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gen_d731ba179338909192f102e915432bd0 | Identifying strategies to reveal genetic results over the lifespan | NIH | BRIGHAM AND WOMEN'S HOSPITAL | 5K99HG012809-02 | PROJECT SUMMARY/ABSTRACT The widespread sequencing of healthy babies is imminent: at least a dozen research projects have recently launched, and several companies offer newborn genetic screening panels. A newborn’s genome can contain health information of relevance across their lifespan — as a baby, later in childhood,... | Other Research-Related | 6project_grants_public |
gen_861f35591d10f3255ff6da55620a4d3a | Continuum of Immune Responses to Cryptococcus neoformans | NIH | UNIVERSITY OF MINNESOTA | 1R01AI176922-01 | Abstract Cryptococcal meningitis (CM), caused by the fungal pathogen Cryptococcus neoformans (Cn), is among the most prevalent HIV/AIDS-associated opportunistic infections and causes 15% of AIDS- related mortality globally. In healthy individuals, exposure to Cn in early childhood results in a pulmonary latent infecti... | Non-SBIR/STTR | 6project_grants_public |
gen_1ab3e0be631f9ad1c154b64ba033fc7e | A platform to identify in vivo targets of covalent cancer drugs in 3D tissues | NIH | SCRIPPS RESEARCH INSTITUTE, THE | 5R33CA281918-02 | Abstract Covalent inhibitors represent some of the most successful drugs in human history, including aspirin and penicillin. Recently, targeted covalent drugs have taken center stage as a compelling approach for achieving major goals in oncology that have proven elusive for more classical reversible small molecules, in... | Non-SBIR/STTR | 6project_grants_public |
gen_e2eea12f200ef73100e35be627b4bdd4 | 5T-IV: photoacoustic needle with beacon pulse for ultrasound guided vascular access with Tool-Tip Tracking and Tissue Typing | NIH | JOHNS HOPKINS UNIVERSITY | 5R61HL168779-02 | Project Summary Vascular access is the most common medical procedure in the world, with over a billion insertions performed annually. In the United States, over 350-million peripheral intravenous (IV) catheters are sold yearly, in addition to millions of central and arterial lines. However, peripheral IV placement ofte... | Non-SBIR/STTR | 6project_grants_public |
gen_e7db4ad5196484dc066c6d072cbf443b | Role of Vitamin C in Low back Pain and Intervertebral Disc Degeneration | NIH | UNIVERSITY OF MINNESOTA | 1R21AT012559-01A1 | PROJECT SUMMARY / ABSTRACT Persistent back pain is a leading cause of disability worldwide and one of the most common reasons pa- tients are prescribed opioids, despite their poor ability to improve function. Chronic back pain threatens our economic health due to high rates of health care utilization and disability and... | Non-SBIR/STTR | 6project_grants_public |
gen_014b9017eb9b5ef3517577517ad5a57c | Macro-level Health Considerations of Community and Criminal Justice System Relationships in North Texas | NIH | HEALTHY TARRANT COUNTY COLLABORATION | 3OT2OD035659-01S1 | Policing and incarceration are root causes of health inequity, but to date, there have been few efforts to intervene on law enforcement practices and the carceral system as structural factors shaping poor health. Addressing this gap, we propose a Community-Led Structural Intervention to Reduce Police-Related Health Ine... | Other | 6project_grants_public |
gen_a25cf7c69ae4fe2868a72f69bedc869e | Interplay of processed diet, gut microbiota, and interferon-linked mucosal immunity in the onset and prevalence of inflammatory bowel disease | NIH | PENNSYLVANIA STATE UNIVERSITY, THE | 1R01DK133334-01A1 | PROJECT SUMMARY/ABSTRACT Environmental factors including diet and gut microbiota profoundly impact the host resistance and susceptibility towards intestinal inflammation. A high intake of ultra-processed foods enriched with refined starch, sugar, protein, and hydrogenated fat and low in whole grain contents increases ... | Non-SBIR/STTR | 6project_grants_public |
gen_63d5ab7ecee63c727dc988dbd9bb0ae2 | Tracing spatial organization of germinal centers in rhesus macaques | NIH | GEORGIA INSTITUTE OF TECHNOLOGY | 5R21OD035574-02 | Germinal centers (GCs) are the microstructural sites in secondary lymphoid organs, but GC structures are impaired in AIDS patients due to the loss of supporting CD4+ T cells, leading the deficiencies in immune responses and even inefficacies in antiretroviral therapies in HIV-infected individuals. To solve this challen... | Non-SBIR/STTR | 6project_grants_public |
gen_239a70a8ad568e1a572685ca4d2e5a17 | A Healthy Weight Intervention for Family Stress during the Early Phases of ALL Treatment: NOURISH-ALL | NIH | UNIVERSITY OF KANSAS MEDICAL CENTER | 1K08CA279877-01A1 | PROJECT SUMMARY/ABSTRACT Excessive weight gain leading to obesity is common during the early phases of pediatric acute lymphoblastic leukemia (ALL) treatment, and results in higher risk of relapse, lower event-free survival rates, and more adverse events during treatment. Yet, effective preventive interventions for exc... | Other Research-Related | 6project_grants_public |
gen_ac87465e493f699b21a363fe22f1a2d0 | Evaluation of Cancer Health Activism Network for Greater Equity (CHANGE) | NIH | RICE UNIVERSITY | 5R25GM150177-02 | The Cancer Health Activism Network for Greater Equity (CHANGE) project addresses inequities in education and health outcomes for African American students in biosciences by enhancing biology teachers' cancer research and cancer health disparities knowledge and developing and implementing transformative, innovative, soc... | Other Research-Related | 6project_grants_public |
gen_e99f4effd9db13145ed99d5392bb9d93 | Smart Cuff: Multi-Parameter Hemodynamic Monitoring via a Single Convenient Device | NIH | UNIVERSITY OF PITTSBURGH AT PITTSBURGH | 5R01HL163691-02 | PROJECT SUMMARY/ABSTRACT Multi-parameter hemodynamic monitoring is needed to manage surgical and intensive care patients. Monitoring blood pressure (BP), cardiac output (CO), and left ventricular ejection fraction (EF), in particular, permits detection of frequent hypotension and hemodynamic instability, diagnosis of t... | Non-SBIR/STTR | 6project_grants_public |
gen_ee63369ca4023619612b9d691380b440 | Targeting RAGE in tumor and TME to oppose inflammation and drug resistance in obesity associated ER+ breast cancer | NIH | GEORGETOWN UNIVERSITY | 1R01CA276587-01A1 | PROJECT SUMMARY/ABSTRACT Obesity is associated with increased postmenopausal estrogen receptor-positive (ER+) breast cancer (BC) risk and a 2-4 fold increase in mortality from all BC subtypes. Mechanisms of increased resistance to therapy and ensuing fatal BC metastasis in obesity remain unclear. Here, we study how th... | Non-SBIR/STTR | 6project_grants_public |
