id stringlengths 11 14 | sentence1 stringlengths 20 192 | sentence2 stringlengths 50 19.2k | label stringclasses 2
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converted_4190 | Do honey contain diastases/amylases? | A new rapid method for the determination of honey diastase activity using direct potentiometric principles has been proposed. , The major alpha-amylase in honey was characterized. , Separation of honey amylase | yes |
converted_218 | Has vitamin D has been shown to reduce incidence of falls in older people in clinical trials? | However, apart from the beneficial effects of 800 IU/d of vitamin D3 for reduction of falls in the elderly, causality remains yet unproven in randomized controlled trials (RCTs). , The rate of falls and the number of fallers was significantly reduced in two studies evaluating the effect of medication on preventing fall... | yes |
converted_1513 | Is thrombophilia related to increased risk of miscarriage? | Thrombophilia does hardly increase the risk of IUGR/PMPC or if so, it can be prevented by LMWH, for illustrative purposes, a patient presenting with combined thrombophilia--both genetic and acquired--will be discussed. This patient had suffered severe gestational complications that led to devastating obstetrical outcom... | yes |
converted_49 | Are ultraconserved elements often transcribed? | Starting from a genome-wide expression profiling, we demonstrate for the first time a functional link between oxygen deprivation and the modulation of long noncoding transcripts from ultraconserved regions, termed transcribed-ultraconserved regions (T-UCRs), Our data gives a first glimpse of a novel functional hypoxic ... | yes |
converted_983 | Have mutations in the ZEB2 gene been found in any human syndrome? | Mowat-Wilson syndrome is a genetic disease caused by heterozygous mutations or deletions of the zinc finger E-box-binding homeobox 2 (ZEB2) gene, Mowat-Wilson syndrome (MWS; OMIM#235730) have characteristic facial features, a variety of congenital anomalies such as Hirschsprung disease, and intellectual disabilities ca... | yes |
converted_1325 | Do all archaea possess multiple origins of DNA replication? | Origins differ in number and structure across the three domains of life and their properties determine the dynamics of chromosome replication. Bacteria and some archaea replicate from single origins, whereas most archaea and all eukaryotes replicate using multiple origins., Replication starts at a single Ori site in ba... | no |
converted_1394 | Are shadow enhancers associated with development? | Critical developmental control genes sometimes contain "shadow" enhancers that can be located in remote positions, including the introns of neighboring genes, These results suggest that shadow enhancers represent a novel mechanism of canalization whereby complex developmental processes "bring about one definite end-res... | yes |
converted_2315 | Is propranolol used for treatment of infantile hemangioma? | Low-dose propranolol for infantile hemangioma of the head and neck: Analysis of 23 consecutive patients., BACKGROUND: More and more infantile hemangiomas (IH) are being treated with propranolol, but the effectiveness, dosage, and treatment course are still in dispute., CONCLUSIONS: Low-dose propranolol appears to be ef... | yes |
converted_837 | Are defects in recombination repair involved in carcinogenesis? | Inherited mutations in genes involved in HR are associated with gene rearrangement and may be a prerequisite for tumor development in some cancer-prone hereditary diseases like Bloom, Werner and Rothmund-Thomson syndromes. , Variants in the XRCC3 gene might result in altered protein structure or function which may infl... | yes |
converted_4566 | Is Otolin-1 a matrix protein? | otoconia matrix protein, otolin-1, Otolin-1 is a collagen-like protein expressed in the inner ear of vertebrates. , Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1, binds to otolin-1 and forming matrix protein architectures | yes |
converted_79 | Are there any urine biomarkers for chronic kidney disease? | Kidney and urine proteomic biomarkers are considered as promising diagnostic tools to predict CKD progression early in diabetic nephropathy, facilitating timely and selective intervention that may reduce the related health-care expenditures., Both blood and urine biomarkers are reviewed in this paper and offer a consid... | yes |
converted_1563 | Are cyclophilins ubiquitously expressed? | Cyclophilin from Leishmania donovani (LdCyp) is a ubiquitous peptidyl-prolyl cis-trans isomerase, Cyclophilins (CYPs) and FK506-binding proteins (FKBPs) are ubiquitous proteins belonging to the peptidyl-prolyl cis/trans isomerase (PPIase) family., However, their wide distribution and ubiquitous nature signifies their ... | yes |
