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gen_0893b52fc6f046ef2d66ed06af0ef6f1 | Dissemination Core | NIH | RICE UNIVERSITY | 1U54EB034652-01 | ABSTRACT The traditional staged pipeline for moving innovations from prototype to efficacy and effectiveness testing to real‐world implementation generally results in slow dissemination and uptake of effective interventions and technologies. The CITEC Dissemination Core (DC) will work to accelerate efficient and effective translation and adoption of POC technologies for cancer screening and early detection by engaging in activities that are crucial to achieve optimal adoption and implementation. The DC will work to: 1) ensure that clinical and user needs inform device development and design; 2) proactively assess and address barriers to integrating POC technologies into real‐world health care delivery processes; and 3) train technology developers and end users to develop, evaluate, implement, and commercialize POC technologies for equitable cancer screening and diagnosis. The first aim of the DC is to collaborate with the Technical and Clinical Cores to assess, refine, formally document, and broadly communicate high‐priority unmet clinical needs associated with cancer screening and early detection that are targets for POC technologies to improve equitable cancer screening and early detection. The DC will carry out on‐site needs assessment visits at multiple global sites including medically underserved settings in the US, Brazil and Mozambique. The DC will document and publish consensus POC Technology Needs Statements each year and these will be disseminated broadly in partnership with professional societies. The second aim of the DC is to develop an implementation science roadmap for introducing POC technologies in low‐resource settings based on a case study around implementation of an existing but under‐utilized technology for cervical cancer screening. The third aim of the DC is to provide a portfolio of interdisciplinary training and educational opportunities targeted to technology developers and end‐users to accelerate the development, evaluation, implementation, and commercialization of POC technologies for equitable cancer screening and early detection. We will partner with professional societies to offer engaging, hands‐on pre‐conference workshops. Knowledge generated through these activities will inform and refine the work of other CITEC cores and POCTRN centers and will help ensure that technology prototypes supported by CITEC will have a high rate of success for market adoption, scale‐up, and implementation to address global cancer health disparities. According to Instructions for the Submission of Mulit-Component Applications in PAR-22-203, for Administrative, Technology, Clinical and Dissemination Cores: “Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required. However, eRA systems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components.” | Research Centers | 6project_grants_public |
gen_df1022b93ba180deed0d14cb1ce83c0f | Structural and functional characterization of synaptic adhesion GPCR ADGRB3 binding interactions | NIH | UNIVERSITY OF UTAH | 1R03TR004497-01 | ABSTRACT Adhesion GPCRs (aGPCRs) represent a major class of GPCRs and are characterized by the presence of extracellular adhesive regions and membrane proximal GAIN domains that are linked to typical GPCR 7TM and cytoplasmic regions. aGPCRs have important roles including cell adhesion and migration, synaptogenesis and immunity. Recent structural studies have yielded considerable insights into their activation at the level of the 7TM and cytoplasmic regions, showing that insertion of a stachel peptide present in the stalk region into the transmembrane domains drives conformational changes during activation. In contrast, adhesive interactions of the membrane distal adhesive regions remain poorly characterized and, in particular, the structural mechanisms by which these interactions cause release of the stachel sequence for activation are unknown. This proposal aims to structurally characterize the adhesive interactions and activation mechanism of ADGRB3, a member of an aGPCR family that is found at neuronal synapses and in heart muscle that is critical for synaptogenesis, synaptic plasticity, synapse elimination and myoblast fusion. We will employ structure-based approaches including cryo-EM structure determination of ADGRB3 and its adhesive complexes complemented by functional assays to relate structural insights to receptor activation. Aim 1 focuses on the structure of the complete ADGRB3 ectodomain and its adhesive fragments using a combination of structural approaches including cryo-EM, x-ray crystallography, and SAXS. Successful outcome of this aim would provide insights into the organization of the ADGRB3 adhesive region and its coupling to the membrane proximal activation regions. Aim 2 focuses on characterization of ADGRB3 adhesive binding interactions with previously identified and candidate ligands using biophysical and in vitro binding assays to delineate binding regions and complex compositions and stoichiometries. Structures of defined adhesive complexes will be determined using cryo-EM and x-ray crystallography and complexes formed between lipid membranes will be visualized by cryo-ET to examine their organization and assembly in a near-native state. Activation of ADGRB3 by adhesive ligand binding will be assessed in functional assays and effects of mutations targeting identified interfaces and key structural residues will be tested. Successful completion of this aim will provide direct insights into ADGRB3 adhesion and activation of aGPCR signaling. Overall, the proposal aims to provide fundamental mechanistic insights that could identify new targets for therapeutics. NARRATIVE Adhesion G-protein coupled receptors (aGPCRs) are involved in critical biological processes including cell adhesion and migration, synaptogenesis and immunity, and represent desirable drug targets. Recent advances have revealed details of their signaling mechanism but their adhesive binding interactions and how those interactions switch on signaling remain poorly understood. We aim to shed light on the adhesive properties of the ADGRB1-3 family of aGPCRs through structural approaches and binding interaction studies to identify new therapeutic targets. | Non-SBIR/STTR | 6project_grants_public |
gen_afb55e9f04ece54368bf75e71ac4dc3f | Small RNA-mediated warfare between viruses and their hosts | NIH | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | 1R35GM150649-01 | PROJECT SUMMARY Non-coding RNAs (ncRNAs) constitute the majority of RNAs present within the human cell, and are potent regulators of cellular processes, including translation, splicing, and post-transcriptional messenger RNA (mRNA) control. Like humans, viruses produce ncRNAs, whose functions are still largely unknown. Given that viruses evolved to maximize the information contained within their small genomes, all viral ncRNAs are postulated to be functional. Our lab studies the mechanisms by which small viral ncRNAs modulate host and viral processes, the knowledge of which will contribute to the development of new approaches to treat human disease. In the next five years, we will elucidate the roles of two distinct viral ncRNAs classes: small nuclear RNAs (snRNAs) expressed by an oncogenic g-herpesvirus (Project 1), and a microRNA (miRNA) produced by SARS-CoV-2, a virus that causes acute respiratory disease (Project 2). g-herpesviruses are DNA viruses, which during latency induce host cell transformation and oncogenesis. The latent viral genes produce several proteins and multiple ncRNAs. During its latency, herpesvirus saimiri, a classic g-herpesvirus, expresses seven snRNAs, known as HSURs. Unlike human snRNAs, HSURs were not linked to mRNA splicing, but instead to regulating host RNA levels in the cytoplasm. Interestingly, our results indicate that HSURs predominantly localize to the nucleus, where their roles remain unknown. Additionally, we observe that HSURs selectively translocate host cytoplasmic RNA-binding proteins into the nucleus. In Project 1, we will investigate the nuclear roles of viral snRNAs to explore unknown functions for host RNA-binding proteins and to gain insights into g-herpesviral transformation. SARS-CoV-2, a large RNA virus, is the causative agent of the coronavirus disease 2019 and the source of the current pandemic. We and others have recently discovered a miRNA expressed by SARS-CoV-2, named CoV-miR-O7a, which downregulates host genes involved inter alia in interferon signaling. Our preliminary data show that CoV-miR-O7a is abundantly present inside SARS-CoV-2 virions. We hypothesize that CoV-miR-O7a (and perhaps other ncRNAs) are selectively incorporated into virions to allow for early manipulation of host gene expression. In Project 2, we will investigate the mechanism and significance of viral miRNA incorporation into nascent virions to understand as yet unknown aspects of SARS-CoV-2 pathogenesis and to describe the previously unexplored way in which viruses inhibit host antiviral responses. Our multidisciplinary approaches, combined with the flexibility of MIRA funding, will lead to the establishment of a unique research program centered around understanding of small RNA biology in the context of viral infection. In elucidating functions of small viral ncRNAs, this study will advance the fields of RNA biology and virology. Such knowledge can lead to identification of novel targets for treatment of viral disease, including virally-induced cancers. PROJECT NARRATIVE The vast majority of transcripts within the cell consist of non-coding RNAs, which can modulate almost every molecular process. Viruses, unsurprisingly, also produce their own non-coding RNAs that can hijack host machineries to regulate both viral and host pathways. We will study the still highly elusive viral non-coding RNA biology, understanding of which will ultimately lead to new treatment options for human diseases. | Non-SBIR/STTR | 6project_grants_public |
gen_f554277b14e21642ab1d3da2021df02d | Creating diverse communities in support of diabetes and metabolism research | NIH | UNIVERSITY OF MICHIGAN AT ANN ARBOR | 5K26DK138307-02 | Project Summary/Abstract Career development in addition to mentorship, sponsorship and allyship are key aspects needed for trainees as they navigate through training and in their future careers. This K26 application seeks to directly support Dr. Singer’s effort to engage in direct research mentorship as well as developing and supporting a mentorship and learning community for trainees engaged in diabetes, obesity and metabolism research. Dr. Singer’s research in equity and career development along with engaged roles in diversity, equity and inclusion and graduate and faculty development uniquely poise her engage in the aims of this proposal. Aim 1 – Mentoring scientists to perform mechanistic research investigating sex differences in meta-inflammation and understand mechanisms of myeloid inflammation in adolescent metabolic disease. Dr. Singer will focus on recruiting and mentoring at least two graduate students or postdoctoral researchers within her laboratory, with additional support for equitable recruiting and focus on trainee career development. Aim 2 – Supporting graduate students and postdoctoral fellows in a learning community within the pipeline of NIDDK supported research efforts. The University of Michigan Diabetes Research Center and Michigan Nutrition Obesity Research Center provide opportunities for trainee engagement and encompass a large, diverse group of trainees. With this community we are poised to create a learning community with peer mentorship. This award will support Dr. Singer’s continued development as a mentor and leader, supporting trainees from diverse backgrounds including under-represented groups. Creating this supportive training embedded in a targeted research area has the potential for long-lasting and sustained career development of cohorts impacting diabetes and obesity. Hence this support will go beyond the mentoring of individuals to developing future opportunities and leaders in the field. Project Narrative The goal of this application is to support Dr. Singer's efforts and career development as a mentor to early career researchers through both individualized training and a cohort focused training program. She will develop the diabetes and obesity focused investigator pipeline with directed mentoring in her laboratory-based research focusing on sex differences in meta-inflammation and studies of meta-inflammatory monocytes in adolescent insulin resistance. The impact of this mentoring plan is broadened by bringing focused training on diversity, equity and inclusion, leadership and career development, and peer mentorship to cohorts of graduate and post-doctoral trainees in diabetes, obesity and metabolism research to build networks that support future leaders in the field. | Other Research-Related | 6project_grants_public |
gen_193c81725252dfdcc564f560eb4e9a42 | Developing Therapeutic Gel Embolic Agents for Arteriovenous Malformation Embolization | NIH | NORTH CAROLINA STATE UNIVERSITY RALEIGH | 5R03EB033633-02 | PROJECT SUMMARY Arteriovenous malformation (AVM) is an abnormal connection between an artery and vein that bypasses the normal capillary circulation, resulting in a tangle of vessels called a nidus. The malformation results in excessive stress on the venous wall, and can cause the rupturing of overstressed veins. Brain AVMs are particularly concerning since brain hemorrhage has the most severe complications, including seizures and neurologic deficits. The mortality rate after brain AVM rupture ranges from 12%-66.7%, and 23%-40% of survivors have significant disability. Furthermore, localized inflammation is found to be responsible for brain AVM progression and rupture. Anti-inflammatory drug therapy may, therefore, be a possibility to stabilize brain AVMs. Current treatment for brain AVMs includes microsurgery, embolization and radiosurgery. In embolization, which is the focus of this work, liquid embolic agents are delivered through catheters to embolize upstream or within the AVM shunt, aiming to return venous pressure to normal. The main challenge in embolizing AVMs stems from the difficulty involved with adequately penetrating the dense, tortuous and low resistance nidus. Proximal occlusion leads to the development of collateral vessels, promoting angiogenesis. Therefore, blockage of both nidus and the feeding arteries is essential for successful embolization. Current FDA approved embolic systems for brain AVM embolization include Onyx and n-butyl cyanoacrylate. Both are liquid embolic agents that undergo liquid- solid transition once in contact of blood. They are intended to travel distally from the site of release to penetrate fine vasculature. Despite clinical availability, both liquids have significant drawbacks and cannot serve as curative treatment of AVM. Limitations include toxicity from organic solvents, difficulty in delivery, danger of being washed away, lack of universality to block wide range of vasculature sizes, no intrinsic radiopacity for visualization on X- ray, and lack of therapeutics. In this proposal, we will develop gel embolic agent as a minimally invasive platform that is biocompatible, imageable, durable, hemostatic and anti-inflammatory to embolize and stabilize AVMs. We posit that gel embolic agents containing natural crosslinker, genipin, will 1) offer flexibility to penetrate different AVM geometries/sizes, 2) enhance mechanical robustness of the clot-gel system in embolized AVMs to prevent migration, and 3) serve as an anti-inflammatory therapy for AVM stabilization. In Aim 1, we will develop different gel compositions for effective embolization. In Aim 2, we will evaluate the gel’s mechanical properties, injectability and in vitro occlusion ability to optimize occlusion capability. Lastly in Aim 3, we will study the biological properties of the gels in vitro using relevant cell lines for biosafety evaluation and therapeutic characterization. Successful completion of this study will show that therapeutic gel embolic agents can be used safely and occlude effectively with therapeutic characteristics. This pilot study will set the stage for further in vivo testing in large animal studies using clinically relevant AVM models. We envision that this embolization platform can be widely disseminated to other applications, such as venous hypertension, aneurysms, and tumor embolization. PROJECT NARRATIVE Rupturing of arteriovenous malformation (AVM) in the brain is a serious medical problem that can cause significant morbidity and mortality, and often requires urgent embolization to stop bleeding. Currently used FDA approved liquid embolic agents for brain AVMs are associated with significant limitations, including toxicity from organic solvents, difficulty in delivery, danger of being washed away, lack of universality to block wide range of vasculature sizes, no intrinsic radiopacity for visualization on X-ray, and lack of therapeutic treatment. To address the aforementioned issues, we propose to develop biocompatible injectable gel embolic agents that are visible on various imaging modalities, offer flexibility to penetrate varying AVM vasculature geometry and serve as therapeutic carrier for the minimally invasive treatment of brain AVMs. | Non-SBIR/STTR | 6project_grants_public |
gen_b5f0bb1f82e1844f271d3e0d47b78746 | Development of data driven and AI empowered systems biology to study human diseases | NIH | OREGON HEALTH & SCIENCE UNIVERSITY | 7R35GM150971-02 | Project Summary Systems biology models provide an effective way to study the functional impact of biological process within complex disease system. Despite a plethora of knowledge on the differential equation-based systems biology model have gained, there are still major gaps in raising dynamic models within the context of human diseases. Essentially, the parameters involved in the non-linear dependencies are largely unknown under disease conditions and the systems biology models are always within a reductionist paradigm, which can hardly characterize the complicated disease system. The large amount of single-cell, spatial or tissue multi-omics data obtained from disease tissue has been proven to be endowed with the potential to deliver information on a cell functioning state and its underlying phenotypic switches. Hence, advanced systems biology models and computational tools are in pressing need to empower reliable characterization of biological processes and their functional roles in disease by using multi-omics data. Our preliminary data include (1) a new computational method to approximate systems biology model using transcriptomics data, and (2) computational principles to approximate dynamic system by using omics data, which form the methodology and theoretical foundations of this project. In this MIRA project, I proposed to develop a suite of novel computational methods, systems biology models and quantitative metrics to bring the following unmet capabilities: (1) A computational framework to establish dynamic models using omics data, which will enable the following analyses to study a complex disease system: (i) assessing sample-wise activity of biological processes; (ii) perturbation analysis to evaluate the impacts of biological features or model structures to the system, which could serve as new drug targets, and (iii) evaluating how the system evolve through disease progression; (2) A natural language processing-based extraction of biological functions and relations to automatically establish context specific knowledge of system structure and components from scientific literature datal; and (3) computational principles and theories of the identifiability and mathematical representation of dynamic systems in omics data. By implementing these methods into multi-omics data analysis, we plan to address the following outstanding biological questions: (i) identification of molecular features with high impact to metabolic variations in different diseases, (ii) the role of metabolism in fueling epigenetic regulation, (iii) transcriptional regulation of metabolism and other biological processes, (iv) functional annotation of genetic variations, and (v) assessment of biochemical variations. We will also develop novel knowledge representation and transfer of metabolic and other variations in pan-disease analysis to aid in better understanding of the basic disease pathology and promote the precision medicine research, including prediction and validation of new biomarkers, nutrition recommendation, and drug repurposing. Successful execution of the proposed research will provide a suite of computational capabilities to quantify and study general biological processes that could be broadly utilized by the biomedical research community. Project Narrative The goal of this MIRA project is to develop data-driven and AI empowered systems biology approaches to accurate assess biological processes by using omics data, including a natural language processing-based model construction, a new AI framework to approximate systems biology models, and related computational principles. The proposed framework will systematically characterize the biological processes, such as metabolic and signaling pathways, as well as their heterogeneities and crosstalk in disease tissue microenvironment, and identify key influencing factors in complex disease by analyzing omics data. Given the pervasive role of metabolism and signaling pathways in essentially every aspect of the disease pathology, the proposed infrastructure with accurate characterization of functional variations could have far-reaching impact in our knowledge on the basis of disease biology, clinical early diagnosis and prevention, and disease management. | Non-SBIR/STTR | 6project_grants_public |
