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values | paper_id stringlengths 10 26 | doi stringlengths 15 34 ⌀ | version int64 1 6 | title stringlengths 22 201 | authors listlengths 1 43 | license stringclasses 2
values | source_url stringlengths 35 60 | published timestamp[s]date 2021-03-03 00:00:00 2026-07-16 00:00:00 | blocks listlengths 19 529 |
|---|---|---|---|---|---|---|---|---|---|
biorxiv | 10.64898/2026.04.20.719742 | 10.64898/2026.04.20.719742 | 1 | Tensor-Derived Similarity Networks for Characterising Spatial Patterns in Colorectal Cancer | [
"Pham, T. D."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719742v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Spatial transcriptomics has emerged as a powerful technology for measuring gene expression while preserving the spatial context of tissue architecture. Unlike conventional bulk or single-cell sequencing app... |
biorxiv | 10.64898/2026.04.20.719739 | 10.64898/2026.04.20.719739 | 1 | Cellular senescence dysregulates antiviral interferon responses in idiopathic pulmonary fibrosis | [
"Hughes, J.-W. B.",
"Reisser, Y.",
"Hornung, F.",
"Hilsabeck, T. A. U.",
"Senchyna, F.",
"Coelho, A. L.",
"Ho, T.-C.",
"Schneider, K.",
"Furman, D.",
"Hogaboam, C. M.",
"Le Saux, C. J.",
"Desprez, P.-Y.",
"Deinhardt-Emmer, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719739v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible interstitial lung disease increasingly recognized as an age-associated disorder of the lung ( King et al. 2011 ; Martinez et al. 2017 ; Mah... |
biorxiv | 10.64898/2026.04.20.719731 | 10.64898/2026.04.20.719731 | 1 | Lightning Pose 3D: an uncertainty-aware framework for data-efficient multi-view animal pose estimation | [
"Aharon, L.",
"Whiteway, M. R.",
"Sikka, K.",
"Lee, K.",
"Wang, Y.",
"Chettih, S.",
"Midler, B.",
"Witten, I. B.",
"Aronov, D.",
"International Brain Laboratory,",
"Paninski, L."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719731v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Precise measurement of animal behavior is central to modern neuroscience, and pose estimation—the automatic tracking of body part locations from video—has become a foundational tool for this purpose ( Mathi... |
biorxiv | 10.64898/2026.04.20.719725 | 10.64898/2026.04.20.719725 | 1 | Circadian Disruption Drives Extracellular Matrix Remodeling to Facilitate Pulmonary Metastatic Colonization | [
"Aiello, I.",
"Hokama, G.",
"Ceci, A.",
"Senna, C.",
"Golombek, D. A.",
"Paladino, N.",
"Finkielstein, C. V."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719725v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Circadian timekeeping systems orchestrate temporal coherence across virtually all physiological and behavioral processes, from sleep-wake cycles and body temperature regulation to endocrine secretion and im... |
biorxiv | 10.64898/2026.04.20.719715 | 10.64898/2026.04.20.719715 | 1 | SpaceBender: Denoising Spatial Transcriptomics Data to Enhance Biological Signals | [
"Chen, D. G.",
"Ribas, A.",
"Campbell, K. M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719715v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Spatial transcriptomics (ST) has revolutionized our ability to interrogate human biology through its simultaneous measurement of both phenotype (e.g. transcriptome) and physical position 1 – 3 . ST technolo... |
biorxiv | 10.64898/2026.04.20.719713 | 10.64898/2026.04.20.719713 | 1 | The proximal N-terminus of IRAG is required for potentiation of HCN4 channels | [
"Blecker, L. M.",
"Teichman, E. M.",
"Peters, C. H.",
"Enders, D. J.",
"Roth, R.",
"Nichols, W. G.",
"Langley, A. A.",
"Proenza, C.",
"Bankston, J. R."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719713v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "The hyperpolarization-activated, cyclic nucleotide-sensitive (HCN) ion channels comprise a family of mixed cation channels that are activated at hyperpolarized potentials and potentiated by cyclic nucleotid... |
biorxiv | 10.64898/2026.04.20.719684 | 10.64898/2026.04.20.719684 | 1 | Autonomous multimodal agents enable transparent, spatiotemporal reconstruction of immune dynamics in pancreatic cancer progression | [
"Huang, B.",
"Zhu, B."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719684v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Pancreatic cancer remains one of the most lethal malignancies, driven in part by the clinically silent evolution of precursor lesions that undergo extensive immune and stromal reprogramming long before over... |
biorxiv | 10.64898/2026.04.20.719515 | 10.64898/2026.04.20.719515 | 1 | A comprehensive DNA methylation atlas for the Chinese population through nanopore long-read sequencing of 106 individuals | [
"Li, Y.",
"Jiang, T.",
"Qian, L.",
"Wang, Y."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719515v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "DNA methylation, a pivotal epigenetic modification, is intricately influenced by both genetic and environmental factors and plays a crucial role in environmental adaptation. Among various epigenetic marks, ... |
biorxiv | 10.64898/2026.04.20.719465 | 10.64898/2026.04.20.719465 | 1 | Using atorvastatin-induced vascular weakness to model brain haemorrhage in vascularised cerebral organoids | [
"Crilly, S.",
"Sundararaman, S.",
"Haley, M. J.",
"Segantin, E.",
"Campbell, N.",
"Lafarge, E. J.",
"Cheeseman, A.",
"Fumado Navarro, J.",
"McKernan, D.",
"Couper, K. N.",
"Lomora, M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719465v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Intracerebral haemorrhage (ICH) or haemorrhagic stroke is a leading cause of death and disability worldwide. 1 Determining pathological mechanisms and therapeutic targets depends on preclinical modelling. R... |
biorxiv | 10.64898/2026.04.20.719143 | 10.64898/2026.04.20.719143 | 1 | Spatial scale of indentation explains shift in ratio between spinal cord gray and white matter stiffness | [
"Neumann, O.",
"Surana, H. V.",
"Hintze, M.",
"Kuerten, S.",
"Franz, T.",
"Ramachandran, R. G.",
"Steinmann, P.",
"Budday, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719143v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Scientific investigations into the mechanical properties of spinal cord tissue have expanded significantly over recent decades. Despite valuable advances in the mechanical characterization of central nervou... |
biorxiv | 10.64898/2026.04.19.719299 | 10.64898/2026.04.19.719299 | 2 | Multi-omic gene regulatory networks informed by 3D chromatin architecture reveal insights into hematopoietic stem cell ageing | [
"Stacpoole, Q.",
"Allan, R. S.",
"Coughlan, H. D.",
"Iannarella, N.",
"Johanson, T. M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.19.719299v2 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Hematopoietic stem cells (HSCs) are responsible for continually replenishing the blood system with mature cells, ensuring immune competence and tissue homeostasis ( Osawa et al., 1996 ; Spangrude et al., 19... |
biorxiv | 10.64898/2026.04.18.719389 | 10.64898/2026.04.18.719389 | 2 | A stable cryogenic fluorescence microscope for correlative super-resolution light and electron microscopy | [
