source stringclasses 2
values | paper_id stringlengths 10 26 | doi stringlengths 15 34 ⌀ | version int64 1 6 | title stringlengths 22 201 | authors listlengths 1 43 | license stringclasses 2
values | source_url stringlengths 35 60 | published timestamp[s]date 2021-03-03 00:00:00 2026-07-16 00:00:00 | blocks listlengths 19 529 |
|---|---|---|---|---|---|---|---|---|---|
biorxiv | 10.64898/2026.04.22.720005 | 10.64898/2026.04.22.720005 | 2 | Tracking the Fidelity of Internal Neural Representations with Error-In-Variables Regression | [
"Garon, I.",
"Keeley, S.",
"Williams, A. H."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720005v2 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Neuroscientists are interested in identifying sensory and behavioral variables that correlate with neural activity. However, these correlations are often imperfect constructs. For example, internal represen... |
biorxiv | 10.64898/2026.04.22.719970 | 10.64898/2026.04.22.719970 | 1 | Multiscale volume electron microscopy of the human liver maps vascular-cellular architecture, organelle dynamics and inter-organelle communication | [
"Xing, C.",
"Xie, R.",
"Mulcahy, B.",
"Darbandi, A.",
"Thoeni, C.",
"Chandok, I.",
"Lee, Y.",
"Ma, J.",
"Ali, F.",
"McGilvray, I.",
"MacParland, S.",
"Zhen, M.",
"Bader, G."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.719970v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The human liver performs essential metabolic functions including detoxification, nutrient processing, and bile production [ 1 ]. These diverse processes depend on intricate multiscale organization, where st... |
biorxiv | 10.64898/2026.04.22.719922 | 10.64898/2026.04.22.719922 | 1 | Biomimetic miR-133a inhibitor activated scaffolds optimised for spinal cord repair promote neurite outgrowth and angiogenesis via neuronal cytoskeletal remodelling | [
"O'Connor, C.",
"Mullally, R.",
"Palomeque-Chavez, J. C.",
"Dobricic, M.",
"McCoy, E.",
"Maughan, J.",
"Stewart, R.",
"Saha, C.",
"O'Sullivan, J.",
"McCarthy, H. O.",
"Caldwell, M. A.",
"Prehn, J. H. M.",
"O'Brien, F. J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.719922v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Spinal cord injury (SCI) is a traumatic injury where a lesion cavity develops, host neurons are lost and spared injured neurons cannot regrow[ 1 ]. These neurons cannot regrow their damaged axons in part du... |
biorxiv | 10.64898/2026.04.22.719865 | 10.64898/2026.04.22.719865 | 1 | Large-scale transcriptomic meta-analysis identifies novel therapeutic targets for ulcerative colitis | [
"Piernik, M.",
"Adamiec-Organisciok, M.",
"Skonieczna, M.",
"Eder, P."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.719865v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized by mucosal inflammation of the colon, typically beginning in the rectum and extending continuously ( 1 ). The disease foll... |
biorxiv | 10.64898/2026.04.22.719836 | 10.64898/2026.04.22.719836 | 1 | Validated microsatellite markers for Gyrodactylus salaris: a toolkit for individual identification and genetic studies | [
"Aisala, H.",
"Hansen, H.",
"Lumme, J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.719836v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Genome-wide methods such as whole-genome sequencing/resequencing, reduced-representation libraries (e.g. RAD/GBS), and large SNP panels are now widely used in population and conservation genetics ( Allendor... |
biorxiv | 10.64898/2026.04.22.719835 | 10.64898/2026.04.22.719835 | 1 | GATA transcription factors act as gatekeepers between the Wnt/β-catenin-mediated proliferation and differentiation in the intestinal epithelium | [
"van de Grift, Y. B. C.",
"Weiss, T.",
"Castellano, G.",
"Zhong, W.",
"Biechonska, Łucja",
"Hellerstedt, K.",
"Sigvardsson, M.",
"Koch, S.",
"Cantu, C."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.719835v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The Wnt/β-catenin signaling pathway is a conserved cell-to-cell communication mechanism that coordinates a wide spectrum of processes by activating the expression of Wnt target genes 1 . Wnt/β-catenin assum... |
biorxiv | 10.64898/2026.04.22.719677 | 10.64898/2026.04.22.719677 | 1 | Massively parallel reporter assays for CYP3A4 enhancer variants alongside their native promoter | [
"Guttman, Y.",
"Krupkin, B.",
"Ahituv, N."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.719677v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Variation in gene expression is a key driver of phenotypic diversity, disease susceptibility, and variable response to therapy among individuals. A substantial proportion of this variation can be attributed... |
biorxiv | 10.64898/2026.04.22.719628 | 10.64898/2026.04.22.719628 | 2 | Increasing absolute prey community density protects aposematic models and their imperfect Batesian mimics: Evidence from Neotropical Adelpha butterflies | [
"Robinson, A.",
"Camargo-Cely, A.",
"Meyersiek, J.",
"Fetherston, C.",
"Speroff, S.",
"Mishi, M.",
"Sanborn, K.",
"Osipovich, M.",
"Borzymowski, R.",
"Herrmann, J.",
"Finkbeiner, S.",
"Buston, P.",
"Mullen, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.719628v2 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Predator–prey interactions drive the evolution of diverse and complex anti-predator defenses and associated predator counterstrategies ( Ruxton et al., 2018 ; Skelhorn et al., 2016 ; Speed & Turner, 1999 ).... |
biorxiv | 10.64898/2026.04.22.719490 | 10.64898/2026.04.22.719490 | 1 | Brain B Vitamin Status and One-Carbon Metabolism Gene Polymorphisms are Associated with Cognitive Impairment in Alzheimer's and Parkinson's Disease | [
"Kalecky, K.",
"Castaneda-Gill, J.",
"Patel, S.",
"Bottiglieri, T."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.719490v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Alzheimer’s disease (AD) and Parkinson’s disease (PD) are two most prevalent forms of neurodegeneration. While the primary affected brain regions and main symptoms are different, both diseases share several... |
biorxiv | 10.64898/2026.04.22.719367 | 10.64898/2026.04.22.719367 | 2 | Targeting Gi/o-coupled GPCRs to inhibit nociceptors: insights from the serotonin receptor Htr1b and triptans | [
"Peng, J.",
"Sanchez, B. T.",
"Chirila, A. M.",
"Zeng, X.",
"DeLisle, M. M.",
"Qi, L.",
"Xiao, J.",
"Lezgiyeva, K.",
"Low, S. A.",
"Woolf, C. J.",
"Sharma, N.",
"Ginty, D. D."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.719367v2 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Detection of noxious stimuli and the perception of pain are essential for avoiding potential injury. However, pain, defined as “an unpleasant sensory and emotional experience associated with, or resembling ... |
biorxiv | 10.64898/2026.04.22.718469 | 10.64898/2026.04.22.718469 | 1 | Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stress | [
"Gigas, J.",
"Meadow, M. E.",
"Guo, J.",
"Lan, C.",
"Hillpot, E.",
"Martinez, J. C.",
"Tombline, G.",
"Bellomio, P.",
"Welle, K. A.",
"Swovick, K.",
"Hryhorenko, J. R.",
"Ablaeva, J.",
"Ghaemmaghami, S.",
"Seluanov, A.",
"Gorbunova, V."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.718469v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Sirtuins are a family of deacetylases and mono(ADP-ribosyltransferases) that are essential for healthy aging. Broadly, it is thought that sirtuins help fend off many human age-related hallmarks like genomic... |
biorxiv | 10.64898/2026.04.22.718428 | 10.64898/2026.04.22.718428 | 1 | CCZ1 is a modulator of TPC2 activity and melanoma cell migration | [
"Yang, Z.",
"Feldmann, C.",
"Ouologuem, L.",
"Lin, A.",
"Fenske, S.",
"Michalakis, S.",
"Bartel, K.",
"Schaenzler, M.",
"Grimm, C.",
"Chen, C.-C.",
"Wahl-Schott, C.",
