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|---|---|---|---|---|---|---|---|---|---|
biorxiv | 10.64898/2026.04.24.720538 | 10.64898/2026.04.24.720538 | 1 | X chromosome association analyses using multiple models identifies 18 genetic loci influencing dietary intake in UK Biobank | [
"Brasher, M. S.",
"Sutton, K. J.",
"Patterson, W. B.",
"Cole, J. B."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720538v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Dietary intake is a leading risk factor for many common, noncommunicable diseases, including type 2 diabetes, obesity, and cardiovascular disease [ 1 , 2 ]. The 2017 Global Burden of Diseases, Injuries, and... |
biorxiv | 10.64898/2026.04.24.720406 | 10.64898/2026.04.24.720406 | 1 | Selective Editing and Functionalization of the Mammalian Lipidome | [
"Wang, B.",
"Luethy, L.",
"Tenney, L.",
"Qi, L.",
"Harayama, T.",
"Ekroos, K.",
"Morstein, J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720406v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Lipids are central to cellular organization, metabolism, and signaling, yet they remain one of the least tractable classes of biomolecules for systematic functional interrogation. 1 – 3 Lipid databases such... |
biorxiv | 10.64898/2026.04.24.719751 | 10.64898/2026.04.24.719751 | 1 | BAG2 Condensates Couple Proteostasis to CD8+T Cell Surveillance | [
"Almeida, M. C.",
"Wang, T.",
"Longhini, A. P.",
"Lobo, S.",
"Camargo, C. M.",
"Tinkle, E. D.",
"Kwon, M.",
"Duarte, G. Z.",
"Hirsch, I. O.",
"Ribeiro, C. A. J.",
"Ribeiro, F. A. O.",
"Shell, M. S.",
"Shea, J.-E.",
"Steen, J. A.",
"Kosik, K. S.",
"Carrettiero, D. C."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.719751v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Proteome integrity relies not only on intracellular protein quality control but also on immune surveillance mechanisms that determine outcomes from cell survival to cell elimination 1 , 2 . While the pathwa... |
biorxiv | 10.64898/2026.04.23.720522 | 10.64898/2026.04.23.720522 | 1 | Helminth infection dynamics in rehabilitating Javan slow lorises are driven by time since deworming rather than host traits | [
"Langgeng, A.",
"Sigaud, M.",
"Prameswari, W.",
"Priambada, N. P.",
"Rianti, P.",
"Moore, R.",
"MacIntosh, A. J.",
"Matsuda, I."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720522v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Parasites constitute dynamic components of primate ecosystems, shaping host health, survival, and population processes across both wild and managed environments. Rather than representing static indicators o... |
biorxiv | 10.64898/2026.04.23.720508 | 10.64898/2026.04.23.720508 | 1 | Deep Learning-Guided Holotomography Reveals Early Structural Remodelling During Pluripotency Exit | [
"Park, H.",
"Kim, G.",
"Shin, J.",
"Kim, S.-H.",
"Hwang, E.-b.",
"Kim, M.",
"Hwang, T.",
"Lim, A.",
"Yoon, G.",
"Park, J.",
"Jeon, Y.-w.",
"Kim, N.-S.",
"Park, Y.",
"Yoon, K.-J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720508v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Human pluripotent stem cells (hPSCs), comprising human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), have revolutionised the ability to model functional human tissues in a ... |
biorxiv | 10.64898/2026.04.23.720457 | 10.64898/2026.04.23.720457 | 1 | Predictive pursuit emerges in high-dimensional recurrent neural networks | [
"Redman, W. T.",
"Dinc, F. D.",
"Lin, X.",
"Chan, M. G.",
"Alexander, A. S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720457v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Pursuit is a ubiquitous behavior in biology, with a wide a range of organisms chasing others for predation and reproduction. In cases where the pursuer is faster than its target, moving to minimize the rela... |
biorxiv | 10.64898/2026.04.23.720454 | 10.64898/2026.04.23.720454 | 1 | Shifts in consumer assemblages are linked to nutrient availability and ecosystem metabolism | [
"Sadler, I.",
"Stanley, A.",
"Narr, C. F."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720454v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Nutrient availability influences many ecosystem processes, often limiting primary production ( Hecky and Kilham 1988 , Elser et al. 2007 ). Increases in nutrients like nitrogen (N) and phosphorus (P) can st... |
biorxiv | 10.64898/2026.04.23.720428 | 10.64898/2026.04.23.720428 | 1 | An Extended Clade Framework for Annotated Trees in the Context of Phylogeography and Transmission Tree Inference | [
"Berling, L.",
"Colijn, C."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720428v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Bayesian phylogenetic inference using Markov chain Monte Carlo (MCMC) methods produces large samples from a posterior distribution over phylogenetic trees. These samples represent uncertainty in both tree t... |
biorxiv | 10.64898/2026.04.23.720427 | 10.64898/2026.04.23.720427 | 2 | Comparison scanning generalized eigendecomposition separates temporal dynamics of alpha oscillations during inhibition of spatialized acoustic distractors. | [
"Harlow, T. J.",
"Korsu, H.",
"Almotwaly, L.",
"Corcoran, M. I.",
"Cole, S.",
"Chrobak, J. J.",
"Read, H. L."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720427v2 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Selective attention enables individuals to focus on foreground speech while ignoring task-irrelevant background sounds, which is essential for functioning in everyday auditory environments. However, the neu... |
biorxiv | 10.64898/2026.04.23.720424 | 10.64898/2026.04.23.720424 | 1 | Micromolar concentrations of metabolites enable coexistence of bacterial species in chemostats | [
"Ulrich, E.",
"Mitri, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720424v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Bacterial communities perform diverse functions, from nitrogen and carbon fixation in soil to the breakdown of complex carbohydrates in the human colon [ Mylona et al., 1995 , Santos Correa et al., 2023 , B... |
biorxiv | 10.64898/2026.04.23.720414 | 10.64898/2026.04.23.720414 | 1 | Bidirectional regulation between circadian feeding behavior and specialized midgut clocks in Drosophila | [
"Wu, B.",
"JA, W."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720414v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Circadian rhythms align physiology and behavior with daily environmental cycles to promote survival and fitness 1 , 2 . These rhythms are coordinated by central pacemakers in the brain that synchronize peri... |
biorxiv | 10.64898/2026.04.23.720405 | 10.64898/2026.04.23.720405 | 1 | Molecular methods reveal responses of bacterial communities, including indicator species, to ballast water management | [
"Brown, S. A.",
"Keely, S. P.",
"Brinkman, N.",
"Laroche, O.",
"Zaiko, A.",
"Molina, V.",
"First, M.",
"Drake, L.",
"Darling, J. A."