"Mojiri, S.",
"Dobbs, J. M.",
"Sanchez, R.",
"Kreshuk, A.",
"Mahamid, J.",
"Ries, J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.18.719389v2 | 2026-04-21T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The integration of fluorescence microscopy with electron microscopy for imaging of the same biological specimen under cryogenic conditions (cryogenic correlative light and electron microscopy, or cryo-CLEM)... |
biorxiv | 10.64898/2026.04.17.719014 | 10.64898/2026.04.17.719014 | 2 | ClonoScreen3D-CRISPRi Uncovers Genetic Modifiers of Radiation Response in Glioblastoma | [
"Lee, S.",
"Husmann, A.",
"Li, J.",
"Li, C. Z.",
"Modi, S.",
"Ahmad, S.",
"Mackay, S.",
"Paul, A.",
"Jackson, M. R.",
"Chalmers, A. J.",
"McCarthy, N.",
"Gomez-Roman, N.",
"Bello, E."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.17.719014v2 | 2026-04-21T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Glioblastoma (GBM) remains the most aggressive and lethal primary brain tumour in adults, characterized by extensive heterogeneity, rapid recurrence, and poor prognosis despite multimodal treatment 1 , 2 . ... |
biorxiv | 10.64898/2026.04.16.718670 | 10.64898/2026.04.16.718670 | 1 | Quantifying data reuse in proteomics using PRIDE downloads statistics and a semi-supervised LLM-based framework | [
"Hewapathirana, S.",
"Bai, J.",
"Bandla, C.",
"Kamatchinathan, S.",
"Kundu, D. J.",
"John, N. S.",
"Brown-Harry, B.",
"Madhusoodanan, N.",
"Riera Duocastella, J. M.",
"Vizcaino, J. A.",
"Perez-Riverol, Y."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.16.718670v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The PRIDE database is the world-leading data repository for mass spectrometry-based proteomics [ 1 ]. As a founding member of the ProteomeXchange consortium [ 2 ], PRIDE enables researchers to share and acc... |
biorxiv | 10.64898/2026.03.13.711751 | 10.64898/2026.03.13.711751 | 2 | Deep-learning-assisted simulation of a cortical circuit: integrating anatomy, physiology and function | [
"Ito, S.",
"Haufler, D.",
"Fraile, J. G.",
"Dai, K.",
"Aman, J.",
"Chen, G.",
"Mirasso, C. R.",
"Maass, W.",
"Arkhipov, A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.03.13.711751v2 | 2026-03-17T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Main"
},
{
"type": "para",
"text": "Understanding brain mechanisms, computations, and diseases requires models that bridge synapse-level organization and cellular-resolution neural dynamics. Biorealistic circuit models pursue this by systematically i... |
biorxiv | 10.64898/2026.03.13.711687 | 10.64898/2026.03.13.711687 | 2 | Eco-Evolutionary Dynamics of Proliferation Heterogeneity: A Phenotype-Structured Model for Tumor Growth and Treatment Response | [
"Schmalenstroer, L.",
"Rockne, R. C.",
"Farahpour, F."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.03.13.711687v2 | 2026-03-17T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Biological populations are inherently heterogeneous. Even genetically related individuals can differ substantially in phenotypic traits such as reproduction rate ( Travers et al. 2015 ), metabolic activity ... |
biorxiv | 10.64898/2026.03.04.709517 | 10.64898/2026.03.04.709517 | 2 | Extent of damage to descending output from cortex rather than to specific cortical regions drives the emergence of flexor synergy in non-human primates | [
"Baines, A.",
"Glover, I. S.",
"Baker, A. M.",
"Krakauer, J. W.",
"Baker, S. N."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.03.04.709517v2 | 2026-03-06T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "A stroke affecting the middle cerebral artery causes damage to the sensorimotor cortex and its descending corticofugal projections, resulting in acute contralateral hemiparesis in approximately 80% of patie... |
biorxiv | 10.64898/2026.01.28.702368 | 10.64898/2026.01.28.702368 | 2 | Molecular mechanisms of mitochondrial Ca2+ exchanger NCLX | [
"Zhang, L.",
"Han, Y.",
"Zeng, W.",
"Xue, J.",
"Wang, Y.",
"Jiang, Y."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.01.28.702368v2 | 2026-02-01T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Calcium is a critical secondary messenger in eukaryotic cells, regulating diverse processes ranging from metabolism to signal transduction 1 - 2 . Mitochondria serve as central hubs for calcium signaling, i... |
biorxiv | 10.64898/2026.01.01.697272 | 10.64898/2026.01.01.697272 | 3 | Meta-learning is expressed through altered prefrontal cortical dynamics | [
"Sun, X.",
"Comrie, A. E.",
"Kahn, A. E.",
"Monroe, E. J.",
"Washington, C. B.",
"Joshi, A.",
"Guidera, J. A.",
"Denovellis, E. L.",
"Krausz, T. A.",
"Zhou, J.",
"Thompson, P.",
"Hernandez, J.",
"Yorita, A.",
"Haque, R.",
"Pandarinath, C.",
"Berke, J. D.",
"Daw, N. D.",
"Frank, L. ... | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.01.01.697272v3 | 2026-01-02T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Main"
},
{
"type": "para",
"text": "To make adaptive decisions in a changing environment, the brain must learn to incorporate external feedback into its evaluation processes and action policies. For instance, effective foraging in the wilderness requ... |
biorxiv | 10.64898/2025.12.09.692702 | 10.64898/2025.12.09.692702 | 2 | Beyond the Brake: the Subthalamic Nucleus Predominantly Facilitates Action in Non-human Primates | [
"Yoshida, A.",
"Krauzlis, R. J.",
"Hikosaka, O."
] | CC0-1.0 | https://www.biorxiv.org/content/10.64898/2025.12.09.692702v2 | 2025-12-12T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The subthalamic nucleus (STN) is a crucial component of the basal ganglia circuitry that has traditionally been viewed as responsible for suppressing motor output, a concept rooted in classical models of th... |
biorxiv | 10.1101/2025.06.24.660794 | 10.1101/2025.06.24.660794 | 3 | A Benchmark of Modern Statistical Phasing Methods | [
"Beck, A. T.",
"Kang, H. M.",
"Zoellner, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.06.24.660794v3 | 2025-06-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "In tandem with the explosive growth of genome sequencing sample sizes, modern population-based statistical phasing methods have evolved to handle the complex task of efficiently constructing phased haplotyp... |
biorxiv | 10.1101/2025.05.30.657056 | 10.1101/2025.05.30.657056 | 3 | Multivariate pattern analysis identifies potential inter-trial resting-state EEG biomarkers in fibromyalgia | [
"Soldic, D.",
"Martin-Buro, M. C.",
"Lopez-Garcia, D.",
"del Pino, A. B.",
"Fernandes-Magalhaes, R.",
"Ferrera, D.",
"Pelaez, I.",
"Carretie, L.",
"Mercado Romero, F."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.05.30.657056v3 | 2025-06-03T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Fibromyalgia (FM) affects 2-8% of the population, predominantly women ( Clauw, 2014 ). The syndrome is characterized by widespread musculoskeletal pain and hypersensitivity, also affecting neurological, cog... |
biorxiv | 10.1101/2024.04.11.588920 | 10.1101/2024.04.11.588920 | 3 | The landscape of regional missense mutational intolerance quantified from 730,947 exomes | [
"Wang, L.",
"Chao, K. R.",
"Panchal, R.",
"Liao, C.",
"Abderrazzaq, H.",
"Ye, R.",
"Schultz, P.",
"Compitello, J.",
"Grant, R. H.",
"Kosmicki, J. A.",
"Weisburd, B.",
