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10.1002/1873-3468.13067
Regulation Of Primary Microrna Processing
MicroRNAs (miRNAs) are evolutionarily conserved small regulatory RNAs that participate in the adjustment of many, if not all, fundamental biological processes. Molecular mechanisms involved in miRNA biogenesis and mode of action have been elucidated in the past two decades. Similar to many cellular pathways, miRNA proc...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems" ]
247208
Quantum optics with microwave photons building a tool-box based on superconducting technology
The research proposed in this application has grown out of the research on solid-state qubits, where a superconducting circuit including Josephson junctions can be made into a quantum-coherent, two-level system, an artificial atom. It has recently been shown that these artificial atoms can be integrated with microwave ...
[ "Condensed Matter Physics", "Fundamental Constituents of Matter", "Systems and Communication Engineering" ]
10.1007/978-3-319-00128-9
Hypoelliptic Laplacian and Bott-Chern cohomology: A theorem of Riemann-Roch-Grothendieck in complex geometry
The book provides the proof of a complex geometric version of a well-known result in algebraic geometry: the theorem of Riemann-Roch-Grothendieck for proper submersions. It gives an equality of cohomology classes in Bott-Chern cohomology, which is a refinement for complex manifolds of de Rham cohomology. When the manif...
[ "Mathematics" ]
FR 2019052993 W
UNDERWIRED BRA AND GARMENT, IN PARTICULAR LINGERIE ITEM HAVING SUCH A BRA
- Underwired bra and garment, in particular lingerie item having such a bra. - The bra (1) comprises at least two cups (4, 5) and two curved underwires (6, 7), each of the underwires (6, 7) being associated with one of the cups (4, 5), each of the underwires (6, 7) having a so-called joining end (6B, 7B) and a so-calle...
[ "Products and Processes Engineering", "Materials Engineering" ]
10.1016/j.cognition.2013.11.013
Processing inferences at the semantics/pragmatics frontier: Disjunctions and free choice
Linguistic inferences have traditionally been studied and categorized in several categories, such as entailments, implicatures or presuppositions. This typology is mostly based on traditional linguistic means, such as introspective judgments about phrases occurring in different constructions, in different conversationa...
[ "The Human Mind and Its Complexity", "Texts and Concepts" ]
10.1039/c9mh01020c
The role of traps in the photocurrent generation mechanism in thin InSe photodetectors
Due to the excellent electrical transport properties and optoelectronic performance, thin indium selenide (InSe) has recently attracted attention in the field of 2D semiconducting materials.
[ "Condensed Matter Physics", "Materials Engineering", "Synthetic Chemistry and Materials" ]
10.1088/1748-9326/ab7397
Focus on leakage and spillovers: Informing land-use governance in a tele-coupled world
Governing land use to achieve sustainable outcomes is challenging, because land systems manifest complex land use spillovers-i. e. processes by which land use changes or direct interventions in land use (e. g. policy, program, new technologies) in one place have impacts on land use in another place. The ERL issue 'Fo...
[ "Earth System Science", "Human Mobility, Environment, and Space", "Institutions, Governance and Legal Systems" ]
10.1084/jem.20180628
Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency
Life-threatening pulmonary influenza can be caused by inborn errors of type I and III IFN immunity. We report a 5-yr-old child with severe pulmonary influenza at 2 yr. She is homozygous for a loss-of-function IRF9 allele. Her cells activate gamma-activated factor (GAF) STAT1 homodimers but not IFN-stimulated gene fact...
[ "Immunity, Infection and Immunotherapy", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems" ]
Q3754332
Vattu — Virtual products of manufacturing industry
The aim of the project is to produce and implement new information for companies to utilise gaming engine technology in their production and operations through research, studies and experiments. In particular, the study will focus on the cost-effective translation of design models, i.e. 3D CADs, with the most automated...
[ "Products and Processes Engineering", "Computer Science and Informatics" ]
10.1007/JHEP03(2015)149
Black Rings In Global Anti De Sitter Space
We construct five dimensional black rings in global anti-de Sitter space using numerical methods. These rings satisfy the BPS bound |J| < Ml, but the angular velocity always violates the Hawking-Reall bound |Ω H l| ≤ 1, indicating that they should be unstable under superradiance. At high temperatures, the limit |Ω H...
[ "Fundamental Constituents of Matter", "Mathematics" ]
10.1088/0004-637X/788/1/13
The Light Curve Shapes As A Key To Resolving The Origin Of Long Secondary Periods In Red Giant Stars
We present a study of Optical Gravitational Lensing Experiment light curves of red giant stars exhibiting long secondary periods (LSPs)—an enigmatic phenomenon commonly observed in stars on the upper red giant branch and asymptotic giant branch. We show that the light curves of LSP stars are essentially identical to th...
[ "Universe Sciences" ]
10.1111/eulj.12230
European crises of legally-constituted public power: From the ‘law of corporatism’ to the ‘law of governance’
The ‘turn to corporatism’ in the interwar period implied an erosion of the fragile institutionalisation of legallyconstituted public power due to its suspension of the legal infrastructure of society and the concomitant breakdown of the distinction between the public and private realms of society. The dual (trans-)nati...
[ "Institutions, Governance and Legal Systems" ]
10.1039/C6RA26958C
Borophene Hydride A Stiff 2D Material With High Thermal Conductivity And Attractive Optical And Electronic Properties
Two-dimensional (2D) structures of boron atoms so called borophene, have recently attracted remarkable attention. In a latest exciting experimental study, a hydrogenated borophene structure was realized. Motivated by this success, we conducted extensive first-principles calculations to explore the mechanical, thermal c...
