# # # This function used to illustrate # the correlation matrix # ShowCorMat <- function(result_mat, lower = -1, upper = 1, title_text = "Correlation Matrix"){ library(ggeasy) # define the color palette jet.colors <- colorRampPalette(c("#00007F", "blue", "#007FFF", "cyan...
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#' @name DEPRECATED-read.ini #' @concept moved to hySpc.read.txt #' #' @title (DEPRECATED) #' Read INI files #' #' @description #' #' These data input functions are **deprecated** and they will be removed in #' the next release of \pkg{hyperspec} package. #' Now functions in package \pkg{hySpc.read.txt} #' ([lin...
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#================================================== # Figure S1: Heatmap of NPE correlations #================================================== library(data.table) library(magrittr) library(psych) library(pheatmap) library(polycor) pheno <- fread("shared/nacc_rosmap_act_np.pheno", na.strings = "-1") covar <- fread("...
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setwd('C:/Users/au571303/Documents/projects/memory_music_iEEG') library(MASS) library(lme4) library(effects) library(ggplot2) library(viridis) library(RColorBrewer) library(ez) library(ordinal) files <- list.files('logs', pattern = 'pilot') # load all pilot files: d <- data.frame() for (f in files){ cdata <- read...
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#======================================================= # create data set with 4 CpG, SNP, CAA, and covariates #======================================================= library(data.table) library(readxl) library(ordinal) load("data/cpg.RData") covar <- setDT(read_xlsx("/data_global/ROSMAP/greg_20200109/dataset_843_b...
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args <- commandArgs(trailingOnly = TRUE) fasta_file <- args[1] output_dir <- args[2] log_file <- args[3] log_con <- file(log_file, open = "wt") sink(log_con, type = "output") sink(log_con, type = "message") library(Biostrings) library(dplyr) library(ggplot2) tryCatch({ # Read the fasta file reads <- readAAString...
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#!/usr/bin/env Rscript # This script is used to extract segments from NVI consensus files insaflu # from cath naming # renaming segt_isolate.fasta require(optparse) library(tidyverse) library(seqinr) option_list = list( make_option("--sample", action = "store", type = 'character', h...
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#' @name DEPRECATED-read.asc.PerkinElmer #' @concept moved to hySpc.read.txt #' #' @title (DEPRECATED) #' File import filter PerkinElmer ASCII spectra #' #' @description #' #' These data input functions are **deprecated** and they will be removed in #' the next release of \pkg{hyperspec} package. #' Now function...
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#============================================================================= # Compare gene expression of COL4A1 and PIK3R5 with atherosclerosis and Braak #============================================================================= library(data.table) library(ordinal) library(readxl) library(ggplot2) rnaseq <- fre...
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penalizations <- c(0.05, 0.1, 0.2, 0.3, 0.4) library(scregclust) library(progressr) library(doFuture) plan(multisession) # Will be the dataset "wang" or "pbmc" dataset <- commandArgs(trailingOnly = TRUE)[1] output_path <- file.path("output", sprintf("%s-scregclust", dataset)) if (!dir.exists(output_path)) { dir.c...
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#' Elevated CO_2 and total biomass of woody plants #' #' @description #' Meta-analysis on effects of elevated CO_2 on total biomass of woody #' plants #' #' This dataset has been used as an example in Hedges et al. (1999) to #' describe methods for the meta-analysis of response ratios. The #' complete dataset with 10...
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#Function borrowed from reticulate (accessed 09.12.2024, partly updated with 02.09.2026): #https://github.com/rstudio/reticulate/blob/main/R/miniconda.R #This is used to specify a version of miniconda instead of installing the latest to ensure compatibility with the VertexWiseR requirements miniconda_installer_py310ur...
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library(Seurat) load("Supp1_CellLine_R1/WT3CL_YWsubset_intObj_20230418.Robj") ### obtain AEI through RNAEditingIndexer input_dir <- "/media/Scratch_SSD_Voyager/sammi/RNA_editing/AEI_CL_v1/output_index_20230420/" aei_table <- list() celltype_order <- c("Neural-Progenitors","Neurons","Retinal-Epi","SCP","Gut-Epi","HSC...
