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library("lme4") library("car") library("emmeans") # Selection of time window decoding method. classification_mode = "incremental" # "incremental", "sliding" if (classification_mode == "incremental") { cl_str = "tr" } else if (classification_mode == "sliding") { cl_str = "sl" } # Model 1: max decoding accuracy per d...
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R
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--- title: "Effect Directions" author: "Jack Humphrey" date: '2023-06-28' output: html_document --- ```{r setup, include=FALSE} knitr::opts_chunk$set(echo = TRUE) library(tidyverse) ``` ```{r} gwas <- read_tsv("data/farrell_psp_full_hits_1e6.tsv",col_names = c("chr", "end", "snp", "ref", "alt", "frq_a", "frq_u", "inf...
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R
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library(data.table) library(tidyverse) #net_cols <- c("#0072B2", "#009E73", "#D55E00", "#56B4E9", "#E69F00", "#F0E442", "#CC79A7") net_cols <- c("#009E73", "#E69F00", "#0072B2", "#F0E442", "#D55E00", "#56B4E9","#CC79A7") plt_out = '/data/project/ukb_reliability_in_prediction/plots/Figures/' # Empirical learning cu...
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R
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# @title normalization for mixed colors # Set generic ---------------------------------------------------------------- #' Normalize numbers to interval \[0, 1\] #' #' The input `x` is mapped to \[0, 1\] by subtracting the minimum and #' subsequently dividing by the maximum. If all elements of `x` are equal, #' 1 is ...
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R
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#remap genome if necessary... library(Seurat) library(dplyr) library(readr) library(Matrix) library(MatrixExtra) setwd(dirname(rstudioapi::getActiveDocumentContext()$path)) #need to find genome of all 3 experiments #need to make sure we're using the same gene list as them (25419 genes) #sathyamurthy: G...
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#' Groups are marked by colored rectangles as well as by their levels #' #' The dendrogram should be plotted separately, see the example. #' @title Mark groups in [stats::hclust()] dendrograms #' @param dendrogram the dendrogram #' @param groups factor giving the the groups to mark #' @param col vector with colors for ...
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R
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# Set generic ---------------------------------------------------------------- #' Function evaluation on `hyperSpec` objects #' #' Function `vanderMonde()` generates Vandermonde matrices, the `hyperSpec` #' method generates a `hyperSpec` object containing the Vandermonde matrix #' of the wavelengths of a `hyperSpec` o...
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R
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#' @name DEPRECATED-read.txt.Horiba #' @concept moved to hySpc.read.txt #' #' @title (DEPRECATED) #' Import Horiba Labspec exported ASCII files #' #' @description #' These data input functions are **deprecated** and they will be removed in #' the next release of \pkg{hyperspec} package. #' Now functions in packa...
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R
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#' Gene by NIDP summary plot of neuroimaGene object #' #' Generate overview plot of the neuroimagene object according to gene/NIDP pair #' @param ng_obj NeuroimaGene object #' @param maxGns maximum number of genes to visualize. default=15 #' @param maxNidps maximum number of NIDPs to visualize. default=20 #' @param tit...
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library(data.table) library(Biostrings) library(rhdf5) library(reshape2) library(beeswarm) h5dir = args[1] file1 = "Roadmap_FantomAnnotations.InputData.pM10Kb.txt.gz" file2 = "promoters_pM1.5Kb.FIMO_scanned.condensed.txt.gz" kmerlen = 4 if (grepl("Mouse",h5dir)) { file1 = "Mouse_FantomAnnotations.InputData.pM10K...
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# -------------------------------- # Load libraries and data # -------------------------------- library(rstudioapi) library(yaml) library(tidyr) library(dplyr) library(ggplot2) # Set working directory to script location setwd(dirname(rstudioapi::getActiveDocumentContext()$path)) # Load configuration config <- read_ya...
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R
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library(data.table) library(tidyverse) #net_cols <- c("#0072B2", "#009E73", "#D55E00", "#56B4E9", "#E69F00", "#F0E442", "#CC79A7") net_cols <- c("#009E73", "#E69F00", "#0072B2", "#F0E442", "#D55E00", "#56B4E9","#CC79A7") # EXTRA SUBS d_subsample = read_csv('/data/project//ukb_reliability_in_prediction/input/test-pi...
