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converted_540 | Is Calcium homeostasis important in cardiac physiology and pathophysiology? | Maintenance of cellular calcium homeostasis is critical to regulating mitochondrial ATP production and cardiac contraction. , the Ca(2+) signal regulates the most important activities of the cell, from the expression of genes, to heart and muscle contraction and other motility processes, to diverse metabolic pathways i... | yes |
converted_980 | Is there a relationship between junctin and ryanodine receptors? | Junctin, a 26 kDa intra-sarcoplasmic reticulum (SR) protein, forms a quaternary complex with triadin, calsequestrin and the ryanodine receptor (RyR) at the junctional SR membrane. , Junctin ablation appears to affect how RyRs 'sense' SR Ca(2+) load, resulting in decreased diastolic SR Ca(2+) leak despite an elevated [C... | yes |
converted_3238 | Do tumour-associated macrophages have a prognostic role in gliomas? | Increasing evidence suggests that tumour-associated macrophages/microglia (TAMs) facilitate tumour progression by acquiring a M2-like phenotype. Our objective was to investigate the prognostic value of TAMs in gliomas using automated quantitative double immunofluorescence., This is the first study to use automated quan... | yes |
converted_2953 | Has ivosidenib been FDA approved for use against acute myeloid leukemia? | The FDA approved ivosidenib for patients with IDH1-mutant relapsed/refractory acute myeloid leukemia. | yes |
converted_506 | Are there conserved noncoding elements identified between genomes of human and teleosts? | We report evidence for a mechanism for the maintenance of long-range conserved synteny across vertebrate genomes. We found the largest mammal-teleost conserved chromosomal segments to be spanned by highly conserved noncoding elements (HCNEs), their developmental regulatory target genes, and phylogenetically and functio... | yes |
converted_2947 | Are there tools for reviewing variant calls? | VIPER: a web application for rapid expert review of variant calls., With the rapid development in next-generation sequencing, cost and time requirements for genomic sequencing are decreasing, enabling applications in many areas such as cancer research. Many tools have been developed to analyze genomic variation ranging... | yes |
converted_2709 | Is lumican a secreted protein? | fibroblasts stimulated with the fibrocyte-secreted inflammatory signal tumor necrosis factor-α secrete the small leucine-rich proteoglycan lumican, TNF-α-stimulated fibroblasts secrete lumican to promote fibrocyte differentiation., Secreted 70kDa lumican stimulates growth and inhibits invasion of human pancreatic cance... | yes |
converted_969 | Are Sidekick proteins members of the immunoglobulin superfamily? | Here we show that four closely related immunoglobulin superfamily (IgSF) adhesion molecules--Dscam (Down's syndrome cell adhesion molecule), DscamL (refs 6-9), Sidekick-1 and Sidekick-2, Sidekick-1, a cell adhesion molecule of the immunoglobulin superfamily, is up-regulated in glomerular podocytes in the collapsing glo... | yes |
converted_2223 | Are selenium supplements recommended for prostate cancer prevention? | Our meta-analysis in prospective studies demonstrated a significant inverse association between selenium status and CVD risk within a narrow selenium range and a null effect of selenium supplementation on CVD was observed in RCTs. These findings indicate the importance of considering selenium status, dose and safety in... | no |
converted_2280 | Is enzastaurin effective treatment of glioblastoma? | RESULTS: fourteen randomized clinical trials were identified (7 with bevacizumab, 2 cilengitide, 1 enzastaurin, 1 dasatinib, 1 vandetanib, 1 temsirolimus, 1 cediranib) including 4330 patients. Antiangiogenic drugs showed no improvement in overall survival with a pooled HR of 1.00, a trend for an inferior outcome, in te... | no |
converted_4229 | Has FTY720 been considered for the treatment of stroke? | FTY720 (Fingolimod) Ameliorates Brain Injury through Multiple Mechanisms and is a Strong Candidate for Stroke Treatment, Many researchers have recognized the positive effects of FTY720 and launched basic and clinical experiments to test the use of this agent against stroke. Although the mechanism of FTY720 has not been... | yes |
converted_1465 | Does triiodothyronine (T3) has cardiac angiogenic effects? | T3-induced cardiac sprouting angiogenesis in adult hypothyroid mice was associated with PDGF-BB, PDGFR-β and downstream activation of Akt., L-T3 significantly increased angiogenesis and cell survival and enhanced the expression of nuclear-encoded transcription factors involved in these processes., T(3) administration r... | yes |
converted_3947 | Is there a link between rare variants in PPARG and type 1 diabetes? | Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes., By sequencing PPARG in 19,752 T2D cases and controls drawn from multiple studies and ethnic groups, we identified 49 previously unidentified, nonsynonymous PPARG variants (MAF < 0.5%). Con... | no |