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library(chromVAR) library(motifmatchr) library(Matrix) library(SummarizedExperiment) library(BiocParallel) library(JASPAR2020) library(readr) library(stats) library(BSgenome.Hsapiens.UCSC.hg38) library(TFBSTools) library(Signac) library(Seurat) # Running Human chromVAR (Get Peak Motif Colocation Information) input_dir...
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--- title: "Here and File Architecture Setup" author: "Katie Emberley, Jonathan Nelson, and Annie Lackey" date: "`r format(Sys.time(), '%d %B %Y')`" output: html_document: toc: yes toc_depth: 3 toc_float: true number_sections: yes theme: bootstrap df_print: paged code_folding: hide hi...
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library(DESeq2) setwd("~/Library/Mobile Documents/com~apple~CloudDocs/Documents/Projects/GF_Mouse_Human_v_Primate/GF_Mouse_Human/First_experiment/Final_analysis") #read in raw count data and metadata with columns of first matching rows of second countdata<-read.csv("Liver_gene_expression_rawcounts.csv", row.names = "...
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#!/usr/bin/env Rscript args <- commandArgs(trailingOnly=TRUE) if (length(args) < 1) { cat("\nqualSummaryStats.R <list of files with quality values (one file per row)> <outfile name> [column numbers to analyze]\n\n") options(show.error.messages=FALSE) stop() } flist <- as.character(read.table(a...
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context("Input detection") # Positive definite matrix x.spd <- matrix(c(1,.5,.5,1), ncol = 2) x.s <- matrix(c(-1,.5,.5,-1), ncol = 2) x.spdl <- lapply(1:5, function(i) x.spd) x.sl <- x.spdl; x.sl[[1]] <- x.s x.ns <- matrix(c(1,.5,.75,1), ncol = 2) x.nsl <- x.spdl; x.nsl[[1]] <- x.ns x.npdl <- x.spdl; x.npdl[...
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#' Smoking example #' #' @description #' Meta-analyses on the effect of smoking on mortality risk. #' #' @details #' Data have been reconstructed based on the famous Smoking and Health #' Report to the Surgeon General (Bayne-Jones S et al., 1964). Data #' sets can be used to evaluate the risk of smoking on overall #'...
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#' Conduct dictionary-based sentiment analysis. #' #' @description Tokenizes character vectors, counts words, and then takes weighted average to estimate sentiment. #' @usage sentiment(x,tokens,scores) #' @param x length n character vector. If you're input dictionary is lower case only, then be sure to preprocess input...
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## Compute the overlaps between two *numeric* lists: numericListOverlap<- function(sample1, sample2, stepsize, method="hyper", tol = 0.5, offset = 1){ n<- length(sample1) overlap_hyper <- function(a,b) { count<-as.integer(sum(as.numeric(sample1[1:a] %in% sample2[1:b]))) signs<- 1L log.pval<- -ph...
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# File: compute_MCMC_CI.R # Author: Kelly Chang # Date: Oct 2017 # Version: 1.0 # # Description: R script to compute credible intervals from MCMC results. # For help, run this script with command line option "-h". # #--- specify command line arguments library(optparse) parser...
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#' @name DEPRECATED-read.asc.Andor #' @concept moved to hySpc.read.txt #' #' @title (DEPRECATED) #' Import Raman spectra/maps from Andor cameras/solis ASCII files #' #' @description #' These data input functions are **deprecated** and they will be removed in #' the next release of \pkg{hyperspec} package. #' Now...
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# Get command line arguments args = commandArgs(trailingOnly=TRUE) outfmt=args[1] sample_name=args[2] fmt=args[3] outdir=args[4] # Load required packages library(tidyverse) # Required functions log_message <- function(message) { cat(sprintf("[%s %s\n]", Sys.time(), message)) } save_plot <- function(plot, filename)...
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# This script further specifically does the GC for the schizophrenia associated genes using FPP30 cell type models. # load library library(data.table) library(foreach) library(doParallel) library(tidyverse) library(broom) # read in the GReX files fpp11 <- fread("/data/g_***/FPP11_eur.csv", h=T) fpp30 <- fread("/data/...
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#' Trim rPCA loadings according to heuristics and append them to the original object #' #' Under development. This function takes a 'reduce_rPCA' object, #' and only a 'reduce_rPCA' object, and trims the original loadings. #' The trimmed loadings can then be used for (new) predictions #' with 'predict_feature()', for e...