] | CC0-1.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720405v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The translocation of living organisms in ballast water (BW) is a significant driver of global biotic exchange in aquatic environments and has been responsible for numerous biological invasions with devastat... |
biorxiv | 10.64898/2026.04.23.720403 | 10.64898/2026.04.23.720403 | 1 | The Rhythm of Normality: A Comprehensive Normative Database for TMS-EEG Metrics with Reliability Characterization | [
"Couto, B. A. N.",
"De Martino, E.",
"Mazhari-Jensen, D.",
"Jakobsen, A.",
"Bach, M. M.",
"Gianotta, A.",
"Ingemann-Molden, S.",
"Graven-Nielsen, T.",
"Casali, A. G.",
"de Andrade, D. C."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720403v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) provides a powerful approach for non-invasive interrogation of human cortical physiology ( Ziemann et al., 2026 ).... |
biorxiv | 10.64898/2026.04.23.720380 | 10.64898/2026.04.23.720380 | 2 | Cell material state determines high-frequency cell deformation and microbubble-induced permeabilization | [
"Sloan, S. P.",
"Pattinson, O.",
"Ben Issa, A. A.",
"Stride, E.",
"Tilley, S.",
"Kanczler, J.",
"Carugo, D.",
"Pierron, F.",
"Evans, N. D."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720380v2 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Cells and tissues are viscoelastic materials whose mechanical properties influence how they deform, dissipate energy and respond biologically to applied forces 1 . Most experimental approaches in cell mecha... |
biorxiv | 10.64898/2026.04.23.720371 | 10.64898/2026.04.23.720371 | 1 | All Models are Wrong, Some are Annotated: Automating Metadata in Biomedical Repositories | [
"Cohen, I.",
"Yu, H.",
"McDougal, R. A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720371v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Metadata is a cornerstone of modern scientific databases. 1 By providing structured descriptions that capture what data represent, how they were generated, and where they were used, metadata enables raw fil... |
biorxiv | 10.64898/2026.04.23.720368 | 10.64898/2026.04.23.720368 | 1 | Macronutrient Composition and Genetic Background Determine the Response to a Ketogenic Diet | [
"Zhang, Z.",
"Moura-Assis, A.",
"Liu, S.",
"Millet, A.",
"Shaked, J.",
"Rajan, D.",
"Alwaseem, H.",
"Isay-Del Viscio, M.",
"Molina, H.",
"Birsoy, K.",
"Friedman, J. M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720368v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Genetic and environmental factors both contribute to the development of obesity in humans and mice 1 . In humans, twin studies, adoption studies, studies of familial aggregation as well as molecular genetic... |
biorxiv | 10.64898/2026.04.23.720356 | 10.64898/2026.04.23.720356 | 2 | A cellular automaton model of osteogenic differentiation reveals identifiability limits of endpoint assays | [
"Demir, A. A.",
"Combriat, T.",
"Heyward, C. A.",
"Tiainen, H.",
"Carlier, A.",
"Dysthe, D. K."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720356v2 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Biomineralization describes the formation and organization of inorganic phases in biological systems [ 1 ]. In mammalian bone, this process is driven by osteogenic differentiation, a regulated program that ... |
biorxiv | 10.64898/2026.04.23.720352 | 10.64898/2026.04.23.720352 | 2 | MycorrhizaTracer: A BIOINFORMATIC PIPELINE FOR FUNGI AND PLANT CLASSIFICATION OF SANGER DNA SEQUENCES | [
"Brekke, T. D.",
"Weeks, T.",
"Barber, R. A.",
"Thomson, I.",
"Gooda, R.",
"Gargiulo, R.",
"Delhaye, G.",
"Andrew, C.",
"Kowal, J.",
"Bidartondo, M.",
"Suz, L. M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720352v2 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "In ecological sampling and biodiversity research, Sanger sequencing continues to serve as a dependable and accessible tool for species identification. Its proven accuracy, straightforward protocols, and mod... |
biorxiv | 10.64898/2026.04.23.720351 | 10.64898/2026.04.23.720351 | 1 | Metabolic-secretory decoupling defines a disease-intrinsic state in rheumatoid arthritis monocytes | [
"Teoh, S. T.",
"Malkewitz, S.",
"Iperi, C.",
"Makowiec, C.",
"Kakale, A.",
"Duphey, S. M.",
"Boersch, A.",
"Buczak, K.",
"Wolski, W.",
"Yang, M.",
"Frezza, C.",
"Ospelt, C.",
"Distler, O.",
"Kyburz, D.",
"Mueller-Durovic, B."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720351v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by persistent synovial inflammation, progressive joint destruction, and substantial systemic manifestations. Although adaptiv... |
biorxiv | 10.64898/2026.04.23.720328 | 10.64898/2026.04.23.720328 | 1 | Concomitant DNA hydroxymethylation and histone H2B O-GlcNAcylation are prerequisites for zygotic genome activation in mice | [
"Nakamura, T.",
"Furuta, A.",
"Nakatani, T.",
"Nakano, T."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720328v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Zygotic genome activation (ZGA) is a critical nuclear reprogramming event that transitions the genome from a quiescent state to robust transcriptional activity shortly after fertilization. In mice, transcri... |
biorxiv | 10.64898/2026.04.23.720326 | 10.64898/2026.04.23.720326 | 3 | Surface functionalization of small extracellular vesicles derived from Caco-2 and HEK293T cells in the neutralization of Shiga toxin 1 subunit B | [
"Mikolajczyk, K.",
"Bereznicka, A.",
"Czernek, L.",
"Gualerzi, A.",
"Forleo, L.",
"Bedoni, M.",
"Lodej, N.",
"Migdal, P."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720326v3 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Shiga toxin-producing Escherichia coli (STEC) is a group of foodborne pathogens, belonging to multiple serotypes, which are characterized by the release of the Shiga toxins (Stx), its main virulence factor.... |
biorxiv | 10.64898/2026.04.23.720195 | 10.64898/2026.04.23.720195 | 2 | HuR Regulates GATA3-Driven Type 2 Inflammation in CD4⁺ T cells and ILC2 in Airway Inflammation | [
"Atasoy, U.",
"Fattahi, F.",
"Yaekle, L.",
"Holden, J.",
"Tepper, B.",
"Hussein, K.",
"Meier, J.",
"Xu, L.",
"Nerella, S.",
"Lei, J.",
"Bentley, K.",
"Hershenson, M.",
"Huang, S. K."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720195v2 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Allergic asthma remains a major cause of chronic respiratory morbidity worldwide, affecting approximately 300 million individuals around the world and 25 million in the United States alone, and contributing... |
biorxiv | 10.64898/2026.04.23.720145 | 10.64898/2026.04.23.720145 | 1 | PPM1B utilizes a trinuclear metal architecture for phosphatase activity | [
"Stevens, R. P.",
"Solodushko, V.",
"Wierzbicki, A.",
"Rich, T. C.",
"Alexeyev, M. F.",
"Thompson, M. K.",
"Stone, M.",
"Hall, C.",
"deWeever, A.",
"Sayner, S. L.",
"Stevens, T.",
"Andrews, J.",
"Prakash, A.",
"Honkanen, R. E.",
"Lee, J. Y.",
"Salter, E. A.",
"Swingle, M. R."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720145v1 | 2026-04-27T00:00:00 | [
{
"type": "para",
"text": "Innate immune signaling relies on reversible protein phosphorylation to control the timing and magnitude of host defense responses 1 – 8 . Although kinase-driven pathway activation has been extensively characterized, far less is known about how phosphatases execute signal terminat... |
biorxiv | 10.64898/2026.04.23.719849 | 10.64898/2026.04.23.719849 | 1 | Metal-induced energy transfer uncovers activation-induced axial reorganization of signaling complexes inside cells | [
"Wienbeuker, E.",
"Felker, A.",
"Nevskyi, O.",
"Harms, S. T.",
"Marx, D.",
"Tanzusch, K.",
"Chizhik, A.",
"Kurre, R.",
"You, C.",
"Enderlein, J.",