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#' Coerce to a data frame #' #' @description #' The \code{as.data.frame} method returns a data frame containing #' information on individual studies, e.g., estimated treatment effect #' and its standard error. #' #' @param x An object of class \code{meta}. #' @param row.names \code{NULL} or a character vector giving ...
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R
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library(ChIPseeker) library(ggplot2) library(clusterProfiler) library(TxDb.Hsapiens.UCSC.hg38.knownGene) library(DOSE) library(org.Hs.eg.db) txdb <- TxDb.Hsapiens.UCSC.hg38.knownGene #EZH2_3 ='SRX186720.05.bed' files <- c(REST_1 = 'SRX3010118.05.bed', REST_2 = 'SRX3010119.05.bed', EZH2_1 = 'SRX103...
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#' Predicts features' scores from a model #' #' Under development. This function is meant to predict #' the scores of features obtained from a trained model #' such as one returned by the 'reduce_*' family of functions. #' In particular, the function would ideally work with any #' technique implemented so far (PCA, rPC...
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# library(tidyverse) subs = read_csv('/home/mgell/Work/reliability/text_files/HCP_YA_subs.csv') tab = read_csv('/home/mgell/Work/reliability/text_files/HCP_YA_S1200_beh.csv') ages = read_csv('/home/mgell/Work/reliability/text_files/HCP_YA_restricted.csv') tab$Age_years = ages$Age_in_Yrs tab$Family_ID = ages$Famil...
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#' print top features for specific state #' @description print top features for specific state #' @param stateName cell state to print #' @param w1_file if set, stateName will be ignored #' @param myStateName state name of w1_file #' @param species human or mouse for now #' @param showN show n features #' @import dplyr...
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# Function ------------------------------------------------------------------- .dimnames <- function(x) { validObject(x) list( row = rownames(x@data), data = colnames(x@data), wl = colnames(x@data$spc) ) } #' Dimnames for `hyperSpec` objects #' #' `hyperSpec` objects can have row- and column nam...
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--- title: "panel_interleaved" author: "Franz Xaver Mittermaier" date: "2023-10-11" output: html_document --- This script plots the data panel that makes the point, that the analog signaling effect is a short-term effect. To achieve this, I use the interleaved protocols. In brief, I performed paired patch-clamp...
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### ----------------------------------------------------------------------------- ### ### write.txt.wide ### ### #' @rdname DEPRECATED-write_txt #' @concept deprecated #' #' @importFrom utils write.table #' @export write.txt.wide <- function(object, file = "", col...
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args <- commandArgs(trailingOnly = T) filenamex=as.character(args[[1]]) source('./scripts/01_Setup.R') all2= readRDS("./data/processed/rds/SignificantCells.rds") picocells_passing_mad_conf=all2 unique(picocells_passing_mad_conf$id) picocells_passing_mad_conf=picocells_passing_mad_conf$id Pico_76_SegFixed <- r...
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--- title: "panel_multi_up_down" author: "Franz Xaver Mittermaier" date: "2023-10-31" output: html_document --- This script plots the summary panel for the multi_up_down experiments. In brief, I performed paired whole-cell patch-clamp recordings of synaptically connected pyramidal neurons. I then used current ...
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#' viewBatch #' #' Generate image grid of mini-batch of image chips and associated masks created by a DataLoader. #' #' The goal of this function is to provide a visual check of a mini-batch of image chips and associated masks #' generated from a DataLoader. #' #' @param dataLoader Instantiated instance of a DataLoader...
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#BiocManager::install("fgsea") library(fgsea) library(dplyr) library(stats) library(ggplot2) setwd(dirname(rstudioapi::getActiveDocumentContext()$path)) data <- read.csv("../R/DESeq2/SDH_all/all_SDH_cells_sig_genes_nopseudo.csv") GO_file <- "../R/GSEA_data/msigdb_v2023.1.Mm_files_to_download_locally/msigdb_v...
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# Functions to load DADA2-output (based on the standard output) ######################## ## `create_tax_names` ## ######################## create_tax_names <- function(tax_table) { tax_names <- apply(tax_table, 1, function(x) { if(any(names(na.omit(x)) %in% "species")) { name <- str_c(tail(na.omit(x), 2),...