"Phu, W.",
"Wilson, M. W.",
"Laricchia, K. M.",
"Goodrich, J. K.",
"Goldstein, D.",
"Goldstein, J. I.",
"Vittal, C.... | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2024.04.11.588920v3 | 2024-04-13T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Main text"
},
{
"type": "para",
"text": "Over the last decade, exome and genome sequencing have enabled variant discovery across hundreds of thousands of individuals 1 – 6 . As sequencing becomes more routine in both clinical and research settings, i... |
biorxiv | 10.1101/2023.09.27.559710 | 10.1101/2023.09.27.559710 | 4 | Primate Saccade Rhythmicity | [
"Näher, T.",
"Zhang, Y.",
"Spadacenta, S.",
"Pandinelli, M.",
"Bastian, L.",
"Thier, P.",
"Hafed, Z. M.",
"Fries, P."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2023.09.27.559710v4 | 2023-09-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Vision is an active process: rather than passively receiving stimuli, organisms actively reposition their eyes to selectively sample behaviorally relevant information from the environment. In primates, sacc... |
biorxiv | 10.1101/2023.09.27.559694 | 10.1101/2023.09.27.559694 | 3 | Molecular signatures of heat tolerance in an Australian alpine plant during moderate warming | [
"Notarnicola, R. F.",
"Hamilton, J.",
"Arnold, P. A.",
"Jones, A.",
"Loke, S.",
"Feng, Z.-P.",
"Schmidt-Lebuhn, A.",
"Schwessinger, B.",
"Nicotra, A. B.",
"Ganguly, D. R."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2023.09.27.559694v3 | 2023-09-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Alpine environments, which are characterised by high spatio-temporal variability in climatic conditions including steep temperature and precipitation gradients across complex topography, are predicted to be... |
biorxiv | 10.1101/2021.03.02.433644 | 10.1101/2021.03.02.433644 | 5 | Ribosomal RNA methylation by GidB modulates discrimination of mischarged tRNA | [
"Bi, Z.",
"Chen, Y.-X.",
"Young, I. D.",
"Dandan, M. T.",
"Joshi, H.",
"Su, H.",
"Chen, Y.",
"Hong, J.",
"Fraser, J. S.",
"Javid, B."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2021.03.02.433644v5 | 2021-03-03T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "All clades of life have evolved multiple, redundant pathways to reduce translational error [ 1 , 2 ]. Despite these mechanisms, errors in protein synthesis are remarkably common and are orders of magnitude ... |
biorxiv | 10.64898/2026.04.22.720090 | 10.64898/2026.04.22.720090 | 1 | Diversification and functional expansion of archaeal TFF machineries | [
"Sivabalasarma, S.",
"Albers, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720090v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Archaea harbor versatile cell surface structures that decorate their cell envelope. Many of these structures can be classified within a superfamily of type IV filament structures (TFF)( 1 ). The TFF superfa... |
biorxiv | 10.64898/2026.04.22.720075 | 10.64898/2026.04.22.720075 | 1 | Identifying molecular instructions to hard-wire a sensory neurons synaptic connectivity | [
"dos Santos, J. V.",
"Yu, R. Y.",
"Terceros, A.",
"Pires, P. M.",
"Rusu, D.",
"Cvektkovska, V.",
"Bucio-Mendez, A.",
"Lin, T.-J.",
"Emran, F.",
"Djambazian, H.",
"Berube, P.",
"Sladek, R.",
"Chen, B. E."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720075v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Critical behaviours that are required for an animal’s survival are hard-wired into the genome. The neural circuitry underlying these innate behaviours must be pre-specified using precise molecular instructi... |
biorxiv | 10.64898/2026.04.22.719209 | 10.64898/2026.04.22.719209 | 1 | Suidae iPSC-derived macrophages as models for investigating susceptibility and resilience to African swine fever virus | [
"Watson, T. M.",
"Goatley, L. C.",
"Meek, S.",
"Eory, L.",
"Kohler, S.",
"Berkley, N.",
"Sternberg, S.",
"Jackson, M.",
"Findlay, A.",
"Hoskins, I.",
"Girling, S.",
"Mee, J.",
"Archibald, A. L.",
"Grey, F.",
"Steinbach, F.",
"Crooke, H.",
"Netherton, C. L.",
"Burdon, T."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.719209v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "ASFV is a large, ≥200 kb double stranded DNA virus of the Asfarviridae family that is present in a sylvatic cycle between warthogs ( Phacochoerus africanus ) and soft ticks ( Ornithodoros spp.), as well as ... |
biorxiv | 10.64898/2026.04.21.720024 | 10.64898/2026.04.21.720024 | 1 | A Ribosomal Marker-Based Metataxonomic Framework for Environmental Surveillance of Nematodes of Public Health Importance | [
"Zuluaga, J. P.",
"Bedoya-Urrego, K.",
"Alzate, J. F."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.720024v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Nematodes are ubiquitous metazoans found in terrestrial and aquatic habitats, parasitizing plants and animals including humans [ 1 , 2 ]. Approximately 30,000 species have been described, though total diver... |
biorxiv | 10.64898/2026.04.21.719969 | 10.64898/2026.04.21.719969 | 1 | An Interpretable 3D Bag-Of-Visual-Words Pipeline for Volumetric Microscopy Classification | [
"Pittman, A. E.",
"Campbell, K. R.",
"Laumonnerie, C.",
"Solecki, D. J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719969v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Fluorescence microscopy has transformed the study of biological systems, enabling direct visualization of subcellular structures and dynamics. However, the increasingly sophisticated imaging strategies that... |
biorxiv | 10.64898/2026.04.21.719941 | 10.64898/2026.04.21.719941 | 1 | Metagenome-assembled genomes (MAGs) revealed a functionally stratified microbiome in Jeevamrit, enabling co-operative nutrient cycling and rhizospheric growth promotion in the natural farming practices | [
"Agwan, D.",
"Jain, A. G.",
"Singh, A. S.",
"Mohapatra, B.",
"Rathod, J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719941v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The widespread application of intensive chemical fertilizers has severely compromised global soil health, driving a drastic decline in soil organic carbon, nutrient balance, and microbial diversity ( 1 ). T... |
biorxiv | 10.64898/2026.04.21.719932 | 10.64898/2026.04.21.719932 | 1 | Distinct cell-type contributions and network topography of theta-nested gamma oscillations in the medial entorhinal cortex | [
"Williams, B.",
"Dahal, R.",
"Vedururu Srinivas, A.",
"Xiao, S.",
"Moya, M. V.",
"Canavier, C. C.",
"Han, X.",
"Economo, M. N.",
"White, J. A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719932v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Neural oscillations are critical for coordinating brain activity, enabling information transfer and cognitive function across distributed networks ( Buzsáki and Draguhn, 2004 ; Fries, 2005 ; Wang, 2010 ). C... |
biorxiv | 10.64898/2026.04.21.719911 | 10.64898/2026.04.21.719911 | 1 | Nuclear Factor I genes drive chondrogenic cell-fate commitment | [
"Meulenbelt, I.",
"Mulders, R.",
"Nickel-Maunu, M.",
"van Hoolwerff, M.",
"Mazzini, G.",
"Klomp, L.",
"Meijer, H.",
"Post, J.",
