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gen_f9217c0fe3603563b35f3d76872ffed5 | Metallisation of Textiles to make Urban living for Older people more Independent Fashionable | European Commission | UNIWERSYTET PRZYRODNICZO-HUMANISTYCZNY W SIEDLCACH | CORDIS-760789 | Urban areas are seeing an increasing population of older people and existing approaches to care for them are becoming unsustainable creating a European wide societal challenge. Assistive technology can provide them with security that will enable them to live independently e.g. wearing alarms and tracking devices around... | H2020-EU.2.1.3. / 2.1.3 LEIT - Advanced materials | 0business_rnd_innovation |
gen_83391d474fc154f999fd592992d3ae75 | Innovative materials and techniques for the conservation of 20th century concrete-based cultural heritage | European Commission | FUNDACIÓN EDUARDO CHILLIDA Y PILAR BELZUNCE | CORDIS-760858 | InnovaConcrete is an innovative and ambitious proposal that aims at preserving concrete-based monuments, the most significant tangible Cultural Heritage (CH) in the 20th Century. To achieve this goal, we have recruited an interdisciplinary team presenting a strong scientific background in simulation techniques and nano... | H2020-EU.2.1.2. / 2.1.2 LEIT - Nanotechnologies | 0business_rnd_innovation |
gen_c8d564ef33ea3c1e38997f7ffce3bae4 | High performance MOF and IPOSS enhanced membrane systems as next generation CO2 capture technologies | European Commission | Nederlandse Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek TNO | CORDIS-760899 | Atmospheric warming due to greenhouse gases has become a serious global concern. The shifting from fossil fuel to renewable energy has been slow mostly due to technological barriers. Meanwhile, the demand for energy is growing rapidly which makes fossil fuel consumptions inevitable, in spite of their high emission of G... | H2020-EU.2.1.2. / 2.1.2 LEIT - Nanotechnologies | 0business_rnd_innovation |
gen_7ab55323ef037bf2906f9d2f899d6d15 | BIOtechnological processes based on microbial platforms for the CONversion of CO2 from ironsteel industry into commodities for chemicals and plastics | European Commission | ARKEMA FRANCE | CORDIS-761042 | The main objective of BIOCON-CO2 is to develop and validate in industrially relevant environment a flexible platform to biologically transform CO2 into added-value chemicals and plastics. The versatility and flexibility of the platform, based on 3 main stages (CO2 solubilization, bioprocess and downstream) will be prov... | H2020-EU.2.1.4. / 2.1.4 LEIT - Biotechnology | 0business_rnd_innovation |
gen_5b8d1a6cf478e8b5218efbb72e2cbd30 | Development and Validation of an Innovative Solar Compact Selective-Water-Sorbent-Based Heating System | European Commission | INNOHEAT SWEDEN AB | CORDIS-764025 | The SWS-HEATING project will develop an innovative seasonal thermal energy storage (STES) unit with a novel storage material and creative configuration, i.e. a sorbent material embedded in a compact multi-modular sorption STES unit. This will allow to store and shift the harvested solar energy available abundantly duri... | H2020-EU.3.3. / 3.3 Societal Challenges - Energy | 6project_grants_public |
gen_7d7703d8081cd739ecd5c00de6e56ebc | S100A9-dependent radiation resistance in brain metastasis | Worldwide Cancer Research | Spanish National Cancer Research Centre | HRCS22_14537 | With the advent of improved diagnosis and novel therapeutic approaches cancer patients live longer with systemic disease. However this increased survival is paradoxically associated with a growing incidence of brain relapses. Brain metastasis remains an unmet clinical need with limited therapeutic possibilities. Among ... | 5.1 Pharmaceuticals | 6project_grants_public |
gen_d44bb0eeec670b5039b1042c16dfeef5 | Analysis of the mitochondrial dysfunction in FXN deficient neurons to generate a drug screening test | Ataxia UK | Spanish National Research Council | HRCS22_12153 | The main genetic cause of Friedreich’s ataxia (FA) is a GAA triplet expansion within the first intron of the frataxin (fxn) gene. More than 30 repetitions are considered pathogenic, and most FA patients have 600-900 repeats. Most FA animal models show very mild phenotype, likely due to the difficulty in recreating the ... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_62424f2de2c971ed82f795fb8d72e0ad | Intelligent management system for integrated multi-trophic aquaculture | European Commission | CAMLI YEM BESICILIK SANAYI VE TICARET ANONIM SIRKETI | CORDIS-774109 | The Integrated Multi-Trophic Aquaculture (IMTA) is acknowledged as a promising solution for the sustainable development of aquaculture. However, IMTA has been only tested at very small scale in Europe, while management of large-scale IMTA areas remains difficult. The high level ambition of Impaqt project is to drive a ... | H2020-EU.3.2. / 3.2 Societal Challenges - Food | 6project_grants_public |
gen_d03fc8f099385123ef1bf97e2dcc384d | PHUSICOS: 'According to nature' - solutions to reduce risk in mountain landscapes | European Commission | RISQUES ET DEVELOPPEMENT | CORDIS-776681 | PHUSICOS, meaning 'According to nature' in Greek, demonstrates how nature-based solutions (NBSs) provide robust, sustainable and cost-effective measures for reducing the risk of extreme weather events in rural mountain landscapes. Although mountains amplify risks, and even more so under extreme weather events, mountain... | H2020-EU.3.5. / 3.5 Societal Challenges - Climate | 6project_grants_public |
gen_ad24423bae78114aa696c416f722f7f2 | Programmable Systems for Intelligence in Automobiles | European Commission | DAT.MOBILITY BV; Graz University of Technology; IDIADA, Automotive Technology | CORDIS-783190 | The ambition of PRYSTINE is to strengthen and to extend traditional core competencies of the European industry, research and universities in smart mobility and in particular the electronic component and systems and cyber-physical systems domains. PRYSTINE's target is to realize Fail-operational Urban Surround perceptIO... | H2020-EU.2.1.1. / 2.1.1 LEIT - ICT | 0business_rnd_innovation |
gen_3a243f1925017ed37a8ee2456ef50e85 | Legislative Assessment for Safety Hazards of Fire and Innovations in Ro-ro ship Environment | European Commission | UNIFIRE AKTIEBOLAG | CORDIS-814975 | Ro-ro ships are an important component of the global transportation system, but an increasing trend of ro-ro ship fires in recent years call for improved fire protection. From comprehensive ship operators’ experience and by participation in ongoing work for the European Maritime Safety Agency and the International Mari... | H2020-EU.3.4. / 3.4 Societal Challenges - Transport | 6project_grants_public |
gen_79d051239d1d97991d8d9ae3d88272c4 | Behavioural, Ecological and Socio-economic Tools for Modelling Agricultural Policy | European Commission | UNITED KINGDOM RESEARCH AND INNOVATION | CORDIS-817501 | Nearly 50% of the European Union (EU) land area is agricultural. However, the ecosystem services (ESS) provided by these agro-ecosystems – including food, bioenergy, water, carbon storage and biodiversity – are threatened by processes such as land-use intensification and changing climate. European, national and regiona... | H2020-EU.3.2. / 3.2 Societal Challenges - Food | 6project_grants_public |
