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values | subtask_type stringclasses 7
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values | cluster_id stringclasses 42
values | language stringclasses 1
value | split stringclasses 1
value | question stringlengths 148 1.41k | answer stringlengths 718 10.8k | claim_ids listlengths 0 8 | paper_ids listlengths 1 5 | evidence_span_ids listlengths 0 7 | association_ids listlengths 0 4 | hypothesis_ids listlengths 0 4 | record_json stringlengths 4.37k 33.7k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
QA:7ad23b3bd84382d5bee4a2f4 | QAG:df63967e87ab14646216c4e0 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "CM from IL-17RB KD PSCs (CM KD) increased the growth of pancreatic cancer cells to the same extent as CM from IL-17RB VEC KD PSCs (CM VEC KD)"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:053ffd7bb6e6ca17b0bc3071","quotes":["CM from IL-17RB KD PSCs (CM KD) increased the growth of pancreatic cancer ce... | [
"CLM:053ffd7bb6e6ca17b0bc3071",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC8611647"
] | [
"SPAN:f83def7854a6fb94081c2ff3"
] | [] | [] | {"qa_id":"QA:7ad23b3bd84382d5bee4a2f4","qa_group_id":"QAG:df63967e87ab14646216c4e0","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"CM from IL-17RB KD PSCs (CM KD) increased the growth of pancreatic... |
QA:7c606ec10a4ba02325bebce5 | QAG:2861d7b777387abe572e5525 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Our results suggested that SCD high CAF promoted the drug resistance against GEM and DDP in PDAC, regardless of the SCD expression level in tumor cells themselves"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:d8085d6c67fc27660b82eca3","quotes":["Our results suggested that SCD high CAF promoted the drug resistance against... | [
"CLM:d8085d6c67fc27660b82eca3",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC9794976"
] | [
"SPAN:89bd07938f677d88c13ad8f7"
] | [] | [] | {"qa_id":"QA:7c606ec10a4ba02325bebce5","qa_group_id":"QAG:2861d7b777387abe572e5525","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Our results suggested that SCD high CAF promoted the drug resistan... |
QA:7cb116f8be93196641a3f895 | QAG:93c3e3479ad9fcd44f186db4 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "(C) PDAC cells received the indicated concentrations of ERKi (24 h) and evaluated using immunoblot analyses for the indicated proteins"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact s... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:2101b34d5e2af604364403e8","quotes":["Statistical significance was determined via dispersion corrected, moderated ... | [
"CLM:2101b34d5e2af604364403e8",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC8665414"
] | [
"SPAN:0a899525e347a7007e947188"
] | [] | [] | {"qa_id":"QA:7cb116f8be93196641a3f895","qa_group_id":"QAG:93c3e3479ad9fcd44f186db4","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"(C) PDAC cells received the indicated concentrations of ERKi (24 h... |
QA:7d50cf8989a164d12806f6a8 | QAG:d00cedc810c8431ac89515fc | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "When the tumor volumes reached ∼100 mm 3 , mice bearing PDAC xenografts were randomly divided into 6 groups and received following treatments, respectively, including i) vehicle; ii) 25 mg/kg ECON; iii) 25 mg/kg CQ; iv) 1 mg/kg trametinib; v) 25 mg/kg ECON + 1 mg/kg tr... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:b45155a92a8814642ae08073","quotes":["When the tumor volumes reached ∼100 mm 3 , mice bearing PDAC xenografts were... | [
"CLM:b45155a92a8814642ae08073",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC9293665"
] | [
"SPAN:2328e80edfe459f0afb10601"
] | [] | [] | {"qa_id":"QA:7d50cf8989a164d12806f6a8","qa_group_id":"QAG:d00cedc810c8431ac89515fc","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"When the tumor volumes reached ∼100 mm 3 , mice bearing PDAC xenog... |
QA:7d62fc28df65aae69d8ebe10 | QAG:17fd54f5db99c1461866afa0 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "These authors concluded that RAGE signaling strongly led to ERK activation in their mouse model of pancreatic cancer"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:7eef162dd0914b611db066ba","quotes":["These authors concluded that RAGE signaling strongly contributed to ERK acti... | [
"CLM:7eef162dd0914b611db066ba",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC8067004"
] | [
"SPAN:76693026748a216b217a6b40"
] | [] | [] | {"qa_id":"QA:7d62fc28df65aae69d8ebe10","qa_group_id":"QAG:17fd54f5db99c1461866afa0","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"These authors concluded that RAGE signaling strongly led to ERK ac... |
QA:7ecdb87a0d12e78a8b8a87b3 | QAG:ab51ddb3c683fb618bd2f62c | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "We have shown therapeutic delivery of miR-198 using LGA-PEI as a delivery system led to repression of VCP-associated autophagy and sensitized PDAC to gemcitabine treatment, reducing tumor burden and metastatic spread in PDAC mouse models"? Return the original wording w... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:121de99ea16e4cdf37c555c8","quotes":["We have shown therapeutic delivery of miR-198 using LGA-PEI as a delivery sy... | [
"CLM:121de99ea16e4cdf37c555c8",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC10457905"
] | [
"SPAN:19b2aef33c0210b32f779897"
] | [] | [] | {"qa_id":"QA:7ecdb87a0d12e78a8b8a87b3","qa_group_id":"QAG:ab51ddb3c683fb618bd2f62c","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"We have shown therapeutic delivery of miR-198 using LGA-PEI as a d... |
QA:7f441f170a07ce814c07823c | QAG:5ad83d189dd284a1e4e4fc2d | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Importantly, we observed that CQ significantly rescued cell proliferation inhibited by AXP-3019 in both PANC-1 and MIA PaCa-2 cell lines ( Figure 6 c,d), indicating that the induction of autophagy constitutes a fundamental prerequisite to powerfully induce PDAC cell de... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification","cross_paper_provenance"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:34fe77ea0f1d3337192b1a23","quotes":["Importantly, we observed that CQ significantly resc... | [
"CLM:34fe77ea0f1d3337192b1a23",
"CLM:13e0fc49df43845a164b6cd9",
"CLM:708ae613bd9b219428a3fb5d"
] | [
"PMCID:PMC9264795",
"PMCID:PMC9513735"
] | [
"SPAN:6bce490da9af6629c76192a2",
"SPAN:8b24eb48a5c9dd11defb01ae"
] | [
"ASC2:47a0980838129c3a2da8005c"
] | [
"HYP:DCH:d48c71837b56b8d99414db83"
] | {"qa_id":"QA:7f441f170a07ce814c07823c","qa_group_id":"QAG:5ad83d189dd284a1e4e4fc2d","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Importantly, we observed that CQ significantly rescued cell prolif... |
QA:7f55e0bff1bede384727e2e4 | QAG:5ca7fcfd2d47845df9995307 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "However, the stroma does not generally support tumor development—the complete depletion of the stroma led to the progression of pancreatic cancer"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:92867a66924a166fb4c31d39","quotes":["However, the stroma does not generally support tumor development—the complet... | [
"CLM:92867a66924a166fb4c31d39",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC8611647"
] | [
"SPAN:bd6c50a529f44ba04a24f316"
] | [] | [] | {"qa_id":"QA:7f55e0bff1bede384727e2e4","qa_group_id":"QAG:5ca7fcfd2d47845df9995307","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"However, the stroma does not generally support tumor development—t... |
QA:7f96ead3d69f088918fef4d7 | QAG:eae03235a291539eb2716cff | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "The results showed that chaperoning of the SCD-high CAFs improved the drug resistance of pancreatic cancer cells against gemcitabine and cisplatin, while the administration of SCD inhibitors neutralized the protective effect"? Return the original wording with paper, Cl... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:711556e3596e0d16cfc9d5f2","quotes":["The results showed that chaperoning of the SCD-high CAFs significantly impro... | [
"CLM:711556e3596e0d16cfc9d5f2",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC9794976"
] | [
"SPAN:539e1834ad4abdb50504ed44"
] | [] | [] | {"qa_id":"QA:7f96ead3d69f088918fef4d7","qa_group_id":"QAG:eae03235a291539eb2716cff","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"The results showed that chaperoning of the SCD-high CAFs improved ... |