[ "Condensed Matter Physics", "Materials Engineering" ]
176784
Advanced distributed pilot line for more-than-moore technologies
The “Advanced Distributed Pilot Line for More-than-Moore Technologies” project (ADMONT) is focused on a powerful and versatile More-than-Moore (MtM) pilot line for Europe increasing the diversification of CMOS process technologies. The combination of existing expertise, technological capabilities and the manufacturing ...
[ "Products and Processes Engineering", "Systems and Communication Engineering", "Materials Engineering" ]
10.1109/ICASSP.2017.7951789
An Em Algorithm For Joint Source Separation And Diarisation Of Multichannel Convolutive Speech Mixtures
We present a probabilistic model for joint source separation and diarisation of multichannel convolutive speech mixtures. We build upon the framework of local Gaussian model (LGM) with non-negative matrix factorization (NMF). The diarisation is introduced as a temporal labeling of each source in the mix as active or in...
[ "Computer Science and Informatics", "Systems and Communication Engineering" ]
W1556051243
The Effects of the Financial Crisis on the Financial Performance of Malaysian Companies
The 2007/08 financial crisis which began in the United States was not felt in Malaysia until the last quarter of 2008 where GDP stalled and then began to fall. The country has a high export to GDP ratio and in 2009 the contraction in manufacturing exports was steep. This paper investigates the effects of the crisis on ...
[ "Individuals, Markets and Organisations" ]
10.1002/2015GC006019
Coupling Changes In Densities And Porosity To Fluid Pressure Variations In Reactive Porous Fluid Flow Local Thermodynamic Equilibrium
Mineralogical reactions which generate or consume fluids play a key role during fluid flow in porous media. Such reactions are linked to changes in density, porosity, permeability, and fluid pressure which influence fluid flow and rock deformation. To understand such a coupled system, equations were derived from mass c...
[ "Earth System Science", "Physical and Analytical Chemical Sciences" ]
204979
Hamiltonian Partial Differential Equations: new connections between dynamical systems and PDEs with small divisors phenomena
The aim of this project of 4 years is to create a research group on Hamiltonian Partial Differential Equations (PDEs) after my new arrival in the University Federico II of Naples as Associate Professor in november 2005. I plan to hire 2 post doc fellows and also to organize advanced research Schools and Workshops. I pl...
[ "Mathematics" ]
695646
Rules of self-organization and reengineering of liver tissue
We want to understand the rules of self-organization underlying tissue structure and function. To address this problem, we have chosen the mouse liver with its complex apico-basal polarity of hepatocytes and its unique 3D tissue organization. We aim at identifying the rules of self-organization of liver tissue and thei...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems", "Physiology in Health, Disease and Ageing" ]
10.1088/0004-637X/792/2/84
From Starburst To Quiescence Testing Active Galactic Nucleus Feedback In Rapidly Quenching Post Starburst Galaxies
Post-starbursts are galaxies in transition from the blue cloud to the red sequence. Although they are rare today, integrated over time they may be an important pathway to the red sequence. This work uses SDSS, GALEX, and WISE observations to identify the evolutionary sequence from starbursts to fully quenched post-star...
[ "Universe Sciences" ]
10.1080/15384101.2017.1417707
Mitochondrial Complex Iii Rieske Fe S Protein Processing And Assembly
Regulation of the mitochondrial respiratory chain biogenesis is a matter of great interest because of its implications for mitochondrial disease. One of the mitochondrial disease genes recently discovered associated to encephalopathy and mitochondrial complex III (cIII) deficiency is TTC19. Our study of TTC19-deficient...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Physiology in Health, Disease and Ageing" ]
240795
Cause of Death Contribution to Longevity: Modeling Time Trends
Since the mid-nineteen century life expectancy in developed countries has doubled, increasing from levels around 40 years to above 80 years. This research project is motivated by the need to further explore how societies have achieved the current levels of longevity, in terms of life expectancy and modal age at death. ...
[ "Earth System Science", "Human Mobility, Environment, and Space", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.2217/epi.14.13
Using epigenomic studies in monozygotic twins to improve our understanding of cancer
Cancer is a set of diseases that exhibit not only genetic mutations but also a profoundly distorted epigenetic landscape. Over the last two decades, great advances have been made in identifying these alterations and their importance in the initiation and progression of cancer. Epigenetic changes can be seen from the ve...
[ "Integrative Biology: from Genes and Genomes to Systems", "Physiology in Health, Disease and Ageing", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1111/jofi.12778
What Is the Expected Return on a Stock?
We derive a formula for the expected return on a stock in terms of the risk-neutral variance of the market and the stock's excess risk-neutral variance relative to that of the average stock. These quantities can be computed from index and stock option prices; the formula has no free parameters. The theory performs well...
[ "Individuals, Markets and Organisations", "Mathematics" ]
10.1371/journal.pone.0122129
Toddlers favor communicatively presented information over statistical reliability in learning about artifacts
Observed associations between events can be validated by statistical information of reliability or by testament of communicative sources. We tested whether toddlers learn from their own observation of efficiency, assessed by statistical information on reliability of interventions, or from communicatively presented demo...
[ "The Human Mind and Its Complexity" ]
10.29007/m8ts
The Triguarded Fragment of First-Order Logic
Past research into decidable fragments of first-order logic (FO) has produced two very prominent fragments: the guarded fragment GF, and the two-variable fragment FO2. These fragments are of crucial importance because they provide significant insights into decidabil- ity and expressiveness of other (computational) logi...