gen_a5d5c02030bd093c46f5900cbcbff289 | Augmenting cancer checkpoint immunotherapies via microbially-derived metabolites | NIH | UNIVERSITY OF CALIFORNIA-IRVINE | 1K22CA272915-01 | PROJECT SUMMARY/ABSTRACT Immune checkpoint inhibitors (ICIs) have significantly improved long-term survival across diverse cancer types including melanoma, non-small cell lung cancer, triple negative breast cancer, and others. However, ICI efficacy relies on multiple cancer, host, and environmental variables, and only ... | Other Research-Related | 6project_grants_public |
gen_c1980a1637ccce3868daf537960297c7 | Temporal trends in quality indicators of palliative care for patients with chronic illness hospitalized with acute respiratory failure | NIH | UNIVERSITY OF WASHINGTON | 5F32HL167667-02 | PROJECT SUMMARY/ABSTRACT Patients with chronic illness who develop acute respiratory failure face significant morbidity and mortality, with survivors often suffering serious physical and psychological sequelae. These patients have a critical need for palliative care. Palliative care is focused on improving quality of l... | Training, Individual | 6project_grants_public |
gen_4952cf517db0051d57faaac4ed8b2734 | Addressing perinatal mood and anxiety disorders (PMADs) through a doula intervention | NIH | UNIVERSITY OF MONTANA | 5P20GM130418-04 | Perinatal mood and anxiety disorders (PMADs) have intergenerational negative impacts on the physical and mental health of women and their families and are the most frequently experienced childbirth complication. PMADs are particularly common in rural populations, who experience additional obstacles in accessing mate... | Research Centers | 6project_grants_public |
gen_546bf726bb35d6a8385ba6b75967aea6 | Geospatial food access as a driver of environmental oxidant stressors and early obesity | NIH | NEW YORK UNIVERSITY SCHOOL OF MEDICINE | 1K23ES035461-01 | PROJECT SUMMARY/ABSTRACT Racial/ethnic and socioeconomic disparities in obesity begin early in life. Excessive caloric imbalance in pregnancy is a leading suspected contributor to early weight disparities. Yet, prior studies have not accounted for how limited food access may also drive chemical and psychosocial exposur... | Other Research-Related | 6project_grants_public |
gen_4240916a3f15a2703b3505801fdc816a | Interplay between reverse transcription and host restriction | NIH | UNIVERSITY OF ILLINOIS AT CHICAGO | 5R01AI174538-02 | Infectious agents have infected prokaryotes and eukaryotes throughout evolution. Indeed, there is co-evolution of organisms and their infectious agents, with development of protective responses in the hosts and adaptive countermeasures by the infectious agents. Infectious endemic retroviruses like murine leukemia virus... | Non-SBIR/STTR | 6project_grants_public |
gen_44a8e084edf8d564e07aff8d44df5a14 | Establishment of a Cell-Based Screening Platform for DNA Encoded Libraries | NIH | UNIVERSITY OF FLORIDA | 1R21GM149993-01 | Project Summary DNA-encoded library (DEL) technology has revolutionized the discovery of protein- binding small molecules. However, traditional DELs, where every molecule is connected to an encoding DNA and the library is produced as an intractable mixture, have not been useful for functional and phenotypic screening. ... | Non-SBIR/STTR | 6project_grants_public |
gen_9728fdd121dbbf2cac509bc58725f570 | Integrating liquid biopsy-based epigenetic and imaging modalities to evaluate disease response in multiple myeloma | NIH | UNIVERSITY OF CHICAGO | 1R01CA280637-01 | PROJECT SUMMARY Multiple myeloma (MM) affects ~35,000 adult patients in the United States and causes ~12,000 deaths each year. Novel immunomodulatory drugs and effective multidrug combinations have improved the prognosis for patients, but the vast majority of patients eventually relapse. Even among patients achieve a c... | Non-SBIR/STTR | 6project_grants_public |
gen_e0e7e9c1a4777510ca656ef235c7185a | Mobile Health and Oral Testing to Optimize Tuberculosis Contact Tracing in Colombia | NIH | YALE UNIVERSITY | 5R21AI174129-02 | PROJECT SUMMARY Nearly one-third of the 10 million annual tuberculosis (TB) cases worldwide are missed each year. TB contact tracing is an evidence-based practice that is internationally recommended for finding, treating, and preventing TB among close contacts of TB patients. Contact tracing is also considered a highly... | Non-SBIR/STTR | 6project_grants_public |
gen_760a987ba34bdb9a8d938e27ceee0637 | SCH: Simulation Optimization of Cardiac Surgical Planning | NIH | UNIVERSITY OF TENNESSEE KNOXVILLE | 1R01HL172292-01 | Many patients take surgical interventions to fight the battle against heart disease. Surgical successes are critical to the patients’ health and their family well-being. For e.g., atrial fibrillation (AF) is the most common arrhythmia in elder population. Catheter ablation is an established treatment for AF, which sequ... | Non-SBIR/STTR | 6project_grants_public |
gen_b2d39414742fae45b5f1563462fc3da1 | Proteomic and integrative omic profiles of sugar- and artificially sweetened beverage consumption and changes in type 2 diabetes risk factors | NIH | BRIGHAM AND WOMEN'S HOSPITAL | 1K01DK136968-01 | PROJECT SUMMARY: Type 2 diabetes (T2D) is caused both by genetic and environmental factors, such as diet, as well as the complex interactions between them. While diet is the cornerstone for T2D prevention, dietary interventions are often difficult to implement and monitor due to limitations in dietary assessment techni... | Other Research-Related | 6project_grants_public |
gen_6ab100d76c2cd7b2bdfbe0898cf9e631 | An Alternative Pathobiology underlying Severe Asthma | NIH | UNIVERSITY OF PITTSBURGH AT PITTSBURGH | 1K08HL164887-01A1 | Project Abstract This application is for a Mentored Patient-Oriented Research Career Development Award entitled “An Alternative Pathobiology underlying Severe Asthma.” I am an Assistant Professor of Medicine at the University of Pittsburgh seeking additional training in benchtop murine research techniques and bioinform... | Other Research-Related | 6project_grants_public |
gen_025cd18750a27c3d0b05db64203ac8c2 | Structural-Transcriptional Relationships that Improve Y537S Estrogen Receptor Antagonism | NIH | LOYOLA UNIVERSITY CHICAGO | 1R37CA279341-01 | Summary This proposal studies how drug-induced structural changes to Y537S estrogen receptor alpha (ERα) impact anti- tumoral activities in hormone-resistant breast cancer cells. Breast cancer is the second leading cause of cancer death in the United States. Acquired resistance to hormone therapies is a leading contrib... | Non-SBIR/STTR | 6project_grants_public |
gen_0bd1b84a2ce8980c6bcdc479cb59a693 | Examining the multilevel factors on quality of end-of-life care among cancer patients in Puerto Rico | NIH | UNIVERSITY OF PUERTO RICO MED SCIENCES | 5P20GM148324-02 | PROJECT SUMMARY/ABSTRACT In the United States (US) and Puerto Rico (PR), cancer is the second leading cause of death. Considering that the population is aging, an increase in the burden of cancer is expected in future years. Consequently, quality of care at the end of life (EoL) is critical for dying cancer patients an... | Research Centers | 6project_grants_public |