converted_4418 | Do SETD1A mutations predispose to schizophrenia? | Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice., SETD1A, a lysine-methyltransferase, is a key schizophrenia susceptibility gene. Mice carrying a heterozygous loss-of-function mutation of the orthologous gene exhibit alterations in axonal branching and cortical synaptic dynamics... | yes |
converted_3349 | The LINCS L1000 data set contains gene expression data for drug treated human cells, yes or no? | Library of Integrated Network-based Cellular Signatures (LINCS) L1000 dataset that measured changes in GE before and after treatment of human cells with over 20 000 small-molecule compounds including most of the FDA-approved drugs., The Library of Integrated Network-based Cellular Signatures (LINCS) L1000 big data pro... | yes |
converted_3263 | Are astrocytes part of the blood brain barrier? | The blood-brain barrier (BBB) is a tight boundary formed between endothelial cells and astrocytes, which separates and protects brain from most pathogens as well as neural toxins in circulation., The blood-brain barrier (BBB) consists of endothelial cells, astrocytes, and pericytes embedded in basal lamina (BL). | yes |
converted_1486 | Does ventriculoperitoneal shunt improve normal pressure hydrocephalus? | Clinical improvement depends not only on the capability to restore the cerebrospinal fluid dynamic, but also on the ability of cerebral parenchyma to recover the metabolic function., After shunting, the global CMRglu significantly increased (2.95 ± 0.44 vs 4.38 ± 0.68, p = 10(-7)) in all INPH patients with a mean perc... | yes |
converted_4357 | Is MEDI2228 a bispecific antibody? | We here delineated the molecular and cellular mechanisms underlying novel immunomodulatory effects triggered by BCMA pyrrolobenzodiazepine (PBD) antibody drug conjugate (ADC) MEDI2228 which can augment efficacy of these immunotherapies. | no |
converted_820 | Is Lysine-specific demethylase 1 (LSD1) a critical regulator of hematopoiesis? | Histone lysine-specific demethylase 1 (LSD1) protein is involved in Sal-like protein 4 (SALL4)-mediated transcriptional repression in hematopoietic stem cells, shRNA-mediated knockdown of LSD1 in hematopoietic precursor cells resulted in altered SALL4 downstream gene expression and increased cellular activity, our data... | yes |
converted_773 | Is corpus callosum involved in the Mowat–Wilson syndrome? | The syndrome is characterized by typical facial features, moderate-to-severe mental retardation, epilepsy and variable congenital malformations, including Hirschsprung disease, genital anomalies, congenital heart disease, agenesis of the corpus callosum, and eye defects. , Mowat-Wilson syndrome in a fetus with antenat... | yes |
converted_2454 | Does the human lncRNA LINC-PINT promote tumorigenesis? | The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element., Here we characterize the function of the p53-regulated human lncRNA LINC-PINT in cancer. We find that LINC-PINT is downregulated in multiple types of cancer and acts as a tumor suppressor lncRNA by reducing the invasiv... | no |
converted_1612 | Is physical performance influenced by thyroid hormone metabolism? | Longitudinal analysis showed that in Eut men higher baseline FT4 was significantly (p = 0.02) predictive of a lower SPPB score at the 3-year follow-up, Even a modest thyroid hormone excess is associated with a reduced physical function in elderly men., Oral L-thyroxine treatment was started and at a 1-month follow-up e... | yes |
converted_2347 | Do bacteria from the genus Morexella cause respiratory infections? | gainst pathogens associated with respiratory tract ailments [Staphylococcus aureus (ATCC 25923), Klebsiella pneumoniae (ATCC 13883) and Morexella cattarhalis (ATCC 14468)] , The efficacy and safety of oral ofloxacin, 400 mg once daily, for the treatment of patients with lower respiratory tract infections were studied. ... | yes |
converted_1671 | Is LPS a microbial product? | and microbial translocation [lipopolysaccaride (LPS), microbial 16S rDNA and sCD14] , Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections, bacterial lipopolysaccharide (LPS), sterile bacterial wall lipopolysaccharide (LPS) to investigate the changes in inna... | yes |
converted_711 | Do proton pump inhibitors affect thyroxine absorption? | Proton-pump inhibitors, antacids and a long list of drugs may decrease thyroxine absorption, Many commonly used drugs, such as bile acid sequestrants, ferrous sulphate, sucralfate, calcium carbonate, aluminium-containing antacids, phosphate binders, raloxifene and proton-pump inhibitors, have also been shown to interfe... | yes |
converted_3362 | Is CTCF bound at nucleosome free regions? | Nucleosome depletion at 5'-HS4 was dependent on interaction of the insulator protein CCCTC-binding factor (CTCF) and was required for enhancer blocking. , Here, we show that promoter classes are significantly differentiated by nucleosome organization and chromatin structure. Dispersed promoters display higher associati... | yes |