converted_2787 | Is cohesin linked to myeloid differentiation? | Consistent with a role for inflammatory signals in promoting myeloid differentiation of hematopoietic stem and progenitor cells (HPSCs), cohesin mutations in HSPCs led to reduced inflammatory gene expression and increased resistance to differentiation-inducing inflammatory stimuli. These findings uncover an unexpected ... | yes |
converted_2491 | Has ATF4 transcription factor been linked to cancer and neoplastic transformation? | aken together, we discovered a novel axis of BCL10-regulated OSCC progression via STAT1/ATF4/S100P/P65 signaling, which could predict the prognosis of OSCC and will be beneficial for developing therapeutic strategy against advanced OSCC, s a result, the level of phosphorylated Eukaryotic Initiation Factor 2 alpha (eIF2... | yes |
converted_2916 | Is there any role for HUWE1 in MYC signalling? | HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation., To determine the importance of HUWE1, we chose to examine its function in colorectal cancer, where it is mutated in up to 15 per cent of tumours. Modelling of identified mutations showed that... | yes |
converted_1564 | Are adenylyl cyclases always transmembrane proteins? | ransmembrane adenylyl cyclase, Transmembrane adenylyl cyclase (tmAC) and soluble AC (sAC) , Soluble adenylyl cyclase (sAC) is a recently recognized source of the signaling molecule cyclic AMP (cAMP) that is genetically and biochemically distinct from the classic G-protein-regulated transmembrane adenylyl cyclases (tmA... | no |
converted_825 | Could Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
cause sudden cardiac death? | Two siblings died suddenly at the ages of 9 and 10 years, Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a type of cardiac arrhythmia that occurs in people with a structurally normal heart. Stress or anxiety-induced release of endogenous catecholamines causes a dysfunction in the myocytic calcium-ion c... | yes |
converted_4162 | Are somatic mutations positioned towards the nuclear periphery? | lamina-associated regions, which are typically localized at the nuclear periphery, displayed higher somatic mutation frequencies than did the interlamina regions at the nuclear core., Furthermore, mutational signatures differed between the nuclear core and periphery, thus indicating differences in the patterns of DNA-d... | yes |
converted_3500 | Does deletion of cohesin change gene expression? | The conditional deletion of cohesin from noncycling thymocytes preserved enhancer position, H3K27ac, H4K4me1, and enhancer transcription, but weakened interactions between enhancers., Interestingly, ∼ 50% of deregulated genes reside in the vicinity of enhancer elements, suggesting that cohesin regulates gene expressio... | yes |
converted_4036 | Is colistin an antibiotic? | all antibiotics tested, apart from colistin, , Among the selected antibiotics, there were 12 fluoroquinolone antibiotics (tosufloxacin, levofloxacin, sparfloxacin, clinafloxacin, pazufloxacin, gatifloxacin, enrofloxacin, lomefloxacin, norfloxacin, fleroxacin, flumequine, ciprofloxacin), 15 beta-lactam or cephalosporin ... | yes |
converted_2666 | Is sternotomy closure done using either a sternal ZipFix™ implant or conventional steel wire following cardiac surgery? | o determine the difference in sternal infection and other infectious events between conventional wire and cable-tie-based closure techniques post-sternotomy in a collective of patients after cardiac surgery., Our study underlines a neutral effect of the sternal ZipFix™ system in patients regarding sternal infection. Po... | yes |
converted_1370 | Are nucleosomes positioned at DNA replication origins? | yeast origins are characterized by an asymmetric pattern of positioned nucleosomes flanking the ACS. The origin sequences are sufficient to maintain a nucleosome-free origin; however, ORC is required for the precise positioning of nucleosomes flanking the origin., Here, we identify nucleosome occupancy as a likely cand... | no |
converted_550 | Does d-tubocurarine (d-TC) induces irreversible inhibition of nicotinic acetylcholine receptor (nAChR) at the neuromuscular junction? | An integrated model describing the interaction of nondepolarizing neuromuscular blocking agents with reversible anticholinesterase agents is derived and compared with a naive model using experimental data obtained from four anesthetized dogs. Three consecutive but separate steady-state d-tubocurarine blocks (approximat... | no |
converted_1775 | Is exon skipping correlated with exon circularization? | Exon Skipping Is Correlated with Exon Circularization, We find that circularization of exons is widespread and correlates with exon skipping, a feature that adds considerably to the regulatory complexity of the human transcriptome, Exon Skipping Is Correlated with Exon Circularization., We find that circularization of ... | yes |