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#' mochims__define_confident_free_energies #' #' Call confident ddGs. #' #' @param input_dt data.table with model free energy estimates (required) #' @param report_outpath output path for scatterplots (required) #' @param highlight_colour colour for highlights (default:red) #' @param energy_max_ci maximum energy confi...
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--- title: "Causal Conditional Distance Correlation" author: "Eric W. Bridgeford" date: "`r Sys.Date()`" output: rmarkdown::html_vignette vignette: > %\VignetteIndexEntry{cb.detect.caus_cdcorr} %\VignetteEngine{knitr::rmarkdown} %\VignetteEncoding{UTF-8} --- ```{r setup, include = FALSE} knitr::opts_chunk$set( ...
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--- title: "20230411_puncta_circularity" output: html_document date: "2023-04-11" --- ```{r setup, include=FALSE} knitr::opts_chunk$set(echo = TRUE) ``` ```{r load packages} #loaded RStudioAPI to use for selecting working directory if("rstudioapi" %in% rownames(installed.packages()) == FALSE) {install.packages("rstu...
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#' Plot a 3D scatterplot (based on plot3D) based on a reduce_rPCA object #' #' This function is under active development. It is #' meant to depict the three scores of components obtained by reducing #' pupillary time-series through rPCA. #' There are some strong assumptions, first and foremost that the object is #' fro...
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# BIL Paper figure 5: showing what data is available (datasets, techniques, species) library(ggplot2) library(dplyr) library(forcats) library(pals) ## load file from BIL inventory sum <- read.csv("summarymetadata.csv") ## manual clean of metadata ### species { sum[sum == 'mouse'] <- 'Mouse' sum[sum == 'marmoset'] <- ...
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# FNIH Project 2 # make AUC Forest plots #### Coded: Kellen Petersen #### Date as of commenting and documentation - 05/31/2024 # Load libraries library(tidyverse) library(data.table) library(RVAideMemoire) library(pROC) library(RColorBrewer) library(MuMIn) library(here) library(cowplot) library(ggeasy) library(scales)...
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#' @title Run consensus1 #' @description Using consensus1 method to clust single cell data. #' @param norm.dat Single cell expression data input. #' @param select.cells Numeric, use all or part of the cells for clustering, cells can be sampled to save running time in multi-round clustering. Using all cells by defau...
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#' mochims__pairwise_distances_from_PDB #' #' Calculate pairwise (side-chain) heavy atom distances or minimum thereof. #' #' @param input_file path to PDB file (required) #' @param chain_query query chain id (default:A) #' @param chain_target target chain id (default:B) #' @param min_dist minimum distance (default:TRU...
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# Load and install missing packages --------------------------------------- packages <- c("devtools", "Seurat") package.check <- lapply( packages, FUN = function(x) { if (!require(x, character.only = TRUE)) { install.packages(x, dependencies = TRUE) library(x, character.only = TR...
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#rm(list=ls()) # alzheimer data library(dplyr) library(SummarizedExperiment) # reading data sets phe = read.csv2(data.makepath("/ADNI/ADNI_datasets_from_Matthias/adni1go2.phenotypes.covariates.csv"), na.string="NA",header=T,sep=",",dec = ".") bba = read.csv2(data.makepath("/ADNI/ADNI_datasets_from_Matthias/adni1go2....
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#' generate_type2_data #' #' This function generates data and plots for selected clusters. #' #' @param meta_data_file Path to the metadata file. #' @param gene_count_file Path to the gene count file. #' @param selected_clusters A named vector specifying the clusters to include. #' @param Prefix Prefix for the output C...
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# If you need the original fragment files for quality control analysis, please contact: wuhaixu@mail.kiz.ac.cn library(ArchR) addArchRThreads(threads = 8) addArchRGenome("hg38") # Create ArchR Arrow Files pathFragments = '../../Data/Human' inputFiles = c('../../Data/Human/Human_fragments.tsv.gz') names(inputFiles) =...
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#' Calculation of confidence intervals (based on normal approximation #' or t-distribution) #' #' @description #' Calculation of confidence intervals; based on normal approximation #' or t-distribution. #' #' @param TE Estimated treatment effect. #' @param seTE Standard error of treatment estimate. #' @param level Th...