[ "Mathematics", "Computer Science and Informatics" ]
W2900367921
Introduction to the China-Vietnam Cooperation Project: A Comparative Study of the Holocene Sedimentary Evolution of the Yangtze and Red River Deltas
Both China and Vietnam confront the challenges of natural geohazards and environmental changes in their deltas and coastal zones due to rapid urbanization, economic development, and the impacts of global climate change. China and Vietnam initiated a comparative study of the Holocene sedimentary evolution of the Yangtze...
[ "Earth System Science", "Human Mobility, Environment, and Space" ]
interreg_1275
A cross-border project of environmental education 
The project aims at promoting cooperation among primary education institutes in the field of environmental education. These initiatives are geared towards a fuller understanding of the importance of waste recycling and selective waste collection. It is intended to raise awareness towards environmental issues and at the...
[ "Environmental Biology, Ecology and Evolution", "Human Mobility, Environment, and Space", "The Social World and Its Interactions" ]
W1514810249
Implementation of step sectioning in the examination of sentinel lymph nodes to improve the detection of micrometastases in breast cancer patients
The object of this study was to examine whether a new protocol for examination of sentinel lymph nodes (SLNs) would lead to the detection of more metastases. Sections of 1 mm would identify most SLN macrometastases, and step sections at intervals of 200-250 μm would identify most micrometastases. A total of 111 breast ...
[ "Prevention, Diagnosis and Treatment of Human Diseases", "Physiology in Health, Disease and Ageing" ]
10.1016/j.cell.2016.06.041
Human SRMAtlas: A Resource of Targeted Assays to Quantify the Complete Human Proteome
The ability to reliably and reproducibly measure any protein of the human proteome in any tissue or cell type would be transformative for understanding systems-level properties as well as specific pathways in physiology and disease. Here, we describe the generation and verification of a compendium of highly specific as...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Physical and Analytical Chemical Sciences", "Integrative Biology: from Genes and Genomes to Systems", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1109/MWC.2016.7498075
Large Scale Mimo Is Capable Of Eliminating Power Thirsty Channel Coding For Wireless Transmission Of Hevc H 265 Video
A wireless video transmission architecture relying on the emerging large-scale multiple-input--multiple-output (LS-MIMO) technique is proposed. Upon using the most advanced High Efficiency Video Coding (HEVC) (also known as H. 265), we demonstrate that the proposed architecture invoking the low-complexity linear zero-f...
[ "Systems and Communication Engineering", "Computer Science and Informatics" ]
10.1371/journal.pbio.1001824
Lowered Insulin Signalling Ameliorates Age-Related Sleep Fragmentation in Drosophila
Sleep fragmentation, particularly reduced and interrupted night sleep, impairs the quality of life of older people. Strikingly similar declines in sleep quality are seen during ageing in laboratory animals, including the fruit fly Drosophila. We investigated whether reduced activity of the nutrient- and stress-sensing ...
[ "Physiology in Health, Disease and Ageing", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems" ]
267234
Green Nanotechnology for the Indoor Environment
The GRINDOOR project aims at developing and implementing new materials that enable huge energy savings in buildings and improve the quality of the indoor environment. About 40% of the primary energy, and 70% of the electricity, is used in buildings, and therefore the outcome of this project can have an impact on the lo...
[ "Materials Engineering", "Condensed Matter Physics", "Physical and Analytical Chemical Sciences", "Synthetic Chemistry and Materials", "Products and Processes Engineering" ]
10.1097/JCP.0000000000000792
Hearts And Minds Real Life Cardiotoxicity With Clozapine In Psychosis
AbstractBackgroundSchizophrenia has a 1% prevalence in the population; 30% of these patients are treatment refractory. Clozapine is the only drug licensed to treat treatment refractory psychosis, but concerns about potential adverse effects result in only a proportion of eligible patients being trea
[ "Neuroscience and Disorders of the Nervous System", "Physiology in Health, Disease and Ageing" ]
10.1088/2041-8205/755/1/L22
Cyclic Magnetic Activity Due To Turbulent Convection In Spherical Wedge Geometry
We report on simulations of turbulent, rotating, stratified, magnetohydrodynamic convection in spherical wedge geometry. An initially small-scale, random, weak-amplitude magnetic field is amplified by several orders of magnitude in the course of the simulation to form oscillatory large-scale fields in the saturated sta...
[ "Universe Sciences", "Condensed Matter Physics" ]
10.5194/acp-11-4445-2011
Seasonal cycle, size dependencies, and source analyses of aerosol optical properties at the SMEAR II measurement station in Hyytiälä, Finland
Abstract. Scattering and absorption were measured at the Station for Measuring Ecosystem–Atmosphere Relations (SMEAR II) station in Hyytiälä, Finland, from October 2006 to May 2009. The average scattering coefficient σSP (λ = 550 nm) 18 Mm−1 was about twice as much as at the Pallas Global Atmosphere Watch (GAW) station...
[ "Physical and Analytical Chemical Sciences", "Earth System Science" ]
10.1007/978-3-030-56877-1_26
Nizk From Lpn And Trapdoor Hash Via Correlation Intractability For Approximable Relations
We present new non-interactive zero-knowledge argument systems (NIZK), based on standard assumptions that were previously not known to imply it. In particular, we rely on the hardness of both the learning parity with noise (LPN) assumption, and the existence of trapdoor hash functions (TDH, defined by Dottling et al. ,...
[ "Computer Science and Informatics", "Mathematics" ]
W2110150333
Theory of the scattering of light and surface plasmon polaritons by finite-size subwavelength metallic defects via field decomposition
A theoretical model is presented for the scattering of light and surface plasmon polaritons (SPPs) by finite-size subwavelength metallic defects. Based on the decomposition of the scattered fields into SPPs and quasi-cylindrical waves (CWs), an SPP–CW model is developed to depict the multiple scattering of SPPs and CWs...