converted_2565 | Does armodafinil improve fatigue of glioma patients? | CONCLUSIONS: While treatment was well-tolerated, an 8-week course of armodafinil did not improve fatigue or QOL in glioma patients undergoing RT in this pilot study. , We evaluated whether armodafinil, a wakefulness-promoting medication, improves fatigue in glioma patients undergoing RT., Armodafinil did not significan... | no |
converted_4433 | Should perampanel be used for amyotrophic lateral sclerosis? | RESULTS: Six participants were enrolled. All had adverse events, mostly behavioral. Two completed the trial and the other four withdrew due to adverse events. All participants reported resolution of these events after discontinuation of the drug. The trial was halted due to the large number of adverse events.DISCUSSION... | no |
converted_360 | Have thyronamines effects on fat tissue? | In conclusion, trace amines and thyronamines are negative inotropic agents., Their in vivo administration induces effects opposite to those induced by thyroid hormone, including lowering of body temperature. | no |
converted_2145 | Are alterations in ultraconserved elements associated with colorectal adenocarcinoma? | Genetic variants within ultraconserved elements and susceptibility to right- and left-sided colorectal adenocarcinoma, Our results strongly suggest that several genetic variants in the UCEs may contribute to CRC susceptibility, individually and jointly, and that different genetic etiology may be involved in RCRC and LC... | yes |
converted_1523 | Can siRNA affect response to afatinib treatment? | On the other hand, miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR, including both TKIs (gefitinib, erlotinib, and afatinib) and a monoclonal antibody (cetuximab), These effects were independent of the EGFR mutation status (wild type, sensitizing mutation or resistance mutation), but were... | yes |
converted_4279 | Are variants in FHF2 (also known as FGF13) associated with encephalopathy? | Missense variants in the N-terminal domain of the A isoform of FHF2/FGF13 cause an X-linked developmental and epileptic encephalopathy., Whole-exome sequencing identified hemi- and heterozygous variants in the N-terminal domain of the A isoform of FHF2 (FHF2A). The X-linked FHF2 gene (also known as FGF13) has alternati... | yes |
converted_3718 | Are there negative enhancers? | Role of a YY-1 factor-binding negative enhancer, Mutations targeted to the CArG-like motif abolished the suppressive effect of the negative enhancer and the inducibility of the promoter during myogenic differentiation, Our results suggest that the activity of the negative enhancer may determine the level of expression ... | yes |
converted_431 | Is invasion and metastasis one of the hallmarks of cancer? | The pathogenesis of MM involves the accumulation of extensive cytogenetic changes, as well as cancer-related phenotypic alterations that facilitate tumor cell survival, invasion and metastasis. This review presents current knowledge regarding the biological characteristics of this disease that are linked to the so-call... | yes |
converted_2661 | Has rituximab been considered as a treatment for chronic fatigues syndrome? (November 2017) | The use of rintatolimod and rituximab as well as counselling, behavioural and rehabilitation therapy programs may be of benefit for CFS/ME, but the evidence of their effectiveness is still limited. | yes |
converted_2903 | Should dacomitinib be used for treatment of glioblastoma patients? | Expert opinion: Despite the poor global results of Dacomitinib in recurrent GB shown in a phase II trial, some patients had a significant benefit. , Conclusions: Dacomitinib has a limited single-agent activity in recurrent GB with EGFR amplification., Expert opinion: Despite the poor global results of Dacomitinib in re... | no |
converted_108 | Are stress granules involved in the pathogenesis of Amyotrophic Lateral Sclerosis? | SGs have been linked to several pathologies including inflammatory diseases, cancer, viral infection, and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)., Like several other ALS-associated proteins, CREST is recruited to induced stress granules., Our data indica... | yes |
converted_1409 | Does Apolipoprotein E (ApoE) have anti-inflammatory activity? | have previously reported that apolipoprotein E (apoE), a protein component of very-low-density lipoproteins (VLDL) and high-density lipoproteins and a potent plasma-borne atheroprotective factor, exerts anti-inflammatory activity in macrophages by switching the activation profile from M1 ("classic") to M2 ("alternativ... | yes |
converted_2372 | Is there any linear-time and linear-space algorithm for the computation of avoided words in biological sequences? | The systematic search for avoided words is particularly useful for biological sequence analysis. We present a linear-time and linear-space algorithm for the computation of avoided words of lengthkin a given sequencex. We suggest a modification to this algorithm so that it computes all avoided words ofx, irrespective of... | yes |