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library(caret) library(ggplot2) library(plotly) library(dplyr) library(ggpubr) library(ROCR) #You will need to put the probabilites from your own path Y<-data.frame(class = as.factor( c( rep("Sweep", 1000), rep("Neutral", 1000) ) ) ) df <- read.csv(paste0("Filename_and_directory_for_readling_wavelet_probabilities"),h...
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library(Seurat) library(dplyr) library(ggplot2) # Map clinical data to the metadata merge_metadata <- function(sobj, metadata){ meta_data_sex <- inner_join(sobj@meta.data, metadata) rownames(meta_data_sex) <- rownames(sobj@meta.data) sobj@meta.data <- meta_data_sex return(sobj) } # Assign the AD variable ...
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suppressPackageStartupMessages(library(dplyr)) suppressPackageStartupMessages(library(ggplot2)) suppressPackageStartupMessages(library(ggridges)) ## set _DEBUG_PARAMS = True in resquiggle.py ## example run for min_obs_per_base testing: ##for i in {0..2}; do ## testParam=`echo $i | awk '{print ($1 * 1) + 1}'` ## ...
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#' Convenience function to check series across IDs and Trials, and save a plot in the current path #' #' Convenience function to check series across IDs and Trials, which saves multiple #' plots in the current path by creating folders and subfolders in a hopefully #' meaningful way. #' Note that with massive data this ...
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#Using matlab fname='/scratch/mshruv003/visium_08_10_21/Hockman_Visium/X201SC21082979-Z01-F001_01/raw_data/Visto/15_yr_old_DH1.tif'; N=5; VNS(fname,N) fname='/scratch/mshruv003/visium_08_10_21/Hockman_Visium/X201SC21082979-Z01-F001_01/raw_data/Visto/15_yr_old_DH1.tif'; M=5; refineVNS(fname,M) mask='/scra...
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```{r load-config, incluse=FALSE} source("config.R", local = knitr::knit_global()) ``` ```{r import-patients} df_patient = read.csv("data/msb_patient.csv") sprintf("Number of rows in patient datatable: %d", nrow(df_patient)) ``` ```{r echo=FALSE} table(df_patient["MSCOURSE_2"]) ``` ```{r select-patients} # Select R...
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#' mochims_coefficient_size_distribution #' #' Coupling scatterplots. #' #' @param input_file path to MoCHI thermo model fit results (required) #' @param outpath output path for plots and saved objects (required) #' @param colour_scheme colour scheme file (required) #' #' @return Nothing #' @export #' @import data.tab...
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test_that("metagen three-level robust example runs", { skip_if_not_installed("metadat") data(dat.konstantopoulos2011, package = "metadat") dat <- dat.konstantopoulos2011 dat$idx <- seq_len(nrow(dat)) ma <- metagen(yi, sqrt(vi), studlab = study, data = dat, sm = "SMD", ...
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assign_levels <- # Takes UKB raw data and assigns the right labels to vactors function(bd) { # Reported sex lvl.0009 <- c(0, 1) lbl.0009 <- c("Female", "Male") bd$f.31.0.0 <- ordered(bd$f.31.0.0, levels = lvl.0009, labels = lbl.0009) # Genetic sex bd$f.22001.0.0 <- ordered(bd$f.22001.0.0, l...
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library("lmerTest") library("multcomp") library("emmeans") library("readxl") options(max.print=1000000) NEW_DATA$Injury = as.factor(NEW_DATA$Injury) NEW_DATA$Time = as.factor(NEW_DATA$Time) NEW_DATA$Mouse = as.factor(NEW_DATA$Mouse) results = lmer(Amplitude ~ Injury * Time + (1|Mouse), data = NEW_DATA) anova(results,...
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#' Helper Function to Harmonize Treatment of File Import Results #' #' This function provides two ways of post-processing imported spectra: #' #' - optionally remove empty spectra (some spectrograph software will produce #' empty spectra when measurements are cancelled) #' - optionally keep the filenames in column `s...
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source('./scripts/01_Setup.R') all2= readRDS("./data/processed/rds/SignificantCells.rds") picocells_passing_mad_conf= all2$id Pico_76 <- readRDS("./data/processed/rds/PTA_48_500kb_lift_SegFixed_cnv_stat_genome.rds") Pico_76x= Pico_76[Pico_76$id%in%picocells_passing_mad_conf,] Pico_76x= Pico_76x[!Pico_76x$chr%in%c('chr...