converted_682 | Is sumoylation implicated in myogenesis? | Sentrin/small ubiquitin-like modifier (SUMO)-specific protease 2 (SENP2) has broad de-SUMOylation activities in vitro, which is essential for embryonic heart development., Silencing SENP2 can reduce myostatin expression and, therefore, promote myogenesis of skeletal muscle. These results reveal the important role of SE... | yes |
converted_2662 | Does oncogene-induced DNA replication stress inhibit genomic instability? | Oncogene-induced DNA replication stress is thought to drive genomic instability in cancer., We propose that single-stranded DNA generated in response to oncogene-induced replication stress compromises the repair of deaminated cytosines and other damaged bases, leading to the observed SNS mutator phenotype. | no |
converted_2492 | Are patients with Sjogren syndrome at increased risk for lymphoma? | The heightened risk of non-Hodgkin lymphoma (NHL) development in primary Sjogren syndrome (SS) is well established., Primary Diffuse Large B-Cell Lymphoma of the Liver in a Patient with Sjogren Syndrome., Immunohistochemical and molecular features of the tumors allowed diagnosis of diffuse large B-cell lymphoma (DLBCL)... | yes |
converted_3791 | Do nematodes contain a CTCF gene? | Our findings show that CTCF and possibly chromatin insulation are present in basal nematodes. We suggest that the insulator protein CTCF has been secondarily lost in derived nematodes like C. elegans., The most highly enriched motif (LM1) corresponds to the X-box motif known from yeast and nematode. , show that three ... | yes |
converted_2549 | Are stress granules membraneous? | PMLOs are different in size, shape, and composition, and almost invariantly contain intrinsically disordered proteins (e.g., eIF4B and TDP43 in stress granules,, Liquid-liquid phase separation (LLPS) of RNA-binding proteins plays an important role in the formation of multiple membrane-less organelles involved in RNA me... | no |
converted_1658 | Does cucumber lower blood sugar in diabetics? | The ethanolic extract of Cucumis sativus Linn, Cucumis melo utilissimum Roxb, Cucumis melo Linn, Benincasa hispida Thunb Cogn and Tricosanthes anguina Nees, when administered in 250 mg/kg dose, orally to rats failed to lower blood sugar or to depress the peak value, after glucose load., Ethanolic extract of Tricosanthe... | yes |
converted_2408 | Was saracatinib being considered as a treatment for Alzheimer's disease in November 2017? | A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease., Herein, we present a Phase Ib trial of the repurposed investigational drug AZD0530, a Src family kinase inhibitor specific for Fyn and Src kinase, for the treat... | yes |
converted_4512 | Does p85α homodimerize? | homodimerized p85α, p110α-free p85α homodimerizes, homodimeric but not monomeric p85α | yes |
converted_4677 | Is Ameloblastoma (AB) a benign tumor that never metastasizes? | Ameloblastic carcinoma (AC) is defined as a rare primary epithelial odontogenic malignant neoplasm and the malignant counterpart of benign epithelial odontogenic tumor of ameloblastoma (AB) by the WHO classification, AC develops pulmonary metastasis in about one third of the patients and reveals a poor prognosis, Amelo... | no |
converted_2667 | Is transcription of eRNA bidirectional? | In addition to widespread transcription of long non-coding RNAs (lncRNAs) in mammalian cells, bidirectional ncRNAs are transcribed on enhancers, and are thus referred to as enhancer RNAs (eRNAs)., Kallikrein-related peptidase 3 (KLK3), which codes for prostate-specific antigen (PSA), is a well-known AR-regulated gene a... | yes |
converted_1871 | Can NEECHAM Confusion Scale be used for evaluation of postoperative delirium? | Sampling was achieved in a nonrandomized targeted manner and delirium was assessed using NeeCham questionnaire. , Delirium in older patients: a diagnostic study of NEECHAM Confusion Scale in surgical intensive care unit., AIMS AND OBJECTIVES: To estimate the diagnostic value and determine the feasibility of the NEECHAM... | yes |
converted_319 | Is microRNA(miRNA) 29 involved in post-ischemic cardiac remodeling? | Myocardial ischaemia/reperfusion (I/R)-induced remodelling generally includes cell death (necrosis and apoptosis), myocyte hypertrophy, angiogenesis, cardiac fibrosis, and myocardial dysfunction. I, In addition, miR-21, -24, -133, -210, -494, and -499 appear to protect myocytes against I/R-induced apoptosis, whereas mi... | yes |
converted_3211 | Can antisense threapy be used for Huntington's disease? | In this issue of Neuron, Kordasiewicz et al. (2012) show the benefit of transient antisense oligonucleotide (ASO) therapy to degrade Huntingtin mRNA and elicit sustained therapeutic benefit in HD mice., "Huntingtin holiday": progress toward an antisense therapy for Huntington's disease. | yes |
