id stringlengths 6 42 | title stringlengths 3 499 | abstract stringlengths 0 6.24k | label listlengths 0 6 |
|---|---|---|---|
10.1371/journal.pone.0134219 | Microbial ligand costimulation drives neutrophilic steroid-refractory asthma | Asthma is a heterogeneous disease whose etiology is poorly understood but is likely to involve innate responses to inhaled microbial components that are found in allergens. The influence of these components on pulmonary inflammation has been largely studied in the context of individual agonists, despite knowledge that ... | [
"Immunity, Infection and Immunotherapy",
"Physiology in Health, Disease and Ageing"
] |
10.1159/000459635 | Early Programming Of Obesity Throughout The Life Course A Metabolomics Perspective | Background: Over the last decades, research on early life risk factors for obesity and its comorbidities in early life has gained attention within the field of de | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Physiology in Health, Disease and Ageing",
"Integrative Biology: from Genes and Genomes to Systems"
] |
10.1214/14-AAP1048 | Optimal Scaling For The Transient Phase Of The Random Walk Metropolis Algorithm The Mean Field Limit | We consider the random walk Metropolis algorithm on $\mathbb{R}^{n}$ with Gaussian proposals, and when the target probability measure is the $n$-fold product of a one-dimensional law. In the limit $n\to\infty$, it is well known (see [ Ann. Appl. Probab. 7 (1997) 110–120]) that, when the variance of the proposal scales ... | [
"Mathematics",
"Computer Science and Informatics"
] |
10.1039/C1CC11985K | Reversible Pressure Induced Amorphization Of A Zeolitic Imidazolate Framework Zif 4 | We report the reversible pressure-induced amorphization of a zeolitic imidazolate framework (ZIF-4, [Zn(Im)2]). This occurs irrespective of pore occupancy and takes place via a novel high pressure phase (ZIF-4-I) when solvent molecules are present in the pores. A significant reduction in bulk modulus upon framework eva... | [
"Condensed Matter Physics",
"Physical and Analytical Chemical Sciences",
"Synthetic Chemistry and Materials"
] |
10.1038/s41467-017-01374-x | High-frequency recombination between members of an LTR retrotransposon family during transposition bursts | Retrotransposons containing long terminal repeats (LTRs) form a substantial fraction of eukaryotic genomes. The timing of past transposition can be estimated by quantifying the accumulation of mutations in initially identical LTRs. This way, retrotransposons are divided into young, potentially mobile elements, and old ... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Integrative Biology: from Genes and Genomes to Systems"
] |
10.1021/nl502837d | Friction of water on graphene and hexagonal boron nitride from Ab initio methods: Very different slippage despite very similar interface structures | Friction is one of the main sources of dissipation at liquid water/solid interfaces. Despite recent progress, a detailed understanding of water/solid friction in connection with the structure and energetics of the solid surface is lacking. Here, we show for the first time that ab initio molecular dynamics can be used t... | [
"Condensed Matter Physics",
"Physical and Analytical Chemical Sciences"
] |
W1823605548 | Synergistic effects of geographical strain, temperature and larval food on insecticide tolerance in Callosobruchus maculatus (F.) | This study investigated the multifactorial interaction of various environmental factors including geographical strain (Brazil, Cameroon and Yemen strains), temperature, dose and larval food (cowpea and mungbean) on the response of Callosobruchus maculatus adult to insecticide. All the main factors, their two-way intera... | [
"Environmental Biology, Ecology and Evolution",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Biotechnology and Biosystems Engineering"
] |
US 2019/0038462 W | METHODS AND APPARATUSES FOR PROVIDING INPUT FOR HEAD-WORN IMAGE DISPLAY DEVICES | An apparatus for use with an image display device configured for head-worn by a user, includes: a screen; and a processing unit configured to assign a first area of the screen to sense finger-action of the user; wherein the processing unit is configured to generate an electronic signal to cause a change in a content di... | [
"Systems and Communication Engineering",
"Computer Science and Informatics"
] |
10.1039/c8sm02157k | A stochastic model for bacteria-driven micro-swimmers | We derive analytical expressions for the diffusion coefficient and the chemotactic drift velocity of bacteria-driven micro-swimmers. | [
"Mathematics",
"Physical and Analytical Chemical Sciences"
] |
10.1109/JPROC.2016.2597152 | Spintronic Nanodevices For Bioinspired Computing | Bioinspired hardware holds the promise of low-energy, intelligent, and highly adaptable computing systems. Applications span from automatic classification for big data management, through unmanned vehicle control, to control for biomedical prosthesis. However, one of the major challenges of fabricating bioinspired hard... | [
"Condensed Matter Physics",
"Computer Science and Informatics",
"Materials Engineering"
] |
184637 | Savanna water and carbon fluxes modelling integrating earth observation data | The aim of SWATCH is to develop a unique information system for quantifying savanna water use and biomass production on a regional scale, with the ultimate objective of supporting decision-making processes. This effort directly addresses the European H2020 priorities of sustainable rural development and food security. ... | [
"Earth System Science",
"Environmental Biology, Ecology and Evolution",
"Computer Science and Informatics",
"Systems and Communication Engineering"
] |
10.1371/journal.pgen.1008905 | Active transcription and Orc1 drive chromatin association of the AAA+ ATPase Pch2 during meiotic G2/prophase | Pch2 is an AAA+ protein that controls DNA break formation, recombination and checkpoint signaling during meiotic G2/prophase. Chromosomal association of Pch2 is linked to these processes, and several factors influence the association of Pch2 to euchromatin and the specialized chromatin of the ribosomal (r)DNA array of ... | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
312458 | LANGUAGE–PHILOLOGY–CULTURE: Arab Cultural Semantics in Transition | This project aims to study:
• the semantic development of the vocabulary of the Arabic language,
• philological discourses on the semantic changes in the language in the classical Arabic philological tradition (8th-10th centuries A.D.), and
• the impact of Arabic philology in the wider historical and cultural context o... | [
"Texts and Concepts",
"The Study of the Human Past",
"Studies of Cultures and Arts"
] |
10.1242/jcs.162305 | CRL4RBBP7 is required for efficient CENP-A deposition at centromeres | The mitotic spindle drives chromosome movement during mitosis and attaches to chromosomes at dedicated genomic loci named centromeres. Centromeres are epigenetically specified by their histone composition with the presence of the histone H3 variant CENP-A, which is regulated during the cell cycle by its dynamic express... | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