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# -------------------------------- # Load libraries and data # -------------------------------- library(rstudioapi) library(yaml) library(dplyr) library(ggplot2) # Set working directory to script location setwd(dirname(rstudioapi::getActiveDocumentContext()$path)) # Load configuration config <- read_yaml("statistics_...
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#' @rdname palettes #' @aliases palette_matlab colors,palette_matlab #' #' @title Matlab-like color palettes #' #' @description #' Two palettes going from blue over green to red, approximately as the #' standard palette of Matlab does. The second one has darker green values and #' is better suited for plotting lines on...
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# Copyright 2022 HYBRID Team INCIA, UMR5287, CNRS, Université de Bordeaux # Licensed under the Apache License, Version 2.0 (the "License"); # you may not use this file except in compliance with the License. # You may obtain a copy of the License at # http://www.apache.org/licenses/LICENSE-2.0 # Unless required b...
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# Formulas to fit formula_unadj <- function(outcome, SNP, dual_delivery = FALSE) { if (dual_delivery) { formula(paste(outcome, "~", SNP, "+ delivery")) } else { formula(paste(outcome, "~", SNP)) } } formula_age_sex <- function(outcome, ...
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# The contents of "read.ENVI.Nicolet.R" read.ENVI.Nicolet <- function( file = stop("read.ENVI: file name needed"), headerfile = NULL, header = list(), ..., # goes to read.ENVI x = NA, y = NA, # NA means: use the specifications from the header file if possible nicolet.correction = FALSE) { ## the additi...
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library(geodl) setwd("Your Working Directory") # Accuracy Assessment Examples -------------------------------------------- #Example 1: table that already has the reference and predicted labels for a multiclass classification #Read in table mcIn <- readr::read_csv("data/tables/multiClassExample.csv") #Calc...
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library(data.table) library(ordinal) library(MASS) library(readxl) rosmap_clin <- setDT(read_xlsx("/data_global/ROSMAP/greg_20200109/dataset_843_basic_01-09-2020.xlsx")) ###### CpG ##### load("data/cpg.RData") cpg = cpg[, .(IID, specimenID, conversion.efficiency, cg09613507, cg23422036)] np_cpg = merge(rosmap_clin, c...
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library(ROCR) #### MOUSE ###### a=read.delim("all_crossvalidated_predictions_mESC.txt") b=read.delim("all_crossvalidated_predictions_mouse.txt") colnames(a)[2:3]=c("mESCPred","mESCActual") a=merge(a,b,by=1) a[a=='']="NA" mouse = a ### HUMAN ##### a=read.delim(gzfile("57epigenomes.RPKM.pc.gz")) a$E000=NULL a[,2:ncol...
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rm(list=ls()) library(segmented) library(ggplot2) library(extrafont) library(drc) library(nlme) library(R.matlab); library(mgcv); library(visreg); project_path = 'G:'; rCBF_mat_path = paste0(project_path,'/rCBF.mat'); rCBF = readMat(rCBF_mat_path); age_mat_path = paste0(project_path,'/age.mat'); age = readMat(age_mat_...
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#' Region-of-Interest mapping object #' #' A class for surface vertices mapping on atlas labels #' #' @slot data A matrix object with N vertices from a template and each parcellation number the vertices correspond to in 6 atlases (6 columns). #' @slot atlases Each of the 6 available atlases and their corresponding ...
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library(dplyr) library(tidyr) library(ggplot2) # Parse and check inputs args <- commandArgs(trailingOnly = TRUE) print(args) if (length(args) < 3) { print("Requires arguments 1=Directory, 2=SampleId, 3=MsStatsTableFile") stop() } outDir <- args[1] sampleId <- args[2] msStatsTableFile <- args[3] if (!file.exists...
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#' Auxiliary functions to calculate the dimensions of a forest plot #' #' @description #' Extracts the exact width and height of a `meta` forest plot from its internal #' grid layout. This is primarily used to determine the optimal dimensions for #' saving the forest plot to a file. #' #' @details #' Rather than using...
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library(natverse);library(reticulate);library(neuprintr); library(hemibrainr); library(nat); library(natverse); library(nat.jrcbrains); library(fafbseg); setwd(getSrcDirectory(function(){})[1])# set the working directory to where this code is source("Connectomics_functions.R")#library(RConnectomicsAnalysis) # # ###...