gen_b9827988d579d1cfaf552ef3095178eb | NOVEL HUMORAL AND CELLULAR BIOMARKERS OF AUTOIMMUNE DISEASES CAUSED BY IMMUNOTHERAPY | NIH | BAYLOR COLLEGE OF MEDICINE | 1R21AI159379-01A1 | Immunotherapy has transformed the treatment landscape for a wide range of human malignancies. Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block the immune regulatory “checkpoint” receptors, the Cytotoxic T-Lymphocyte Associated Protein 4 (CTLA-4), Programmed Cell Death 1 (PD-1), or its ligand PD- L1. ICIs produce durable responses in many patients. However, coupled with their success, these treatments commonly evoke a wide range of immune-related adverse events (irAEs), such as diabetic ketoacidosis (DKA) or thyroid disease, appearing to occur more frequently than originally expected. Immunotoxicity from cancer immunotherapy occurs in up to 90%, whereas autoimmune endocrine diseases occur in approximately 50% of patients treated with antibodies to CTLA-4 and/or PD-1/PD-L1. These irAEs can be serious or even life- threatening, such as autoimmune type 1 diabetes (T1D) presenting in DKA, and primary adrenal insufficiency caused by autoimmune adrenalitis. A recent study showed a marked increase of ICI-related autoimmune diabetes; reported in over 50% of the patients, with half of these patients presenting in DKA (50.2%). Thus, reliable biomarkers are needed to accurately stratify the risk of irAEs in patients who are candidates for these therapies (Aim I); these biomarkers may point to novel molecular pathways that could be targeted to prevent irAEs caused by immune checkpoint blockade (Aim II). Specifically, we will utilize the state-of-the-art single-cell platforms to investigate and characterize the comprehensive phenotypic and functional analyses of systemic cellular networks in patients with ICI-induced endocrinopathies. Our studies are greatly facilitated by the Baylor College of Medicine Immunotoxicity Working Group. Understanding the immunologic factors and the biomarkers associated with ICI-mediated inflammatory toxicities will be useful for the identification and early treatment of ICI-induced irAEs, and it may provide new insights into the pathoetiology and treatment of autoimmune endocrine diseases. PROJECT NARRATIVE Immune checkpoint inhibitors can result in long-lasting clinical responses in a variety of advanced or metastatic malignancies, but approximately half of patients receiving these drugs develop autoimmune endocrinopathies. Our proposal brings together expertise in three complementary areas such as endocrinology, autoimmunity, and oncology. The outcome of this investigation will provide mechanistic insights into immunotherapy-related adverse events and may provide the groundwork for understanding how to limit the toxicity of immunotherapy as well as improving treatments of autoimmune endocrine diseases. | Non-SBIR/STTR | 6project_grants_public |
gen_2083fa85976e8163640d3ba24fe005cd | Bile acid receptor signaling in retinopathy of prematurity | NIH | AUGUSTA UNIVERSITY | 1R01EY034568-01 | The proposed studies are relevant to the treatment of retinopathy of prematurity (ROP), the leading cause of preventable blindness in children. An important trigger for ROP development is the exposure of premature infants to oxygen after birth. This delays normal retinal vascular growth, still taking place in the premature retina. When the infant is brought back to room air, this leads to tissue ischemia, abnormal retinal neovascularization, and, possibly, retinal detachment and blindness. Available interventions are applied in the most advanced stages of the disease and consist of ablation of retinal neovascular tufts or intravitreal injections of anti-angiogenic factors (i.e., VEGF). All these procedures and treatments are associated with severe side effects, including significant loss of visual field and late recurrences. We have recently found that agonists of the nuclear receptor farnesoid-X-receptor (FXR) exert protective effects in an experimental model of ROP (oxygen-induced retinopathy; OIR). Interestingly, we have also found that FXR expression and levels of FXR endogenous ligands are downregulated in OIR, further supporting the hypothesis that leveraging/restoring FXR-dependent signaling could exert key protective effects in ROP/OIR. To confirm this, we found that FXR is present in retinal astrocytes and endothelial cells that are primarily affected in OIR. FXR stimulation may elicit anti-apoptotic responses in astrocytes and anti-angiogenic effects in retinal endothelial cells, thus targeting two key events involved in the induction and progression of OIR. Our working hypothesis is that alterations in retinal FXR signaling play a key role in ROP pathogenesis and the pharmacological modulation of these pathways represents a new therapeutic tool in limiting ROP pathology. We have designed experiments to be conducted in vivo, using the OIR model and in vitro experimental settings to 1) investigate the effects of modulating FXR receptor signaling in OIR; 2) investigate FXR signaling in retinal astrocytes and endothelial cells in OIR. The potential outcomes of the proposed studies could fill the need for new and better therapies for ROP. Retinopathy of prematurity (ROP) is the leading cause of blindness in children. There are limited therapeutic options for this severe ocular pathology. Our overall goal is to identify new and more effective therapies for ROP. In particular, we will explore and characterize the potential therapeutic effects of the nuclear receptor farnesoid- X-receptor (FXR) agonists in experimental models of ROP. | Non-SBIR/STTR | 6project_grants_public |
gen_4455aa172a75322ed63aa6118c9ffb68 | Examination of sex hormone alteration on post-operative pain development and treatment | NIH | TEXAS TECH UNIVERSITY HEALTH SCIS CENTER | 5R35GM150979-02 | PROJECT SUMMARY/ABSTRACT Chronic postoperative pain affects a small but significant surgery population. The goal of this project is to preclinically translate and determine the overall contribution of altered sex hormone levels in vulnerable patient populations. These studies will generate novel preclinical sex hormone-altered pharmacological models. This project may identify new insights into those susceptible to developing chronic postoperative pain as well as a greater understanding into underlying genetic and genomic mechanisms. Although many individuals with underlying altered sex hormone levels undergo surgical procedures, most preclinical studies do not attempt to address this highly relevant patient population. As it is well documented that sex hormones play pivotal roles in pain development and maintenance, this is striking. In particular, the role of basally altered sex hormones in gonad-intact preclinical post-surgical pain models is relatively unknown and understudied. Furthermore, the genome-wide and tissue-specific genetic changes that sex hormone alterations may produce before, during, and after surgery have yet to be elucidated. Precise manipulation of hormone levels to establish chronic post-surgical pain causation is not possible in humans. To identify targets for improved post-surgical recovery we will therefore take advantage of a clinically informed sex hormone altered rodent models as well as validated behavioral endpoints. Our central hypothesis is that within vulnerable patient populations, sex hormone alterations occur, contribute to changes in mood, and both sex hormone alterations and mood changes predispose those vulnerable individuals towards post-surgical chronic pain. To pursue this fundamental work, we will use a combination of molecular and whole organism approaches in which I have significant expertise including mouse models of incisional surgery, pain-evoked and pain-depressed behavioral readouts, as well as examination of fold-changes related to both the genome and specific tissues. This convergence of capabilities uniquely positions my independent laboratory to answer key knowledge gaps: 1) Sex hormones are critical in the development and maintenance of chronic pain, but can pharmacological modulation be monitored in vivo via pharmacokinetic measures to identify correlative pain-related behaviors? 2) What specific genetic alterations occur due to sex hormone alterations? 3) Are the sex hormone alterations seen within the surgical patient population relevant to the use and potency of post- surgical analgesics? Ultimately, these studies will establish how sex hormone alterations may influence post- surgical pain recovery. Successful completion of the proposed studies may enhance our understanding of sex hormone alterations within vulnerable patient populations, and the role of sex hormones on healing after surgery, identify associated -omics related changes, and clarify analgesic treatment options. PROJECT NARRATIVE Post-surgical pain is common amongst those recovering from a surgical procedure. However, a small but significant surgical population experience chronic post-surgical pain. Although it is generally understood that sex hormones contribute to the development and maintenance of pain, including chronic pain, little is known about the role that basal sex hormone alterations play in development and maintenance of chronic post- surgical pain or analgesic post-surgical pain management. The work proposed herein seeks to develop novel altered sex hormone models that mirror the surgical patient population, as well as elucidate antinociceptive profiles. | Non-SBIR/STTR | 6project_grants_public |
gen_47a67be66c4ed6d3cb7eb71942310dfb | A Non-Inferiority Randomized Single Blind Controlled Trial Comparing One and Two Dose Regimes of Oxfendazole versus a Two Dose Regime of Triclabendazole to Treat Chronic Fascioliasis | NIH | UNIVERSIDAD PERUANA CAYETANO HEREDIA | 1U01AI155323-01A1 | Oxfendazole in Fascioliasis Principal Investigators/Program Directors: GARCIA, Hector H./ CABADA, Miguel M. A Non-Inferiority Randomized Single Blind Controlled Trial Comparing One and Two Dose Regimes of Oxfendazole versus a Two Dose Regime of Triclabendazole to Treat Chronic Fascioliasis ABSTRACT Fasciola hepatica infection causes human liver disease in wide endemic regions around the world. Triclabendazole is the only effective drug to treat human fascioliasis. However, it is not widely available and recently reports about resistance in livestock and decreased efficacy in humans raise concerns for the availability of effective treatment in human infections. Triclabendazole (TCBZ) resistance in human has been reported in The Netherlands, Turkey, Chile, Portugal, and Peru. In our experience in Cusco, Peru, more than 40% of children treated with one triclabendazole dose failed to achieve parasitological cure and 60% of these failed a second dose of treatment. Oxfendazole (OXF) is a veterinary benzimidazole with a wide anti-helminthic spectrum. Our group has demonstrated that OXF is highly efficacious against Taenia solium cysticercosis and other helminths. A preliminary study in naturally infected sheep showed that OXF is also highly efficacious against Fasciola hepatica. We have completed animal toxicology and phase 1 OXF studies in humans, confirming the high bioavailability of OXF and, importantly, its safety. These data strongly suggest that OXF is an excellent candidate for the treatment of human fascioliasis. Therefore, we propose to compare two oral OXF treatment regimens, a single 20 mg/kg dose and two 20 mg/kg doses, against the standard of care of two 10 mg/kg oral doses of TCBZ for the treatment of 336 children and adults with chronic Fasciola hepatica infection in endemic areas of Cusco, Peru. In addition, population PK modeling will be performed among subjects randomized to the OXF arms. This study will evaluate the efficacy, safety, and population pharmacokinetics of OXF in the groups most affected by fascioliasis. This application builds upon our 25-years of experience working with OXF and takes advantage of the solid expertise of the PIs in helminth infections, prior pivotal randomized clinical trials of anti- parasitic treatment in cysticercosis, and our continued work in a well-known Fasciola-endemic region in the Andes Mountains of Cusco. The investigators supported by the Oxfendazole Development Group will form a multidisciplinary team of accomplished experts in fascioliasis, field epidemiology, clinical trials, and new drug development that will ensure the successful completion of this study. This trial has the potential to provide a new standard of care for the treatment of chronic fascioliasis. In addition, it will be the first evaluation of OXF efficacy for a human tissue parasite and constitutes a significant step forward towards making this promising drug available for the treatment of human. It will provide additional pharmacokinetic and safety data to advance OXF development as a human drug. Oxfendazole in Fascioliasis Principal Investigators/Program Directors: GARCIA, Hector H./ CABADA, Miguel M. A Non-Inferiority Randomized Single Blind Controlled Trial Comparing One and Two Dose Regimes of Oxfendazole versus a Two Dose Regime of Triclabendazole to Treat Chronic Fascioliasis PROJECT NARRATIVE Fasciola hepatica infection causes liver disease in endemic regions, affecting between 2.6 and 17 million people around the world. Treatment is suboptimal. Triclabendazole, the only highly effective drug, is not widely available, and there is concern for the spread of resistant infections in humans. Oxfendazole is a veterinary benzimidazole with a wide anti-helminthic spectrum, highly effective against Fasciola, but it has not yet been evaluated in humans. We have completed animal toxicology and phase I studies of oxfendazole in humans, confirming its high bioavailability and, importantly, safety. We will compare two oral oxfendazole regimens, a single 20 mg/kg dose and two 20 mg/kg doses, against the standard of care of two 10 mg/kg oral doses of triclabendazole for the treatment of human fascioliasis. This study will be the first efficacy evaluation of oxfendazole in a tissue parasite of humans, and a significant step forward towards making this promising drug available for treatment of human parasitic infections. This resubmission address the reviewer’s comments and presents a comprehensive discussion of the study procedures. | Non-SBIR/STTR | 6project_grants_public |
gen_7dd745c7c39751f5b0719d6bf6f5a6dc | Does NHANES underestimate true population-based exposures to pesticides? Exploring bias in NHANES human biomonitoring data. | NIH | EMORY UNIVERSITY | 5R03ES035184-02 | SUMMARY/ABSTRACT Human biomonitoring (HBM) – the measurement of a chemical, its reaction product, or metabolite in biosamples – is an exposure assessment technique that is often considered the “gold standard” in exposure assessment. The US uses the National Health and Nutrition Examination Survey (NHANES) as a vehicle for sample collection for its national HBM program. NHANES data collection occurs in Mobile Examination Centers (MEC), large trailers containing a mobile laboratory. Scheduling site locations for data collection includes considerations such as seasonal weather patterns and difficulties with MEC unit transit. Because MEC units cannot easily traverse difficult roadways with snow and ice patching, logistics require that sampling in areas often hit with harsh winter weather occur during the warmer months (i.e., spring and summer) whereas more temperate locations can be sampled in cooler months (i.e., winter and autumn). Given this, NHANES data that may vary by season could be subject to both temporal and spatial bias. This potential bias could, in turn, lead to inaccurate interpretations of population exposure and health data. We will evaluate any bias in HBM data of seasonal chemicals from NHANES using two specific aims. 1) Conduct state-level and seasonal evaluations of distributions of seasonal and non-seasonal chemical urinary biomarkers in NHANES Cycles 1999-2016 using the NCHS Research Data Center allowing access to restricted geocodes and sampling dates. 2) Compare NHANES state-level urinary pesticide metabolite data to smaller-scale biomonitoring studies conducted in different US states during different seasons. This study could provide information that will enable CDC to reconsider their sampling logistics to better represent seasonal and regional variations or will enable us to quantify the extent to which NHANES underestimates US population exposures. NARRATIVE This study will evaluate whether CDC’s National Health and Nutrition Examination Survey (NHANES) provides accurate population-based human biomonitoring levels for seasonal chemicals. It will provide information that will enable CDC to reconsider their sampling logistics to better represent seasonal and regional variations or will enable us to quantify the extent to which NHANES underestimates US population exposures. This, in turn, will make it possible to apply a multiplicative factor to future exposure estimates from NHANES to obtain a more accurate assessment of exposure. | Non-SBIR/STTR | 6project_grants_public |