converted_732 | Is autism one of the characteristics of Moebius syndrome? | The diagnosis of Moebius syndrome, a rare congenital disorder, is primarily based on congenital facial and abducent nerve palsy. Involvement of other cranial nerves is also common. Occasionally the V, X, XI, and XII cranial nerves are involved, resulting in a difficulty to chew, swallow, and cough, which often leads to... | yes |
converted_4 | Is RANKL secreted from the cells? | Osteoprotegerin (OPG) is a soluble secreted factor that acts as a decoy receptor for receptor activator of NF-κB ligand (RANKL) , Osteoprotegerin (OPG) is a secreted glycoprotein and a member of the tumor necrosis factor receptor superfamily. It usually functions in bone remodeling, by inhibiting osteoclastogenesis thr... | yes |
converted_3129 | Has Hesperidin any role as a Neuroprotective Agent? | Neuroprotective effect of hesperetin and nano-hesperetin on recognition memory impairment and the elevated oxygen stress in rat model of Alzheimer's disease, Hesperidin attenuates depression-related symptoms in mice with mild traumatic brain injury, Neuroprotective Effects of Hesperidin on Cerebral Vasospasm, The neuro... | yes |
converted_1706 | Can RNAPolII function as an RNA-dependent RNA-polymerase? | RNA polymerase II acts as an RNA-dependent RNA polymerase to extend and destabilize a non-coding RNA, RNA polymerase II (Pol II) is a well-characterized DNA-dependent RNA polymerase, which has also been reported to have RNA-dependent RNA polymerase (RdRP) activity., . Our studies provide compelling evidence that mammal... | yes |
converted_4178 | Do bacteria release extracellular vesicles? | Bacterial extracellular vesicles (EVs) are bilayered lipid membrane structures, bearing integral proteins and able to carry diverse cargo outside the cell to distant sites., Knowledge of the structure, molecular cargo and function of bacterial extracellular vesicles (BEVs) is primarily obtained from bacteria cultured i... | yes |
converted_1131 | Do conserved noncoding elements co-occur with matrix-attachment regions? | We hypothesized that some of these regions might be matrix-scaffold attachment regions, MARs (or S/MARs). MARs comprise one of the few classes of eukaryotic noncoding DNA with an experimentally characterized function, being involved in the attachment of chromatin to the nuclear matrix, chromatin remodeling and transcri... | yes |
converted_4655 | Is Erythropoietin effective for neuroprotection of Preterm Infants. | BACKGROUND: High-dose erythropoietin has been shown to have a neuroprotective effect in preclinical models of neonatal brain injury, and phase 2 trials have suggested possible efficacy; however, the benefits and safety of this therapy in extremely preterm infants have not been established., There was no significant dif... | no |
converted_1856 | Can beans induce apoptosis? | A 60-kDa glucosamine binding lectin, white kidney bean lectin (WKBL), was purified from Phaseolus vulgaris cv. white kidney beans, by application of anion exchange chromatography on Q-Sepharose, affinity chromatography on Affi-gel blue gel, and FPLC-size exclusion on Superdex 75. The anti-proliferative activity of WKBL... | yes |
converted_1478 | Is Titin the largest single protein molecule found in Nature? | Titin, the largest protein in the human body, is well known as a molecular spring in muscle cells and scaffold protein aiding myofibrillar assembly., Titin is the largest protein in mammals; it forms an elastic filament along the myofibril of cardiac and skeletal muscles., Titin is recently known as the largest protein... | yes |
converted_1414 | Are genes symmetrically distributed between leading and lagging DNA strand in bacteria? | Genomic DNA is used as the template for both replication and transcription, whose machineries may collide and result in mutagenesis, among other damages. Because head-on collisions are more deleterious than codirectional collisions, genes should be preferentially encoded on the leading strand to avoid head-on collision... | no |
converted_3489 | Can radiation induced meningiomas be treated with radiosurgery? | This is a case report of a patient treated with radiosurgery for radiation induced meningiomas, 30 years after childhood whole brain radiation. , This article reviews the unique characteristics and unusual response to the radiation induced meningiomas to radiosurgery. , Gamma knife stereotactic radiosurgery for radiati... | yes |
converted_3707 | Has MLE4901 been tested in phase III clinical trials? | METHODS
This phase 2, randomised, double-blind, placebo-controlled, single-centre, crossover trial assessed the effectiveness of an oral neurokinin 3 receptor antagonist (MLE4901) on menopausal hot flushes., Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double... | no |
converted_3670 | Is there a role for TET proteins in invariant natural killer T cells (iNKT) cell fate? | TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells., We found that simultaneous deletion of Tet2 and Tet3 in mouse CD4+CD8+ double-positive thymocytes resulted in dysregulated development and proliferation of invariant natural killer T cells (iNKT cells). Tet2-Tet3 double-knockout ... | yes |