QA:7fcbdd6d57e4aa19a9a11989 | QAG:e1a74302c1f6e49c9a48749b | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Western blot analysis demonstrated that OBP-702 increased the expression of p53, E1A, and cleaved PARP in all human PDAC cells, whereas OBP-301 increased the expression of E1A ( Figures 4 A and 4B)"? Return the original wording with paper, Claim, and Evidence Span refe... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:962b2c09548fa08f71c571af","quotes":["Western blot analysis demonstrated that OBP-702 increased the expression of ... | [
"CLM:962b2c09548fa08f71c571af",
"CLM:053ffd7bb6e6ca17b0bc3071"
] | [
"PMCID:PMC9513735"
] | [
"SPAN:78ef5fb0c505c8cbdbe2486b"
] | [] | [] | {"qa_id":"QA:7fcbdd6d57e4aa19a9a11989","qa_group_id":"QAG:e1a74302c1f6e49c9a48749b","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Western blot analysis demonstrated that OBP-702 increased the expr... |
QA:80b0088295d1672626df02f8 | QAG:bc212d8c00e3276b5dcba456 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "( A, B ) SNIPER-11 increased gemcitabine induced Panc-1 or GR2000 cell apoptosis"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage with paper, Claim, and Evidence Span... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:98906d28ccf45fb59cc129ea","quotes":["Fig. 5 SNIPER-11 enhanced the efficacy of gemcitabine in PDAC. ( A, B ) SNIP... | [
"CLM:98906d28ccf45fb59cc129ea",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC8903155"
] | [
"SPAN:87d4ca4bacfbf44ffb591cfc"
] | [] | [] | {"qa_id":"QA:80b0088295d1672626df02f8","qa_group_id":"QAG:bc212d8c00e3276b5dcba456","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"( A, B ) SNIPER-11 increased gemcitabine induced Panc-1 or GR2000 ... |
QA:812e3e33f545a0ef85012203 | QAG:2f8f01bcf071e2347ef38985 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "( F ) increased IL-17B expression in pancreatic cancer tissue compared to adjacent non-tumor tissue (normal) tissue"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage w... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:3492eeb1dab9f5a6e7e2d105","quotes":["Fibroblast ( n = 5540) vs. CAF ( n = 5769; p = 0.004 t -test), tumor cells i... | [
"CLM:3492eeb1dab9f5a6e7e2d105",
"CLM:0254266c32c41ab5d504f862"
] | [
"PMCID:PMC8611647"
] | [
"SPAN:e5a2729c2f3d590cd29bffd4"
] | [] | [] | {"qa_id":"QA:812e3e33f545a0ef85012203","qa_group_id":"QAG:2f8f01bcf071e2347ef38985","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"( F ) increased IL-17B expression in pancreatic cancer tissue comp... |
QA:82143330bbfacf57b012a5c8 | QAG:9851726f542fd48c1079ec98 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Long-term ERK inhibition in KRAS-mutant pancreatic cancer was associated with MYC degradation and senescence-like growth suppression"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact sup... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:2cb89a247fb618e36e098a6a","quotes":["Long-term ERK inhibition in KRAS-mutant pancreatic cancer is associated with... | [
"CLM:2cb89a247fb618e36e098a6a",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC8665414"
] | [
"SPAN:c18a2c1565d0e9a07033fb2a"
] | [] | [] | {"qa_id":"QA:82143330bbfacf57b012a5c8","qa_group_id":"QAG:9851726f542fd48c1079ec98","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Long-term ERK inhibition in KRAS-mutant pancreatic cancer was asso... |
QA:83aa3d87954501083a48e687 | QAG:33dc7c7181300abb75d17e54 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "CAFs are the most abundant cells in PDAC and multiple studies have investigated how the tumor-stroma crosstalk led to tumor progression, invasion, metastasis and chemoresistance"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:88abe6897665f00761cca5dd","quotes":["CAFs are the most abundant cells in PDAC and multiple studies have investiga... | [
"CLM:88abe6897665f00761cca5dd",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC8997741"
] | [
"SPAN:ce8d54befbeda75328c09b8b"
] | [] | [] | {"qa_id":"QA:83aa3d87954501083a48e687","qa_group_id":"QAG:33dc7c7181300abb75d17e54","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"CAFs are the most abundant cells in PDAC and multiple studies have... |
QA:8450ff81b68c5a98eacfdc16 | QAG:93a8021cf42d38ccf535151b | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "However, as CHK1i increased ERK activity, which is a driver of MYC protein stability, loss of MYC was not expected in KRAS mutant PDAC"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact s... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:b63ba26ae2b62c1d860ec026","quotes":["However, as CHK1i elevated ERK activity, which is a driver of MYC protein st... | [
"CLM:b63ba26ae2b62c1d860ec026",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC8665414"
] | [
"SPAN:a34bc675c57563144b02976a"
] | [] | [] | {"qa_id":"QA:8450ff81b68c5a98eacfdc16","qa_group_id":"QAG:93a8021cf42d38ccf535151b","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"However, as CHK1i increased ERK activity, which is a driver of MYC... |
QA:84df6eee06b5f41ce0a0e01b | QAG:1d78e3e022f2c7791f3d8c62 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Furthermore, feeding a high-fat, high-calorie diet to LSL-KRAS G12D (KC) mice carrying a pancreas-specific oncogenic KRAS mutation prominently increased the incidence of PDAC"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated pro... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:47e9104cdc30af1ee58d8e0f","quotes":["Furthermore, feeding a high-fat, high-calorie diet to LSL-KRAS G12D (KC) mic... | [
"CLM:47e9104cdc30af1ee58d8e0f",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC10664664"
] | [
"SPAN:96a96f6c9d4bad191c7c29e2"
] | [] | [] | {"qa_id":"QA:84df6eee06b5f41ce0a0e01b","qa_group_id":"QAG:1d78e3e022f2c7791f3d8c62","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Furthermore, feeding a high-fat, high-calorie diet to LSL-KRAS G12... |
QA:8558228ccd63cf6c2f12faaa | QAG:6c24f0083d8519e957a0ed5f | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Most recently, a randomized Phase II study demonstrated that the addition of hydroxychloroquine to neoadjuvant gemcitabine and nab-paclitaxel chemotherapy in patients with resectable PDAC resulted in inhibition of autophagy and resulting improved response, indicating t... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:3ee6cfbaa80921ac69ad6762","quotes":["Most recently, a randomized Phase II study demonstrated that the addition of... | [
"CLM:3ee6cfbaa80921ac69ad6762",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC10457905"
] | [
"SPAN:c144e7b4fe32fe93679f313e"
] | [] | [] | {"qa_id":"QA:8558228ccd63cf6c2f12faaa","qa_group_id":"QAG:6c24f0083d8519e957a0ed5f","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Most recently, a randomized Phase II study demonstrated that the a... |
QA:8aa857c2f5120a7df87d5537 | QAG:dd9e4eebca5c0f31ad651ac7 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "To investigate the potential involvement of polyamines in the combination promoted ferroptosis, we added exogenous polyamines (spermine and spermidine) to PDAC cells treated with gemcitabine and cisplatin"? Return the original wording with paper, Claim, and Evidence Sp... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:a347b820fcb0a0a85c7bf8b4","quotes":["To investigate the potential involvement\nof polyamines in the combination-i... | [
"CLM:a347b820fcb0a0a85c7bf8b4",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC12974020"
] | [
"SPAN:424c57a85311d30da1024a6a"
] | [] | [] | {"qa_id":"QA:8aa857c2f5120a7df87d5537","qa_group_id":"QAG:dd9e4eebca5c0f31ad651ac7","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"To investigate the potential involvement of polyamines in the comb... |
QA:8ae4424814fd8d6245d29a68 | QAG:14dd256352e86a001aa7bf80 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "T o overcome these limitations, recent efforts led to the creation of sirpiglenastat (DRP-104), a pro-drug version of DON that circumvents the toxicities of DON while retaining the covalent and irreversible properties of DON16– 19. Early-phase clinical trials are exami... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:86d02a39e64213f4e1144431","quotes":["T o overcome these limitations, recent efforts\nled to the creation of sirpi... | [
"CLM:86d02a39e64213f4e1144431",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC10824664"
] | [
"SPAN:4072e53924c2f30aeb2b2a81"
] | [] | [] | {"qa_id":"QA:8ae4424814fd8d6245d29a68","qa_group_id":"QAG:14dd256352e86a001aa7bf80","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"T o overcome these limitations, recent efforts led to the creation... |