gen_7c8c7290ddedb98c76c8969ec7c5291d | Evaluating the role of multimorbidity in modulation medication effects in older adults | NIH | RUTGERS BIOMEDICAL AND HEALTH SCIENCES | 5R01HL163163-02 | Multimorbidity, defined as the co-occurrence of two or more medical conditions, impacts two-thirds of older individuals over 65 – corresponding to 36 million U.S. adults, and is a major driver of healthcare spending, polypharmacy, and mortality. However, the routine exclusion of older and more multimorbid patients from clinical trials has resulted in the paucity of data regarding the risks and benefits of medications in this population, or an understanding of how multimorbidity alters treatment effects. To address this unmet need, this proposal will evaluate the role of multimorbidity in modulating medication effects and identify the optimal approach that best quantifies its impact on medication outcomes. Our central hypothesis is that (a) by attenuating drug-related benefits and amplifying drug-related harms, multimorbidity should be a key consideration when making treatment decisions, and that (b) approaches that incorporate the cumulative burden of illness – especially the multi- morbidity weighted index [MWI] – can better characterize these alterations in medication effects (preliminary analysis). The proposal will use Medicare fee-for-service data from >23 million patients and replicate findings in two large external databases. We will focus on cardiometabolic therapies as: older adults have the highest burden of these conditions, and since 2010, more than 20 new cardiometabolic therapies have been approved, highlighting the immense need to study these medications. We will identify patients with: (a) type 2 diabetes initiating sodium glucose co-transporter 2 inhibitors vs established antidiabetic therapies; (b) atrial fibrillation initiating direct oral anticoagulants vs warfarin; and (c) atherosclerotic cardiovascular disease [CVD] initiating newer antiplatelet drugs (e.g. ticagrelor) vs clopidogrel. Aim 1 will evaluate how clinical (e.g. cognitive impairment) and non-clinical (e.g. social deprivation) factors interact with multimorbidity to influence medication prescribing of cardiometabolic therapies in the real world. Aim 2 will elucidate the role of multimorbidity in modulating the risks and benefits for newer compared to established cardiometabolic medications by estimating the adjusted rates of disease specific benefits (i.e. reduction in CVD events), harms (e.g. major bleeding) and universal outcome measures (e.g. home-time, loss of functional independence) by levels of multimorbidity. We will also validate multimorbidity measures (e.g. MWI, Elixhauser index) and frameworks (e.g. disease dyads) against medication outcomes. The impact of this proposal is significant as it will establish a rigorous and readily scalable framework to study the effects of multimorbidity on drug outcomes in older adults. It will also represent the first effort to systematically evaluate and validate multimorbidity indices and approaches against medication outcomes, beginning a new and exciting line of research that has potential to expand to other populations (e.g. middle-aged adults) and clinical areas. Given the paucity of data from clinical trials, study findings will serve as the primary source of information for patients, caregivers, and clinicians to make individualized evidence-based decisions. Although multimorbidity affects >36 million older adults in the US, there is a paucity of data to guide medication prescribing by multimorbidity burden. This proposal will leverage high-quality data and innovative methods to evaluate the impact of multimorbidity on modulating the safety and effectiveness of cardiometabolic therapies among older adults. Study findings will help patients, caregivers, and clinicians to make individualized evidence- based treatment decisions | Non-SBIR/STTR | 6project_grants_public |
gen_b840628da54942709b08f1a302f971a6 | Mechanism for post-transcriptional gene regulation by Ribothrypsis | NIH | THOMAS JEFFERSON UNIVERSITY | 1R01GM149825-01 | PROJECT SUMMARY/ ABSTRACT Post-transcriptional regulation of gene expression is fundamental to normal cellular homeostasis. The current model in the field of biology is that mRNAs exist primarily as ‘full-length’ molecules that are ‘protected’ from decay by ribosomes during translation. The long-established understanding is that mRNA decay is initiated by deadenylation followed by decapping and subsequent exonucleolytic decay from both ends. Co-translational mRNA decay is known to occur mainly in defective mRNAs. Existing next-generation sequencing methods that profile mRNA decay target either the 5’ or 3’ ends, thus missing information about the other end that could illuminate new insights into mRNA decay. During my post-doctoral training, I developed several novel transcriptome-wide sequencing methods that concurrently select both ends of mRNAs. I discovered a novel mechanism of co-translational decay of canonical mRNAs that involves repeated endonucleolytic cleavage events, mediated by translating ribosomes that we named “ribothrypsis”. Ribothrypsis is conserved between humans and yeast. We identified the unexpected ribosome-phased mRNAs fragmentation and found that deadenylation is not a prerequisite for mRNA decay. Our discovery of ribothrypsis revealed that co-translational mRNA decay is more widespread than previously thought. The central hypothesis of this proposal is that ribothrypsis is an evolutionarily conserved mechanism for modulating gene expression that can be triggered by numerous factors to recruit an unknown endonuclease that we termed “ribothrypsin”. We propose here to capitalize on our past discoveries and leverage cutting-edge novel RNA sequencing methods to achieve a comprehensive understanding of the mechanistic underpinnings of ribothrypsis and its regulation. In this proposal, we will investigate (i) the impact of cellular conditions that induce ribosome stalling on RNA decay intermediates; (ii) the conservation of ribothrypsis in other eukaryotes; (iii) the identity of ribothrypsin; and (iv) the role of RNA modifications in triggering ribothrypsis. These goals are mirrored by our long-term objective to understand the mechanisms that underlie RNA decay dysregulation in human diseases. The molecular insights gained in this proposal could also broaden our understanding of ribosome biology and RNA modifications. NARRATIVE RNA decay is critical for proper cellular functions and homeostasis. In this proposal, we exploit novel RNA sequencing methods to develop a mechanistic understanding of a conserved biological mechanism of co- translational mRNA decay known as “ribothrypsis”. Deciphering the biology of ribothrypsis will enhance our understanding of how gene dysregulation underlies human diseases, paving the way to the development of new RNA-based diagnostics. | Non-SBIR/STTR | 6project_grants_public |
gen_f16af5d64261b48ec710b5febf1dd5fe | Reversing Drug Resistance in Tumors with Clickable Antibody Pairs | NIH | WASHINGTON UNIVERSITY | 1R37CA276498-01 | PROJECT SUMMARY/ABSTRACT – The incidence of gastric and breast cancers is increasing rapidly, rating fourth and fifth leading causes of cancer mortality worldwide. In patients clinically classified as HER2-positive (ERBB2 amplification and/or 2+/3+ protein overexpression by immunohistochemistry), antibody-drug conjugates (ADC) prolong progression-free and overall survival. However, these therapies have low activity in HER2-low cancer cells, and not all HER2-positive tumors benefit, or even those who initially respond inevitably develop resistance over time. Guided by preclinical data we obtained in HER2 heterogeneous patient-derived xenografts demonstrating that an increase in HER-ADC endocytosis enhances therapeutic efficacy, we developed approaches of antibody delivery that result in a 15.5-fold increase of ADC internalization in cancer cells. Our novel approach uses pertuzumab and trastuzumab-drug antibodies that click at the surface of cancer cells upon binding distinct HER2 domains to increase the number of HER2-ADC complexes and further enhance the rate of HER2-ADC endocytosis. Antibody-PET imaging studies that we have generated demonstrate that our approach increases the uptake of 89Zr-ADC in heterogeneous tumors containing HER2-high and HER2-low cancer cells. Here, we will optimize clickable pairs of two epitope-distinct antibody-ADC biomolecules to enhance tumor targeting and drug delivery in resistant models of breast and gastric cancer. In addition to test the potential of our approach in cancer cell lines and organoids, we will perform randomized imaging and therapeutic studies in patient-derived breast and gastric xenografts representing three tumor populations: ADC-eligible tumors of HER2 heterogeneity, ADC-ineligible tumors, and ADC-resistant tumors. We will determine the molecular imaging (89Zr-Antibody PET), safety, pharmacokinetic profile, and therapeutic efficacy of ADC alone (no-click) versus ADC plus pertuzumab conjugated with clicking pairs (click). These randomized preclinical studies will allow us to identify molecular features that confer drug sensitivity or resistance to this promising investigational approach. Aim 1 will optimize pertuzumab/ADC clicking pairs with improved tumor uptake and drug delivery when compared with ADC monotherapies and Aim 2 will validate the use of antibody clicking pairs as a new therapeutic approach. The two aims will provide important new preclinical data on the use of antibody clicking pairs to enhance drug delivery, which could provide an excellent foundation for many future investigations, including the clinical translation of using clicking pairs to enhance drug delivery and the potential broader application to other membrane receptors and heterogeneous tumors. The long-term translational objectives of the studies proposed are to establish a foundation for a clinical trial using antibody clicking to prevent or delay drug resistance in patients with heterogeneous breast and gastric cancers. PROJECT NARRATIVE – The vast majority of patients with HER2-positive breast and gastric cancers become refractory to anti-HER2 antibody-drug therapies, and HER2-negative or several other non-breast/non-gastric tumors do not respond to classical anti-HER2 therapy. We found that methodologies increasing the internalization rates of the HER2 receptor can be exploited by antibody-drug conjugates to effectively treat heterogeneous HER2 diseases. This proposal seeks to optimize a methodology of antibody-drug internalization to overcome drug resistance in HER2-positive and HER2-negative tumors. | Non-SBIR/STTR | 6project_grants_public |
gen_e52e343495a240bcd9d3673e7e06f682 | FEDER - UNICAEN (EVA LAB) - SMN PROJECT | Kohesio | UNIVERSITE DE CAEN NORMANDIE | https://linkedopendata.eu/entity/Q3680317 | Having become a national priority, the desire to recreate "a protein sovereignty of Europe" and to "Grow more soy in France to feed livestock and thus avoid importing GMO soy" was reaffirmed very recently by President Emmanuel Macron, at the G7 summit which was held on August 29, 2019. Faced with the increase in demand for proteins intended for animal and human food (vegetarian and vegan diet), the development of the culture of oilseeds (soy, rapeseed, sunflower, pea, fava bean, lupine, flax, etc.) represents a major challenge. Thus, the development of new extractability processes on oilseeds allows, from the meal (residue obtained after oil extraction), the production of protein isolates with functional profiles optimized for several (i) food applications (tofu, tempeh, vegetable steak, mayonnaise, bakery products, vegetable juice/milk, fermented products, etc.) (Ali 2010; Von Der Haar et al. 2014) and (ii) non-food with high added value in various industrial sectors, particularly in green chemistry (protein concentrate or isolate with high emulsifying or foaming capacity, bio-sourced materials, etc.). The global production of oilseeds has seen considerable growth over the last 20 years, with in particular a doubling of soybean production to reach nearly 360 MnT in 2018 (source: FAO stats). The European Union imports 17 million tonnes (Mt) of crude vegetable proteins (soy, pulses, sunflower, etc.) each year, of which 13 Mt are based on largely GMO soy. | Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking | 6project_grants_public |
gen_b0953ec6b99723d2ed680e886f450ce5 | FEDER - UNICAEN (ISTS and COMETE LABOS) - PEPSY PROJECT | Kohesio | UNIVERSITE DE CAEN NORMANDIE | https://linkedopendata.eu/entity/Q3673414 | Schizophrenia is a common mental illness (1%) beginning in young adults and which represents a heavy burden for patients, their loved ones, the health system, the social and medico-social system and society in general. It is considered by the WHO to be the eighth cause of disability among 15 to 44 year olds. Its cost for the health system represents 1.1% of national health expenditure and 120/000 of the gross domestic product (GDP). People suffering from schizophrenia are very sedentary and have risk factors causing excess mortality (life expectancy reduced by 10 to 15 years). In fact, these patients have, compared to the general population, higher rates of obesity, diabetes, hypercholesterolemia and cardiovascular diseases (heart attacks, arrhythmia, high blood pressure). They also have cognitive disorders (memory and learning deficits, deficits in establishing action plans) leading to social and professional disintegration. The search for therapies complementary to usual treatment (antipsychotics), acting on these risk factors and these cognitive deficits, is a real challenge. Among these therapies, Adapted Physical Activity (APA) capable of acting on these two aspects should have a considerable impact in terms of the well-being of the person, the prevention of risk factors and health costs. This project will focus on the effects of Adapted Physical Activity (APA) on the health of schizophrenia patients. It will consist of: 1- setting up an innovative teaching method (first in the field) and adapted to this audience (e-coaching or distance coaching) thanks to the expertise of the company V@SI; 2- to demonstrate the effectiveness of such therapy on the mental health (well-being, quality of life), physical health (metabolic, cardiac, cerebral) and cognitive functions (particularly memory) of patients suffering from schizophrenia, 3- to evaluate, thanks to the expertise of the company BodyCap, the impact of this therapy on the 24-hour biological rhythms (temperature, sleep/wake cycle) known to be disrupted in these patients; 4- to develop a computer interface allowing continuous and remote monitoring of heart rate during APA thanks to the expertise of the company Ob'do (essential for these patients receiving medications likely to modify their heart rate). This project will lead to the development and dissemination of this remote APA therapy at the regional and then national level for patients suffering from schizophrenia but also other disorders such as depression and addictions causing sedentary lifestyle and social isolation. | Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking | 6project_grants_public |
gen_3a5c57f84d6bc641b3a1f79431a6ee2e | FEDER - URN - PHASME - EMERGENT | Kohesio | UNIVERSITE DE ROUEN-NORMANDIE | https://linkedopendata.eu/entity/Q3681620 | Polymer-based membranes are used in many sectors of activity due to their variability of function, their modularity and their performance/cost ratio. Thus, membrane systems are experiencing very significant growth for various applications ranging from separation and filtration (reverse osmosis, nanofiltration, dialysis) to biomedical (dressing, implant) and tissue engineering, including cosmetics, galenics, agri-food, transport and energy (hydrogen fuel cells). One of the current challenges for organic membranes is to achieve better performance in terms of barriers and/or selectivity while maintaining good thermomechanical qualities and durability. The Polymer Barrier Materials and Membranes (MPBM) team is recognized for its expertise in the development of original and promising solutions to meet this challenge. Today, membranes presenting properties that can be modulated via an external stimulus (temperature, pH, pressure, steam, light, etc.) are of particular interest for the development of functional systems with reversible properties with high selectivity. This axis, not yet exploited in the MPBM team, opens new perspectives towards multiple applications, notably in microfluidics, controlled release of an active ingredient, biomolecular analyses, detection of VOCs, intelligent textiles, sensors. Light has obvious advantages for dynamically controlling the transfer of matter. Indeed, it is a rapid, neutral, local (at the nanometer scale) and reversible external stimulus. The objective of the project is to develop new porous membranes with photosensitive properties. The pores of the membrane will be chemically modified by grafting an object of interest (polymer chains, micelles, proteins, etc.) via a photosensitive group (azobenzene, nitrobenzyl). The presence of the photosensitive group between the surface of the cavities and the object of interest will allow, in the case of a photolabile group (nitrobenzyl), the release of an object of interest (micelles) or in the case of a photosensitive group (azobenzene) access to significant variations in pore diameter and thus be able to modulate significantly the flow of small diffusing species. | Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking | 6project_grants_public |
gen_3e5086b6ee736ec9647b4d2c20088b71 | FEDER - ROUEN NORMANDY UNIVERSITY (GLYCOMEV LAB) - SMN PROJECT | Kohesio | UNIVERSITE DE ROUEN-NORMANDIE | https://linkedopendata.eu/entity/Q3681711 | Faced with the increase in demand for proteins intended for animal and human food (vegetarian and vegan diet), the development of the cultivation of oilseeds (soybean, rapeseed, sunflower, pea, faba bean, lupine, flax, etc.) represents a major challenge. The world production of oilseeds has experienced considerable growth over the last 20 years, with in particular a doubling of the production of soybeans to reach nearly 360 MnT in 2018. The European Union imports each year 17 million tonnes (Mt) of crude vegetable proteins (soybeans, pulses, sunflowers, etc.), of which 13 Mt are based on largely GMO soybeans. At the national level, oilseed crops cover 2.6 million ha in 2018, or around 22% of the usable agricultural area (UAA) in mainland France. Regionally, in 2017, Normandy produced 570, 73, and 37 thousand tons of rapeseed, peas, and beans, respectively. Despite relatively large areas of oilseed and protein crops, France imports most of its soybean needs from the American continent. Thus, in 2018, it was estimated that more than two thirds of soybeans used in France came from imports. Having remained marginal for a long time, soybean cultivation is experiencing strong growth in France with areas quadrupling between 2013 (42,000 ha) and 2018 (154,000 ha) for production which currently reaches 400,000 tonnes, in particular thanks to the appearance of early varieties that can adapt to various pedoclimatic contexts. In France, the food outlets for soybean meal are divided into 80% for animal feed and 20% for human food. The aerial and root parts also represent a strong potential in terms of green manure and animal fodder. This legume presents good agronomic performances due to its numerous physiological advantages and a model well suited to cultivation in organic agriculture. In April 2018, the inter-professional association launched a “Soja de France” charter which is based on four commitments: French origin, local crops and non-GMO products, guaranteed traceability from the seed to the processed soy product, and sustainability criteria. Terres Univia hopes that 50% of the 650,000 t of seeds planned for 2025 will be produced under this label. Even if the historic basins (South-West and Burgundy) remain predominant, the soybean cultivation area is expanding, thanks to the recent registration of early and very early varieties which make it possible to introduce this high-potential crop into the agricultural regions of the North/West of France. Thus in Normandy, some soybean cultivation trials have been implemented in recent years. Despite these initiatives, there remain many obstacles to the development of this crop in our region to achieve the targeted yield and protein quality objectives: the choice of variety, securing the establishment of the crop and determining the agronomic levers linked to the specific Norman pedoclimatic context. It is in this context that the Soja Made in Normandy (SMN) project falls. | Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking | 6project_grants_public |