"Piehler, J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.719849v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Multicellular organisms rely on elaborate intercellular communication networks in which a multitude of biochemical messengers is recognized by cognate receptors at the cell surface. Binding of messengers to... |
biorxiv | 10.64898/2026.04.23.719809 | 10.64898/2026.04.23.719809 | 1 | Subcellular dynamics of leghemoglobin is modulated by its site-specific serine phosphorylation during symbiotic nitrogen fixation in Lotus japonicus | [
"ASHRAFI, M. A.",
"DAS, A.",
"SIDDHANTA, A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.719809v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The symbiotic relationship between leguminous plants and nitrogen-fixing rhizobia is a cornerstone of sustainable agriculture, culminating in the formation of root nodules where atmospheric dinitrogen (N 2 ... |
biorxiv | 10.64898/2026.04.22.720181 | 10.64898/2026.04.22.720181 | 3 | State-dependent energy conversion produces degenerate dissipation in active actomyosin networks | [
"Sun, Z. G.",
"Zheng, J.",
"Tabatabai, A. P.",
"Vlassak, J.",
"Murrell, M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720181v3 | 2026-04-25T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "In non-equilibrium systems, increased driving is commonly assumed to amplify energy dissipation, reflecting intuition inherited from linear response theory and irreversible thermodynamics 1 – 6 . This intui... |
biorxiv | 10.64898/2026.04.22.719985 | 10.64898/2026.04.22.719985 | 2 | Heterophilic interactions between cell-surface proteins Teneurin-m and Capricious drive dendrite segregation in the Drosophila olfactory circuit | [
"Ji, H.",
"Li, J.",
"Xu, Y.",
"Wong, K. K. L.",
"Wu, Y.",
"Luginbuhl, D. J.",
"Zhang, Y.",
"Li, Z.",
"Lee, J.",
"Jones, R. C.",
"Quake, S. R.",
"Arac, D.",
"Özkan, E.",
"Luo, L."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.719985v2 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The assembly of functional neural circuits requires neurons to elaborate dendritic arbors that occupy specific territories. In many systems, dendrites of different neuronal types segregate into discrete, no... |
biorxiv | 10.64898/2026.04.21.719839 | 10.64898/2026.04.21.719839 | 2 | Genomic basis of rapid urban evolution revealed by the subgenome-resolved genome of octoploid Oxalis corniculata | [
"Iimura, H.",
"Sato, M. P.",
"Aoyagi, Y. B.",
"Kikuchi, S.",
"Tachiki, Y.",
"Uchida, K.",
"Katsuhara, K. R.",
"Hiraoka, K.",
"Fukano, Y.",
"Shirasawa, K."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719839v2 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Urbanization is one of the fastest and most widespread forms of environmental change on Earth ( Seto et al., 2011 ; Seto et al., 2012 ). Cities impose strong and often repeatable selection pressures through... |
biorxiv | 10.64898/2026.04.21.719792 | 10.64898/2026.04.21.719792 | 2 | Epithelial NCAPD3 expression protects against stress-induced intestinal injury in mice | [
"Johnston, I.",
"Johnson, E. E.",
"Khan, A.",
"Longworth, M. S.",
"McDonald, C."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719792v2 | 2026-04-21T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The intestinal epithelium is a vital single-cell barrier between the host and the external environment, consisting of a diverse range of specialized intestinal epithelial cells (IECs) ( 1 ). This dynamic in... |
biorxiv | 10.64898/2026.04.17.719192 | 10.64898/2026.04.17.719192 | 2 | Energetic misfires: Hybridization drives transgressive expression in metabolic pathways in thermally divergent Icelandic stickleback | [
"Brachmann, M. K.",
"Smith, B.",
"Kristjansson, B.",
"Selman, C.",
"Parsons, K."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.17.719192v2 | 2026-04-18T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Climate change presents an ever-worsening threat to biodiversity (IPCC, 2021) as continued warming pushes species to their thermal limits ( Nunez et al., 2019 ). Ectotherms are expected to be particularly v... |
biorxiv | 10.64898/2026.04.06.716549 | 10.64898/2026.04.06.716549 | 2 | Endogenous nucleophilic scavengers of reactive acyl-species neutralize carbon stress | [
"Lee, M.-K.",
"Kim, S. M.",
"Lee, S.",
"Yang, J. H.",
"Choi, C. R.",
"Miao, T.",
"Kim, J.-S.",
"Perrimon, N.",
"Kang, Y. P.",
"Rhee, H.-W."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.06.716549v2 | 2026-04-08T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Protein damage is a fundamental driver of aging and metabolic diseases ( 1 , 2 ) Emerging evidence highlights carbon stress—the accumulation of damage from reactive acyl species (RAS) ( 3 – 5 )—as a critica... |
biorxiv | 10.64898/2026.02.04.703630 | 10.64898/2026.02.04.703630 | 2 | Unified imputation of missing data modalities and features in multi-omic data via shared representation learning | [
"Nambiar, A.",
"Melendez, C.",
"Noble, W. S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.02.04.703630v2 | 2026-02-06T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Diseases arise from complex interactions among molecules, pathways, and cells across biological scales. For example, genetic variants can alter transcriptional regulation and protein function, which in turn... |
biorxiv | 10.64898/2026.01.29.702536 | 10.64898/2026.01.29.702536 | 2 | Bottom trawling impacts on faunal and microbial communities increase seafloor carbon loss | [
"Bonthond, G.",
"Beermann, J.",
"Wrede, A.",
"Sidorenko, V.",
"Schupp, P. J.",
"Gutow, L."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.01.29.702536v2 | 2026-01-30T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Marine sediments cover nearly 70% of Earth’s surface and critically contribute to the long-term storage of organic matter (OM), of which organic carbon (OC) is the major constituent ( Snelgrove et al . 2014... |
biorxiv | 10.64898/2026.01.06.697875 | 10.64898/2026.01.06.697875 | 2 | Arousal modulates functional connectivity through structured and hemispherically asymmetric community architecture during wakefulness | [
"Kong, X.",
"Li, S.",
"Gong, G."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.01.06.697875v2 | 2026-01-06T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Arousal is a core dimension of brain state that shapes perception, attention, and the coordination of large-scale neural systems. Across major transitions—such as wakefulness to sleep, anesthesia, or disord... |
biorxiv | 10.64898/2026.01.04.697520 | 10.64898/2026.01.04.697520 | 2 | Cure-screening predicts mechanism of post-antibiotic relapse in Tuberculosis | [
"Michael, C. T.",
"Budak, M.",
"Lin, P. L.",
"Kirschner, D. E."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.01.04.697520v2 | 2026-01-05T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Pulmonary tuberculosis (TB) remains a dire concern for countries across the globe and requires months of intensive treatment. A staggering one-quarter of the human population is infected with Mycobacterium ... |
biorxiv | 10.64898/2025.12.15.694023 | 10.64898/2025.12.15.694023 | 3 | Neuroligin-2 is ubiquitinated by Nedd4l to control developmental astrocyte morphogenesis. | [
"Sakers, K.",
"Ramirez, J. J.",
"Elazar, N.",
"Nagendren, L.",
"Soderblom, E. J.",
"Eroglu, C."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2025.12.15.694023v3 | 2025-12-16T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Protoplasmic astrocytes of the central nervous system (CNS) have a unique bush-like morphology. The molecular mechanisms that govern how astrocytes develop their complex structure are largely unknown. Astro... |
biorxiv | 10.64898/2025.12.04.692398 | 10.64898/2025.12.04.692398 | 3 | Uniform pre-processing of bacterial single-cell RNA-seq | [
"Oakes, C. G.",
"Beilinson, V.",
"McFall-Ngai, M. J.",