gen_fa61cf0bebfe15843beec0cada262213 | Sit-and-wait pathogens: Consequences of heterogeneity in pathogen exposure dynamics for environmentally persistent pathogens | NIH | VIRGINIA POLYTECHNIC INST AND ST UNIV | 1R01GM152978-01 | Transmission is a fundamental component of host-pathogen systems. Despite complex biological processes interacting to determine whether a pathogen successfully infects a host, transmission parameters often assume a constant per-contact transmission probability. Factors that can influence risk of infection include th... | Non-SBIR/STTR | 6project_grants_public |
gen_3a3f343be1a6a6c91b1193c717fd1a5d | Pathogenesis of Restrictive Allograft Syndrome Post-Lung Transplantation | NIH | EMORY UNIVERSITY | 7R01HL162171-03 | PROJECT SUMMARY/ABSTRACT Restrictive allograft syndrome (RAS) is a particularly aggressive form of chronic rejection post-lung transplantation, marked by an extremely poor prognosis (median survival of < 1 year) and little therapeutic options. Pathogenesis of RAS remains elusive although association with donor specific... | Non-SBIR/STTR | 6project_grants_public |
gen_e8ab680233030fd63dcd694b882e7bda | Innate immune regulation of wound re-epithelialization | NIH | UT SOUTHWESTERN MEDICAL CENTER | 5R00AR072780-04 | PROJECT SUMMARY/ABSTRACT Skin has a remarkable ability to heal wounds through re-epithelialization, a repair process fueled by adult stem cells residing in the epidermis and hair follicles. Following injury, wound-edge keratinocytes proliferate and migrate to initiate wound closure, which is accompanied by activation a... | Non-SBIR/STTR | 6project_grants_public |
gen_08c5bf95eac90725e5344f4b4c8d4a44 | Understanding Chirality at Cell-Cell Junctions With Microscale Platforms | NIH | RENSSELAER POLYTECHNIC INSTITUTE | 1R01GM141387-01A1 | The regulation of cell-cell junctions is essential for the biological functions of various tissues such as epithelium and endothelium. Recent evidence in embryonic development and vascular physiology suggests that cell-cell junctions are regulated by cell chirality, a universal but fundamental property of the cell. We ... | Non-SBIR/STTR | 6project_grants_public |
gen_49583e64d7c7a300530c38863ab3d768 | Administrative and Biostatistics Core | NIH | SALK INSTITUTE FOR BIOLOGICAL STUDIES | 5P01CA265762-02 | PROJECT SUMMARY – Administrative and Biostatistics Core The overall goal of the Administrative and Biostatistics Core (Admin Core) is to facilitate research efforts toward understanding intrinsic resistance to therapy in pancreatic ductal adenocarcinoma (PDA). This will be accomplished by providing the three Research P... | Non-SBIR/STTR | 6project_grants_public |
gen_d985cdeac35e43129af03bcbd8ef5e5f | Improving vaccination against type-2 T-independent antigens | NIH | ROSALIND FRANKLIN UNIV OF MEDICINE & SCI | 5R21AI176124-02 | Summary Infections with encapsulated bacteria are responsible for the death of millions of children and the elderly each year. Capsular polysaccharides behave as T-independent antigens (TI) and vaccination based on these carbohydrates provides protection against these infections. The efficacy of vaccines against TI ant... | Non-SBIR/STTR | 6project_grants_public |
gen_ac8a0c91447bec0f275d07f37255f48d | The regulation of phosphoprotein phosphatases in the nucleus | NIH | UNIVERSITY OF CONNECTICUT SCH OF MED/DNT | 5R01GM144379-02 | ABSTRACT An estimated 70% of all eukaryotic cellular proteins are regulated by phosphorylation. Strict temporal and spatial control are essential for the fidelity of this process, as derailed signaling cascades lead to disease. While the importance of phosphorylation is clear, knowledge gaps remain in the mechanisms th... | Non-SBIR/STTR | 6project_grants_public |
gen_bba59e927cd5ed115c8aae8cbfc98258 | Modeling the dynamics and composition of T-cell receptor repertoires in post-acute sequelae of COVID-19 (PASC) | NIH | INSTITUTE FOR SYSTEMS BIOLOGY | 1R03AI175977-01A1 | Project Summary Post-acute sequelae of COVID-19 (PASC), colloquially known as long covid, has been reported in 31%-69% of COVID-19 patients. The prevalence of PASC among patients, even those with mild infection, and those with prior vaccination, underscores the importance of principled approaches for uncovering and add... | Non-SBIR/STTR | 6project_grants_public |
gen_5cbf93ae6efc758ca80be0648af07528 | Assessing the Impact of SARS-CoV-2 on Adipose Tissue Function and Glucose Homeostasis | NIH | WEILL MEDICAL COLL OF CORNELL UNIV | 3R01DK132879-01A1S1 | Project Summary/Abstract COVID-19 has proven to be a metabolic disease resulting in adverse outcomes disproportionally afflicting individuals with diabetes or obesity. Patients infected with SARS-CoV-2 and hyperglycemia suffer from longer hospital stays, increased need for mechanical ventilation and mortality compared ... | Non-SBIR/STTR | 6project_grants_public |
gen_78f0d6789225ecaa56fdabeba3d41865 | An in vivo multiplex model to study gene-environment interaction in Parkinson's Disease | NIH | UNIVERSITY OF ROCHESTER | 3R00ES033723-03S1 | Project Summary/Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized by α-synuclein-rich neuronal inclusions. Recent genome-wide associated studies (GWAS) and epidemiological studies have identified multiple candidate genes and environmental factors which can modify PD ris... | Non-SBIR/STTR | 6project_grants_public |
gen_9bd58a99e4d21d1c355371c9a381446c | Composing CODAs to cervical cancer screening through an integrated CRISPR and fluorescent nucleic acid approach | NIH | MASSACHUSETTS GENERAL HOSPITAL | 5U01CA279858-02 | ABSTRACT Challenges. Despite being curable when caught early, cervical cancer remains the second leading cause of death in women living in sub-Saharan Africa. Even with available screening technologies (cytology, visual inspection with acetic acid (VIA), and sometimes high-risk Human Papillomavirus [hrHPV] testing), on... | Non-SBIR/STTR | 6project_grants_public |
gen_2956ae1404c7a8b9f59c4c2c49f27761 | Interrogating function, regulation, and interactions in a clade of prevalent human gut microbes | NIH | OHIO STATE UNIVERSITY | 5R35GM151155-02 | PROJECT SUMMARY/ABSTRACT Human-associated microbes are causally linked to processes as diverse as immunomodulation, protection against pathogens, and atherosclerosis. Many of these links are mediated through biochemical transformations of dietary, drug, or host compounds. This makes the microbiome a promising therapeut... | Non-SBIR/STTR | 6project_grants_public |