gen_36817d77cac573e6f7adccaf64bda808 | FEDER - UNICAEN - OA-ACTIVE - SPRINGBOARD | Kohesio | UNIVERSITE DE CAEN NORMANDIE | https://linkedopendata.eu/entity/Q3680453 | Since its first description in 1938 by Callender and Kelser, equine osteoarthritis has been compared to its counterpart in humans. Since then, the horse has been considered the most relevant animal model for the study of this degenerative pathology on the basis of the structural/biochemical properties of the cartilage, its locomotor capacities, but also on that of the evolution of this syndrome associated with a progressive destruction of the cartilage, bone modifications and surrounding tissues constituting the joint. Thus, in humans as in horses, osteoarthritis develops following abnormal stresses on normal cartilage (traumatic or fatigue lesions) or following normal stresses on abnormal cartilage (age in particular) and is secondarily associated with a strong inflammatory component. These constraints occur throughout the life of both humans and horses, whether they are athletes or not, and involve all of the tissues constituting the musculoskeletal system. Among these tissues, cartilage, which is not vascularized, has a very low repair capacity. Consequently, traumatic and degenerative lesions of the articular cartilage inevitably evolve into osteoarthritis linked to uncontrolled molecular mechanisms at the origin of metabolic and biomechanical disturbances of the joint. Currently, no treatment can prevent this progressive course of the disease. The available treatments are only palliative (reduction of pain/inflammation and discomfort and at best slowing down of the degenerative process) and lead in the final stages of the pathology in humans to the installation of prostheses. Osteoarthritis, due to the synergy of biological/biochemical and biomechanical alterations, remains a difficult disease to treat. No non-surgical treatment allowing cartilage regeneration currently exists. It is in this context that the interest in the development of cartilage regenerative medicine strategies based on the use of functionalized hydrogels for biological and mechanical actions combined or not ultimately with the secretome of mesenchymal stem cells for their anti-inflammatory and pro-regenerative actions emerges. | Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking | 6project_grants_public |
gen_2984696a5afe023234d9754b01302876 | FEDER - INSA - INCA | Kohesio | INSTITUT NATIO SCIENCES APPLIQUEES ROUEN | https://linkedopendata.eu/entity/Q3681596 | The explosion in the number of connected objects, assistant robots and intuitive and natural human-machine interfaces has enabled an increasing democratization of cyber-physical and socio-technical systems. These are systems made up of human users, robots and artificial agents in social interactions. If the democratization of these tools is a major element for new daily services, its diffusion comes up against two main obstacles: on the one hand, the recognition of human activity remains imprecise, both at the operational level (location, mapping, identification of objects and users) and cognitive (recognition and intention tracking). On the other hand, the interaction passes through different vectors which must be adapted depending on the context (robotics, mixed reality, virtual reality), the user and the current task situation. The scientific obstacles questioned by the INCA project are divided into two distinct applications and a transversal problem. The first concerns the design and evaluation of virtual and mixed environments for learning, to assess the impact of conversational agents within immersive and interactive simulations. The second axis questions issues specific to robotics: the perception of the environment and the representation of spatio-temporal knowledge for social interaction and navigation. Finally, the problem of managing mixed-initiative social dialogues with users is common to these two applications. Thus, the INCA project aims to perceive and represent an environment in order to reason about it, to interact in a natural and social way with users and to learn a user model in order to adapt the interactive behavior of agents. | Smarter Europe / Research and innovation / Research and innovation infrastructure (public) | 6project_grants_public |
gen_f2c2a0464e14dbfa8ac5aea18222399f | FEDER - ROUEN NORMANDY UNIVERSITY (GLYCOMEV LAB) - DRAGONE PROJECT | Kohesio | UNIVERSITE DE ROUEN-NORMANDIE | https://linkedopendata.eu/entity/Q3681365 | In recent years, the French agricultural model has gradually shifted towards sustainable and reasoned agriculture with the objective of improving food security and preserving the environment. This change also involves the development of integrated biological crop protection. In this context, it is appropriate to anticipate these developments and therefore to conduct research aimed at identifying and developing new plant protection strategies. These strategies are part of the national Ecophyto plan to reduce pesticide use by 50% in France. The “DRAgoNE” project is part of this change. This is a public-private collaborative project which aims to promote the skills in fundamental and applied research in plant sciences of a Norman research laboratory (GlycoMEV) and to enable their transfer to the regional, national and global industrial fabric through collaboration with the Roullier Group. This industrial partner is now present in 116 countries. The Roullier Group is a large company specializing in plant nutrition and animal nutrition. The GlycoMEV laboratory (Glycobiology and plant extracellular matrix) is a Normandy Universities laboratory specializing in plant sciences whose activity is focused on the study of the structure and function of parietal polysaccharides and glycoproteins, plant defense at the root level, the search for new defense stimulators against soil-borne pathogens and the understanding of plant-bioaggressor interactions. This project builds on the strong collaboration already existing between these two partners for many years through joint projects and scientific exchanges. It represents a real opportunity for the Normandy region in terms of developing public and private R&D skills, industrial and scientific influence, employment and training. Its ambition is to develop a collaborative and innovative scientific activity between the laboratory and the company in order to: i) promote agroecology in plant production in connection with the ECOPHYTO plans, ii) characterize the elements of a complex root network and their synergistic action in the protection of plants in pathosystems of global agronomic interest, ii) to promote the fundamental knowledge acquired on this root network by identifying active substances and diagnostic tools transferable by the company in the industrial sector in connection with the plant sectors in order to increase the attractiveness of the Normandy territory. The choice of the pathosystems studied in this project is based on i) the heavy economic losses (quantified in millions of tonnes/year), ii) the interest of the industrial partner in developing new bio-control products, and iii) the agricultural issues in the Normandy Region. Thus, several types of pests (including nematodes plant parasites but also microorganisms), will be used as part of this project. The plant species chosen are Solanum lycopersicum L. (tomato), Beta vulgaris L. (beet), Linum usitatissimum (flax) or Glycine max (L.) Merr. (soy). The proof of concept will be carried out on model plants (arabidopsis, tomato or soybean). Application to plants of economic interest will take place subsequently. The project will also focus on stimulating the immune defense of the plant tested through the use of defense response elicitors from nematodes (NAMPs) and formulations of active substances previously identified by the work of the Roullier group. | Smarter Europe / Research and innovation / Research and innovation infrastructure, processes, technology transfer and cooperation in enterprises focusing on the low carbon economy and on resilience to climate change | 6project_grants_public |
gen_933a4dea3ebcf34ddecce8d86082e00e | Flexible smart surfaces for augmented indoor communications | Kohesio | ESIGELEC | https://linkedopendata.eu/entity/Q4297783 | Interest in communications devices (CDs) is growing rapidly due to the important yet essential services they offer such as Internet, wireless healthcare, home automation, wireless access control systems, alarms, etc. Thanks to their advantages, the future of CDs is still bright as the market is growing at double digits per year with 18 billion devices predicted and worth $1.2 trillion by 2022. Such an increase in devices is expected to lead to high energy demand. For example, in the France (Canal) England (FCE) zone, the current usage of smoke detectors is approximately 5.6 million and 7.9 million devices in France and the United Kingdom respectively. This corresponds to more than 5.3 MWh and 7.4 MWh respectively in annual consumption. Another example concerns Wi-Fi routers/boosters estimated at more than 95,000 and 130,000 devices on the French and British sides respectively, which leads to annual consumption of more than 2.5 GWh and 3.4 GWh. Additional CDs (alarms, detectors, sensors, etc.) further increase the energy bill on both sides of the canal. Providing disruptive energy-efficient solutions to power future DCs is the common challenge of the FCE zone that this project is intended to address. The goal is to design a power-free electronic surface capable of optimally focusing ambient electromagnetic (EM) waves onto the appropriate receiver to enable both self-powered CDs and improve their performance (sensitivity, range, speed). Such a system is new and missing on the market. It is expected to reduce the energy bill of the FCE zone by more than 5.9 GWh per year, while saving 14.9 million euros considering (but not limited to) applications on Wi-Fi boosters and smoke detectors. For these targeted applications, two prototypes will be designed, manufactured, experimentally tested, validated on two demonstrators and transferred to interested SMEs (more than 217 in the FCE zone) developing different types of CDs. The first prototype will increase the power supply (lifetime) harvested from ambient waves over the ISM/GSM/3G/Wi-Fi bands to enable autonomous EM-based devices such as smoke detectors, detectors, sensors, etc. The second prototype will increase the range of Wi-Fi signals without consuming additional power unlike common Wi-Fi boosters. The specifications (costs, performances, etc.) and validation of the two prototypes will be carried out by GST, already marketing autonomous sensors (solar-based). Manufacturing tasks will be carried out on the UK side by IML and UoS, skilled in the manufacture of small and large area electronic boards. The design skills will be fulfilled by ESIGELEC on low frequency bands (ISM/GSM/3G/Wi-Fi-2.4GHz), and by UoK for higher bands (Wi-Fi-5/60GHz). In order to trigger the deployment of future products, the results will be promoted, disseminated and transferred to SMEs throughout the FCE zone by the partnership, led by the business consultant (Projaction) on the France side and by IML on the UK side. | Not available / Not available | 6project_grants_public |
gen_830574d6df11eaf43040be8822153627 | FEDER - CNRS - API | Kohesio | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE | https://linkedopendata.eu/entity/Q3681908 | Over the last twenty years, the production of intermediates or pharmaceutical active ingredients - most of which have fallen into the public domain - has been overwhelmingly outsourced to Asian countries for cost reasons intrinsically linked to the batch production method of these compounds. Indeed, the use of batch reactors means that to produce more you necessarily need reactors of greater capacity, and therefore very high investment costs, leading to the dismantling of the pharmaceutical production tool in France and Europe. However, today there is an alternative to this batch production: portable flow reactors. Where traditional batch production requires very large installations, flow synthesis uses a production tool the size of a household appliance. This “miniature factory” is both modular and mobile, allowing different pharmaceutical principles to be prepared on different sites according to local needs. In addition, such systems offer an innovative link between chemical synthesis and the design of autonomous factories. While flow chemical synthesis is booming on the international scene (MIT, Cambridge, Graz, Montreal and Kyoto), it still lacks visibility in France. It is in this context that the COBRA UMR 6014 laboratory has established itself as an emerging national player, and today wishes to use the expertise of its teams to initiate in the Normandy Region an ambitious research program dedicated to the pharmaceutical independence of the Normandy territory and transposable to the national scale: the ‘Pharmaceutical and Industrial Autonomy’ (API) project. | Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking | 6project_grants_public |
gen_7b3abb54f1bed2cd68ca7077b8563c55 | FEDER - UNICAEN - ALBATOR - EMERGING | Kohesio | UNIVERSITE DE CAEN NORMANDIE | https://linkedopendata.eu/entity/Q3680407 | has. Research objectives and hypothesesa.1. Agro-environmental context and impact of climate change on the grain quality of oilseeds and proteins Climate change affects the crop cycle during the reproductive phase and it is estimated that 30% of interannual yield variations of the main field crops result from variations in temperature and precipitation (Lobell and Field 2007; Ray et al. 2015). Furthermore, climate projections from different models and scenarios suggest an increased increase in extreme one-off events such as heat waves (Lemonsu et al. 2014; Trnka et al. 2014; Christidis et al. 2015; Bador et al. 2017). These trends are expected in the local Norman context and will be characterized more particularly by an increase in the frequency of drought episodes resulting from a reduction in precipitation and a strengthening of seasonal contrasts (Beauvais, 2016; Foissard et al., 2012). Based on this observation, the adaptation of crops to these climatic disturbances has become a priority issue for agriculture to guarantee food security and maintain or even improve the quality of products. In France, oilseed cultivation represents 2.3 million ha, or 20% of the UAA. On a regional scale, rapeseed (Brassica napus L.) is the 2nd largest production in Normandy (ca. 132,000 ha) after soft wheat and the 1st oilseed crop with 537,500 tonnes for the 2016/17 campaign (France AgriMer). Although the national and regional production of oilseed flax (Linum usitatissimum L.) is more confidential, the areas cultivated in France represent 22,000 ha (sources Terres Univia), ranking the crop second in the EU, behind England's 26,000 ha (FAO stat, 2017). In Normandy, flax production ranks 3rd (220 ha, 616t, 2015/16 campaign) among oilseeds behind rapeseed and sunflower; These two oilseeds are mainly exploited for the production of seeds particularly rich in oil (ca. 38-47% and 35-45% of the dry weight for rapeseed and flax respectively, Terres Inovia). Rapeseed oil is renowned for its high content of a-linolenic acid (¿3), an essential fatty acid and highly beneficial for food (9% for rapeseed; for comparison: 4% for soya; <1% for sunflower, (Aguirrezábal et al. 2015)). It is also used for the production of biofuel (Biodiesel®) and by-products linked to the growth of green chemistry sectors (lubricants, detergents, cosmetics, etc.). Furthermore, rapeseed meal, a by-product of seed crushing particularly rich in proteins and micronutrients, has become an outlet whose increasing value makes it possible to meet protein needs for animal feed while limiting dependence on imports of soybean meals (source: Terres Univia). The major interest of oilseed flax lies in the use of the seeds for animal feed. The oil is rich in triacylglycerides (38-40% for a raw seed at 9% humidity) (Hall et al., 2006) and more particularly in ¿3, (ca. 55%) (Labalette et al. 2011; Akhtar et al. 2013; Goyal et al. 2014). Interesting levels of ¿3 are found in meat products from animals fed on flax, a quality valued by the Blanc-Bleu-Cœur sector. However, the high content of a-linolenic acid makes it a delicate oil to preserve and controlling the fatty acid composition appears essential for the valorization of this resource. Flax cultivation also presents other agronomic uses (Nag et al. 2015). It allows diversification within crop successions by the introduction of a new species and a new family (Linaceae) and thus offers new outlets for farmers. [...] CF Annex attached. | Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking | 6project_grants_public |
gen_930ef216850bb7f5f23caf952d0cf4b7 | FEDER - UCBN - COACH-IPP Project (fct) | Kohesio | UNIVERSITE DE CAEN NORMANDIE | https://linkedopendata.eu/entity/Q3673478 | Ovarian cancer causes around 150,000 deaths each year worldwide, according to figures from the World Health Organization (WHO). In France, it affects around 4,500 women per year, and is responsible for more than 3,500 deaths per year in France; it has the lowest survival rate of all gynecological cancers and every woman can develop ovarian cancer, whatever her age, even if the average age is generally around 69 years. The introduction of new treatments and the evolution of protocols over the last thirty years have only slightly improved overall survival: ovarian cancer recurs and is generally incurable. The identification of chemoresistant patients and the development of new therapeutic strategies likely to overcome chemoresistance therefore constitute major challenges, recognized by health authorities. There is chemoresistance to the extent that the regulation of programmed cell death (or apoptosis) is impaired; the control of apoptosis is complicated and responds to different signals, mediated in particular by proteins, which interact with each other. Thus, the Bcl-2 family proteins are among the key players in the regulation of apoptosis. In this family we find anti-apoptotic members (like Bcl-xL or Mcl-1), and pro-apoptotic members. Thus, targeting anti-apoptotic molecules and neutralizing them is one of the possible strategies to restore apoptosis in cells and cause the death of cancer cells. Recently, our team developed a new molecule, called “pyridoclax,” capable of interacting with the Mcl-1 protein [Gloaguen, C.; Voisin-Chiret, A.S. et al. (2015) J.Med. Chem., 58, 1644; WO/2015/132727]. However, since the regulation of apoptosis is complex, this new molecule is not active alone. It needs to be administered with another molecule to exert its anticancer activity. Thus, it seems wise, for the continuation of our work, to design, using efficient physicochemical tools, new agents capable of interacting simultaneously with several proteins. Indeed, recent work by our partner has shown that the anti-apoptotic proteins Bcl-xL and Mcl-1 cooperate to protect ovarian cancer cells against apoptosis, and that their concomitant inhibition leads to the death of chemoresistant cells [Brotin et al. (2010) Int. J. Cancer, 126, 885]. The anti-apoptotic proteins Bcl-xL and Mcl-1 thus constitute an “essential molecular lock preventing the occurrence of apoptosis. Removing this barrier alone is sufficient to induce the death of chemoresistant tumor cells in response to oncogenic stress or chemotherapy. In this context, the discovery of dual-action inhibitors acting on Bcl-xL and Mcl-1 would be of major interest in the treatment of ovarian cancers that are highly refractory to conventional chemotherapy. Indeed, this concept of dual-action inhibitor offers numerous advantages in terms of therapeutic effectiveness by targeting several proteins of the apoptosis signaling pathways. In oncology, directing a therapeutic agent towards several targets (in limited number) constitutes a strategy for inducing cell death in a context of chemoresistance which is very advantageous compared to combinatorial therapies. | Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking | 6project_grants_public |