QA:8afe4a23c8144d4ac54138c3 | QAG:5e9ace73ae74ee8c898db07b | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "As loss of autophagy in PDAC also led to drop in cysteine levels ( 12 ), we analyzed whether supplementation of N -acetyl cysteine (NAC) in autophagy-inhibited cells could rescue effects on SDHB expression"? Return the original wording with paper, Claim, and Evidence S... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:9217aa8cfb743f431e5b8967","quotes":["As loss of autophagy in PDAC also leads to drop in cysteine levels ( 12 ), w... | [
"CLM:9217aa8cfb743f431e5b8967",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC10115412"
] | [
"SPAN:41f81f6b61f109bd19977a0b"
] | [] | [] | {"qa_id":"QA:8afe4a23c8144d4ac54138c3","qa_group_id":"QAG:5e9ace73ae74ee8c898db07b","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"As loss of autophagy in PDAC also led to drop in cysteine levels (... |
QA:8b0f31b639a8d4c4848de20c | QAG:8a5ba3dd74cc5a37766a9814 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "This elevation could be decreased by 3-MA or 4-PBA but reinforced by CQ treatment ( Fig. 6 M–O), echoing the results from flow cytometric analysis ( Fig. 6 P)"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirem... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:be73c6afeee01e5e1dfafa11","quotes":["This elevation could be attenuated by 3-MA or 4-PBA but reinforced by CQ tre... | [
"CLM:be73c6afeee01e5e1dfafa11",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC9293665"
] | [
"SPAN:07a20f4eb4ca5059278fbfdf",
"SPAN:7972a321fb124d3e875fd0b2"
] | [] | [] | {"qa_id":"QA:8b0f31b639a8d4c4848de20c","qa_group_id":"QAG:8a5ba3dd74cc5a37766a9814","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"This elevation could be decreased by 3-MA or 4-PBA but reinforced ... |
QA:8b6381a3ff652f9881e6f061 | QAG:dd9e27cc2caf0eddf639eee3 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Results A higher expression of CRABP-II was found in relapsing PDAC tissue and was associated with poor prognosis"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage wit... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:fb0dcadbd5399755d9073cc8","quotes":["Results A higher expression of CRABP-II was found in relapsing PDAC tissue a... | [
"CLM:fb0dcadbd5399755d9073cc8",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC8903155"
] | [
"SPAN:d350528d142063f0dd9a35ce"
] | [] | [] | {"qa_id":"QA:8b6381a3ff652f9881e6f061","qa_group_id":"QAG:dd9e27cc2caf0eddf639eee3","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Results A higher expression of CRABP-II was found in relapsing PDA... |
QA:8bc63d36c4b0b3bc1b7bf8c5 | QAG:bafeba7d777e5fd4f0ab6b00 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "4 Genetic inhibition of SAT1 abrogates the ferroptosis‑inducing effect of gemcitabine plus cisplatin in PDAC To investigate the role of SAT1 in gemcitabine and cisplatin promoted ferroptosis, we used specific siRNAs to knockdown SAT1 expression"? Return the original wo... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification","cross_paper_provenance"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:1e5ed5ed7ca30f1f5b5033fe","quotes":["3.4 Genetic inhibition of SAT1 abrogates\nthe ferr... | [
"CLM:1e5ed5ed7ca30f1f5b5033fe",
"CLM:03219ae941a2b333b95944b3",
"CLM:301d0f75305d7d91afd8cd27"
] | [
"PMCID:PMC12974020",
"PMCID:PMC8903155"
] | [
"SPAN:97a98bb4248459b681404b84",
"SPAN:1fb9e0dfea1cfc926ba3ed6e"
] | [
"ASC2:4b86ca8cb0ba159795b4554c"
] | [
"HYP:DCH:3972f7564df80ab510c0f8e2"
] | {"qa_id":"QA:8bc63d36c4b0b3bc1b7bf8c5","qa_group_id":"QAG:bafeba7d777e5fd4f0ab6b00","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"4 Genetic inhibition of SAT1 abrogates the ferroptosis‑inducing ef... |
QA:8be26992dfe6c67b07dfce55 | QAG:6b7bb2b8c5787f149fb2ccaa | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "We also investigated the role of NURR1 in drug resistance and observed that treatment of pancreatic cancer cells with gemcitabine led to induction of NURR1 ( Fig. 1 )"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:8621151fb165d0ffeb99cac5","quotes":["We also investigated the role of NURR1 in drug resistance and observed that ... | [
"CLM:8621151fb165d0ffeb99cac5",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC9109828"
] | [
"SPAN:dc9e1a721292d4910a7b2f0e"
] | [] | [] | {"qa_id":"QA:8be26992dfe6c67b07dfce55","qa_group_id":"QAG:6b7bb2b8c5787f149fb2ccaa","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"We also investigated the role of NURR1 in drug resistance and obse... |
QA:8c7775bf8ea9454c93bc6f05 | QAG:1b8e140c56cec5c94b9ecc69 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Because poor differentiation was associated with poor outcome and increased chemo-resistance , these observations indicate that elevated CRABP-II expression may contribute to PDAC drug-resistance and increased risk of recurrence"? Return the original wording with paper... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:d4e4fde5e99ca9ba03b9358b","quotes":["Because poor differentiation is associated with poor outcome and increased c... | [
"CLM:d4e4fde5e99ca9ba03b9358b",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC8903155"
] | [
"SPAN:b838573d7a49dc3f4fa7df2e"
] | [] | [] | {"qa_id":"QA:8c7775bf8ea9454c93bc6f05","qa_group_id":"QAG:1b8e140c56cec5c94b9ecc69","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Because poor differentiation was associated with poor outcome and ... |
QA:8ca615f8ffcb4c4626ccc130 | QAG:c72435de07ddce5dafc74dc8 | provenance_qa | paper_evidence_availability | provenance_qa | G020 | en | train | Does the current traceable evidence dataset contain a usable Claim and exact source span for paper PMCID:PMC9298440? Explicitly abstain if it does not.
Integrated provenance requirements: report evidence availability or insufficiency without inventing missing full text. Keep each subtask answer separately identifiable... | {"answer_type":"integrated_provenance","embedded_answer_types":["paper_evidence_availability"],"exact_evidence_retrieval":null,"limited_evidence_retrieval":null,"paper_evidence_availability":{"answer_type":"explicit_evidence_abstention","paper_id":"PMCID:PMC9298440","verdict":"no_released_traceable_claim","reason":"No ... | [] | [
"PMCID:PMC9298440"
] | [] | [] | [] | {"qa_id":"QA:8ca615f8ffcb4c4626ccc130","qa_group_id":"QAG:c72435de07ddce5dafc74dc8","qa_family":"provenance_qa","subtask_type":"paper_evidence_availability","language":"en","cluster_id":"G020","question":"Does the current traceable evidence dataset contain a usable Claim and exact source span for paper PMCID:PMC9298440... |
QA:90015dc3b8f3e717288d86c9 | QAG:3989963ab2cf78cf623000e3 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "reported that the starvation-induced TFEB nuclear translocation in HeLa cells was inhibited by ERK/MAPK2-mediated phosphorylation , which was also observed in PDAC models that inhibition of RAS–RAF–MEK–ERK/MAPK signaling pathway resulted in increased autophagic flux"? ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:78d8e2f9158fe0cd38fbcf55","quotes":["In addition, Settembre et al. reported that the starvation-induced TFEB nucl... | [
"CLM:78d8e2f9158fe0cd38fbcf55",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC9614569"
] | [
"SPAN:0ee16eccd4a04822f4f809b5"
] | [] | [] | {"qa_id":"QA:90015dc3b8f3e717288d86c9","qa_group_id":"QAG:3989963ab2cf78cf623000e3","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"reported that the starvation-induced TFEB nuclear translocation in... |
QA:9032ea4dae12208cc90f1a07 | QAG:8b0d4b2be381a970915536ce | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "LIPH downregulation in PDAC cells inhibited colony formation and proliferation"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage with paper, Claim, and Evidence Span r... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:ad95de64658e2c2c73c6ac0e","quotes":["LIPH downregulation in PDAC cells inhibited colony formation and proliferati... | [
"CLM:ad95de64658e2c2c73c6ac0e",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC10664664"
] | [
"SPAN:21131b8075e1003d579a2939"
] | [] | [] | {"qa_id":"QA:9032ea4dae12208cc90f1a07","qa_group_id":"QAG:8b0d4b2be381a970915536ce","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"LIPH downregulation in PDAC cells inhibited colony formation and p... |