converted_3042 | Is Semagacestat effective for treatment of Alzheimer's disease? | However, a large phase 3 trial of semagacestat, a potential non-transition state analog (non-TSA) GSI, in patients with Alzheimer's disease (AD) was terminated due to unexpected aggravation of cognitive deficits and side effects., BACKGROUND: In a recent report, 76 weeks' treatment with a gamma-secretase inhibitor (sem... | no |
converted_4125 | Is vocimagene amiretrorepvec effective for glioblastoma? | CONCLUSIONS: These results support an immune-related mechanism of action for Toca 511 and Toca FC, and suggest that molecular and immunologic signatures are related to clinical benefit from treatment., The median OS was 11.10 months for the Toca 511/FC group and 12.22 months for the control group (hazard ratio, 1.06; 9... | no |
converted_3649 | Is SATB1 expressed in thymocytes? | A thymocyte factor SATB1 suppresses transcription of stably integrated matrix-attachment region-linked reporter genes., SATB1 is a homeodomain protein and is predominantly expressed in thymocytes. , SATB1 is a cell-type specific nuclear protein that recruits chromatin-remodeling factors and regulates numerous genes dur... | yes |
converted_146 | Is SLC22A3 expressed in the brain? | The organic cation transporter (OCT) 3 is widely expressed in various organs in humans, and involved in the disposition of many exogenous and endogenous compounds. Several lines of evidence have suggested that OCT3 expressed in the brain plays an important role in the regulation of neurotransmission. , The organic cati... | yes |
converted_2734 | Is p53 a transcription factor? | As a transcription factor, p53 mainly exerts its tumor suppressive function through transcriptional regulation of many target genes., p53 functions primarily as a sequence-specific transcription factor that controls the expression of hundreds of protein-coding genes and noncoding RNAs, including microRNAs (miRNAs) and ... | yes |
converted_428 | Have gnotobiotic animal models been used for the study of bowel disease? | Host gene expression in the colon of gnotobiotic interleukin-2-deficient mice colonized with commensal colitogenic or noncolitogenic bacterial strains: common patterns and bacteria strain specific signatures., Specific pathogen-free (SPF), but not germfree (GF), interleukin (IL)-2-deficient (IL-2-/-) mice develop infl... | yes |
converted_3468 | Can Patient-derived organoids (PDOs) recapitulate patient responses in the clinic? | Patient-derived organoids (PDOs) have recently emerged as robust preclinical models; however, their potential to predict clinical outcomes in patients has remained unclear. We report on a living biobank of PDOs from metastatic, heavily pretreated colorectal and gastroesophageal cancer patients recruited in phase 1/2 cl... | yes |
converted_2755 | Is Baloxavir effective for influenza? | Baloxavir marboxil (Xofluza™; baloxavir) is an oral cap-dependent endonuclease inhibitor that has been developed by Roche and Shionogi. The drug blocks influenza virus proliferation by inhibiting the initiation of mRNA synthesis. In February 2018, baloxavir received its first global approval in Japan for the treatment ... | yes |
converted_4098 | Is Nanog repressed in pluripotent stem cells? | Aggregation of embryonic stem cells induces Nanog repression and primitive endoderm differentiation, Interestingly, cell aggregation by itself induced Nanog repression at the outer layer, which was essential for aggregation-induced primitive endoderm formation, early embryonic development, when downregulation of Nanog ... | no |
converted_2410 | Is overproduction of transthyretin is associated with amyloidosis associated neuropathy? | Transthyretin-associated familial amyloid polyneuropathy (TTR-FAP) is a disease caused by the deposit of abnormal transthyretin on tissues, mainly nerves, transthyretin familial amyloid polyneuropathy, We report a new transthyretin (ATTR) gene c.272C>G mutation and variant protein, p.Leu32Val, in a kindred of Bolivian ... | yes |
converted_703 | Is there an association between FGFR3 mutation and plagiocephaly? | Series of neurosurgical interventions were carried out, principally for acrocephaly and posterior plagiocephaly. The most common achondroplasia mutation, a p.Gly380Arg in the fibroblast growth factor receptor 3 (FGFR3) gene, was detected. , The most common mutation for achondroplasia (FGFR3 Gly380Arg, resulting in 113... | yes |
converted_2620 | Is DNA polymerase θ involved in DNA repair? | DNA polymerase θ (Pol θ) is implicated in various cellular processes including double-strand break repair and apurinic/apyrimidinic site bypass., Pol θ is the defining enzyme for a pathway of DSB repair termed "alternative end-joining" (altEJ) or "theta-mediated end-joining.", DNA polymerase θ is a key player in PARP-... | yes |
