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NCT01701986
|
20:29:chronic_disease,,,43:57:chronic_disease,75:94:chronic_disease,98:118:chronic_disease
|
Evidence of either cirrhosis or stage 3-4 liver fibrosis in patients with chronic hepatitis C or positive hepatitis C serology
| 3
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NCT02111850
|
37:62:treatment,,107:116:treatment,183:199:cancer
|
Lesions that have been treated with stereotactic radiosurgery must be clinically stable for 1 month after treatment for the patient to be eligible. Patients with surgically resected brain metastases are eligible
| 3
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NCT03101956
|
1:30:chronic_disease
|
Lumbar nerve root compression (any of the following signs present)
| 3
|
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NCT01902810
|
29:53:treatment
|
Medical condition requiring glucocorticoid treatment
| 3
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NCT01943851
|
24:48:chronic_disease,52:63:chronic_disease,79:98:chronic_disease
|
Clinically significant conduction abnormalities or arrhythmias, subjects with Bundle Branch Block
| 3
|
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NCT02522468
|
1:7:treatment,15:38:cancer,67:92:cancer,94:120:cancer,126:150:cancer
|
Biopsy-proven malignant breast lesion including by not limited to invasive ductal carcinoma, invasive lobular carcinoma, and ductal carcinoma in situ
| 3
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NCT03028012
|
12:29:chronic_disease
|
History of bleeding disorder
| 3
|
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NCT01624090
|
1:12:treatment
|
Clopidogrel
| 3
|
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"Clopidogrel"
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NCT02502799
|
9:31:chronic_disease
|
Current substance use disorder meeting DSM-IV criteria for the severe qualifier
| 3
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NCT02100891
|
30:40:chronic_disease
|
Patients with serious active infections
| 3
|
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NCT03034772
|
16:26:treatment,30:46:treatment,54:68:treatment,70:80:treatment
|
Any history of vitrectomy or glaucoma surgery (e.g., trabeculectomy, tube shunt)
| 3
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NCT02393794
|
32:125:treatment
|
Subject is currently receiving treatment with drugs known to be moderate or strong inhibitors or inducers of isoenzyme CYP3A
| 3
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NCT01861106
|
138:145:cancer
|
No mutation in GATA2, or in the case where the mutation in GATA2 has not been identified, but the recipient has the clinical syndrome of MonoMAC, the donor is required to have no clinical evidence of MonoMAC
| 3
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NCT02331095
|
5:15:cancer,,67:90:cancer,94:122:cancer,136:151:treatment,161:192:cancer
|
Any malignancy diagnosed within the preceding 2 years, except for squamous cell carcinoma or basal cell carcinoma of skin treated with local resection only, or carcinoma in situ of the cervix
| 3
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NCT01059786
|
,,58:67:chronic_disease,
|
Bilirubin less than or equal to 2 unless consistent with Gilbert s (total/direct greater than 5)
| 3
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NCT02413970
|
7:23:chronic_disease,,
|
Has a terminal illness with life expectancy < 12 months
| 3
|
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NCT02347891
|
1:13:treatment,15:27:treatment,29:50:treatment,52:63:treatment,65:75:treatment,77:89:treatment,94:127:treatment
|
azathioprine, methotrexate, mycophenolate mofetil, leflunomide, tacrolimus, cyclosporine, or intravenous gamma globulin [IVIG]
| 3
|
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NCT02541903
|
1:19:chronic_disease
|
ulcerative colitis
| 3
|
[
"ulcerative",
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[
2,
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] |
NCT01688388
|
1:6:cancer,24:29:cancer,33:58:cancer,106:124:cancer,
|
Tumor. Single discrete tumor or focal microcalcifications that can be imaged on a specimen radiograph or multifocal disease within the same quadrant with a maximum dimension of equal to or less than 2.5 cm
| 3
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NCT02343042
|
37:61:chronic_disease,83:106:chronic_disease,110:125:treatment
|
Uncontrolled clinically-significant conduction abnormalities (e.g., patients with ventricular tachycardia on antiarrhythmics
| 3
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NCT02382419