[ "Physical and Analytical Chemical Sciences", "Condensed Matter Physics" ]
10.3847/0004-637X/831/1/91
Faint Submillimeter Galaxies Identified Through Their Optical Near Infrared Colors I Spatial Clustering And Halo Masses
The properties of submillimeter galaxies (SMGs) that are fainter than the confusion limit of blank-field single-dish surveys (S850  2 mJy) are poorly constrained. Using a newly developed color selection technique, Optical-Infrared Triple Color (OIRTC), that has been shown to successfully select such faint SMGs, we ide...
[ "Universe Sciences" ]
10.1109/ULTSYM.2014.0092
Non Linear Cavitation Cloud Oscillations In High Intensity Focused Ultrasound
Cavitation driven by high-intensity focused ultrasound is being investigated as a potential mechanism for therapeutic ultrasound. In this role, the mechanical bubble activity could be used for localised tissue disruption, facilitating targeted drug delivery. The cavitation sub-harmonic signal, which is emitted at sub-m...
[ "Condensed Matter Physics", "Physical and Analytical Chemical Sciences", "Prevention, Diagnosis and Treatment of Human Diseases" ]
W2070461977
Leydigia (Neoleydigia) cf. striata Birabén, 1939 (Crustacea: Cladocera: Chydoridae) from Colombia and its differentiation from L. (N.) cf. ipojucae (Brehm, 1938)
This paper concerns the chydorid cladoceran Leydigia (Neoleydigia) cf. striata Birabén, 1939 in plankton samples from Ciénaga El Convento, Colombia. The specimen from Colombia bears the diagnostic features of L (N) cf. striata as redescribed by Kotov and Elías-Gutiérrez (2003), Kotov et al. (2004), and Kotov, (2009). H...
[ "Environmental Biology, Ecology and Evolution", "Earth System Science" ]
10.3389/fpls.2018.00253
European forest cover during the past 12,000 years: A palynological reconstruction based on modern analogs and remote sensing
Characterization of land cover change in the past is fundamental to understand the evolution and present state of the Earth system, the amount of carbon and nutrient stocks in terrestrial ecosystems, and the role played by land-atmosphere interactions in influencing climate. The estimation of land cover changes using p...
[ "Earth System Science", "Environmental Biology, Ecology and Evolution" ]
10.18632/oncotarget.3826
Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment
The nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is a lipid ligand-inducible transcription factor associated with macrophage polarization. However, its function in tumor-associated macrophages (TAMs) has not been investigated to date. Here, we report the PPARβ/δ-regulated transcriptome and ...
[ "Immunity, Infection and Immunotherapy", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Physiology in Health, Disease and Ageing" ]
10.1111/geb.12326
Estimating species diversity and distribution in the era of Big Data: To what extent can we trust public databases?
Aim: Massive digitalization of natural history collections is now leading to a steep accumulation of publicly available species distribution data. However, taxonomic errors and geographical uncertainty of species occurrence records are now acknowledged by the scientific community - putting into question to what extent ...
[ "Environmental Biology, Ecology and Evolution", "Computer Science and Informatics" ]
10.1080/17588928.2014.907256
Predictive Processing Perceptual Presence And Sensorimotor Theory
AbstractMastery of sensorimotor contingencies can be viewed as attunement to potentialities. In our view, these potentialities have wider application than recognized in Seth’s account of sensory presence, and should pertain to all of sensory experience. Instead of appealing only to a notion of counterfactual richness, ...
[ "Neuroscience and Disorders of the Nervous System", "The Human Mind and Its Complexity" ]
10.1038/s41375-020-0929-3
Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia
To establish novel and effective treatment combinations for chronic myelomonocytic leukemia (CMML) preclinically, we hypothesized that supplementation of CMML cells with the human oncogene Meningioma 1 (MN1) promotes expansion and serial transplantability in mice, while maintaining the functional dependencies of these ...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1364/OL.40.000843
Balancing Of Thermal Lenses In Enhancement Cavities With Transmissive Elements
Thermal lensing poses a serious challenge for the power scaling of enhancement cavities, in particular when these contain transmissive elements. We demonstrate the compensation of the lensing induced by thermal deformations of the cavity mirrors with the thermal lensing in a thin Brewster plate. Using forced convection...
[ "Physical and Analytical Chemical Sciences", "Systems and Communication Engineering" ]
W4224218205
Weight regain and cardiometabolic effects after withdrawal of semaglutide: The <scp>STEP</scp> 1 trial extension
To explore changes in body weight and cardiometabolic risk factors after treatment withdrawal in the STEP 1 trial extension.STEP 1 (NCT03548935) randomized 1961 adults with a body mass index ≥ 30 kg/m2 (or ≥ 27 kg/m2 with ≥ 1 weight-related co-morbidity) without diabetes to 68 weeks of once-weekly subcutaneous semaglut...
[ "Physiology in Health, Disease and Ageing", "Prevention, Diagnosis and Treatment of Human Diseases" ]
W4224234887
Medición funcional en el dominio de la ética empírica
El presente artículo propone un enfoque empírico de la ética derivado de la teoría psicológica del juicio humano propuesta por Norman Anderson. Muestra cómo la metodología de esta teoría —denominada medición funcional— puede utilizarse para caracterizar las diversas posiciones personales que existen en todas las socied...