"Pachter, L. G."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2025.12.04.692398v3 | 2025-12-06T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Single-cell RNA sequencing has transformed eukaryotic cell analysis by allowing an improved understanding of diversity at the individual-cell level. However, implementation of single-cell transcriptomics in... |
biorxiv | 10.64898/2025.12.04.691931 | 10.64898/2025.12.04.691931 | 3 | Gut microbial interaction networks control autoimmunity to neuroretina | [
"Zhang, A.",
"Horai, R.",
"Jittayasothorn, Y.",
"Badger, J. H.",
"Wu, Z.",
"Shi, G.",
"Gupta, A.",
"Arunkumar, S.",
"Murphy, C. E.",
"Nagarajan, V.",
"McCulloch, J. A.",
"Kodati, S.",
"Sen, H. N.",
"Lee, J. W.",
"Jacobs, J. P.",
"Xu, X.",
"Mattapallil, M. J.",
"Peng, Z.",
"Xu, B.... | CC0-1.0 | https://www.biorxiv.org/content/10.64898/2025.12.04.691931v3 | 2025-12-06T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Immune-privileged tissues are increasingly recognized as sites where host–microbiota interactions influence immunological balance in autoimmune and inflammatory diseases 3 , 4 . Multiple mechanisms have bee... |
biorxiv | 10.64898/2025.12.02.691902 | 10.64898/2025.12.02.691902 | 2 | The language network responds robustly to sentences across diverse tasks | [
"Gao, R.",
"Cheung, C.",
"Siegelman, M.",
"Pongos, A. L. A.",
"Kean, H. H.",
"Tanner, A.",
"Fedorenko, E.",
"Ivanova, A. A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2025.12.02.691902v2 | 2025-12-05T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The human brain has a dedicated set of regions for processing language ( Fedorenko et al., 2024 ). These regions, known as the language network, respond to a broad range of linguistic conditions across mult... |
biorxiv | 10.1101/2025.11.24.690121 | 10.1101/2025.11.24.690121 | 6 | Different stabilizing mechanisms but a common task-level aim in standing and walking | [
"Geng, Y.",
"van Dieen, J. H.",
"Bruijn, S. M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.11.24.690121v6 | 2025-11-26T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Standing and walking are two fundamental motor behaviors in human daily life. Both require sophisticated neuromuscular control to maintain an upright body orientation against the effects of unpredictable pe... |
biorxiv | 10.1101/2025.11.19.689397 | 10.1101/2025.11.19.689397 | 2 | Omicron evolution drives increased ciliated cell tropism and dysfunction in nasal epithelia. | [
"Mostafavi, H.",
"Parry, R.",
"McCallum, G.",
"Sng, J. D. J.",
"Joensuu, M.",
"Short, K. R.",
"Slonchak, A.",
"Khromykh, A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.11.19.689397v2 | 2025-11-20T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The upper respiratory tract is the primary site of infection with SARS-CoV-2 ( 1 ). The nasal mucosa is populated by a variety of different cells, including goblet cells, ciliated cells, mucus-producing cel... |
biorxiv | 10.1101/2025.11.06.686941 | 10.1101/2025.11.06.686941 | 2 | Experimental evidence of male-male interaction in laboratory swarms of Anopheles gambiae mosquitoes | [
"Iacomelli, G.",
"Lombardi, M.",
"Parisi, L.",
"Fiorini, M.",
"Grucci, F.",
"Lavorgna, A.",
"Ligato, M.",
"Zarcone, G.",
"Peirce, M. J.",
"Melillo, S.",
"Spaccapelo, R."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.11.06.686941v2 | 2025-11-07T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Collective behavior is a widespread phenomenon, observed across many biological systems, from cells in a colony to vertebrates in a herd. It emerges when a large number of individuals self-organize and, thr... |
biorxiv | 10.1101/2025.11.03.686160 | 10.1101/2025.11.03.686160 | 2 | Multi-ancestry Transcriptome-Wide Association Study Reveals Shared and Population-Specific Genetic Effects in Alzheimer's Disease | [
"Sun, X.",
"Mews, M.",
"Wheeler, N. R.",
"Benchek, P.",
"Gu, T.",
"Gomez, L.",
"Ray, N.",
"Reitz, C.",
"Naj, A. C.",
"Below, J. E.",
"Tosto, G.",
"Cornejo-Olivas, M.",
"Byrd, G. S.",
"Feliciano-Astacio, B. E.",
"Celis, K.",
"Rajabli, F.",
"Kunkle, B. W.",
"Pericak-Vance, M. A.",
... | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.11.03.686160v2 | 2025-11-05T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Alzheimer’s Disease (AD) is the most common form of dementia and affects millions worldwide, with its prevalence expected to increase significantly as global populations age 1 . AD is heritable, though AD r... |
biorxiv | 10.1101/2025.10.23.684253 | 10.1101/2025.10.23.684253 | 4 | Suppressing Primer-Driven Nonspecific Amplification in LAMP Using TrueLAMP | [
"Chen, Z."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.10.23.684253v4 | 2025-10-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Loop-mediated isothermal amplification (LAMP) has become a prominent method for rapid nucleic acid detection due to its high amplification efficiency and operation under isothermal conditions, making it ide... |
biorxiv | 10.1101/2025.10.16.682983 | 10.1101/2025.10.16.682983 | 2 | Single Domain Antibody Inhibitors Target the Coiled Coil Arms of the Bacillus subtilis SMC complex | [
"Gosselin, O.",
"Taschner, M.",
"Huber-Hürlimann, L.",
"Seeger, M. A.",
"Gruber, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.10.16.682983v2 | 2025-10-17T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Rapid and specific interference with protein activity and dynamics in living cells is essential for studying and understanding biological mechanisms. However, current approaches—primarily based on small-mol... |
biorxiv | 10.1101/2025.10.12.681832 | 10.1101/2025.10.12.681832 | 3 | Transcriptional regulation of disease-relevant microglial activation programs | [
"McQuade, A.",
"Mishra, R.",
"Hagan, V.",
"Liang, W.",
"Colias, P.",
"Castillo, V. C.",
"Gonzalez, B.",
"Lubin, J.",
"Haage, V.",
"Marshe, V.",
"Fujita, M.",
"Ta, T.",
"Gomes, L.",
"Teter, O.",
"Han, X.",
"Robichaud, N.",
"Chasins, S. E.",
"Rexach, J. E.",
"De Jager, P. L.",
"N... | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.10.12.681832v3 | 2025-10-13T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Microglia are highly plastic brain-resident macrophages that continuously monitor the parenchyma to support cognitive function and brain health 1 , 2 . In response to insult or injury, microglia rapidly tri... |
biorxiv | 10.1101/2025.09.23.674728 | 10.1101/2025.09.23.674728 | 2 | Exploring the impact of social relevance on the cortical tracking of speech: viability and temporal response characterisation | [
"Ip, E. Y. J.",
"Akkaya, A.",
"Winchester, M. M.",
"Bishop, S. J.",
"Cowan, B. R.",
"Di Liberto, G. M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.09.23.674728v2 | 2025-09-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "To understand speech, our brains must rapidly process sounds into linguistic meaning ( Friederici, 2011 ; Poeppel et al., 2012 ). The neural basis of this phenomenon has been studied extensively using contr... |
biorxiv | 10.1101/2025.09.12.672331 | 10.1101/2025.09.12.672331 | 2 | Risk Based Prediction of Novel AMR Variants Using Protein Language Models | [
"Wood, J. J.",
"Portelli, S.",
"Ascher, D. B.",
"Furnham, N."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.09.12.672331v2 | 2025-09-12T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The emergence and spread of Antimicrobial resistance (AMR) is fast becoming a global public health crisis, with drug-resistant infections already causing an estimated 700,000 deaths annually, projected to r... |
biorxiv | 10.1101/2025.08.27.672553 | 10.1101/2025.08.27.672553 | 2 | Eight years of social and individual learning synergistically shape orangutan diet profiles | [
"Revathe, T.",
"Weidling, M.-T.",
"Utami-Atmoko, S. S.",
"Setia, T. M.",
"Razik, I.",
"van Schaik, C. P.",
"Whiten, A.",
"Buerkner, P.-C.",
"Schuppli, C."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.08.27.672553v2 | 2025-09-01T00:00:00 | [
{
"type": "para",