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# Function ------------------------------------------------------------------- .split <- function(x, f, drop = TRUE) { validObject(x) hyperlist <- split(seq(x, index = TRUE), f, drop) for (i in seq_along(hyperlist)) { hyperlist[[i]] <- x[hyperlist[[i]], ] } hyperlist } #' Split a `hyperSpec` object ...
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library(data.table) library(Biostrings) library(rhdf5) library(reshape2) source("coefplot.r") h5dir = args[1] testIDs = h5read(paste(h5dir, "test.h5", sep='/'),"geneName") trainIDs = h5read(paste(h5dir, "train.h5", sep='/'),"geneName") valIDs = h5read(paste(h5dir, "valid.h5", sep='/'),"geneName") file1 = "Roadmap_Fant...
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#' @name deprecated #' @concept deprecated #' #' @title Deprecated and defunct functions #' #' @description #' These \pkg{hyperSpec} functions are **deprecated** and not maintained any #' more. You should not use these. #' Currently they are present due to back-compatibility reasons and will be #' removed in the next r...
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library(latticeExtra) getresults = function(thisfile){ sites = read.table(text = system(paste("python print_losses.py", thisfile), intern=T), sep='\t') colnames(sites)=c("leftpos","rightpos","loss","params") print(sites[which(sites$loss == min(sites$loss)),]) say(nrow(sites), "trials") sites...
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#=============================================== # Create list of duplicates to remove #=============================================== library(pacman) p_load(data.table, magrittr, stringi) cargs <- commandArgs(trailingOnly = TRUE) prefix <- "act" np_ids <- fread("data/act_np_ids.txt", header = FALSE) miss <- fread(pa...
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test_that("cidprop transforms thresholds for supported summary measures", { dat.prop <- data.frame(event = c(2, 5, 8, 12, 18), n = c(30, 40, 35, 50, 45)) dat.rate <- data.frame(event = c(2, 5, 8, 12, 18), time = c(30, 40, 35, 50, 45)) dat.mean <- data.frame(n = c(...
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###Cell type classification with sctype #2022-06-06 #Jessy Slota # load libraries and functions lapply(c("dplyr","Seurat","HGNChelper"), library, character.only = T) source("https://raw.githubusercontent.com/IanevskiAleksandr/sc-type/master/R/gene_sets_prepare.R"); source("https://raw.githubusercontent.com/Ianev...
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# loading libraries library(Seurat) # v5.0.3 library(SeuratWrappers) library(patchwork) library(dplyr) library(ggplot2) library(sctransform) library(glmGamPoi) # Loading data Ctrl1.data <- Read10X_h5("~/Downloads/scRNA/Ctrl1_filtered_feature_bc_matrix.h5") Ctrl2.data <- Read10X_h5("~/Downloads/scRNA/Ctrl2_filtered_...
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# Get the command line arguments args = commandArgs(trailingOnly=TRUE) annotation=args[1] cog=args[2] sample_name=args[3] fmt=args[4] outdir=args[5] # Load necessary libraries library(tidyverse) library(ggthemes) library(svglite) # Required functions log_message <- function(message) { cat(sprintf("[%s %s\n]", Sys.t...
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suppressPackageStartupMessages({ library(readxl) library(tidyverse) library(openxlsx) library(tximport) library(DESeq2) library(pheatmap) library(biomaRt) }) if (!file.exists("biomart.rds")){ mart <- useMart("ENSEMBL_MART_ENSEMBL") mart <- useDataset("mmusculus_gene_ensembl", mart) atr...
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# File: generate_bootstrap_samples.R # Author: Kelly Chang # Date: Oct 2017 # Version: 1.0 # # Description: R script to generate bootstrap samples from hERG channel # fractional block data for 12 CiPA training drugs. # New drugs can be specified by running this s...
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# Function ------------------------------------------------------------------- .quantile <- function(x, probs = seq(0, 1, 0.5), na.rm = TRUE, names = "num", ...) { x <- apply(x, 2, quantile, probs = probs, na.rm = na.rm, names = FALSE, ..., long = list(probs = probs, na.rm = na.rm, names = names, ...) ) ...