[ "The Human Mind and Its Complexity", "The Social World and Its Interactions" ]
980436
A single-molecule technology for resolving chaperone action in neurodegenerative diseases
A range of debilitating neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases, arise from the formation of amyloidogenic protein aggregates. Molecular chaperones can counteract aggregate formation, but their molecular action mechanisms remain poorly understood. This is chiefly due to the fundament...
[ "Neuroscience and Disorders of the Nervous System", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Prevention, Diagnosis and Treatment of Human Diseases", "Physical and Analytical Chemical Sciences" ]
10.1016/j.immuni.2012.01.016
Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire <sup>+</sup> Medullary Epithelium
The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) during the embryonic-neonatal period being both necessary and sufficient to establish long-lasting tolerance. Here we sh...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Immunity, Infection and Immunotherapy" ]
246799
Towards 4D Imaging of Fundamental Processes on the Atomic and Sub-Atomic Scale
State-of-the-art microscopy and diffraction imaging provides insight into the atomic and sub-atomic structure of matter. They permit determination of the positions of atoms in a crystal lattice or in a molecule as well as the distribution of electrons inside atoms. State-of-the-art time-resolved spectroscopy with femto...
[ "Fundamental Constituents of Matter", "Physical and Analytical Chemical Sciences" ]
10.4049/jimmunol.1001613
Pandemic H1N1 influenza a viruses are resistant to the antiviral activities of innate immune proteins of the collectin and pentraxin superfamilies
Acquired immune responses elicited to recent strains of seasonal H1N1 influenza viruses provide limited protection against emerging A(H1N1) pandemic viruses. Accordingly, pre-existing or rapidly induced innate immune defenses are of critical importance in limiting early infection. Respiratory secretions contain protein...
[ "Immunity, Infection and Immunotherapy", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1039/C6SC05338F
Selective Uni And Bidirectional Homologation Of Diborylmethane
Diborylmethane can be homologated uni- and bidirectionally by using enantiomerically pure lithium-stabilized carbenoids to give 1,2- and 1,3-bis(boronic esters), respectively, in good yield and with excellent levels of enantio- and diastereoselectivity. The high sensitivity of the transformation to steric hindrance ena...
[ "Synthetic Chemistry and Materials", "Physical and Analytical Chemical Sciences" ]
10.1039/c5ib00070j
The mechanotransduction machinery at work at adherens junctions
The shaping of a multicellular body, and the maintenance and repair of adult tissues require fine-tuning of cell adhesion responses and the transmission of mechanical load between the cell, its neighbors and the underlying extracellular matrix. A growing field of research is focused on how single cells sense mechanical...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1088/0004-637X/786/1/7
Does Segue Sdss Indicate A Dual Galactic Halo
We re-examine recent claims of observational evidence for a dual Galactic halo in SEGUE/SDSS data, and trace them back to improper error treatment and neglect of selection effects. In particular, the detection of a vertical abundance gradient in the halo can be explained as a metallicity bias in distance. A similar bia...
[ "Universe Sciences" ]
10.1057/jird.2013.1
Democracy, social welfare and political violence: The case of latin america
The return of democracy in Latin America has been associated with a decline in political violence, but also with a failure to redress welfare troubles or restore social justice. This essay provides an exploration of these problematic relationships. It argues that the impact of democracy on social welfare and internal c...
[ "The Social World and Its Interactions", "Institutions, Governance and Legal Systems" ]
10.1039/c4ta02022g
Cationic microporous polymer networks by polymerisation of weakly coordinating cations with CO2-storage ability
Microporous organic polymer networks with weakly coordinating cations in their backbone have been synthesised by metal catalysed C–C bond forming reactions.
[ "Synthetic Chemistry and Materials", "Materials Engineering" ]
10.1039/c6cp06907j
Accidental degeneracy in the spiropyran radical cation: charge transfer between two orthogonal rings inducing ultra-efficient reactivity
We unravel an original photoswitching mechanism in spiropyran radical cation.
[ "Physical and Analytical Chemical Sciences", "Synthetic Chemistry and Materials" ]
10.1093/qje/qjw010
Rethinking the effects of financial globalization
During the past three decades, many countries have lifted restrictions on cross-border financial transactions. We present a simple model that can account for the observed effects of financial globalization. The model emphasizes the role of imperfect enforcement of domestic debts and the interactions between domestic an...
[ "Individuals, Markets and Organisations", "Institutions, Governance and Legal Systems" ]
207667
Computational Anatomy of Fetal Brain
Studies about brain maturation aim at providing a better understanding of brain development and links between brain changes and cognitive development. Such studies are of great interest for diagnosis help and clinical course of development and treatment of illnesses. Several teams have begun to make 3D maps of developi...
[ "Neuroscience and Disorders of the Nervous System", "Computer Science and Informatics", "Mathematics", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1145/3158145
Proving Expected Sensitivity Of Probabilistic Programs
Program sensitivity, also known as Lipschitz continuity, describes how small changes in a program’s input lead to bounded changes in the output. We propose an average notion of program sensitivity for probabilistic programs—expected sensitivity—that averages a distance function over a probabilistic coupling of two outp...
[ "Computer Science and Informatics", "Mathematics" ]
10.1364/AO.55.005025
Subwavelength Micropolarizer In A Gold Film For Visible Light
We have designed and fabricated a 100 μm×100 μm four-sector binary subwavelength reflecting polarization microconverter in a gold film. Using finite-difference time-domain-aided numerical simulations and experiments, the micropolarizer was shown to convert an incident linearly polarized Gaussian beam of wavelength 532 ...