"Ramos, Y."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719911v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Osteoarthritis is a painful and debilitating joint disease. Articular cartilage of the covering long bone joint facing surfaces is progressively worn down until bare bone is exposed. Currently, no effective... |
biorxiv | 10.64898/2026.04.21.719902 | 10.64898/2026.04.21.719902 | 1 | Identifying disease-causing mechanisms and fundamental biology of neuromuscular disorder genes through genomic feature analysis | [
"Martin, A.",
"Llanes-Cuesta, M. A.",
"Hartley, J. N.",
"Frosk, P.",
"Drogemoller, B. I.",
"Wright, G. E. B."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719902v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Neuromuscular disorders (NMDs) are a diverse group of conditions that affect the peripheral nervous system, including motor neurons, neuromuscular junctions, and skeletal muscle ( 1 ). Globally, an estimate... |
biorxiv | 10.64898/2026.04.21.719894 | 10.64898/2026.04.21.719894 | 2 | A novel polymerase III promoter for gene editing in the agricultural pest Ceratitis capitata | [
"Hall, A. S.",
"Shackleton-Chavez, S. M.",
"Chapman, T.",
"Leftwich, P. T."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719894v2 | 2026-04-21T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The Mediterranean fruit fly, Ceratitis capitata (medfly), is a globally significant agricultural pest within the family Tephritidae, causing damage to over 200 fruit crop species ( Christenson & Foote, 1960... |
biorxiv | 10.64898/2026.04.21.719891 | 10.64898/2026.04.21.719891 | 1 | Host tRNA modifications drive efficient translation of influenza A virus genome and impact host antiviral stress responses | [
"Ribeiro, D. R.",
"Nunes, A.",
"Monti, M.",
"Llovera, L.",
"Berg, M.",
"Kerkhoff, K.",
"Pereira, M.",
"Guimares, A. R.",
"Kaiser, S.",
"Novoa, E. M.",
"Ribeiro, D.",
"Soares, A. R."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719891v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Although genetically diverse, all viruses rely on the host cellular machinery to efficiently replicate. Among other cellular components, viruses hijack the host translation machinery, including the host tra... |
biorxiv | 10.64898/2026.04.21.719883 | 10.64898/2026.04.21.719883 | 1 | Enteroaggregative Escherichia clade I from Nigeria | [
"Dada, R. A.",
"Akinlabi, O. C.",
"Tytler, B. A.",
"Olayinka, B. O.",
"Page, A. J.",
"Thomson, N.",
"Okeke, I. N."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719883v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The genus Escherichia encompasses considerable diversity [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. Escherichia species other than E. coli were originally recognized as numbered ‘clades’. While Escherichia clade I, the... |
biorxiv | 10.64898/2026.04.21.719859 | 10.64898/2026.04.21.719859 | 1 | Bioprospecting Novel Luciferase Genes from Museum Coleoptera | [
"Bate, J.",
"Hardinge, P.",
"Jathoul, A. P.",
"Wilson, M. R.",
"Murray, J. A. H."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719859v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Bioprospecting [ 30 ] is the exploration of natural resources for commercially valuable materials such as genetic information or interesting molecules. The world’s museums contain archived specimens of pote... |
biorxiv | 10.64898/2026.04.21.719858 | 10.64898/2026.04.21.719858 | 1 | Petabase-scale Papillomavirus Discovery | [
"Shen, J.",
"Chikhi, R.",
"Korobeynikov, A.",
"Babaian, A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719858v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "heading",
"level": 2,
"text": "Using digital archives to map genetic diversity"
},
{
"type": "para",
"text": "From fundamental clinical research, to expansive ecological surveys, the use and volume of high-... |
biorxiv | 10.64898/2026.04.21.719795 | 10.64898/2026.04.21.719795 | 1 | Comparative lipidomic profiling of the livestock pathogens Trypanosoma congolense and Trypanosoma brucei | [
"Dickie, E. A.",
"Weidt, S. K.",
"Haggarty, J.",
"Blackburn, G.",
"Doherty, M. K.",
"Ritchie, R.",
"Paxton, E.",
"Young, S.",
"Whitfield, P. D.",
"Smith, T. K.",
"Barrett, M. P.",
"Morrison, L. J.",
"Steketee, P. C."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719795v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "African Animal Trypanosomosis (AAT) is a parasitic disease that poses a significant risk to the health of livestock and other animals in sub-Saharan Africa. The disease is primarily caused by three species ... |
biorxiv | 10.64898/2026.04.21.719166 | 10.64898/2026.04.21.719166 | 1 | Disparity analyses are robust to ancestral state estimation uncertainty | [
"Scutt, C. N.",
"Cooper, N.",
"Thomas, G. H.",
"Guillerme, T."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719166v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Morphological diversity, hereafter termed disparity, is widely used for investigating macroevolutionary dynamics ( Foote 1997 ; Wills 2001 ; Guillerme et al. 2020a ). Disparity can be described as the distr... |
biorxiv | 10.64898/2026.04.20.719668 | 10.64898/2026.04.20.719668 | 1 | Estimating protein isoform abundances with PAQu | [
"Testa, L.",
"Klei, L.",
"Rengle, A.",
"Yocum, A.",
"Lewis, D. A.",
"Devlin, B.",
"Roeder, K.",
"MacDonald, M. L."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719668v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Alternative splicing is a crucial post-transcriptional process ( 1 , 2 ) that generates multiple protein isoforms from a single gene, thereby contributing to the complexity of eukaryotic organisms. Dysregul... |
biorxiv | 10.64898/2026.04.20.719651 | 10.64898/2026.04.20.719651 | 1 | Extrafollicular plasma cells disable dendritic cell-T-cell priming in tumor-draining lymph nodes | [
"Alberts, E.",
"Boulat, V.",
"Hung, M. S.",
"Xu, A. Q.",
"Quist, J.",
"Li, M.",
"Liu, F.",
"Wall, I.",
"Verghese, G.",
"Brundin, C. A.",
"Bhalla, A.",
"Jonsson, M.",
"Castellanos, C.",
"Rosekilly, J.",
"GILLETT, C.",
"Staaf, J.",
"e Sousa, C. R.",
"Karagiannis, S.",
"Grigoriadis,... | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719651v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Main"
},
{
"type": "para",
"text": "Plasma cells (PCs) are classically defined as antibody-secreting factories, so their influence in cancers has largely been inferred from serology and FcγR-biology. In contrast, antibody-independent functions are le... |
biorxiv | 10.64898/2026.04.20.719650 | 10.64898/2026.04.20.719650 | 2 | Signal, Bounds, and Baselines: Principles for Evaluating Virtual Cell Perturbation Models | [
"Vollenweider, M. S.",
"Bühlmann, P."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719650v2 | 2026-04-22T00:00:00 | [
{
"type": "para",
"text": "Predicting how a cell will respond to an unseen genetic or chemical perturbation is a central goal of computational biology, with direct implications for drug discovery, functional genomics, and cell engineering. High-throughput transcriptomic screens now profile cellular response... |
biorxiv | 10.64898/2026.04.20.719649 | 10.64898/2026.04.20.719649 | 1 | Specification of the interstitial cell lineage in the fetal mouse ovary requires balanced Notch signaling | [
"Chen, Y.-Y.",
"Rattan, S.",
"Liu, C.",
"Xu, X.",
"Yao, H. H.-C."