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--- title: "heatmap" author: "Gokberk Alagoz, L&G Dept., MPI for Psycholinguistics" date: "`r Sys.Date()`" output: rmarkdown::github_document --- ```{r setup, include=FALSE} knitr::opts_chunk$set(echo = TRUE) library(dplyr) library(tidyr) library(ggplot2) library(ComplexHeatmap) library(circlize) ``` ```{r readAndPre...
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args <- commandArgs(trailingOnly = T) filenamex=as.character(args[[1]]) options(scipen=999) set.seed(1) for (t in 1:length(namex)){ filenamex= namex[t] outpath= file.path("./data/processed") source('./scripts/01_Setup.R') setwd(file.path(outpath, filenamex)) aa= read.table('analysis', header = T)[,1] d...
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#commonTheme commonTheme= ggplot2::theme( text= ggplot2::element_text(size= 14, face= "bold"), axis.text= ggplot2::element_text(size= 14, face= "bold", color= "black")) #' Plots two time series against each other #' #' The function plots two time series against each other. #' The intended use is generally to chec...
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#' Compute the mean of a set of spd matrices #' #' Function computes the mean of a set of symmetric positive-definite matrices. #' Several methods are implemented, as described in \code{Details}. #' #' @param x A list of symmetric, positive-definite matrices #' @param method The type of mean to compute. See details #' ...
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library(nlme) library(car) library(mosaic) setwd("~/Library/Mobile Documents/com~apple~CloudDocs/Documents/Projects/GF_Mouse_Human_v_Primate/GF_Mouse_Human/First_experiment/Final_analysis") data<-read.csv("Phys_combined_corrected_adults.csv") percent_weight<-lm(percent_weight_gain~Species, data=data) summary(aov(pe...
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#' Create study labels in JAMA layout (deprecated function) #' #' @description #' Deprecated function to create study labels in JAMA layout (for #' forest plot). Replaced by \code{\link{labels.meta}}. #' #' @details #' This auxiliary function can be used to create study labels in JAMA #' layout which can be added to ...
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# File: combine_results.R # Author: Kelly Chang # Date: Oct 2017 # Version: 1.0 # # Description: R script to aggregate action potential (AP) simulation # results. # For help, run this script with command line option "-h". # #--- specify command line arguments li...
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--- title: "LDSC" author: "Jack Humphrey" date: "27/01/2023" output: html_document --- ```{r setup, include=FALSE} knitr::opts_chunk$set(echo = TRUE) library(tidyverse) ``` ```{r} farrell <- read_tsv(here::here("data/Farrell_PSP.cell_type_results.txt") ) %>% mutate(disease = "PSP - this study") nalls <- read_tsv(her...
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test_that("metareg robust methods work without cluster", { skip_if_not_installed("metadat") data(dat.konstantopoulos2011, package = "metadat") dat <- dat.konstantopoulos2011 dat$group <- factor(ifelse(dat$district <= median(dat$district), "A", "B")) ma <- metagen(yi, sqrt(vi), studlab = study, ...
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#!/zs32/home/frwang/software/R-3.4.0/bin/Rscript library(qvalue) library(preprocessCore) library(peer) #Read command line arguments args <- commandArgs(trailingOnly = TRUE) try(if(length(args) != 3) stop("Incorrect number of arguments, usage> Rscript RNA_processing.R INPUT PEER_factor OUTPUT")) opt_input = args[1]; o...
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wd = "C:\\" ## Change filepath of working directory setwd(wd) #### Install package metafor library(metafor) ### Observational Practice vs. Rest # Load Dataset data = read.csv("direct_effects_obs_rest.csv") # Compute effect sizes for clockwise perturbation studies es1 <- escalc(measure="SMD", m1i=m_olcs,...
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args <- commandArgs(trailingOnly = T) filenamex=as.character(args[[1]]) options(scipen=999) set.seed(1) for (t in 1:length(namex)){ filenamex= namex[t] outpath= file.path("./data/processed") source('./scripts/01_Setup.R') setwd(file.path(outpath, filenamex)) aa= read.table('analysis', header = T)[,1] d...
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#setwd("D:/0AALRJ/scRNA-seq/VAE/scDisco/experiences/simulate") rm(list=ls()) library(SeuratDisk) library(Seurat) library(stringr) library(aricode) library(rhdf5) library(Matrix) # ### 2. Running Complete data by seurat ------------------------------------------------- data_dir = '../../datasets/human_lung/' ...