"text": "Until as recently as the middle of the last century, culture was thought to be a feature of humanity that separates our species from the remainder of the animal kingdom ( 1 ). Recent research has revealed that to the contrary, culture defined as “information capable of affecting i... |
biorxiv | 10.1101/2025.08.14.670362 | 10.1101/2025.08.14.670362 | 4 | Apathy-anhedonia is associated with pessimistic beliefs yet sharpened goal-directed planning | [
"Liang, S.",
"Russek, E. M.",
"Rutledge, R.",
"Wimmer, G. E."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.08.14.670362v4 | 2025-08-19T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "A common assumption in decision science is that subjective beliefs about uncertain outcomes guide value-based choice ( Rangel et al., 2008 ; Tversky and Kahneman, 1992 ). On this view, pessimistic expectati... |
biorxiv | 10.1101/2025.04.22.649952 | 10.1101/2025.04.22.649952 | 2 | Chromosome-scale genome assembly of the European common cuttlefish Sepia officinalis | [
"Rencken, S.",
"Tushev, G.",
"Hain, D.",
"Ciirdaeva, E.",
"Simakov, O.",
"Laurent, G."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.04.22.649952v2 | 2025-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Coleoid cephalopods (octopus, squid, cuttlefish) are a highly derived group of mollusks, characterized by the largest nervous systems among all invertebrates (ca. 500 million neurons in adult octopus of whi... |
biorxiv | 10.1101/2025.01.21.634178 | 10.1101/2025.01.21.634178 | 5 | Investigation of Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis | [
"Shimogawa, M.",
"Li, M.-H.",
"Park, G. S. H.",
"Ramirez, J.",
"Lee, H.",
"Watson, P.",
"Sharma, S.",
"Lin, Z.",
"Peng, C.",
"Lee, V. M.- Y.",
"Garcia, B.",
"Christianson, D. W.",
"Eliezer, D.",
"Rhoades, E.",
"Petersson, E. J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.01.21.634178v5 | 2025-01-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "α-Synuclein (αS) is a 14 kDa protein that typically exists at presynaptic terminals in healthy neurons, where its primary function is believed to be in synaptic vesicle trafficking and regulating neurotrans... |
biorxiv | 10.1101/2024.10.15.618147 | 10.1101/2024.10.15.618147 | 2 | Extensive monolayer formation after transplantation depends on a RPE subpopulation derived from human iPSCs | [
"Tessmer, K.",
"Gasparini, S. J.",
"Schmidtke, K.",
"Hammer, J.",
"Adhikari, T.",
"Michalke, L.",
"Schoen, A.",
"Loureiro, L.",
"Last, A.",
"Chelius, N.",
"Kurtz, A.",
"Johannsen, H.",
"Carido, M.",
"Ferguson, S.",
"Petzold, A.",
"Friedrich, U. A.",
"Kurth, T.",
"Dahl, A.",
"Feld... | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2024.10.15.618147v2 | 2024-10-15T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Deterioration of the retinal pigment epithelium (RPE), an epithelial monolayer separating choroid and neuroretina in the eye, causes retinal degeneration including dysfunction and loss of the light sensitiv... |
biorxiv | 10.64898/2026.04.24.720753 | 10.64898/2026.04.24.720753 | 1 | Biochemical and structural characterisation of MprF homologue,LpiA from Agrobacterium | [
"Dhole, S.",
"Sabharwal, P.",
"Kutti, V. R."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720753v1 | 2026-04-26T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "We have been interested in understanding the mechanism of the Multiple peptide resistance factor (MprF), a bi-functional enzyme that largely exists in bacteria. MprF has two domains, a transferase domain th... |
biorxiv | 10.64898/2026.04.24.720537 | 10.64898/2026.04.24.720537 | 1 | Selective Activation of Macrophage Innate Signaling Pathways and Inflammatory Responses to Orientia tsutsugamushi Karp and Gilliam Strains | [
"Villacreses, D.",
"Gonzales, C.",
"Zhang, Y.",
"Liang, Y.",
"Soong, L."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720537v1 | 2026-04-26T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Orientia tsutsugamushi (Ot) is a unique but poorly studied intracellular bacterium species, causing scrub typhus in humans. Unlike closely related bacteria in the Rickettsia genus, Ot exhibits a distinct ou... |
biorxiv | 10.64898/2026.04.24.720480 | 10.64898/2026.04.24.720480 | 1 | De novo design of a macrocycle induced dimerization system for cellular control | [
"Baker, D.",
"Hanna, S.",
"Salveson, P.",
"Wicky, B.",
"Kennedy, M.",
"Hicks, D.",
"Moller, C.",
"Cheng, S.",
"Li, X.",
"Abedi, M.",
"Coventry, B.",
"Said, M.",
"Bera, A. K.",
"Kang, A.",
"Stoddard, B. L."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720480v1 | 2026-04-26T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Chemically induced dimerization (CID) systems in which protein-protein association is dependent on membrane permeable small molecule ligands are broadly useful in synthetic biology to enable external contro... |
biorxiv | 10.64898/2026.04.23.720292 | 10.64898/2026.04.23.720292 | 2 | Realistic basin shape variation modulates local riverine biodiversity via altered connectivity | [
"Calabrese, J.",
"Garcia Andrade, A. B.",
"Ismail, I.",
"Colombo, E. H."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720292v2 | 2026-04-26T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Understanding the drivers of biodiversity in the world’s rivers, particularly for freshwater fishes, has been an enduring goal in aquatic ecology. Freshwater ecosystems in general, and rivers in particular,... |
biorxiv | 10.64898/2026.04.22.720257 | 10.64898/2026.04.22.720257 | 1 | Intranuclear Quantum Sensing with Fluorescent Nanodiamond Enabled by Electron-Irradiation and Surface-Chemical Optimization for Microinjection | [
"Kato, Y. S.",
"Shiraya, K.",
"Shimazaki, Y.",
"Gutz, A.",
"Fujimaki, D.",
"Abe, H.",
"Ohshima, T.",
"Fujita, K.",
"Harada, Y.",
"Sotoma, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720257v1 | 2026-04-26T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Quantum sensing using solid-state spin defects has opened new possibilities for visualizing and quantifying physical and chemical processes in living systems [ 1 ]. Fluorescent nanodiamonds (FNDs) embedded ... |
biorxiv | 10.64898/2026.04.22.720250 | 10.64898/2026.04.22.720250 | 1 | C. elegans models of Alternating Hemiplegia of Childhood have dominant neuromuscular junction defects | [
"Wall, D.",
"Friedberg, A.",
"Lins, J.",
"Khalifa, R.",
"Partipilo, S.",
"Hart, A. C."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720250v1 | 2026-04-26T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Mutations in ATP1A3 cause a spectrum of disorders with overlapping neurological and developmental symptoms ( Vezyroglou et al. 2022 ). Beyond symptomatic treatments, there are no effective therapies for ATP... |
biorxiv | 10.64898/2026.04.22.720214 | 10.64898/2026.04.22.720214 | 1 | A pcyt-1 Allelic Series Reveals In Vivo Consequences of Reduced Phosphatidylcholine Synthesis in C. elegans | [
"Qvist, A.",
"Kaper, D.",
"Henricsson, M.",
"Stjernman, A.",
"Boren, J.",
"Pilon, M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720214v1 | 2026-04-26T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Homodimeric PCYT1A is the rate-limiting enzyme in the synthesis of phosphatidylcholine (PC), the most abundant phospholipid in most eukaryotic cellular membranes ( Fig. 1A ) . Low PC levels lead to packing ... |
biorxiv | 10.64898/2026.04.22.720176 | 10.64898/2026.04.22.720176 | 1 | NbRD21 protease controls receptor kinase homeostasis in Nicotiana benthamiana | [
"Godson, A.",
"Eddie, L.",
"Schuster, M.",
"Zheng, K.",
"Toth, R.",
"Li, Y.",
"Li, T.",
"Huang, J.",
"Kaschani, F.",
"Jutras, P. V.",
"Kourelis, J.",
"Kaiser, M.",
"Bozkurt, T. O.",
"van der Hoorn, R. A. L."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720176v1 | 2026-04-26T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Responsive-to-Desiccation-21 (RD21) -like proteases are ubiquitous in angiosperm plants. These papain-like cysteine proteases (PLCPs) are typified by having a C-terminal granulin domain and are amongst the ... |
