id stringlengths 11 14 | sentence1 stringlengths 20 192 | sentence2 stringlengths 50 19.2k | label stringclasses 2
values |
|---|---|---|---|
converted_274 | Is single-cell analysis (SCA) possible in proteomics? | Toward Single Cell Analysis by Plume Collimation in Laser Ablation Electrospray Ionization Mass Spectrometry., he advent of proteomics and genomics at a single-cell level has set the basis for an outstanding improvement in analytical technology and data acquisition., The new-generation technology of single-cell analysi... | no |
converted_2669 | Is CXCL7 a chemokine? | CXCL7, a chemokine highly expressed in platelets, , Chemokine CXCL7 Heterodimers | yes |
converted_3871 | Is Olaparib effective for prostate cancer? | We hypothesized that metastatic, castration-resistant prostate cancers with DNA-repair defects would respond to poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibition with olaparib.METHODS: We conducted a phase 2 trial in which patients with metastatic, castration-resistant prostate cancer were treated w... | yes |
converted_3498 | Has ProSavin undergone phase IV clinical trials by 2018? | Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial., We undertook a phase 1/2 open-label trial with 12-month follow-up at two study sites (France and UK) to assess the safety and efficacy of ProSavin after bilater... | no |
converted_4024 | Is the apilimod inhibitor effective against SARS-CoV-2? | To identify therapeutics that can be repurposed as SARS-CoV-2 antivirals, we profiled a library of known drugs encompassing approximately 12,000 clinical-stage or FDA-approved small molecules. Here, we report the identification of 30 known drugs that inhibit viral replication. Of these, six were characterized for cellu... | yes |
converted_1055 | Does splicing occur co-transcriptionally? | Researchers working in multiple model organisms - notably yeast, insects and mammalian cells - have shown that pre-mRNA can be spliced during the process of transcription (i.e. co-transcriptionally), as well as after transcription termination (i.e. post-transcriptionally), The consensus view, based on four organisms, i... | yes |
converted_3916 | Is HbA1c an ideal biomarker of well-controlled diabetes? | HbA1c is a biomarker with a central role in the diagnosis and follow-up of patients with diabetes, although not a perfect one. Common comorbidities encountered in patients with diabetes mellitus, such as renal insufficiency, high output states (iron deficiency anaemia, haemolytic anaemia, haemoglobinopathies and pregna... | no |
converted_249 | Does burning mouth syndrome preferentially affect post-mepopausal women? | It is observed principally in middle-aged patients and postmenopausal women and may be accompanied by xerostomia and altered taste., It occurs more commonly in middle-aged and elderly women and often affects the tongue tip and lateral borders, lips, and hard and soft palate. , BMS is a chronic disorder that frequently ... | yes |
converted_4667 | Is Ameloblastoma (AB) a common benign tumor occurring in the brain? | Ameloblastoma is a benign odontogenic tumor which undergoes malignant transformation to ameloblastic carcinoma. , Ameloblastomas are benign tumors that most commonly affecting the mandible. , Ameloblastoma is a neoplasm arising in the craniofacial skeleton., Ameloblastoma is an invasive odontogenic tumor, and for recon... | no |
converted_46 | Are there web based self management strategies for chronic pain ? | Fibromyalgia Symptom Reduction by Online Behavioral Self-monitoring, , This study aimed to evaluate effects of a web-based, self-monitoring and symptom management system (SMARTLog) that analyzes personal self-monitoring data and delivers data-based feedback over time., Moderate use (3 times weekly x 3 months) increased... | yes |
converted_3222 | Is Pim-1 a protein phosphatase? | Pim-1 proto-oncogene, serine/threonine kinase (PIM-1) phosphorylates a series of substrates to exert its oncogenic function in numerous malignancies., The Pim1 serine/threonine kinase is associated with multiple cellular functions including proliferation, survival, differentiation, apoptosis, tumorigenesis, immune regu... | no |
converted_163 | Does MicroRNA-21 (miR-21) contribute to cardiovascular disease? | The synergistic effect of miR-21 and miR-1 were functionally validated for their significant influences on myocardial apoptosis, cardiac hypertrophy and fibrosis., Taken together, we found a novel reciprocal loop between miR-21 and TGFβRIII in cardiac fibrosis caused by myocardial infarction in mice, and targeting this... | yes |
converted_2184 | Is hydroxyurea usually used to treated infectious disease? | Hydroxyurea represents the only available disease-modifying therapy for SCA, and has proven safety and efficacy in high-resource countries, In conclusion, the data here presented suggests that hydroxyurea may prevent priapism attacks in sickle cell disease, probably at higher doses than usually prescribed for painful c... | no |
converted_2282 | Is dasatinib effective for treatment of glioblastoma? | RESULTS: fourteen randomized clinical trials were identified (7 with bevacizumab, 2 cilengitide, 1 enzastaurin, 1 dasatinib, 1 vandetanib, 1 temsirolimus, 1 cediranib) including 4330 patients. Antiangiogenic drugs showed no improvement in overall survival with a pooled HR of 1.00, a trend for an inferior outcome, in te... | no |
converted_1613 | Do plant genomes contain CpG islands? | This study represents the first systematic genome-scale analysis of DNA curvature, CpG islands and tandem repeats at the DNA sequence level in plant genomes, and finds that not all of the chromosomes in plants follow the same rules common to other eukaryote organisms, suggesting that some of these genomic properties mi... | yes |
converted_2004 | Are there methods for generating highly multiplexed ChIP-seq libraries? | A method for generating highly multiplexed ChIP-seq libraries., The barcoding of next generation sequencing libraries has become an essential part of the experimental design. Barcoding not only allows the sequencing of more than one sample per lane, but also reduces technical bias. However, current barcoding strategies... | yes |
converted_1177 | Could bioprinting be used in regenerative medicine against bone disease? | Before 3D Printing can be used routinely for the regeneration of complex tissues (e.g. bone, cartilage, muscles, vessels, nerves in the craniomaxillofacial complex), and complex organs with intricate 3D microarchitecture (e.g. liver, lymphoid organs), several technological limitations must be addressed. , It is expecte... | yes |
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