|
5:31:treatment,35:75:cancer,79:91:treatment
|
Any previous surgical excision of cervical intraepithelial neoplasia (CIN) or hysterectomy
| 3
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NCT02414269
|
5:19:treatment,21:32:treatment,46:66:treatment,82:92:treatment,
|
Any major thoracic (thoracotomy with lung or esophageal resection) or abdominal (laparotomy with organ resection) operation must have occurred at least 28 days before study enrollment
| 3
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NCT02931110
|
1:25:cancer,95:108:treatment,101:108:treatment
|
Hematological malignancy has been previously treated, has relapsed after or progressed during prior therapy, and has limited potential for benefit from currently available therapy
| 3
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NCT02128906
|
40:59:treatment
|
No prior severe infusion reaction to a monoclonal antibody
| 3
|
[
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NCT01625923
|
12:27:chronic_disease
|
History of eating disorder
| 3
|
[
"History",
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"disorder"
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[
0,
0,
2,
2
] |
NCT02313428
|
1:35:cancer
|
Active malignancy at site of ulcer
| 3
|
[
"Active",
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"ulcer"
] |
[
3,
3,
3,
3,
3,
3
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NCT02516696
|
51:70:chronic_disease
|
Subject has any clinically significant medical or psychiatric disease or condition that, in the Investigator's opinion, may interfere with protocol adherence or a subject's ability to give informed consent
| 3
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NCT02519322
|
21:35:treatment,37:49:treatment,51:68:treatment,70:83:treatment,88:104:treatment,109:141:treatment
|
Currently receiving cancer therapy (chemotherapy, radiation therapy, immunotherapy, or biologic therapy) or investigational anti-cancer drug
| 3
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NCT02946892
|
28:60:chronic_disease
|
Uncorrected obstructive or severe regurgitant valve disease
| 3
|
[
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[
0,
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NCT02737930
|
11:55:chronic_disease
|
Premorbid monocular or binocular visual field deficits
| 3
|
[
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[
0,
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NCT02037139
|
21:33:chronic_disease
|
Screen positive for hearing loss using single question and/or finger rub
| 3
|
[
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"loss",
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NCT02453113
|
8:25:chronic_disease,27:43:chronic_disease,45:62:chronic_disease,67:80:chronic_disease
|
Use of systemic steroids, topical steroids, tanning solutions and anticoagulant
| 3
|
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NCT02327403
|
1:8:chronic_disease
|
EBV IgG negative
| 3
|
[
"EBV",
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[
2,
2,
0
] |
NCT01464034
|
7:23:chronic_disease,43:54:treatment,56:66:treatment,71:82:treatment,
|
Acute active infection requiring systemic antibiotics, antivirals, or antifungals within 14 days prior to first dose
| 3
|
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NCT00670358
|
10:22:treatment,,
|
No prior radiotherapy to ≥ 25% of the bone marrow
| 3
|
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NCT01130077
|
,,,,108:119:treatment,,,,,,,,,,
|
Patients with adequate organ function as measured by: Bone marrow: ANC > 1,000/µl; Platelets > 100,000/µl (transfusion independent); absolute lymphocyte count of ≥500/uL; Hemoglobin >8 g/dl (may be transfused). Hepatic: bilirubin ≤ 1.5x institutional normal for age; SGPT (ALT) < 3x institutional normal
| 3
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NCT02393157
|
53:58:cancer
|
Patients with newly diagnosed, previously untreated B-NHL
| 3
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NCT01827384
|
26:65:cancer,84:93:treatment,122:130:chronic_disease,163:184:treatment,
|
Patients with history of central nervous system (CNS) metastases who have received treatment and who either have not had seizures or have been on stable doses of anti-seizure medicine and had no seizures for 4 weeks
| 3
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NCT02481765
|
1:16:chronic_disease,8:16:chronic_disease,50:58:chronic_disease,67:79:chronic_disease,
|
Active epilepsy, history of epilepsy, history of seizures or with epileptiform discharges on screening baseline EEG