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########################### # # This function is used to conducted # permutation test for group difference # time delay estimation between HC # and subtype, or between two subtypes. # # R packages coin and tidyverse are essential # for this function. # # Liang Qunjun TtestBrain <- function(data, subtype1, subtype2...
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#' Covariance estimation #' #' Function implements several forms of covariance estimation. #' #' @param x A data matrix, where rows are observations and columns are variables #' @param method Method of covariance estimation. See details #' @param ... Additional arguments passed to estimation functions. See details. #'...
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#' Cisapride in Non-Ulcer Dispepsia #' #' @description #' Meta-analysis on cisapride in non-ulcer dispepsia. #' #' This meta-analysis is used as a data example in Hartung and Knapp #' (2001). #' #' @name cisapride #' #' @docType data #' #' @format A data frame with the following columns: #' \tabular{rl}{ #' \bold{...
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#' Creates a dataframe from the file containing a list of duplicates #' #' `create_duplicates_df` reads a file containing a list of duplicates, as produced by seqkit, #' and creates a dataframe with information about the duplicates. The file should be in #' tab-separated values (TSV) format with two columns: "ndub" and...
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library(Seurat) library(scregclust) library(data.table) path <- "data/Wang2019" if (!dir.exists(path)) { zip_file <- "data/Data_Wang2019_Brain.zip" if (!file.exists(zip_file)) { # Download link for data from Wang et al. (2019) # from https://www.weizmann.ac.il/sites/3CA/brain url <- paste0( "http...
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##### Supplementary Figure 2-a ##### # Transcriptional changes of six GT28 genes in male accessory glands (MAG) # at 0, 1, and 2 days after eclosion # # MAG bulk RNA sequencing data is deposited in NCBI SRA (PRJNA1140569). # RNA-seq row data was process using kallisto to generate 'MAG_day0-3.txt' file. # fbgn_fbtr_fbp...
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#' data wrangling for phylogenetic annotations with ggtree::geom_facet #' #' @description #' Returns a dataframe for phylogenetic annotations with ggtree::geom_facet #' with options geom_text and geom_tile, for a categorical variable that is stored in a #' nested contingency table. #' #' @details #' `get_ctg_dat...
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--- title: "Wilcox BoxPlots" author: "Abdullah Khan" date: "2025-04-01" output: html_document editor_options: chunk_output_type: console --- ```{r} library(openxlsx) library(ggplot2) library(ggpubr) library(tidyr) library(dplyr) library(ggsignif) path <- "/bgfs/ialdiri/Boxplots/" ``` ### Load in excel sheets ```{...
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#' contingency_df_variable_fun #' Contingency DataFrame Variable Function #' #' This function takes a data frame, a list of variables, and an optional grouping variable, and returns a contingency data frame. #' The contingency data frame summarizes the values of the variables for each group. #' For each variable, it al...
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AnalyseExperimentShort<-function(dr, dataname, resdr, cropLim, knn){ # performs a simpler analysis than AnalyseExperiment library(scatterplot3d) library(spatstat) library(spptest) library(ggplot2) source('Thomas3d.R') nn = knn nrsim<-49 delta<-10000 # size of analyzed images patches pb<-read...
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load("/media/Scratch_SSD_Voyager/sammi/RNA_editing/Figure3_ADARKO_R1/KO_4ter_project_SO_annot_collapsed_ADARB1-1rm_20230207.rda") Idents(KO_sub) <- KO_sub$guide comps <- data.frame(compA = c("ADAR1","ADARB1","ADARB2"), compB = rep("AAVS1", 3)) JNKgenes <- c("TRAF3","TRAF4","GADD45A","GADD45B","CCN2","GADD45G","TNFRSF1...
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#' mochims_structure_metrics #' #' Add 3D structure metrics. #' #' @param input_file path to MoCHI thermo model fit results (required) #' @param outpath output path for plots and saved objects (required) #' @param pdb_file path to PDB file (required) #' @param execute whether or not to execute the analysis (default: T...
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### R-4.3.1 # library library(edgeR) library(RColorBrewer) library(pheatmap) colors = brewer.pal(8, "Set2") ### HCC data data = read.table('../data/pivot_160_FRepr.txt', sep = '\t', header = T) rownames(data) = data$Gene data = data[-c(1:13)] group = factor(ifelse(grepl('T', colnames(data)), 'Tumor', 'N...