gen_1951ae85f7be36de643b2306e4f04058 | FEDER - CNRS - FAST-MIR et THERMOS - FONCT | Kohesio | EPST CNRS | https://linkedopendata.eu/entity/Q3673286 | This research project is part of the Research and Innovation Strategies for intelligent specialization (RIS 3) of the Lower Normandy region and more particularly in the field of sustainable and intelligent materials, which represents one of the 5 areas selected by the Lower Normandy region in consultation with local economic stakeholders. The FAST-MIR and THERMOS projects on which this request is based fit more precisely into the sub-area of specialization “Engineering and design of advanced materials which is among the 13 sub-areas identified following consultations between local economic players, representatives of research, businesses and institutions. The FAST-MIR project aims to develop innovative laser materials for ultra-short pulse laser sources operating in the mid-infrared, a wavelength range that is still little known. explored, but which presents strong application potential. The laser materials in question emit around 2m, the spectral range, in which the water absorption bands and the transmission windows of the atmosphere are located and which therefore can have applications in the processing of soft materials, laser metrology, free space communications or laser surgery and therapy. The production of laser sources emitting directly in the region around 2 m can be done from materials doped with thulium (Tm) and holmium (Ho) ions which are particularly attractive because of their high efficiencies and their wide gain bands around 2 m. These ions, already studied in different crystalline matrices and in fibers, have led to commercial lasers operating in continuous or Q-switched mode with powers reaching one kW and beams of very good quality at the diffraction limit. Interest in these ions now focuses on their operation in the ultra-short pulse regime. The potential of such sources in the femtosecond regime, around 2m, is indeed very great. Besides being an area of eye safety, the strong absorption of water in this wavelength range makes these sources very attractive for a number of medical applications, particularly in surgery. Furthermore, selective absorption by certain molecules (H2O, CO2, N2O, etc.) opens up perspectives for the study of the atmosphere with LIDAR-type techniques. In addition, ultrafast lasers emitting at 2 m are highly sought after for pumping OPOs emitting in the mid-IR, in the 3 m - 12 m range, for the generation of supercontinum in the IR, the production of THz sources and molecular spectroscopy. Finally, many other possibilities are available to these new laser sources such as the generation of XUV radiation or the creation of frequency combs in the MIR for metrology. The THERMOS project concerns the synthesis and physicochemical characterization of new hybrid thermoelectric materials intended to be used in a temperature range from ambient to 200°C. The synthesized materials will aim to replace bismuth telluride (Bi2Te3) which is to date the only material usable in this temperature range but this has the disadvantage of containing rare, expensive and toxic elements. Due to their chemical nature, hybrid materials are particularly well suited to low temperature applications. The strategy used to develop this project will consist of interposing organic molecules, insulating or conductive, into inorganic sheets of MS2 type (M=W, Mo, Ti) in order to combine high electrical conductivity and low thermal conductivity. | Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking | 6project_grants_public |
gen_eec3edeb4fd13582ae3d001a118652c3 | FEDER HN0005657 - UNIVERSITY OF ROUEN NORMANDY - AMED | Kohesio | UNIVERSITE DE ROUEN-NORMANDIE | https://linkedopendata.eu/entity/Q3681002 | AMED (Multidisciplinary Analysis of Domino Effects) is a structuring project at the regional level which develops a prospective multidisciplinary approach consistent with energy issues and future industrial developments in Normandy. The coupling of renewable electrical energy (ENR) from wind turbines (off and on shore) with nuclear production and the different fossil sources (coal, gas, oil) constitutes a complex whole with very varied dynamics and constraints to which are added the numerous sources of production by cogeneration and others energy recovery. It appears that power cuts due to random phenomena (natural causes, accidents, loss of control, etc.) can have cascading consequences on Norman industrial parks as well as on electricity transmission. The overall analysis of the operation of such a system in degraded mode, in non-operability, or even in phases of resilience, is crucial. It is necessary to measure the impact of these events, in particular on industrial parks and to study different scenarios causing the ungovernability or loss of control of sensitive systems. With the help of a specialist in domino effects, Professor Valerio Cozzani (DICAM from Bologna [Italy] world-renowned expert, more than 185 articles of rank A, Hirsch index higher 29), the AMED project was initiated. It concerns the study of domino effects in the context of mixed electricity supply (fossil and renewable). This theme emerged as a subject of interest, especially when considering the vulnerability of regional industrial parks after the multiple incidents of July 2015, depriving more than 150,000 homes of electricity and forcing 1,000 Renault employees into confinement. To develop the tools and methods, target processes were chosen in relation to future industrial developments in Normandy. The first target concerns processes using biomass as raw materials. Indeed, the reduction of fossil resources, environmental problems, global warming and the desire for independence from countries exporting fossil or nuclear energies are the various factors which favor the development of these processes. The second (linked to the first) is the chemical storage of electrical overproduction which in a context of decarbonation of human activities is a promising route. | Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking | 6project_grants_public |
gen_120c5c862dfed3af09bdd0cfee80effa | FEDER - INSERM - Cofin allocation - Rémi LAILLIER | Kohesio | EPA INSERM INSTITUT NAT DE LA SANTE ET DE LA RECHERCHE MEDICALE | https://linkedopendata.eu/entity/Q3673313 | Frontotemporal dementia and Huntington's disease are two neurodegenerative pathologies that cause damage to the behavioral sphere. Social behavior and interpersonal relationships are disrupted and one of the causal explanations proposed in this regard is that of disorders of social cognition. The present project aims to deepen the study of this cognitive domain to better understand these pathologies and potentially contribute to developing early neuropsychological markers in order to allow the most appropriate treatment possible. Both pathologies are accompanied by executive deficits centered on the capacities of cognitive flexibility, inhibition, control and planning. Memory difficulties are also observed in these two pathologies, even if they cannot be described as authentic, at an early stage of the disease, since the difficulties reside mainly in the ability to strategically retrieve information from memory and are therefore not attributable to an encoding dysfunction. Furthermore, if there are disorders of social behavior and interpersonal relationships in both pathologies, the nature of these disorders and their cause remain poorly understood today. However, they seem to have a more negative impact than motor and cognitive symptoms on the functional skills and quality of life of patients (Ho et al., 2009). Authors have recently suggested that the different behavioral symptoms inherent to these neurological conditions could be explained at least in part by alterations in social cognition, both in fronto-temporal dementia (Gregory et al., 2002) and in Huntington's disease (Allain et al., 2011; Snowden et al., 2003). This domain refers to the mastery of social knowledge, which is stored in semantic memory, the perception and processing of social signals, that is to say emotions, as well as the ability to represent the mental, cognitive and affective states of others, better known under the term theory of mind. Several studies have demonstrated impairment of these abilities in frontotemporal dementia. Furthermore, it has been shown that these patients have disorders in emotion perception (Torralva et al., 2009) and theory of mind (Le Bouc et al., 2012). The exploration of these social skills in Huntington's disease is rarer. Work on the perception of emotions has shown abnormalities from the presymptomatic stage of the disease (Henley et al., 2012). In addition, the rare studies carried out in Huntington's disease suggest the existence of cognitive and affective theory of mind disorders at a symptomatic stage of the disease whereas there would not be any at the presymptomatic stage (Saft et al., 2012) but further research is necessary. Finally, more generally, the mechanisms underlying these social cognition disorders are still poorly understood, as are the brain abnormalities responsible for them. Furthermore, the relationships between theory of mind processes, memory, and executive functioning are still subject to debate in the neuropsychological literature, and studies conducted to date do not provide a consensus to explain the nature of theory of mind disorders and social cognition more generally. This is even more true with regard to Huntington's disease due to the limited number of studies targeting this pathology. | Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking | 6project_grants_public |
gen_331f4d885c3372d9c681b814b8e07e38 | FEDER - URN - INFRA - EMERGENT | Kohesio | UNIVERSITE DE ROUEN-NORMANDIE | https://linkedopendata.eu/entity/Q3681618 | The study of wall biosynthesis is currently based on functional genomics. This strategy reaches its limits when the mutants are lethal or when one wishes to modulate in vivo in specific tissues or at specific times during growth the biosynthesis of cell wall polymers. At the same time, it is becoming more and more obvious that the establishment of the plant wall requires complex regulatory mechanisms which ensure the transport of Golgi vesicles containing polysaccharides towards particular areas of the wall. Several actors in these processes are beginning to emerge. We can cite, for example, variations in intracellular calcium, the dynamics of actin filaments or the interactions between membrane proteins involved in polarized growth. Until today, no study has clearly demonstrated the interactions that exist between these actors and the biosynthesis, then the establishment of the wall. Better understanding these mechanisms and even, ultimately, modulating them would allow, in addition to enriching our fundamental knowledge, significant agronomic advances. Modulating the quality of reserves or plant fibers through treatment and avoiding varietal selection would represent a major advance in agronomy. | Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking | 6project_grants_public |
gen_a9f6d5833ea6f901805a12d9ac4b0e06 | FEDER - UNICAEN - Design, synthesis and biological evaluation of MT5-MMP inhibitors - FONCT | Kohesio | UNIVERSITE DE CAEN NORMANDIE | https://linkedopendata.eu/entity/Q3673505 | Alzheimer's disease, the most common form of senile dementia, affected thirty-five million people worldwide in 2010 and this figure could rise to sixty-five in 2030 with a medical and societal cost estimated at that date at more than $1,100 billion. The only drugs available today, acetylcholinesterase inhibitors, have a purely symptomatic action and their effectiveness also decreases with the progression of the disease. To stop this, numerous studies have been carried out, this time no longer targeting the consequences but the molecular causes of neuronal death. These are becoming better and better known today. They appear numerous and intricate. The main one remains the aggregation of the amyloid peptide causing so-called senile plaques and significant neurotoxicity leading to the cognitive disorders accompanying the disease. This is why a lot of work aimed at preventing amyloid aggregation has been carried out around the world. One of the means undertaken to achieve this was to prevent the formation of the amyloid peptide by inhibiting the cleavage enzymes of its precursor, the APP protein. Numerous beta and gamma secretase inhibitors have been designed and shown to be effective in vitro. Unfortunately, the clinical trials undertaken so far had to be stopped due to the toxicity manifested by these inhibitors linked to the involvement of beta and gamma secretases in numerous other physiological processes. A new enzyme involved in the cleavage of the APP protein has, however, just been discovered. This is the matrix-metallo proteinase MT5, also called n-secretase, at the origin of the formation of another synaptotoxic peptide, the amyloid n alpha peptide, also involved in the neuroinflammation which accompanies Alzheimer's disease. No selective inhibitor of this enzyme has so far been described and the discovery of such an agent sparing beta and gamma secretases would make it possible to verify the potential therapeutic interest residing in this new biological target. This is what the MT5-MMP program intends to carry out, conducted at CERMN in partnership with the Neurobiology of Cellular Interactions and Neurophysiopathology (NICN) unit in Marseille, which has demonstrated the role played by this enzyme in the pathogenesis of Alzheimer's disease and has in vitro models making it possible to evaluate potential inhibitors. This project is partly financed by the revitalization agreement signed between the State and the laboratory Merck Sharp and Dohme and which awarded CERMN a donation of 80,000 euros without any compensation. CERMN was chosen as the only research unit to benefit from this agreement due to its recent work leading to the identification of a promising drug candidate in the treatment of Alzheimer's disease. This project is therefore part of the intelligent specialization area of RIS3 Innovations in Biomedical Sciences and Technologies. | Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking | 6project_grants_public |
gen_5b4da64bad51ecd4a55b6ed0fcddcb41 | FEDER - INSERM - Support for research projects - Project "Immunotherapy targeting the tPA/NMDA receptor interaction for the treatment of pathologies of the central nervous system" (Invest) | Kohesio | EPA INSERM INSTITUT NAT DE LA SANTE ET DE LA RECHERCHE MEDICALE | https://linkedopendata.eu/entity/Q3673447 | Not available | Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking | 6project_grants_public |
gen_cf31c3352c82eab293c4c5c0f561d934 | FEDER - URN - CELLECT - EMERGENT | Kohesio | UNIVERSITE DE ROUEN-NORMANDIE | https://linkedopendata.eu/entity/Q3681623 | Antibiotic resistance is a process that has accelerated worryingly in recent years due to the misuse of antibiotics in human and animal health and the reduction in investment in the research and development of new molecules. The exhaustion of therapeutic options has favored the emergence of resistant or even multi-resistant strains, caused an extension of the duration of hospitalizations and increased the mortality rate linked to bacterial infections. To try to control this phenomenon and coordinate efforts at the international level, the World Health Organization has published a list of priority germs to promote research which aims in particular to identify new molecular targets in several pathogens leading to fatal infections including Pseudomonas aeruginosa. P.aeruginosa is a well-known opportunistic human pathogen responsible for acute and chronic infections whose pathogenesis is largely linked to its ability to adapt to the environment. Remarkably sophisticated in P. aeruginosa, the envelope is a very dynamic compartment whose very finely regulated lipid and protein composition adjusts to the conditions encountered in the external environment to allow the bacteria to adapt its physiology and the permeability of the membranes, and thus counteract the effect of numerous attacks, including in particular those linked to the action of antibiotics or the immune system. For these reasons, the identification of new structural elements significantly involved in its homeostasis and/or its integrity is an avenue of choice to consider potentiating the activity, or developing in the longer term, new anti-Pseudomonas molecules. In this context, the functional characterization of mechanosensitive ion channels and their involvement in the remodeling of the bacterial envelope constitutes a relevant and still unexplored research theme in P. aeruginosa. MechanoSensitive Channels (MSCs) are ubiquitous membrane proteins forming aqueous channels whose mechanical opening allows rapid flows of intra- or extracellular molecules according to their chemical gradient. By converting a physical force into an electrochemical signal, these proteins constitute or are part of mechanosensing systems well known in higher organisms to regulate essential physiological processes, such as hearing, touch, blood pressure in humans or morphogenesis and root orientation in plants. Relatively well studied from a structural and biochemical point of view in the model organism Escherichia coli for their involvement in the response to hypo-osmolarity, their involvement in bacterial physiology and envelope homeostasis, remains highly investigated, although their role in bacterial pathogenicity or the response to antimicrobials is only emerging in recent years through a few cross-sectional or global studies without being the subject of specific in-depth study in bacteria pathogens. Interestingly, P. aeruginosa has 8 putative MSCs (6 in E. coli) of different sizes which generally contain one or more additional protein domains, suggesting their specific involvement in physiological processes.(...)See the rest in the attached document. | Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking | 6project_grants_public |
gen_636b50a10964793a8d66ae4d059e7700 | FED INV - 15E00432 - CAEN UNIVERSITY - JKUB | Kohesio | UNIVERSITE DE CAEN NORMANDIE | https://linkedopendata.eu/entity/Q3673305 | In the digital age, all training and teaching structures must face new issues while meeting learner training requirements. The evolution of digital tools, the massification of teaching, the change in attitudes and mentalities are all challenges to be met. Teachers must adapt to a new audience (Digital Natives) whose relationship to knowledge and learning has evolved. This evolution involves the implementation of new forms of learning such as active learning, collaborative learning and also playful learning. Currently, students invest a phenomenal amount of time gaming on the Internet and through mobile applications. “The gaming generation has developed a new cognitive style characterized by multitasking learning, relatively short attention spans during learning, and a way of learning that relies on exploration and discovery. Today's adolescents have strong visual and spatial skills, undoubtedly supported by their playing video games. They prefer to learn by experimenting rather than being taught. Elise Lelièvre, teacher in the Biological Engineering department of the IUT of Caen, has been experimenting with these innovative teaching practices for several years by integrating games into her teaching. She developed a board game, such as a goose game, to encourage the learning of her students as part of her Systematics course. Principle of the game: the player throws a die and advances the corresponding number of squares. Several challenges are proposed: charades, riddles (MCQ), question on a photo, "proxi (search for the 2 animals having the most recent common ancestor among those proposed), History (question on the historical aspect of classifications). Beyond the interest of the game to capture their attention, it actively involves the students in the development of new challenges of the game, which contributes to the appropriation of knowledge by the learners. At the teacher's level, factors such as insufficient face-to-face time and too many students do not allow her to implement this type of activity in all her courses. One response to this problem: decline this educational game in virtual mode (online), a mode which perfectly meets the Digital Native generation. At the scale of an establishment, the virtual modality would allow teachers and trainers to offer this educational activity during individual or group online learning times, to respond to the problem of training flexibility and the need to develop training systems in mixed modality. Thus, for the reasons mentioned above, but also to facilitate the adhesion of teaching teams to this new form of learning and support them in the development of educational games, UNICAEN wishes to develop a generator of virtual board games: JKub (J for I Play and I Learn). A benchmark made it possible to confirm the popularity and impact of games in learning. Many applications, such as online exercisers, allow the creation, configuration and distribution of interactive assessment activities but without the board game dimension. In this category, we identified the LearningsApps application as the most interesting. Regarding the design of virtual board games, the only existing design and sharing application is the design environment of the Carrefour Virtuel de Jeux Éducatifs developed by the SAVIE team (Quebec) but this project was developed in 2001. The games are generated in Flash format. This technology is obsolete. Our virtual board game generator will be developed in HTML5 to be readable on all media, including mobile media (tablets and smartphones). | Smarter Europe / Information and communication technology / e-Government services and applications (including e-Procurement, ICT measures supporting the reform of public administration, cyber-security, trust and privacy measures, e-Justice and e-Democracy) | 6project_grants_public |