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NCT02524275
|
79:103:chronic_disease,129:166:chronic_disease,168:183:chronic_disease,208:218:chronic_disease,278:290:treatment
|
Uncontrolled intercurrent illnesses including, but not limited to symptomatic congestive heart failure, severe oxygen dependent chronic obstructive pulmonary disease, unstable angina or uncontrolled cardiac arrhythmia that could jeopardize the subject?s ability to receive the chemotherapy described in the protocol safely
| 3
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NCT03009981
|
1:8:cancer,29:47:treatment,54:58:treatment,62:73:treatment,102:104:treatment,112:115:treatment,119:141:treatment
|
Lesions identified on other imaging modalities (e.g. PSMA or choline PET) that are not visualized on CT and/or MRI or radionuclide bone scan
| 3
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NCT02074631
|
22:49:treatment,,91:99:treatment,112:127:treatment,129:138:treatment,143:155:treatment
|
Prior and/or planned concomitant medical therapy during the study period (through Day 360 post-HCT) with other bisphosphonates, Denosumab, or Teriparatide
| 3
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NCT01720836
|
34:44:chronic_disease
|
Subjects with a history of known autoimmune
| 3
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NCT02465060
|
5:17:treatment
|
the radiotherapy must not be to a lesion that is included as measurable disease
| 3
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NCT01464034
|
,,,,65:76:treatment,,
|
Additional Laboratory Requirements ANC ≥1.0 x 109/L Hgb ≥8 g/dL(transfusion permitted) Platelet count ≥50.0 x 109/L
| 3
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NCT02340650
|
20:30:treatment
|
who are undergoing cystoscopy as part of their routine clinical care
| 3
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NCT02393885
|
12:27:chronic_disease,
|
Documented thromboembolism within the previous six months prior to signing informed consent
| 3
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NCT03035474
|
7:23:treatment
|
Prior heart transplant or current/planned left ventricular assistance device
| 3
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NCT02525861
|
76:93:chronic_disease,106:150:chronic_disease,152:161:chronic_disease,163:181:chronic_disease,188:202:chronic_disease,215:221:chronic_disease
|
The participant is experiencing or has a history of clinically significant pulmonary disease (other than chronic obstructive pulmonary disease (COPD), emphysema, chronic bronchitis, mild bronchiectasis, and stable asthma)
| 3
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NCT01720836
|
7:18:chronic_disease,22:38:treatment,45:55:treatment
|
Known Hepatitis B on immunomodulators (i.e. interferon)
| 3
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NCT03034811
|
1:13:chronic_disease
|
Osteomalacia
| 3
|
[
"Osteomalacia"
] |
[
2
] |
NCT01851369
|
,,72:82:treatment,72:83:treatment,219:228:treatment
|
Pregnant women are excluded from this study because the effects of the study drugs on the developing fetus are unknown. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with the study drugs, breastfeeding should be discontinued prior to the first dose of study drug and women should refrain from nursing throughout the treatment period and for 3 months following the last dose of study drug
| 3
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NCT01993810
|
28:46:treatment,,66:88:treatment,,111:127:treatment
|
Patients who have received systemic treatment (up to 4 cycles of induction chemotherapy, or up to 6 months of targeted therapy)
| 3
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NCT02332369
|
1:15:chronic_disease
|
Microphthalmia
| 3
|
[
"Microphthalmia"
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[
2
] |
NCT01859819
|
15:30:chronic_disease,54:68:treatment,70:82:treatment,97:111:treatment
|
Patients with G6PD deficiency should be treated with alkalinization, IV hydration and po and/or IV allopurinol during the reduction phase (COP)
| 3
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NCT02400463
|
27:36:chronic_disease,,
|
reported history of liver cirrhosis with a Model for End-stage Liver Disease (MELD) score >20
| 3
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NCT03008408
|
1:40:treatment,44:68:chronic_disease,140:158:chronic_disease,173:179:chronic_disease,181:189:chronic_disease,191:199:chronic_disease,201:223:chronic_disease,201:214:chronic_disease,227:248:treatment
|
Impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of study medication (e.g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome or small bowel resection associated with malabsorption
| 3
|
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NCT02579265
|
11:24:chronic_disease
|
Suspected liver disease
| 3
|
[
"Suspected",
"liver",
"disease"
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[
0,
2,
2
] |
NCT02414139
|
24:49:chronic_disease,53:77:chronic_disease,112:133:treatment
|
Presence or history of interstitial lung disease or interstitial pneumonitis, including clinically significant radiation pneumonitis
| 3
|
[
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NCT02397083
|
28:52:treatment,,79:89:treatment,253:273:treatment,275:282:treatment,284:289:treatment,291:298:treatment,300:310:treatment,312:342:treatment,344:356:treatment,358:367:treatment,372:394:treatment
|
Patients who have received live attenuated vaccines within 1 week of start of everolimus and during the study; patient should also avoid close contact with others who have received live attenuated vaccines; examples of live attenuated vaccines include intranasal influenza, measles, mumps, rubella, oral polio, Bacillus Calmette-Guerin (BCG), yellow fever, varicella and TY21a typhoid vaccines
| 3
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NCT02864862
|
46:66:treatment
|
The reasons for extraction will include poor endodontic prognosis
| 3
|
[
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[
0,
0,
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0,
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NCT02233868
|
1:18:treatment
|
antihypertensives
| 3
|
[
"antihypertensives"
] |
[
1
] |
NCT01522768
|
52:64:treatment,,
|
Patients who are unwilling to consent to mandatory tumor biopsy. Patients with archival tissue permitted to enroll on study per MSK Principal Investigator discretion Women who are pregnant or breast feeding
| 3
|
[
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NCT02075047
|
18:25:chronic_disease
|
Imminent risk of suicide or homicide
| 3
|
[
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"suicide",
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"homicide"
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[
0,
0,
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2,
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0
] |
NCT02446236
|
1:14:treatment,30:46:chronic_disease,,83:93:treatment
|
Major surgery or significant traumatic injury within 28 days of the first dose of study drug
| 3
|
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NCT02515110
|
22:34:treatment,39:52:cancer,109:130:treatment,,
|
Interval between the last surgery for breast cancer (including re-excision of margins) or the completion of adjuvant chemotherapy and study enrollment must be =< 56 days (ie, a maximum of 8 weeks)
| 3
|
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NCT01568177
|
1:40:chronic_disease
|
hypertrophic obstructive cardiomyopathy
| 3
|
[
"hypertrophic",
"obstructive",
"cardiomyopathy"
] |
[
2,
2,
2
] |
NCT02101736
|
,38:58:treatment
|
At least 4 weeks since receiving any investigational drug
| 3
|
[
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"weeks",
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[
0,
0,
0,
0,
0,
0,
0,
1,
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NCT00579514
|
50:70:cancer,72:79:cancer,81:87:cancer,89:94:cancer,96:105:cancer,107:112:cancer,114:122:cancer,127:146:cancer,171:179:cancer
|
MSKCC patients without a histologic diagnosis of cancer of the breast, bladder, kidney, colon, testicles, lungs, prostate, or lymphoid malignancy (including all types of lymphoma) will not be eligible for the AMDeC sponsored component of the study
| 3
|
[
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NCT01730118
|
32:43:cancer,74:84:cancer,85:97:cancer,121:139:treatment,172:189:treatment
|
with malignant soft tissue and bone tumors and recurrent or progressive, metastatic solid tumors who have progressed on standard therapies with known benefit but for whom anti-HER2 therapy is not clinically indicated
| 3
|
[
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"soft",
"tissue",
"and",
"bone",
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NCT02924402
|
,,52:70:treatment
|
Failure to recover from Grade 3 or 4 toxicity from previous treatment
| 3
|
[
"Failure",
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0,
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0,
0,
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NCT02361944
|
1:16:treatment
|
Cardiac surgery that requires intraoperative circulatory arrest, such as aortic arch replacement