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#libraries library(xlsx) library(car) library(lmPerm) library(dplyr) #set the paths pvt_path = '/m/cs/scratch/networks-pm/effects_externalfactors_on_functionalconnectivity/data/cognitive/sub-01_day-all_device-presentation_test-pvt.csv' nback_path = '/m/cs/scratch/networks-pm/effects_externalfactors_on_functionalconnec...
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library(data.table) library(ggplot2) library(ordinal) dt <- fread("data/rosmap_data.csv") dt[, caa_4gp := ordered(caa_4gp)] dt[, apoe := factor(apoe, levels = c("apoe33", "apoe22", "apoe23", "apoe34", "apoe44"))] apoc2_plot = dt[!is.na(rs7247551_G) & !is.na(APOC2), ggplot(.SD, aes(factor(rs7247551_G)...
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library(ArchR) library(BSgenome.Hsapiens.UCSC.hg38) library(TFBSTools) library(JASPAR2020) addArchRThreads(threads = 8) addArchRGenome("hg38") # Load Data adata = loadArchRProject('HumanBrain') # Add JASPAR2020 motifs PWM <- getMatrixSet( x = JASPAR2020, opts = list(collection = "CORE", tax_group = 'vertebrate...
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# load libraries and arguments library(tibble) library(data.table) library(Seurat) library(WGCNA) set.seed(1234) #---------- Parameters ------------------- args = commandArgs(trailingOnly = TRUE) ref_path = args[1] lab_path = args[2] out_path = args[3] threads = as.numeric(args[4]) nPC_computed = as.numeric(args[5])...
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##------------------------- ## ordinal regression ##------------------------- library(pacman) p_load(data.table, magrittr, MASS, brant) #.raw file from regression.sh output with variant minor allele #values for each participant raw <- fread("02_analysis/ordinal/top.snps.raw") # file with other variables for each ...
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#' List NIDPs #' #' Supplies a list of all NIDPs by name for any given modality or atlas #' @param modality Neuroimaging modality. Defaults to NA; see README for additional options #' @param atlas Neuroimaging parcellation atlas for NIDP query. Defaults to NA; #' see README for additional options #' @param filename op...
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###Script 4 #Sctype to identify cell types # load libraries and functions lapply(c("dplyr","Seurat","HGNChelper"), library, character.only = T) source("https://raw.githubusercontent.com/IanevskiAleksandr/sc-type/master/R/gene_sets_prepare.R"); source("https://raw.githubusercontent.com/IanevskiAleksandr/sc-type/...
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--- title: "PSP GWAS genes in PSP brain" author: "Jack Humphrey" date: "06/03/2023" output: html_document --- ```{r setup, include=FALSE} knitr::opts_chunk$set(echo = TRUE) library(tidyverse) library(patchwork) ``` Cortex and Cerebellum RNA-seq from PSP cases and controls. ```{r fig.width = 10, fig.height = 10} ctx ...
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#' Cochrane review: summary of meta-analyses #' #' @description #' Calculate and print a summary of all meta-analyses in a #' Cochrane review. #' #' @param x An object of class \code{rm5}. #' @param comp.no Comparison number. #' @param outcome.no Outcome number. #' @param ... Additional arguments (passed on to \code{...
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library(data.table) library(synapser) library(magrittr) library(stringi) # array metadata: syn23569440 # login to synapse synapser::synLogin() # RNA expression metadata file rnaseq_meta <- fread(synGet("syn21088596")$path) rnaseq_meta <- rnaseq_meta[!is.na(RIN)][libraryPrep == "polyAselection"] # get metadata for a...
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source("code_utils/read_data/utils.R") source("code_utils/read_data/installation.R") install_libraries() library(SingleCellExperiment) library(rhdf5) library(tidyverse) library(Matrix) library(mclust) library(rjson) args = commandArgs(trailingOnly=TRUE) config_file_path <- args[1] params <- fromJSON(...
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#' Cluster information for MTG data set. #' #' Cluster information (including name, color, and type) for MTG data sets. #' #' @format A data frame with 75 rows and 11 variables: #' \describe{ #' \item{cluster_id}{cluster identifier} #' \item{cluster_label}{cluster name} #' \item{cluster_color}{cluster color in MT...