gen_f1f43f25093e52bd472ff8366209e959 | Tropical and South Atlantic climate-based marine ecosystem predictions for sustainable management | European Commission | INSTITUT SENEGALAIS DE RECHERCHES AGRICOLES; Centre national de la recherche scientifique; Universidad Complutense de Madrid | CORDIS-817578 | Sustainable management of human activities affecting Atlantic marine ecosystems is critical to maintain its health and to support the blue economy of the bordering countries. TRIATLAS will contribute to this by delivering knowledge of the current state and future changes of the Atlantic marine ecosystems. We achieve th... | H2020-EU.3.2. / 3.2 Societal Challenges - Food | 6project_grants_public |
gen_efa9e63dc84ee846ab4db4753e35fd20 | Non-Thermal physical technologies to preserve healthiness of fresh and minimally processed fruit and vegetables | European Commission | HUERTA DE PERALTA | CORDIS-817936 | SHEALTHY proposal aims to assess and develop an optimal combination of non-thermal sanitization, preservation and stabilization methods to improve the safety (inactivation of pathogens and spoilage microorganisms), while preserving the nutritional quality (up to 30%) and prolonging the shelf-life (up to 50%) of minimal... | H2020-EU.3.2. / 3.2 Societal Challenges - Food | 6project_grants_public |
gen_c61319a70b5f2dda41d10b124ff5d3a7 | Bringing down costs of BIPV multifunctional solutions and processes along the value chain, enabling widespread nZEBs implementation | European Commission | University of Applied Sciences and Arts of Southern Switzerland | CORDIS-817991 | Building-integrated photovoltaic (BIPV) technology has the potential to significantly contribute to the achievement of the demanding energy efficiency targets set by the EU, however, its market uptake has been hindered in the past years by the difficulties of the industry in providing holistic solutions complying with ... | H2020-EU.3.3. / 3.3 Societal Challenges - Energy | 6project_grants_public |
gen_3d2c983481eb6cebe619dc687ae9182a | Quantum Internet Alliance | European Commission | SURFSARA BV; University of Geneva; SWABIAN INSTRUMENTS GMBH; University of Copenhagen | CORDIS-820445 | The future Quantum Internet will provide radically new internet applications by enabling quantum communication between any two points on Earth. The Quantum Internet Alliance (QIA) targets a Blueprint for a pan-European Quantum Internet by ground-breaking technological advances, culminating in the first experimental dem... | H2020-EU.1.2. / 1.2 Future and Emerging Technologies (FET) | 6project_grants_public |
gen_df769c698e795cf4e3a3313bdfb4d7eb | New Technologies, Tools and Strategies for a Sustainable, Resilient and Innovative European Aquaculture | European Commission | Veterinaerinstituttet | CORDIS-862658 | The vision of the EU aquaculture industry is to grow substantially in the next decade and to provide annually 4.5 million tons of sustainable food products. To this aim, NewTechAqua intends to expand and diversify EU production of finfish, molluscs and microalgae by developing and validating technologically-advanced, r... | H2020-EU.3.2. / 3.2 Societal Challenges - Food | 6project_grants_public |
gen_128dec60943d18952961ecc258fcfac2 | MICROALGAE PROTEIN INGREDIENTS FOR THE FOOD AND FEED OF THE FUTURE | European Commission | APEXAGRI SAS | CORDIS-862980 | ProFuture will set the basis for market uptake of innovative, healthy and sustainable food and feed products, reformulated with protein-rich ingredients from Spirulina, Lemon/lightly/Chlorella vulgaris, Tetraselmis chuii and Nannochloropsis oceanica. Multi-factors approach and LCA/LCC will boost sustainability of the m... | H2020-EU.3.2. / 3.2 Societal Challenges - Food | 6project_grants_public |
gen_06a7a16050162602eea86d3a3fcb4425 | All Atlantic Ocean Sustainable, Profitable and Resilient Aquaculture | European Commission | COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCH; University of Cape Town | CORDIS-863034 | ASTRAL will develop new, sustainable, profitable and resilient value chains for integrated multi-trophic aquaculture (IMTA) production within the framework of existing, emerging and potential Atlantic markets. The proposal gathers four IMTA labs including open offshore (Ireland, Scotland), flow-through inshore (South A... | H2020-EU.3.2. / 3.2 Societal Challenges - Food | 6project_grants_public |
gen_29097fc8af03406c52cdc80a8f975c2a | Securing biodiversity, functional integrity and ecosystem services in DRYing rivER networks | European Commission | Nanjing Institute of Geography and Limnology Chinese Academy of Sciences | CORDIS-869226 | River networks are among Earth’s most threatened hot-spots of biodiversity and provide key ecosystem services (e.g. supply drinking water and food, climate regulation) essential to sustaining human well-being. Climate change and increased human water use are causing more rivers and streams to dry, with devastating impa... | H2020-EU.3.5. / 3.5 Societal Challenges - Climate | 6project_grants_public |
gen_a43375304c6646a993a95be7bc0e96b1 | Full-value chain Optimised Climate User-centric Services for Southern Africa: FOCUS-Africa | European Commission | University of the Witwatersrand | CORDIS-869575 | The central objective of FOCUS-Africa is to develop sustainable tailored climate services in the Southern African Development Community (SADC) region for four sectors: agriculture and food security, water, energy and infrastructure. The proposed co-production amongst end-users, climate scientists and sectoral service p... | H2020-EU.3.5. / 3.5 Societal Challenges - Climate | 6project_grants_public |
gen_0c41c8b3471d8083b666763eb1415179 | Evaluation, control and Mitigation of the EnviRonmental impacts of shippinG Emissions | European Commission | ARISTOTELIO PANEPISTIMIO THESSALONIKIS | CORDIS-874990 | The objectives of EMERGE are (i) to quantify and evaluate the effects of potential emission reduction solutions for shipping in Europe for several scenarios, and (ii) to develop effective strategies and measures to reduce the environmental impacts of shipping. EMERGE objectives will be achieved through real-world test ... | H2020-EU.3.4. / 3.4 Societal Challenges - Transport | 6project_grants_public |
gen_d69dffa1dd0d98448682a573eae8353f | Unveiling mechanisms of tumor formation linked to BRCA2 mutation | Worldwide Cancer Research | Spanish National Research Council | HRCS22_14389 | Inactivating germline mutations affecting a single copy of BRCA2 are associated with an increased risk of breast and ovarian cancer. However, what drives tumorigenesis in carriers of heterozygous BRCA2 mutations remains elusive. Moreover, BRCA2 deficient breast tumors lack a clear pathological phenotype that distinguis... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_15829c19ae0b8ae0b3610e5c054f32b2 | Transforming Weather Water data into value-added Information services for sustainable Growth in Africa | European Commission | STRATHMORE UNIVERSITY; FUTUREWATER SL | CORDIS-776691 | Objectives: Provide currently unavailable geo-information on weather, water and climate for sub-Saharan Africa by enhancing satellite-based geo-data with innovative in situ sensors and developing related information services that answer needs of African stakeholders and the GEOSS community. Concept: A systematic feedba... | H2020-EU.3.5. / 3.5 Societal Challenges - Climate | 6project_grants_public |