QA:90f98100e4463def08a3ec76 | QAG:ec7ef87718dcb8c48257912e | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "reported that the starvation-induced TFEB nuclear translocation in HeLa cells was suppressed by ERK/MAPK2-mediated phosphorylation , which was also observed in PDAC models that inhibition of RAS–RAF–MEK–ERK/MAPK signaling pathway resulted in increased autophagic flux"?... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification","cross_paper_provenance"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:4d5ddf661d031de106ea9e17","quotes":["In addition, Settembre et al. reported that the sta... | [
"CLM:4d5ddf661d031de106ea9e17",
"CLM:03219ae941a2b333b95944b3",
"CLM:742da0110e017dc842d63d72"
] | [
"PMCID:PMC9614569",
"PMCID:PMC8665414"
] | [
"SPAN:0ee16eccd4a04822f4f809b5",
"SPAN:6fd7c11e49f1de6acbe57f01"
] | [
"ASC2:966cf3ce94b9653882bdd68a"
] | [
"HYP:DCH:613121d4ca0d5cb70477e776"
] | {"qa_id":"QA:90f98100e4463def08a3ec76","qa_group_id":"QAG:ec7ef87718dcb8c48257912e","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"reported that the starvation-induced TFEB nuclear translocation in... |
QA:92bf1bbdd1837083c4737832 | QAG:aeb11a5949fcc4179165ffa5 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "PDA is a prime example of a tumor that develops chemoresistance and to investigate the possible relationship between chemotherapeutic drugs and NURR1 expression pancreatic cancer cells were treated with gemcitabine and analysis by immunoblot and immunofluorescence show... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:0b37c68891bec8045dae723d","quotes":["PDA is a prime example of a tumor that develops chemoresistance and to inves... | [
"CLM:0b37c68891bec8045dae723d",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC9109828"
] | [
"SPAN:c185282c503327a5907995f4"
] | [] | [] | {"qa_id":"QA:92bf1bbdd1837083c4737832","qa_group_id":"QAG:aeb11a5949fcc4179165ffa5","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"PDA is a prime example of a tumor that develops chemoresistance an... |
QA:941282637c7aa70f9980cfc5 | QAG:c39953359b0afbe889a858dd | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Additional file 5: Figure S5 LIPH-LPA-LPAR axis increased PDAC glycolysis and viability by activating hypoxia and Hippo pathways"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact support... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:308b10c8b4ec9464a4049dc0","quotes":["D Oxygen consumption rate (OCR) detected by Seahorse analyzer (O: oligomycin... | [
"CLM:308b10c8b4ec9464a4049dc0",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC10664664"
] | [
"SPAN:3f774e2c98592d3ec873eeb1"
] | [] | [] | {"qa_id":"QA:941282637c7aa70f9980cfc5","qa_group_id":"QAG:c39953359b0afbe889a858dd","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Additional file 5: Figure S5 LIPH-LPA-LPAR axis increased PDAC gly... |
QA:96e2002d11f6c6bc04bfd6f1 | QAG:91927e65d528d86df3d101d4 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Conclusions In summary, our findings suggested the gemcitabine and cisplatin combination therapy promoted ferroptosis in a GSH-independent manner in PDAC"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements:... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:b6373b2baed9a34eb4eb9cd4","quotes":["Conclusions In summary, our findings suggested the gemcitabine and cisplatin... | [
"CLM:b6373b2baed9a34eb4eb9cd4",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC12974020"
] | [
"SPAN:4ca005272f58c3360de0c88a"
] | [] | [] | {"qa_id":"QA:96e2002d11f6c6bc04bfd6f1","qa_group_id":"QAG:91927e65d528d86df3d101d4","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Conclusions In summary, our findings suggested the gemcitabine and... |
QA:970780051b15426b0c68acf3 | QAG:15ad467f8de95adbd8d39e37 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Although the Hippo pathway has received a great deal of attention, additional activation mechanisms for YAP/TAZ signaling have been identified in PDAC, including the PI3K/AKT/mTORC1 pathway 70 , 74"? Return the original wording with paper, Claim, and Evidence Span refe... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:e4e55b5d07a5944df9d0423a","quotes":["Although the Hippo pathway has received a great deal of attention, additiona... | [
"CLM:e4e55b5d07a5944df9d0423a",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC8901637"
] | [
"SPAN:227b3150422a18a62f133272"
] | [] | [] | {"qa_id":"QA:970780051b15426b0c68acf3","qa_group_id":"QAG:15ad467f8de95adbd8d39e37","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Although the Hippo pathway has received a great deal of attention,... |
QA:97815be13143697269687faa | QAG:d730404ca47be664db2523ee | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "These findings elucidate that the ATF3/AKT axis is required for ECON promoted autophagy"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage with paper, Claim, and Eviden... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:fcafa2941509201c1ead077e","quotes":["These findings elucidate that the ATF3/AKT axis is required for ECON-induced... | [
"CLM:fcafa2941509201c1ead077e",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC9293665"
] | [
"SPAN:36af4a6ad40aabad401758a1",
"SPAN:c7931a159d6acbc8b34f6f67"
] | [] | [] | {"qa_id":"QA:97815be13143697269687faa","qa_group_id":"QAG:d730404ca47be664db2523ee","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"These findings elucidate that the ATF3/AKT axis is required for EC... |
QA:9811decbcd4b1c684598fd38 | QAG:2de1c70a62d5bdc24fa4d146 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "The activated pancreatic stellate cells of patients with pancreatic cancer express high levels of autophagy markers, extracellular matrix (ECM) proteins and interleukin-6 (IL-6), and the greater production of these proteins was associated with worse prognosis, shorter ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:0c27354d7b6b89a38805175d","quotes":["The activated pancreatic stellate cells of patients with pancreatic cancer e... | [
"CLM:0c27354d7b6b89a38805175d",
"CLM:0254266c32c41ab5d504f862"
] | [
"PMCID:PMC8419034"
] | [
"SPAN:b730dea3876dac8d8e19b054"
] | [] | [] | {"qa_id":"QA:9811decbcd4b1c684598fd38","qa_group_id":"QAG:2de1c70a62d5bdc24fa4d146","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"The activated pancreatic stellate cells of patients with pancreati... |
QA:98f0f95469d5f0196ce92ff7 | QAG:199e0908a51816f3969ed131 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Results PI3K-C2γ expression was reduced in about 30% of PDAC cases and was associated with an aggressive phenotype"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage wi... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:5a3bc0c85bbdde2b058bc065","quotes":["Results PI3K-C2γ expression was reduced in about 30% of PDAC cases and was a... | [
"CLM:5a3bc0c85bbdde2b058bc065",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC9872233"
] | [
"SPAN:54029aa0fe39064007fc6b1a"
] | [] | [] | {"qa_id":"QA:98f0f95469d5f0196ce92ff7","qa_group_id":"QAG:199e0908a51816f3969ed131","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Results PI3K-C2γ expression was reduced in about 30% of PDAC cases... |
QA:99379bfb95de3d173c6c0c61 | QAG:433c43d052cbf3ad137a430b | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "To assess whether the autophagic flux status impacts LDs turnover in pancreatic cancer cells, we inhibited autophagy with HCQ, an inhibitor of autophagosome–lysosomal fusion and measured the abundance of LDs by staining of HPDEK cells with BODIPY 493/503. We found that... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:9067ed2d530fef981b56a1e3","quotes":["To assess whether the autophagic flux status impacts LDs turnover in pancrea... | [
"CLM:9067ed2d530fef981b56a1e3",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC8742413"
] | [
"SPAN:1ac0537c7cb0485092e56051"
] | [] | [] | {"qa_id":"QA:99379bfb95de3d173c6c0c61","qa_group_id":"QAG:433c43d052cbf3ad137a430b","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"To assess whether the autophagic flux status impacts LDs turnover ... |
QA:999a9e288d870e4d378f24ca | QAG:b623bf41351ef5889d61a238 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "We provided in vitro evidence that, beside slowing proliferation, butyrate increased gemcitabine effectiveness against two human pancreatic cancer cell lines, mainly inducing apoptosis"? Return the original wording with paper, Claim, and Evidence Span references.