biorxiv | 10.64898/2026.04.22.720076 | 10.64898/2026.04.22.720076 | 1 | Coordinated beak-tongue mechanics enable dexterous seed manipulation in songbirds | [
"Mielke, M.",
"Mielke, F.",
"Gladman, N. W.",
"Tatulescu, D. A.",
"Herrel, A.",
"Elemans, C. P. H.",
"Van Wassenbergh, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720076v1 | 2026-04-26T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "For millions of years, birds and their ancestors have relied on seeds as their principal or complementary food source. Seeds are highly nutritious, energy-rich, and durable, and they have played an essentia... |
biorxiv | 10.64898/2026.04.21.719913 | 10.64898/2026.04.21.719913 | 1 | Opposing BOLD signals and oxygen metabolism largely arise from statistical uncertainty in metabolic estimates | [
"Goltermann, O.",
"Huth, A. R.",
"Büchel, C."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719913v1 | 2026-04-26T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "In a recently published study, Epp et al. (2025) report widespread voxel-wise discordance between functional magnetic resonance imaging (fMRI) based blood-oxygenation-level-dependent (BOLD) signal changes a... |
biorxiv | 10.64898/2026.04.21.719808 | 10.64898/2026.04.21.719808 | 1 | Temporal Dynamics of Cortical State Plasticity Following Adult Vision Loss | [
"Djerourou, I.",
"Ptito, M.",
"Vanni, M. P."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.21.719808v1 | 2026-04-26T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The mature brain retains a remarkable capacity for adaptation beyond the closure of critical periods of plasticity ( Gilbert & Li, 2012 ; Hübener & Bonhoeffer, 2014 ; H.-K. Lee & Whitt, 2015 ). Years after ... |
biorxiv | 10.64898/2026.04.20.719699 | 10.64898/2026.04.20.719699 | 1 | Evolutionary and functional diversification of cork oak NLRs reveals RNL expansion and dual roles in biotic and abiotic stress | [
"Goncalves, L. M.",
"Oliveira, M. M.",
"Barros, P. M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.20.719699v1 | 2026-04-26T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Rising temperatures, altered precipitation patterns and the increasing frequency of extreme weather events are examples of environmental shifts that bring significant challenges to ecosystems worldwide and ... |
biorxiv | 10.64898/2026.04.15.718636 | 10.64898/2026.04.15.718636 | 1 | Anopheles stephensi bionomics and epidemiology in Ethiopia: A systematic review and meta-analysis with implications for urban malaria control | [
"Wakuma, T. B.",
"Wakgari, K. L.",
"Gutema, A. D.",
"Jinfessa, L. R."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.15.718636v1 | 2026-04-26T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Malaria remains a significant economic and public health challenge in Ethiopia, which puts millions of people at risk of infection every year [ 1 – 4 ]. Ethiopia’s malaria burden leads to significant econom... |
biorxiv | 10.64898/2026.04.25.720756 | 10.64898/2026.04.25.720756 | 2 | A Genetic Method for Distinguishing Cryptic Pocillopora Species in French Polynesia without Sequencing | [
"Cohn, F. M.",
"Johnston, E.",
"Burgess, S.",
"Sims, J. A.",
"Layagala, K.",
"Harnay, P.",
"Putnam, H. M.",
"Correa, A. M. S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.25.720756v2 | 2026-04-25T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Pocillopora (Lamarck 1816) is a genus of scleractinian reef-building corals widespread across reefs and reef zones in the greater Indo-Pacific. Pocillopora is notoriously plastic in its morphology ( Todd 20... |
biorxiv | 10.64898/2026.04.24.720600 | 10.64898/2026.04.24.720600 | 1 | Dredd-mediated cleavage of Kenny uncouples the IKK complex from selective autophagy to enable innate immunity | [
"Mohan, A. K.",
"Dahlstrom, A. M.",
"Aalto, A. L.",
"Kotala, K.",
"Luukkonen, V.",
"Serenius, F.",
"Helin, E.",
"Rusten, T. E.",
"Meinander, A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720600v1 | 2026-04-25T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Autophagy is an evolutionary conserved process that maintains cellular homeostasis. In macroautophagy (hereafter referred to as autophagy), cytoplasmic cargo is engulfed by a double membrane isolation membr... |
biorxiv | 10.64898/2026.04.23.720377 | 10.64898/2026.04.23.720377 | 1 | Connections across regional glymphatic clearance, neural activity and amyloid-β deposition in cortex | [
"Li, Y.",
"Zhu, X.",
"zhou, y.",
"Zhang, X.",
"Zhou, Z.",
"Wei, K.",
"Sun, J.",
"Lou, M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720377v1 | 2026-04-25T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The accumulation of metabolic waste serves as a leading cause in multiple neurological diseases 1 . The brain’s remarkable neurocomputational capacity, supported by synchronized neuronal activity, inherentl... |
biorxiv | 10.64898/2026.04.23.720276 | 10.64898/2026.04.23.720276 | 1 | Mitochondrial mechanics nucleates axonal jamming and swelling | [
"Noerr, P. S.",
"Abushawish, A. A.",
"Pekkurnaz, G.",
"Rangamani, P."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720276v1 | 2026-04-25T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Neurons operate under exceptional energetic constraints imposed by their morphology and function [ 1 , 2 ]. Their polarized architecture enables compartmentalized information processing, but also necessitat... |
biorxiv | 10.64898/2026.04.23.720098 | 10.64898/2026.04.23.720098 | 1 | GPR180 deficiency impairs mitochondrial function and insulin secretion in pancreatic β-cells | [
"Antal, M.",
"Dahlby, T.",
"Makovicky, P.",
"Novak, A.",
"Horvath, C.",
"Stanikova, D.",
"Gazova, S.",
"Brumarova, R.",
"Ivanovova, E.",
"Horejsova, M.",
"Friedecky, D.",
"Krizanova, O.",
"Novotova, M.",
"Gasperikova, D.",
"Wolfrum, C.",
"Balaz, M.",
"Balazova, L."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720098v1 | 2026-04-25T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Pancreatic β-cells maintain glucose homeostasis by coupling nutrient metabolism to insulin secretion. Central to this process is mitochondrial oxidative metabolism, which links glucose-derived substrate flu... |
biorxiv | 10.64898/2026.04.22.720252 | 10.64898/2026.04.22.720252 | 1 | Lag phase length of IAPP amyloid formation predicts the duration of β-cell toxicity | [
"Plesner, A.",
"Cao, P.",
"Raleigh, D.",
"Abedini, A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720252v1 | 2026-04-25T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Aggregation of islet amyloid polypeptide (IAPP, amylin) contributes to β-cell dysfunction and loss in type 2 diabetes and in islet transplantation failure [ 1 – 5 ]. Although IAPP amyloidosis has long been ... |
biorxiv | 10.64898/2026.04.22.720209 | 10.64898/2026.04.22.720209 | 2 | Proteasome-dependent degradation and nucleus-vacuole junctions sustain proteostasis during acute glucose starvation | [
"Pravica, M.",
"Franic, D.",
"Bazdan, M.",
"Guzalic, D.",
"Bedalov, A.",
"Boban, M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720209v2 | 2026-04-25T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "To maintain proteostasis, eukaryotic cells rely on a complex network of molecular pathways collectively referred to as the protein quality control (PQC) system. This system prevents the accumulation of misf... |
biorxiv | 10.64898/2026.04.24.720702 | 10.64898/2026.04.24.720702 | 1 | Gene regulatory co-option drives birdsong neural circuit specialization | [
"Marquez, A. P.",
"Lagousis, C. R. M.",
"Katcher, E. G.",
"Rand, F.",
"Varadharaj, K.",
"Brainard, M. S.",