10.1515/opth-2019-0004 | Spatial analysis of new testament textual emendations utilizing confusion distances | Before the interpretation of any text can start, the original wording of the text itself must be critically established. Conventionally, this is done following qualitative criteria. This article, however, explores the application of spatial analyses to New Testament textual criticism by demonstrating how the Levenshtei... | [
"Computer Science and Informatics",
"Texts and Concepts"
] |
10.1145/2714566 | A Survey On Low Power Techniques With Emerging Technologies From Devices To Systems | Nowadays, power consumption is one of the main limitations of electronic systems. In this context, novel and emerging devices provide new opportunities to extend the trend toward low-power design. In this survey article, we present a transversal survey on energy-efficient techniques ranging from devices to architecture... | [
"Computer Science and Informatics",
"Systems and Communication Engineering"
] |
10.1117/12.2289859 | Ge Rich Sige Photonic Integrated Circuits For Mid Ir Spectroscopy | Recent works towards the development of Ge-rich SiGe photonic integrated circuits will be presented, such as the demonstration of low-loss waveguides and ultra-wideband Mach Zehnder interferometer from 5. 5 to 8. 6 μm wavelength, as well as the first steps towards the realization of efficient wideband optical sources. | [
"Physical and Analytical Chemical Sciences",
"Systems and Communication Engineering"
] |
GB 0226786 A | Water deflector for decking | A deck 6, attached to a wall 1 of a building, comprises a plurality of boards 6 mounted onto a framework 2, 5 fixed 3 to the wall, and including an elongate member 7 attached to the upper surface of the deck and adjacent the wall so as to deflect water, especially rain water 10, from the wall. The member 7 is preferabl... | [
"Products and Processes Engineering",
"Materials Engineering"
] |
10.1007/s10851-016-0641-0 | Locally Adaptive Frames in the Roto-Translation Group and Their Applications in Medical Imaging | Locally adaptive differential frames (gauge frames) are a well-known effective tool in image analysis, used in differential invariants and PDE-flows. However, at complex structures such as crossings or junctions, these frames are not well defined. Therefore, we generalize the notion of gauge frames on images to gauge f... | [
"Mathematics",
"Computer Science and Informatics"
] |
Q6725547 | Implementation of an innovative product in the form of a smart fibre switch on the market. | The product that will be created during the implementation of the project will be an intelligent switch with a controller and software for passporting fiber optic networks, detecting ports and detecting failure sites. The product technically and functionally has the characteristics of product innovation. The product by... | [
"Products and Processes Engineering",
"Systems and Communication Engineering"
] |
EP 2018051646 W | PROCESS FOR FORMING SHAPED ARTICLES COMPRISING CARBON NANOTUBES | A process for manufacturing shaped articles comprising carbon nanotubes comprising the steps of supplying carbon nanotubes in an acidic liquid comprising at least one acid, the at least one acid having a Hammett acidity function less than that of 100% sulfuric acid, the at least one acid having a Hammett acidity functi... | [
"Materials Engineering",
"Synthetic Chemistry and Materials"
] |
W2372473666 | On the physico-chemical monitoring and evaluation of the water environment for lenok and burbot aquatic germplasm resources of Pangu River reserve,Heilongjiang,China | The article takes it as its target to report its authors'investigation and physico-chemical monitoring and evaluation results of the water environment situation for lenok and burbot aquatic germplasm resources of Pangu River reserve, Heilongjiang, China. As is known, the natural reserve of Pangu River aquatic germplasm... | [
"Earth System Science",
"Environmental Biology, Ecology and Evolution",
"Physical and Analytical Chemical Sciences"
] |
10.1109/EMBC.2014.6944568 | Closed Form Solution Of The Convolution Integral In The Magnetic Resonance Dispersion Model For Quantitative Assessment Of Angiogenesis | Prostate cancer (PCa) diagnosis and treatment is still limited due to the lack of reliable imaging methods for cancer localization. Based on the fundamental role played by angiogenesis in cancer growth and development, several dynamic contrast enhanced (DCE) imaging methods have been developed to probe tumor angiogenic... | [
"Prevention, Diagnosis and Treatment of Human Diseases",
"Physical and Analytical Chemical Sciences",
"Mathematics"
] |
10.3847/1538-4357/ab1d4a | The Case of H<inf>2</inf>C<inf>3</inf>O Isomers, Revisited: Solving the Mystery of the Missing Propadienone | To date, two isomers of H2C3O have been detected, namely, propynal (HCCCHO) and cylclopropenone (c-H2C3O). A third, propadienone (CH2CCO), has thus far eluded observers despite the fact that it is the lowest in energy of the three. This previously noted result is in contradiction to the minimum energy principle, which ... | [
"Physical and Analytical Chemical Sciences",
"Universe Sciences"
] |
10.5194/cp-13-1049-2017 | The C<sub>32</sub> alkane-1,15-diol as a proxy of late Quaternary riverine input in coastal margins | . The study of past sedimentary records from coastal margins allows us to reconstruct variations in terrestrial input into the marine realm and to gain insight into continental climatic variability. There are numerous organic proxies for tracing terrestrial input into marine environments but none that strictly reflect ... | [
"Earth System Science"
] |
10.1093/beheco/art091 | An evolutionary approach to change of status-fertility relationship in human fertility transition | The change in benefits of high socioeconomic status to fertility in humans during the demographic transition from high to low fertility has interested both demographers and evolutionary biologists. Evolutionary analyses add to demographic analyses by considering also males and status-related differential in male mating... | [
"Environmental Biology, Ecology and Evolution",
"Human Mobility, Environment, and Space"
] |
10.1021/acsmacrolett.5b00608 | Amphiphilic Polymer Conetworks Based on End-Linked "core-First" Star Block Copolymers: Structure Formation with Long-Range Order | Amphiphilic polymer conetworks are cross-linked polymers that swell both in water and in organic solvents and can phase separate on the nanoscale in the bulk or in selective solvents. To date, however, this phase separation has only been reported with short-range order, characterized by disordered morphologies. We now ... | [
"Condensed Matter Physics",
"Materials Engineering"
] |
10.1098/rspb.2017.0335 | What shapes the continuum of reproductive isolation? Lessons from