converted_4203 | Does AZD3759 cross the blood brain barrier? | AZD3759, an EGFR tyrosine kinase inhibitors (TKIs) with excellent blood-brain barrier (BBB) penetration,, AZD3759, a BBB-penetrating EGFR inhibitor for the treatment of EGFR mutant NSCLC with CNS metastases, We report the discovery and early clinical development of AZD3759, a selective EGFR inhibitor that can fully pen... | yes |
converted_402 | Is paroxetine effective for treatment of premenstrual dysphoric disorder? | To evaluate the cost effectiveness of the four medications with a US FDA-approved indication for PMDD: fluoxetine, sertraline, paroxetine and drospirenone plus ethinyl estradiol (DRSP/EE)., All SSRIs (fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, and clomipramine) were effective in reducing premenstrual ... | yes |
converted_3480 | Does nintedanib hold promise for lung disease associated with systemic sclerosis? | The patient developed progressive lung fibrosis under several immunosuppressants and was started on nintedanib, with clinical and functional stabilization. Nintedanib is a tyrosine-kinase inhibitor that blocks several profibrotic pathways, inhibiting proliferation and migration of fibroblasts and decreasing the synthes... | yes |
converted_4052 | Is SLIC-CAGE used for quantification of translation? | Transcription Start Site Mapping Using Super-low Input Carrier-CAGE., SLIC-CAGE: high-resolution transcription start site mapping using nanogram-levels of total RNA., Cap analysis of gene expression (CAGE) is a methodology for genome-wide quantitative mapping of mRNA 5' ends to precisely capture transcription start sit... | no |
converted_375 | Is lambrolizumab effective for treatment of patients with melanoma ? | However, through parallel efforts that have showcased the efficacy of small-molecule BRAF and MAP-ERK kinase (MEK) inhibitors, as well as the immune checkpoint inhibitors, namely ipilimumab and the anti-PD1/PDL1 antibodies (lambrolizumab, nivolumab, MPDL3280), an opportunity exists to transform the treatment of melanom... | yes |
converted_3291 | Is traditional Chinese medicine associated with a decreased risk of heart failure in breast cancer patients receiving doxorubicin treatment? | Traditional Chinese medicine is associated with a decreased risk of heart failure in breast cancer patients receiving doxorubicin treatment, Using TCM significantly decreased the incidence of CHF in patients with breast cancer who received conventional chemotherapy with or without radiotherapy., Traditional Chinese me... | yes |
converted_3708 | Does ESN364 activate the hypothalamic-pituitary-gonadal axis? | Oral administration of the NK3R antagonist, ESN364, suppressed the hypothalamic-pituitary-gonadal axis in healthy volunteers by selective modulation of gonadotropin secretion, leading to a restrained decrease in ovarian hormone levels in women. | no |
converted_539 | Are integrins part of the extracellular matrix? | Several constituents of the ECM provide adhesive cues, which serve as binding sites for cell trans-membrane receptors, such as integrins., We also determined that blocking β1integrins, the major class of receptors for all ECM proteins tested,, Here, we elucidate a cross-scale mechanism for tissue assembly and ECM remod... | yes |
converted_2179 | Is airplane stroke syndrome a common disease. | Only 37 cases of stroke during or soon after long-haul flights have been published to our knowledge. , Our centre admitted 5727 stroke patients, of whom 42 (0.73%) had flight-related strokes., The authors report three cases of ischemic stroke in young adults that occurred during or after an airplane flight. | no |
converted_1701 | Is the protein KCNQ2 associated with idiopathic epilepsy? | Juvenile idiopathic epilepsy (JIE) in Arabian foals resembles benign-familial neonatal convulsion (BFNC) syndrome, a rare idiopathic epilepsy of new-born humans. BFNC syndrome exhibits genetic heterogeneity, as has been hypothesised to occur in Arabian foals, and is known to be caused by mutations in the voltage-gated ... | yes |
converted_2509 | Is creatinine assessment included in the MELD score? | Model For End-Stage Liver Disease (MELD) scores were calculated as 3.78×ln[TB] + 11.2×ln[INR] + 9.57×ln[creatinine] + 6.43. , A corrected creatinine was derived from the mGFR after application of the Modification of Diet in Renal Disease formula. Subsequently, a corrected MELD was calculated and compared with the conve... | yes |
converted_957 | Is selenium deficiency involved in autoimmune thyroid disease? | In areas with severe selenium deficiency higher incidence of thyroiditis has been reported due to a decreased activity of selenium-dependent glutathione peroxidase enzyme within thyroid cells, Of 30 patients in the selenium treated group, 6 patients were overtly hypothyroid, 15 were subclinical hypothyroid, 6 were euth... | yes |