gen_af78ca09177d671f06adf6483f1c106f | NextPerception - Next generation smart perception sensors and distributed intelligence for proactive human monitoring in health, wellbeing, and automotive systems | European Commission | Imec; COMmeto; Brno University of Technology | CORDIS-876487 | We put our lives increasingly in the hands of smart complex systems making decisions that directly affect our health and wellbeing. This is very evident in healthcare - where systems watch over your health - as well as in traffic - where autonomous driving solutions are gradually taking over control of the car. The acc... | H2020-EU.2.1.1. / 2.1.1 LEIT - ICT | 6project_grants_public |
gen_4dac3f797f4857a1523f08b9af20442b | A Cognitive Fractal and Secure EDGE based on an unique Open-Safe-Reliable-Low Power Hardware Platform Node | European Commission | IKERLAN S. COOP; RO TECHNOLOGY SRL; CAF SIGNALLING S.L | CORDIS-877056 | The objective of this research activity is to create a reliable computing node that will create a Cognitive Edge under industry standards. This computing node will be the building block of scalable Internet of Things (from Low Computing to High Computing Edge Nodes). The cognitive skill will be given by an internal and... | H2020-EU.2.1.1. / 2.1.1 LEIT - ICT | 6project_grants_public |
gen_6926f22ba3d0b8c0b62d3e4d2a1d1d85 | Graphene Flagship Core Project 3 | European Commission | University of Warwick; MICRO RESIST TECHNOLOGY GESELLSCHAFT FUER CHEMISCHE MATERIALIEN SPEZIELLER PHOTORESISTSYSTEME MBH; Université de Strasbourg; Technion - Israel Institute of Technology; MEDICA S.P.A.; Thales; ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE; SIEC BADAWCZA LUKASIEWICZ ... | CORDIS-881603 | This proposal describes the third core project of the Graphene Flagship. It forms the fourth phase of the FET flagship and is characterized by a continued transition towards higher technology readiness levels, without jeopardizing our strong commitment to fundamental research. Compared to the second core project, this ... | H2020-EU.1.2. / 1.2 Future and Emerging Technologies (FET) | 6project_grants_public |
gen_65db645888dfccb645eea01317ca38a2 | Edge enabled Privacy and Security Platform for Multi Modal Transport | European Commission | UNITED TECHNOLOGIES RESEARCH CENTRE IRELAND, LIMITED | CORDIS-883135 | E-CORRIDOR aims at providing a flexible, secure and privacy aware framework allowing confidential, distributed and edge enabled security services, as threat analysis and prevention as well as privacy aware seamless access mechanism in multi-modal transport systems. Cyber attacks influence is growing in our everyday lif... | H2020-EU.3.7. / 3.7 Societal Challenges - Secure societies | 6project_grants_public |
gen_05e95ff35395270c84d2c01b72622e75 | Application of Solar Thermal Energy to Processes | European Commission | ARCELORMITTAL TUBULAR PRODUCTS IASI SA; PRODUCTION TRADE AND SUPPORT OF MACHINABLE PRODUCTS OF SOFTWARE AND INFORMATICS - RELATIONAL TECHNOLOGY AE | CORDIS-884411 | Application of Solar Thermal Energy to Processes (ASTEP) will create a new innovative Solar Heating for Industrial Processes (SHIP) concept focused on overcoming the current limitations of these systems. This solution is based on modular and flexible integration of two innovative designs for the solar collector (SunDia... | H2020-EU.3.3. / 3.3 Societal Challenges - Energy | 6project_grants_public |
gen_0d74d6b5ae079281a0c02748c2846081 | Development of innovative biotic symbiosis for plastic biodegradation and synthesis to solve their end of life challenges in the agriculture and food industries | European Commission | University of Almería; NATURPLAS PLASTICOS AGRICOLAS SL | CORDIS-887648 | RECOVER is a disruptive RIA proposal built upon the actual needs to solve the contamination of agro-fields with non-biodegradable agro-plastics as well as to improve municipal waste handling by decreasing drastically the packaging fraction going to unsustainable waste management routes. We intend to reach our ambitiou... | H2020-EU.2.1.4. / 2.1.4 LEIT - Biotechnology | 6project_grants_public |
gen_e43cfb8632c62b0d7a00b3001283944f | Flexible Superheated Steam Torrefaction and Grinding of Indigenous Biomass from Remote Rural Sources to Produce Stable Densified Feedstocks for Chemical and Energy Applications | European Commission | URBION CONSULTORES SL | CORDIS-636865 | The objective of SteamBio is to demonstrate a mobile processing concept that will enable efficient pre-treatment of agro-forestry residues for use as flexible feedstocks in chemical and process industries. These ligno-cellulosic materials originated from rural locations will be upgraded and densified into uniform sizes... | H2020-EU.2.1.5. / 2.1.5 LEIT - Advanced manufacturing and processing | 0business_rnd_innovation |
gen_e670688996df7c0ae87eb6f55759dff3 | Towards effective radiation protection based on improved scientific evidence and social considerations - focus on radon and NORM | European Commission | EUROPEAN ORGANISATION FOR RESEARCH AND TREATMENT OF CANCER AISBL | CORDIS-900009 | RadoNorm is designed to initiate and perform research and technical development in support of European Union Member States, Associated Countries and the European Commission in their efforts to implement the European radiation protection Basic Safety Standards. The proposed multidisciplinary and inclusive research proje... | H2020-Euratom / Euratom | 6project_grants_public |
gen_141eaaa6f790e6d2e38a5f1c5b9d0e8c | PRE-DISposal management of radioactive waste | European Commission | UJV REZ, a. s.; Amphos 21 Consulting; BUNDESANSTALT FUER MATERIALFORSCHUNG UND -PRUEFUNG | CORDIS-945098 | The PREDIS project targets the development and implementation of activities for pre-disposal treatment of radioactive waste streams other than nuclear fuel and high-level radioactive waste. Member States will profit from measurable benefits including the further development and increase in Technological Readiness Level... | H2020-Euratom / Euratom | 6project_grants_public |
gen_517ca4f6570cef5a09bff87254f46cca | AIRFRAME ITD | European Commission | Fundacion para la Investigacion, Desarrollo y Aplicacion de Materiales Compuestos; AIRBUS HELICOPTERS DEUTSCHLAND GMBH; Airbus Operations Limited; CORIOLIS COMPOSITES; Delft University of Technology; University of Nottingham; FOKKER AEROSTRUCTURES BV | CORDIS-945521 | The Airframe ITD aims at re-thinking and developing the technologies as building blocks and the “solution space” on the level of the entire or holistic aircraft: pushing aerodynamics across new frontiers, combining and integrating new materials and structural techniques – and integrating innovative new controls and pro... | H2020-EU.3.4. / 3.4 Societal Challenges - Transport | 6project_grants_public |