] | CC0-1.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719649v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The mammalian ovary develops from the gonadal primordium, which can arise from the coelomic epithelium along the surface of the mesonephros around embryonic day (E) 10 in mice ( 1 , 2 ). The coelomic epithe... |
biorxiv | 10.64898/2026.04.20.719634 | 10.64898/2026.04.20.719634 | 1 | CD8scape: an accessible, command-line tool for predicting viral escape from the CD8+ T cell response | [
"Smith, E. W.",
"Hughes, J.",
"Robertson, D. L.",
"Illingworth, C."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719634v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "CD8+ T cells, otherwise known as “Killer” T cells, are an important component of the host immune response against viral infection. These recognise their antigen, usually an 8-11mer peptide sequence ( Townse... |
biorxiv | 10.64898/2026.04.20.719616 | 10.64898/2026.04.20.719616 | 1 | REVOLUTA regulates cell fate and wall patterning in the fruit endocarp | [
"Emonet, A.",
"Spatz, I.",
"Kelly, C.",
"Tikhomirov, N.",
"Dunemann, S.",
"Brombach, L.",
"Raissig, M.",
"Pauly, M.",
"Hay, A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719616v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Understanding how complex traits develop and diversify is a central question in biology. Fruit diversity reflects the wide range of strategies plants use for seed dispersal 1 , a process with important ecol... |
biorxiv | 10.64898/2026.04.20.719607 | 10.64898/2026.04.20.719607 | 1 | HMCVelo: A Deterministic Model for Hydroxymethylation Velocity in Single Cells | [
"Mishra, P."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719607v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Every cell carries, in the chemical modifications of its DNA, a continuous record of where it has been and a set of instructions for where it is going. To read this record directly — rather than through the... |
biorxiv | 10.64898/2026.04.20.719590 | 10.64898/2026.04.20.719590 | 1 | Systematic Benchmarking of Kinase Bioactivity Models Across Splitting Strategies and Protein Representations | [
"Abbott, J. M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719590v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Protein kinases constitute one of the most therapeutically important target families in drug discovery, with over 70 FDA-approved kinase inhibitors as of 2024, primarily for oncology and inflammatory diseas... |
biorxiv | 10.64898/2026.04.20.719584 | 10.64898/2026.04.20.719584 | 1 | A deep genetic structure phylogenomically frames the closest algal relatives of land plants | [
"Bierenbroodspot, M. J.",
"Kunz, C. F.",
"Goldbecker, E. S.",
"Lorenz, M.",
"Irisarri, I.",
"Proeschold, T.",
"Darienko, T.",
"de Vries, J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719584v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Main"
},
{
"type": "para",
"text": "As the closest algal relatives of land plants, Zygnematophyceae have attracted considerable attention from the plant evo-devo community in recent years 14 - 16 . The class Zygnematophyceae was established by Round ... |
biorxiv | 10.64898/2026.04.20.719579 | 10.64898/2026.04.20.719579 | 1 | Understanding cryptic diversity within the honeypot ant species complex of Myrmecocystus mendax | [
"Wolf, M.",
"Rensing, N.",
"Neuhaus, H.",
"van Elst, T.",
"Eriksson, T. H.",
"Borowiec, M.",
"Ward, P. S.",
"Johnson, R. A.",
"Gardau, J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719579v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The concept of cryptic species has been a part of the scientific discourse for almost 300 years ( Bickford et al. 2007 ). The term generally describes a group of species that have been treated as a single n... |
biorxiv | 10.64898/2026.04.20.719572 | 10.64898/2026.04.20.719572 | 1 | Dual-Layer Serological Encoding: Integrating Pathogen-Derived and Host-Reactive Peptide Signatures Reveals Complementary Dimensions of HIV Immune Response | [
"Schmidt, D.",
"Biniaminov, S.",
"Biniaminov, N.",
"von Bojnicic-Kninski, C.",
"Popov, R.",
"Maier, J.",
"Bernauer, H.",
"Griesbaum, J.",
"Schneiderhan-Marra, N.",
"Dulovic, A.",
"Nesterov-Mueller, A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719572v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Serological diagnostics have historically been grounded in antigen specificity, relying on pathogen-derived proteins to detect corresponding antibody responses. In HIV infection, fourth-generation immunoass... |
biorxiv | 10.64898/2026.04.20.719566 | 10.64898/2026.04.20.719566 | 1 | A narrow thermodynamic design window governs selective membrane permeabilization and antiviral activity of amphipathic peptides | [
"Hilten, N. v.",
"Maltitz, P. v.",
"Aschmann, D.",
"Hoernke, M.",
"Krebs, M.",
"Methorst, J.",
"Kros, A.",
"Münch, J.",
"Risselada, H. J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719566v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Viruses can be broadly classified into non-enveloped (naked) viruses, which consist solely of a protein capsid enclosing the viral genome, and enveloped viruses, which are surrounded by a lipid bilayer deri... |
biorxiv | 10.64898/2026.04.20.719559 | 10.64898/2026.04.20.719559 | 1 | Spectral emission profile and wavelength tolerances affect pulse oximeter performance | [
"Reiser, M.",
"Breidenassel, A.",
"Amft, O."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719559v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Photoplethysmography (PPG) is a widely used non-invasive optical method to measure pulsatile changes in blood volume caused by the heartbeat. Reflective PPG measurements are increasingly relevant due to the... |
biorxiv | 10.64898/2026.04.20.719558 | 10.64898/2026.04.20.719558 | 1 | A broad-host-range Rhizobium rhizogenes strain enables transient expression across diverse crops and establishes functional assays in faba bean | [
"King, F.",
"Lopez-Agudelo, J. C.",
"Stephens, C.",
"Aung, M. H.",
"Ibrahim, T.",
"Yuen, E. L. H.",
"Chen, A.",
"Eilmann, N. M.",
"Jenkins, S.",
"Vuolo, C.",
"Swee, Y.-N.",
"Liu, W.-J.",
"Bruty, S.",
"Toghani, A.",
"Kuo, C.-H.",
"Lai, E.-M.",
"Kourelis, J.",
"Derevnina, L.",
"Wu,... | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719558v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Advances in genomics and computational biology, including protein structure prediction and large-scale genomic analyses, are rapidly accelerating hypothesis generation in the plant sciences. Yet the capacit... |
biorxiv | 10.64898/2026.04.20.719551 | 10.64898/2026.04.20.719551 | 2 | A phylogenetic approach reveals evolutionary aspects and novel genes of bradyzoite conversion in Toxoplasma gondii | [
"C A, A.",
"Upadhayay, R.",
"Patankar, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719551v2 | 2026-04-21T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Toxoplasma gondii is an obligate intracellular parasite of the phylum Apicomplexa that infects warm-blooded animals, including economically important livestock ( Jacobs, 1957 ). A third of the human populat... |
biorxiv | 10.64898/2026.04.20.719548 | 10.64898/2026.04.20.719548 | 1 | Repurposed COMT Inhibitors Tolcapone and Entacapone Selectively Suppress Aggregation and Seeding of P301 Mutant TAU in Human Neuronal Models | [
"Kozlov, I.",
"Hung, Y.-S.",
"Roy, S.",
"Goud, A. C.",
"Kouril, R.",
"Wong, Y.-H.",
"Das, V."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719548v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Intracellular aggregation of the microtubule-associated protein TAU defines tauopathies ( Strang et al., 2019 ). This pathology emerges early, spreading progressively through neuronal networks in a prion-li... |
biorxiv | 10.64898/2026.04.20.719545 | 10.64898/2026.04.20.719545 | 1 | Translational toolkit for reproducible, cross-study profiling of human ageing hallmarks in human blood and tissue | [
"Tomkova, K.",
"Lewis, J. W.",
"nicholson, T. A.",
"Acharjee, A.",
"Anderson, A.",
"Barlow, J. P.",
"Frost, K.",
"Jackson, T.",
"de Magalhaes, J. P.",
"Mondal, S.",
"Naylor, A. J.",
"Nixon, A. V.",
"Rattray, N. J.",
"Rudzinska, P.",
"Veiga Sardeli, A.",
"Steves, C.",
"Welch, C.",
"... | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719545v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Global increases in lifespan have not been matched by equivalent gains in health-span, leading to an increasing prevalence of multimorbidity and age-related disease, with major socioeconomic and healthcare ... |