converted_3073 | Is the NLM medical text indexer (MTI) still useful and relevant? | 12 years on - Is the NLM medical text indexer still useful and relevant?, Facing a growing workload and dwindling resources, the US National Library of Medicine (NLM) created the Indexing Initiative project in 1996. This cross-library team's mission is to explore indexing methodologies for ensuring quality and currency... | yes |
converted_2378 | Is a CpG island methylator phenotype involved in ependymomas? | Although devoid of recurrent single nucleotide variants and focal copy number aberrations, poor-prognosis hindbrain ependymomas exhibit a CpG island methylator phenotype, Although no recurrently mutated genes were found throughout these groups of ependymomas, PFA exhibited a CpG island methylator phenotype, PFB was ass... | yes |
converted_1644 | Is Calcium/Calmodulin dependent protein kinase II (CaMKII) involved in cardiac arrhythmias and heart failure? | In human hypertrophy, both CaMKII and PKA functionally regulate RyR2 and may induce SR Ca(2+) leak. In the transition from hypertrophy to HF, the diastolic Ca(2+) leak increases and disturbed Ca(2+) cycling occurs. This is associated with an increase in CaMKII- but not PKA-dependent RyR2 phosphorylation. CaMKII inhibit... | yes |
converted_4213 | Is capmatinib effective for glioblastoma? | CONCLUSION: The combination of INC280/buparlisib resulted in no clear activity in patients with recurrent PTEN-deficient glioblastoma. | no |
converted_3962 | Is MIS-C or Multisystem Inflammatory syndrome in children a complication of Covid-19? | Much remains unknown about the risk factors, pathogenesis, prognosis, and specific therapy for this emerging manifestation of COVID-19 known as Multisystem Inflammatory Syndrome in Children (MIS-C)., Multisystem Inflammatory Syndrome in Children During the Coronavirus 2019 Pandemic: A Case Series, COVID-19 and Multisys... | yes |
converted_712 | Is PER3 required for CHK2 activation in human cells? | Per3, a circadian gene, is required for Chk2 activation in human cells., Depletion of Per3 by siRNA almost completely abolished activation of checkpoint kinase 2 (Chk2) after inducing DNA damage in human cells., Per3 overexpression induced Chk2 activation in the absence of exogenous DNA damage,, Per3 overexpression als... | yes |
converted_2256 | Is tretinoin effective for photoaging? | Background. Tretinoin has been shown to improve photoaged skin. This study was designed to evaluate the efficacy and tolerability of a 5% retinoic acid peel combined with microdermabrasion for facial photoaging., .Conclusion. This study demonstrated that 5% retinoic acid peel cream combined with microdermabrasion was s... | yes |
converted_4038 | Is the process of DNA loop-extrusion independent of ATP? | The DNA-organizing mechanism of condensin depends on the energy of ATP hydrolysis but how this activity specifically promotes proper compaction and segregation of chromosomes during mitosis remains poorly understood., We suggest that loading and translocation are mediated by conformational changes in cohesin's hinge dr... | yes |
converted_404 | Is endostatin a proangiogenic factor? | endostatin (antiangiogenic factor, antiangiogenic factors include thrombospondin-1, angiostatin, and endostatin, human endostatin (rh-endostatin), a potential antiangiogenic agent, , antiangiogenic PF4 and endostatin, Angiostatin and endostatin are endogenous inhibitors of angiogenesis with anticancer effects, the ant... | no |
converted_904 | Are there any desmins present in plants? | Inherited mutations in the gene coding for the intermediate filament protein desmin have been demonstrated to cause severe skeletal and cardiac myopathies., Mutations in the intermediate filament (IF) protein desmin cause severe forms of myofibrillar myopathy characterized by partial aggregation of the extrasarcomeric ... | no |
converted_4355 | Is Mycobacterium abscessus a human pathogen? | Mycobacterium abscessus is unique in terms of its high morbidity and treatment failure rates, Mycobacterium abscessus has emerged as a successful pathogen owing to its intrinsic drug resistance. , Mycobacterium abscessus lung disease is difficult to treat due to intrinsic drug resistance and the persistence of drug-tol... | yes |
converted_4611 | Has CPX-351 been approved by the FDA and the EMA? | CPX-351 (United States: Vyxeos®; Europe: Vyxeos® Liposomal), a dual-drug liposomal encapsulation of daunorubicin and cytarabine in a synergistic 1:5 molar ratio, is approved by the US FDA and the EMA for the treatment of adults with newly diagnosed therapy-related acute myeloid leukemia or acute myeloid leukemia with m... | yes |