converted_552 | Is zyxin a focal adhesion protein? | zyxin from FAs, zyxin relocation from focal adhesions , . Here we systematically examined the expression, localization, and function of zyxin, a focal adhesion protein, focal adhesion protein zyxin, Focal adhesions formed in the absence of α-actinins are delayed in their maturation, exhibit altered morphology, have de... | yes |
converted_1656 | Is the microRNA 132 (miR-132) involved in brain pathologies? | miR-132 dysregulation and subsequent abnormal expression of miR-132 target genes contribute to the neurodevelopmental and neuromorphological pathologies present in schizophrenia., micro-RNAs encoding miR-9, miR-124a, miR-125b, miR-128, miR-132 and miR-219 are abundantly represented in fetal hippocampus, are differentia... | yes |
converted_856 | Is Dicer part of the RISC loading complex? | Dicer is a component of the protein machinery (the RNA Induced Silencing Complex [RISC]) which is involved in catalyzing the formation of mature microRNAs from their precursors in the process of microRNA biogenesis., RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor co... | yes |
converted_508 | Does cortical spreading depression appear in ischemic penumbra following ischemic stroke? | During the subacute phase, the irreversible damage expands into the penumbra: multiple electrical and biological signals are triggered by periinfarct, spreading depression-like depolarizations leading to hypoxia and stepwise increase in lactate., Experimental and clinical studies indicate that waves of cortical spreadi... | yes |
converted_2552 | Is the consumption of chocolate associated with an increase in cardiovascular disease? | The consumption of natural polyphenol-rich foods, and cocoa in particular, has been related to a reduced risk of CVD, including coronary heart disease and stroke., chocolate has been shown to decrease CVD risk due to its antioxidant and anti-inflammatory properties., A number of studies have shown that dietary polyphen... | no |
converted_3363 | Is bortezomib a Proteasome inhibitor? | The proteasome-inhibitor bortezomib, The proteasome inhibitor bortezomib is effective for a variety of tumors, but not for GBM. , Proteasome inhibitor bortezomib , The proteasome inhibitor bortezomib, registered for Multiple Myeloma treatment, is currently explored for activity in solid tumors including non-small cell ... | yes |
converted_1067 | Can RG7112 inhibit MDM2? | To assess the influence of the p53 regulatory pathway further, we studied the effect of RG7112, a small molecule MDM2 antagonist that activates p53 by preventing its interaction with MDM2, on normal megakaryocytopoiesis and platelet production., RG7112 (2g) is the first clinical small-molecule MDM2 inhibitor designed t... | yes |
converted_2517 | Does wheat belongs to the genus Avena, yes or no? | oat seedlings (Avena sativa), wild green-oat (Avena sativa) , Oat (Avena sativa L.), Oat (Avena sativa L.), Avena (Oats), wild oats (Avena fatua L.), oats (genus Avena), Avena sativa L. and A. byzantina C. Koch) , oat (Avena sativa L.)., oat (Avena sativa L.) and wheat (Triticum aestivum | no |
converted_4037 | Is Tocilizumab (Actemra) used to block/antagonize the IL-6 receptor? | Preliminary clinical results have indicated that antagonism of the IL-6 receptor (IL-6R), including with the FDA-approved humanized monoclonal antibody tocilizumab, can improve the outcomes of patients with severe or critical COVID-19 while maintaining a good safety profile., Tocilizumab, an anti-IL-6 receptor antibody... | yes |
converted_4368 | Does TIMELESS-TIPIN participate in replisome disassembly? | TIMELESS-TIPIN and UBXN-3 promote replisome disassembly during DNA replication termination in Caenorhabditis elegans., We show that UBXN-3 is important in vivo for replisome disassembly in the absence of TIMELESS-TIPIN. Correspondingly, co-depletion of UBXN-3 and TIMELESS causes profound synthetic lethality. Since the ... | yes |
converted_4444 | Can epigenetic modifications be heritable? | Epigenetic alterations (epimutations) could thus contribute to heritable variation within populations and be subject to evolutionary processes such as natural selection and drift. | yes |
converted_2259 | Does TUC.338 inhibit colorectal cancer? | TUC.338 promotes invasion and metastasis in colorectal cancer., Until now, the role of TUC.338 in colorectal cancers remains undefined. This study revealed that TUC.338 is significantly up-regulated in colorectal cancers (CRC) tissue and CRC cell lines, and the up-regulated TUC.338 is associated with lymph node metasta... | no |
converted_1546 | Is Rac1 involved in cancer cell invasion? | In the Matrigel invasion assay, knockdown of CCR1 and inhibition of the ERK and Rac signaling pathways significantly decreased the number of invading cells., These results demonstrated for the first time that the interaction of CCR1 with CCL5 caused by increased expression of CCR1 promotes invasion of PC3PR cells by in... | yes |