"Biel, M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.718428v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Two-pore channels (TPCs) are Ca²⁺- and Na⁺-permeable cation channels that are widely expressed throughout the body and are localized to endolysosomal organelles ( 1 – 4 ). In both mice and humans, two TPC i... |
biorxiv | 10.64898/2026.04.22.716334 | 10.64898/2026.04.22.716334 | 1 | Covalently linked peptides and membrane potential enable CyaA segment translocation | [
"Scilironi, G.",
"Carvalho, N.",
"Frangieh, J.",
"Leger, C.",
"Raoux-Barbot, D.",
"Guijarro, J. I.",
"Ladant, D.",
"Cribier, S.",
"Rodriguez, N.",
"CHENAL, A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.716334v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Whooping cough is a respiratory disease caused by Bordetella pertussis 1 , 2 , which remains particularly dangerous for unvaccinated individuals, especially newborns 3 . The adenylate cyclase (CyaA) toxin i... |
biorxiv | 10.64898/2026.04.21.720041 | 10.64898/2026.04.21.720041 | 1 | Efficient and scalable modelling of cotranscriptional RNA folding with deterministic and iterative RNA structure sampling | [
"Courtney, E.",
"Choi, E.",
"Ward, M.",
"Lucks, J. B."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.720041v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Computational RNA structure sampling is a core component of nearly all RNA ensemble modelling approaches [ 1 ]. Ensemble modelling approaches have become a cornerstone of RNA biology and engineering, used f... |
biorxiv | 10.64898/2026.04.21.720026 | 10.64898/2026.04.21.720026 | 1 | Assessing the socio-economic value of sea turtles to the Maldives' tourism industry in 2022 (post-pandemic) | [
"Gervolino, J.",
"Forster, O.",
"Afeef, I.",
"Rasheed, R. A.",
"Hameed, A.",
"Inan, I.",
"Nashid, D.",
"Petros, C.",
"Lloyd, J. R.",
"Köhnk, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.720026v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The exploitation of sea turtles for subsistence and commercial uses has been well-documented across tropical and subtropical coastal communities for millennia [ 1 – 3 ], and has played a major role in the h... |
biorxiv | 10.64898/2026.04.21.720023 | 10.64898/2026.04.21.720023 | 1 | Genomic dialects: How amino acid properties and the second codon base shape the informational accents of life | [
"Martinez, O.",
"Ochoa-Alejo, N."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.720023v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Codon Usage Bias (CUB) is measured on a numeric scale from zero to one. A value of zero indicates that all synonymous codons for a given amino acid ( aa ) appear with equal frequency within the CDSs of a ge... |
biorxiv | 10.64898/2026.04.21.719997 | 10.64898/2026.04.21.719997 | 1 | C26 and CT26 colorectal cancer models exhibit divergent cachexia phenotypes, intramuscular inflammation, and protein turnover signaling | [
"Lu, X.",
"Tlais, H.",
"Rehman, H.",
"Martens, A. N.",
"Hartz, A. L.",
"Figueiredo, V. C.",
"Markworth, J. F."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719997v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Cancer cachexia is a multifactorial syndrome characterized by progressive loss of body weight, skeletal muscle mass, adipose tissue, and physical function ( 1 ). As the second leading cause of cancer-relate... |
biorxiv | 10.64898/2026.04.21.719991 | 10.64898/2026.04.21.719991 | 1 | Linking neural representations to behavior using generalization | [
"Nunez-Ochoa, M. A.",
"Du, F.",
"Zhong, L.",
"Baptista, S.",
"Michaelos, M.",
"Sohn, A.",
"Baruchin, L.",
"Schröder, S.",
"Stringer, C.",
"Pachitariu, M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719991v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "One of the main goals of systems neuroscience is to understand the neural computations that give rise to animal behaviors. This requires multiple steps, such as identifying the brain regions involved, deter... |
biorxiv | 10.64898/2026.04.21.719973 | 10.64898/2026.04.21.719973 | 1 | Transcriptomic Profiling of Thyroid Eye Disease Orbital Fibroblasts Identifies Sorafenib as a Novel Therapeutic | [
"Yuan, K.",
"Truong, P.",
"Patrick, C.",
"Ushchak, E.",
"Roztocil, E.",
"Feldon, S. E.",
"Woeller, C. F."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719973v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Thyroid eye disease (TED) is a debilitating autoimmune condition characterized by expansion of orbital adipose tissue and fibrosis of the extraocular muscles, leading to proptosis, diplopia, and vision loss... |
biorxiv | 10.64898/2026.04.21.719968 | 10.64898/2026.04.21.719968 | 2 | Fluorescent non-canonical amino acid as a site-specific conformational probe of prion formation | [
"de Alcantara Ferreira, J.",
"Walsh, D. J.",
"Turnbaugh, E.",
"Mills, J. H.",
"Supattapone, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719968v2 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Prions are unconventional infectious agents that cause fatal neurological diseases, including Creutzfeldt-Jakob disease (CJD), bovine spongiform encephalopathy (BSE), and scrapie. Prion diseases can be eith... |
biorxiv | 10.64898/2026.04.21.719960 | 10.64898/2026.04.21.719960 | 1 | Transcriptional regulators predicted to drive macrophage dysregulation during impaired wound healing in diabetic mice | [
"Lukas, B. E.",
"Pang, J.",
"Dai, Y.",
"Koh, T. J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719960v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Chronic wounds associated with diabetes are an escalating problem around the world [ 1 ]. People suffering from diabetes incur a 25% lifetime risk of developing chronic wounds, and associated risk of amputa... |
biorxiv | 10.64898/2026.04.21.719959 | 10.64898/2026.04.21.719959 | 1 | scConcept enables concept-level exploration of single-cell transcriptomic data | [
"Chen, H.",
"Li, Y."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719959v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Gene expression profiling has been widely used to characterizing cells and tissues [ 1 ]. The rapid development of single-cell RNA sequencing (scRNA-seq) technologies has enabled researchers to resolve cell... |
biorxiv | 10.64898/2026.04.21.719951 | 10.64898/2026.04.21.719951 | 2 | Raster photostimulation of large-scale neural populations | [
"LaFosse, P. K.",
"Flickinger, D.",
"Jaindl, G.",
"Drinnenberg, A.",
"Grodem, S.",
"Lensjo, K. K.",
"Ramakrishnan, C.",
"Siverts, L.",
"Zeng, H.",
"Tasic, B.",
"Daigle, T. L.",
"Fyhn, M.",
"Deisseroth, K. L.",
"Stringer, C.",
"Pachitariu, M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719951v2 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Causal perturbations have played a key role in the study of neural computations, starting with lesion studies [ 1 ] and continuing with optogenetic approaches that have enabled precise targeting [ 2 – 7 ]. ... |
biorxiv | 10.64898/2026.04.21.719943 | 10.64898/2026.04.21.719943 | 1 | Genetic compensation in β-actin mutants occurs independently of mutations that destabilize β-actin mRNA | [
"Saini, H.",
"Zhang, J.",
"Dardari, H.",
"Moazed, D."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719943v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Genetic compensation refers to the ability of functionally redundant or paralogous genes to fully or partially compensate for each other’s loss ( 1 , 2 ). When a gene is disrupted, compensation can be achie... |
biorxiv | 10.64898/2026.04.21.719931 | 10.64898/2026.04.21.719931 | 1 | PM2.5 toxin benzopyrene induces life-limiting inflammation and oxidative stress in the airway by up-regulation of TRPC6 and inactivation of β2AR/CFTR signaling | [
"Caohuy, H.",
"Ognoon, M.",
"Chen, T.",
"Dib, T.",
"Pollard, B. S.",
"Fatima, N.",
"Flagg, T.",
"Soni, D. K.",
"Biswas, R.",
"Rittase, W.",
"Lesperance, O. J.",
"Juliano, S.",
"Pollard, H. B."