gen_c7c17d4a88d3d49ba5dacbf57131e6d7 | FEDER - URN - FARM - INVEST/FONCT | Kohesio | UNIVERSITE DE ROUEN-NORMANDIE | https://linkedopendata.eu/entity/Q3680678 | The problems associated with the microstructures of semi-crystalline thermoplastic polymers appear today as major challenges, in terms of fundamental knowledge but also for application questions. It has been shown, in particular by partner 1, that semi-crystalline polymers must be described not by a simple two-phase model, but by a three-phase model where the 3rd phase (the rigid amorphous fraction, RAF) is a nano-phase located between crystalline phase and mobile amorphous phase. Taking RAF into account is essential to understand the physical and chemical properties of many materials very common in regional industry, both in the packaging sector (Sidel, Aptar) and in the aeronautics sector (Zodiac, Safran). Indeed, the presence of a rigid amorphous nano-phase is to be expected not only in the case of semi-crystalline polymers, where the amorphous chains are "blocked by the development of more or less regular crystalline domains, but also in the case of composite materials with a polymer matrix, a specialty of partner 2, where the action of is exerted by the reinforcements at the interface with the matrix. If thermosetting polymers have been almost exclusively used for decades in the field aeronautics, recent advances in terms of synthesis and implementation have allowed the emergence of thermostable semi-crystalline polymers with very promising thermomechanical properties. However, technological obstacles persist and a better understanding of the complex microstructure of these materials seems necessary. For example, the analysis of these materials in terms of a three-phase model has never been done. However, the microstructural understanding of composite materials with a thermoplastic polymer matrix requires the description of the matrix/fiber interfacial zone, but also the characterization of the local domains of stiffening of the amorphous phase very close to the interface (if the matrix remains amorphous) or close to the crystalline domains (if the matrix can crystallize), subjects not currently addressed on such complex materials. Also, having academic expertise in this field could make it possible to develop, in the medium term future, collaborations with the industrialists concerned. The detailed study of such complex materials (multiphase composites) is a real challenge, it is therefore necessary to model and try to understand the microstructure-mechanical properties links by analyzing model materials. One of the big pitfalls of such work by physicists is not investigating the chemical aspect. Indeed, polymers are complex materials in every respect (distribution of molecular masses, degradation by different mechanisms, presence of impurities and adjuvants, sensitivity to aging) and not being interested in this aspect limits the relevance of this work. Partner 3, through its skills in polymer chemistry, will significantly strengthen this project and for the first time, Norman researchers in mechanics, chemistry and physics of polymers are offering a multidisciplinary approach to characterize polymers and their composites. The mechanical behavior of these materials is closely linked to the solid state structuring of the macromolecules that constitute them: crystallinity, RAF, etc. The temperature and shear conditions required for shaping composite materials degrade chemically these macromolecules and are therefore likely to induce modifications in their structuring and their final properties. This project therefore aims to establish links between nanoscale structuring and the macroscopic behavior of semi-crystalline polymers used to produce composites for the aeronautics sector. | Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking | 6project_grants_public |
gen_d86e4700295cf9149c66fcc4bbdfa009 | HN0001404 - EDUCATION AND TRAINING - ADAPTATION AND EVOLUTION OF THE DALIA DEVICE FOR TABLETS AND SMARTPHONES | Kohesio | EDUCATION ET FORMATION | https://linkedopendata.eu/entity/Q3680760 | A study currently being published at UNESCO concludes that the development of reading on telephones and mobile devices is a means of combating illiteracy effectively and at a lower cost in developing countries. At the same time, a study by Credoc (2011) highlights the fact that 42% of unconnected French people cite the complexity of the tool as their "main obstacle". Today, the development of nomadic devices (or connected mobility) introduces many uses. more adapted and intuitive. The “simplicity” and accessibility of touchscreen, the equipment rate. Smartphones, even among audiences who have difficulty with writing, are effective means for digital inclusion that we regularly observe among our audiences. The apprehension of the tool, the supposed technicality of using it, is therefore much less present with portable devices, which pushes us to consider a “touch” version of DALIA. During certain support or training workshops, we already offer beneficiaries the opportunity to use their mobile phones to browse the internet and use applications that are necessary for them in their daily lives, job searches to be as independent as possible, without necessarily having a computer available. Furthermore, DALIA's current programming language, Action Script 3, linked to Flash technology which allows the development of "animated" and interactive content, is in complete decline. Its publisher Adobe, having also announced its abandonment in the years to come. In its current design, DALIA is already designed with a simple and guiding learning environment, tactile transposition will therefore be facilitated. the possibility of enriching the catalog, thus creating an "Educational content production community" of the collaborative and participatory web, by sharing: the use of achievements operating costs We wish to "open" and enrich the DALIA catalog to benefit audiences in difficulty with basic skills, who do not have access to training. To meet this ambition, we offer a shared online scripting tool an expanded partnership approach I Screenwriting tool (Back office): This tool is already available in the current DALLA version (below) and has made it possible to create scenarios with other structures, other networks, even if these pooling initiatives have remained, from our point of view, insufficient. In 2011, we co-developed an activity with the Chantier Ecole network on a situation of production of an integration site allowing us to work on the key skills mobilized: | Smarter Europe / Information and communication technology / e-Government services and applications (including e-Procurement, ICT measures supporting the reform of public administration, cyber-security, trust and privacy measures, e-Justice and e-Democracy) | 6project_grants_public |
gen_099a6238b7e5998ac99bcc2f6f13f0b5 | FEDER HN0002385 - UNIVERSITY OF HAVRE NORMANDY - MADNESS - FONCT/INVEST | Kohesio | UNIVERSITE LE HAVRE NORMANDIE | https://linkedopendata.eu/entity/Q3680621 | The MADNESS project concerns the FEDER/FSE-IEJ 2014-2020 operational program in the Haute-Normandie Region: Axis: Promoting the competitiveness of Haute-Normandie by promoting research, innovation and the digital economy Pierre Levy in his book collective intelligence: for an anthropology of cyberspace published in 1994 announces a change in modes of communication and access to know. It describes a cyberspace, a place of work, communication and thought for human organizations. It offers us an anthropological perspective with collective intelligence as its driving force. After basing our relationships and interactions on spatialization, cyberspace frees us from this constraint and virtualizes distances. Communicating objects which may be autonomous and mobile, diffuse, ubiquitous and pervasive computing participate in this and allow us to envisage smart cities or even more broadly an "intelligent territory" integrating the city, the natural environment but also the production sector. Networks, whether real or virtual, underlie these objects connecting information and instrumentation systems, sensor and information networks and storage spaces. The GRR LMN's than a more detailed analysis of their functioning and their dysfunctions. In particular, by evaluating and reducing operating risks, these masses of data are useful for improving the security of systems, of the operators who control them as well as of the populations around them. It is still necessary to be able to model and then analyze this information efficiently and quickly. in the context of big data, these treatments have become a real scientific lock and constitute the main challenge of the project structuring the GRR TERA-MRT that we propose "Modeling and analysis of Data for the Security of Complex Systems (MADNESS)" The project is the result of close collaboration between different laboratories in Upper Normandy: -GREAH, University of Le Havre - IRSEEM, ESIGELEC, University of Rouen -LITIS, University of Le Havre, University of Rouen, INSA of Rouen -LMAH University of Le Havre -LOFIMS, INSA of Rouen - LSPC, INSA of Rouen, University of Rouen -IDEESUniversity of Rouen, University of Le Havre, University of Caen - CETAPS, University of Rouen - CORIA, University of Rouen - LOMC, University of Le Havre | Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking | 6project_grants_public |
gen_9ae87970dd24c9469fb6c469d402b09e | FEDER - UNICAEN - HAIS | Kohesio | UNIVERSITE DE CAEN NORMANDIE | https://linkedopendata.eu/entity/Q3680434 | The HAIS (Human Adaptibility In-Situ) Project consists of measuring the physiological adaptation capacities of humans while immersed in different extreme environments for general public, sporting, scientific, biotechnological and medical applications and benefits. This project proposes two in-situ protocols in which physiological and chronobiological parameters will be studied in two different conditions, the first to assess the impact of climate and ultra-endurance and the second to assess the impact of ultra-endurance on human performance:1. The 4x30 Day Adaptation Project2. the Ultra Trail Sciences Project Clécy – Suisse Normande (UTSPC). Changes and Adaptations are the key words of the current century. Whether we like it or not, whether we accept it or not, our worlds are evolving; our lives undergo changes; our environments are transforming. Humans must change their way of living to ensure a future on our planet, by reducing their pollution, of course, but also by adapting more than ever to their environment, forcing them to surpass themselves. But are we capable of it? What are our resources? How can we develop new skills to react better and faster? To build tomorrow, we must understand today's humans in their environment. The HAIS Project is an original project, never before carried out and aims to study the physiological adaptation capacities of Humans in extreme real situations, a formidable accelerator of Adaptation capacities. This file presents two innovative, original and unique scientific projects in the world. He initiates collaborations between the main teams (UMR INSERM University of Caen COMETE U1075 and the Cognitive and Computational Neuroscience Laboratory (LNC2) at the Ecole Normale Supérieure in Paris (UMRS INSERM-ENS U960) for the Adaptation 4x30 Jours project which received ANR DGA ASTRID 2019 funding, and stimulates collaboration between members of the COMETE U1075 team and other national and international research teams for the UTSPC project While the Adaptation project led by the famous explorer Christian CLOT, vice-president of the Société Française des Explorateurs, a recognized public utility organization, will go on an expedition with 20 people to the 4 most extreme environments on the planet from September 2020, the UTSPC project will consist of organizing the world's first ultra-endurance race. 160 km dedicated to scientific research in Clécy in Suisse-Normande. These unique projects will promote the University of Caen and the Normandy Region through all the scientific publications and the organization of an international congress on Ultra Endurance Practices (Trail, Sailing), through the extremely significant media coverage of these expeditions, through the strong socio-economic benefits particularly in Suisse-Normande where Clécy will become an open-air laboratory, through the publication of a scientific and educational work on the Ultra Trail and through the involvement of regional companies developing biomedical devices. Finally, this file will present all the funding requests which will allow the implementation of the studies but also the financing of doctoral students. | Smarter Europe / Research and innovation / Research and innovation infrastructure (public) | 6project_grants_public |
gen_e00185d1b0d11966c20bb47531e01415 | FEDER - ACTALIA - MOBIDIC PROJECT - ANR | Kohesio | ACTALIA | https://linkedopendata.eu/entity/Q3673628 | The protozoa Cryptosporidium spp, Giardia duodenalis and Toxoplasma gondii are recognized as priorities in terms of public health, in particular because of their possible transmission via water to humans. Currently, their detection in water is done by immunofluorescence (IF) after filtration of large volumes of water (20 to 100 L). However, this methodology suffers from numerous disadvantages: cost, time-consuming (filtration+IF), and dependent on experienced personnel. Furthermore, the results obtained by water filtration vary depending on the physicochemical and meteorological parameters, which are particularly important in the current context of climate change. This project proposes to use the bioaccumulation capacity of these protozoa by bivalve molluscs to assess the level of water contamination. Molluscs have the advantage of being representative of the environment in which they live, of having an integrating nature of contamination thus limiting the variability of measurements in time and space. In order to be able to implement water monitoring on a large geographic scale and allow comparison between different water sources (fresh and marine), two species of mussels will be considered: the blue mussel (Mytilus edulis) and the zebra mussel (Dreissena polymorpha). This innovative approach requires removing a certain number of obstacles: 1) having a sensitive procedure for the simultaneous extraction of the 3 protozoa, their detection and their quantification in the molluscs; 2) correlate water contamination levels with the load measured in mollusc tissues; 3) characterize the environmental and physiological parameters that modify the accumulation capacity of protozoa. Importance of co-financing with regard to the ACTALIA strategy: To date, ACTALIA Food Safety is recognized at the national level as a reference center in food virology. This positioning, supported by the Region for several years, was possible via the UMT ACTIA VIROCONTROL with the University of Nancy and through co-financed public research projects. ACTALIA is now the preferred partner of the Administration and manufacturers on this now proven biological danger. Protozoan parasites represent emerging dangers in raw plants and shellfish and water. It is therefore necessary to develop expertise which will be made available to professionals and competent authorities in the coming years, and ACTALIA aims to become the reference technical center for these dangers in food. This ANR project is part of the UMT ACTIA PROTORISK, in partnership with the University of Reims (2015-2019), which will contribute to the positioning of ACTALIA at the national level. Public research projects with reference laboratories and companies make it possible to develop this expertise and co-financing is necessary to carry out these 50% funded projects and consolidate ACTALIA's strategic positioning in food safety. Interest of this project for the region: The project is part of a current context of deterioration of water quality in Normandy. The new tool proposed to measure water quality in an integrative manner should make it possible to respond to the region's challenges aimed at maintaining the quality of its water intended for aquaculture and recreational activities. This approach could be extended to other pathogens of fecal origin (bacteria, viruses) in order to implement robust and comprehensive surveillance plans in areas considered to be at risk, in fresh water and sea water. In the long term, this project constitutes added value for Normandy, which will be reinforced in the territory, by the knowledge and expertise acquired by ACTALIA as part of this program. | Smarter Europe / Research and innovation / Technology transfer and university-enterprise cooperation primarily benefiting SMEs | 6project_grants_public |
gen_11830ace7441989b3aff8d85e5471da1 | FEDER - ULHN - SUPERMEN - INVEST/FUNCT | Kohesio | UNIVERSITE LE HAVRE NORMANDIE | https://linkedopendata.eu/entity/Q3680606 | The objective of the SUPERMEN project is to increase the skills of three Norman partners working on the aging and characterization of metallic materials, on the surface and in volume, and from the macroscopic scale to the atomic scale. It draws on the strong existing skills of the various partners and their experimental platforms, which must be supplemented by the acquisition of new equipment and the development of suitable protocols. The lifespan of metallic materials is limited by microstructural developments during use, which in certain cases can lead to the ruin or breakage of certain parts. Understanding aging mechanisms is therefore essential if we want to anticipate their consequences, from an economic and security point of view. This aging results from an attack from the external environment, which generally begins on the surface of the material before extending to its volume. This is a significant industrial problem because it causes accidents due to broken parts, and which induces significant costs. The modifications resulting from this aging must therefore be able to be identified and quantified if we want to be able to predict the evolution of the state of a metal part, or even its failure. It is in this context that the SUPERMEN research program takes place, which aims to broaden the area of expertise and the skills of three partners (GPM from the University of Rouen, CRT A&S from Val-de-Reuil and LOMC from the University of Le Havre) which are complementary in this field.When it comes to studying the oxidation or corrosion of metallic materials, the characterization of their surfaces is the essential first step. The notion of surface refers to a layer of several hundred microns (affected by the diffusion of oxygen for oxidation, nitrogen for nitriding, etc.), or a few atomic layers when we are talking about the protective layer of chromium oxide on stainless steels. These different scales, from a fraction of a millimeter to a few nanometers, must be covered by the joint CEVIMAT laboratory which brings together the skills of the CRT Analysis & Surface (CRT A&S) and the Materials Physics Group (GPM). The aging of materials in volume generally results in an evolution of their microstructure and their mechanical properties. The GPM today brings together an experimental park (scanning and transmission electron microscopies, tomographic atomic probes, etc.) and skills allowing the best quantification of the parameters linked to the microstructure (nature, size, numerical density, dispersion, etc. of obstacles, chemical composition of the solid solution). It is important to be able to supplement these studies with analyzes using non-destructive methods, which can be applied to materials in service, while the degradation mechanisms are at work. It is then possible to monitor the long-term evolution of the properties of the materials, to estimate the aging of the material that the latter undergoes in use, for example during exposure to particular thermal/chemical factors, whether this aging is of internal origin (degradation) or superficial (corrosion). The Uncles et Milieux Complexes (LOMC) laboratory at the University of Le Havre intends to develop, as part of this project, Non-Destructive Testing (NDT) using EMAT technology in order to contribute to the identification and quantification of the aging of metals. This technology will allow the development, over the duration of the project, of a new measuring bench which will be added to those already existing, thus ultimately strengthening the possibilities of expertise already grouped within the LOMC experimental park in Le Havre in the field. of CND, and those concerning the aging and characterization of metal materials | Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking | 6project_grants_public |