converted_4650 | Is there an association between Guillain–Barré syndrome and covid vaccine? | AstraZeneca COVID-19 vaccine and Guillain- Barré Syndrome in Tasmania: A causal link?, Nearly all reported cases of post-COVID-19 vacciation inflammatory demyelinating polyneuropathy are linked to AstraZeneca vaccination and a variant with bifacial weakness is the most reported form of GBS globally., Guillain-Barré Syn... | yes |
converted_1380 | Can chronological age be predicted by measuring telomere length? | Human somatic cells gradually lose telomeric repeats with age. This study investigated if one could use a correlation between telomere length and age, to predict the age of an individual from their DNA., Therefore, telomere length measurement by real-time quantitative PCR cannot be used to predict age of a person, due ... | no |
converted_1395 | Does prudent diet reduce cardiovascular risk? | Using this approach, large prospective studies have reported reductions in CVD risk ranging from 10 to 60% in groups whose diets can be variously classified as ‘Healthy’, ‘Prudent’, Mediterranean’ or ‘DASH compliant’., Our findings suggest that a heart healthy dietary pattern is associated with moderately reduced risk ... | yes |
converted_61 | Is c-met involved in the activation of the Akt pathway? | Amplification of MET has been reported in approximately 5%-22% of lung tumors with acquired resistance to small-molecule inhibitors of the epidermal growth factor receptor (EGFR). Resistance to EGFR inhibitors is likely mediated through downstream activation of the phosphoinositide 3-kinase /AKT pathway., Simultaneous ... | yes |
converted_1059 | Are piRNAs involved in gene silencing? | In Drosophila ovaries, the nuclear Piwi protein is required for transcriptional silencing of transposons, though the precise mechanisms by which this occurs are unknown., Here we show that the CG9754 protein is a component of Piwi complexes that functions downstream of Piwi and its binding partner, Asterix, in transcri... | yes |
converted_4168 | Are enhancers directional in their targeting of gene promoters? | Novel bi-directional duplex promoters (BDDP) were constructed by placing two identical core promoters divergently on both upstream and downstream sides of their duplicated enhancer elements., These promoters initiate transcription in opposite directions and are separated only by a short enhancer region, which is likely... | no |
converted_2036 | Is there a relationship between B cells and Multiple Sclerosis? | These results suggest that RRMS patients with radiological phenotypes showing high neurodegeneration have changes in B cells characterized by down-regulation of B-cell-specific genes and increased activation status, Although the exact etiology is still obscure, the leading hypothesis behind MS relapses is acute inflamm... | yes |
converted_3359 | Is the FIP virus thought to be a mutated strain for the Feline enteric Coronavirus? | Feline infectious peritonitis (FIP) results from mutations in the viral genome during a common feline enteric coronavirus (FECV) infection., It is caused by FIP virus (FIPV), a virulent mutant strain of Feline Enteric Coronavirus (FECV)., Feline infectious peritonitis virus (FIPV) was presumed to arise from mutations i... | yes |
converted_3371 | Does clinical trial data support the use of minocycline for amyotrophic lateral sclerosis? | Two double-blind, randomized, placebo-controlled feasibility trials of minocycline in ALS were conducted. , This pilot study shows that minocycline and riluzole can be taken safely together. Further trials are needed to assess efficacy of such treatment., It reduces apoptosis in mouse models of Huntington's disease and... | no |
converted_4366 | Is there a genetic cause of craniostenosis? | Apert syndrome - acrocephalosyndactyly - is a rare autosomal dominant disorder representing 1:65 000 cases of living newborns. Characteristic malformations of the Apert syndrome are early craniostenosis, microviscerocranium and II-V finger syndactyly of hand and toes with proximal phalanx of the bilateral thumb "in del... | yes |
converted_181 | Is the abnormal dosage of ultraconserved elements disfavored in cancer cells? | Abnormal dosage of ultraconserved elements is highly disfavored in healthy cells but not cancer cells., We begin by showing that depletion for UCEs characterizes the most recent large-scale human CNV datasets and then find that even newly formed de novo CNVs, which have passed through meiosis at most once, are signific... | no |
converted_2186 | Can acupuncture cause spinal epidural hematoma? | RESULTS: A 54-year-old woman, a 38-year-old woman, and a 60-year-old man with hemiplegia by cervical subdural or epidural hematoma after cervical posterior paraspinal muscle needling without direct invasion (intramuscular stimulation, acupuncture, or intramuscular lidocaine) were observed., Acute spinal subdural hemato... | yes |