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#/bin/Rscript # # This script will run Genomic SEM on example data # and will generate Q indeces. # Prep library(GenomicSEM) # load LDSC load("/path/to/dir/GenomicSEM_LDSCoutput_dys_rhyimp.RData") # here set the path # 1) Common Pathway Model model = "F1 =~ 1*Dyslexia + 1*Rhythm_impairment F1 ~ SNP Dyslexia ~~ a*Dysl...
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#' Plot all (three) fingerprints of reduced time-series #' #' This function is under active development. It is #' meant to depict the three eigenvectors/loadings/weights of components obtained by reducing #' pupillary time-series, as to ease interpretation. Note that the #' components and their names are re-ordered acc...
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setwd("XXX") set.seed(42) library(limma) # import raw counts_mat = read.delim("PATH_TO_COUNTS") meta = read.delim("PATH_TO_METADATA") # should contain: PRS, tx, line ## sanity check # all.equal(rownames(meta), colnames(counts_mat)) # init DGE list x <- DGEList(counts_mat) ## update sample info all.equal(rownames(x$...
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# In this script we are creating a heatmap for the correlations between species abundance and GBM abundance in the dataset library(tidyverse) library(here) library(Hmisc) library(corrplot) library(car) #read in the gut-brain modules file gbms <- read.csv(here("processed_data", "shotgun", "functional_other", "GBMs_KE...
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require(energy) require(cdcsis) require(causalBatch) require(sva) require(GeneralisedCovarianceMeasure) # Conditional distance correlation from Wang et al., 2015 cond.dcorr <- function(Ys, Ts, Xs, R=1000, dist.method="euclidean", distance = FALSE, seed=1, num.threads=1) { Xs <- as.data.frame(Xs) if (isTRUE(dist...
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require(data.table) source("bin/All_Classes.R") source("bin/obsolete.R") source("bin/ora.R") source("bin/heatmap.R") source("bin/pca.R") source("bin/tokenization.R") #source("bin/differential_expression.R") #source("auth/auth.R") # Upload dataset ---- convertColumns <- c("UNIPROTID", "ENTREZID", "SYMBOL", "GENEID",...
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### ----------------------------------------------------------------------------- ### ### read_txt_wide ### ### Format: ### x y ... int (wl1) int (wl2) ... int (wl p) z ... ### #' Import/export of `hyperSpec` objects to/from ASCII files #' #' @details #' A detailed discussion of \pkg{hyperSpec}'s file import and e...
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### Regulatory landscapes ### ### Figure 4 ### library(GeneOverlap) library(matrixStats) REGtable <- read_excel("UU Dropbox/Ida Larsson/scTargetTranslator/revision/manuscript/supplement/supplementary_20240912/SourceData.xlsx", sheet = "Figure 4B") REGtable <- as.data.frame(REGtable) rownames(REGtable)<-REGtable[,1] R...
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--- title: "panel_depol_hyperpol" author: "Franz Xaver Mittermaier" date: "2023-04-10" output: html_document --- This script creates the panel for the 'Depol+Hyperpol' paradigm. In brief, I performed paired patch-clamp recordings of synaptically connected pyramidal neurons. I then used presynaptic current injec...
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#This script processes a TIFF image file containing multiple frames. It reads the frames, #performs thresholding to create binary images, and calculates the fraction of overlapping #pixels between two measures (fm and sa). It then plots these fractions over time and saves #the results to a text file. The use of t...
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#' @param new Name of replacement function. #' @param package Name of the package the function is moved to. #' @param url Homepage of the package. #' @param old Function that is replaced #' #' @keywords internal #' @noRd hySpc_deprecated <- function(new = "", package = NULL, url = NULL, o...
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# Function ------------------------------------------------------------------- .sweep <- function(x, MARGIN, STATS, FUN = "-", check.margin = TRUE, ...) { validObject(x) if (is(STATS, "hyperSpec")) { validObject(STATS) STATS <- STATS@data$spc } else if (is(STATS, "function")) { ST...
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--- title: "Cell cycle scoring and UMAP generation" output: html_document: df_print: paged --- In this script, we use the CellCycle Scoring function of Seurat, generate a UMAP and cluster cells together. ```{r Librairies} library(tidyverse) library(dplyr) library(clustree) library(patchwork) library(Seurat, lib...