biorxiv | 10.64898/2026.04.20.719544 | 10.64898/2026.04.20.719544 | 1 | Protein inverse folding through joint modeling of surface and backbone geometry | [
"hong, y.",
"cai, y.",
"jiao, y.",
"qi, m.",
"Huang, Q.",
"Sun, L."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719544v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Proteins perform essential functions across nearly all biological processes, and these functions are fundamentally determined by their three-dimensional structures [ 1 ]. Consequently, the design of amino a... |
biorxiv | 10.64898/2026.04.20.719538 | 10.64898/2026.04.20.719538 | 1 | Human-supervised Agentic AI for Hypothesis Generation and Experimental Assistance in Drug Repurposing | [
"Huynh, D.-L.",
"Asp, E.",
"Ballante, F.",
"Puigvert, J. C.",
"DeGrave, A.",
"Karki, R.",
"Nader, K.",
"Östling, P.",
"Pokharel, B.",
"Rietdijk, J.",
"Schlotawa, L.",
"Schmidt, L.",
"Seal, S.",
"Seashore-Ludlow, B.",
"Aittokallio, T.",
"Spjuth, O."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719538v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Main"
},
{
"type": "para",
"text": "Drug repurposing - the systematic identification of new indications for existing approved drugs - has emerged as a productive strategy within drug discovery, offering shorter development timelines and reduced costs... |
biorxiv | 10.64898/2026.04.20.719483 | 10.64898/2026.04.20.719483 | 1 | Distinct Modulatory Effects on Affective Biases by Different Serotonergic Psychedelics and MDMA in Male Rats: Possible Implications for Antidepressant Effects | [
"Hinchcliffe, J.",
"Bartlett, J.",
"Thomas, C.",
"Golden, C.",
"Bortolotto, Z.",
"Gilmour, G.",
"Robinson, E."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719483v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The number of patients seeking treatment for mental health conditions has risen dramatically in the last decade, exacerbated by the COVID-19 pandemic ( 1 ). Current pharmacological treatments remain limited... |
biorxiv | 10.64898/2026.04.20.719310 | 10.64898/2026.04.20.719310 | 1 | When Noise Isnt Simply Noise: Deterministic Postural Drive During Noisy Galvanic Vestibular Stimulation (nGVS) | [
"Rice, D.",
"Dakin, C. J.",
"Ewer, M.",
"Hannan, K. B."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719310v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "A contributor to falls in older adults and in patients with vestibular processing disorders is deterioration of the vestibular hair cells that sense motion, along with atrophy and desensitization of vestibu... |
biorxiv | 10.64898/2026.04.20.719002 | 10.64898/2026.04.20.719002 | 1 | α-Synuclein Facilitates Spontaneous Dopamine Release in a Calcium- and Phosphorylation-Dependent Manner | [
"Feng, Y.",
"Stephens, A. D.",
"Vallejo Ramirez, P.",
"Mosharov, E. V.",
"De Simone, A.",
"Fusco, G.",
"Makarchuk, S.",
"Brockhoff, M.",
"Fernandez-Villegas, A.",
"Hockings, C.",
"Ward, E.",
"Magalhaes, P.",
"Kumar, S.",
"Läubli, N. F.",
"Lashuel, H. A.",
"Kaminski, C. F.",
"Kaminsk... | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719002v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Despite nearly four decades of research linking α-synuclein (aSyn) to the pathogenesis of Parkinson’s disease (PD), its presynaptic organisation, interactions, and functions in the native cellular environme... |
biorxiv | 10.64898/2026.04.20.718838 | 10.64898/2026.04.20.718838 | 1 | Participant engagement and feedback in microbiome projects: a case of AWI-Gen 2 | [
"Nkera-Gutabara, C.",
"Olubayo, L. A. I.",
"Oduaran, O. H.",
"Kisiangani, I.",
"Khoza, S.",
"Gama, K.",
"Maritze, M.",
"Mabunda, C.",
"Keya, D.",
"Adetunji, K. E.",
"Tollman, S.",
"Micklesfield, L. K.",
"Mohamed, S. F.",
"Gomez-Olive, F. X.",
"Tluway, F.",
"Ramsay, M.",
"Bhatt, A. S.... | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.718838v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Participant engagement in research involving biological samples or personal data is both ethically imperative and operationally essential. It fosters trust, encourages participation in future projects, and ... |
biorxiv | 10.64898/2026.04.19.719533 | 10.64898/2026.04.19.719533 | 1 | Task-induced topological and geometrical changes in whole-brain dynamics predict cognitive individual differences | [
"Chen, R.",
"Song, H.",
"Ching, S.",
"Braver, T. S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.19.719533v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The last three decades have witnessed amazing growth in cognitive neuroscience research, due in large part to advances in the use of functional magnetic resonance imaging (fMRI) neuroimaging techniques. His... |
biorxiv | 10.64898/2026.04.19.719517 | 10.64898/2026.04.19.719517 | 1 | Visualization of peripheral nerves in developing and regenerating limbs using a novel peripherin reporter line of Xenopus laevis | [
"Suzuki, M.",
"Kato, Y.",
"Mizuno, R.",
"Yajima, H.",
"Miura, S.",
"Endo, T.",
"Mochii, M.",
"Suzuki, K.-i. T."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.19.719517v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Peripherin ( PRPH ) is a class III intermediate filament protein ( Portier et al., 1983 ) that is expressed in the peripheral nervous system (PNS), particularly in sensory and autonomic neurons ( Brody et a... |
biorxiv | 10.64898/2026.04.19.719516 | 10.64898/2026.04.19.719516 | 1 | CACNA1C as a Prognostic Biomarker and Therapeutic Target in High-Grade Serous Ovarian Cancer: Clinical Validation and Molecular Dynamics of Nifedipine Blockade | [
"HAMMAD, M.",
"Wu, K.",
"Saad, E.",
"Aboody, K.",
"Chang, C.-e."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.19.719516v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Ovarian cancer (OC) ranks as the third most prevalent gynecologic malignancy globally, with 239,000 new cases each year, representing 152,000 deaths worldwide ( 1 ). It is the deadliest of all female reprod... |
biorxiv | 10.64898/2026.04.19.719506 | 10.64898/2026.04.19.719506 | 1 | Predictability of evoked activity governs the geometry of spontaneous neural manifolds | [
"Asabuki, T.",
"Clopath, C."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.19.719506v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Spontaneous neural activity, also known as ongoing activity, observed even in the absence of sensory input, is now recognized as a fundamental component of neural computation rather than mere background noi... |
biorxiv | 10.64898/2026.04.19.719496 | 10.64898/2026.04.19.719496 | 1 | BioEngine: scalable execution and adaptation of bioimage AI through agent-readable interfaces | [
"Mechtel, N.",
"Källander, H. D.",
"Cheng, S.",
"Zhang, H.",
"AI4Life Horizon Europe Program Consortium,",
"Ouyang, W."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.19.719496v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Public repositories and foundation models have substantially expanded the menu of bioimage AI: the BioImage Model Zoo 1 hosts hundreds of curated, FAIR-validated models, accessible training platforms 6 , 7 ... |
biorxiv | 10.64898/2026.04.19.719466 | 10.64898/2026.04.19.719466 | 1 | Stable isotopes (δ13C, δ15N, δ34S) suggest eelgrass (Zostera sp.) foddering of Late Iron Age sheep (Ovis aries) in Denmark | [
"Jaeger, J. H.",
"Tarrant, D.",
"Richards, M. P.",
"Ulriksen, J.",
"Sarauw, T.",
"Kastholm, O. T.",
"Nielsen, J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.19.719466v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Sheep ( Ovis aries ) have been a common livestock species in Southern Scandinavia since the Early Neolithic ( Groß et al., 2024 ; Sørensen, 2014 ). During the Bronze Age, new woolly sheep breeds were introd... |
biorxiv | 10.64898/2026.04.19.719464 | 10.64898/2026.04.19.719464 | 1 | Mitochondrial genomes reveal maternal lineages of Late Iron Age sheep (Ovis aries) in Denmark | [
"Jaeger, J. H.",
"Mattiangeli, V.",
"Ulriksen, J.",
"Sarauw, T.",
"Jessen, M. D."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.19.719464v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Sheep ( Ovis aries ) were domesticated in Southwest Asia by approximately 8,000 BC ( Daly et al., 2025 ; Kaptan et al., 2024 ; Vigne, 2011 ; Zeder, 2008 ) and subsequently dispersed across Europe through a ... |