gen_3dd61aeeac2751ccbf2b83e09fc826d7 | HN0005744 - CEVAA- CECOVIM2 | Kohesio | CTRE ESSAIS VIBRO ACOUSTIQUE AUTOMOBILE | https://linkedopendata.eu/entity/Q3680726 | This project is a continuation of CECOVOM phase 1 and aims to make investments in innovative technological means making it possible to implement and validate methodologies which were developed in the previous phase. Indeed, phase 1 consisted of defining methodologies, carrying out preliminary measurements and characterizations making it possible to make relevant the specifications of the technological means to be implemented to validate them (see phase 1 progress report and conclusion justifying this phase) | Smarter Europe / Research and innovation / Research and innovation infrastructure, processes, technology transfer and cooperation in enterprises focusing on the low carbon economy and on resilience to climate change | 6project_grants_public |
gen_2dbe82b3f1dc03fbeb7f7e863d33ae22 | FEDER - ANSES - AVEq-ACTIVE - TREMPLIN | Kohesio | AEP AGENCE NATIONALE SECURITE SANITAIRE ALIMENTATION TRAVAIL | https://linkedopendata.eu/entity/Q3680418 | The general objective of this study is to characterize and determine the mechanisms of action of molecules which have shown an antiviral effect against two equine respiratory viruses (AVE and HVE-1), following a screening of 2,900 molecules, in order to develop effective strategies for combating and controlling these diseases responsible for major economic losses for the equine industry. In this context, we have five objectives: Objective 1: Characterize the invitro pharmacological properties of molecules for which “hits” were obtained following high-throughput screening of 2,900 molecules from different public chemical libraries. Objective 2: Evaluate the effect of these molecules on gene expression of infected and non-infected equine cells. Objective 3: Evaluate the effect of these molecules on the activity of cellular kinases in our equine cell model. Objective 4: Evaluate the metabolic stability of molecules active against AVE and HVE-1 in an in vitro equine biological model (horse liver microsomes). Objective 5: Study the pharmacokinetics and toxicity of these molecules in horses. The originality of our project is based on the search for molecules with antiviral properties against two equine respiratory viruses. Indeed, to date no molecule has marketing authorization (AMM) to fight against viral infections in equines according to the National Veterinary Medicines Agency (ANMV). This project will therefore make it possible to expand the range of treatments available to combat equine viruses and the consequences of these infections on the equine industry. To do this, the project will be structured around four “work packages” WP1: Characterize the antiviral power of molecules/compounds from different chemical libraries WP2: Evaluate the effect of molecules on cells WP3: Pharmacokinetic and toxicological studies. WP0: Coordination and communication of project results. | Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking | 6project_grants_public |
gen_1465cb0aa78d539f2636f0bb17291b28 | Sustainable bio-waste resources for construction | Kohesio | Nomadéis Le Havre | https://linkedopendata.eu/entity/Q4296821 | Not available | Not available / Not available | 6project_grants_public |
gen_256e2b1da6150a674518796fed121721 | Assistive devices to empower distressed people using robotics | Kohesio | INSTITUT DE RECHERCHE EN SYSTEMES ELECTRONIQUES EMBARQUES | https://linkedopendata.eu/entity/Q4295345 | Not available | Not available / Not available | 6project_grants_public |
gen_e2654e0a7aa3687efed1011d17517cfa | Automatic Cross-Layer Synthesis of High Performance, (Ultra-)Low Power Hardware Implementations | French National Research Agency (ANR) | Institut National des Sciences Appliquées de Lyon - Laboratoire dIngénierie des Matériaux Polymères;Friedrich-Alexander-Universität Erlangen-Nürnberg, Chair for Hardware/Software Co-Design | Not available | Unknown | 6project_grants_public | |
gen_6ee6d07d83b8d4c429afe17c230765a4 | Chair to Prevent and Treat Pressure Injuries in Persons Living with Alzheimer's Disease and Related Dementias | National Institutes of Health (NIH) | MINNESOTA HEALTHSOLUTIONS CORPORATION | Not available | Unknown | 6project_grants_public | |
gen_3685f984d90e6061adb3fd83c46679f7 | Mapping and Improving Vocational Education in Costa Rica (MIVE-CR) | Swiss National Science Foundation (SNSF) | Chair of Education Systems D-MTEC Swiss Federal Institute for Technology ETH | Not available | Unknown | 6project_grants_public | |
gen_786cbfc303f8f6e52efa90ab18ad01a9 | The Swiss hospital capacity planning: An empirical evaluation of its impact on hospital service delivery, quality and costs | Swiss National Science Foundation (SNSF) | School of Medicine, Chair of Health Care Management;Lehrstuhl für Management im Gesundheitswesen School of Medicine Universität St. Gallen | Not available | Unknown | 6project_grants_public | |
gen_abfe5b238ca5291cf0c762c4bc32c44e | Hugur: Developing an application to support the mental health of university students through a digital intervention | Swiss National Science Foundation (SNSF) | Chair for Digital Health Interventions School of Medicine Universität St. Gallen | Not available | Unknown | 6project_grants_public | |
gen_83f9674e44622eb93539c161cd78ab6e | Phosphorus REcovery for FertiLisers frOm dairy processing Waste | European Commission | TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY; ARRABAWN CO-OPERATIVE SOCIETY LIMITED; JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION; CHALMERS TEKNISKA HOEGSKOLA AB; Wageningen University and Research Centre | CORDIS-814258 | REFLOW is an interdisciplinary cross-sectoral European Training Network combining world-leading scientists and key stake-holders in dairy processing, fertilizer production and phosphorous recycling with early stage researchers to address important technical and socio-economic challenges associated with the recovery of phosphorous from dairy processing waste water and its recycling into fertilizer products enabling sustainable expansion of the dairy industry in Europe. REFLOW research will (i) mitigate the environmental impact of dairy processing waste on soil and water, (ii) provide safe environmentally sustainable, cost effective closed loop solutions for crop nutrient management (iii) meet the demand for skilled professionals to support the technical, regulatory and commercial development of the market for recycled phosphorous fertilizer products in accordance with the deliverables of the Circular Economy Package. REFLOW will achieve these goals by creating an innovative and entrepreneurial training environment for the next generation of scientists. 13 ESRs will be recruited in a network of 10 beneficiaries and 14 partner organisations who bring complementary expertise and experience of delivering technical solutions, socio-economic modeling, environmental analysis, policy frameworks, high level training and commercial entrepreneurship. Graduating fellows will be equipped with a unique range of relevant interdisciplinary and cross-sectoral skills for careers as independent industrial or academic researchers, entrepreneurs, regulators or agri-environmental specialists. REFLOW will train the Fellows through an integrated and cohesive curriculum of network-wide partner training activities including industrial secondments and embedded commercially driven research projects. The outputs from REFLOW will influence land management practice, the rural bio-economy framework and EU policy goals while significantly progressing the state-of-the-art in Phosphorous recycling. | H2020-EU.1.3. / 1.3 Marie Skłodowska-Curie Actions (MSCA) | 6project_grants_public |
gen_92f89592455bcb3dba79335be58ef0dd | FEDER - ANSES - ALGOEVA PROJECT | Kohesio | AGENCE NATIONALE DE SECURITE SANITAIRE ALIMENTATION ENVIRONNEMENT ET DU TRAVAIL | https://linkedopendata.eu/entity/Q3680080 | Over the past fifteen years, it has been established that anthropogenic activities combined with natural climatic factors lead to an acceleration of changes in agricultural crop conditions. As a result of these disturbances, plants undergo higher intensity abiotic stress. However, abiotic stresses (extreme temperatures, high salinity, drought, flooding, excess heavy metals, oxidative stress) are the leading cause of loss of agricultural production yields worldwide. In a global context where the challenge of tomorrow is to produce enough to feed an exponential world population, it is a question of innovating in techniques and products intended for agriculture while regulating and legislating effectively to ensure healthy and sustainable development of agricultural production throughout the world. The use of biostimulants is one of the innovative methods allowing sustainable production by limiting the supply of inputs (fertilizers, phytosanitary products). By definition, biostimulants are organic compounds that improve the growth and development of plants. Companies developing in this field need to have precise and rapid tools (bioassays) to test new molecules or extracts and understand their mechanisms of action to guarantee their effectiveness for producers while meeting the requirements of legislators. At the European level, a special council made up of biostimulant producers (EBIC) was created in 2011 to respond to this demand at the legislative and commercial level. Several companies producing algae extracts, including ALGAIA, collaborate within the EBIC on analytical and formulation aspects. Indeed, algae have been used for several generations to improve the performance and quality of plants. Among the molecules isolated from distinct algae sources, some (polysaccharides, mannitol, hormones, antioxidant compounds, etc.) have biostimulating properties. Algae also represent a source of molecules (dextran sulfate, heparin, sulfoevernan, fucoidans, etc.) with antiviral and antibacterial activities. Viral and bacterial infections constitute a major health risk for equines and cause significant economic losses for the equine industry. Thus, the Equine Viral Arteritis (AVE) virus persists in 30 to 70% of infected stallions in the accessory glands of the reproductive system. The virus is excreted in semen. These excretory standards constitute the reservoir of the virus, but no specific treatment allowing the elimination of the virus is currently available. Lik... | Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking | 6project_grants_public |
gen_279608993f3bfb48bedecc69bbd6afb0 | Livestreaming af Offentlige Foredrag | Carlsberg Foundation | Aarhus University | CF23-0010 | In the project 'Offentlige foredrag i Naturvidenskab' scientists lecture citizens on changing subjects about natural sciences. These two-hour evening lectures are getting live streamed to cinemas, community centres, schools, libraries, Danish University Extension, clubs etc. in Denmark, Greenland, the Faroe Islands and Germany.What? Why? How? | Research / Conferences / Award | 6project_grants_public |
gen_c007e89e58529caf1cb20fd56fc3cca2 | FEDER - URN - SPIDER - INVEST/FONCT | Kohesio | UNIVERSITE DE ROUEN-NORMANDIE | https://linkedopendata.eu/entity/Q3680695 | Improving the energy efficiency of energy production or propulsion systems requires a better understanding of the multiple processes involved, a key point for relevant innovations. This objective, which is based on the ability to characterize the progress of reactions and the production of pollutants in situ, is based on the availability of efficient laser diagnostics. This project aims to create an international level center of expertise in the development and exploitation of ultra-fast laser sources in the energy field. It draws on the unique expertise of three Norman laboratories: the Research Center on Ions, Materials and Photonics (CIMAP), the Interdisciplinary Research Complex in Aerothermochemistry (CORIA) and the Catalysis and Spectrochemistry Laboratory (LCS), which have expertise ranging from the development of new materials and the development of ultrafast lasers to the implementation of innovative optical diagnostics in combustion systems and the study of depollution processes by catalysis. The CORIA laboratory is the holder of the PERCEVAL industrial chair (ANR/SAFRAN Tech) which aims to develop and analyze the aeronautical technologies of tomorrow and the use of ultra-rapid laser diagnostics for the study of high-pressure combustion. Ultrafast sources operating at high rates beyond kHz while retaining significant energies open up perspectives for the temporal monitoring of the evolution of physical quantities measured in complex environments, which represents a major advance compared to the same diagnostics operating in the nanosecond regime at a rate of around ten Hz. Another very promising application of these high rate sources concerns the dynamic study of reaction mechanisms in depollution processes by catalysis. Current developments in these areas are based on commercial laser systems which are based on massive crystals mainly of titanium-doped sapphire. However, these systems are limited in throughput due to thermal problems in the crystals. Emerging technologies, based on optical fibers or advanced crystalline architectures pumped by diodes, are paving the way for the production of ultrashort, high-energy light pulses at rates of several tens of KHz. In this context, the CORIA laser team has acquired extensive experience in the development of ultra-fast laser sources based on optical fibers, as evidenced by its numerous innovations in the field (three patents, one of which is the subject of an industrial exploitation license). In addit... | Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking | 6project_grants_public |
gen_823f49db8eed320331cf7f7f8d614736 | Conservation training in Africa | Arcadia Fundation | Tropical Biology Association | 360G-ArcadiaFund-3616 | To train African biodiversity conservation professionals. | Leadership / Strategic | 6project_grants_public |
gen_a3a323bcbed0c2efd2594fc58dd65cdb | Millennium Seed Bank Partnership – Threatened Biodiversity Hotspots Programme | Arcadia Fundation | Royal Botanic Gardens Kew | 360G-ArcadiaFund-4194 | To collect seeds and build in-country conservation capacity in biodiverse hotspots experiencing rapid and drastic land use changes. | On-site conservation / Strategic | 6project_grants_public |
gen_c976bd532b40677cfbd80eaae42d76a4 | Field book project - South America | Arcadia Fundation | Smithsonian, National Museum of Natural History | 360G-ArcadiaFund-3627 | To digitize and make publicly accessible travellers' and naturalists' field manuscripts on South America, 1800 to 2000. | Leadership / Strategic | 6project_grants_public |
gen_17fb7b8ca65e84c819b9d70d5edcca3d | Religion and Democracy in Europe | Arcadia Fundation | Network of European Foundations | 360G-ArcadiaFund-2505 | To research how Europe can peacefully accommodate changing attitudes to religion without compromising secular democratic freedoms, | Discretionary / Discretionary | 6project_grants_public |
gen_605f58d8da7ab45262f35065ddcb731a | An oral history of farming, land management and conservation in post-war Britain | Arcadia Fundation | National Life Stories | 360G-ArcadiaFund-4101 | To record interviews with farmers, land owners, scientists and representatives from organizations about the experience of change in farming practices, landownership and land management in Britain after World War II. | Discretionary / Discretionary | 6project_grants_public |
gen_2bff109f5340095d442d75371ee6b88c | History of Jewish Mysticism and Esotericism (Toledot Torat Hasod Ha'ivrit) | Arcadia Fundation | Zalman Shazar Center for Jewish History | 360G-ArcadiaFund-2712 | To support the research and publication of Professor Joseph Dan’s multi-volume history of Jewish mysticism. | Other / Strategic | 6project_grants_public |
gen_539810c55a9ba8ce5afdd1c69dad8fc3 | Community-led Open Publication Infrastructures for Monographs | Arcadia Fundation | Coventry University | 360G-ArcadiaFund-4192 | To provide match funding for the Community-led Open Publication Infrastructures for Monographs (COPIM) project, which will address the key technological, structural and organizational hurdles - around funing, production, dissemination, discovery, reuse and archiving - which are standing in the way of the wider adoption an impact of open access books. | Books / Strategic | 6project_grants_public |
gen_d23090ab89ba6bb5325d6773463248cc | Internationalization of Arches data management platform software | Arcadia Fundation | Getty Conservation Institute | 360G-ArcadiaFund-4561 | To develop a new software module for the Arches data management platform | Heritage sites / Strategic | 6project_grants_public |
gen_b20e3aa463dc482ab036315959c3f12f | Endangered Languages Documentation Programme | Arcadia Fundation | Berlin-Brandenburgische Akademie der Wissenschaften | 360G-ArcadiaFund-4492 | To support documentation of the most endangered languages around the world, and to archive and publish this material online in an open-access database. | Intangible culture / Grant programme | 6project_grants_public |
gen_d1b84e6efb081b2b22cd3eab375d4f47 | History of Jewish Mysticism and Esotericism | Arcadia Fundation | Zalman Shazar Center for Jewish History | 360G-ArcadiaFund-3620 | To support the research and publication of Professor Joseph Dan's multi-volume history of Jewish mysticism and esotericism. | Other / Strategic | 6project_grants_public |
gen_e37226b9f3b3a004eb74bce4592b2786 | Documentation of maritime archaeology in the Middle East and North Africa | Arcadia Fundation | University of Southampton | 360G-ArcadiaFund-4067 | To document endangered maritime archaeological heritage in the Middle East and North Africa and to publish the results through an online database. | Heritage sites / Strategic | 6project_grants_public |
gen_54d571e6b752b5abfb6c40dcb30ea1dd | Xarxa interhospitalària catalana de variants genètiques per millorar el diagnòstic genètic en malalties rares | La Marató de TV3 | Fundació per a la Recerca i la Docència Hospital Sant Joan de Déu - FSJD | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_463b3768745c1c2bd73be75250a1ee4b | Chronic Diseases and Urban Health incorporating the TB case-control platform | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_01348 | The Chronic Diseases and Urban Health platform will support the planned work on non‐communicable diseases and emerging health risks. It will evolve from the current TB Case Contact (TBCC) platform and include existing patients’ cohorts, e.g. rheumatic heart disease, who will be visited at least once a year to collect information on (among others) environment, socio‐economic status and risk factors related to lifestyle. This platform will work as a ‘targeted’ urban health surveillance system and possibly develop into an urban HDSS. The TB case-contact platform was established at MRC in 2001 and allows multi-disciplinary analysis of TB across the spectrum of infection and disease with over 2000 TB cases and 10000 close contacts enrolled to date. The platform has generated over 120 publications including epidemiological, clinical, microbiological, and immunological investigations and is currently recruiting participants for studies on post-TB lung health, a phase III TB vaccine trial, diagnostic and prognostic analysis of TB cases and their contacts and community screening of sub-clinical TB. The CD&UH platform will include the existing cohorts of TB, chronic liver disease and rheumatic heart disease patients and patients with other chronic diseases such as hypertension, diabetes, and chronic respiratory diseases, e.g. asthma. Patients and their families will be visited at least once a year and data on demographic variables, environment, socio‐economic status and risk factors related to lifestyle, health seeking behaviour, etc. will be collected. For each patient in the cohort, we will identify three neighbouring families for which we will collect the same information. | 2.4 Surveillance and distribution / Unit | 6project_grants_public |