gen_facb5416f7ba2ad509fba54bb4204df3 | In vivo Evaluation of Lymph Nodes Using Quantitative Ultrasound | NIH | WEILL MEDICAL COLL OF CORNELL UNIV | 5R01CA277038-02 | Project Summary This application proposes a collaborative study to be performed by Weill Cornell Medicine (WCM) in New York, NY, as the lead organization in collaboration with GE Research (GER) in Niskayuna, NY, and Stony Brook Medicine (SBM) affiliated with the State University of New York in Stony Brook, NY. The prop... | Non-SBIR/STTR | 6project_grants_public |
gen_734bd2af99b4b8c313c924535b9fadaa | Endothelial Metabolic Reprogramming by Interferon-gamma in Coronary Artery Disease | NIH | BRIGHAM AND WOMEN'S HOSPITAL | 5K08HL165047-02 | PROJECT SUMARY/ABSTRACT This proposal presents a five-year research and training program to establish Laurel Y. Lee, M.D., D.Phil. as an independent, R01-funded physician-scientist in academic cardiology with expertise in immune modulation of endothelial metabolism in atherosclerosis. This unique scientific focus combi... | Other Research-Related | 6project_grants_public |
gen_5950eb47b0079bdc6ed85473006db1bd | Development and Evaluation of Advanced Non-Contrast Perfusion MRI for Monitoring Treatment Response in Brain Metastases | NIH | JOHNS HOPKINS UNIVERSITY | 1R01CA282928-01 | Project Abstract Brain metastases (BM) are the most commonly diagnosed type of central nervous system tumor, more frequent than primary intracranial neoplasms. Progress on various therapies have accelerated over the past decade through ongoing clinical trials, and the historically poor outcomes for patients with BM ha... | Non-SBIR/STTR | 6project_grants_public |
gen_50c47b069b83b653b987a4f795969c0d | Team Support to Improve Glycemic Control Using CGM in Diverse Populations (TEAM CGM) | NIH | UNIV OF MASSACHUSETTS MED SCH WORCESTER | 5R01DK133265-02 | PROJECT SUMMARY Continuous glucose monitoring (CGM) has demonstrable benefits for people living with diabetes, including improvement in diabetes control and reduction in hypoglycemia. Randomized controlled trials have demonstrated that CGM can reduce hemoglobin A1c (HbA1c) and increase in the time in range (TIR) metric... | Non-SBIR/STTR | 6project_grants_public |
gen_d797bc475ecbe97b23b95f600578e138 | Structural and functional basis of bacterial transcriptional regulation | NIH | LEHIGH UNIVERSITY | 1R35GM150644-01 | Project Summary / Abstract Antibiotic resistance poses an increasingly prevalent public health challenge, but advances in the development of new drugs has not progressed commensurately. A significant impediment lies in that many fundamental biochemical processes in bacteria remain poorly understood. The primary goal o... | Non-SBIR/STTR | 6project_grants_public |
gen_3dfe84b061865341d3dc5bc536e23ba2 | Investigating Behavioral Mechanisms and Efficacy of a Provider-Directed Intervention for HPV Vaccine Promotion in Real-World Dental Settings | NIH | HEALTHPARTNERS INSTITUTE | 5UG3DE030063-02 | Project Summary Human papillomavirus (HPV) is the leading cause of oropharyngeal cancers in the US. Despite the safety and effectiveness of the HPV vaccine (HPV-V), coverage is far below that for other routine adolescent vaccines and the Healthy People 2030 goal of 80%. HPV-V promotion at dental visits is seen as a pri... | Non-SBIR/STTR | 6project_grants_public |
gen_bfb6d207a7de183fbd6bd5b55a702c8b | Children's Oncology Group | NIH | UNIVERSITY OF SOUTHERN CALIFORNIA | 3U10CA180899-10S1 | PROJECT SUMMARY Since the introduction of chemotherapy for the treatment of childhood leukemia more than 60 years ago, the prognosis of childhood cancer has improved dramatically. The overall 5-year survival rate for childhood cancers, many of which were uniformly fatal in the pre-chemotherapy era, is now 84%. Progress... | Other Research-Related | 6project_grants_public |
gen_3a9e29c825b1e524b6ce58d7286a318f | Dysregulation of Epithelial Metabolism and Regeneration by Sulfite Exposure in Pediatric Ulcerative Colitis | NIH | STANFORD UNIVERSITY | 5K99DK136971-02 | PROJECT SUMMARY The prevalence of ulcerative colitis (UC) in children continues to increase yearly. Recent evidence in pediatric UC patients showed significant mitochondrial impairment in the colon tissues. This is important as optimal mitochondrial activity is required for the solemn function of colonic stem cells tha... | Other Research-Related | 6project_grants_public |
gen_8af4307e8f456cd2f4e522187746d0fc | DMS/NIGMS 1: Multiscale modeling of Notch signaling during long-range lateral inhibition | NIH | CLARKSON UNIVERSITY | 5R01GM152810-02 | The spatiotemporal distribution of morphogens contributes to the organized development of tissues and organs. One model of morphogen distribution is active transport, which includes cell based mechanisms like signaling filopodia. Signaling filopodia facilitate contact between distant cells in order to allow signaling... | Non-SBIR/STTR | 6project_grants_public |
gen_1f1c62ae1c4b6604adeb54867efa0ab2 | In-vivo Assessment of Neuroinflammation in Painful Trigeminal Neuropathy | NIH | MASSACHUSETTS GENERAL HOSPITAL | 1R21DE031410-01A1 | Painful trigeminal neuropathy (PTN) is defined as facial pain in the distribution(s) of one or more branches of the trigeminal nerve, associated with neural damage induced by trauma, viral infection, or other causes. PTN is very unresponsive to medical and surgical treatments. Clearly, a more in-depth knowledge of the ... | Non-SBIR/STTR | 6project_grants_public |
gen_89d9b5eca44aed98cbbfd4964eb1f197 | Structure-based inhibition of chemokine signaling in the inflamed pancreas | NIH | MEDICAL COLLEGE OF WISCONSIN | 5R01DK133247-02 | Modified Project Summary/Abstract Section The goal of this project is to establish the role of CCL28 in chronic pancreatitis and use structure-based drug discovery methods to identify small molecule inhibitors of this secreted protein. CCL28 is a mucosal chemokine that promotes tumor growth in a variety of organs by r... | Non-SBIR/STTR | 6project_grants_public |
gen_b92f76df87a8968dbe6ca1238c2b1781 | Age Differences and Mechanisms of Ketogenic Diet Induced Bone Loss | NIH | UNIVERSITY OF CALIFORNIA AT DAVIS | 5K99AR081401-02 | Project Summary Ketogenic diet (KD), a high fat low carbohydrate diet is used to treat intractable epilepsy, is becoming increasingly popular for weight management, and it can potentially slow cognitive ageing and alleviate symptoms of neurological disorders such as stroke, Parkinsons disease, and Alzheimers. However, ... | Other Research-Related | 6project_grants_public |
gen_dbf664ecc4d9500fef1cb70ed986bc03 | Access for All in ALS (ALL ALS) West Clinical Coordinating Center | NIH | ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER | 3OT2NS136939-01S1 | Abstract Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, ultimately fatal, neurodegenerative disease with approximately 32,000 cases in the United States (US). With an estimated lifetime risk of 1/400, an average of 5,000 new US cases are diagnosed every year. A public private partnership (PPP) can be lev... | Other | 6project_grants_public |