biorxiv | 10.64898/2026.04.19.719461 | 10.64898/2026.04.19.719461 | 1 | Gut Microbiome as a Diagnostic Biomarker for Early Cancer Detection: A Systematic Review and Meta-Analysis of 18 Studies across Five Cancer Types | [
"TALL, M. l."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.19.719461v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Cancer remains the second leading cause of mortality worldwide, with over 19.3 million new cases annually [WHO, 2024]. A critical barrier to improved outcomes is the absence of cost-effective, non-invasive ... |
biorxiv | 10.64898/2026.04.19.719454 | 10.64898/2026.04.19.719454 | 1 | Expanding P-NET, a multi-purpose biologically informed deep learning framework | [
"Elmarakeby, H.",
"Glettig, M.",
"Zhou, A.",
"Zhou, C.",
"Tarantino, G.",
"Aprati, T.",
"Van Allen, E.",
"Liu, D."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.19.719454v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "In recent years, deep learning has emerged as a powerful tool for analyzing complex biological data and has revolutionized various domains of computational biology. The integration of deep learning techniqu... |
biorxiv | 10.64898/2026.04.19.719433 | 10.64898/2026.04.19.719433 | 1 | Wdr62 and Patronin cooperate to organize distinct acentrosomal microtubule networks during Drosophila oogenesis | [
"Cabrita, J.",
"Ferreira-Silva, A.",
"Pereira, T.",
"Pimenta-Marques, A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.19.719433v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Tight regulation of the microtubule (MT) cytoskeleton is essential for key cellular functions, including cell shape, polarity, migration, and division 1 , 2 . The geometry of MT networks critically depends ... |
biorxiv | 10.64898/2026.04.19.719429 | 10.64898/2026.04.19.719429 | 1 | A Closer-to-Brain Heterosynaptic Learning Rule for Spatiotemporal Spike Pattern Detection with Low-Resolution Synapse | [
"Furuichi, S.",
"Kohno, T."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.19.719429v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "In recent years, artificial intelligence (AI) technologies based on deep learning have advanced rapidly, supported by improvements in the power of computing systems and the availability of big data. However... |
biorxiv | 10.64898/2026.04.19.719365 | 10.64898/2026.04.19.719365 | 3 | Dissociable Contributions of the Right Dorsolateral Prefrontal and Posterior Parietal Cortices to Automatic Alcohol Approach Tendencies | [
"Verma, A. K.",
"Kumar, A. D.",
"Chivukula, U.",
"Kumar, N."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.19.719365v3 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Automatic alcohol approach tendencies are one of the major determinants of harmful alcohol use and have been consistently associated with relapse risk and treatment outcomes ( Barkby et al., 2012 ; Bowley e... |
biorxiv | 10.64898/2026.04.19.719203 | 10.64898/2026.04.19.719203 | 1 | Ultra-high field microstructural MRI of living cortical organoids | [
"Nikolaeva, T.",
"Jakobs, C. E.",
"Yon, M.",
"Adolfs, Y.",
"Singer, R.",
"Pasterkamp, R. J.",
"Krug, J. R.",
"Tax, C. M. W."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.19.719203v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Non-invasive and non-destructive imaging techniques of biological tissues are essential to study structure and function without disrupting their 3D architecture and metabolic processes. In this context, mag... |
biorxiv | 10.64898/2026.04.19.719088 | 10.64898/2026.04.19.719088 | 1 | CXCL10 drives female-specific tau pathology progression and defines sex-dependent vulnerability in tauopathy model mice | [
"Uenishi, R.",
"Kawata, R.",
"Manabe, T.",
"Matsuba, Y.",
"Mihira, N.",
"Takeo, T.",
"Sado, T. C.",
"Hijioka, M.",
"Saito, T."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.19.719088v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Tauopathies are neurodegenerative disorders characterized by the abnormal accumulation of hyperphosphorylated and otherwise post-translationally modified tau protein within neurons and glial cells. These pa... |
biorxiv | 10.64898/2026.04.19.718092 | 10.64898/2026.04.19.718092 | 1 | Network-based integration of cross-dataset proteomic profiles using fold-change directionality | [
"Nishizaki, M.",
"Araki, N.",
"Kawano, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.19.718092v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Proteomics aims to comprehensively characterize proteins with protein abundances, modifications, and interaction networks in biological systems and plays a key role in identifying cellular mechanisms, disea... |
biorxiv | 10.64898/2026.04.18.719419 | 10.64898/2026.04.18.719419 | 2 | A joint metabolic-integrative regime of consciousness: evidence from FDG-PET and TMS-EEG | [
"Shivashanmugam, T.",
"Mehta, A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.18.719419v2 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Identifying the biological conditions that support conscious experience remains a central challenge in neuroscience ( Seth and Bayne, 2022 ). While substantial progress has been made in characterising neura... |
biorxiv | 10.64898/2026.04.18.719392 | 10.64898/2026.04.18.719392 | 1 | Systematic identification of chromatin organizers as tuners of intratumoral heterogeneity | [
"Woo, B. J.",
"Sobti, S.",
"Suh, J. M.",
"Yousefi, H.",
"Garcia, K.",
"Zhou, S.",
"Borah, A.",
"Goodarzi, H."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.18.719392v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Intratumoral heterogeneity—cell-to-cell variation within a single tumor—is a central driver of tumor progression, therapeutic resistance, and recurrence 1 – 7 . Although targeted molecular and immunological... |
biorxiv | 10.64898/2026.04.18.719387 | 10.64898/2026.04.18.719387 | 1 | Booster vaccination improves the durability of antibody-secreting plasma cells | [
"Xu, A. Q.",
"Hung, M. S.",
"Chen, B.",
"Sopena, M. L.",
"Chakravarty, P.",
"Camara, A.",
"Calado, D. P."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.18.719387v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Public hesitancy toward booster vaccination is rising 1 – 3 . Compared with primary vaccination, willingness to receive additional doses has fallen markedly, with >50% increases in hesitancy reported in som... |
biorxiv | 10.64898/2026.04.18.719385 | 10.64898/2026.04.18.719385 | 1 | Walk-sum theoretical generators predict medial-temporal coupling driven by empirical cross-frequency generators: a novel joint cortical-subcortical approach in human sleep EEG | [
"Kafetzopoulos, V."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.18.719385v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The network view of the brain rests on two complementary analytical traditions: structural connectomics, which treats the brain as a fixed wiring diagram, and functional connectivity, which measures statist... |
biorxiv | 10.64898/2026.04.18.719383 | 10.64898/2026.04.18.719383 | 1 | BioAutoML-FAST: an automated machine-learning platform for reusable and benchmarked biological sequence models | [
"Silva de Almeida, B. L.",
"Bonidia, R.",
"Bole, M.",
"Avila-Santos, A.",
"Stadler, P. F.",
"Nunes da Rocha, U.",
"de Carvalho, A. C. P. L. F."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.18.719383v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The accurate functional and activity annotation of DNA, RNA, and protein sequences remains a significant challenge in the omics era, as high-throughput sequencing has produced data at a pace far exceeding e... |
biorxiv | 10.64898/2026.04.18.719342 | 10.64898/2026.04.18.719342 | 1 | Comparative anatomy of the giraffe distal limb | [
"Wilhite, D. R.",
"Miller, D.",
"Schilz, A.",
"Brown, M. B.",
"Fennessy, J.",
"Fennessy, S.",
"Newman, K."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.18.719342v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Approximately 1,000 giraffe ( Giraffa spp. ) are believed to be in human care in the United States of America, and over 2,000 giraffe worldwide [ 1 ]. More specifically, the studbooks indicate giraffe are d... |
biorxiv | 10.64898/2026.04.18.719337 | 10.64898/2026.04.18.719337 | 1 | A recurrent neural network model of chronic pain development and recovery | [
"Huang, K.",
"Marmor, G.",
"van der Molen, T.",
"Zhang, Z.",