converted_2231 | Is apremilast effective for psoriatic arthritis? | Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis and current skin involvement: a phase III, randomised, controlled trial (PALACE 3)., OBJECTIVE: To evaluate apremilast treatment in patients with active psoriatic arthritis, including current skin involvement, despite prior therapy ... | yes |
converted_72 | Are transcribed ultraconserved regions involved in cancer? | Although most cancer research has focused in mRNA, non-coding RNAs are also an essential player in tumorigenesis. In addition to the well-recognized microRNAs, recent studies have also shown that epigenetic silencing by CpG island hypermethylation of other classes of non-coding RNAs, such as transcribed ultraconserved ... | yes |
converted_1501 | Have germline variants been associated to colorectal cancer? | Overall, we identified aberrant transcripts in 8% of the patients (familial cases 30%; early-onset manifestation 21%). In eight of them, two different out-of-frame pseudoexons were found consisting of a 167-bp insertion from intron 4 in five families with a shared founder haplotype and a 83-bp insertion from intron 10 ... | yes |
converted_3710 | Has ORMD-0801 been tested in patients? | Glucose-reducing effect of the ORMD-0801 oral insulin preparation in patients with uncontrolled type 1 diabetes: a pilot study., In efforts to provide patients with a more compliable treatment method, Oramed Pharmaceuticals tested the capacity of its oral insulin capsule (ORMD-0801, 8 mg insulin) in addressing this res... | yes |
converted_1594 | Is Tuberous Sclerosis a genetic disease? | Tuberous sclerosis complex (TSC) is a genetic disease, Tuberous sclerosis is a rare genetic disease, Tuberous sclerosis complex (TSC) is a multisystem genetic disease, Tuberous sclerosis complex (TSC) is a genetic disease, The disease is caused by mutational inactivation of the tumor suppressor gene tuberous sclerosis ... | yes |
converted_818 | Is there evidence to suggest that triiodothyronine has neuroprotective properties in traumatic brain injury? | Exogenous T3 administration provides neuroprotection in a murine model of traumatic brain injury., Treatment with T3 (1.2μg/100g body weight, i.p.) 1h after TBI resulted in a significant improvement in motor and cognitive recovery after CCI, as well as in marked reduction of lesion volumes. , Western blot analysis reve... | yes |
converted_2834 | Is obesity related to cognitive decline? | The initial results suggests that obese children have higher cognitive scores and that this result is driven by those who are female, non-indigenous and live in an urban region., On the other end of the weight distribution, indigenous children who are severely thin or thin have significantly lower cognitive scores, a r... | yes |
converted_3243 | Does GRHL2 over-expression lead to EMT? | Grhl2 is down-regulated in disseminated cancer cells that have undergone EMT, and over-expression of Grhl2 is sufficient to induce epithelial gene expression., Grhl2 plays an essential role in the determination of epithelial phenotype of breast cancers, EMT and tumor progression., In breast cancer cell lines, shRNA-me... | no |
converted_3880 | Does inactivation of CYLD help in colorectal cancer? | Inactivation of CYLD in intestinal epithelial cells exacerbates colitis-associated colorectal carcinogenesis - a short report., CYLD is a tumor suppressor that has been linked to the development of various human malignancies, including colon cancer. The tumor-suppressing function of CYLD is associated with its deubiqui... | no |
converted_296 | is intense physical activity associated with longevity ? | We found a very significant increase in average longevity (17%) of the cyclists when compared with the general population. The age at which 50% of the general population died was 73.5 vs. 81.5 years in Tour de France participants. Our major finding is that repeated very intense exercise prolongs life span in well train... | yes |
converted_288 | Can zinc finger nucleases be used to combat disease? | Genetic engineering has emerged as a powerful mechanism for understanding biological systems and a potential approach for redressing congenital disease., This is of particular importance, given the momentum currently behind ZFNs in moving into phase I clinical trials. This study provides a historical account of the ori... | yes |
converted_1880 | Are alterations in ultraconserved elements implicated in breast cancer? | SNPs in ultraconserved elements and familial breast cancer risk, In the present study, we investigated the influence of six SNPs within UCEs on familial breast cancer risk. Two out of six SNPs showed an association with familial breast cancer risk, This is the first study indicating that SNPs in UCEs might be associat... | yes |
converted_3536 | Is there an increased risk of meningiomas in atomic bomb survivors? | RESULTS: Meningioma was the most common tumor among clinically diagnosed tumors, followed by neuroepithelial tumor, schwannoma, and pituitary tumor. , The predominance of meningiomas over neuroepithelial tumors in the Japanese population was noteworthy and warrants further investigation. , Risk increases, although not ... | yes |