gen_9b817405755b4c1e6f62070e897fcb9c | Functional and advanced insulating and energy harvesting/storage materials across climate adaptive building envelopes | European Commission | BIOG3D MONOPROSOPI IKE | CORDIS-952886 | Buildings account for around 40% of total energy use and 36% of CO2 emissions in Europe . According to the recast Directive on the energy performance of buildings (EPBD) all new buildings after 2020 should reach nearly zero energy levels, meaning that they should demonstrate very low energy needs mainly covered by rene... | H2020-EU.2.1.3. / 2.1.3 LEIT - Advanced materials | 6project_grants_public |
gen_f9d70752e5b4f9fea23f20e034eae02f | DISRUPTIVE KESTERITES-BASED THIN FILM TECHNOLOGIES CUSTOMISED FOR CHALLENGING ARCHITECTURAL AND ACTIVE URBAN FURNITURE APPLICATIONS | European Commission | IMRA EUROPE SAS | CORDIS-952982 | CUSTOM-ART aims at developing the next generation of building and product integrated photovoltaic modules (BIPV and PIVP respectively), based on earth-abundant and fully sustainable thin film technologies. Nowadays, BIPV and PIPV are identified as key enabling technologies to make “near Zero Energy Buildings” and “net ... | H2020-EU.2.1.3. / 2.1.3 LEIT - Advanced materials | 0business_rnd_innovation |
gen_ba711333abe514154cc47f0bd217af7d | nexT gEneRation sMart INterconnectEd ioT | European Commission | ALTERUNA AB | CORDIS-957406 | The vision of TERMINET is to provide a novel next generation reference architecture based on cutting-edge technologies such as SDN, multiple-access edge computing, and virtualisation for next generation IoT, while introducing new, intelligent IoT devices for low-latency, market-oriented use cases. TERMINET’s primary in... | H2020-EU.2.1.1. / 2.1.1 LEIT - ICT | 0business_rnd_innovation |
gen_419388cbe23fc2d91a0602ad34a816cb | Life-cycle optimization of industrial energy efficiency by a distributed control and decision-making automation platform | European Commission | KASTAMONU ENTEGRE AGAC SANAYI VE TICARET ANONIM SIRKETI; KU Leuven; ACT OPERATIONS RESEARCH IT SRL | CORDIS-958410 | Improving industrial energy efficiency at European Manufacturing level requires the integration of energy data with advanced optimization techniques to guide a company decision making. E2COMATION intends to address the optimization of energy usage, at multiple hierarchical layers of a manufacturing process as well as ... | H2020-EU.2.1.5. / 2.1.5 LEIT - Advanced manufacturing and processing | 0business_rnd_innovation |
gen_de11f55be1c8cb9a178d25b9a423671c | High-pErformance moduLar battery packs for sustaInable urban electrOmobility Services | European Commission | VESTEL ELEKTRONIK SANAYI VE TICARET ANONIM SIRKETI | CORDIS-963646 | The HELIOS project aims at developing and integrating innovative materials, designs, technologies and processes to create a new concept of smart, modular and scalable battery pack for a wide range of electric vehicles used in urban electromobility services, from mid-size electric vehicles to electric buses, with improv... | H2020-EU.3.4. / 3.4 Societal Challenges - Transport | 6project_grants_public |
gen_06e024522e4d1554c59947992cb4cb3d | Heparan Sulfate in Prostate Cancer | NIH | UNIVERSITY OF SOUTH FLORIDA | 3U01CA225784-05S1 | PROJECT SUMMARY - U01CA225784 Prostate cancer (PCa) is one of the most prevalent forms of malignancy and the second most common cause of cancer-related death in men. Uncovering novel mechanisms that control prostatic tumorigenesis may advance development of more effective therapeutics to treat this life-threatening dis... | Non-SBIR/STTR | 6project_grants_public |
gen_2ac43384454add6456fed76d934e2fe2 | Regulation of chemokine receptor signaling | NIH | MEDICAL COLLEGE OF WISCONSIN | 3R35GM149253-02S1 | PROJECT SUMMARY G protein-coupled receptor (GPCR) signaling plays an essential role in many physiological processes and is also involved in many human diseases, yet the mechanisms governing GPCR signaling remain poorly understood. The goal of the proposed research is to further our mechanistic understanding of GPCR sig... | Non-SBIR/STTR | 6project_grants_public |
gen_6c0e33bcc040b10e5989e621daa880ac | Genome-wide Mapping of Ribosome Occupancies with Inhibitor-Induced mRNA Covalent Labeling | NIH | HARVARD UNIVERSITY | 5R21GM148899-02 | Title: Genome-wide Mapping of Ribosome Occupancies with Inhibitor-Induced mRNA Covalent Labeling Ribosome profiling is a powerful method to study translation through genome-wide mapping of translating ribosomes. This breakthrough technology has illuminated many facets of protein synthesis, such as ribosomal pausing, a... | Non-SBIR/STTR | 6project_grants_public |
gen_c20a24c800562bb05511f68c2419a77c | The Impact of Disrupting Sensory Innervation on Tibial Bone Mass | NIH | UNIVERSITY OF NEW ENGLAND | 5R16GM150784-02 | PROJECT SUMMARY Tibia and fibula fractures account for 10% of annual osteoporotic fractures leading to significant morbidity with a 10% mortality rate within 12 months of fracture. Low bone mineral density can dramatically increase fracture risk resulting from a decrease in bone formation by the osteoblast, an increase... | Non-SBIR/STTR | 6project_grants_public |
gen_dfa889af70f584c1571c572a5dbb6612 | Developmental regulation of epithelial polarization by pre-mRNA splicing | NIH | DUKE UNIVERSITY | 1R01DK132120-01A1 | Abstract The apical membrane of epithelial cells in the intestine play critical roles in physiology and homeostasis. Many specialized functions of intestinal epithelial cells, such as nutrient absorption, depend on faithfully sorting proteins to the apical membrane during biosynthetic delivery. However, the cellular me... | Non-SBIR/STTR | 6project_grants_public |
gen_dbe2eb459cc267bff35562e904802b3a | T Cell-Specific BRCA1 Function in Antitumor Immunity and Immunotherapy | NIH | GEORGE WASHINGTON UNIVERSITY | 1R01CA282303-01 | ABSTRACT Women with germline mutations of BRCA1 have about an 80% lifetime risk of developing breast cancer. All somatic cells in a germline BRCA1 mutation carrier harbor the same mutant copy of the BRCA1 gene, yet BRCA1 research is almost exclusively focused on BRCA1’s role in repair of double-strand DNA breaks in th... | Non-SBIR/STTR | 6project_grants_public |
gen_b0e1eec4465b0bd63aa2d044b47a143d | Impacts of Social Determinants of Health and COVID-19 Pandemic Factors on Suicide Risk among Youth | NIH | APPALACHIAN STATE UNIVERSITY | 5R16GM149432-02 | Project Summary Suicide is a significant public health problem among youth. Data indicate suicidal behaviors were increasing among youth even before the COVID-19 pandemic began and have likely increased even more since its onset. This R16 proposed research seeks to address the urgent mental health crisis and respond to... | Non-SBIR/STTR | 6project_grants_public |
gen_a19c0347e10ec8a89446e4f51e048dbf | Impact of inflammatory lipids on Yersinia pestis infection | NIH | UNIVERSITY OF LOUISVILLE | 5R01AI178106-02 | ABSTRACT Yersinia pestis causes the acute human disease commonly referred to as plague. A hallmark manifestation of this disease is delayed inflammation despite active bacterial replication. Y. pestis modulates inflammation by actively inhibiting the expression of pro-inflammatory cytokines via the action of a group o... | Non-SBIR/STTR | 6project_grants_public |