] | CC0-1.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719931v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Exposure to high atmospheric levels of PM2.5 are associated with increased risks for inflammatory lung diseases, including asthma-like illnesses, c hronic o bstructive p ulmonary d isease (COPD), interstiti... |
biorxiv | 10.64898/2026.04.21.719876 | 10.64898/2026.04.21.719876 | 1 | Probabilistic coupling of cellular and microenvironmental heterogeneity by masked self-supervised learning | [
"Kojima, Y.",
"Tanaka, Y.",
"Hirose, H.",
"Chiwaki, F.",
"Nishimura, K.",
"Hayashi, S.",
"Itahashi, K.",
"Ishikawa, M.",
"Shimamura, T.",
"Mano, H."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719876v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Single-cell transcriptomics has revealed prevalent cellular heterogeneity across diverse biological systems, including disease states[ 1 ]. These data have enabled the reconstruction of developmental lineag... |
biorxiv | 10.64898/2026.04.21.719734 | 10.64898/2026.04.21.719734 | 1 | Verticall: A fast and robust tool for recombination detection in large-scale bacterial genomic datasets | [
"Odih, E. E.",
"Wick, R. R.",
"Holt, K. E."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719734v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Phylogenomics is the field of reconstructing evolutionary histories using whole-genome sequence data [ 1 ]. The resulting phylogenies can then be used for a wide range of analyses, including taxonomic class... |
biorxiv | 10.64898/2026.04.21.719697 | 10.64898/2026.04.21.719697 | 1 | Synovial transcriptional clusters link cartilage degeneration to cell-type-specific gene expression in knee osteoarthritis | [
"Mazzucco, M. R.",
"Mehta, B.",
"Ruiz-Ortiz, J.",
"Hale, C.",
"Omi, F.",
"Singh, P.",
"Yuan, R.",
"Lessard, S.",
"Song, E. K.",
"Zhang, M.",
"Younis, S.",
"Robinson, W. H.",
"Ramirez, D.",
"DiCarlo, E.",
"Wang, W.",
"Carroll, T.",
"Rodriguez, J.",
"Sculco, P.",
"Li, X.",
"Wu, Y... | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719697v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Knee osteoarthritis (OA), characterized by cartilage degeneration, pain, and functional impairment, affects more than 20% of adults aged 40 years and older worldwide[ 1 ]. The combination of high population... |
biorxiv | 10.64898/2026.04.21.719679 | 10.64898/2026.04.21.719679 | 1 | A human specific CCG repeat in the RBFOX1 promoter is implicated in speech and autism | [
"Lee, C.",
"Davenport, M. H.",
"Jarvis, E. D."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719679v1 | 2026-04-24T00:00:00 | [
{
"type": "para",
"text": "Understanding the causal variants and molecular mechanisms underlying human-specific traits, such as language, is a central challenge in the new era of complete genome sequences. In the case of language, this trait is associated with specialized up- or down-regulation of 100s to 1... |
biorxiv | 10.64898/2026.04.21.719530 | 10.64898/2026.04.21.719530 | 1 | Targeted medial prefrontal cortex stimulation prevents incubation of cocaine craving and restores functional connectivity | [
"Lu, H.",
"Hoffman, S.",
"Duan, Y.",
"Ma, Z.",
"Nguyen, H.",
"Carney, A. F.",
"Scott, T.",
"Varlas, O.",
"Haque, M. M.",
"Stein, E. A.",
"Xi, Z.-X.",
"Shaham, Y.",
"Yang, Y."
] | CC0-1.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719530v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Cocaine use remains a major public health concern, impacting an estimated 22 million people globally ( 1 ). In the United States, deaths from cocaine-related overdoses have increased more than fourfold over... |
biorxiv | 10.64898/2026.04.20.719540 | 10.64898/2026.04.20.719540 | 1 | Integrating AI and molecular modeling for structural prediction of a closed state of the hERG channel | [
"Upex, C.",
"Osborne, T.",
"Biglino, G.",
"Hancox, J.",
"Corey, R. A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719540v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The voltage-sensitive potassium (K + ) channel Kv11.1, also known as hERG1 (hereafter hERG), plays a critical role in the repolarisation phase of the cardiac action potential by mediating the rapid componen... |
biorxiv | 10.64898/2026.04.18.719399 | 10.64898/2026.04.18.719399 | 3 | Failure to classically condition planarian flatworms | [
"Kelso, Z. S.",
"Snyder, M. C.",
"Gershman, S. J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.18.719399v3 | 2026-04-20T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Evolutionary and comparative neuroscience suggest that planarian nervous systems represent the most basal, Urbilaterian-like brains of any contemporary organism [ 1 – 4 ]. Consequently, planarians offer a w... |
biorxiv | 10.64898/2026.04.17.718988 | 10.64898/2026.04.17.718988 | 2 | Ancestra: A lineage-explicit simulator for benchmarking B-cell receptor repertoire and lineage inference methods | [
"Hassanzadeh, R.",
"Abdollahi, N.",
"Kossida, S.",
"Giudicelli, V.",
"Eslahchi, C."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.17.718988v2 | 2026-04-21T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Advances in high-throughput immune repertoire sequencing (AIRR-seq) have enabled detailed characterization of B-cell receptor (BCR) repertoires across diverse biological and clinical contexts, including vac... |
biorxiv | 10.64898/2026.04.16.718586 | 10.64898/2026.04.16.718586 | 2 | Metatranscriptome data support the existence of two distinct morphotypes in a single parmalean species in natural environments | [
"Sasaki, H.",
"Endo, H.",
"Pelletier, E.",
"Yoshikawa, S.",
"Kuwata, A.",
"Ogata, H."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.16.718586v2 | 2026-04-17T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Diatoms are one of the most ecologically successful groups of phytoplankton, accounting for approximately 20% of primary production in modern oceans ( Armbrust, 2009 ). However, the drivers of their ecologi... |
biorxiv | 10.64898/2026.04.13.718277 | 10.64898/2026.04.13.718277 | 2 | NPP-21/TPR is required for developmental control of spindle checkpoint strength in C. elegans | [
"Gallagher, N.",
"Brown, S.",
"Duprat, V.",
"Köhler, S.",
"Dernburg, A. F.",
"Bhalla, N."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.13.718277v2 | 2026-04-15T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The spindle checkpoint is a cell cycle surveillance mechanism that ensures that chromosomes are attached to the mitotic or meiotic spindle to guarantee accurate chromosome segregation and prevent aneuploidy... |
biorxiv | 10.64898/2026.04.05.716628 | 10.64898/2026.04.05.716628 | 2 | Single-section multiplexed imaging enables comprehensive lung cancer diagnosis | [
"Ben-uri, R.",
"Keidar Haran, T.",
"Bussi, Y.",
"Vainer, G.",
"Arnon, J.",
"Pillar, N.",
"Bahlai, S.",
"Sourikh, H.",
"Fuchs, I.",
"Elhanani, O.",
"Neuman, T.",
"Pikarsky, E.",
"Keren, L."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.05.716628v2 | 2026-04-08T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Lung cancer is the leading cause of cancer-related mortality worldwide, with approximately 2.5 million new cases and over 1.8 million deaths reported annually 1 . However, therapeutic advances over the past... |
biorxiv | 10.64898/2026.03.27.714601 | 10.64898/2026.03.27.714601 | 2 | The limits of scaling in aggregation-driven patterning of cell collectives | [
"Zhao, M. L.",
"Rombouts, J.",
"Stokkermans, A.",
"Erzberger, A.",
"Aulehla, A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.03.27.714601v2 | 2026-03-30T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "How cell fate patterns change with the size of multicellular systems is a fundamental question. Developing embryos exhibit the remarkable ability to scale cell fate patterns with overall system size [ 1 – 5... |