gen_fb19479292a3fec4f3815e79ef477573 | Maximizing tumor responses to targeted radiotherapy with a conditionally activated membrane binding probe | NIH | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | 1R01CA279328-01A1 | Project Abstract: The recent FDA approvals (Lutathera, Azedra, Pluvicto) and the swell of promising experimental agents in clinical trials underscore the surging enthusiasm to investigate molecularly targeted radiotherapy (TRT) as a treatment modality for cancers. However, tumor responses to TRTs are often transient an... | Non-SBIR/STTR | 6project_grants_public |
gen_07bf905f04d124a3053d26734d6e9569 | Investigating mechanisms of oxidized phospholipid-mediated dysregulation of regulatory T cells in atherosclerosis | NIH | VANDERBILT UNIVERSITY MEDICAL CENTER | 1R21AI176219-01 | SUMMARY The important role of adaptive immunity in cardiovascular disease (CVD) is established. However, much is still unknown regarding how adaptive immunity can be manipulated to benefit CVD outcomes. Atherosclerosis, the most common form of CVD, is characterized by accumulation of lipid and immune cells in the arter... | Non-SBIR/STTR | 6project_grants_public |
gen_4aea3d01a372c2fa2d3a1b2fde3c8f06 | VRC Inhibiting p38 to Prevent and Restore Corneal Scarring | NIH | SCHEPENS EYE RESEARCH INSTITUTE | 1R01EY035947-01 | Project Summary Research Idea/Rationale: Corneal scarring (or fibrosis) from corneal puncture injury or laceration is one of the leading etiologies for blindness. Currently, none of the potential treatments for corneal fibrosis have been FDA- approved and none have been shown to reverse an existing corneal scar. Ther... | Non-SBIR/STTR | 6project_grants_public |
gen_dbf5f7e645b28dfef713c5e7cfd12c5b | DiversitySupp-ONES-Prenatal Phthalate Exposure | NIH | SEATTLE CHILDREN'S HOSPITAL | 3R01ES033785-01A1S1 | Project Summary Spontaneous preterm birth (sPTB) comprises the majority of preterm births (60%) and is a leading case of newborn morbidity and death and a predictor of adverse health outcomes. Despite its high prevalence, there is a limited understanding of how the in-utero environment contributes to the etiology of sP... | Non-SBIR/STTR | 6project_grants_public |
gen_eaebaaa965bb7b7dfb2051aab516faf3 | Dissecting the complex role of microglia states in glaucoma | NIH | UNIVERSITY OF ROCHESTER | 1R01EY035093-01 | Glaucoma is a very common age-related neurodegenerative disease characterized by the death of the retinal ganglion cells. Despite its prevalence, there are no neuroprotective treatments for glaucoma. The only current treatment is lowering intraocular pressure which unfortunately does not prevent or restore vision loss ... | Non-SBIR/STTR | 6project_grants_public |
gen_626d93cbe2761a044fb9275b928dea42 | The role of adaptive immunity in organophosphate induced CNS injury | NIH | ROSKAMP INSTITUTE, INC. | 5R21NS131162-02 | Chlorpyrifos (CPF) is an organophosphate (OP) pesticide, classified as a chemical threat agent by the Department of Homeland Security because it can cause neurotoxicity if released into the civilian populations. Under these circumstances, CPF and similar OP chemicals have a potential to cause long-term chronic multi sy... | Non-SBIR/STTR | 6project_grants_public |
gen_57739f81773cb9e1b31126260788d861 | Dysregulated neutrophil subpopulations as a driving mechanism of liver and gastrointestinal disease in HIV-1-infected individuals | NIH | UNIVERSITY OF ALABAMA AT BIRMINGHAM | 5R01DK135413-02 | 7. PROJECT SUMMARY / ABSTRACT. Gastrointestinal (GI) mucosal damage and destruction of the gut epithelial barrier are the defining features of the pathogenesis of HIV-1 infection. Accumulated evidence indicates that neutrophils play a critical role in the gastrointestinal and liver damage in HIV-1 infection. Neutrophi... | Non-SBIR/STTR | 6project_grants_public |
gen_fa5dd5828e01036e27bb4a9acd215fa4 | Monoclonal Antibody to Combat Pseudomonas Aeruginosa | NIH | EMORY UNIVERSITY | 5R01AI176545-02 | PROJECT SUMMARY/ ABSTRACT. Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen that infects immunocompromised individuals, especially in the hospital setting. This bacterium is an important pathogen in people with weakened immune systems, injuries, and other underlying physiologic dysfunctions. P. aerugin... | Non-SBIR/STTR | 6project_grants_public |
gen_b262bb005cfb9841e5694f8f8724fc7d | Outreach Core | NIH | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 1U54CA285115-01 | PROJECT SUMMARY/ ABSTRACT – OUTREACH CORE The Cancer Research and Education to Advance HealTh Equity (CREATE) Partnership’s geographic area is composed of San Diego and Imperial Counties, the two U.S.-Mexico border counties in California which include ~3.5 million residents. This region is a majority-minority area, wit... | Research Centers | 6project_grants_public |
gen_ff073d6a300e3428df30e17b0cccc000 | Characterizing Vision Impairment and Its Impact on Independence in Older Adults | NIH | UNIV OF NORTH CAROLINA CHAPEL HILL | 5R01EY033907-02 | ABSTRACT Vision impairment (VI) is a significant public health problem among older adults. VI impacts a broad range of activities and is associated with reduced quality of life and poorer physical and mental health. As the population is aging, VI will become an increasingly important problem. Yet, data on VI in the old... | Non-SBIR/STTR | 6project_grants_public |
gen_a66cdf22b4d44cec7df97f3bfb00e9c1 | Rationally guided discovery platform for monoclonal antibodies against carbohydrate antigens using virus-like particle conjugate immunization and high throughput selection | NIH | MICHIGAN STATE UNIVERSITY | 5R21AI174001-02 | This project will establish a protein engineering platform for evolving monoclonal antibody binding affinity and specificity to solve the notorious challenge of developing clinical mAbs against tumor associated carbohydrate antigens (TACAs). Our central hypothesis is that the merger of Qβ carrier protein-elicited mAb d... | Non-SBIR/STTR | 6project_grants_public |
gen_cf2db1b0a36f138fbc6517e82c50320a | Mechanisms of action and therapeutic targeting of the CARM1-NFIB axis in small cell lung cancer | NIH | UNIVERSITY OF TX MD ANDERSON CAN CTR | 1R01CA272843-01A1 | ABSTRACT Treatment options for small cell lung cancer (SCLC) patients have remained largely unchanged for 3 decades, with no new FDA-approved treatments for 20 years, and no targeted therapies. We recently performed a screen for targets of an arginine methyltransferase called CARM1 and identified the NFI family of tran... | Non-SBIR/STTR | 6project_grants_public |