gen_97f6b5c90a2800a9833d8b2ded813619 | Host DNA repair pathways in human cytomegalovirus replication | NIH | UNIVERSITY OF ARIZONA | 1R01AI177392-01 | Human Cytomegalovirus (HCMV) is a double-stranded DNA virus that establishes life-long infection in the human host. The overarching objective of our work is to define critical virus-host interactions important for virus replication and latency, which provide targets for antiviral strategies aimed at limiting viral path... | Non-SBIR/STTR | 6project_grants_public |
gen_8c71b686768008f436679c5809b5ec7c | Computational and theoretical understanding of regulatory mechanisms shaping natural vision | NIH | COLUMBIA UNIVERSITY HEALTH SCIENCES | 5K99EY035357-02 | Project Summary/Abstract How is our visual system capable of making sense out of the complex pattern of light received in the retina? Machine vision has recently been successful at solving complex tasks on natural images such as object classification. Thus, we can use these models to infer computations which transform ... | Other Research-Related | 6project_grants_public |
gen_9af6d5db153678c931fe053a3904d83e | The Hospital to Home Study: A Pragmatic Trial to Optimize Transitions and Address Disparities in Asthma Care | NIH | CHILDREN'S RESEARCH INSTITUTE | 1R01HL161665-01A1 | Despite evidence-based NIH guidelines for asthma, overall morbidity among children has not significantly decreased. In the US, asthma accounts for >150,000 hospitalizations, >600,000 emergency department visits, and nearly 14 million missed school days annually. Striking socioeconomic and racial inequities persist with... | Non-SBIR/STTR | 6project_grants_public |
gen_250241970d052e3905dfa6ec53ffe250 | Health Disparities in Utilization, Quality, and Outcomes for Three Common Ocular Conditions (HealthDOC) | NIH | NORTHWESTERN UNIVERSITY AT CHICAGO | 5R01EY034444-02 | Project Summary/Abstract: Multiple that minority CHIP of The understood. ophthalmology retinopathy. past studies provide strong evidence that disparities exist in healthcare, i ncluding in ophthalmology, and social determinant of health (SDH) play an important role for explaining differences in ethnic and racial recei... | Non-SBIR/STTR | 6project_grants_public |
gen_8fb71daafb1fb8e0b7b3cde6fc8a8721 | Integrated blood and radiomic subtyping to guide immunotherapy treatment selection and early response assessment in metastatic non-small cell lung cancer | NIH | UNIVERSITY OF TX MD ANDERSON CAN CTR | 1R01CA276178-01A1 | ABSTRACT Immune checkpoint inhibitors (ICIs) have improved outcomes in metastatic non-small cell lung cancer (NSCLC), and providers may now choose between multiple first-line ICI-based regimens including ICI monotherapy and ICI with chemotherapy. However, this increase in options has complicated clinical management, wi... | Non-SBIR/STTR | 6project_grants_public |
gen_33fda5caea88a8ef132ae2dcb37b9f26 | Methods for inferring and analyzing gene regulatory networks using single-cell multiomics and spatial genomics data | NIH | COLUMBIA UNIVERSITY HEALTH SCIENCES | 1R35GM150887-01 | Project Summary/Abstract The study of gene regulation provides fundamental mechanistic knowledge to decipher the development of com- plex biological systems and design treatment strategies for diseases by manipulating cell states. Development of single-cell multimodal and multiomics sequencing technologies allows for p... | Non-SBIR/STTR | 6project_grants_public |
gen_b5747b3c89cf740064bbbf4c763a70c4 | Single cell quantification of translation control in early mouse development | NIH | UNIVERSITY OF TEXAS AT AUSTIN | 1R35GM150667-01 | The initial stages of vertebrate embryo development proceed in the absence of transcription. Consequently, protein abundance of preimplantation embryos is regulated by post-transcriptional gene expression programs. In particular, new protein synthesis is required for productive embryogenesis as inhibition of translatio... | Non-SBIR/STTR | 6project_grants_public |
gen_3d196f2a3154459a1beddce73fb50795 | Developing Machine Learning Models for Decision Support and Allocation Optimization in Heart Transplantation | NIH | MEDICAL UNIVERSITY OF SOUTH CAROLINA | 1R01HL162882-01A1 | PROJECT SUMMARY/ABSTRACT The impact of heart transplantation (HTx) remains limited by donor shortages, with an estimated 250,000 adults who may benefit from transplant despite only 3,500 being performed each year in the US. Unfortunately, donor discard rates remain high at 70-80%, with substantial unexplained variabili... | Non-SBIR/STTR | 6project_grants_public |
gen_e7015a0121609291fe173fe3a7d6107f | Mechanisms of tamoxifen-associated endometrial cancer risk | NIH | UNIVERSITY OF UTAH | 5R21CA270580-02 | PROJECT SUMMARY Tamoxifen is the most prescribed cancer drug in the world. Tamoxifen is a selective estrogen receptor modulator (SERM) that is used to treat patients with breast tumors that express estrogen receptor alpha (ER), acting as a partial antagonist that blocks ER’s growth-promoting activity. The use of tamoxi... | Non-SBIR/STTR | 6project_grants_public |
gen_d31fff97ed6d75649169cd5e49b334b5 | Methods for Enantioselective Spirocycle Synthesis and Radical Hydroamination of Trisubstituted Alkenes | NIH | CALIFORNIA INSTITUTE OF TECHNOLOGY | 1K99GM152819-01 | Project Summary/Abstract This proposal focuses on the synergy of experiments and computations in (1) understanding fundamental reactivity in organic and organometallic transformations and (2) enabling reaction design for the discovery of methods for enantioselective spirocycle synthesis and radical hydroamination of t... | Other Research-Related | 6project_grants_public |
gen_ea67c62eb8f93002dace73be4eae065e | Cadherin regulation of planar polarity | NIH | PENNSYLVANIA STATE UNIV HERSHEY MED CTR | 5R35GM150921-02 | PROJECT SUMMARY During human development, cells interact with one another to drive collective and oriented cell behaviors that control organ formation and tissue patterning. This coordination between neighboring cells is governed by planar cell polarity (PCP), a signaling pathway conserved from flies to humans. An exce... | Non-SBIR/STTR | 6project_grants_public |
gen_62308e30dfc30e43c1a26ae53fdeeb2e | Optimization of CAR-Bacteria for Oral Cancer | NIH | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 5R21CA280794-02 | ABSTRACT The goal of this project is to explore the feasibility of generating Chimeric Antigen Receptors (CARs) expressed by bacteria. Instead of using T cells, we propose to explore the idea and use of bacteria to mediate the targeted destruction of cancer cells. In addition, we explore the possibility that we could ... | Non-SBIR/STTR | 6project_grants_public |
gen_f72422252cface0faf072dfffa7360bb | Modeling Susceptibility to Radiation Therapy-induced Cardiotoxicity Using Cell Village iPSCs | NIH | STANFORD UNIVERSITY | 1R01HL171102-01 | Project Summary Radiation therapy (RT) is an important component of cancer treatments, yet its usage has been hampered due to cardiovascular side effects. Although RT-induced heart disease (RIHD) disproportionally affects cancer patients, the mechanisms underlying RIHD susceptibility remains elusive. In this multi-PI R... | Non-SBIR/STTR | 6project_grants_public |