"Colquitt, B. M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720702v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The complexity of motor skills, such as forelimb dexterity and human speech, is correlated with an expansion and diversification of motor cortical domains [ 1 ]. Primates with fine control of the hands have... |
biorxiv | 10.64898/2026.04.24.720581 | 10.64898/2026.04.24.720581 | 2 | Image-grounded encoding models reveal distinct temporal profiles of naturalistic object and scene processing in the human brain | [
"Müller, N.",
"Scholte, H. S.",
"Groen, I. I. A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720581v2 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The human visual system can efficiently and rapidly process vast amounts of incoming visual information. The processed information forms the basis for a wide range of decisions, for example how to navigate ... |
biorxiv | 10.64898/2026.04.24.720558 | 10.64898/2026.04.24.720558 | 1 | Global-scale microbiome analyses identify an ancestral gut cyanobacterial lineage enriched in African populations | [
"Murai, K.",
"Suzuki, Y.",
"Nishijima, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720558v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The human gut microbiome plays a crucial role in maintaining immune and metabolic homeostasis, and its disruption is associated with diverse diseases 1 – 3 . Recent advances in high-throughput analysis tech... |
biorxiv | 10.64898/2026.04.24.720353 | 10.64898/2026.04.24.720353 | 1 | Collective protection drives human gut microbiota response to amoxicillin treatment. | [
"Lubrano, P.",
"Magnan, M.",
"Steiner, C.",
"Birgy, A.",
"Chassaing, B.",
"Deschasaux-Tanguy, M.",
"Gutierrez, A.",
"Barreto, H. C.",
"Hobson, C.",
"Magreault, S.",
"Jullien, V.",
"Lescat, M.",
"Tenaillon, O."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720353v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The remarkable gains in public health brought by antibiotics use are now under strain from the rise and spread of resistant bacteria. Once largely confined to hospitals, resistance has become a community-wi... |
biorxiv | 10.64898/2026.04.24.720349 | 10.64898/2026.04.24.720349 | 1 | Variation of anti-oomycete activity in Pseudomonas spp.: phenotypic characterization and comparative genomics | [
"Saric, E.",
"Miljanovic, A.",
"Struski, P.",
"Oberhaensli, S.",
"Zucko, J.",
"Schmidt-Posthaus, H.",
"Pavic, D.",
"Maguire, I.",
"Hermanns, J.",
"Pretto, T.",
"Bielen, A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720349v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Disease dynamics depends on the complex interplay between the host immune system and the pathogen ( Bernardo-Cravo et al., 2020 ), but various environmental parameters can modulate disease development. For ... |
biorxiv | 10.64898/2026.04.23.720515 | 10.64898/2026.04.23.720515 | 1 | Oral and gut microbiomes reveal latent physiological constraints on release readiness in rehabilitating Javan slow lorises | [
"Langgeng, A.",
"Sigaud, M.",
"Prameswari, W.",
"Priambada, N. P.",
"Rianti, P.",
"Sanchez, K. L.",
"Moore, R.",
"Lee, W.",
"MacIntosh, A. J. J.",
"Matsuda, I."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720515v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Across Southeast Asia, thousands of wild animals are displaced each year as a result of illegal wildlife trade and ongoing habitat degradation, entering rescue and rehabilitation systems that now function a... |
biorxiv | 10.64898/2026.04.23.720469 | 10.64898/2026.04.23.720469 | 1 | Structural variation shapes regulatory and evolutionary diversity at the HLA locus | [
"Canalda-Baltrons, A.",
"Silcocks, M.",
"Saunders, P. M.",
"Jackson, S. F.",
"Coin, L. J. M.",
"Dunstan, S. J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720469v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The human leukocyte antigen (HLA) region on chromosome 6 encodes the most polymorphic genes in the human genome and is central to adaptive immunity. Classical HLA class I and II molecules present peptide an... |
biorxiv | 10.64898/2026.04.23.720449 | 10.64898/2026.04.23.720449 | 1 | clootl: an R package for accessing and manipulating a complete, versioned avian phylogeny | [
"Miller, E.",
"Sanchez Reyes, L.",
"McTavish, E. J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720449v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "The research and conservation communities rely on access to a global avian phylogeny as a key resource to provide evolutionary context for their work. Although existing examples such as Jetz et al. (2012) ;... |
biorxiv | 10.64898/2026.04.23.720437 | 10.64898/2026.04.23.720437 | 1 | ER-associated control of axonal vesicle trafficking during neuronal development | [
"Subra, M.",
"Meehl, J. B.",
"Abrisch, R. G.",
"Voeltz, G. K."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720437v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Neuronal communication depends on the precise assembly of functional synapses during development. A key step in this process is the timely delivery and accumulation of presynaptic components to nascent syna... |
biorxiv | 10.64898/2026.04.23.720395 | 10.64898/2026.04.23.720395 | 1 | Pathogen-induced formation of a nascent organelle derived from mitochondria | [
"Pernas, L.",
"Li, X.",
"Sun, Y.",
"Delgado, J. M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720395v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Main Text"
},
{
"type": "para",
"text": "To establish nutrient-rich replicative niches and evade innate immune defenses, intracellular pathogens use diverse strategies to remodel cellular membranes, including through the reprogramming of membrane tra... |
biorxiv | 10.64898/2026.04.23.720359 | 10.64898/2026.04.23.720359 | 1 | Phylogenetic signal in herbicide resistance evolvability, and the use of phylogenies to predict herbicide resistance risk | [
"Brocklehurst, N.",
"Liu, C."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720359v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Weed management and control are vital in maintaining yields in agriculture, and herbicides provide an effective means of reducing weed populations. However, their use selects for resistant phenotypes in wee... |
biorxiv | 10.64898/2026.04.23.720297 | 10.64898/2026.04.23.720297 | 1 | Cultural transmission and genomic co-divergence in the willow tit across the Palearctic | [
"Syarifa, A.",
"Martens, J.",
"Päckert, M.",
"Kvist, L.",
"Wu, L.",
"Sun, Y.-H.",
"Wolf, J. B. W.",
"Knief, U."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720297v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The relative importance of prezygotic and postzygotic barriers in the speciation process is expected to vary among taxa. In birds, the striking diversity in mating and signalling traits between closely rela... |
biorxiv | 10.64898/2026.04.23.720277 | 10.64898/2026.04.23.720277 | 2 | Zero-shot design of a de novo metalloenzyme | [
"El Nesr, G.",
"Duerr, S. L.",
"Mathews, I. I.",
"Wen, Q.",
"Zhao, K.",
"Sarangi, R.",
"Roethlisberger, U.",
"Sunden, F.",
"Huang, P."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720277v2 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Main Text"
},
{
"type": "para",
"text": "Enzymes catalyze chemically demanding reactions with rate accelerations spanning many orders of magnitude ( 1 , 2 ). Achieving high levels of catalytic proficiency comparable to natural enzymes remains a long-... |
biorxiv | 10.64898/2026.04.23.719915 | 10.64898/2026.04.23.719915 | 1 | Additive baselines furnish no evidence for epistasis learning by MULTI-evolve | [
"Visani, G. M.",
"Verma, A.",
"DeWitt, W. S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.719915v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Tran et al . [ 1 ] present MULTI-evolve as a framework whose success hinges on learning epistatic interactions between mutations. Epistasis—the dependence of one mutation’s effect on the presence of others ... |