Inte... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:6792c9623ec74dde7c4e0fa3","quotes":["We provided in vitro evidence that, beside slowing proliferation, butyrate e... | [
"CLM:6792c9623ec74dde7c4e0fa3",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMID:35617803"
] | [
"SPAN:f5f7c0105fb0a5e88cda16ff"
] | [] | [] | {"qa_id":"QA:999a9e288d870e4d378f24ca","qa_group_id":"QAG:b623bf41351ef5889d61a238","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"We provided in vitro evidence that, beside slowing proliferation, ... |
QA:9b6023a163fc4ea856168181 | QAG:aad05a1839b411dd638d4c7e | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Taken together, these data indicated that LPA produced by LIPH promoted pancreatic cancer cell proliferation by enhancing glycolysis in vitro and in vivo"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements:... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:a4f8bc2cd0a3c42ce5040ae3","quotes":["Taken together, these data indicated that LPA produced by LIPH promoted panc... | [
"CLM:a4f8bc2cd0a3c42ce5040ae3",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC10664664"
] | [
"SPAN:94c0ef9f41e71b1be7153c8f"
] | [] | [] | {"qa_id":"QA:9b6023a163fc4ea856168181","qa_group_id":"QAG:aad05a1839b411dd638d4c7e","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Taken together, these data indicated that LPA produced by LIPH pro... |
QA:9ba4304bd4b054acec672daf | QAG:1d284218c4a926f949a6a94e | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "We first dem- onstrated that DON treatment led to a significant decrease in cellular proliferation across several PDAC tumors (Fig. 1b and Extended Data Fig. 1a–h)"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance req... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:45d4d87c64aeaa2a102bd429","quotes":["We first dem-\nonstrated that DON treatment led to a significant decrease in... | [
"CLM:45d4d87c64aeaa2a102bd429",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC10824664"
] | [
"SPAN:0e408fc9948a09772428ac61"
] | [] | [] | {"qa_id":"QA:9ba4304bd4b054acec672daf","qa_group_id":"QAG:1d284218c4a926f949a6a94e","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"We first dem- onstrated that DON treatment led to a significant de... |
QA:9c0415257ef04e8f68a2aad6 | QAG:9eabd9ef9d3223c384983794 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "GPR55 expression negatively correlates with survival in patients with glioblastoma, breast cancer, and PDAC 10 , 14 , 15 , and genetic ablation of Gpr55 prolonged survival in the KPC transgenic mouse model of PDAC 15"? Return the original wording with paper, Claim, and... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:565e222a491ec372124de9bc","quotes":["GPR55 expression negatively correlates with survival in patients with gliobl... | [
"CLM:565e222a491ec372124de9bc",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC8901637"
] | [
"SPAN:e110f22ef9adacff2f90bb55"
] | [] | [] | {"qa_id":"QA:9c0415257ef04e8f68a2aad6","qa_group_id":"QAG:9eabd9ef9d3223c384983794","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"GPR55 expression negatively correlates with survival in patients w... |
QA:9d5f86488972248834c7d5a5 | QAG:0744be126d9f0d741ac6a571 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "The p53-mediated induction of apoptosis and autophagy in human and murine PDAC cells observed in the present study was associated with OBP-702 promoted release of ATP and HMGB1 ( Figures 4 and 5 )"? Return the original wording with paper, Claim, and Evidence Span refer... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:12478f776b3d0a095eddaaaa","quotes":["The p53-mediated induction of apoptosis and autophagy in human and murine PD... | [
"CLM:12478f776b3d0a095eddaaaa",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC9513735"
] | [
"SPAN:d3e31e6c3e28f670fa506068"
] | [] | [] | {"qa_id":"QA:9d5f86488972248834c7d5a5","qa_group_id":"QAG:0744be126d9f0d741ac6a571","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"The p53-mediated induction of apoptosis and autophagy in human and... |
QA:9e57128fac24643133c95ae8 | QAG:c7b691f5e664e7fb1827387a | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "7 G, when the tumor volumes achieved ∼100 mm 3 , mice bearing PDAC xenografts were randomly divided into 6 groups and received the following treatments: i) vehicle; ii) 25 mg/kg ECON; iii) 25 mg/kg CQ; iv) 1 mg/kg trametinib; v) 25 mg/kg ECON+1 mg/kg trametinib; and vi... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:7c03f8166b6355b0b90c0299","quotes":["In Fig. 7 G, when the tumor volumes reached ∼100 mm 3 , mice bearing PDAC xe... | [
"CLM:7c03f8166b6355b0b90c0299",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC9293665"
] | [
"SPAN:cccca1ef19ba27740ef6807f"
] | [] | [] | {"qa_id":"QA:9e57128fac24643133c95ae8","qa_group_id":"QAG:c7b691f5e664e7fb1827387a","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"7 G, when the tumor volumes achieved ∼100 mm 3 , mice bearing PDAC... |
QA:9f262a6c6df83c735c176d3d | QAG:f991fc2e3fcf1c16fb1e9eac | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Figure 6 To further address whether ER stress inhibited PDAC cell growth by inducing apoptosis, we conducted immunoblot and immunohistochemical analyses and found that the expression of apoptosis markers was significantly elevated in response to ECON ( Fig. 6 K and L)"... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:4ba04c968bf6271bf5ebf1a7","quotes":["Figure 6 To further address whether ER stress inhibited PDAC cell growth by ... | [
"CLM:4ba04c968bf6271bf5ebf1a7",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC9293665"
] | [
"SPAN:7972a321fb124d3e875fd0b2"
] | [] | [] | {"qa_id":"QA:9f262a6c6df83c735c176d3d","qa_group_id":"QAG:f991fc2e3fcf1c16fb1e9eac","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Figure 6 To further address whether ER stress inhibited PDAC cell ... |
QA:9f8a712a1c6ab36ab8cb4bcc | QAG:c8afaa494d9c8bf529ee059d | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "FASN is a downstream target of SREBP-1c and was associated with PDAC cancer stemness and drug-resistance"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage with paper, ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:bb6d9d84aba2ee133bb66804","quotes":["FASN is a downstream target of SREBP-1c and has been associated with PDAC ca... | [
"CLM:bb6d9d84aba2ee133bb66804",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC8903155"
] | [
"SPAN:0f651a28e4f688f0b6b47f52"
] | [] | [] | {"qa_id":"QA:9f8a712a1c6ab36ab8cb4bcc","qa_group_id":"QAG:c8afaa494d9c8bf529ee059d","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"FASN is a downstream target of SREBP-1c and was associated with PD... |
QA:9fa59c063f9ec00edd7e4329 | QAG:f333fb849fa6d66f4419865f | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Bioinformatics analyses of pancreatic cancer public datasets showed that glycogen phosphorylase L (PYGL) expression is increased in quasimesenchymal PDAC (QM-PDAC) and positively associated with EMT"? Return the original wording with paper, Claim, and Evidence Span ref... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:35e81c515a8810949b1c4a55","quotes":["Bioinformatics analyses of pancreatic cancer public datasets showed that gly... | [
"CLM:35e81c515a8810949b1c4a55",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC10092766"
] | [
"SPAN:036cf6233068c90e59616b95"
] | [] | [] | {"qa_id":"QA:9fa59c063f9ec00edd7e4329","qa_group_id":"QAG:f333fb849fa6d66f4419865f","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Bioinformatics analyses of pancreatic cancer public datasets showe... |
QA:a0b259eeef9b423e571c7332 | QAG:1ca6e093a6b8bbf231d0b0bc | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "This shift is associated with hypoxia-driven formation of lipid droplets containing triacylglycerols and cholesterol esters 54 , with concomitant decrease in free fatty acid concentration in plasma 55 and tumor tissues 56 stemming from decreased expression of lipolytic... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:59e5bc240a19b724d6bb5026","quotes":["This shift is associated with hypoxia-driven formation of lipid droplets con... | [
"CLM:59e5bc240a19b724d6bb5026",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC8901637"
] | [
"SPAN:60f83799e786c68b6ce9b73a",
"SPAN:92faab7f7851ce07d26a404e"
] | [] | [] | {"qa_id":"QA:a0b259eeef9b423e571c7332","qa_group_id":"QAG:1ca6e093a6b8bbf231d0b0bc","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"This shift is associated with hypoxia-driven formation of lipid dr... |
QA:a0dbc4bf145e3e01ba86c347 | QAG:8975e3b649e63c6a277dd3b3 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Ad-p53-treated human PDAC cells showed more than 60% of zombie dye-unlabeled cells maintaining membrane integrity, in which the proportion of cell surface calreticulin+ cells was not increased ( Figures S8 and S9 )"? Return the original wording with paper, Claim, and E... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:654c597852729d21d87ae7f1","quotes":["Ad-p53-treated human PDAC cells showed more than 60% of zombie dye-unlabeled... | [
"CLM:654c597852729d21d87ae7f1",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC9513735"
] | [
"SPAN:e021fbb04bbe4f5db45f792e"