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--- title: "panel_Kv_toxin" author: "Franz Xaver Mittermaier" date: "2024-05-02" output: html_document --- This script creates the graph for the DTX-I experiments. In brief, I performed axonal bleb recordings. In voltage clamp mode I then performed the following protocol: Activation protocol: The bleb was hel...
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library(data.table) library(ggplot2) library(scales) dt = np_cpg_rna # tmem106B expression vs. LATE p_late_tmem = dt[ !is.na(TMEM106B) & !is.na(tdp_st4), ggplot( .SD, aes(x = factor(tdp_st4), y = log2(TMEM106B) + 1, fill = factor(tdp_st4), alpha = 0.2))] + geom_boxplot(outlier...
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# Auxiliary functions to transform relative treatment effects to # pairwise comparisons # # Author: Gert van Valkenhoef <gvanvalkenhoef@cochrane.org> # License: GPL (>= 2) # # For use with dplyr::group_map # pwgen_study <- function(input, studlab) { # Get rid of warning 'Undefined global functions or variables' tr...
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# Function ------------------------------------------------------------------- .scale <- function(x, center = TRUE, scale = TRUE) { validObject(x) if (!is.logical(center)) center <- as.matrix(center) if (!is.logical(scale)) scale <- as.matrix(scale) x@data$spc <- scale(x@data$spc, center, scale) x } #' C...
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# ======================================================== # Make tables of LDSC partitioned heritability results # The results files (.results) from the LDSC run should be organized # by annotation, with separate directories for each annotation. # Updated for the nonGC version # ===================================...
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library(ArchR) library(BSgenome.Mmulatta.UCSC.rheMac10) library(TFBSTools) library(JASPAR2020) addArchRThreads(threads = 8) rheMac10_UCSC = createGenomeAnnotation(genome='BSgenome.Mmulatta.UCSC.rheMac10') # Load Data adata = loadArchRProject('MacaqueBrain') # Add JASPAR2020 motifs PWM <- getMatrixSet( x = JASPAR...
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source('./scripts/01_Setup.R') setwd("./data/processed/rds") aa= grep("_gc_plot",list.files(), val=T) aa2= aa[aa%in%c("dMDA_101_500kb_gc_plot.rds", "Pico_76_500kb_gc_plot.rds", "Pico_101_500kb_gc_plot.rds", "PTA_48_500kb_gc_plot.rds", "PTA_101_500kb_gc_pl...
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library(data.table) library(stringi) nacc <- fread('data/adc/apoe_snps.raw') rosmap <- fread('data/rosmap/apoe_snps.raw') act <- fread('data/act/apoe_snps.raw') adni <- fread('data/adni/apoe_snps.raw') # covar <- fread('data/mega/mega_np.covar') nacc_covar = fread("data/adc/adc_np.covar") rosmap_covar = fread("data/r...
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#' @name DEPRECATED-spc.spline #' @concept deprecated #' #' @title (DEPRECATED) #' Spectral smoothing by splines #' #' @description #' #' These \pkg{hyperSpec} functions are **deprecated** and not maintained anymore. #' Currently they are present due to back-compatibility reasons and will be removed #' in the ne...
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## ##Performs perurbations to get p-values for lm ## lm.pert<-function(dat,form,perturbations="perturbations",batch="batch",numRep=1000,useBatch=F,dep_var="DPT",ref="",minPert=10,verbose=T) { dat=dat[!is.na(dat[,perturbations]),] lst=table(dat[,perturbations]) dat=dat[dat[,perturbations] %in% names(lst)[...
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#----Figure_06_G---------------------------------------------------------------- #------------------------------------------------------------------------------- # This is the code for Figure 06 Panel G for the connectivity analysis for # Reinhard and Fukuda et al. 2024 #-------------------------------------------...
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#' makeChipsMultiClass #' #' Deprecated. Use \code{\link{makeChips}} with \code{mode = "Positive"} instead. #' #' This function is a deprecated wrapper around \code{\link{makeChips}}. It #' will be removed in a future version. Replace calls of the form: #' #' \code{makeChipsMultiClass(image, mask, ...)} #' #' with: #' ...