converted_905 | Are viruses involved in the etiology of human subacute thyroiditis? | he etiology of subacute (de Quervain's) thyroiditis (SAT) is uncertain, although it probably represents a nonspecific inflammatory response by the thyroid to a variety of viruses., Subacute thyroiditis is an inflammatory disorder of the thyroid caused probably by viruses. I, We believe that the etiologic agent was the ... | yes |
converted_2327 | Is ACI-35 a passive vaccine? | Two active vaccines targeting either nonphosphorylated (AAD-vac1) and phosphorylated tau (ACI-35) have entered Phase I testing. | no |
converted_646 | Are chromomethylases present in animal genomes? | Many plant, animal, and fungal genomes contain cytosine DNA methylation in asymmetric sequence contexts (CpHpH, H = A, T, C)., However, at the SUPERMAN locus, asymmetric methylation was only completely abolished in drm1 drm2 chromomethylase 3 (cmt3) triple mutant plants., Although neither the drm1 drm2 double mutants n... | no |
converted_1108 | Is PLK2 involved in alpha-synuclein phosphorylation in Parkinson disease? | An increase in α-synuclein levels due to gene duplications/triplications or impaired degradation is sufficient to trigger its aggregation and cause familial Parkinson disease , Here, we report that Polo-like kinase 2 (PLK2), an enzyme up-regulated in synucleinopathy-diseased brains, interacts with, phosphorylates and e... | yes |
converted_4497 | Should istiratumab be used for Pancreatic Cancer? | CONCLUSIONS: Istiratumab failed to improve the efficacy of SOC chemotherapy in this patient setting. , In the high IGF-1 cohort, median PFS was 3.6 and 7.3 months in the experimental versus control arms, respectively [hazard ratio (HR) = 1.88, P = 0.027]. In the high IGF-1/HRG+ subgroup (n = 44), median PFS was 4.1 and... | no |
converted_4250 | Is Ozanimod effective for Ulcerative Colitis? | Ozanimod as Induction and Maintenance Therapy for Ulcerative Colitis., CONCLUSIONS: Ozanimod was more effective than placebo as induction and maintenance therapy in patients with moderately to severely active ulcerative colitis., CONCLUSIONS: There was a high rate of continued study participation and long-term benefit ... | yes |
converted_3849 | Can ATAC-Seq be employed in single-cell mode? | Single-cell ATAC-seq: strength in numbers., Assembly, and Single-Cell ATAC-Seq., Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement., Here, we comprehensively characterize mouse cardiac progenitor cells (CPCs) marked by Nkx2-5 and Isl1 expression from E7.5 to ... | yes |
converted_2663 | Is the petrous bone used in ancient DNA sampling? | Large-scale genomic analyses of ancient human populations have become feasible partly due to refined sampling methods. The inner part of petrous bones and the cementum layer in teeth roots are currently recognized as the best substrates for such research., Ancient DNA (aDNA) research involves invasive and destructive s... | yes |
converted_3030 | Is avelumab effective for bladder cancer? | BACKGROUND: Avelumab has recently been approved by the Food and Drug Administration for the therapy of Merkel cell carcinoma and urothelial carcinoma., Six drugs including one CTLA-4 blocker (ipilimumab), two PD-1 blockers (nivolumab and pembrolizumab) and three PD-L1 blockers (atezolizumab, avelumab and durvalumab) ar... | yes |
converted_1467 | Are BRAF mutations common in melanoma? | patients with BRAF-mutant melanoma., BRAF-mutated melanoma , The RAS/RAF/MEK/ERK pathway has been reported to be activated in over 80% of all cutaneous melanomas, making it the focus of many scientific studies in the melanoma field. Discoveries of mutations and aberrant expression of components in this cascade, in part... | yes |
converted_2588 | Are osteoclasts specialized in bone degradation? | osteoclast-mediated attack on bone, Bone degradation is caused by osteoclasts, the normal bone-resorbing cells. , Cathepsin K is a highly potent collagenase in osteoclasts and is responsible for bone degradation., In osteoclasts, Src controls podosome organization and bone degradation, which leads to an osteopetrotic p... | yes |
converted_524 | Is the protein β1-integrin recycled? | Pathways selectively regulating β1-integrin recycling are implicated in cancer invasion and metastasis,, integrin-positive early and recycling endosomes , LPA-induced recycling of β1 integrin,, RCP-mediated recycling of α5β1 integrin , CycD1 overexpression increased β1 integrin recycling , inhibition of autophagy slowe... | yes |
converted_4514 | Do angiotensin-converting-enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) increase the likelihood of severe COVID-19? | These findings suggest that the use of ACE-I and ARB is not associated with adverse outcomes and may be associated with improved outcomes in COVID-19, which is immediately relevant to care of the many patients on these medications., There are theoretical concerns that angiotensin-converting enzyme inhibitors (ACEIs) an... | no |