biorxiv | 10.64898/2026.03.26.714426 | 10.64898/2026.03.26.714426 | 2 | Distinct effects of sensory and genetic risk factors for psychosis on auditory cortical temporal acuity in a mouse model of 22q11.2 Deletion Syndrome | [
"Lu, C.",
"Linden, J. F."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.03.26.714426v2 | 2026-03-26T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Clinical studies have shown that psychosis impairs auditory processing, including frequency discrimination, spatial localization, deviant detection, and prepulse inhibition ( 1 ). In addition, patients with... |
biorxiv | 10.64898/2026.03.19.712999 | 10.64898/2026.03.19.712999 | 2 | Chromatin priming and co-factor availability shape lineage response to the neuronal pioneer factor ASCL1 in pluripotency | [
"Lundie-Brown, J.",
"Drummond, R.",
"Ng-Blichfeldt, J.-P.",
"Azzarelli, R.",
"Philpott, A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.03.19.712999v2 | 2026-03-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Development requires precise control over the generation of diverse cell types. Achieving the correct spatial and temporal coordination of growth, differentiation, and morphogenesis requires cells to regula... |
biorxiv | 10.64898/2026.03.18.712438 | 10.64898/2026.03.18.712438 | 2 | Maintenance cost of photosynthesis sets key ecological constraints on zooxanthellate corals | [
"Gomez-Campo, K.",
"Martinez-Rugerio, M. I.",
"Gomez Reali, M. A.",
"Gonzalez-Pech, R. A.",
"Santiago-Martinez, M. G.",
"Turnham, K. E.",
"LaJeunesse, T. C.",
"Baums, I. B.",
"Enriquez, S.",
"Iglesias-Prieto, R."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.03.18.712438v2 | 2026-03-20T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Light supplies the energy that sustains coral reef ecosystems, but its role in shaping coral distribution cannot be explained by light availability alone. Variation in light quantity and spectral compositio... |
biorxiv | 10.64898/2026.02.25.707869 | 10.64898/2026.02.25.707869 | 2 | Gene-First Identity Construction for Robust Cell Identification in Single-Cell Transcriptomics | [
"Yang, L.",
"Huang, Z.",
"Cai, J.",
"Xin, H."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.02.25.707869v2 | 2026-02-26T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "In the era of large-scale single-cell atlases, accurate and stable cell-type definition has become a central challenge in computational biology[ 1 , 2 ]. Projects such as the Human Cell Atlas[ 3 ], Tabula S... |
biorxiv | 10.64898/2026.01.22.701099 | 10.64898/2026.01.22.701099 | 3 | MetaTree: an interactive web platform for aligned hierarchical data visualization and multi-group comparison | [
"Wu, Q.",
"Zhang, A.",
"Ning, Z.",
"Figeys, D."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.01.22.701099v3 | 2026-01-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Background"
},
{
"type": "para",
"text": "Many biological datasets, including taxonomic hierarchies and functional classification systems [ 1 - 3 ], are organized across multiple levels. In microbiome workflows such as 16S rRNA sequencing [ 4 ], shot... |
biorxiv | 10.64898/2026.01.21.700902 | 10.64898/2026.01.21.700902 | 2 | Lupus Immune Complexes Drive Distinct Pro-Inflammatory Monocyte and Macrophage Populations Independent of Type I Interferon | [
"Osmani, L.",
"Shin, M.",
"Lee, S. J.",
"Cai, H.",
"Seong, W. J.",
"Kim, H.",
"Yoo, J.",
"Kim, M.",
"Bracamonte, W.",
"Felix, M.",
"Ahn, J. G.",
"Park, H.-J.",
"Shin, J. J.",
"Unlu, S.",
"Par-Young, J.",
"Doherty, E.",
"Chen, J.",
"Dong, M. X.",
"Koumpouras, F.",
"Gomez, J. L."... | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.01.21.700902v2 | 2026-01-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Systemic lupus erythematosus (SLE or lupus) is a multi-systemic autoimmune-mediated inflammatory disease of unknown etiology involving multiple organs. The pathologic features of SLE are thought to involve ... |
biorxiv | 10.1101/2025.11.28.691195 | 10.1101/2025.11.28.691195 | 3 | Adapting Co-Folding Models for Structure-Based Protein-Protein Docking Through Flow Matching | [
"Xu, D.",
"Chu, L.-S.",
"Gray, J. J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.11.28.691195v3 | 2025-12-01T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Protein-protein interactions mediate critical processes in all forms of life, and the accurate prediction of the three-dimensional details of such interactions can provide significant insights into many bio... |
biorxiv | 10.1101/2025.11.13.688255 | 10.1101/2025.11.13.688255 | 3 | Regional adaptation to mosquito vectors shapes Plasmodium falciparum populations | [
"Loesbanluechai, D.",
"Sollelis, L.",
"Armstrong, M.",
"Menezes, I.",
"Cox, A.",
"Divala, L. B. T.",
"Lawson, A.",
"Pradhan, S.",
"Ubiaru, P. C.",
"Pallikara, A.",
"Armstrong, D.",
"Parker, G.",
"Lee, C.",
"Pearson, R. D.",
"Stokes, B. H.",
"Ranford-Cartwright, L. C.",
"Marti, M.",
... | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.11.13.688255v3 | 2025-11-13T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Malaria remains one of the world’s most devastating infectious diseases, causing more than 500,000 deaths each year [ 1 ]. The disease is caused by Plasmodium parasites transmitted through the bites of Anop... |
biorxiv | 10.1101/2025.10.14.682310 | 10.1101/2025.10.14.682310 | 4 | Quantitative genetics of lifetime growth curves in a lizard | [
"Aragon, A.",
"Rutschmann, A.",
"Richard, M.",
"Bestion, E.",
"Pellerin, F.",
"Winandy, L.",
"San-Jose, L. M.",
"Di Gesu, L.",
"Darnet, E.",
"Cribellier, J.",
"Massot, M.",
"Clobert, J.",
"Cote, J.",
"de Villemereuil, P."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.10.14.682310v4 | 2025-10-15T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The body size of individuals impacts a large variety of their biology, from their ecology to their physiology ( LaBarbera, 1989 ). One particular aspect of body size, for most species, is that it is general... |
biorxiv | 10.1101/2025.09.24.678246 | 10.1101/2025.09.24.678246 | 2 | Validating Conditionally Essential Targets: Discovery of the First Orally Effective Biotin Inhibitor against MycobacteriumTuberculosis | [
"Liu, Q.",
"Wallach, J. B.",
"Jayasinghe, Y. P.",
"Sullivan, M. R.",
"Proietto, J.",
"Rodriguez, S.",
"Vo, S.",
"Boshoff, H. I. M.",
"Jia, Z.",
"Ostrer, L.",
"Mehdiratta, K.",
"Shi, R.",
"Dartois, V.",
"Baughn, A. D.",
"Rubin, E. J.",
"Ronning, D. R.",
"Zimmerman, M. D.",
"Schnappi... | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.09.24.678246v2 | 2025-09-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Antimicrobial resistance (AMR) is a rapidly intensifying global health crisis, fueled by overuse of antibiotics, incomplete treatment, environmental contamination, and inadequate sanitation 1 . The 2024 WHO... |
biorxiv | 10.1101/2025.07.02.662782 | 10.1101/2025.07.02.662782 | 3 | Tracking West Nile virus dynamics using viral loads from trapped mosquitoes | [
"Alahakoon, P.",
"Marchinton, I.",
"Koch, R.",
"Fauver, J. R.",
"Hay, J. A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.07.02.662782v3 | 2025-07-05T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "West Nile disease is a vector-borne disease caused by West Nile virus (WNV) infection [ 1 ]. It is maintained in an enzootic cycle between mosquitoes and birds [ 1 , 2 ], with humans as incidental hosts [ 3... |
biorxiv | 10.1101/2024.07.15.603538 | 10.1101/2024.07.15.603538 | 3 | Modeling causal signal propagation in multi-omic factor space with COSMOS | [