gen_1bb1fa25af5663c04b6646fbb1edde0e | Research Experience and Mentorship as Critical Interventions to Advance Diversity in Biomedical Science | NIH | CLAREMONT GRADUATE UNIVERSITY | 1R01GM151513-01 | Diversifying the biomedical workforce is imperative to meet the healthcare needs of the U.S. population. It is a long journey from being an undergraduate science major to becoming a scientific researcher, often more so for students from underrepresented groups. Some students persist, yet the majority leave the scientif... | Non-SBIR/STTR | 6project_grants_public |
gen_60cfbedf4729bf3cc747d917fe292d48 | Assessing residential neighborhood exposome exposures and the associations with cancer incidence | NIH | VIRGINIA COMMONWEALTH UNIVERSITY | 5R01CA277780-02 | Colorectal, lung, and female breast cancers are major public health burdens and there are clear geographic and racial/ethnic disparities in their incidence. Each of these cancers has been linked to neighborhood factors including socioeconomic deprivation, the built environment, and environmental pollutants in attempts ... | Non-SBIR/STTR | 6project_grants_public |
gen_a93fd1360527116e7b791f5215afab7b | Characterization of the RRS: a new chromosomal structural element in E. coli | NIH | UNIVERSITY OF WISCONSIN-MADISON | 1R21AI179102-01 | Project Summary/Abstract Bacterial chromosomes are highly structured in order to accommodate their large size in a relatively small cellular package. In E. coli, the chromosome is divided into 31 chromosomal interaction domains (CIDs) and several larger and topologically isolated macrodomains. The structures defining m... | Non-SBIR/STTR | 6project_grants_public |
gen_74191e88d74d86d2be17f2c125f72a56 | Mechanoimmunological interactions between TCR-T cells and tumor fibrotic microenvironment | NIH | STATE UNIVERSITY OF NEW YORK AT BUFFALO | 5R01CA273929-02 | Adoptive cellular therapies (ACT), including the two modalities: Engineered T Cell Receptor (TCR) Therapy and Chimeric Antigen Receptor (CAR) T Cell Therapy, are currently at the forefront of cancer immunotherapy. While CAR-T therapies has gained clinical success in the treatment of hemopoietic cancers and are approved... | Non-SBIR/STTR | 6project_grants_public |
gen_b8dcf8971cbc1d3a493b6c99820a24e1 | Determinants of cardioprotection by circulating prohibitin-1 during sepsis | NIH | UNIVERSITY OF IOWA | 1R01HL167087-01 | ABSTRACT: Sepsis is a dangerous hyper-inflammatory condition that carries a mortality rate of 25% for uncomplicated cases and rises to 80% for patients who develop multiple organ dysfunction syndrome (MODS). No specific therapies for MODS exist, which is why identification of druggable targets and biomarkers for diagno... | Non-SBIR/STTR | 6project_grants_public |
gen_90bbfbf43985c77db29bd5dd4a494007 | Regulation of Kir4.1/Kir5.1 and renal potassium excretion | NIH | NEW YORK MEDICAL COLLEGE | 1R01DK136491-01 | Maintaining K+ homeostasis is essential for the function of heart, skeletal muscles and neurons because hypokalemia or hyperkalemia could cause life-threatening consequence such as cardiac arrhythmia. A recent development in the field has firmly established the role of thiazide-sensitive Na-Cl cotransporter (NCC) in th... | Non-SBIR/STTR | 6project_grants_public |
gen_301beebee66307cc3f0b820e50cd014d | Methods Training for Comparative Effectiveness Research in Cancer | NIH | UNIVERSITY OF TX MD ANDERSON CAN CTR | 5R25CA278726-02 | Comparative effectiveness research (CER) aims to inform healthcare decisions by providing evidence on the benefits and harms of different alternatives in cancer care. While randomized controlled trials are often considered to be the gold standard of research and have high internal validity due to their controlled envir... | Other Research-Related | 6project_grants_public |
gen_d1a2f74212ca3cdb95bce703e884a736 | Autoimmune Drivers and Protectors Team Science (ADAPTS) | NIH | OKLAHOMA MEDICAL RESEARCH FOUNDATION | 5U01AI176244-02 | Project Summary Systemic lupus erythematosus (SLE) is a heterogeneous, systemic autoimmune disease that causes significant morbidity and early mortality, especially in minority populations and in women of child-bearing age. By the time patients reach SLE classification, the majority exhibit organ/tissue damage and ong... | Non-SBIR/STTR | 6project_grants_public |
gen_6ad2c8d9f87381d7509e4fb599750589 | Immunotherapeutic targeting of MIF-dependent chaperone activity | NIH | UNIVERSITY OF LOUISVILLE | 1R01CA279748-01 | PROJECT SUMMARY “Immunotherapeutic targeting of MIF-dependent chaperone activity” Metabolic reprogramming that favors mitochondrial respiration plays an important role in controlling differential gene expression patterns in myeloid lineage cells. Our recent findings have identified a novel protein chaperone-dependent... | Non-SBIR/STTR | 6project_grants_public |
gen_30001d025c63212e9178dade97292ed2 | Comparing the effects of pharmacological treatment for gestational diabetes on long-term maternal and child health outcomes | NIH | KAISER FOUNDATION RESEARCH INSTITUTE | 1R01DK138135-01 | Abstract Gestational diabetes mellitus (GDM) is among the most common complications of pregnancy and it increases the risk of perinatal complications and long-term sequelae for both the mother (subsequent diabetes) and the exposed child (obesity). Up to 50% of patients with GDM require the addition of pharmacologic the... | Non-SBIR/STTR | 6project_grants_public |
gen_071bf82a2e7c12090a64fd1eb9130f13 | The role of DNAJB1-PKAc-β-catenin axis in fibrolamellar HCC | NIH | CINCINNATI CHILDRENS HOSP MED CTR | 5R01CA278834-02 | Abstract This multiple-PI application proposes investigations of cellular and molecular mechanisms of Fibrolamellar Hepatocellular Carcinoma, FLC. FLC is a disease that occurs in children, adolescents and in young adults without a history of other liver disorders such as fibrosis or cirrhosis. Numerous studies in FLC p... | Non-SBIR/STTR | 6project_grants_public |
gen_320c7e7fb21847f14d2cd6f575eff51d | Revealing the role of blood microbiome in childhood asthma | NIH | BRIGHAM AND WOMEN'S HOSPITAL | 1K99HL163519-01A1 | Project Summary/Abstract Asthma is one of the most common chronic respiratory diseases worldwide. Microbial dysbiosis in the gut and lungs has increasingly been associated with the incidence and severity of asthma, indicating the potential of the microbiome to be a determinant factor in asthma pathogenesis. However, as... | Other Research-Related | 6project_grants_public |
gen_8ac82ee03dd830b8054c242060f6e2df | Innate immune regulation of wound re-epithelialization | NIH | UT SOUTHWESTERN MEDICAL CENTER | 4R00AR072780-03 | PROJECT SUMMARY/ABSTRACT Skin has a remarkable ability to heal wounds through re-epithelialization, a repair process fueled by adult stem cells residing in the epidermis and hair follicles. Following injury, wound-edge keratinocytes proliferate and migrate to initiate wound closure, which is accompanied by activation a... | Non-SBIR/STTR | 6project_grants_public |
gen_71759cafb4868d0df54bec135124f2e0 | Physiological changes underlying the weight loss plateau in humans | NIH | UNIVERSITY OF WASHINGTON | 1R01DK134417-01A1 | Behavioral strategies for obesity treatment reliably result in weight loss and health benefits. However, weight loss typically plateaus at ~7–10% of total body weight (a plateau phase) after which weight regain is common, limiting the ability of most intervention strategies to modify obesity-related disease risk in a s... | Non-SBIR/STTR | 6project_grants_public |