gen_ad1491f224129efd8f6fcf3ca9ba70bb | Open access for terminated award 109164/Z/15/Z | Wellcome Trust | University College Dublin | HRCS22_11949 | No abstract available for this analysis | HRCS Research Uncodeable | 6project_grants_public |
gen_b74371b5290f6e21126c55ce0aa41c22 | Open access for terminated award 071613/Z/03/Z | Wellcome Trust | Telethon Kids Institute | HRCS22_12001 | No abstract available for this analysis | HRCS Research Uncodeable | 6project_grants_public |
gen_22385fc0313fb51823082fd2aadf54e1 | Open access for terminate award 219600/Z/19/Z | Wellcome Trust | University of Cape Town | HRCS22_12043 | No abstract available for this analysis | HRCS Research Uncodeable | 6project_grants_public |
gen_f4896654b1a46f7e3e85f456615ac940 | Open access for terminated award 107591/Z/15/Z | Wellcome Trust | University of Auckland | HRCS22_12105 | No abstract available for this analysis | HRCS Research Uncodeable | 6project_grants_public |
gen_bf54e51d507a8e793f5e046c9c117647 | Engaging with Local Communities in Botswana: Understanding Cultural Values, norms and Beliefs that may impact Genome-Editing Research in Botswana | Wellcome Trust | University of Botswana | HRCS22_12260 | The continuous growth and recent technical advances that have improved the precision, cost and simplicity of new gene editing technologies such as Somatic and germline therapy have since given birth to new hope in the fight against the burden of disease such as HIV in developing countries (sources). Despite facing dis-proportionally higher prevalence HIV rates, communities in Botswana to our knowledge the technologies have not been tried hence Batswana remain understudied in gene editing research. Therefore, I am proposing a study to engage with local communities to educate them about gene-editing technology research and collect their perspectives on how their cultural values norms and beliefs can have positive or negative implications on their benefiting from this technology. 1. The overall goal of the project is to explore the perceptions of communities in Botswana regarding perceived and real social ethical issues (cultural values, norms and beliefs) surrounding gene-editing technologies regarding its use for health benefits? 2. The project also aims to empower communities with knowledge through education and engagement about gene-editing technology for better informed decisions in preparation for participation in gene-editing technologies as well as learning about its potential benefits, risks and use of genomics, gene-editing technologies. | 8.3 Policy, ethics and research governance | 6project_grants_public |
gen_c2b9422e284f61b4f848075f6ab2dc15 | Bringing data science and AI/ML tools to infectious disease research - a hands-on workshop | Wellcome Trust | H3D Foundation | HRCS22_12443 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_de8c3e4b53024c60eade0737c331d920 | Characterizing the Impact of Antenatal Maternal Anaemia on the Child Brain using Magnetic Resonance Imaging (MRI) in Two South African Birth Cohorts | Wellcome Trust | University of Cape Town | HRCS22_12596 | My research is embedded within two South African birth cohorts with numerous risk factors for poor child development including food insecurity, malnutrition, and anaemia. Preliminary work indicates a 31% prevalence of maternal anaemia. Given that iron deficiency is the most common global cause of anaemia, nutrition is recognised as a health priority to target in educating and empowering communities. I have developed a three-tier public engagement project. The first objective is to run interactive workshops with mothers from study communities. The aim is to identify practical ways to improve research processes, to gain insight into community perceptions and challenges around nutrition, to collaboratively develop key messages and strategies for improved iron intake, and to discuss prospective methods for sharing study outcomes with the wider community. The second objective will focus on using workshop feedback to create accessible, informative, and culturally appropriate resources for dissemination at study sites and more broadly to the South African public. Resources will include posters, pamphlets, and a video aimed at raising awareness and providing practical guidelines around the importance of a nutritious, iron-sufficient diet. The goal is to make these resources accessible via antenatal clinics, study sites, community resource centres, institutional websites, social media platforms, and government endorsed mobile healthcare platforms. Tier three involves sharing research results through academic platforms and community meetings for feedback and discussion with study participants. I also aim to prepare an article for a popular science magazine that is accessible to the general public including the South African youth. | No Research Activity assigned | 6project_grants_public |
gen_1b67f0e2389853295f5c0309011b056d | Saving young lives: Triage and management of sepsis in children using the point-of-care Paediatric Rapid Sepsis Trigger (PRST) tool | Wellcome Trust | University of British Columbia | HRCS22_13150 | Smart Triage represents a significant shift in the care provided at Ugandan health facilities. Previously, children were seen on a first-come, first-serve basis. With Smart Triage, children are stratified by severity of illness to guide prioritization of care to the sickest children. This change in practice is unexpected for families. Sustaining impact beyond our research award will require acceptance and cooperation from caregivers and family of children who present to health facilities and the general public who become participants within this new system. Here we aim to sensitize caregivers and community members to Smart Triage and its impacts on the care provided at Ugandan health facilities. We will host community dialogues with caregivers, community leaders, and Village Health Teams (VHTs) to provide details of the motivation for Smart Triage and outcomes to-date and gain feedback the system. These discussions will inform the development of educational materials on the role of Smart Triage and the importance of triaging in reducing death and improving outcomes for vulnerable children in Uganda. We will engage with VHTs to broadly distribute these materials to caregivers across one district in which we operate. VHTs are trusted community members that serve as link between caregivers and the formalized health care system. We will monitor caregiver awareness of Smart Triage when they arrive at health facilities before and after our campaign to assess impact, and host additional community dialogues to help refine our approach. This approach will then be replicated in more districts. | 7.1 Individual care needs | 6project_grants_public |
gen_0b81112d2002381c7d26f0937fdd73cb | Improving clinical handovers and communication to improve continuity of care for hospitalized small and sick newborns in selected public hospitals in Kenya. | Wellcome Trust | KEMRI Wellcome Trust Research Programme | HRCS22_13437 | Clinical handovers involve transferring patient responsibility and accountability between outgoing and incoming healthcare providers across shifts and disciplines. It has been highlighted as the most vulnerable time in patient care. Communication failures during handovers have been linked to adverse events, jeopardizing patient safety. Many techniques have been used to improve handovers and communication in health care settings in High Income Countries (HICs) often focused on standardizing information transfer. The SBAR (Situation, Background, Assessment and Recommendation) structured handover approach is often regarded as a ‘best practice’ technique in critical care that has led to reductions of medical errors and enhanced safety culture. In LMICs, including Kenya interventions to improve handovers have not been implemented. In this study, focusing on neonatal ward care I propose: i) to systematically review tools used to improve and evaluate effects of handover interventions, ii) explore current Kenyan nurses’ handover practices and develop with them a contextually appropriate tool to improve and standardize handovers and, iii) to conduct a pilot implementation study using mixed methods (focus group discussions and a survey) to assess its potential effectiveness. This fellowship will then provide the preliminary evidence needed to inform the design future funding proposals for larger implementation studies. | 8.1 Organisation and delivery of services | 6project_grants_public |
gen_028d098f9ad83e536bf1154e2ef849f6 | NURTuRE: National Unified Renal Translational Research Enterprise - Geneva University Hospitals | Kidney Research UK | University of Geneva | HRCS22_14608 | No abstract available for this analysis. | HRCS Research Uncodeable | 6project_grants_public |
gen_ee99db15268c14644c11dd57e6048082 | NURTuRE: National Unified Renal Translational Research Enterprise - Geneva University Hospitals | Kidney Research UK | University of Geneva | HRCS22_14727 | No abstract available for this analysis. | HRCS Research Uncodeable | 6project_grants_public |
gen_4376b1a33d7fbfb59554d6d12a71ba2c | Metabolic and Cardiovascular Disease. | Wellcome Trust | University of Cambridge | HRCS22_20518 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public |
gen_aade94a41a134e25aba7175738408146 | Cellular and molecular physiology | Wellcome Trust | University of Liverpool | HRCS22_20531 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public |
gen_ea0ce3078f408b308b47116358f22cad | The molecular basis of biological mechanisms | Wellcome Trust | University of Leeds | HRCS22_20548 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public |
gen_927f97882e564e4f7c8b033aa4323674 | Hosts, Pathogens & Global health | Wellcome Trust | University of Edinburgh | HRCS22_20549 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public |
gen_3ff2ac3f510d64074b67fbd488443c66 | Cellular Structural Biology | Wellcome Trust | University of Oxford | HRCS22_20561 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public |
gen_df47e8da2ec41ae198f29394d6ee3911 | Macromolecular machines: interdisciplinary training grounds for structural, computational and chemical biology | Wellcome Trust | University College London | HRCS22_20573 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public |
gen_3c778241a7ed637086b7c866aba214a3 | Dynamic Cell Biology | Wellcome Trust | University of Bristol | HRCS22_20597 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public |
gen_6a25b00415b7c5282e7dd3dc37524292 | Molecular and Cellular Biology | Wellcome Trust | University of Dundee | HRCS22_20599 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public |
gen_a95f22b13911d87dce22e629979938fb | Genomic medicine and statistics | Wellcome Trust | University of Oxford | HRCS22_20607 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public |
gen_97ab4e7df274892b88100ddd093036a5 | Infection, Immunity and Inflammation | Wellcome Trust | University of Cambridge | HRCS22_20620 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public |
gen_8f3df496c9220c6d96f7abd3432d2ddb | The Dynamics of Cellular Regulatory Networks | Wellcome Trust | University of Manchester | HRCS22_20632 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public |
gen_d7a0bc4bbde97637d30665e0e45eb2e6 | Chromosome and Developmental Biology. | Wellcome Trust | University of Oxford | HRCS22_20638 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public |
gen_b0eea513fabc19b7ce52c15c2261516e | Developmental mechanisms | Wellcome Trust | University of Cambridge | HRCS22_20646 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public |
gen_a067e81f94e7301d2a9a76e1f51989f7 | Standard Approach to atMP tissue ColLEction (Sample) | Innovate UK | The Christie NHS Foundation Trust | HRCS22_21930 | Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details. | Missing/Incomplete | 6project_grants_public |
gen_0fb63fcc1ffdfb6fca04f0a56f1b6689 | DARA Big Data: 2019 Extension | Science and Technology Facilities Council | University of Manchester | HRCS22_22490 | DARA Big Data is building research capacity around Big Data and the fourth industrial revolution in Southern Africa through high quality education and research. These high-value technical skills are applicable not only to scientific research but also to the space sector, as well as numerous other industrial and commercial sectors where diversification, technological upgrading and innovation are key drivers of economic growth. Moreover the key research areas of DARA Big Data are well-aligned both with the UN Global Goals and the African Union 2063 vision for advanced technologies, in order to improve welfare at the same time as targeting economic growth. DARA Big Data provides bursaries for students from the partner countries of the African VLBI Network (AVN) - Botswana, Ghana, Kenya, Madagascar, Mauritius, Mozambique, Namibia and Zambia - to study for MSc(R) and PhD degrees at universities in South Africa and the UK. These degrees are in the three data intensive DARA Big Data focus areas of astrophysics (Astro Big Data), health data (Health Big Data) and sustainable agriculture (Agri Big Data). In addition to providing studentship bursaries, DARA Big Data also works in partnership with South African SKA project (SKA-SA), now incorporated into the South African Radio Astronomy Observatory (SARAO), on the broader Big Data Africa program. Big Data Africa provides training workshops in machine learning, big data techniques and data intensive methodologies across the three DARA Big Data focus areas. These workshops and training courses take place in South Africa and other AVN countries, and are open to students from across the AVN country network who are currently in the honours year of their undergraduate degree or who are already pursuing a masters or PhD level research degree in those countries. | Missing/Incomplete | 6project_grants_public |
gen_2d460e53b3978dda6a48d73053cb01cd | Development of advanced laserwire accelerator diagnostics and laser controlled particle beams | Science and Technology Facilities Council | Royal Holloway University of London | HRCS22_22493 | The proposed research will implement a laserwire at the new FETS accelerator at RAL, to measure the transverse emittance of the high power 3 MeV hydrogen ion beam. The technique will be developed to monitor the longitudinal bunch structure via ultrafast laser pulses. We propose new concepts for laser controlled particle beams, based on the photo-detachment of accelerated ions and the extraction of an adjustable intensity, steerable proton beam, suitable for medical and accelerator applications. | Enterics, Diagnostics, Genomics & Epidemiology / Missing/Incomplete | 6project_grants_public |
gen_39ca68609414b57e8e61183517b86be8 | Gates Foundatoin | Connected DMV | INV-028551 | to identify and help launch strategic projects needed to advance pandemic avoidance and preparedness | Empower Women and Girls / Global Health | 6project_grants_public | |
gen_8d4d18df568a048de83db9900676f78c | Gates Foundatoin | Johns Hopkins University | INV-028791 | to provide technical support to the government of Pakistan and country partners in the domains of nutrition science, implementation research, and program design. | K-12 Education / Gender Equality | 6project_grants_public | |
gen_ca92a97e9b7166d61d83a1d77dade8b3 | Feasibility of implementing an integrated hybrid model of service delivery for AGYW sexual and reproductive health in South Africa | Medical Research Council | Wits Health Consortium (Pty) Ltd | HRCS22_02206 | Adolescent girls and young women face significant health challenges such as HIV infection, unwanted teenage pregnancies and sexually transmitted diseases. However sexual and reproductive health service utilization remains low among this age group. Hence, there is a need to focus on determining optimal service delivery models that are responsive to current barriers faced by AGYW. This study aims to determine the feasibility of implementing an integrated hybrid model of service delivery for adolescent girls and young women (AGYW) sexual and reproductive health (SRH) at selected facilities in South Africa over a 24 month period. The service delivery model proposed will be a hybrid model comprising of both integration of contraceptive, STI/HIV transmission prevention and mental health screening with linkage by health connectors to care services for HIV treatment, PrEP and psychosocial support. Prior to implementing such an intervention, the feasibility of implementation needs to be determined through determining acceptability (client and provider), demand, practicality and adaptations needed. Hence, the principle research questions that the study aims to address include: (1)What level of service integration for SRH already exists at selected health facilities for adolescent girls and young women?, (2) Would an integrated SRH service be acceptable to health care providers and adolescent girls and young women?, (3) Would SRH service integration be practical in terms of time, space, workload, task-shifting, training and resources in a limited resource setting? and (4) What system changes are needed to implement an integrated hybrid model. This study will inform the development of a full trial to implement and evaluate the effectiveness of an integrated hybrid model of service delivery for AGYW SRH at community health care level. | 7.1 Individual care needs / Research Grant | 6project_grants_public |
gen_00abdf225edbabe9d222272db2e2616e | Gates Foundatoin | Oxford University Press | INV-028977 | to support the publication of a supplement issue in Clinical Infectious Diseases on the mortality burden of respiratory syncytial virus (RSV) disease in low- and middle-income countries (LMIC) | K-12 Education / Global Health | 6project_grants_public | |
gen_0e6897bcf68b4f079623590830411724 | Gates Foundatoin | Higher Institute of Population Sciences (ISSP) | INV-016512 | to evaluate & generate learnings in leveraging social protection platforms to increase the uptake of quality RMNCH-N services in urban & peri-urban areas of Ouagadougou towards improving Nutrition and RMNCH outcomes | Early Learning / Gender Equality|Global Development|Global Policy and Advocacy | 6project_grants_public | |
gen_96a550a9673c91d38bef006308dd1f97 | Gates Foundatoin | International Initiative for Impact Evaluation Inc. | INV-024955 | to assess how sanitation-linked livelihoods facilitate the economic and social empowerment of urban poor and vulnerable groups. | Tuberculosis / Global Development | 6project_grants_public | |
gen_64b4d9207215112237d4a5b152df4d6d | Gates Foundatoin | University of North Carolina at Chapel Hill | INV-026327 | to better understand how population and community dynamics can be properly addressed and integrated into the ongoing polio elimination activities being implemented by local health facility staff in Pakistan. | K-12 Education / Global Development | 6project_grants_public | |
gen_03d2182e769ed767395a163f1cdaab1d | Gates Foundatoin | Society for Research on Educational Effectiveness | INV-026584 | to develop culturally responsive and equitable evaluation training for education researchers | Global Education / U.S. Program | 6project_grants_public |
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