gen_cb25cb342a613ecda4a0d0520da034c0 | Interferon regulation of gamma delta intraepithelial lymphocyte activation | NIH | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | 7R01DK119349-05 | PROJECT SUMMARY. Immune surveillance at mucosal barriers is essential to provide an immediate defense against invasive microbes, yet must also be tightly regulated limit the potential for autoimmunity. Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) bridge innate and adaptive immunity, and functi... | Non-SBIR/STTR | 6project_grants_public |
gen_94f0bb2f3c0ec71f8268237bfaed0cbf | Dietary modulation of Paneth cells | NIH | WASHINGTON UNIVERSITY | 1R01DK136829-01 | ABSTRACT One of the underappreciated effect of obesity is the repression of gut innate immunity, as we recently showed in overweight/obese patients, using Paneth cell phenotype (as a surrogate for Paneth cell function) as a proof- of-concept. Wild type mice fed with western diet (WD) also developed Paneth cell defects.... | Non-SBIR/STTR | 6project_grants_public |
gen_f4245b59d16be93506e9f43f768d7976 | Cancer-based discovery of novel mechanisms of chromatin control | NIH | ST. JUDE CHILDREN'S RESEARCH HOSPITAL | 5R01CA273455-02 | Project Summary/Abstract: The systematic sequencing of cancer genomes has revealed a high prevalence of mutations in genes encoding chromatin regulatory proteins. Of these aberrations, mutations in genes encoding subunits of SWI/SNF (BAF) chromatin-remodeling complexes are the most frequent, collectively occurring in o... | Non-SBIR/STTR | 6project_grants_public |
gen_0138e22ebc9004e75dc2f37c64b25384 | The effects of masculinizing gender-affirming hormone therapy for transgender men on susceptibility to HIV-1 infection modelled ex vivo in cervical mucosal tissue | NIH | UNIVERSITY OF ALABAMA AT BIRMINGHAM | 5R21AI178872-02 | PROJECT SUMMARY/ABSTRACT There are approximately 1.3 million transgender adults in the US, and about 467,000 of these individuals (~36%) are transgender men. Transgender men are individuals who were assigned female at birth but identify as male. Trans men may transition physiologically from female to male by receiving ... | Non-SBIR/STTR | 6project_grants_public |
gen_08fa50e713a6dde3970dc9f73004ff9f | Exploiting Carbon Monoxide Biofoams to Radio-Sensitize Rectal Cancer Cells While Protecting Normal Bowel | NIH | UNIVERSITY OF IOWA | 5K08CA276908-02 | ABSTRACT An estimated 45,230 individuals were diagnosed with rectal cancer in the United States in 2021. Rectal cancer is primarily managed using a combination of chemotherapy, radiation, and surgery. Surgical resection of the rectum is associated with long-term functional deficits and decreased quality-of-life. Theref... | Other Research-Related | 6project_grants_public |
gen_98e6076980628c308cf50088779c73cc | Molecular basis of plasma membrane rupture in lytic cell death and its inhibition by cytoprotective agent glycine | NIH | CASE WESTERN RESERVE UNIVERSITY | 5R35GM151043-02 | PROJECT SUMMARY/ABSTRACT Plasma membrane rupture (PMR) in lytic cell death—including pyroptosis, necroptosis, and post-apoptotic secondary necrosis—is a cataclysmic event that releases large-size intracellular molecules known as damage- associated molecular patterns (DAMPs), which in turn propagate the inflammatory res... | Non-SBIR/STTR | 6project_grants_public |
gen_a95c2c856af8aef1771d7e69e60c883a | Interactions between Trichuris and the gut microbiota | NIH | UNIVERSITY OF PENNSYLVANIA | 5R01AI179896-02 | PROJECT SUMMARY Parasitic nematodes colonize over a billion people worldwide and are associated with a range of maladies. Among these parasites, the whipworm Trichuris trichiura is particularly difficult to manage with existing medication that target adult worms due to drug resistance and frequency of reinfection. Foll... | Non-SBIR/STTR | 6project_grants_public |
gen_fabbe23f9178a1c014c2ae5fcda78f48 | Exploration of the immunosuppressive function of RBMS3/PRRX1 axis in TNBC | NIH | WAYNE STATE UNIVERSITY | 1R21CA273771-01A1 | Abstract The epithelial to mesenchymal transition (EMT), a developmental process related to tissue repair and pathological processes, has been found to occur in the progression of carcinomas to invasive and metastatic disease. Accumulated evidence suggests the EMT could contribute to the immunosuppressive function of c... | Non-SBIR/STTR | 6project_grants_public |
gen_c4874b6f3d7faf286594fad8ab58cea0 | Crosslinking-based targeted therapy for triple-negative breast cancer | NIH | ARIZONA STATE UNIVERSITY-TEMPE CAMPUS | 1R21CA280458-01 | Abstract The HER1 and/or HER3 receptors are overexpressed in most triple-negative breast cancers (TNBCs), a subtype of breast cancer that lacks estrogen receptor, progesterone, and HER2 expression and is associated with poor prognosis and a high lung and brain metastasis rate. Chemotherapy is the mainstay of TNBC trea... | Non-SBIR/STTR | 6project_grants_public |
gen_1ef4c00da2f313df83922900cacdecd5 | Neuronal Regulation of Skeletal Development and Repair | NIH | UNIVERSITY OF MARYLAND BALTIMORE | 7R01DE031028-08 | This is a renewal application of a program investigating the role of sensory nerves in bone. Our studies during the first funding period demonstrate that NGF-dependent TrkA signaling by sensory nerves is the primary driver of angiogenesis and osteogenesis in the developing femur and skull. In these avascular settings, ... | Non-SBIR/STTR | 6project_grants_public |
gen_84e77cb31d319846d8947c856abbe42e | More Outside Your Door (MOYD) | NIH | ALASKA NATIVE TRIBAL HEALTH CONSORTIUM | 5R01HL168853-02 | ABSTRACT The Rural Alaska Community Action Program (RurAL CAP), which administers Head Start schools in rural Alaska, reports that 68% of Alaska Native children ages 3 to 5 years are overweight and 43% are obese. Diet, physical activity, and sleep hygiene are primary risk factors for childhood obesity, a risk factor fo... | Non-SBIR/STTR | 6project_grants_public |
gen_43149b28df6c3455d33bed929067e73b | Improving awareness of women with hypertension: ROAR (Rural, Obese, At Risk) Career Enhancement Core | NIH | AUGUSTA UNIVERSITY | 5U54HL169191-02 | More than 1 in 3 women are living with heart disease and many are unaware of the risks. Hypertension is a major modifiable risk factor for cardiovascular disease (CVD), and ~47% of adults in the US have hypertension. In ~85% of cases, the cause of hypertension is unknown and only ~50% of patients taking medication achi... | Research Centers | 6project_grants_public |
gen_4591cf848fecfb4555b5ce90ed8ca212 | Mechanisms of Telomere Cohesion | NIH | NEW YORK UNIVERSITY SCHOOL OF MEDICINE | 1R35GM149355-01 | Project Summary/Abstract Telomeres, the specialized structures at chromosome ends, are comprised of TTAGGG repeats, telomere repeat containing RNA (TERRA), and the shelterin protein complex. Sister chromatids are held together from the time of their replication in S phase until their separation in mitosis by cohesin ri... | Non-SBIR/STTR | 6project_grants_public |