Heliconius
butterflies | The process by which species evolve can be illuminated by investigating barriers that limit gene flow between taxa. Recent radiations, such as
Heliconius
butterflies, offer the opportunity to compare isolation between pairs of taxa at different stages of ecological, geographical, and phylogeneti... | [
"Environmental Biology, Ecology and Evolution",
"Integrative Biology: from Genes and Genomes to Systems"
] |
679186 | Foraging Decision Making in the Real World – revealed from a bat’s point of view by on-board miniature sensors | How animals make decisions in the wild is an open key-question in biology. Our lack of knowledge results from a technological gap – the difficulty to track animals over long periods while monitoring their behaviour; and from a conceptual gap – how to identify animals’ decision-points outdoors? We suggest applying our ... | [
"Environmental Biology, Ecology and Evolution",
"Biotechnology and Biosystems Engineering",
"Computer Science and Informatics"
] |
10.3389/fcell.2018.00100 | The Warburg effect in endothelial cells and its potential as an anti-angiogenic target in cancer | Endothelial cells (ECs) make up the lining of our blood vessels and they ensure optimal nutrient and oxygen delivery to the parenchymal tissue. In response to oxygen and/or nutrient deprivation, ECs become activated and sprout into hypo-vascularized tissues forming new vascular networks in a process termed angiogenesis... | [
"Physiology in Health, Disease and Ageing",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Cell Biology, Development, Stem Cells and Regeneration"
] |
10.5194/acp-19-4741-2019 | Cloud condensation nuclei activity of six pollenkitts and the influence of their surface activity | The role of surfactants in governing water interactions of atmospheric aerosols has been a recurring topic in cloud microphysics for more than two decades. Studies of detailed surface thermodynamics are limited by the availability of aerosol samples for experimental analysis and incomplete validation of various propose... | [
"Physical and Analytical Chemical Sciences",
"Earth System Science"
] |
W2002626578 | Metal pollution status in Zhelin Bay surface sediments inferred from a sequential extraction technique, South China Sea | Surface sediments collected from Zhelin Bay, the largest mariculture base of eastern Guangdong Province, were analyzed for total metal concentrations and chemical speciation. The results demonstrated that the average total concentration (mg/kg) ranges were 36.7-65.8 (Pb), 53.8-98.8 (Cr), 39.0-87.1 (Ni), 50.9-144.5 (Cu)... | [
"Physical and Analytical Chemical Sciences",
"Earth System Science"
] |
888538 | Development and application of hybrid joining in lightweight integral aircraft structures | The main objective of the DAHLIAS project is to optimise hybrid joining (Refill Friction Stir Spot Welding, RFSSW, with an adhesive sealant bond) for application in aircraft structures. RFSSW is a solid-state joining technology especially applicable to lightweight alloys in similar and dissimilar configurations. The pr... | [
"Products and Processes Engineering",
"Materials Engineering"
] |
W2916526362 | PIXE analysis of stream water following the Mt. Hakone eruption on 30 June 2015 — temporal changes in elemental concentrations over two years | After the 2011 Off the Pacific Coast of Tohoku Earthquake on 11 March, 2011, volcanic activity in Japan was observed to increase. In this study, we use the PIXE method to analyze elemental concentrations in stream water flowing directly from the fumarolic area on Mount Hakone, which erupted on 30 June 2015. Throughout ... | [
"Earth System Science",
"Physical and Analytical Chemical Sciences"
] |
W2122898505 | DEBT POLICY RULE, PRODUCTIVE GOVERNMENT SPENDING, AND MULTIPLE GROWTH PATHS: A NOTE | In a very interesting endogenous growth model, Futagami, Iwaisako, and Ohdoi [ Macroeconomic Dynamics 12 (2008), 445–462] study the long-run growth effect of borrowing for public investment. Their model exhibits (i) the multiplicity of balanced growth paths (BGPs) in the long run (two steady states) and (ii) a possible... | [
"Individuals, Markets and Organisations"
] |
10.3389/fcimb.2016.00152 | An in vitro co-culture mouse model demonstrates efficient vaccine-mediated control of Francisella tularensis SCHU S4 and identifies nitric oxide as a predictor of efficacy | Francisella tularensis is a highly virulent intracellular bacterium and cell-mediated immunity is critical for protection, but mechanisms of protection against highly virulent variants, such as the prototypic strain F. tularensis strain SCHU S4, are poorly understood. To this end, we established a co-culture system, b... | [
"Immunity, Infection and Immunotherapy",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
10.1002/biot.201500255 | Overcoming low yields of plant-made antibodies by a protein engineering approach | The commercial development of plant-based antibody production platforms is often limited by low and variable yields, but little is known about the factors that affect antibody accumulation during and after translation. Here, we present a strategy to identify yield-limiting regions in the transcript and protein. We exch... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Biotechnology and Biosystems Engineering"
] |
10.1016/j.cell.2013.05.014 | XOTULIN antagonizes LUBAC signaling by specifically hydrolyzing met1-linked polyubiquitin | The linear ubiquitin (Ub) chain assembly complex (LUBAC) is an E3 ligase that specifically assembles Met1-linked (also known as linear) Ub chains that regulate nuclear factor κB (NF-κB) signaling. Deubiquitinases (DUBs) are key regulators of Ub signaling, but a dedicated DUB for Met1 linkages has not been identified. H... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Integrative Biology: from Genes and Genomes to Systems"
] |
10.1007/978-3-319-96553-6_4 | Overview Of Geco A Project For Exploring And Integrating Signals From The Genome | Next Generation Sequencing is a 10-year old technology for reading the DNA, capable of producing massive amounts of genomic data - in turn, reshaping genomic computing. In particular, tertiary data analysis is concerned with the integration of heterogeneous regions of the genome; this is an emerging and increasingly im... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Integrative Biology: from Genes and Genomes to Systems"
] |
10.1002/ijc.30445 | A nonrandomized, prospective, clinical study on the impact of circulating tumor cells on outcomes of urothelial carcinoma of the bladder patients treated with radical cystectomy with or without adjuvant chemotherapy | To investigate outcomes of urothelial carcinoma of the bladder (UCB) patients treated with radical cystectomy (RC) according to the presence of circulating tumor cells (CTC) and the administration of adjuvant chemotherapy (AC). We prospectively enrolled 226 UCB patients treated with RC without neoadjuvant chemotherapy ... | [