[ "Physical and Analytical Chemical Sciences", "Condensed Matter Physics" ]
10.1007/s13280-011-0218-5
Ecological implications of changes in the arctic cryosphere
Snow, water, ice, and permafrost are showing evidence of substantial change in the Arctic, with large variations among different geographical areas. As a result of these changes, some habitats and their associated ecosystems are expanding, while others are undergoing rapid contraction. The warming of the Arctic cryosph...
[ "Environmental Biology, Ecology and Evolution", "Earth System Science" ]
339231
Habitability of Martian Environments: Exploring the Physiological and Environmental Limits of Life
The low average temperature and low water activity of the Martian near-surface environment makes it challenging for living organisms to persist and propagate. Nonetheless, recent mission results indicate that environmental conditions exceed locally and temporarily the lower thresholds for life to exist. Furthermore, s...
[ "Universe Sciences", "Earth System Science", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1016/j.celrep.2016.11.011
Immunometabolic Pathways in BCG-Induced Trained Immunity
The protective effects of the tuberculosis vaccine Bacillus Calmette-Guerin (BCG) on unrelated infections are thought to be mediated by long-term metabolic changes and chromatin remodeling through histone modifications in innate immune cells such as monocytes, a process termed trained immunity. Here, we show that BCG i...
[ "Immunity, Infection and Immunotherapy", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.3390/su10082881
Metal mining's environmental pressures: A review and updated estimates on CO<inf>2</inf> emissions, water use, and land requirements
The significant increase in metal mining and the inevitability of the continuation of this trend suggests that environmental pressures, as well as related impacts, have become an issue of global relevance. Yet the scale of the impact remains, to a large extent, unknown. This paper examines the mining sector's demands o...
[ "Earth System Science", "Products and Processes Engineering" ]
Q3070024
Année de marque par Raivo Holm Programme de développement
Porter les affaires d’AS au niveau des activités méobury fortes. L’objectif est d’atteindre la reconnaissance et la croissance des marques de l’Année en Suède, en Finlande et dans les pays baltes. L’entrée sur de nouveaux marchés d’exportation potentiels.
[ "Individuals, Markets and Organisations" ]
10.1101/2020.02.19.955948
Full Cell Infiltration And Thick Tissue Formation In Vivo In Tailored Electrospun Scaffolds
Abstract Electrospun (ESP) scaffolds are a promising type of tissue engineering constructs for large defects with limited depth. To form new functional tissue, the scaffolds need to be infiltrated with cells, which will deposit extracellular matrix. However, due to dense fiber packing and small pores, cell and tissue i...
[ "Materials Engineering", "Cell Biology, Development, Stem Cells and Regeneration", "Products and Processes Engineering" ]
10.1016/j.isci.2019.11.027
Altered Visual Plasticity in Morbidly Obese Subjects
Growing evidence indicates a close link between energy metabolism and neural plasticity as obesity is associated with alterations of cognitive functions, memory, and hippocampal neurogenesis. However, it is still unknown whether obesity can affect low-level sensory plasticity. Here we investigated this issue by probing...
[ "Neuroscience and Disorders of the Nervous System", "Physiology in Health, Disease and Ageing" ]
10.1261/rna.052548.115
The use of duplex-specific nuclease in ribosome profiling and a user-friendly software package for Ribo-seq data analysis
Ribosome profiling is a technique that permits genome-wide, quantitative analysis of translation and has found broad application in recent years. Here we describe a modified profiling protocol and software package designed to benefit more broadly the translation community in terms of simplicity and utility. The protoco...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems", "Computer Science and Informatics" ]
Q11071
Innovation of the preparation of the moulding mixture and the properties of castings
This project concerns an application of completed development, where we have successfully cooperated with the Technical University of Liberec (TUL) and whose main aim is to increase the quality-technical properties of the moulding mixture itself through the introduction of the preparation of the moulding mixture (moder...
[ "Products and Processes Engineering", "Materials Engineering" ]
10.1103/PhysRevLett.119.144502
Passive Control of Viscous Flow via Elastic Snap-Through
We demonstrate the passive control of viscous flow in a channel by using an elastic arch embedded in the flow. Depending on the fluid flux, the arch may "snap" between two states - constricting and unconstricting - that differ in hydraulic conductivity by up to an order of magnitude. We use a combination of experiments...
[ "Condensed Matter Physics", "Products and Processes Engineering" ]
10.1145/3027063.3027073
Hcitools Strategies And Best Practices For Designing Evaluating And Sharing Technical Hci Toolkits
Over the years, toolkits have been designed to facilitate the rapid prototyping of novel designs for graphical user interfaces, physical computing, fabrication, tangible interfaces and ubiquitous computing. However, although evaluation methods for HCI are widely available, particular techniques and approaches to evalua...
[ "Computer Science and Informatics" ]
10.1111/nph.16446
Auxin canalization and vascular tissue formation by TIR1/AFB-mediated auxin signaling in Arabidopsis
Plant survival depends on vascular tissues, which originate in a self-organizing manner as strands of cells co-directionally transporting the plant hormone auxin. The latter phenomenon (also known as auxin canalization) is classically hypothesized to be regulated by auxin itself via the effect of this hormone on the po...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Cell Biology, Development, Stem Cells and Regeneration", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1109/ITA.2013.6502937
Random access with physical-layer network coding
Leveraging recent progress in compute-and-forward we propose an approach to random access that is based on physical-layer network coding: When packets collide, it is possible to recover a linear combination of the packets at the receiver. Over many rounds of transmission, the receiver can thus obtain many linear combin...