gen_bb5d4631f835213073c69c6688014cca | Determining the mechanism of IFIH1 disease-associated variants on beta-cell and immune responses in Type 1 diabetes | NIH | UNIVERSITY OF KANSAS MEDICAL CENTER | 7R01DK127497-04 | Project Summary/Abstract Type 1 diabetes (T1D) is a multifactorial autoimmune disease that requires genetic susceptibility as well as environmental triggers such as viral infections in triggering disease onset. One viral infection that is highly correlated with T1D is the Coxsackievirus B (CVB) serotype. Sensing of CVB... | Non-SBIR/STTR | 6project_grants_public |
gen_9f0e4f79efb4807fb16dd5ee8bc1374a | Determinants of Convalescent and Vaccine-induced Mucosal Specific Immunity to SARS-CoV-2 and Variants of Concern in Children with Asthma | NIH | UNIVERSITY OF VIRGINIA | 5R01AI176171-02 | PROJECT SUMMARY/ABSTRACT In the wake of a global pandemic caused by the ancestral strain of SARS-CoV-2, infections with emerging variant strains are an ongoing cause of morbidity and mortality. Robust respiratory mucosal immune responses to SARS-CoV-2 infection and/or vaccination are vital to prevent re-infection and c... | Non-SBIR/STTR | 6project_grants_public |
gen_bc74df65dc3ebb8577f89c164a0d287c | THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK AREA B | NIH | JOHNS HOPKINS UNIVERSITY | 75N92022D00002-0-759202400001-1 | The Atherosclerosis Risk in Communities (ARIC) Study was initiated in 1985 with two components: community-based surveillance and a prospective cohort study. The community surveillance aimed to monitor trends in hospitalized myocardial infarction (MI), fatal coronary heart disease (CHD) in four U.S. communities: Forsyth... | R and D Contracts | 6project_grants_public |
gen_57685ea0f231cb87c84927786489c536 | Cis regulatory control of avian bill morphogenesis | NIH | PRINCETON UNIVERSITY | 5K00DE030326-04 | The neural crest is a multipotent embryonic cell population that gives rise to most of the craniofacial skeleton, including cartilage, bone and connective tissue. Misregulation of neural crest development results in the vast majority of craniofacial malformations and birth defects. Thus, uncovering the molecular and ge... | Other Research-Related | 6project_grants_public |
gen_5188c32a24a01c9fabe6584a7fe42405 | Determining the impact of ultra-small SIV reservoirs on sustained ART-free remission | NIH | UNIVERSITY OF WISCONSIN-MADISON | 1R56AI174940-01 | Abstract/Summary Antiretroviral therapy (ART) effectively controls HIV replication, but it is not a cure. Therefore, considerable efforted is devoted to developing cure regimens that reduce viral reservoirs and boost antiviral immunity. These interventions seek to permit people with HIV (PWH) to stop ART and durably co... | Non-SBIR/STTR | 6project_grants_public |
gen_587b55c091860bae7c285ce2063bc70f | Cardiac Regenerative Therapy Using Gene-Edited Stem Cells to Improve Transplantation Outcomes | NIH | UNIVERSITY OF CALIFORNIA AT DAVIS | 1R56HL167932-01 | Cardiovascular disease is the leading cause of morbidity and mortality in the United States. A significant loss of cardiomyocytes from myocardial infarction (MI) can result in progressive deterioration of cardiac function. Many patients do not recover their cardiac function despite optimal medical therapies and develop... | Non-SBIR/STTR | 6project_grants_public |
gen_1a0a6649035cf364f267a5d0d47153e9 | Cryostat for generation of superfluid helium droplets | NIH | OREGON STATE UNIVERSITY | 3R01GM149881-02S1 | We plan to add an electron diffraction component to a native protein mass spectrometer to create a new instrument that can derive atomic structures of macromolecules such as proteins. The key innovation is the use of superfluid helium droplets for sample cooling thereby effective field induced orientation and alignment... | Non-SBIR/STTR | 6project_grants_public |
gen_b632e223d9240060807bca11e27bccf4 | Venous Thromboembolism Sequelae in a Population-based Inception Cohort | NIH | KAISER FOUNDATION RESEARCH INSTITUTE | 5R01HL166292-02 | PROJECT SUMMARY / ABSTRACT Nearly 1 million Americans each year experience a first venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE). VTE is typically viewed as an acute event that is treatable by anticoagulants, with less focus on chronic adverse VTE sequelae or on reh... | Non-SBIR/STTR | 6project_grants_public |
gen_2ac9b764165b97be8319403e4dabf853 | Airway Prevotella enhance innate immune-mediated protection against lung infection | NIH | UNIVERSITY OF COLORADO DENVER | 1R01AI172958-01 | Project Summary These studies address the large gap in knowledge regarding how commensal bacteria in the airway protect against bacterial pneumonia. Next generation sequencing studies of the airway microbiome have revealed that specific respiratory bacteria are associated with a reduced abundance of Streptococcus pneum... | Non-SBIR/STTR | 6project_grants_public |
gen_17e7601b3528b4b874405c98eaecccb7 | The 3E Study: Economic and Educational Contributions to Emerging Adult Cardiometabolic Health | NIH | FORDHAM UNIVERSITY | 1R01HL160703-01A1 | Emerging adulthood represents a uniquely sensitive period for studying social determinants of health in the United States (US), as young people begin to establish their own paths towards higher education, careers, and financial independence. College, specifically, is a time of changing socioeconomic position (SEP) that... | Non-SBIR/STTR | 6project_grants_public |
gen_bd13c23547e56d1fddeb8f1960b71088 | Role of RNA helicase Ddx5 in pathological cardiac remodeling | NIH | COLUMBIA UNIVERSITY HEALTH SCIENCES | 5R01HL170132-02 | Abstract This new R01 proposal explores novel mechanisms underlying RNA regulation in heart failure (HF), a major global health concern with high morbidity and mortality. The PI is an advanced HF cardiologist, who studies transcriptional regulation in HF and myocardial recovery. Based on data generated with support fro... | Non-SBIR/STTR | 6project_grants_public |
gen_2ab8627fa48379f15e146b0f34c901c1 | Improving the Quality of Heart Failure Care for American Indian Patients Receiving Care through the Indian Health Service | NIH | UNIVERSITY OF PENNSYLVANIA | 5K23HL166974-02 | PROJECT SUMMARY/ABSTRACT Heart failure morbidity and mortality disproportionately impact racial minorities, and inequitable care delivery based on race is pervasive in the United States. While the American Indian/Alaska Native population is one of the populations that suffers most from health disparities, little is kno... | Other Research-Related | 6project_grants_public |
gen_91cd4e0a41d3a3cb75b051181c01e903 | Systems Biology of Tumor-Immune-Stromal Interactions in Metastatic Progression | NIH | STANFORD UNIVERSITY | 1U54CA274511-01A1 | ABSTRACT/SUMMARY – Overall Distant metastasis is the primary cause of cancer-related death. To colonize distant tissues, cancer cells must migrate while evading elimination by the immune system. Evidence suggests that key steps in the induction process of immune tolerance occur early in the metastatic cascade, located ... | Research Centers | 6project_grants_public |