"Physiology in Health, Disease and Ageing",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
174031 | Meet and learn what excellent science does for you and the society | Meet and learn What Excellent science does FOR YOU and the society is the major focus of the coordinated WeForYou action in performing the European Researchers’ Night 2014 and 2015 in Slovenia. Energy research & innovation, Environment & Climate Action, Health and ICT Research & Innovation are the priorities which will... | [
"Environmental Biology, Ecology and Evolution",
"Products and Processes Engineering",
"Prevention, Diagnosis and Treatment of Human Diseases",
"The Social World and Its Interactions"
] |
309848 | Innate sensing of HIV and immune responses | Since its isolation in 1983 as a causative agent of AIDS, HIV-1 has remained an exceptional challenge. The human immune system usually ultimately fails at controlling infection by the virus. In contrast, most individuals infected with the related and poorly studied lentivirus HIV-2 do not develop AIDS. The immune respo... | [
"Immunity, Infection and Immunotherapy",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
219589 | European frontiers: rural spaces and expanding states | Frontiers are dynamic zones of resistance and negotiation where local actors respond to the political/economic fluctuations of expanding states. Research on Europe’s frontier zones in the historic past has immediate relevance to the modern economic and political landscape, where the expansion of transnational markets i... | [
"The Study of the Human Past",
"Human Mobility, Environment, and Space",
"Computer Science and Informatics"
] |
227457 | Search for emergent phenomena in oxide nanostructures | Oxide nanostructures in low dimensions on well-defined metal surfaces form novel hybrid systems with tremendous potential and impact in fundamental research and for the emerging nanotechnologies. The focus of the project is on the fabrication of two-, quasi-one-, and quasi-zero-dimensional oxide nanostructure model sys... | [
"Condensed Matter Physics",
"Physical and Analytical Chemical Sciences",
"Synthetic Chemistry and Materials"
] |
10.1109/TBME.2013.2274816 | Modeling And Analysis Of Individualized Pharmacokinetics And Pharmacodynamics For Volatile Anesthesia | The presented procedure aims to establish an in-depth understanding of a derived mathematical model for drug distribution, pharmacokinetics, and drug effect, pharmacodynamics, during volatile anesthesia. A physiologically based, patient-specific model is derived, where the pharmacokinetic (PK) part consists of multiple... | [
"Physiology in Health, Disease and Ageing",
"Computer Science and Informatics",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
10.1111/sifp.12055 | The Stability Paradox: Why Expansion of Women's Education Has Not Delayed Early Union Formation or Childbearing in Latin America | Despite substantial improvements in women's education, the age at which Latin American women marry (cohabit) or become mothers for the first time has barely decreased over the past four decades. We refer to this as the “stability paradox. ” We examine the relationship between years of schooling and transitions to first... | [
"The Social World and Its Interactions",
"Human Mobility, Environment, and Space"
] |
10.1073/pnas.1600503113 | Bursts of activity in collective cell migration | Dense monolayers of living cells display intriguing relaxation dynamics, reminiscent of soft and glassy materials close to the jamming transition, and migrate collectively when space is available, as in wound healing or in cancer invasion. Here we show that collective cell migration occurs in bursts that are similar to... | [
"Condensed Matter Physics",
"Cell Biology, Development, Stem Cells and Regeneration"
] |
10.1016/j.jamda.2017.09.026 | The Prevalence and Correlates of Frailty in Urban and Rural Populations in Latin America, China, and India: A 10/66 Population-Based Survey | Background: There have been few cross-national studies of the prevalence of the frailty phenotype conducted among low or middle income countries. We aimed to study the variation in prevalence and correlates of frailty in rural and urban sites in Latin America, India, and China. Methods: Cross-sectional population-based... | [
"Physiology in Health, Disease and Ageing",
"Environmental Biology, Ecology and Evolution",
"Human Mobility, Environment, and Space"
] |
10.1016/j.cub.2014.10.042 | Asymmetric processing of visual motion for simultaneous object and background responses | Visual object fixation and figure-ground discrimination in Drosophila are robust behaviors requiring sophisticated computation by the visual system, yet the neural substrates remain unknown. Recent experiments in walking flies revealed object fixation behavior mediated by circuitry independent from the motion-sensitive... | [
"Neuroscience and Disorders of the Nervous System",
"Computer Science and Informatics"
] |
10.1146/annurev-pharmtox-010814-124511 | Synthetic lethal vulnerabilities of cancer | The great majority of targeted anticancer drugs inhibit mutated oncogenes that display increased activity. Yet many tumors do not contain such actionable aberrations, such as those harboring loss-of-function mutations. The notion of targeting synthetic lethal vulnerabilities in cancer cells has provided an alternative ... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Integrative Biology: from Genes and Genomes to Systems",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
W2019145052 | Establishment of a cell line from the brain of grouper (Epinephelus akaara) for cytotoxicity testing and virus pathogenesis | Abstract We established and characterized a continuous cell line (EAGB) from the brain of grouper (Epinephelus akaara). EAGB cells multiplied well in MEM that was supplemented with 10% fetal bovine serum at 30 °C. The EAGB cell line consisted predominantly of fibroblast-like cells from grouper, which was confirmed by t... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Cell Biology, Development, Stem Cells and Regeneration",
"Immunity, Infection and Immunotherapy"
] |
10.1073/pnas.1705165114 | Cancer cells induce interleukin-22 production from memory CD4+ T cells via interleukin-1 to promote tumor growth | IL-22 has been identified as a cancer-promoting cytokine that is secreted by infiltrating immune cells in several cancer models. We hypothesized that IL-22 regulation would occur at the interface between cancer cells and immune cells. Breast and lung cancer cells of murine and human origin induced IL-22 production from... | [
"Immunity, Infection and Immunotherapy",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
986720 | Adaptive and maladaptive endothelial cell dynamics during blood flow-driven vascular patterning | The formation of a functional patterned (adaptation) vascular network is essential for development, tissue growth, and organ physiology. Several human vascular disorders arise from the mis-patterning (maladaptation) of blood vessels, such as arteriovenous malformations, aneurysms, and diabetic retinopathy. Blood flow i... | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Physiology in Health, Disease and Ageing"