] | [] | [] | {"qa_id":"QA:a0dbc4bf145e3e01ba86c347","qa_group_id":"QAG:8975e3b649e63c6a277dd3b3","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Ad-p53-treated human PDAC cells showed more than 60% of zombie dye... |
QA:a181f985ad050fa912fec5dc | QAG:85cfaf48b74e5ac9cda7992b | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Using a preclinical mouse model of PDAC and a monoclonal antibody (IgG 2A11) as a RAGE inhibitor, we demonstrate that RAGE inhibition concurrent with gemcitabine treatment increased the cytotoxic effect of gemcitabine"? Return the original wording with paper, Claim, an... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:b7aeba308c095dfe240fe49a","quotes":["Using a preclinical mouse model of PDAC and a monoclonal antibody (IgG 2A11)... | [
"CLM:b7aeba308c095dfe240fe49a",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC8067004"
] | [
"SPAN:023f9773ebb2b707c9815982"
] | [] | [] | {"qa_id":"QA:a181f985ad050fa912fec5dc","qa_group_id":"QAG:85cfaf48b74e5ac9cda7992b","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Using a preclinical mouse model of PDAC and a monoclonal antibody ... |
QA:a190096ec451378e4c984c0c | QAG:4692ad47e8c8a7cf29e2cb88 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Palbociclib promoted autophagy and senescence in gastric cancer cells"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage with paper, Claim, and Evidence Span references... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:aa6d0035cd8d5f8790f4b24f","quotes":["Palbociclib-induced autophagy and senescence in gastric cancer cells."],"cit... | [
"CLM:aa6d0035cd8d5f8790f4b24f",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC7447818"
] | [
"SPAN:5c4147011e1ec50ffed84952"
] | [] | [] | {"qa_id":"QA:a190096ec451378e4c984c0c","qa_group_id":"QAG:4692ad47e8c8a7cf29e2cb88","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Palbociclib promoted autophagy and senescence in gastric cancer ce... |
QA:a1ad7e73954aae278407232a | QAG:6595954919ad0bb3656b1652 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Together, these results suggust that autophagy involves in the BNIP3 promoted pancreatic cancer cell migration and proliferation under hypoxia"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:ecf047b1581bedf9a365b452","quotes":["Together, these results suggust that autophagy involves in the BNIP3-induced... | [
"CLM:ecf047b1581bedf9a365b452",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC9614569"
] | [
"SPAN:13e6ab5fd22c64dd2b7f4dc2"
] | [] | [] | {"qa_id":"QA:a1ad7e73954aae278407232a","qa_group_id":"QAG:6595954919ad0bb3656b1652","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Together, these results suggust that autophagy involves in the BNI... |
QA:a239d849e7c8a9fb398ae8ba | QAG:ddab81dda4e3faa9cc33051b | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Actually, this massive increase in autophagosomes promoted by ECON has gone far beyond the scope of what PDAC cells could withstand, possibly moving the controlled, pro-survival autophagy into an uncontrolled, pro-death mechanism in which lysosomal scavenging pathways ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:4c6369e4898b8ffb10c9ca0f","quotes":["Actually, this massive increase in autophagosomes induced by ECON has gone f... | [
"CLM:4c6369e4898b8ffb10c9ca0f",
"CLM:053ffd7bb6e6ca17b0bc3071"
] | [
"PMCID:PMC9293665"
] | [
"SPAN:b387a272d481d1a761a0ee9d"
] | [] | [] | {"qa_id":"QA:a239d849e7c8a9fb398ae8ba","qa_group_id":"QAG:ddab81dda4e3faa9cc33051b","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Actually, this massive increase in autophagosomes promoted by ECON... |
QA:a23f115f82ec7f1fa598cef6 | QAG:f032e9e5b2efc5869297c685 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Kaplan–Meier analysis revealed that high LIPH expression in cancer tissues was associated with poor prognosis in patients with PDAC (Fig. 1 C, D; Additional file 1 : Fig. S1I)"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated pr... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:aa7a623142aa4de09503d60d","quotes":["Kaplan–Meier analysis revealed that high LIPH expression in cancer tissues w... | [
"CLM:aa7a623142aa4de09503d60d",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC10664664"
] | [
"SPAN:735d096fc113350aa6a8d100"
] | [] | [] | {"qa_id":"QA:a23f115f82ec7f1fa598cef6","qa_group_id":"QAG:f032e9e5b2efc5869297c685","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Kaplan–Meier analysis revealed that high LIPH expression in cancer... |
QA:a2f9c97054859a1c8b666a20 | QAG:80e2f1c9dee0c7b66148287b | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "This demonstrates that NURR1 expression is increased during chemotherapeutic treatment and the mechanisms of gemcitabine induction of NURR1 and GEM – C-DIM12 interactions are unknown and are currently being investigated"? Return the original wording with paper, Claim, ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:a18b0b785dbce757f62841f3","quotes":["This demonstrates that NURR1 expression is increased during chemotherapeutic... | [
"CLM:a18b0b785dbce757f62841f3",
"CLM:0254266c32c41ab5d504f862"
] | [
"PMCID:PMC9109828"
] | [
"SPAN:6376bdeab194204dfe11407a",
"SPAN:c185282c503327a5907995f4"
] | [] | [] | {"qa_id":"QA:a2f9c97054859a1c8b666a20","qa_group_id":"QAG:80e2f1c9dee0c7b66148287b","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"This demonstrates that NURR1 expression is increased during chemot... |
QA:a3042683ca88e59f67e92b84 | QAG:6def333dc7b3ab549a315194 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "These findings suggest that the ferroptosis pathway may be involved in cell death promoted by combined gemcitabine and cisplatin chemotherapy in PDAC"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: ret... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:7f460af8faa2a9ddb7b1cb39","quotes":["These findings\nsuggest that the ferroptosis pathway may be involved in\ncel... | [
"CLM:7f460af8faa2a9ddb7b1cb39",
"CLM:053ffd7bb6e6ca17b0bc3071"
] | [
"PMCID:PMC12974020"
] | [
"SPAN:fe5de6e150b38e9534b26e23"
] | [] | [] | {"qa_id":"QA:a3042683ca88e59f67e92b84","qa_group_id":"QAG:6def333dc7b3ab549a315194","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"These findings suggest that the ferroptosis pathway may be involve... |
QA:a5997fbd09330de6874fa2e4 | QAG:42b5ced4e8e45ade3371f901 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Interestingly, MMRi62 promoted ferroptosis occurs in PDAC cell lines harboring either KRAS and TP53 double mutations or single TP53 mutation"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the e... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:bca5ca4e22a21f8da33b5204","quotes":["Interestingly, MMRi62-induced ferroptosis occurs in PDAC cell lines harborin... | [
"CLM:bca5ca4e22a21f8da33b5204",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC10258866"
] | [
"SPAN:ae080c3cfee23d7fa15aa6e6"
] | [] | [] | {"qa_id":"QA:a5997fbd09330de6874fa2e4","qa_group_id":"QAG:42b5ced4e8e45ade3371f901","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Interestingly, MMRi62 promoted ferroptosis occurs in PDAC cell lin... |
QA:a748ec80c45934f08476c89b | QAG:ca5f589cc7714e7360c7feb7 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Chemosensitivity promoted by Down-Regulation of MicroRNA-21 in Gemcitabine-Resistant Pancreatic Cancer Cells by Indole-3-Carbinol"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact suppor... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:2c37d94ae1d2440f718f73c8","quotes":["26. Paik W.H., Kim H.R., Park J.K., Song B.J., Lee S.H., Hwang J.-H. Chemose... | [
"CLM:2c37d94ae1d2440f718f73c8",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC10457905"
] | [
"SPAN:80366782102b0df6072f185c"
] | [] | [] | {"qa_id":"QA:a748ec80c45934f08476c89b","qa_group_id":"QAG:ca5f589cc7714e7360c7feb7","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Chemosensitivity promoted by Down-Regulation of MicroRNA-21 in Gem... |
QA:a76bbc0d0557f6330936017d | QAG:87d8e0af744f3227a4ee1403 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Irinotecan delivery by lipid-coated mesoporous silica nanoparticles shows improved efficacy and safety over liposomes for pancreatic cancer"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the ex... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:b576ecbe98ad48875bf5a947","quotes":["26. Liu X, et al. Irinotecan delivery by lipid-coated mesoporous silica nano... | [
"CLM:b576ecbe98ad48875bf5a947",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC7447818"
] | [
"SPAN:9156f319c409f6c2a107187d"
] | [] | [] | {"qa_id":"QA:a76bbc0d0557f6330936017d","qa_group_id":"QAG:87d8e0af744f3227a4ee1403","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Irinotecan delivery by lipid-coated mesoporous silica nanoparticle... |
QA:a84eaf0e2c96bac2b6dd0021 | QAG:b978ab4893907d8b19b0a102 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Figure 2 shows that these compounds did not affect GAPDH activity in normal fibroblasts ( Figure 2 a), likely for their differential membrane permeability as compared to cancer cells, while AXP-3009 and AXP-3019 inhibited GAPDH in PANC-1 ( Figure 2 b) and MIA PaCa-2 ( ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:dd7f1f275704cf3726b5df4d","quotes":["Figure 2 shows that these compounds did not affect GAPDH activity in normal ... | [