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args <- commandArgs(trailingOnly = T) filenamex=as.character(args[[1]]) source('./scripts/01_Setup.R') raw_dMDA_5Mb = read.table(file.path('./data/processed',filenamex, 'data'), header=TRUE, sep="\t") saveRDS(raw_dMDA_5Mb, file = file.path('./data/processed/rds', paste0('raw_', filenamex, '.rds'))) CNV1= read.table...
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--- title: "Direction of effect of FADS2 genotype on traits with a statistically significant main effect" author: "Giulio Centorame" date: "`r Sys.Date()`" output: rmdformats::downcute: toc: 6 number_sections: yes --- The aim of this notebook is to compare the direction of effect of traits with a statistical...
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#' Annual Accumulated Growing Degree Days (°C) from SAGE #' #' A `raster` containing annual global accumulated growing degree days (°C) for the year with a base temperature of 5°C. #' #' @format An object of class `RasterLayer`. #' @source \url{https://sage.nelson.wisc.edu/data-and-models/atlas-of-the-biosphere/mapping...
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library(data.table) library(magrittr) `%!in%` <- function(x, v) {!(x %in% v)} pheno_ord <- fread("data/mega/mega_np_ord.pheno", na.strings = '-1') pheno_bin <- fread("data/mega/mega_np.pheno") phenotypes_ord <- colnames(pheno_ord)[3:ncol(pheno_ord)] phenotypes_bin <- colnames(pheno_bin)[3:ncol(pheno_bin)] phenotypes <...
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--- title: "TWAS_plot" output: pdf_document --- ```{r setup, include=FALSE} knitr::opts_chunk$set(echo = TRUE) library(biomaRt) library(qqman) library(dplyr) ``` ```{r readData} twas_all_fdr = read.table("/data/clusterfs/lag/users/gokala/beat-dyslexiaevol/results/TWAS/twas_FDRall_results.csv", header = T) ``` ```{r ...
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##------------------------------------------- ## Pull mRNA expression data from Synapse ## and prepare for analysis ##------------------------------------------- library(data.table) library(magrittr) library(stringi) ##----------------------------------------------------- ## Connect the specimenIDs in RNA expression...
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library(WGCNA) multiExpr = vector(mode="list", length=2) multiExpr[[1]] = list(data=as.data.frame(t(CAU_datExpr[genes,]))) multiExpr[[2]] = list(data=as.data.frame(t(CNS_datExpr[genes,]))) #multiExpr[[3]] = list(data=as.data.frame(t(AA_datExpr[genes,]))) bsize = 5000 nSets = 2 #nSets = 3 powers = c(seq(1,19,by=1),seq(...
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# File: get_pars.R # Author: Kelly Chang # Date: Oct 2017 # Version: 1.0 # # Description: Helper R function that returns the model parameters for a # specified simulation type (e.g. control, drug with fixed # inputs, drug with uncertainty inputs, etc.). # get_pa...
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##---------------------------------------------- ## create PCA plot of 1KG and adc NP subjects ##---------------------------------------------- library(pacman) p_load(data.table, magrittr, ggplot2) # groundhog.library("ggplot2", day) # 1000g (otg) data population data otg <- fread("/data_global/1000g/integrated_call_...
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require(ks) test_that("k-way matching with one odd-ball per-group", { nrep <- 100 res <- sapply(1:nrep, function(i) { Ts <- c(rep(1, 100), rep(2, 100)) Xs <- cbind(c(-4, runif(198), 5), c(-4, runif(198), 5), runif(200)) retained.ids <- suppressWarnings(cb.align.kway_match(Ts, data.frame(Covar=X...
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library(rstatix) library(ggplot2) library(ggpubr) library(openxlsx) library(dplyr) library(RColorBrewer) library(wesanderson) library(lme4) library(nparLD) library(lmerTest) library(jtools) # Read the data data = read.csv('../fMRI analysis/deltas.csv')[,2] threshold = median(data) group = ifelse(data>...
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--- title: "pre_drive_post_histogram" author: "Franz Xaver Mittermaier" date: "2023-06-28" output: html_document --- I performed multineuron patch-clamp recordings to identify convergent microcircuit-motifs. I then induced a 'Control' and a 'Depol+Hyperpol' condition followed by a train of 5 APs. I injected cur...