"Dugourd, A.",
"Lafrenz, P.",
"Mananes, D.",
"Paton, V.",
"Fallegger, R.",
"Bai, Y.",
"Kroger, A.-C.",
"Turei, D.",
"Li, Y.",
"Trogdon, M.",
"Nager, D.",
"Deng, S.",
"Shen, C.",
"Lapek, J. D.",
"Shtylla, B.",
"Saez-Rodriguez, J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2024.07.15.603538v3 | 2024-07-17T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Many diseases are the result of complex deregulations of several interconnected biological mechanisms that span over cell-cell communication mediated by ligands and receptors, intracellular signaling, gene ... |
biorxiv | 10.64898/2026.04.23.720446 | 10.64898/2026.04.23.720446 | 1 | Linked origins but distinct roles for extreme length and sequence variation at a tandem repeat in CACNA1C | [
"Song, J.",
"Zhao, V.",
"Grant, R. L.",
"Kingsley, D. M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720446v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Tandem repeats have been implicated in a wide range of diseases, including Huntington disease, spinocerebellar ataxia, and epilepsy, and likely contribute to undetected variation and missing heritability fo... |
biorxiv | 10.64898/2026.04.23.720375 | 10.64898/2026.04.23.720375 | 1 | Universal Geometry of Compositional Construction in Prefrontal Cortex | [
"Manakov, M.",
"Proskurin, M.",
"Wang, H.",
"Kuleshova, E.",
"Lustig, A.",
"Behnam, R.",
"Druckmann, S.",
"Tervo, D. G. R.",
"Koay, S. A.",
"Karpova, A. Y."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720375v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The ability to systematically construct new, complex behaviors or ideas from simpler parts is a hallmark of intelligence. A longstanding proposal is that composition provides a simple and general mechanism ... |
biorxiv | 10.64898/2026.04.23.720354 | 10.64898/2026.04.23.720354 | 1 | A metagenomic framework for rapid Listeria monocytogenes surveillance in food production environments | [
"Muchaamba, F.",
"Reska, T.",
"Biggel, M.",
"Locken, K. M.",
"Weilguny, L.",
"Corti, S.",
"Kelbert, L.",
"Roger, S.",
"Urban, L."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720354v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Listeria monocytogenes remains one of the most consequential foodborne pathogens, responsible for severe invasive disease and disproportionately high mortality (European Food Safety Authority (EFSA) and Eur... |
biorxiv | 10.64898/2026.04.23.720330 | 10.64898/2026.04.23.720330 | 2 | Visual cortical dynamics supporting predictable attentional capture | [
"Groot, J. J.",
"Schall, J. D.",
"Westerberg, J. A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720330v2 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Our senses continuously sample a broad range of rich sensory information. Yet, the brain’s limited processing capacity prevents it from scrutinizing every input. As such, efficient interaction with the envi... |
biorxiv | 10.64898/2026.04.23.720320 | 10.64898/2026.04.23.720320 | 1 | Dynamic construction of subjective time through statistical learning of event structure | [
"Zeng, Q.",
"Trübutschek, D.",
"Turk-Browne, N. B.",
"Melloni, L."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720320v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "When listening to a language we do not understand, speech can feel strikingly fast. Once that same language becomes familiar, the very same acoustic input appears to slow down. Crucially, this shift occurs ... |
biorxiv | 10.64898/2026.04.23.720313 | 10.64898/2026.04.23.720313 | 1 | Brain2VLM: Hierarchical Alignment Between Cortical Representations and Vision-Language Latent Spaces | [
"Pritam, N. A. A.",
"O, J. S.",
"Jain, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720313v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Understanding how the human brain represents and reconstructs visual experience remains a central challenge in NeuroAI. Brain decoding aims to recover sensory stimuli from non-invasive brain recordings such... |
biorxiv | 10.64898/2026.04.23.720151 | 10.64898/2026.04.23.720151 | 1 | A liquid handling platform for standardised quantification of cell-free enzymatic activity encoded by antimicrobial resistance genes | [
"Bergum, M.",
"Martin, B.",
"Sutton, J. M.",
"Moore, S. J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720151v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Antimicrobial resistance (AMR) is a global concern to human health, contributing to millions of deaths each year. 1 Bacteria can acquire novel AMR through intrinsic genetic changes, including chromosomal mu... |
biorxiv | 10.64898/2026.04.22.720271 | 10.64898/2026.04.22.720271 | 1 | Revisiting phage-host inference from metagenome-assembled genomes reveals the need for scaffold-level validation | [
"Yuan, L.",
"Anantharaman, K.",
"Ma, B.",
"Camargo, A. P.",
"Chen, L."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720271v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Viruses are the most abundant biological entities on Earth and have been recognized as integral components of ecosystems across the planet 1 – 3 . Viruses that exclusively infect bacteria are known as bacte... |
biorxiv | 10.64898/2026.04.22.720243 | 10.64898/2026.04.22.720243 | 1 | Analysis of Flurothyl-induced Seizures and Epileptogenesis in Mice with Targeted Deletions of Exons 3 and 4 in Dock7 | [
"Ferland, R. J.",
"Lizotte, T.",
"Becker, K. A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720243v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Epilepsy affects approximately 1.2% of the U.S. population, making it one of the most prevalent neurological conditions ( 1 ). Current anti-epileptic treatments focus on suppressing seizures, but do not tar... |
biorxiv | 10.64898/2026.04.22.720242 | 10.64898/2026.04.22.720242 | 1 | Genome quality variation across Scyphozoa and the comparative distribution of retinoid- and AhR-related gene families. | [
"Park, Y.-J.",
"Lee, N.",
"JO, Y.",
"Yum, S.",
"Kwon, K. K."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720242v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Scyphozoa exhibit a complex life cycle that alternates between sessile and pelagic stages, including polyp, strobila, ephyra, and medusa stages [ 1 ]. A key developmental transition in this cycle is strobil... |
biorxiv | 10.64898/2026.04.22.720190 | 10.64898/2026.04.22.720190 | 1 | Two mammalian-like cysteine dioxygenases and a sulfite exporter play important roles in sulfur homeostasis and virulence of a human pathogen | [
"Saha, A.",
"Petrackova, D.",
"Holubova, J.",
"Vecerek, B."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720190v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Sulfur is one of the essential nutrients required by cells for growth. In most cells, sulfur is incorporated into sulfur-containing amino acids cysteine and methionine, cofactors such as thiamine and biotin... |
biorxiv | 10.64898/2026.04.22.720187 | 10.64898/2026.04.22.720187 | 2 | Hierarchical Breakdown of RNA Structure Prediction in CASP16: From Reliable Local Features to Speculative Multimer Assembly | [
"Nithin, C.",
"Pilla, S. P.",
"Kmiecik, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720187v2 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The functional diversity of RNA molecules, extending from their canonical roles in the central dogma to complex regulatory and catalytic activities, is intimately linked to their ability to fold into specif... |
biorxiv | 10.64898/2026.04.22.720137 | 10.64898/2026.04.22.720137 | 1 | Boreal and subarctic freshwaters harbour a diversity of jumbophages | [
"Niemi, M.",
"Karneyeva, K.",
"Sundberg, L.-R.",