gen_1466bd22dd47a95f0ef63468efe86890 | Sex determination and the sex-determining locus in aedine mosquitoes | NIH | VIRGINIA POLYTECHNIC INST AND ST UNIV | 5R01AI179056-02 | Abstract Sex is critical to the survival and evolution of sexually reproducing organisms including mosquitoes. A dominant male-determining factor (M factor) is the primary signal that controls sex-determination in mosquitoes. Nix, the M factor in the yellow fever mosquito Aedes aegypti, is the first M factor found in m... | Non-SBIR/STTR | 6project_grants_public |
gen_81a536db755b37f71bb9c5b841f34fde | Identifying the Structural Adaptations that Drive the Mechanically Induced Growth of Skeletal Muscle | NIH | UNIVERSITY OF WISCONSIN-MADISON | 5R01AR082816-02 | Project Summary / Abstract Mechanical signals play a major role in the regulation of skeletal muscle mass, and the maintenance of muscle mass contributes significantly to disease prevention and quality of life. Although the link between mechanical signals and the regulation of muscle mass has been recognized for decade... | Non-SBIR/STTR | 6project_grants_public |
gen_c1578cab1a7fe8244a076a1b1bee63ba | Functional consequences of evolutionary innovation in histone repertoires | NIH | FRED HUTCHINSON CANCER CENTER | 5K99GM149928-02 | PROJECT SUMMARY Histone proteins package DNA into chromatin and regulate all DNA-templated biological processes in eukaryotes. Consistent with their essential function, mutations or misregulation of histones result in many diseases. While core histones primarily function in genome packaging, histone variants can replac... | Other Research-Related | 6project_grants_public |
gen_fd2d14632315590fcfb68ea35ab7e621 | Multi-site Gastrointestinal Cancer Detection by Stool DNA Methylation | NIH | MAYO CLINIC ROCHESTER | 4R37CA214679-06 | PROJECT SUMMARY/ABSTRACT: Gastrointestinal (GI) malignancies lead cancer deaths worldwide, killing ~3 million annually. In the U.S., only colorectal cancers (CRC) are screened. Other GI cancers are not screened due to lack of accurate tests or because prevalence is deemed too low for cost-effective screening. Consequen... | Non-SBIR/STTR | 6project_grants_public |
gen_ee4f459cfdc93d5b4ffb4ed939f04d91 | Determining the Functional Significance of Mutations Observed in Envelope Protein Following Serial In Vivo Passaging of Human-Simian Immunodeficiency Virus | NIH | TEXAS BIOMEDICAL RESEARCH INSTITUTE | 1R03AI174973-01A1 | Abstract/Summary: Commonly used animal models of HIV-1 include infection of macaques with Simian Immunodeficiency Virus (SIV) or Simian-Human Immunodeficiency Virus (SHIV) containing HIV envelope (Env) or reverse transcriptase. These animal models have been extremely useful in understanding HIV pathogenesis and disease... | Non-SBIR/STTR | 6project_grants_public |
gen_d58a697e74101b11fa1e3fbafee6557e | Impact of Obesity on Chemotherapy-Induced Cytotoxicity: Immune Cells and Skeletal Muscle | NIH | UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA | 1K99CA276891-01 | PROJECT SUMMARY / ABSTRACT The number of cancer patients and cancer survivors continues to increase while the prevalence of obesity also continues to increase in the US. Obesity is associated with a greater risk for developing 40% of cancers and two of the four most prevalent cancers (i.e. breast and colon), are tightl... | Other Research-Related | 6project_grants_public |
gen_f270b39454ece620b17b10acaf8fb9ac | OCT-based functional biomarkers for degenerative diseases of the photoreceptor-RPE-choroid neurovascular unit | NIH | UNIVERSITY OF CALIFORNIA AT DAVIS | 5R01EY034340-02 | OCT-based functional biomarkers for degenerative diseases of the photoreceptor-RPE-choroid neurovascular unit Abstract: Important diseases of the photoreceptor-RPE-choroid neurovascular unit include age-related macular degeneration (AMD), retinitis pigmentosa (RP), and other inherited retinal degenerations (IRDs). The ... | Non-SBIR/STTR | 6project_grants_public |
gen_2e4b8a6325c8ced588532d7021e369d5 | Osmotic Regulation of a Peptide Ligand-Mediated Signaling | NIH | RUTGERS THE STATE UNIV OF NJ CAMDEN | 5R35GM151096-02 | Abstract Cells in a multicellular organism constantly communicate by ligand-receptor-mediated signaling to coordinate their growth, development, and adaptation to the environment. The peptide ligands-triggered signaling is the most abundant in this network in humans, dysregulation of which contributes to many prevalen... | Non-SBIR/STTR | 6project_grants_public |
gen_24a45556acf071ffaf44998779d3180e | Safety and efficacy of Belatacept in heart transplantation | NIH | NEW YORK UNIVERSITY SCHOOL OF MEDICINE | 5U01AI174997-02 | Project Summary: Although calcineurin inhibitors (CNIs), including tacrolimus have led to excellent 1-year outcomes in heart transplantation, long-term survival remains limited by cardiac allograft vasculopathy, driven by donor-specific-antibodies (DSA), and by CNI-associated morbidity, dominated by chronic kidney dise... | Non-SBIR/STTR | 6project_grants_public |
gen_e68e887d8f31cc5bb90204841e753068 | Illuminating Lujo virus glycoprotein structure, receptor engagement and neutralizing antibody epitopes | NIH | LA JOLLA INSTITUTE FOR IMMUNOLOGY | 1R21AI180853-01 | Project Summary The Mammarenavirus genus of the Arenavirus family contains multiple zoonotic pathogens with the potential to cause hemorrhagic fever. These include the South American viruses Junin virus (JUNV; Argentinian hemorrhagic fever) and Machupo virus (MACV; Bolivian hemorrhagic fever), and Lassa virus (LASV), w... | Non-SBIR/STTR | 6project_grants_public |
gen_dcfeb30627a1426e2e99e278ec47a2bc | Mechanisms linking the frail sarcomere to noncompaction cardiomyopathy | NIH | NORTHWESTERN UNIVERSITY AT CHICAGO | 5K99HL168239-02 | Project Summary/Abstract The predominant myosin heavy chain expressed in human heart, beta-MyHC, is encoded by the MYH7 gene. MYH7 variants are well described in hypertrophic cardiomyopathy and less frequently seen in dilated cardiomyopathy. A recent series of publications link variants in the 5’ end of the MYH7 gene a... | Other Research-Related | 6project_grants_public |
gen_d79adbe1d804b456013b18415e1b8da8 | Planning & Evaluation | NIH | UNIVERSITY OF CALIFORNIA RIVERSIDE | 5U54CA285114-02 | The goals of the Planning and Evaluation Core (PEC) are to monitor, evaluate, and assess the progress of our U54 Partnerships in meeting its milestones, objectives, and goals. The Core supports our University of California, Riverside (UCR) – City of Hope Comprehensive Cancer Center (CoHCCC) U54 Partnership’s goals of c... | Research Centers | 6project_grants_public |
gen_70596c6ee3d872d2723b89c1cec1d03b | Synthesis of Bioactive Natural Products and Unnatural Congeners | NIH | FLORIDA STATE UNIVERSITY | 5R35GM150795-02 | Project Summary/Abstract Alkaloid natural products have had an immense impact on the field of therapeutic medicine, and hold promise for the discovery of new neuropharmacological treatments. One area of proposed research in the Smith Lab concerns the development of new psychoplastogenic compounds based on the psychede... | Non-SBIR/STTR | 6project_grants_public |