] |
896768 | Protect traditional built heritage skills – pro-heritage | According to the climate change and energy policy of the EU, each member state needed to identify and develop a series of energy efficient goals and regulations, of which buildings are a key element, in order to reach the set goals. However, Europe has numerous historic buildings, which need permanent maintenance and r... | [
"Earth System Science",
"Products and Processes Engineering"
] |
10.1002/lpor.201700226 | Stretchable Photonic ‘Fermi Arcs’ in Twisted Magnetized Plasma | Weyl points, three-dimensional linear bulk bands crossings possessing intrinsic helicities, are counterparts of magnetic monopoles in the momentum space. One of the most important features of Weyl semimetals is the presence of topologically protected non-trivial surface states at the boundary that connect between Weyl ... | [
"Fundamental Constituents of Matter",
"Condensed Matter Physics"
] |
W2800346076 | Time Headway analysis on urban roads of the city of Marrakesh | Abstract Vehicular Time Headway or Inter-arrival time is an important parameter in traffic flow theory. It has a major effect on traffic simulation especially in the traffic generation process. Most of the previous research on Time Headway modeling have focused on homogeneous traffic, on uninterrupted urban roads, free... | [
"Products and Processes Engineering",
"Systems and Communication Engineering"
] |
10.1088/0953-4075/43/21/213001 | High Order Harmonic And Attosecond Pulse Generation On Plasma Mirrors Basic Mechanisms | When an intense femtosecond laser pulse hits an optically polished surface, it generates a dense plasma that itself acts as a mirror, known as the plasma mirror. As this mirror reflects the high-intensity laser field, its nonlinear temporal response can lead to a periodic temporal distortion of the reflected wave, asso... | [
"Fundamental Constituents of Matter",
"Physical and Analytical Chemical Sciences"
] |
10.1038/s41590-018-0110-6 | Re-evaluating microglia expression profiles using RiboTag and cell isolation strategies /631/1647/2017 /631/1647/2017/2079 technical-report | Transcriptome profiling is widely used to infer functional states of specific cell types, as well as their responses to stimuli, to define contributions to physiology and pathophysiology. Focusing on microglia, the brain's macrophages, we report here a side-by-side comparison of classical cell-sorting-based transcripto... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Cell Biology, Development, Stem Cells and Regeneration",
"Neuroscience and Disorders of the Nervous System"
] |
W4281842343 | O PAPEL DO FARMACÊUTICO NA PANDEMIA DE COVID-19 | Em dezembro de 2019, na China, foram identificados casos de uma nova síndrome respiratória aguda, provocada por um novo coronavírus (2019-nCoV), que foi denominada COVID-19 (Coronavirus disease 2019). Devido ao agravamento rápido da doença, a situação foi dada como crítica, e os profissionais da saúde da linha de frent... | [
"Prevention, Diagnosis and Treatment of Human Diseases",
"The Social World and Its Interactions"
] |
10.1039/c8ee03423k | Powering sustainable development within planetary boundaries | Designing energy systems within planetary boundaries is crucial to preserving the Earth's ecological capacity given the power sector's environmental footprint. | [
"Earth System Science",
"Products and Processes Engineering"
] |
216393 | Remote-Activated delivery of therapeutic exosomes (radote) via an injectable peg hydrogel carrier | As a Marie Skłodowska-Curie Fellow, I will develop and demonstrate remote-activated delivery of biological therapeutics loaded into an injectable hydrogel, where delivery is triggered by applying near-infrared (NIR) light that safely and non-invasively penetrates deep into living tissues. The hydrogel carrier will be d... | [
"Materials Engineering",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Prevention, Diagnosis and Treatment of Human Diseases",
"Synthetic Chemistry and Materials",
"Cell Biology, Development, Stem Cells and Regeneration"
] |
757247 | Global data justice in the era of big data: toward an inclusive framing of informational rights and freedoms | The increasing adoption of digital technologies worldwide creates data flows from places and populations that were previously digitally invisible. The resulting ‘data revolution’ is hailed as a transformative tool for human and economic development. Yet the revolution is primarily a technical one: the power to monitor,... | [
"The Social World and Its Interactions",
"Institutions, Governance and Legal Systems",
"Computer Science and Informatics"
] |
10.1093/gbe/evs054 | The population genomics of a fast evolver: High levels of diversity, functional constraint, andmolecular adaptation in the tunicate Ciona intestinalis | Phylogenomics has revealed the existence of fast-evolving animal phyla in which the amino acid substitution rate, averaged across many proteins, is consistently higher than in other lineages. The reasons for such differences in proteome-wide evolutionary rates are still unknown, largely because only a handful of specie... | [
"Integrative Biology: from Genes and Genomes to Systems",
"Environmental Biology, Ecology and Evolution",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
10.1103/PhysRevX.7.021037 | Physical model of the genotype-to-phenotype map of proteins | How DNA is mapped to functional proteins is a basic question of living matter. We introduce and study a physical model of protein evolution which suggests a mechanical basis for this map. Many proteins rely on large-scale motion to function. We therefore treat protein as learning amorphous matter that evolves towards s... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Condensed Matter Physics",
"Integrative Biology: from Genes and Genomes to Systems"
] |
W2299480983 | Spillway discharges by modification of weir shapes and overflow surroundings | Almost all spillways of mid-size dams in Korea are overflow weir. To investigate the flood control capacity of overflow spillway, 3D numerical simulations were analyzed the discharge of a dam spillway for different weir shapes. Hydraulic model experiments, downsized as scale factor of 40 to 1 by Froude similitude were ... | [
"Products and Processes Engineering",
"Earth System Science"
] |
interreg_2707 | Polycentric Planning Models for Local Development in Territories interested by Corridor 5 and its TEN-T ramifications | The main problem addressed is the marginalization that a major transport infrastructure (MTI) can cause to alpine areas. The project aims at making mountain areas catch the opportunities of MTIs, rather than just suffer their environmental and social impact, targeting the phases of piloting and policy implementation.