"Oksanen, H. M.",
"Laanto, E."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720137v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The boreal biome, the world’s largest terrestrial biome, contains extensive networks of lakes, rivers, and wetlands that support diverse microbial communities adapted to cold, nutrient-poor, and humic-rich ... |
biorxiv | 10.64898/2026.04.22.720114 | 10.64898/2026.04.22.720114 | 1 | CurT dosage quantitatively affects thylakoid structure and PSII performance in Synechocystis sp. PCC 6803 | [
"Ostermeier, M.",
"Pohland, A.-C.",
"Dann, M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720114v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Cyanobacteria are one of the most ancient and taxonomically diverse bacterial clades defined by their capacity for oxygenic photosynthesis ( Garcia-Pichel et al., 2020 ), relying on the tandem operation of ... |
biorxiv | 10.64898/2026.04.22.720112 | 10.64898/2026.04.22.720112 | 1 | Proximity proteomics reveals a role for IFI16 during human coronavirus infection | [
"Languon, S.",
"Bailey, I.",
"Sorensen, M.",
"Miller, Z. D.",
"Sha, J.",
"Dearborn, J.",
"Dowell, W.",
"Kirch, T.",
"Wohlschlegel, J.",
"MAJUMDAR, D."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720112v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Coronaviruses are enveloped, positive-sense single-stranded RNA viruses that are classified under the family Coronaviridae which consist of four genera Alpha-, Beta-, Gamma- , and Deltacoronavirus . While A... |
biorxiv | 10.64898/2026.04.22.718605 | 10.64898/2026.04.22.718605 | 1 | Ocean acidification alters hypoxia sensitivity and oxyregulation in reef-building corals | [
"van der Zande, R. M.",
"Johnson, K. W.",
"Littke, S.",
"Schoepf, V."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.718605v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Ocean deoxygenation and the emergence of dead zones are becoming increasingly prevalent and damaging to coastal marine ecosystems globally 1 – 3 . Its effects likely already surpass those of ocean warming a... |
biorxiv | 10.64898/2026.04.21.720022 | 10.64898/2026.04.21.720022 | 1 | Altitude-mediated niche partitioning between Dacus bivittatus and Dacus punctatifrons along an elevational transect in the Uluguru Mountains, Tanzania | [
"Mwatawala, M. W.",
"Ruboha, J. O.",
"Bakengesa, J.",
"Zinga, M. K.",
"De Meyer, M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.720022v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Fruit flies (Diptera: Tephritidae) are among the most important pests of horticultural crops worldwide because larval feeding within fruits reduces yield and market quality and may trigger quarantine and tr... |
biorxiv | 10.64898/2026.04.21.720009 | 10.64898/2026.04.21.720009 | 1 | Aligned recordings of neural spiking activity and licking behavior in thirsty mice | [
"Xu, Z.",
"Hong, B.",
"Li, L.",
"Xie, T.",
"Chen, Z.",
"Yao, H.",
"Zhang, T."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.720009v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Background and Summary"
},
{
"type": "para",
"text": "Mice have gained increasing prominence in neuroscience and physiology research due to their well-defined genetics [ 1 ], controllable behaviors [ 2 ] and mature experimental toolkits [ 3 ]. For ex... |
biorxiv | 10.64898/2026.04.21.720000 | 10.64898/2026.04.21.720000 | 2 | Entrenchment of germline amino-acid differences in antibody affinity maturation | [
"Harel, N.",
"Sung, K.",
"Dumm, W.",
"Johnson, M. M.",
"Rich, D.",
"Fukuyama, J.",
"Haddox, H. K.",
"Matsen, F. A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.720000v2 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Amino acid differences between homologous proteins can become entrenched: maintained by epistatic constraints such that each homolog disfavors substitutions toward the other’s state [ 1 ]. Previous studies ... |
biorxiv | 10.64898/2026.04.21.719942 | 10.64898/2026.04.21.719942 | 1 | A modelling technique unifying four paradigms of metacommunity theory | [
"Shahin, S.",
"G. Rossberg, A.",
"D. O'Sullivan, J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719942v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Metacommunity theory provides a framework for understanding how species distributions arise from the interplay of local population dynamics and dispersal between spatially discrete habitat patches ( Leibold... |
biorxiv | 10.64898/2026.04.21.719933 | 10.64898/2026.04.21.719933 | 1 | Contamination of Engram Coactivity Networks During Forgetting | [
"An, L.",
"Yang, M.",
"Wang, H."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719933v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Forgetting is an essential activity-dependent process that underpins the efficiency of the learning and memory system ( 1 - 3 ). In a dynamic environment where not all information is equally relevant, the a... |
biorxiv | 10.64898/2026.04.21.719921 | 10.64898/2026.04.21.719921 | 1 | Reflectance spectra capture temporal variation in functional traits and leaf phenology | [
"Nichodemus, C. O.",
"Meireles, J. E."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719921v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Plant functional traits — measurable characteristics that underlie how plants interact with and respond to their environment ( Violle et al ., 2007 ) — provide an integrative framework for understanding fit... |
biorxiv | 10.64898/2026.04.21.719900 | 10.64898/2026.04.21.719900 | 1 | Growth costs of suboptimal protein allocation in nonlinear models of growing cells | [
"Szeliova, D.",
"Liebermeister, W.",
"Lercher, M.",
"Dourado, H."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719900v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Proteins play a central role in determining microbial growth, in particular by composing the catalysts of biochemical reactions such as the transporters exchanging resources with the environment, internal e... |
biorxiv | 10.64898/2026.04.21.719899 | 10.64898/2026.04.21.719899 | 2 | Pharmacologic AMPK Activation Extends Lifespan in C. elegans and Improves Aspects of Healthspan in Mice | [
"Altintas, O.",
"Knufinke, M.",
"Mann, C. G.",
"Langston, P. K.",
"Rabinowitz, J. D.",
"Murphy, C. T.",
"Ewald, C. Y.",
"Mitchell, S. J.",
"MacArthur, M. R."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719899v2 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Metabolic dysfunction is a key feature of aging and includes impaired nutrient sensing, altered mitochondrial function and loss of normal circadian rhythmicity in macronutrient utilization ( López-Otín et a... |
biorxiv | 10.64898/2026.04.21.719898 | 10.64898/2026.04.21.719898 | 1 | Cryo-EM structure of MutL-activated MutH | [
"Ulloa, E. A.",
"Lamers, M. H."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719898v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "The faithful replication of genetic information requires the correction of mispaired bases that occur during DNA synthesis. DNA mismatch repair (MMR) is a post-replicative pathway that recognises and correc... |
biorxiv | 10.64898/2026.04.21.719882 | 10.64898/2026.04.21.719882 | 1 | Machine Learning Approach for Enumeration of Circulating Cells with Diffuse in vivo Flow Cytometry | [
"Emamifar, M.",
"Lee, J.",
"Pace, J. S.",
"Bellini, C.",
"Niedre, M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719882v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Metastasis accounts for the majority of cancer-related deaths, and one of the main pathways of spread is via the peripheral blood (PB). As such, circulating tumor cells (CTCs) may serve as an important indi... |