"CLM:dd7f1f275704cf3726b5df4d",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC9264795"
] | [
"SPAN:fa4b21c01b905c139d1b4091"
] | [] | [] | {"qa_id":"QA:a84eaf0e2c96bac2b6dd0021","qa_group_id":"QAG:b978ab4893907d8b19b0a102","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Figure 2 shows that these compounds did not affect GAPDH activity ... |
QA:a9358f429c38f71ab13c4242 | QAG:4c81dfc5953243ed3c68e61e | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "( H ) Extracellular vesicles (EVs) from human pancreatic cancer cell lines promoted the expression of IL-17RB in PSCs"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:e5d24a80cb57219989d6bff6","quotes":["ELISA of specimens of in-house PDAC patients ( n = 7; p = 0.0263; Wilcoxon m... | [
"CLM:e5d24a80cb57219989d6bff6",
"CLM:0254266c32c41ab5d504f862"
] | [
"PMCID:PMC8611647"
] | [
"SPAN:66d39fc94809dbbab35f921d"
] | [] | [] | {"qa_id":"QA:a9358f429c38f71ab13c4242","qa_group_id":"QAG:4c81dfc5953243ed3c68e61e","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"( H ) Extracellular vesicles (EVs) from human pancreatic cancer ce... |
QA:a9a75eec341d528147c1ba1e | QAG:8493dc97f8ab2de77e848712 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Our identification of CHK1i as a strategy to enhance the anti-tumor activity of ERK inhibitor treatment contrasts with a previous study of non-PDAC cancers, in which ERK MAPK signaling was associated with CHK1i sensitivity and MEK inhibition drove CHK1i resistance ( Le... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:742da0110e017dc842d63d72","quotes":["Our identification of CHK1i as a strategy to enhance the anti-tumor activity... | [
"CLM:742da0110e017dc842d63d72",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC8665414"
] | [
"SPAN:6fd7c11e49f1de6acbe57f01"
] | [] | [] | {"qa_id":"QA:a9a75eec341d528147c1ba1e","qa_group_id":"QAG:8493dc97f8ab2de77e848712","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Our identification of CHK1i as a strategy to enhance the anti-tumo... |
QA:aa06d4deaa6df311fbaed299 | QAG:7af63397ecc80ee80e1bc06d | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "These results have led to several clinical trials, which have had variable responses for reasons that are not abundantly clear"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supportin... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:2d5d160936883c624898763c","quotes":["These results have led to several clinical trials, which have had variable r... | [
"CLM:2d5d160936883c624898763c",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC10457905"
] | [
"SPAN:0a90eb7aa2fd3c612ef1329d",
"SPAN:1b8bf67bcd9286cc06260bd9"
] | [] | [] | {"qa_id":"QA:aa06d4deaa6df311fbaed299","qa_group_id":"QAG:7af63397ecc80ee80e1bc06d","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"These results have led to several clinical trials, which have had ... |
QA:aa50a895d9a1b2480a548c9c | QAG:3f6a7157580678c36640e62e | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Expression levels of glucose transporters and rate-limiting enzymes regulate the rate of glycolytic flux, which is dramatically promoted in PDAC cells even in the presence of oxygen and normal mitochondrial functionality"? Return the original wording with paper, Claim,... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:055df3f6edeb73512ff71e28","quotes":["Expression levels of glucose transporters and rate-limiting enzymes regulate... | [
"CLM:055df3f6edeb73512ff71e28",
"CLM:053ffd7bb6e6ca17b0bc3071"
] | [
"PMCID:PMC9264795"
] | [
"SPAN:d75a0a2853e5394a77e6828a"
] | [] | [] | {"qa_id":"QA:aa50a895d9a1b2480a548c9c","qa_group_id":"QAG:3f6a7157580678c36640e62e","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Expression levels of glucose transporters and rate-limiting enzyme... |
QA:aa8a5bb4929a3e41fa6d733a | QAG:fc131c8c26c7cb83ba282eb6 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Collectively, the data from our study reveal that the hypoxia/PYGL/glycolysis promoted EMT promotes PDAC metastasis, which establishes the rational for targeting hypoxia/PYGL/glycolysis/EMT signaling pathway against PDAC"? Return the original wording with paper, Claim,... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:2b873bc58f4bd8eb7d173dd9","quotes":["Collectively, the data from our study reveal that the hypoxia/PYGL/glycolysi... | [
"CLM:2b873bc58f4bd8eb7d173dd9",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC10092766"
] | [
"SPAN:3c6b65f1a9ababab5af03032"
] | [] | [] | {"qa_id":"QA:aa8a5bb4929a3e41fa6d733a","qa_group_id":"QAG:fc131c8c26c7cb83ba282eb6","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Collectively, the data from our study reveal that the hypoxia/PYGL... |
QA:aaa457ed268c3b1edf7fe574 | QAG:7c6f104ac77c7fca22d774f9 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "defined a gene signature consisting of LYRM1 , KNTC1 , IGF2BP2 and CDC6 that was associated with the progression and prognosis of PDAC"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact s... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:dcb44f611a5c61d662b511e6","quotes":["Yan et al. defined a gene signature consisting of LYRM1 , KNTC1 , IGF2BP2 an... | [
"CLM:dcb44f611a5c61d662b511e6",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC8997486"
] | [
"SPAN:01fc87558098b1011276a3c7"
] | [] | [] | {"qa_id":"QA:aaa457ed268c3b1edf7fe574","qa_group_id":"QAG:7c6f104ac77c7fca22d774f9","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"defined a gene signature consisting of LYRM1 , KNTC1 , IGF2BP2 and... |
QA:ad94f953a7def767f110e427 | QAG:58ea993ba1b7977c9a96976d | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "We previously reported that miR-198 administration in pancreatic cancer cells led to a significant reduction in tumor burden and metastases"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the ex... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:9c366d2fbfc66bffb7ff86e6","quotes":["We previously reported that miR-198 administration in pancreatic cancer cell... | [
"CLM:9c366d2fbfc66bffb7ff86e6",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC10457905"
] | [
"SPAN:77d9b19ccac693b5edb1ea28"
] | [] | [] | {"qa_id":"QA:ad94f953a7def767f110e427","qa_group_id":"QAG:58ea993ba1b7977c9a96976d","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"We previously reported that miR-198 administration in pancreatic c... |
QA:afa11c5cff7d4200bf53d42c | QAG:9fef05b84224b76bff4a72ec | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Consistent with a previous study supporting a role for ATF3 as a negative regulator in the AKT pathway in prostate carcinoma 25 , it was found that ECON promoted ATF3 overexpression was inversely associated with the level of p-AKT by histological analyses ( Fig. 4 ), s... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification","cross_paper_provenance"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:2e46de0c7b80a9d5c0006a8d","quotes":["Consistent with a previous study supporting a role ... | [
"CLM:2e46de0c7b80a9d5c0006a8d",
"CLM:03219ae941a2b333b95944b3",
"CLM:0a01e893027b3e621e4f91bf"
] | [
"PMCID:PMC9293665",
"PMCID:PMC10621596"
] | [
"SPAN:5b3e8374bba7228f0ad6e1d2",
"SPAN:c12b2be3f0cefe5d09c80a1c"
] | [
"ASC2:588d31a27f0a0a23d42677f2"
] | [
"HYP:DCH:b4f673b85e1cc29cc7b38634"
] | {"qa_id":"QA:afa11c5cff7d4200bf53d42c","qa_group_id":"QAG:9fef05b84224b76bff4a72ec","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Consistent with a previous study supporting a role for ATF3 as a n... |
QA:b075d817ee59dcd60f55e24c | QAG:9f067ae06e200d5ad17d604e | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "4 Genetic inhibition of SAT1 attenuates the ferroptosis promoted by the co-treatment of gemcitabine and cisplatin in PDAC cells"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporti... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:5646a6c3e62f6fb7c8ca635a","quotes":["5% percent of the chromatin was used as input\ncontrol and the rest was incu... | [
"CLM:5646a6c3e62f6fb7c8ca635a",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC12974020"
] | [
"SPAN:b6fabd93ef8e19428d75257b"
] | [] | [] | {"qa_id":"QA:b075d817ee59dcd60f55e24c","qa_group_id":"QAG:9f067ae06e200d5ad17d604e","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"4 Genetic inhibition of SAT1 attenuates the ferroptosis promoted b... |
QA:b0b281b9976be04c7b281b3c | QAG:d52102725b7624570f0efe3d | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "the time curve revealed that the volume of the tumours increased considerably in the controls (vehicle) and in mice treated with AXP-3009, while they substantially did not grow in mice treated with AXP-3019, even after a long period following mice inoculation with PDAC... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:8894a6b391693375026d99ce","quotes":["Remarkably, examination of the tumour volume vs. the time curve revealed tha... | [
"CLM:8894a6b391693375026d99ce",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC9264795"
] | [
"SPAN:9ad465ca0184b651673c94b8"
] | [] | [] | {"qa_id":"QA:b0b281b9976be04c7b281b3c","qa_group_id":"QAG:d52102725b7624570f0efe3d","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"the time curve revealed that the volume of the tumours increased c... |