T... | [
"Human Mobility, Environment, and Space",
"Institutions, Governance and Legal Systems",
"Earth System Science"
] |
10.1016/j.semcdb.2015.08.013 | Pax4 acts as a key player in pancreas development and plasticity | The embryonic development of the pancreas is orchestrated by a complex and coordinated transcription factor network. Neurogenin3 (Neurog3) initiates the endocrine program by activating the expression of additional transcription factors driving survival, proliferation, maturation and lineage allocation of endocrine prec... | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Physiology in Health, Disease and Ageing"
] |
10.1007/JHEP04(2015)172 | Excessive Higgs Pair Production With Little Met From Squarks And Gluinos In The Nmssm | In the presence of a light singlino-like LSP in the NMSSM, the missing transverse energy - MET - signature of squark/gluino production can be considerably reduced. Instead, a pair of Higgs bosons is produced in each event. We propose benchmark points for such scenarios, which differ in the squark and gluino masses, and... | [
"Fundamental Constituents of Matter",
"Computer Science and Informatics"
] |
interreg_3771 | The empress's route - Cultural and flavour itineraries between Veneto, Friuli and Slovenia | This initiative is going to carry out integrated actions to promote and enhance the cultural and historical traditions, and the typical productions of the whole Programme-area, in order to foster the development of tourism and of the other economic resources in the territory. The project aims at drawing an ideal line, ... | [
"Human Mobility, Environment, and Space",
"Studies of Cultures and Arts"
] |
171093 | Sperone speroni (1500-1588) and the rebirth of sophistry in the italian renaissance | This two-year research project aims to analyze the works of Sperone Speroni degli Alvarotti (Padua 1500–1588), his re-evaluation of ancient sophistic perspectives and his legacy in the early modern age. Speroni was one of the most important protagonists of the Renaissance debate on language and logic as well as civil a... | [
"Texts and Concepts",
"The Study of the Human Past"
] |
Q2054065 | SMART CHIAENZA | O OBJETIVO DA COMUNICAÇÃO É FACILITAR INVESTIMENTOS DESTINADOS A APOIAR A AQUISIÇÃO DE COMPETÊNCIAS POR EMPRESAS QUE PERMITAM O LANÇAMENTO E CONSOLIDAÇÃO DE UMA TRAJETÓRIA DE INOVAÇÃO, ATRAVÉS DE PROJETOS DE INVESTIMENTO EM PRODUTOS/SERVIÇOS, PROCESSOS, INOVAÇÃO ORGANIZACIONAL E COMERCIAL, TAMBÉM A SEREM IMPLEMENTADOS ... | [
"Products and Processes Engineering",
"Individuals, Markets and Organisations"
] |
W2005743391 | Silicon-based long-wavelength III–V quantum-dot lasers | The realization of electrically-pumped lasers on a Si platform will permit the creation of complex optoelectronic circuits, which will enable chip-to-chip and system-to-system optical communication. Direct epitaxial growth of III–V semiconductor materials on Si or Ge substrates is the most promising approach for produc... | [
"Condensed Matter Physics",
"Synthetic Chemistry and Materials",
"Systems and Communication Engineering",
"Materials Engineering"
] |
10.1111/1567-1364.12196 | The Yeast Oligopeptide Transporter Opt2 Is Localized To Peroxisomes And Affects Glutathione Redox Homeostasis | Glutathione, the most abundant small-molecule thiol in eukaryotic cells, is synthesized de novo solely in the cytosol and must subsequently be transported to other cellular compartments. The mechanisms of glutathione transport into and out of organelles remain largely unclear. We show that budding yeast Opt2, a close h... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Cell Biology, Development, Stem Cells and Regeneration"
] |
10.1007/s10071-011-0391-8 | Spatial cognition in zebrafish: The role of strain and rearing environment | Two strains of zebrafish, WIK and a second-generation wild strain were reared in either a structurally simple or complex environment and compared in their ability to locate a food reward in a five-chambered maze. There was a significant interaction within subjects between rearing environment and trial, indicating that ... | [
"Neuroscience and Disorders of the Nervous System",
"Environmental Biology, Ecology and Evolution"
] |
10.1007/s00018-018-2789-9 | Challenges and approaches to understand cholesterol-binding impact on membrane protein function: an NMR view | Experimental evidence for a direct role of lipids in determining the structure, dynamics, and function of membrane proteins leads to the term ‘functional lipids’. In particular, the sterol molecule cholesterol modulates the activity of many membrane proteins. The precise nature of cholesterol-binding sites and the cons... | [
"Physical and Analytical Chemical Sciences",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
W1987473619 | Formation of black carbon-like and alicyclic aliphatic compounds by hydroxyl radical initiated degradation of lignin | Abstract Exposure of lignin-derived organic matter (OM) to hydroxyl radicals originating from Fenton type reactions generates condensed aromatic and alicyclic aliphatic compounds, as shown using ultrahigh resolution mass spectrometry. Although condensed aromatic compounds are common in soil and dissolved OM, their pres... | [
"Physical and Analytical Chemical Sciences",
"Earth System Science"
] |
10.3791/52770 | Hybrid Μct Fmt Imaging And Image Analysis | Fluorescence-mediated tomography (FMT) enables longitudinal and quantitative determination of the fluorescence distribution in vivo and can be used to assess the biodistribution of novel probes and to assess disease progression using established molecular probes or reporter genes. The combination with an anatomical mod... | [
"Prevention, Diagnosis and Treatment of Human Diseases",
"Physical and Analytical Chemical Sciences",
"Computer Science and Informatics"
] |
W2013331954 | Instantaneous model adaptation method for reverberant speech recognition | An acoustic model adaptation algorithm is proposed for reverberant speech recognition. Inspired by the eigenvoice adaptation framework, multiple acoustic models reflecting various reverberant environments are combined for instantaneous adaptation. Using artificially generated reverberant speech, multiple acoustic model... | [