gen_7091e600bc4e516a5fe1dda6de50c976 | Reducing Stigma in People Who Inject Drugs with HIV Using a Rapid Start Antiretroviral Therapy Intervention | NIH | YALE UNIVERSITY | 3R01TW012674-02S1 | HIV transmission continues in low- and middle-income countries (LMIC), especially among key affected populations (KAP) and in settings of high stigma and discrimination. In Malaysia, a LMIC in SE Asia, HIV incidence and mortality is increasing. HIV is concentrated among KAPs, especially people who inject drugs (PWID), ... | Non-SBIR/STTR | 6project_grants_public |
gen_8222ea247a3f176ebc989b6716bde3ed | Effect of weight loss on intermuscular adipose tissue (IMAT) signaling | NIH | UNIVERSITY OF COLORADO DENVER | 3R01DK134706-02S1 | Project Summary/Abstract Black Americans experience disproportionality high rates of obesity, insulin resistance and diabetes and may derive fewer metabolic benefits from weight loss compared to their White counterparts. The mechanisms responsible for these differences are poorly understood as Black men and women are t... | Non-SBIR/STTR | 6project_grants_public |
gen_b0edafb6a3fececbe00700122d67afe2 | Actin regulation by cyclase-associated protein | NIH | EMORY UNIVERSITY | 1R01GM144563-01A1 | Project Summary Reorganization of the actin cytoskeleton supports many dynamic cell biological processes, such as cell migration, cytokinesis, vesicle trafficking, and morphogenesis. Although actin spontaneously polymerizes and depolymerizes by itself, the dynamic properties of actin need to be controlled by actin-regu... | Non-SBIR/STTR | 6project_grants_public |
gen_ffec76512ebcbb1a99d5efdea51d128e | Development of Potent Estrogen Receptor Beta Agonists for Treating Glioblastoma | NIH | UNIVERSITY OF TEXAS HLTH SCIENCE CENTER | 1R01CA269866-01A1 | Glioblastoma (GBM) is the most common primary malignant brain tumor with a survival time of approximately 19 months and the 5-year survival rate is ~10%. Standard treatment for GBM consists of surgical resection, external beam radiation therapy (XRT), and adjuvant chemotherapy with temozolomide; however, resistance to ... | Non-SBIR/STTR | 6project_grants_public |
gen_e775f2347baa82d606714a69f8a157ce | Genetic interactions among targets of master regulator genes as drivers of complex behavior in Drosophila intestinal stem cells | NIH | CALIFORNIA STATE UNIVERSITY NORTHRIDGE | 1R16GM149452-01 | PROJECT SUMMARY Several master regulator (MR) genes have been characterized in tissue stem cells across organs and species. However, they remain poor candidates for therapeutic manipulation because they are highly pleiotropic, affecting hundreds of targets and operating across many organ systems. Therefore, only a bett... | Non-SBIR/STTR | 6project_grants_public |
gen_39a1084edecce6faa687c722dabc4a8d | Leveraging Health Systems to Increase Implementation of Evidence-based Surgical Cancer Care | NIH | UNIVERSITY OF ALABAMA AT BIRMINGHAM | 5K08CA283001-02 | PROJECT SUMMARY Hospitals are increasingly consolidating into health systems with shared ownership and management. Care in a health system has potential benefits for surgical cancer patients including improved access, care coordination, and strategies to disseminate and implement a rapidly evolving evidence-base into p... | Other Research-Related | 6project_grants_public |
gen_db62ac329e9c9183324b0d4585b7662d | High-throughput, purification-free, and ultrasensitive transmembrane nanosensor arrays for digital counting of microRNA biomarkers of intact exosomes | NIH | ARIZONA STATE UNIVERSITY-TEMPE CAMPUS | 5R61CA278558-02 | Project Summary/Abstract Rapid and specific histopathologic diagnoses are critical for cancer treatment. Tumor tissue biopsy is routinely performed to detect and monitor cancer progression. Current test biopsies require surgically-collected tissue samples from detectable primary or metastatic tumors. Several difficulti... | Non-SBIR/STTR | 6project_grants_public |
gen_d1487f6876d85b7ac11c6cb4d866794f | Development of novel malaria pre-erythrocytic vaccine antigens targeting Plasmodium sporozoite liver infection | NIH | MERCER UNIVERSITY MACON | 5R21AI166451-03 | Previously, using a phage peptide display library, our group has identified Plasmodium parasite ligands and corresponding host cell receptors important for sporozoite-Kupffer cell interaction in the mammalian liver. Using a similar approach, we identified the HP1 peptide, a structural mimic of a ligand that the sporozo... | Non-SBIR/STTR | 6project_grants_public |
gen_9a3c2b22857cadfcf08478557d371e5d | Sorting and characterization of mechanically heterogeneous cell populations based on cellular contractility | NIH | UNIVERSITY OF ARKANSAS AT FAYETTEVILLE | 1R21EB034930-01 | Project Summary Cellular contractility plays a critical role in both development and disease. Recent evidence suggests that even within a cell population derived from the same source, vast heterogeneity exists in terms of cellular contractility. Dysregulation of spatiotemporally organized cellular contractility often r... | Non-SBIR/STTR | 6project_grants_public |
gen_229b73c8a244e4a134bf894e9663619e | Mechanotransduction via LIM Domain Protein Mechanosensing | NIH | LOYOLA UNIVERSITY CHICAGO | 5R01GM148644-02 | Project Summary Mechanical interactions play a fundamental role in physiology, allowing cells to move, generate forces, and assemble into multicellular structures. Key to these processes is the ability of cells to turn mechanical signals into biochemical signals, an activity known as mechanotransduction. The search for... | Non-SBIR/STTR | 6project_grants_public |
gen_82663bbb4d9a3d0fef1f374482bb75ab | Explant human skin perfusion model to study mechanisms of chemical injury and mitigation | NIH | UNIVERSITY OF PITTSBURGH AT PITTSBURGH | 1R34AR083572-01 | The changing geopolitical environment has increased the risk of mass population exposure to chemical vesicants-induced skin injuries from a large-scale incident improvised by a state or terrorist organization executed act but there are few countermeasures available having limited efficacy. The long-term goal is to deve... | Non-SBIR/STTR | 6project_grants_public |
gen_735b54f3ec7b01bb704160d10b2f4c7e | LEAarning analytics and AI for personaliseD lEaRning | European Commission (EC) | VIRTUALCARE, LDA;Πανεπιστήμιο Κρήτης – Τμήμα Βιολογίας;CENTRE FOR ADVANCEMENT OF RESEARCH AND DEVELOPMENT IN EDUCATIONAL TECHNOLOGY LTD-CARDET;EDEX - EDUCATIONAL EXCELLENCE CORPORATION LIMITED;Tallinn University;University of Pitesti | Not available | Unknown | 6project_grants_public |
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