biorxiv | 10.64898/2026.04.21.719881 | 10.64898/2026.04.21.719881 | 1 | Structural basis of substrate recognition and conformational gating in the bacteriophage M15 metalloendopeptidase LysPH | [
"Pahwa, D.",
"Pandey, S.",
"Pandey, N.",
"Kumar, K. A.",
"Choudhary, P.",
"Unni, A.",
"Choudhary, I.",
"Ashar, M.",
"Omar, B. J.",
"Uniyal, M.",
"Rao, S.",
"Sharma, A. K.",
"Tomar, S.",
"KUMAR, P."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719881v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The rise of multidrug-resistant bacteria is a major threat to global health, severely limiting the effectiveness of current antibiotic treatments. The ESKAPE pathogens include Pseudomonas aeruginosa, Acinet... |
biorxiv | 10.64898/2026.04.21.719877 | 10.64898/2026.04.21.719877 | 1 | Generation of Pathway Signatures by Combining Normal Modes with Weighted Ensemble Simulations | [
"Bogetti, A. T.",
"Banerjee, A.",
"Dill, K.",
"Bahar, I."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719877v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "As is often the case, there is no “absolute best” method for simulating biomolecules like proteins. Often, there is a sharp tradeoff between model detail and the time cost of the simulated data. Take for in... |
biorxiv | 10.64898/2026.04.21.719848 | 10.64898/2026.04.21.719848 | 1 | Interleaved multi-magnification cryo-electron tomography bridges cellular and structural biology | [
"Watson, H.",
"Garcia-Giner, V.",
"Eisenstein, F.",
"Grange, M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719848v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "A holistic understanding of the molecular organisation within a biological system requires integration of structural information across multiple spatial scales, from atomic-level molecular interactions to t... |
biorxiv | 10.64898/2026.04.21.719847 | 10.64898/2026.04.21.719847 | 1 | Attracting Cavities 3.0: Faster and More Versatile Molecular Docking for the SwissDock Webserver | [
"Roehrig, U. F.",
"Mathieu-Bugnon, M.",
"Zoete, V."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719847v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Molecular docking is a computational approach for predicting the most probable binding mode of a small molecule to a macromolecular target, most commonly a protein, but possibly also a DNA or RNA. Docking a... |
biorxiv | 10.64898/2026.04.21.719842 | 10.64898/2026.04.21.719842 | 1 | Nuclear Pct1 couples phosphatidylcholine synthesis with membrane biogenesis | [
"Lysyganicz, P. K.",
"Toprakcioglu, Z.",
"Guo, J.",
"Barbosa, A. D.",
"Jenkins, B. J.",
"Lim, K.",
"Koulman, A.",
"Knowles, T. P. J.",
"Dymond, M. K.",
"Savage, D. B.",
"Siniossoglou, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719842v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Biological membranes are an essential component of life. Membranes define the boundaries of cells; compartmentalize biochemical machineries within organelles; and provide a scaffold for complex reactions to... |
biorxiv | 10.64898/2026.04.21.719831 | 10.64898/2026.04.21.719831 | 1 | Species-specific responses of helminths to temperature and moisture: long-term and multi-scale analyses in a free-living rodent | [
"Olarewaju, A. E.",
"Zawadzka-Pawlewska, U.",
"Ayansola, V. I.",
"Dunn, A.",
"Rybinska, A.",
"Bajer, A.",
"Behnke, J.",
"Alsarraf, M.",
"Dwuznik-Szarek, D.",
"Tołkacz, K.",
"Grzybek, M.",
"Behnke-Borowczyk, J.",
"Kloch, A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719831v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Parasite communities exhibit significant variation in their distribution and abundance across temporal and spatial scales, shaped by complex interactions among host-related, ecological, and environmental fa... |
biorxiv | 10.64898/2026.04.21.719819 | 10.64898/2026.04.21.719819 | 1 | Environment-aware genomic prediction enhances the transferability of polygenic resistance to ash dieback in Fraxinus excelsior | [
"Meger, J.",
"Ulaszewski, B.",
"Burczyk, J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719819v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Tree diseases are increasingly recognized as major drivers of biodiversity loss, reduced productivity, and ecosystem disruption in forests worldwide ( Boyd et al., 2013 ; Fisher et al., 2012 ; Santini et al... |
biorxiv | 10.64898/2026.04.21.719818 | 10.64898/2026.04.21.719818 | 1 | Pupil and Neural Dynamics Reveal Belief-Dependent Decision Making Under Ambiguity | [
"Qin, Y.",
"Rungratsameetaweemana, N.",
"Lauharatanahirun, N.",
"Sajda, P."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719818v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Humans make decisions in situations where outcomes are unknown, and the probabilities of benefit and harm are incomplete or unknown. Such decisions shape behavior across many domains, including financial in... |
biorxiv | 10.64898/2026.04.21.719817 | 10.64898/2026.04.21.719817 | 1 | Fine-scale behavioural dynamics separates adaptive sickness behaviour from injury and infection pathology | [
"V Cano, A.",
"Newman, D.",
"Monteith, K. M.",
"Dakos, V.",
"Vale, P. F."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719817v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Animals commonly exhibit coordinated changes in behaviour during infection, including reduced locomotion, altered feeding, increased sleep or rest, and changes in social interaction 1 – 4 . Collectively ter... |
biorxiv | 10.64898/2026.04.21.719816 | 10.64898/2026.04.21.719816 | 1 | Back to BERT in 2026: ModernGENA as a Strong, Efficient Baseline for DNA Foundation Models | [
"Aspidova, A.",
"Kuratov, Y.",
"Shadskiy, A.",
"Burtsev, M.",
"Fishman, V."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719816v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "I ntroduction"
},
{
"type": "para",
"text": "DNA encodes a vast amount of biologically meaningful information, including regulatory logic, evolutionary constraints, and functional signals, that we are still far from fully decoding. Deep learning offe... |
biorxiv | 10.64898/2026.04.21.719811 | 10.64898/2026.04.21.719811 | 1 | An auxiliary protein tunes reductase activity in alkaloid biosynthesis | [
"Carr, S. C.",
"Wu, S.",
"Gase, K.",
"Nakamura, Y.",
"Kamileen, M. O.",
"Kunert, M.",
"Heinicke, s.",
"Kang, M.",
"Grabe, V.",
"Caputi, L.",
"O'Connor, S. E."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719811v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Monoterpene indole alkaloids are an important class of natural products produced by plant species in the order Gentianales, with over 3000 structurally distinct molecules reported ( 1 ). The medicinal value... |
biorxiv | 10.64898/2026.04.21.719810 | 10.64898/2026.04.21.719810 | 1 | Towards Scaling-Up Three-Dimensional Habitat Structural Measurements with Multi-Sensor Remote Sensing | [
"Suter, S.",
"Ah-Peng, C.",
"Kabache, S.",
"Seidel, D.",
"Strasberg, D.",
"Zemp, D. C."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719810v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Conservation efforts rely on standardised methods to monitor biodiversity changes across spatial scales. The Essential Biodiversity Variables (EBVs), provide a globally applicable framework for monitoring k... |
biorxiv | 10.64898/2026.04.21.719804 | 10.64898/2026.04.21.719804 | 1 | Centromeric variation is shared across ploidy barriers in Alnus glutinosa agg. | [
"Gerchen, J. F.",
"Mandak, B.",
"Melnyk, M.",