[ "Systems and Communication Engineering", "Computer Science and Informatics" ]
10.1007/978-3-319-56614-6_19
Toward Fine Grained Blackbox Separations Between Semantic And Circular Security Notions
We address the problems of whether t-circular-secure encryption can be based on \((t-1)\)-circular-secure encryption or on semantic (CPA) security, if \(t = 1\). While for \(t = 1\) a folklore construction, based on CPA-secure encryption, can be used to build a 1-circular-secure encryption with the same secret-key and ...
[ "Computer Science and Informatics" ]
10.1126/science.1233028
Cellular self-defense: How cell-autonomous immunity protects against pathogens
Our prevailing view of vertebrate host defense is strongly shaped by the notion of a specialized set of immune cells as sole guardians of antimicrobial resistance. Yet this view greatly underestimates a capacity for most cell lineages - the majority of which fall outside the traditional province of the immune system - ...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Immunity, Infection and Immunotherapy" ]
W2014352723
The Role of Thiopurines in Reducing the Need for Surgical Resection in Crohn's Disease: A Systematic Review and Meta-Analysis
The thiopurine (TP) analogs azathioprine and mercaptopurine have proven efficacy in inducing and maintaining clinical remission in Crohn's disease (CD). Their impact on the long-term need for surgery is uncertain since studies have reported conflicting results. The aim of this systematic review was to summarize and eva...
[ "Prevention, Diagnosis and Treatment of Human Diseases", "Immunity, Infection and Immunotherapy" ]
208561
Probing the relevance of carbene binding motifs in enzyme reactivity
Histidine (His) is an ubiquitous ligand in the active site of metalloenzymes that is assumed by default to bind the metal center through one of its nitrogen atoms. However, protonation of His, which is likely to occur in locally slightly acidic environment, gives imidazolium sites that can bind a metal in a carbene-typ...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Physical and Analytical Chemical Sciences", "Synthetic Chemistry and Materials" ]
10.1051/0004-6361/201833775
Weak Lensing Shear Measurement With Machine Learning Teaching Artificial Neural Networks About Feature Noise
Cosmic shear is a primary cosmological probe for several present and upcoming surveys investigating dark matter and dark energy, such as Euclid or WFIRST. The probe requires an extremely accurate measurement of the shapes of millions of galaxies based on imaging data. Crucially, the shear measurement must address and c...
[ "Universe Sciences", "Computer Science and Informatics" ]
10.1038/nchem.1860
State-resolved diffraction oscillations imaged for inelastic collisions of NO radicals with He, Ne and Ar
Just as light scattering from an object results in diffraction patterns, the quantum mechanical nature of molecules can lead to the diffraction of matter waves during molecular collisions. This behaviour manifests itself as rapid oscillatory structures in measured differential cross-sections, and such observable featur...
[ "Physical and Analytical Chemical Sciences", "Fundamental Constituents of Matter" ]
10.3390/polym10080913
Preparation and identification of optimal synthesis conditions for a novel alkaline anion-exchange membrane
The physicochemical and mechanical properties of new alkaline anion-exchange membranes (AAEMs) based on chitosan (CS) and poly(vinyl alcohol) (PVA) polymers doped with unsupported copper nanoparticles (NPs) and copper exchanged over different porous materials were investigated regarding ion-exchange capacity (IEC), OH-...
[ "Physical and Analytical Chemical Sciences", "Materials Engineering" ]
10.1111/mmi.13981
Toxoplasma gondii TFP1 is an essential transporter family protein critical for microneme maturation and exocytosis
Invasion and egress are two key steps in the lytic cycle of Apicomplexa that are governed by the sequential discharge of proteins from two apical secretory organelles called micronemes and rhoptries. In Toxoplasma gondii, the biogenesis of these specialized organelles depends on the post Golgi trafficking machinery, fo...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
Q2032636
INNOVATION
TRATTASI DI UN PROGETTO DELLA FILIERA SISTEMA CASA . IL PROGETTO Ê IL COMPLETAMENTO DELL'ATTIVITà DI RISTRUTTURAZIONE DELL'AZIENDA AVVIATA NEL 2016 DAL SOCIO LEGNOTECNICA A SEGUITO DELL'ACQUISIZIONE DEL 100% DELLE QUOTE. SE NON CI FOSSE STATA L'ACQUISIZIONE , LA SOCIETà SAREBBE STATA CHIUSA CON CONSEGUENZE PESANTI I...
[ "Individuals, Markets and Organisations", "Products and Processes Engineering" ]
US 2013/0040802 W
SYSTEM AND METHOD FOR DYNAMIC TRANSACTION MANAGEMENT AND COLLABORATIVE AUTHORING OF A NEGOTIABLE DOCUMENT
A system and method for enabling coordinated, collaborative, data-driven document negotiation among multiple, divergent parties, either internally or externally, in a virtual environment. A comprehensive, singular, transaction management platform that transforms documents from a manual, text-based and paper-laden busin...
[ "Computer Science and Informatics", "Systems and Communication Engineering" ]
10.1021/acsaem.8b01663
Perylene Polyimide-Polyether Anodes for Aqueous All-Organic Polymer Batteries
Aqueous batteries are a safe, sustainable, and a low cost alternative to store energy. Thus, there is an ongoing search for new battery electrode materials with redox potentials in the voltage range corresponding to the electrochemical stability window of water. Particularly, organic materials are attracting considerab...