biorxiv | 10.64898/2026.04.22.720162 | 10.64898/2026.04.22.720162 | 1 | A Symphony of Genres: Driving Information Dynamics in Functional Brain Networks | [
"HaqiqiFar, A.",
"Shirmohammadi, A.",
"Yekta, A.",
"Jafari, G. R."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720162v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Music is one of the most complex and time-consuming things that the human brain processes on a regular basis. It works in a highly coordinated way with auditory, motor, attentional, and affective systems( K... |
biorxiv | 10.64898/2026.04.22.720141 | 10.64898/2026.04.22.720141 | 1 | Repetition-controllable gain-managed nonlinear fiber amplifier enables ultrashort, multiphoton imaging with reduced photodamage | [
"Read, J.",
"Xu, D.",
"Yan, J.",
"Rawlings, A.",
"Chugh, S.",
"Spalluto, M. C.",
"Elkington, P. T.",
"Kanczler, J.",
"Lane, S. I. R.",
"Mahajan, S.",
"Xu, L."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720141v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Multiphoton techniques, including fluorescence and harmonic based methods, have gained increasing popularity since their first use in the 1990s [ 1 - 3 ]. The principal multiphoton modalities include two- a... |
biorxiv | 10.64898/2026.04.22.720135 | 10.64898/2026.04.22.720135 | 1 | A Systematic Evaluation of Single-Cell Batch Integration Metrics and sBEE: A Robust New Metric | [
"Myradov, M.",
"HOUDJEDJ, A.",
"Tastan, O.",
"Kazan, H."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720135v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Single-cell RNA sequencing (scRNA-seq) has transformed the study of cellular heterogeneity ( Tanay et al., 2017 ; Luecken et al., 2019 ), enabling the discovery of rare cell populations and construction of ... |
biorxiv | 10.64898/2026.04.22.720134 | 10.64898/2026.04.22.720134 | 1 | Biophysical properties of material-colonizing fungal biofilms: multiscale structural and mechanical characterization | [
"Ferrari, C.",
"Dehkohneh, A.",
"Schumacher, J.",
"Ogawa, Y.",
"Gerrits, R.",
"Fratzl, P.",
"Gorbushina, A. A.",
"Bidan, C. M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720134v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Biofilms are surface-attached microbial communities embedded in self-produced extracellular polymeric substances (EPS) that protect the microorganisms from biological, chemical and physical challenges as we... |
biorxiv | 10.64898/2026.04.22.720126 | 10.64898/2026.04.22.720126 | 2 | Spatiotemporal Propagation of Sensorimotor Beta Bursts Across Adulthood | [
"Long, S.",
"Liu, X.",
"Mitsis, G. D.",
"Boudrias, M.-H."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720126v2 | 2026-04-23T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Beta-band oscillations (13–30 Hz) are a dominant feature of neural activity, detectable across spatial scales ranging from local extracellular recordings to whole-brain magnetoencephalography (MEG) ( Engel ... |
biorxiv | 10.64898/2026.04.22.720125 | 10.64898/2026.04.22.720125 | 1 | Comparative Analysis of Relative Ligand Binding Free Energy Simulation Methods: Amber-TI, GROMACS-NETI, OpenMM-FEP, and BLaDE-MSLD | [
"Lee, H.",
"Kim, I.",
"Kim, S.",
"Bae, M.",
"Jeong, B.",
"Kim, S.",
"Jo, S.",
"Lee, J.",
"Im, W."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720125v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Free energy calculations are essential tools in molecular simulations, providing quantitative insights into thermodynamic properties such as binding affinities, solvation free energies, and conformational s... |
biorxiv | 10.64898/2026.04.22.720086 | 10.64898/2026.04.22.720086 | 1 | A multiverse analysis of stomach-brain coupling in humans | [
"Ngo, T. T. T.",
"Hsu, T.-Y.",
"Duncan, N. W."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720086v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The connection between the digestive system and the brain is a topic of increasing interest. A burgeoning literature is elucidating how these organ systems interact and how these interactions can influence ... |
biorxiv | 10.64898/2026.04.22.720070 | 10.64898/2026.04.22.720070 | 2 | Bridging spatial scales in respiratory viral infection | [
"Hvid, U.",
"Nielsen, B. F.",
"Sneppen, K."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720070v2 | 2026-04-24T00:00:00 | [
{
"type": "para",
"text": "During viral infection of the respiratory system, successful viral reproduction depends on the availability of cells that are 1) not already infected and 2) susceptible to infection. If a virion is released in an area of the lung with a high concentration of viruses and where, per... |
biorxiv | 10.64898/2026.04.22.720067 | 10.64898/2026.04.22.720067 | 1 | hnRNPA2B1 Modulates Early TIA1 Recruitment into Stress Granules through an RNA-Dependent Assembly Mechanism | [
"Teshirogi, Y.",
"Mihara, R.",
"Saito, Y.",
"Rhee, H.-W.",
"Terada, T.",
"Tate, S.-i.",
"Kyota, Y."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720067v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Stress granules (SGs) are cytoplasmic, membrane-less organelles that assemble when cells are exposed to environmental stress 1 , 2 . Their formation is initiated by the phase separation of RNA-binding prote... |
biorxiv | 10.64898/2026.04.22.720063 | 10.64898/2026.04.22.720063 | 1 | GenNA: Conditional generation of nucleotide sequences guided by natural-language annotations | [
"Shen, Y.",
"Cao, G.",
"Wu, J.",
"Chen, D.",
"Feng, C.",
"Chen, M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720063v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Main"
},
{
"type": "para",
"text": "Understanding how nucleotide sequences encode complex biological functions has long been a central question in genomics and synthetic biology 1 . In recent years, the rapid development of foundation models for prot... |
biorxiv | 10.64898/2026.04.22.720059 | 10.64898/2026.04.22.720059 | 1 | Identification of tail-binding proteins of Arabidopsis class VIII myosin ATM1 using TurboID proximity labeling and AlphaFold3 | [
"Nagata, S.",
"Sakuraba, S.",
"Mishiro-Sato, E.",
"Shimada, T. L.",
"Oe, Y.",
"Tachibana, K.",
"Obara, J.",
"Tominaga, M.",
"Ito, K.",
"Haraguchi, T."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720059v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Myosin is a motor protein that converts chemical energy liberated by ATP hydrolysis into directed movement on actin filaments. Phylogenetic analyses of myosin motor domain sequences have identified at least... |
biorxiv | 10.64898/2026.04.22.720051 | 10.64898/2026.04.22.720051 | 1 | Normobaric hypoxia alters the transcriptional response of healthy human skeletal muscles to a single session of high-intensity interval exercise | [
"Li, J.",
"Taylor, D. F.",
"Kuang, J.",
"Wang, Z.",
"Zare, N.",
"Atakan, M. M.",
"Cui, K.",
"Ouzhu, N.",
"Bianba, B.",
"Garnham, A.",
"Lin, W.",
"Peng, L.",
"Girard, O.",
"Bishop, D. J.",
"Li, Y.",
"Yan, X."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720051v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Exercise is a potent non-pharmacological intervention that induces numerous health benefits 1 . By adjusting variables such as exercise intensity, duration, and modality, specific molecular and physiologica... |
biorxiv | 10.64898/2026.04.22.720035 | 10.64898/2026.04.22.720035 | 1 | Bacteriocin Diversity and Antiviral Potential of Lactiplantibacillus pentosus from Fermented Rice. | [
"Cheruvari, A.",
"kammara, R."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720035v1 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Traditional fermented foods represent one of the oldest and most cost-effective methods of food preservation, valued for their nutritional richness and probiotic content, including lactic acid bacteria (LAB... |
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