converted_63 | Are long non coding RNAs as conserved in sequence as protein coding genes? | Most lncRNAs are under lower sequence constraints than protein-coding genes and lack conserved secondary structures, making it hard to predict them computationally., hey are under stronger selective pressure than neutrally evolving sequences-particularly in their promoter regions, which display levels of selection comp... | no |
converted_3996 | Are mucin overexpression associated with disease? | The pathological mechanism underlying hepatolithiasis is closely related to bacterial infections of the intrahepatic bile duct, followed by chronic inflammation and the overexpression of mucin 5AC (MUC5AC)., MUC1 is a membrane glycoprotein, which in adenocarninomas is overexpressed and exhibits truncated O-glycosylatio... | yes |
converted_897 | Does magnesium sulfate improve outcomes of subarachnoid hemorrhage patients? | CONCLUSION: Patients assigned a higher serum magnesium concentration had a reduced incidence of vasospasm as seen by angiography, but the difference was not statistically significant. Clinically significant outcomes were not different between groups., 158 patients (26·2%) had poor outcome in the magnesium group compare... | no |
converted_24 | Is Alu hypomethylation associated with breast cancer? | Alu and LINE-1 hypomethylation is associated with HER2 enriched subtype of breast cancer, In IBC, Alu hypomethylation correlated with negative estrogen receptor (ER) status, In survival analyses, low Alu methylation status tended to be associated with poor disease-free survival of the patients., Alu hypomethylation is ... | yes |
converted_2364 | Are Conserved Nonexonic Elements (CNEEs) important in phylogenomics research? | Overall, CNEEs appear to be promising as phylogenomic markers, yielding phylogenetic resolution as high as for UCEs and introns but with fewer gaps, less ambiguity in alignments and with patterns of nucleotide substitution more consistent with the assumptions of commonly used methods of phylogenetic analysis., Conserve... | yes |
converted_4243 | Is RUNX1T1 associate with obesity? | RUNX1T1 rs34269950 is associated with obesity and metabolic syndrome., Of these SNPs only rs34269950 located in the 'RRACH' motif, the most common N6-methyladenosine (m6A) methylation modification site (recognized by FTO), was significantly associated with obesity risk and metabolic abnormalities. Specifically, compare... | yes |
converted_3294 | Is PTEN a tumour suppressor? | PTEN is a potent tumour suppressor, Genomic aberrations of the PTEN tumour suppressor gene are among the most common in prostate cancer. | yes |
converted_3375 | Are breaks in double stranded DNA associated with ionizing radiation? | DNA double-strand breaks (DSBs) are major DNA lesions that are constantly formed during physiological processes such as DNA replication, transcription, and recombination, or as a result of exogenous agents such as ionizing radiation, radiomimetic drugs, and genome editing nucleases, Whereas most endogenous and exogenou... | yes |
converted_1985 | Does HuR bind to the untranslated regions (UTRs) of mRNAs? | HuR is also overexpressed during tumourigenesis and is abnormally present within the cytoplasm, where it binds to AU-rich elements in the 3'UTRs of target mRNA and post-transcriptionally regulates the expression of its target genes., Human antigen R (HuR) is a ubiquitous 32 kDa protein comprising three RNA Recognition ... | yes |
converted_2973 | Have yeast prions become important models for the study of the basic mechanisms underlying human amyloid diseases? | Endogenous yeast amyloids that control heritable traits and are frequently used as models for human amyloid diseases are termed yeast prions, Fibrous cross-β aggregates (amyloids) and their transmissible forms (prions) cause diseases in mammals (including humans) and control heritable traits in yeast. , These infectiou... | yes |
converted_4428 | Is there a dependence between chromatin organization and dorsoventral gene expression in Drosophila? | Independence of chromatin conformation and gene regulation during Drosophila dorsoventral patterning., Here, using the dorsoventral patterning of the Drosophila melanogaster embryo as a model system, we provide evidence for the independence of chromatin organization and dorsoventral gene expression. We define tissue-sp... | no |
converted_2933 | Is there a deep-learning algorithm for protein solubility prediction? | DeepSol: a deep learning framework for sequence-based protein solubility prediction., Protein solubility plays a vital role in pharmaceutical research and production yield. For a given protein, the extent of its solubility can represent the quality of its function, and is ultimately defined by its sequence. Thus, it is... | yes |
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