converted_2871 | Are de novo mutations in regulatory elements responsible for neurodevelopmental disorders? | The role of de novo mutations in regulatory elements affecting genes associated with developmental disorders, or other genes, has been essentially unexplored. We identified de novo mutations in three classes of putative regulatory elements in almost 8,000 patients with developmental disorders. Here we show that de novo... | yes |
converted_672 | Is TREM2 associated with Alzheimer's disease? | Absence of TREM2 polymorphisms in patients with Alzheimer's disease and Frontotemporal Lobar Degeneration, These data demonstrate that TREM2 coding region is highly conserved, implying a crucial role of this receptor. Further studies, including a functional analysis, are certainly required to clarify the role of TREM2... | yes |
converted_2877 | Can enasidenib be used for the treatment of acute myeloid leukemia? | In August 2017, the United States Federal Drug Administration (FDA) approved enasidenib (Idhifa, Celgene/Agios) for adults with relapsed and refractory acute myelogenous leukemia (AML) with an IDH2 mutation. | yes |
converted_1383 | Is there an association between c-reactive protein concentrations and outcomes of subarachnoid hemorrhage patients? | Besides the baseline characteristics, daily interleukin-6 (IL-6), procalcitonin, C-reactive protein levels, and leukocyte counts were prospectively measured until day 14 after subarachnoid hemorrhage. Occurrence of infectious complications and application of therapeutic hypothermia were assessed as confounding factors.... | yes |
converted_2187 | Is edema a symptom of nephrotic syndrome? | Nephrotic syndrome (NS) is a common clinical disease with four main clinical manifestations: hypoalbuminemia (<30 g/L), macro-proteinuria (>3.5 g/24 h), edema, and hyperlipidemia. , Nephrotic syndrome is an unusual manifestation of IgA Nephropathy (IgAN)., Twelve patients with IgAN with steroid-responsive nephrotic syn... | yes |
converted_2420 | SGOT is an abbreviation for an enzyme other wise known as alanine amino transferase, yes or no? | patients with aspartate amino transferase (SGOT), alanine amino transferase (SGPT),, Alanine amino transferase (SGPT), , aspartate aminotransferase (AST-SGOT), alanine amino-transferase (ALT-SGPT), Mean values of glutamate dehydrogenase (GDH), serum aspartate and alanine transferase (SGOT and SGPT), ornithine carbamoyl... | no |
converted_994 | Is DNA methylation an epigenetic modification of chromatin related to gene expression? | DNA methylation is a chemical modification of DNA involved in the regulation of gene expression by controlling the access to the DNA sequence. , Epigenetic marks such as DNA methylation play important biological roles in gene expression regulation and cellular differentiation during development., DNA methylation patter... | yes |
converted_3176 | Can mitochondria pass through membrane nanotubes? | Membrane nanotubes (MNTs) act as "highways" between cells to facilitate the transfer of multiple signals and play an important role in many diseases. Our previous work reported on the transfer of mitochondria via MNTs between cardiomyocytes (CMs) and cardiac myofibroblasts (MFs), Membrane nanotubes play important funct... | yes |
converted_1171 | Is nicotinamide effective for skin cancer prevention? | Nicotinamide (vitamin B3) has been shown to have protective effects against damage caused by UV radiation and to reduce the rate of new premalignant actinic keratoses., ESULTS: At 12 months, the rate of new nonmelanoma skin cancers was lower by 23% (95% confidence interval [CI], 4 to 38) in the nicotinamide group than ... | yes |
converted_3360 | Does SATB1 regulate the RAG1 and RAG2 genes? | High level expression of the Xlr nuclear protein in immature thymocytes and colocalization with the matrix-associated region-binding SATB1 protein, Its onset preceded the rearrangement of TCR genes, as Xlr expression was conserved in thymus cells from RAG1(0/0) mice. , An anti-silencer- and SATB1-dependent chromatin h... | yes |
converted_509 | Is phospholamban a regulatory/inhibitory protein of the Ca ATPase SERCA? | The membrane protein complex between the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) and phospholamban (PLN) controls Ca(2+) transport in cardiomyocytes, thereby modulating cardiac contractility. β-Adrenergic-stimulated phosphorylation of PLN at Ser-16 enhances SERCA activity via an unknown mechanism., Phospholamban (... | yes |
converted_321 | Is exonuclease Xrn1 a component of the P-bodies? | PBs are associated with mRNA decay and contain the decapping enzymes DCP1/2, the 5' to 3' exonuclease Xrn1, the Lsm proteins (1-7), and the scaffolding proteins hedls/GE-1 and GW182. Both SGs and PBs contain mRNA, eIF4E, microRNAs and argonaute proteins, and various regulators of mRNA stability and translation (TTP, RC... | yes |
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