"Computer Science and Informatics",
"Systems and Communication Engineering"
] |
10.1109/JPHOT.2015.2446203 | Multiuser Miso Transceiver Design For Indoor Downlink Visible Light Communication Under Per Led Optical Power Constraints | Light-emitting diode (LED)-based visible light communication (VLC), combining illumination and communication, is a promising technique for providing high-speed, low-cost indoor wireless services. In indoor environments, multiple LEDs routinely used as lighting sources may also be concomitantly invoked to support wirele... | [
"Systems and Communication Engineering",
"Physical and Analytical Chemical Sciences"
] |
10.1103/PhysRevB.98.085302 | Coupled wire model of Z4 orbifold quantum Hall states | We introduce a coupled wire model for a sequence of non-Abelian quantum Hall states that generalize the Z4 parafermion Read-Rezayi state. The Z4 orbifold quantum Hall states occur at filling factors ν=2/(2m-p) for odd integers m and p, and have a topological order with a neutral sector characterized by the orbifold con... | [
"Condensed Matter Physics",
"Mathematics"
] |
W2979982423 | VDJbase: an adaptive immune receptor genotype and haplotype database | Abstract VDJbase is a publicly available database that offers easy searching of data describing the complete sets of gene sequences (genotypes and haplotypes) inferred from adaptive immune receptor repertoire sequencing datasets. VDJbase is designed to act as a resource that will allow the scientific community to explo... | [
"Immunity, Infection and Immunotherapy",
"Integrative Biology: from Genes and Genomes to Systems",
"Computer Science and Informatics"
] |
10.1161/JAHA.115.002681 | Diastolic Left Ventricular Function In Relation To Circulating Metabolic Biomarkers In A General Population | Background The metabolic signature associated with subclinical diastolic left ventricular (LV) dysfunction in the population remains ill defined. Methods and Results In 711 randomly recruited Flemish (50. 8% women; mean age, 50. 8 years), we assessed echocardiographic Doppler indexes of diastolic LV function in relatio... | [
"Physiology in Health, Disease and Ageing",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
2726329 | Developing and implementing sustainability-based solutions for bio-based plastic production and use to preserve land and sea environmental quality in europe | The project BIO-PLASTICS EUROPE addresses the topic „Sustainable solutions for bio-based plastics on land and sea“ (Topic identifier: CE-BG-06-2019), within the focus area „Connecting economic and environmental gains - the Circular Econonmy (CE)“ and will focus on sustainability strategies and solutions for bio-based p... | [
"Products and Processes Engineering",
"Environmental Biology, Ecology and Evolution",
"Biotechnology and Biosystems Engineering"
] |
W2084716952 | Bayesian Disease Classification Using Copy Number Data | DNA copy number variations (CNVs) have been shown to be associated with cancer development and progression. The detection of these CNVs has the potential to impact the basic knowledge and treatment of many types of cancers, and can play a role in the discovery and development of molecular-based personalized cancer ther... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Integrative Biology: from Genes and Genomes to Systems",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
10.1111/1746-8361.12043 | Accuracy And Evidence | In "A Nonpragmatic Vindication of Probabilism", Jim Joyce argues that our credences should obey the axioms of the probability calculus by showing that, if they don't, there will be alternative credences that are guaranteed to be more accurate than ours. But it seems that accuracy is not the only goal of credences: ther... | [
"Texts and Concepts",
"The Human Mind and Its Complexity"
] |
10.1016/j.molcel.2015.03.027 | Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed | Circular RNAs (circRNAs) are an endogenous class of animal RNAs. Despite their abundance, their function and expression in the nervous system are unknown. Therefore, we sequenced RNA from different brain regions, primary neurons, isolated synapses, as well as during neuronal differentiation. Using these and other avail... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Neuroscience and Disorders of the Nervous System",
"Integrative Biology: from Genes and Genomes to Systems"
] |
10.1371/journal.pone.0041921 | Dynamic expression of the translational machinery during Bacillus subtilis life cycle at a single cell level | The ability of bacteria to responsively regulate the expression of translation components is crucial for rapid adaptation to fluctuating environments. Utilizing Bacillus subtilis (B. subtilis) as a model organism, we followed the dynamics of the translational machinery at a single cell resolution during growth and dif... | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
725085 | Chemical proteome mining for functional annotation of disease relevant proteins | Genome sequencing projects have provided unique insights into the cellular inventory of genes and their corresponding protein products. Despite this success, a large fraction of cellular proteins remains functionally uncharacterized. Their annotation represents a major challenge for contemporary research, reaching beyo... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Physical and Analytical Chemical Sciences",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
W2056378745 | Lie Algebras with a Coalgebra Splitting | In their recent article [5], the authors endow every finite-dimensional simple complex Lie algebra g with a coalgebra structure such that the composition μ◦δ of the two structure maps δ : g −→ g⊗Cg and μ : g⊗C g −→ g coincides with the identity. Moreover, the dual algebra (g∗, δ∗) associated to the Lie coalgebra is iso... | [
"Mathematics"
] |