| 3
|
[
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"surgery",
"that",
"requires",
"intraoperative",
"circulatory",
"arrest",
",",
"such",
"as",
"aortic",
"arch",
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[
1,
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0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
NCT02332850
|
1:24:treatment,28:40:treatment,,59:83:treatment,,120:135:treatment
|
Prior radiation therapy or chemotherapy within 2 weeks or major surgical procedure within 4 weeks of the first dose of study treatment
| 3
|
[
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"therapy",
"or",
"chemotherapy",
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] |
NCT02581982
|
18:28:cancer,61:77:treatment,98:118:cancer,134:157:cancer,201:217:treatment,221:244:cancer
|
Known additional malignancy that is progressing or requires active treatment; exceptions include basal cell carcinoma of the skin or squamous cell carcinoma of the skin that has undergone potentially curative therapy or in situ cervical cancer
| 3
|
[
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NCT02416102
|
16:51:treatment,55:80:treatment,82:106:treatment,108:123:treatment
|
Current use of nonsteroidal antiinflammatory drugs or potassium supplementation, treatment with aliskiren, anticoagulation
| 3
|
[
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NCT02555280
|
1:13:treatment,15:55:treatment,57:77:treatment,82:128:treatment
|
Prior fusion, implantation of a total disc replacement, complete laminectomy, or implantation of an interspinous process device at index level
| 3
|
[
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0,
0,
0,
0
] |
NCT02688959
|
12:16:chronic_disease
|
Documented ADHD diagnosis
| 3
|
[
"Documented",
"ADHD",
"diagnosis"
] |
[
0,
2,
0
] |
NCT01910818
|
61:65:allergy_name,67:74:allergy_name,78:95:allergy_name
|
Adverse reactions to compounds of any external agent (e.g., gels, lotions or anesthetic creams) required for use in the study, if no alternative to the said agent exists
| 3
|
[
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NCT02343042
|
1:21:chronic_disease
|
Symptomatic ischemia
| 3
|
[
"Symptomatic",
"ischemia"
] |
[
2,
2
] |
NCT03132636
|
12:24:cancer,36:39:cancer,82:92:cancer
|
Concurrent malignancies other than BCC, other than those with negligible risk of metastases or death
| 3
|
[
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"BCC",
",",
"other",
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0,
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] |
NCT01716806
|
1:35:treatment
|
Treatment-naïve patients with CD30-expressing PTCL (Part F)
| 3
|
[
"Treatment-naïve",
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"with",
"CD30-expressing",
"PTCL",
"(",
"Part",
"F",
")"
] |
[
1,
1,
1,
1,
0,
0,
0,
0,
0
] |
NCT01589263
|
12:36:chronic_disease,38:59:chronic_disease,61:86:chronic_disease,91:124:chronic_disease,
|
Episode of unstable angina pectoris, myocardial infarction, transient ischemic attack, or cerebrovascular accident (stroke) within the past 6 months
| 3
|
[
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"angina",
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",",
"myocardial",
"infarction",
",",
"transient",
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0,
0,
0,
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] |
NCT02317523
|
1:21:chronic_disease
|
Cognitive impairment
| 3
|
[
"Cognitive",
"impairment"
] |
[
2,
2
] |
NCT03152409
|
42:51:chronic_disease,61:67:chronic_disease,69:78:chronic_disease,80:103:chronic_disease
|
Active or recent (within the past month) infection (such as otitis, pneumonia, urinary tract infection)
| 3
|
[
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"(",
"within",
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"past",
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[
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2,
2,
2,
0
] |
NCT02508038
|
31:52:chronic_disease
|
Negative testing for relevant communicable diseases
| 3
|
[
"Negative",
"testing",
"for",
"relevant",
"communicable",
"diseases"
] |
[
0,
0,
0,
0,
2,
2
] |
NCT02418195
|
1:17:chronic_disease
|
Bipolar disorder
| 3
|
[
"Bipolar",
"disorder"
] |
[
2,
2
] |
NCT03113695
|
14:21:treatment,45:53:treatment,55:83:treatment,99:114:treatment,118:141:treatment
|
Able to take aspirin (81mg or 325mg) daily, warfarin, low molecular weight heparin, or equivalent anticoagulation as prophylactic medication
| 3
|
[
"Able",
"to",
"take",
"aspirin",
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"81mg",