gen_d184a778bfbd100db4b0d1c678a80b2b | Applying causal inference methods to improve estimation of the real-world benefits and harms of lung cancer screening | NIH | UNIV OF NORTH CAROLINA CHAPEL HILL | 1R01CA277756-01A1 | ABSTRACT Randomized controlled trials have demonstrated that low-dose computed tomography can substantially reduce lung cancer mortality, albeit at the cost of relatively high rates of false positives and complications from downstream procedures. However, systematic differences between trial and general populations eli... | Non-SBIR/STTR | 6project_grants_public |
gen_74ccc76fa7f5b71045f7693460f404d5 | Consequences of Maternal Vaping on Cerebrovascular Health in Offspring | NIH | WEST VIRGINIA UNIVERSITY | 1F31ES034646-01 | Project Summary/Abstract Electronic cigarettes (E-cigs) are promoted as an alternative to smoking during pregnancy, however the immediate and long-term effects are still unknown. Current estimates are that 5-16% of pregnant women will use e-cigs with the expectation that are either ‘reduced’ or ‘no’ risk to offspring h... | Training, Individual | 6project_grants_public |
gen_a73769f6007b79731014000be9491676 | Elucidating the Cellular Origins of lung adenocarcinoma | NIH | UNIVERSITY OF SOUTHERN CALIFORNIA | 1R01CA262258-01A1 | Lung cancer is responsible for the most cancer-related deaths in the United States, and Lung adenocarcinoma (LUAD) is the major histologic subtype. LUAD presents clinically with four major histologic subtypes (lepidic, acinar, papillary and solid), has variable presentation of EGFR and Kras mutations depending on ethni... | Non-SBIR/STTR | 6project_grants_public |
gen_bfe56c8d3430c6f14ddf6014b9ae628f | Free-living and in-lab effects of sedentary time on cardiac autonomic nervous system function in youth with overweight/obesity | NIH | UNIVERSITY OF SOUTHERN CALIFORNIA | 5F31HL164032-02 | PROJECT ABSTRACT Cardiovascular disease (CVD) is a significant public health burden and remains the leading cause of mortality among the U.S population. CVD progression can originate during childhood, and youth with overweight and obesity (OW/OB) have an increased risk for CVD development. One mechanism that contribute... | Training, Individual | 6project_grants_public |
gen_4322f33c693a40bf92df26ac68af435e | Deciphering the roles of eosinophils and T lymphocytes in EGID | NIH | NORTHWESTERN UNIVERSITY AT CHICAGO | 1K23AI171085-01A1 | ABSTRACT Dr. Fei Li Kuang is an Assistant Professor in the Division of Allergy and Immunology at Northwestern University Feinberg School of Medicine. Her clinical and research interests focus on eosinophilic disorders, including eosinophilic gastrointestinal disorders (EGIDs), inflammatory diseases defined by excessive... | Other Research-Related | 6project_grants_public |
gen_8a3bd7d82dc714892e17d95e60fcb7c7 | Sustained Release of Potent Antiviral Prodrugs for HIV Prevention | NIH | OAK CREST INSTITUTE OF SCIENCE | 1R01AI172541-01A1 | ABSTRACT Important progress in curbing the progression of the HIV epidemic has been achieved, but new HIV infection rates are outpacing the targets set by global health organizations: in 2019, an estimated 1.7 million people became newly HIV infected worldwide. New HIV pre-exposure prophylaxis (PrEP) strategies are nee... | Non-SBIR/STTR | 6project_grants_public |
gen_3e229a7f071a4648d636f23eb6a360b2 | Defining the role of IL-18 in atopic dermatitis | NIH | WASHINGTON UNIVERSITY | 1R01AI176660-01 | ABSTRACT Atopic dermatitis (AD) is an increasingly common relapsing-remitting skin disease characterized by chronic allergic inflammation and itch. The etiology of AD is unknown, but type 2 cytokines, particularly interleukin (IL)- 4 and IL-13, are involved in driving AD and AD-like pathology, as demonstrated by the ef... | Non-SBIR/STTR | 6project_grants_public |
gen_05f4f3272d717bb60db81702cfd927b2 | Genetic Markers of Chronic Postsurgical Pain | NIH | UNIVERSITY OF MICHIGAN AT ANN ARBOR | 5K08AR082454-02 | PROJECT SUMMARY / ABSTRACT Over 100 million surgical procedures are performed in the United States each year, with up to 80% of patients experiencing postoperative pain. Higher levels of pain after surgery are associated with the development chronic post-surgical pain (CPSP) and chronic opioid use, feeding into a pain ... | Other Research-Related | 6project_grants_public |
gen_b9fb720d4e93f816df49d4604710417b | Predictive Markers for Longitudinal TMJ Integrity | NIH | STATE UNIVERSITY OF NEW YORK AT BUFFALO | 5R03DE032807-02 | Project Summary/Abstract Temporomandibular disorders (TMDs) are prevalent, with estimates of 5% to 10%, with two-fold higher prevalence for females than males (NASEM, 2020), and projected annual costs of $4 billion (Stowell et al. 2007). TMD represents a group of conditions with and without pain, such as temporomandibu... | Non-SBIR/STTR | 6project_grants_public |
gen_b63d82b767b364742490d7639c695d5b | The Clinical Relevance of Anthracycline-Related Cardiac Remodeling in Childhood Cancer Survivors | NIH | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 5K23HL163456-02 | PROJECT SUMMARY/ABSTRACT Anthracycline antibiotics are essential, lifesaving chemotherapies used in ~60% of pediatric cancer patients, but they confer a substantial dose-dependent risk of cardiac dysfunction and heart failure in long-term survivors. The standard heart failure management approach -- waiting for left ve... | Other Research-Related | 6project_grants_public |
gen_267deb20a4937a7aa807172d92e5bce5 | Molecular Phenotyping of ARDS, Pneumonia, and Sepsis using Latent Class Analysis and Metagenomic Sequencing | NIH | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | 1U01HL168415-01 | ABSTRACT This application to RFA HL-23-001 proposes a California Clinical Center for participation in the Acute Respiratory Distress Syndrome (ARDS), Pneumonia, and Sepsis (APS) Consortium study. Our Clinical Center consists of 4 sites: University of California, San Francisco (UCSF; lead site); UCSF Fresno; Zuckerberg... | Non-SBIR/STTR | 6project_grants_public |
gen_9555632aba7a1e94c8faaae1e68c2445 | Helping Doctors Doctor: Using AI to Automate Documentation and "De-Autonomate" Health Care | NIH | UNIVERSITY OF PENNSYLVANIA | 1DP1LM014558-01 | Johnson, Kevin DP1 Details Project Name: Helping Doctors Doctor: Using AI to Automate Documentation and “De-Autonomate” Health Care Project Summary Clinical encounter documentation is one of the most time-consuming tasks of the ambulatory encounter, taking approximately two hours for every hour spent with patients. Cli... | Non-SBIR/STTR | 6project_grants_public |
gen_2e6712567ecbd244f91469b5795915b0 | Selective Radionuclide Delivery for Precise Bone Marrow Niche Alterations | NIH | FRED HUTCHINSON CANCER CENTER | 5R21CA283589-02 | PROJECT SUMMARY / ABSTRACT The bone marrow niche houses hematopoietic stem cells (HSCs), cells that self-renew and differentiate into vital blood components like white blood cells, red blood cells, and platelets. HSCs are supported by other marrow resident cells, like vascular endothelial cells and stromal cells, that ... | Non-SBIR/STTR | 6project_grants_public |
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