10.1523/JNEUROSCI.3456-16.2017 | Selective Silencing Of Hippocampal Parvalbumin Interneurons Induces Development Of Recurrent Spontaneous Limbic Seizures In Mice | Temporal lobe epilepsy (TLE) is the most frequent form of focal epilepsies and is generally associated with malfunctioning of the hippocampal formation. Recently, a preferential loss of parvalbumin (PV) neurons has been observed in the subiculum of TLE patients and in animal models of TLE. To demonstrate a possible cau... | [
"Neuroscience and Disorders of the Nervous System",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Physiology in Health, Disease and Ageing"
] |
10.1038/ncomms4221 | Strong schottky barrier reduction at au-catalyst/gaas-nanowire interfaces by electric dipole formation and fermi-level unpinning | Nanoscale contacts between metals and semiconductors are critical for further downscaling of electronic and optoelectronic devices. However, realizing nanocontacts poses significant challenges since conventional approaches to achieve ohmic contacts through Schottky barrier suppression are often inadequate. Here we repo... | [
"Condensed Matter Physics",
"Materials Engineering"
] |
10.1089/ast.2016.1557 | Evaluation of the Tindouf Basin Region in Southern Morocco as an Analogue Site for Soil Geochemistry on Noachian Mars | Locations on Earth that provide insights into processes that may be occurring or may have occurred throughout martian history are often broadly deemed "Mars analog environments. " As no single locale can precisely represent a past or present martian environment, it is important to focus on characterization of terrestri... | [
"Earth System Science",
"Universe Sciences"
] |
10.1038/s41556-018-0140-1 | Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells | BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. To understand the resistance mechanisms, we conducted whole-genome CRISPR–Cas9 synthetic-viability/resistance screens in BRCA1-deficient breast cancer cells treated w... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Integrative Biology: from Genes and Genomes to Systems",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
EP 2013055679 W | COMPATIBILITY CONTROL OF COMPONENTS CONNECTED TO WORK MACHINE | The present invention relates to a method for controlling compatibility of components connected to a work machine comprising a control system. A compatibility check request message is transmitted to a server in response to detecting that identification information of a component attached to the work machine is unknown.... | [
"Systems and Communication Engineering",
"Computer Science and Informatics"
] |
10.1093/cercor/bhy330 | Waves of maturation and senescence in micro-structural MRI markers of human cortical myelination over the lifespan | Seminal human brain histology work has demonstrated developmental waves of myelination. Here, using a micro-structural magnetic resonance imaging (MRI) marker linked to myelin, we studied fine-grained age differences to deduce waves of growth, stability, and decline of cortical myelination over the life-cycle. In 484 p... | [
"Neuroscience and Disorders of the Nervous System",
"Physiology in Health, Disease and Ageing"
] |
622627 | Improving the preparedness of health systems to reduce mental health and psychosocial concerns resulting from the covid-19 pandemic | The mission of RESPOND is 1) to identify critical resilience factors and specific vulnerable groups at risk of immediate and long-term adverse mental health impact of the COVID-19 pandemic; 2) To improve the resilience, wellbeing and mental health of frontline health and care workers and other vulnerable groups by impl... | [
"Prevention, Diagnosis and Treatment of Human Diseases",
"The Human Mind and Its Complexity",
"Institutions, Governance and Legal Systems"
] |
819627 | Beyond Light Imaging: High-Rate Single-Photon Detection in Four Dimensions | Goal of the 4DPHOTON project is the development and construction of a photon imaging detector with unprecedented performance. The proposed device will be capable of detecting fluxes of single-photons up to one billion photons per second, over areas of several square centimetres, and will measure - for each photon - pos... | [
"Fundamental Constituents of Matter",
"Systems and Communication Engineering"
] |
10.1080/14686996.2016.1244474 | A Study Of The Optical And Polarisation Properties Of Ingan Gan Multiple Quantum Wells Grown On A Plane And M Plane Gan Substrates | In this paper we report on a comparative study of the low temperature emission and polarisation properties of InGaN/GaN quantum wells (QWs) grown on nonpolar a-plane and m-plane free-standing bulk GaN substrates where the In content varied from 0. 14 to 0. 28 in the m-plane series and 0. 08 to 0. 21 for the a-plane ser... | [
"Condensed Matter Physics",
"Physical and Analytical Chemical Sciences",
"Synthetic Chemistry and Materials"
] |
10.1016/j.bbabio.2015.08.007 | The origin of the unusual Q<inf>y</inf> red shift in LH1-RC complexes from purple bacteria Thermochromatium tepidum as revealed by Stark absorption spectroscopy | Native LH1-RC of photosynthetic purple bacteria Thermochromatium (Tch. ) tepidum, B915, has an ultra-red BChl a Qy absorption. Two blue-shifted complexes obtained by chemical modification, B893 and B882, have increasing full widths at half maximum (FWHM) and decreasing transition dipole oscillator strength. 77 K Stark ... | [
"Physical and Analytical Chemical Sciences",
"Condensed Matter Physics"
] |
W1966174625 | Quantitative assessment of the diagnostic role of human telomerase activity from pancreatic juice in pancreatic cancer | Many studies have shown that human telomerase activity could play potential role as a diagnostic biomarker of pancreatic cancer (PaC). The aim of this meta-analysis is to summarize the clinical value of human telomerase activity in the diagnosis of PaC. Eligible studies from PubMed, Embase, the Cochrane Library, Web of... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
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