"Kolar, F."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719804v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Polyploidy, the presence of multiple genome copies as a result of whole-genome duplication, is common in plants ( Otto & Whitton 2000 ) and genomic analyses showed that polyploidy occurred in several common... |
biorxiv | 10.64898/2026.04.21.719799 | 10.64898/2026.04.21.719799 | 1 | Predicting Valley Fever Outbreaks: Novel Mechanistic Models Incorporating Climate and Ecological Interactions | [
"Reckell, T.",
"Sterner, B.",
"Engelthaler, D.",
"Jevtic, P."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719799v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Coccidioidomycosis (Valley fever) is an environmentally driven fungal disease transmitted via inhalation of airborne Coccidioides spores, whose incidence is tightly coupled to climatic, ecological, and soil... |
biorxiv | 10.64898/2026.04.21.719798 | 10.64898/2026.04.21.719798 | 1 | Focal inbreeding and clonal transmission of Plasmodium vivax in pre-elimination Vietnam | [
"Ngwana-Joseph, G.",
"Nguyen Thi Huong, B.",
"Nguyen Thi Hong, N.",
"Phelan, J. E.",
"Campino, S.",
"Nguyen Quang, T.",
"Clark, T. G."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719798v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Vietnam, along with countries in and around the Greater Mekong Subregion (GMS), is actively pursuing elimination of Plasmodium vivax (P. vivax) , the leading cause of malaria in the country, by 2030[ 1 ]. B... |
biorxiv | 10.64898/2026.04.21.719794 | 10.64898/2026.04.21.719794 | 1 | Dynamic Workforce Modulation and Foraging Efficiency in Eusocial Insect Colonies | [
"Campos, D.",
"Cristin, J.",
"Fernandez-Lopez, P.",
"Bartumeus, F."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719794v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Eusociality provides biological species with a fundamentally expanded repertoire of adaptive strategies, offering sub-stantial advantages in ecological and evolutionary contexts. This view is reinforced by ... |
biorxiv | 10.64898/2026.04.21.719793 | 10.64898/2026.04.21.719793 | 1 | Natural Killer Cell Granule Protein (NKG7) promotes the development of vaccine-induced anti-fungal Th1 cells | [
"Wuthrich, M.",
"Taira, C. L.",
"dos Santos Dias, L.",
"He, X.",
"Lichtenberger, S.",
"Klein, B."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719793v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "The role of IFNγ in antifungal resistance has been studied extensively. While IFNγ produced by CD4 + T cells promotes resistance to infection, too much IFNγ results in immunopathology and progressive infect... |
biorxiv | 10.64898/2026.04.21.719673 | 10.64898/2026.04.21.719673 | 1 | Loss of phosphorylation sites required for β-arrestin recruitment in the calcium-sensing receptor cytoplasmic region may contribute to hypocalcemia | [
"Wyatt, R. A.",
"Massalha, H.",
"Gorvin, C. M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719673v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The class C GPCR, CaSR, is essential for maintaining calcium homeostasis by regulating parathyroid hormone release and urinary calcium excretion ( 1 ). Receptor activation elicits signaling predominantly by... |
biorxiv | 10.64898/2026.04.21.719669 | 10.64898/2026.04.21.719669 | 1 | Layer-5 Pyramidal Cell tLTD Requires Astrocytic Ca2+ and CB1 Receptor Signaling | [
"Watanabe, A.",
"Guo, C.",
"Alageswaran, S.",
"Sjostrom, P. J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719669v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Synaptic plasticity is considered a cornerstone of memory formation ( Bliss and Collingridge, 1993 ; Malenka and Bear, 2004 ; Nabavi et al., 2014 ) and a key mechanism in the developmental refinement of neu... |
biorxiv | 10.64898/2026.04.21.719633 | 10.64898/2026.04.21.719633 | 1 | A new phased assembly of the Antarctic spiny plunderfish provides novel insights into the evolution of the notothenioid radiation. | [
"Martelossi, J.",
"Krasheninnikova, K.",
"Denton, A.",
"Wood, J. M. D.",
"Mathers, T.",
"Durbin, R.",
"Fong, N.",
"Bentley, D. L.",
"Clark, M. S.",
"Bista, I."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719633v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Background"
},
{
"type": "para",
"text": "The notothenioids are one of the most diverse and dominant fish groups in the Southern Ocean and a rare example of a well characterised marine flock species [ 1 ]. The clade is formed by approximately 140 spe... |
biorxiv | 10.64898/2026.04.21.719525 | 10.64898/2026.04.21.719525 | 1 | Aiki-XP: leakage-controlled multimodal prediction of within-species relative protein expression at pan-bacterial scale | [
"Tien, H.",
"Meda, R. S.",
"Shastry, S.",
"Mysore, V."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719525v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Protein expression is an essential feature of life, required for growth, maintenance, and repair [ 42 ]. Understanding how genetic information is converted into protein molecules is critical for understandi... |
biorxiv | 10.64898/2026.04.21.719147 | 10.64898/2026.04.21.719147 | 1 | Development of species-specific real-time PCR assays for the identification of five European Rhinolophus bats. | [
"Wright, P.",
"Palacios, M. B.",
"Hargreaves, D.",
"Kitching, T.",
"Bücs, S.-L.",
"Budinski, I.",
"Bajic, B.",
"Jere, C.",
"Csösz, I.",
"Harry, I. C.",
"Etheridge, T.",
"Mathews, F."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719147v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Non-invasive genetic sampling is a critical tool in wildlife conservation as it can provide information on a species’ presence, population size or ecology without the need to disturb individuals. The detect... |
biorxiv | 10.64898/2026.04.21.718480 | 10.64898/2026.04.21.718480 | 1 | TAR syndrome causal gene RBM8A is critical for embryonic bone development and proper Hedgehog signaling | [
"Mott, J.",
"Pei, Z.",
"Sun, J.",
"Lee, C. H.",
"Puri, T.",
"Sachs, Z. M.",
"Aviles Vargas, A.",
"Blaha, N.",
"Tong, M.",
"Liu, A.",
"Wang, Y.",
"Kim, Y.",
"Girirajan, S.",
"Zhang, J.",
"Mao, Y."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.718480v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Birth defects impacting skeletal and craniofacial development are among the most common congenital diseases, representing some of the urgent unmet medical needs across the world 1 . The prevalence of major ... |
biorxiv | 10.64898/2026.04.20.719776 | 10.64898/2026.04.20.719776 | 1 | Cardiac-Detargeted MyoAAV Enables Systemic Nrl-Mediated Fast Myofiber Remodeling and Hypertrophy Across Multiple Skeletal Muscles | [
"Hitachi, K.",
"Sadaki, S.",
"Watanabe, M.",
"Tsuji, R.",
"Kubo, A.",
"Yamasaki, Y.",
"Kiyofuji, Y.",
"Inui, M.",
"Kudo, T.",
"Suzuki, T.",
"Takahashi, S.",
"Tsuchida, K.",
"Fujita, R."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719776v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Skeletal muscle is the most abundant tissue in the body and plays critical roles in locomotion, posture, thermogenesis, and metabolic homeostasis. In addition to these mechanical and metabolic functions, sk... |
biorxiv | 10.64898/2026.04.20.719753 | 10.64898/2026.04.20.719753 | 1 | Proximity-Aware Graph Attention Networks for Spatially Resolved Cell-Cell Inference | [
"Dubois, L.",
"Petrov, A.",
"Jack, J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719753v1 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "I ntroduction"
},
{
"type": "para",
"text": "Intercellular communication is the molecular backbone of tissue organization. Cells coordinate their behavior through a rich repertoire of secreted ligands, surface receptors, gap junctions, and extracellu... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.