[ "Synthetic Chemistry and Materials", "Materials Engineering", "Physical and Analytical Chemical Sciences" ]
10.1242/jcs.173013
The lysine demethylase LSD1 is required for nuclear envelope formation at the end of mitosis
The metazoan nucleus breaks down and reassembles during each cell division. Upon mitotic exit, the successful reestablishment of an interphase nucleus requires the coordinated reorganization of chromatin and formation of a functional nuclear envelope. Here we report that the histone demethylase LSD1 plays a crucial rol...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
US 86985797 A
Seismic shock absorbing pier
A seismic shock absorbing pier including a cylindrical column having an upper end and a lower end; a slide stop having a load bearing surface, the slide stop being fixedly attached to the cylindrical column so that its load bearing surface is upwardly oriented; a shock absorbing spring having an upper end and a lower e...
[ "Products and Processes Engineering", "Materials Engineering" ]
W111620743
Classification of Patients with Alzheimer’s Disease Based on Structural MRI Using Locally Linear Embedding (LLE)
Several methods have been used to classify patients with Alzheimer’s disease (AD) or its prodromal stage, mild cognitive impairment (MCI) from cognitive normal (CN) based on T1-weighted MRI. In this study, we used LLE to discriminate 453 subjects form the ADNI database. We conducted six pair wise classification experim...
[ "Neuroscience and Disorders of the Nervous System", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.22364/mhd.45.2.11
Numerical simulation of unsteady mhd flows and applications
We present a robust numerical method for solving the compressible Ideal Magneto-Hydrodynamic equations. It is based on the Residual Distribution (RD) algorithms already successfully tested in many problems [1]. We adapted the scheme to the multi-dimensional unsteady MHD model. The constraint ∇ B=0 is enforced by the us...
[ "Mathematics", "Fundamental Constituents of Matter", "Computer Science and Informatics" ]
10.1103/PhysRevB.85.115129
Role of nonlocal exchange in the electronic structure of correlated oxides
We present a systematic study of the electronic structure of several prototypical correlated transition-metal oxides: VO 2, V 2O 3, Ti 2O 3, LaTiO 3, and YTiO 3. In all these materials, in the low-temperature insulating phases the local and semilocal density approximations (LDA and GGA, respectively) of density-functio...
[ "Condensed Matter Physics", "Physical and Analytical Chemical Sciences" ]
10.1126/scisignal.aaf9126
Science signaling podcast for 3 May 2016: Innate lymphoid cell plasticity
This Podcast features an interview with Rachel Golub and Eric Vivier, authors of two Research Articles that appear in the 3 May 2016 issue of Science Signaling, about plasticity of innate lymphoid cells (ILCs). ILCs are related to the T cells and B cells of the adaptive immune system, and they regulate immune responses...
[ "Immunity, Infection and Immunotherapy", "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1007/s12551-017-0289-z
Monomer-dependent secondary nucleation in amyloid formation
Secondary nucleation of monomers on the surface of an already existing aggregate that is formed from the same kind of monomers may lead to autocatalytic amplification of a self-assembly process. Such monomer-dependent secondary nucleation occurs during the crystallization of small molecules or proteins and self-assembl...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Physical and Analytical Chemical Sciences" ]
220950
Responsive results-based management and capacity building for eu sustainable fisheries partnership agreement- and international waters
The objective of FarFish is to improve knowledge on and management of EU fisheries outside Europe, while contributing to sustainability and long term profitability. 21% of EU catches originate from non-EU waters. These fisheries are often poorly regulated, management decisions are sometimes based on limited knowledge a...
[ "Environmental Biology, Ecology and Evolution", "Individuals, Markets and Organisations", "Earth System Science" ]
10.1002/qj.2039
Wind-gust parametrizations at heights relevant for wind energy: A study based on mast observations
Wind gusts are traditionally observed and reported at the reference height of 10 m and most gust parametrization methods have been developed only for this height. In many practical applications, e. g. in wind energy, the relevant heights are, however, up to a few hundred metres. In this study, mean gustiness condition...
[ "Products and Processes Engineering", "Earth System Science" ]
10.1088/0951-7715/25/12/3487
Expanding Semiflows On Branched Surfaces And One Parameter Semigroups Of Operators
We consider expanding semiflows on branched surfaces. The family of transfer operators associated with the semiflow is a one-parameter semigroup of operators. The transfer operators may also be viewed as an operator-valued function of time and so, in the appropriate norm, we may consider the vector-valued Laplace trans...
[ "Mathematics" ]
10.1063/1.5094864
Analysis And Simulation Of The Multiple Resistive Switching Modes Occurring In Hfox Based Resistive Random Access Memories Using Memdiodes
In this work, analysis and simulation of all experimentally observed switching modes in hafnium oxide based resistive random access memories are carried out using a simplified electrical conduction model. To achieve switching mode variation, two metal-insulator-metal cells with identical stack combination, but varying ...
[ "Condensed Matter Physics", "Materials Engineering", "Physical and Analytical Chemical Sciences", "Systems and Communication Engineering" ]
10.1007/978-3-030-33676-9_38
Iterative Greedy Matching For 3D Human Pose Tracking From Multiple Views
In this work we propose an approach for estimating 3D human poses of multiple people from a set of calibrated cameras. Estimating 3D human poses from multiple views has several compelling properties: human poses are estimated within a global coordinate space and multiple cameras provide an extended field of view which ...
[ "Computer Science and Informatics" ]
681587
Engineering of hybrid cells using lab-on-chip technology
The overall aim of the here described projects is to learn fundamental characteristics of cellular organization and compartmentalization, in particular the role of the lipid membrane, and to exploit this knowledge for engineering minimal cells with a great impact in the context of synthetic biology and also for pharmac...
[ "Materials Engineering", "Biotechnology and Biosystems Engineering", "Physical and Analytical Chemical Sciences", "Prevention, Diagnosis and Treatment of Human Diseases" ]