"Gicqueau, P.",
"Reveles, J.",
"Morrissey, K.",
"Tang, J.",
"Lu, L.",
"Ilmi, K.",
"Lue, J.",
"Barba Zuniga, G.",
"Miller, M. B.",
"Kosik, K. S.",
"Yang, H.",
"Santander, T.",
"Bullo, F.",
"Hansma, P. K."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.18.719337v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The recent success of Pain Reprocessing Therapy (PRT) in reducing chronic pain ( 1 – 4 ) raises the question of how the relatively rapid reductions in long-term chronic pain can occur with non-pharmacologic... |
biorxiv | 10.64898/2026.04.17.719246 | 10.64898/2026.04.17.719246 | 1 | Evaluating Expert Specialization in Mixture-of-Experts Antibody Language Models | [
"Burbach, S. M.",
"Spandau, S.",
"Hurtado, J.",
"Briney, B."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.17.719246v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "I ntroduction"
},
{
"type": "para",
"text": "The development of the transformer architecture ( Vaswani et al., 2017 ) in 2017 sparked a flurry of work training language models (LMs) for natural language processing (NLP). Much like the way that the wo... |
biorxiv | 10.64898/2026.04.17.719187 | 10.64898/2026.04.17.719187 | 4 | In silico model of axonal pathfinding during spinal cord regeneration in zebrafish larvae | [
"Neumann, O. F.",
"Kravikass, M.",
"John, N.",
"Ramachandran, R. G.",
"Steinmann, P.",
"Zaburdaev, V.",
"Wehner, D.",
"Budday, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.17.719187v4 | 2026-04-21T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Following spinal cord injury (SCI), axon regeneration fails in humans and most other mammals but occurs robustly in zebrafish, enabling functional recovery [ 1 , 2 ]. Emerging evidence indicates that differ... |
biorxiv | 10.64898/2026.04.17.719089 | 10.64898/2026.04.17.719089 | 3 | Integrated Single-Cell and Spatial Profiling of MMP Gene Expression in Colorectal Cancer | [
"Danese, N. A.",
"Kurkcu, S. R.",
"Bleiler, M.",
"Nito, K.",
"Kuo, A.",
"Rosenberg, D. W.",
"Nakanishi, M.",
"Giardina, C."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.17.719089v3 | 2026-04-21T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Colorectal cancer (CRC) is the third most commonly diagnosed malignancy worldwide and a leading cause of cancer-related mortality, with an estimated 1.9 million new cases and over 900,000 deaths annually [ ... |
biorxiv | 10.64898/2026.04.16.719066 | 10.64898/2026.04.16.719066 | 1 | Parametric Physics-Based Synthesis of 3D Fluorescence Organoid Images with Exact Ground Truth for Deep Learning Pipeline Development | [
"Bhattiprolu, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.16.719066v1 | 2026-04-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "heading",
"level": 2,
"text": "The organoid imaging challenge"
},
{
"type": "para",
"text": "Three-dimensional organoid culture systems have transformed biomedical research over the past decade. First descr... |
biorxiv | 10.64898/2026.04.07.717084 | 10.64898/2026.04.07.717084 | 3 | A Hierarchical Spatial Graph Neural Network Resolves Immunogenic and Tolerogenic Tertiary Lymphoid Structures in Renal Cell Carcinoma | [
"Peng, G."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.07.717084v3 | 2026-04-08T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Tertiary lymphoid structures are ectopic lymphoid organs that assemble within chronically inflamed tissues, including solid tumours ( Sautès-Fridman et al. 2019 ; Schumacher and Thommen 2022 ). Three landma... |
biorxiv | 10.64898/2026.03.31.714748 | 10.64898/2026.03.31.714748 | 2 | A reference genome assembly for Quercus canariensis Willd | [
"Couturier, F.",
"Cravero, C.",
"Lesur, I.",
"Confais, J.",
"Belmonte, E.",
"Piat, L.",
"Marande, W.",
"Rellstab, C.",
"Valbuena, M.",
"Saez-Laguna, E.",
"Duvaux, L."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.03.31.714748v2 | 2026-04-01T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Background"
},
{
"type": "para",
"text": "European forests are experiencing increasing pressure from recurrent droughts and heatwaves, leading to widespread decline in both coniferous and deciduous tree populations, including European white oaks ( Br... |
biorxiv | 10.1101/2025.10.13.678797 | 10.1101/2025.10.13.678797 | 2 | Genotype-phenotype modeling of light ecotypes in Prochlorococcus reveals genomic signatures of ecotypic divergence | [
"Brenner, E. P.",
"Vang, C. K.",
"Johnson, C. G.",
"Ravi, J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.10.13.678797v2 | 2025-10-14T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Prochlorococcus , an ancient cyanobacterial genus 1 , is the most abundant photosynthetic organism in the ocean 2 . Its energy expenditure constitutes a major fraction of global carbon cycling 2 . These bac... |
biorxiv | 10.1101/2025.04.04.647196 | 10.1101/2025.04.04.647196 | 2 | Cell-to-cell signalling mediated via CO2: activity dependent axonal CO2 production opens Cx32 in the Schwann cell paranode. | [
"Butler, J.",
"Mott, L.",
"Bhandare, A.",
"Brown, A.",
"Dale, N."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.04.04.647196v2 | 2025-04-05T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Connexin32 (Cx32) is expressed in Schwann cells and oligodendrocytes, the myelinating cells of the peripheral and central nervous system, respectively. These cells wrap around axons to form the myelin sheat... |
biorxiv | 10.1101/2024.10.14.618165 | 10.1101/2024.10.14.618165 | 3 | Human Brain-Wide Activation of Sleep Rhythms | [
"Wang, H.",
"Zou, Q.",
"Zhang, J.",
"Gao, J.-H.",
"Liu, Y."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2024.10.14.618165v3 | 2024-10-16T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "During sleep, the human brain engages in highly synchronized activity driven by distinct neural rhythms. In non-rapid eye movement (NREM) sleep, the emergence and coordination of slow oscillations (SOs) and... |
biorxiv | 10.1101/2024.05.24.595268 | 10.1101/2024.05.24.595268 | 3 | ALPARC: Artificial Languages with Phonological and Acoustic Rhythmicity Controls | [
"Titone, L.",
"Milosevic, N.",
"Meyer, L."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2024.05.24.595268v3 | 2024-05-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Statistical learning (SL) is the ability to extract regularities from the environment. Among its role for several cognitive functions, SL is pivotal for speech segmentation and language acquisition ( Bogaer... |
biorxiv | 10.64898/2026.04.21.719790 | 10.64898/2026.04.21.719790 | 1 | HIV-1 can undergo Env-independent retrotransposon-like activity | [
"Matsumura, S.",
"Amesimeku, W. A. O.",
"Rajib, S. A.",
"Monde, N.",
"Sasaki, H.",
"Terasawa, H.",
"Hossain, M. J.",
"Sawa, T.",
"Maeda, Y.",
"Satou, Y.",
"Monde, K."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719790v1 | 2026-04-21T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Retroviruses replicate by reverse transcribing their RNA genomes into cDNA and integrating the cDNA into the host genome [ 1 - 3 ]. HIV-1, an exogenous retrovirus, generates new particles from transcripts d... |
biorxiv | 10.64898/2026.04.21.719556 | 10.64898/2026.04.21.719556 | 1 | Analysis of a detoxified Escherichia coli strain for bacteriophage production | [
"Welham, E.",
"Park de la Torriente, A.",
"Arng Lee, J.",
"Keith, M.",
"McAteer, S. P.",
"Paterson, G. K.",
"Gally, D. L.",
"Low, A. S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719556v1 | 2026-04-21T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Bacteriophage (phage) are abundant viruses that exploit the cellular machinery of their bacterial hosts to replicate and produce progeny ( 1 ). The rise in multidrug resistance (MDR) has reignited interest ... |
biorxiv | 10.64898/2026.04.21.715327 | 10.64898/2026.04.21.715327 | 1 | PathPinpointR: Predicting the progression of sc-RNAseq samples through reference trajectories. | [
"Nicholas, M. T.",
"Mehta, D.",
"Ouyang, J.",
"Dawoud, A.",
"Ellison, C.",
"Westendorf, J.",
"Green, L. A.",
"Skipp, P.",
"Rackham, O."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.715327v1 | 2026-04-21T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Single-cell RNA sequencing (scRNA-seq) has become essential for exploring cellular heterogeneity. It provides a high-resolution view of processes such as cell development or disease progression. Recent inte... |
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