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# This script will run Model Averaged GWAMA on dyslexia and rhythm GWAS sumstats. # # Gokberk Alagoz - 04.03.22 # #----- # Libraries source("https://github.com/baselmans/multivariate_GWAMA/blob/master/Test_Data/N_weighted_GWAMA.function.1_2_6.R?raw=TRUE") library(data.table) library(sp) library(rater) library(RcppArmad...
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## ----------------------------------------------------------------------------- ## ## Somatic variant detection in lesional focal epilepsy ## Depmap functional analysis; pairwise co-dependency ## ref: Gatto et al. 2023; Shimada et al. 2021 ## ## Author: Dr. Christian Bosselmann ## ## Date Created: 2023-09-05 ## ## Cop...
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##---------------------------------------------- ## create PCA plot of 1KG and adc NP subjects ##---------------------------------------------- library(pacman) p_load(data.table, magrittr, ggplot2) # groundhog.library("ggplot2", day) # 1000g (otg) data population data otg <- fread( "/data_global/1000g/integrated_ca...
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#### Markos et al 2024 #### Script used for analysis of 10X matrices #### Prechordal plate vs Notochord markers # load prerequisities library(Seurat) library(patchwork) library(ggplot2) # load output of AmphiN0stage.R AmphiN0stage <- readRDS("../timepoints_rds/Amp_N0.RDS") DimPlot(AmphiN0stage, reduction = "umap", p...
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suppressPackageStartupMessages(library(rrvgo)) suppressPackageStartupMessages(library(org.Hs.eg.db)) suppressPackageStartupMessages(library(mgsub)) suppressPackageStartupMessages(library(ggforce)) suppressPackageStartupMessages(library(ggpubr)) suppressPackageStartupMessages(library(ggridges)) suppressPackageStartupMes...
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#'@title run.multitest #'@description #'calls DEGage for every comparison necessary in the DEGage_complete workflow #' #'@param allcounts the entire matrix of counts for all cells #'@param counts A dataframe with cells as columns and genes as rows. #'@param group A factor which assigns conditions to cells as in D...
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#Data for the supplement cor_boney_wm <- bones_ukb_WM %>% dplyr::filter(eid %in% old_id$eid) cor_boney_wm <- cor_boney_wm%>%dplyr::select( eid, sex, age, sit_height, VAT, ASAT, fat_percent, BMI, BMD_head, BMD_total, T_BMD_total, femur_BMD, ...
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--- title: "power_analysis" author: "mjp" date: "6/2/2021" output: html_document editor_options: chunk_output_type: console --- ```{r setup, include=FALSE} knitr::opts_chunk$set(echo = TRUE) ``` ```{r setup, include=FALSE} knitr::opts_chunk$set(echo = TRUE) setwd('/mnt/data/peaky_pitch/') easypackages::libraries...
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# Function ------------------------------------------------------------------- .Compare_hh <- function(e1, e2) { validObject(e1) validObject(e2) callGeneric(e1[[]], e2[[]]) } #' @title Comparison of `hyperSpec` objects #' #' @description #' The comparison operators `>`, `<`, `>=`, `<=`, `==`, and `!=...
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# format METAL results for downstream work #!/usr/bin/env Rscript --vanilla # Load the required packages library(data.table) library(stringi) library(argparse) # function for flipping direction of effect in Direction column (e.g. "++-" -> "--+") flip_effect_directions_fast <- function(directions_vector) { # Tempor...
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#### Notes #### #### Libraries #### library(colorBlindness) #### Sourced functions #### #### Functions #### # Permute values in each column permute_by_cols <- function(input.matrix, seed=12345) { set.seed(seed) permuted.matrix <- input.matrix for (s in colnames(input.matrix)) { permuted.matrix[,s] <- ...
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soft_power_thresholds <- c(seq(4, 9, by = 1), seq(10, 50, by = 5)) library(Seurat) library(WGCNA) library(hdWGCNA) library(progressr) library(foreach) # Will be the dataset "wang" or "pbmc" dataset <- commandArgs(trailingOnly = TRUE)[1] output_path <- "output" library(data.table) source("../utils/0-indices.R") cou...