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"325mg",
")",
"daily",
",",
"warfarin",
",",
"low",
"molecular",
"weight",
"heparin",
",",
"or",
"equivalent",
"anticoagulation",
"as",
"prophylactic",
"medication"
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0,
0,
0,
1,
0,
1,
1
] |
NCT01652092
|
1:41:chronic_disease
|
Hemophagocytic Lymphohistiocytosis (HLH)
| 3
|
[
"Hemophagocytic",
"Lymphohistiocytosis",
"(",
"HLH",
")"
] |
[
2,
2,
2,
0,
0
] |
NCT02833805
|
46:74:chronic_disease
|
Confirmed diagnosis of inherited or acquired severe aplastic anemia (SAA)
| 3
|
[
"Confirmed",
"diagnosis",
"of",
"inherited",
"or",
"acquired",
"severe",
"aplastic",
"anemia",
"(",
"SAA",
")"
] |
[
0,
0,
0,
0,
0,
0,
2,
2,
2,
2,
0,
0
] |
NCT02748109
|
38:60:chronic_disease
|
meet criteria for moderate to severe substance use disorder within the past month
| 3
|
[
"meet",
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"for",
"moderate",
"to",
"severe",
"substance",
"use",
"disorder",
"within",
"the",
"past",
"month"
] |
[
0,
0,
0,
0,
0,
0,
2,
2,
2,
0,
0,
0,
0
] |
NCT02366819
|
43:50:cancer,112:142:cancer,151:183:cancer
|
Histologically confirmed locally advanced gastric (primary endpoint includes proximal and mid-body stomach) or esophagogastric adenocarcinoma; distal gastric (antral) adenocarcinomas are eligible for enrolment but will not be included in the primary analysis
| 3
|
[
"Histologically",
"confirmed",
"locally",
"advanced",
"gastric",
"(",
"primary",
"endpoint",
"includes",
"proximal",
"and",
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"stomach",
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"or",
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"antral",
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"adenocarcinomas",
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NCT02056470
|
1:30:chronic_disease
|
active or suspected infection
| 3
|
[
"active",
"or",
"suspected",
"infection"
] |
[
2,
2,
2,
2
] |
NCT01618357
|
,,,117:124:treatment,126:135:treatment,140:149:treatment
|
Women of child-bearing potential must also have a negative pregnancy test within 2 weeks prior to start of protocol therapy (radiation and veliparib)
| 3
|
[
"Women",
"of",
"child-bearing",
"potential",
"must",
"also",
"have",
"a",
"negative",
"pregnancy",
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0,
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1,
0,
1,
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] |
NCT02461927
|
16:30:treatment
|
Current use of benzodiazepine
| 3
|
[
"Current",
"use",
"of",
"benzodiazepine"
] |
[
0,
0,
0,
1
] |
NCT01648023
|
39:50:cancer,
|
Patients with at least one measurable liver tumor, with size > 1cm
| 3
|
[
"Patients",
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"at",
"least",
"one",
"measurable",
"liver",
"tumor",
",",
"with",
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[
0,
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0
] |
NCT01970176
|
29:32:chronic_disease,,,119:143:chronic_disease,,,,,,350:367:chronic_disease,
|
A total of 39 patients with PSD as defined by an ejection fraction of less than 40%, no clinical signs or symptoms of congestive heart failure, a minimal distance on 6-minute walk of equal or >450 meters will be recruited and calculated creatinine clearance of equal or less than 90 ml/min and greater than 30 ml/min, using the (MDRD-measurement of renal dysfunction, formula) assessed within the past 24 months
| 3
|
[
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NCT02877381
|
23:44:chronic_disease,
|
major co-morbidities (myocardial infarction or stent placement within one year
| 3
|
[
"major",
"co-morbidities",
"(",
"myocardial",
"infarction",
"or",
"stent",
"placement",
"within",
"one",
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] |
[
0,
0,
0,
2,
2,
0,
0,
0,
0,
0,
0
] |
NCT03094663
|
1:10:chronic_disease
|
ASA of IV
| 3
|
[
"ASA",
"of",
"IV"
] |
[
2,
2,
2
] |
NCT01810588
|
1:17:cancer
|
Multiple myeloma
| 3
|
[
"Multiple",
"myeloma"
] |
[
3,
3
] |
NCT02020707
|
1:19:chronic_disease,54:88:chronic_disease,122:144:treatment
|
Immuno-compromised patients and patients known to be human immunodeficiency virus (HIV) positive and currently receiving antiretroviral therapy
| 3
|
[
"Immuno-compromised",
"patients",
"and",
"patients",
"known",
"to",
"be",
"human",
"immunodeficiency",
"virus",
"(",
"HIV",
")",
"positive",
"and",
"currently",
"receiving",
"antiretroviral",
"therapy"
] |
[
2,
0,
0,
0,
0,
0,
0,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
1,
1
] |
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