QA:b0be6cd9cdb5fb923a280af1 | QAG:683dcc8c8eb0be7315c6192b | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Pancreatic ductal adenocarcinoma (PDAC), generally characterized by proliferation of desmoplastic stromal cells and metabolic dysfunction, is considered one of the most aggressive cancers and was associated with high rates of metastasis and mortality 1 , 2"? Return the... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:5902ee427e6dc48a39534a0b","quotes":["Pancreatic ductal adenocarcinoma (PDAC), generally characterized by prolifer... | [
"CLM:5902ee427e6dc48a39534a0b",
"CLM:0b37c68891bec8045dae723d"
] | [
"PMCID:PMC8419034"
] | [
"SPAN:e4e8518696d7b52d85878194"
] | [] | [] | {"qa_id":"QA:b0be6cd9cdb5fb923a280af1","qa_group_id":"QAG:683dcc8c8eb0be7315c6192b","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Pancreatic ductal adenocarcinoma (PDAC), generally characterized b... |
QA:b0f2145d73fd42de4bf5983e | QAG:4bddecc9c863814a2af20de9 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "3 Activation of SAT1 by gemcitabine plus cisplatin induces ferroptosis in PDAC To elucidate the molecular mechanism underlying the combinative treatment promoted ferroptosis, we conducted a bioinformatics analysis of the Gene Expression Omnibus (GEO) database (as descr... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:9fba1c82278095af5ec806f2","quotes":["3.3 Activation of SAT1 by gemcitabine plus cisplatin\ninduces ferroptosis i... | [
"CLM:9fba1c82278095af5ec806f2",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC12974020"
] | [
"SPAN:286b9e4f65d76264933897f7"
] | [] | [] | {"qa_id":"QA:b0f2145d73fd42de4bf5983e","qa_group_id":"QAG:4bddecc9c863814a2af20de9","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"3 Activation of SAT1 by gemcitabine plus cisplatin induces ferropt... |
QA:b1455fdd5b4131d417e1d316 | QAG:4ab5bcd838bd4eb267b0fd0b | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "The number of tumor-infiltrating CD8+ T cells was increased in combination therapy ( Figure 6 ), suggesting that OBP-702 has therapeutic potential to promote the anti-tumor immune response against PDAC tumors"? Return the original wording with paper, Claim, and Evidenc... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:b4b5401ed26edc91d5745e3f","quotes":["The number of tumor-infiltrating CD8+ T cells was significantly increased in... | [
"CLM:b4b5401ed26edc91d5745e3f",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC9513735"
] | [
"SPAN:f00a2def3b779199bdbb4230"
] | [] | [] | {"qa_id":"QA:b1455fdd5b4131d417e1d316","qa_group_id":"QAG:4ab5bcd838bd4eb267b0fd0b","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"The number of tumor-infiltrating CD8+ T cells was increased in com... |
QA:b314f3289b19015dfaf1f12c | QAG:cf081cbc8724c60b07521fcb | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "reported that the starvation-induced TFEB nuclear translocation in HeLa cells was suppressed by ERK/MAPK2-mediated phosphorylation , which was also observed in PDAC models that inhibition of RAS–RAF–MEK–ERK/MAPK signaling pathway led to increased autophagic flux"? Retu... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:d1ceb8ddcffe3c3e11ba2403","quotes":["In addition, Settembre et al. reported that the starvation-induced TFEB nucl... | [
"CLM:d1ceb8ddcffe3c3e11ba2403",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC9614569"
] | [
"SPAN:0ee16eccd4a04822f4f809b5"
] | [] | [] | {"qa_id":"QA:b314f3289b19015dfaf1f12c","qa_group_id":"QAG:cf081cbc8724c60b07521fcb","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"reported that the starvation-induced TFEB nuclear translocation in... |
QA:b5d362d898087fd0f21d8fd0 | QAG:e099ba5aa143dd43ead593f8 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "In addition, we showed that SNIPER-11 treatment decreased liver metastasis in PDAC bearing mice, consistent with other reports that high cholesterol promotes PDAC metastasis and our previous finding that CRABP-II favored PDAC cell invasion and migration through upregul... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:b037fea2b55dbe5b1c0dea9d","quotes":["In addition, we showed that SNIPER-11 treatment reduced liver metastasis in ... | [
"CLM:b037fea2b55dbe5b1c0dea9d",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC8903155"
] | [
"SPAN:b6175b24dec494fbde5a5047"
] | [] | [] | {"qa_id":"QA:b5d362d898087fd0f21d8fd0","qa_group_id":"QAG:e099ba5aa143dd43ead593f8","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"In addition, we showed that SNIPER-11 treatment decreased liver me... |
QA:b64a072bb82fc575556a9716 | QAG:e76a00acdb2e9fd9d8bade4a | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "6 Negative regulation of Sp1 activates SAT1 in PDAC cells treated with gemcitabine and cisplatin Subsequently, we aims to evaluate the underlying mechanism by which the combination of gemcitabine and cisplatin activates SAT1 in PDAC"? Return the original wording with p... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:779cab8b8279ce6057dece16","quotes":["3.6 Negative regulation of Sp1 activates SAT1\nin PDAC cells treated with g... | [
"CLM:779cab8b8279ce6057dece16",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC12974020"
] | [
"SPAN:40f07706bd55338841875f68"
] | [] | [] | {"qa_id":"QA:b64a072bb82fc575556a9716","qa_group_id":"QAG:e76a00acdb2e9fd9d8bade4a","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"6 Negative regulation of Sp1 activates SAT1 in PDAC cells treated ... |
QA:b699e4ffe9607bfce6aefcb6 | QAG:5c21dea56f17cd37e8a9d98a | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Although KRAS drives the majority of PDAC cases (85–90%) and was associated with chemo-resistance , it has not been effectively targeted for PDAC patients"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:08b314c66aa0c778d3b2049b","quotes":["Although KRAS drives the majority of PDAC cases (85–90%) and is associated w... | [
"CLM:08b314c66aa0c778d3b2049b",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC8903155"
] | [
"SPAN:361ec5540e8563107594ca09"
] | [] | [] | {"qa_id":"QA:b699e4ffe9607bfce6aefcb6","qa_group_id":"QAG:5c21dea56f17cd37e8a9d98a","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Although KRAS drives the majority of PDAC cases (85–90%) and was a... |
QA:b828c2570f600614abd9535a | QAG:c62a63600c20b06530bca096 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "These results suggest that OBP-702-induced ICD in human PDAC cells was associated with p53-mediated induction of apoptosis and autophagy"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:d3f3e49c4fca684b7cc2a10e","quotes":["These results suggest that OBP-702-induced ICD in human PDAC cells is associ... | [
"CLM:d3f3e49c4fca684b7cc2a10e",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC9513735"
] | [
"SPAN:d30047e02ef77e2799b99770"
] | [] | [] | {"qa_id":"QA:b828c2570f600614abd9535a","qa_group_id":"QAG:c62a63600c20b06530bca096","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"These results suggest that OBP-702-induced ICD in human PDAC cells... |
QA:b8c84164335a0e0ce0351b80 | QAG:5412a05755b6fcab282782a7 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "( A, B ) SNIPER-11 increased gemcitabine promoted Panc-1 or GR2000 cell apoptosis"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage with paper, Claim, and Evidence Spa... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:c61ff005362bcc1d785e4a56","quotes":["Fig. 5 SNIPER-11 enhanced the efficacy of gemcitabine in PDAC. ( A, B ) SNIP... | [
"CLM:c61ff005362bcc1d785e4a56",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC8903155"
] | [
"SPAN:87d4ca4bacfbf44ffb591cfc"
] | [] | [] | {"qa_id":"QA:b8c84164335a0e0ce0351b80","qa_group_id":"QAG:5412a05755b6fcab282782a7","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"( A, B ) SNIPER-11 increased gemcitabine promoted Panc-1 or GR2000... |
QA:b8d8a07e8104b8500c447d0c | QAG:8e9acdc776283f0b630f4424 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "As autophagy is increased in PDAC, targeting the autophagic pathway is regarded as a promising strategy for cancer treatment"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:f5931ad2e5548016d09d5448","quotes":["As autophagy is elevated in PDAC, targeting the autophagic pathway is regard... | [
"CLM:f5931ad2e5548016d09d5448",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC10710504"
] | [
"SPAN:4efeebef512eb17ad5188cee"
] | [] | [] | {"qa_id":"QA:b8d8a07e8104b8500c447d0c","qa_group_id":"QAG:8e9acdc776283f0b630f4424","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"As autophagy is increased in PDAC, targeting the autophagic pathwa... |
QA:b8f08816260b30f99f96189c | QAG:2e09dd5047bf91d4e2e5cfbc | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "These results together indicated that BNIP3-mediated autophagy promoted the migration and proliferation of pancreatic cancer cells"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact suppo... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:b259e16e8ea4398ad0f9dec0","quotes":["These results together indicated that BNIP3-mediated autophagy promoted the ... | [
"CLM:b259e16e8ea4398ad0f9dec0",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC9614569"
] | [
"SPAN:3ab9fb572dca445e071c9081"
] | [] | [] | {"qa_id":"QA:b8f08816260b30f99f96189c","qa_group_id":"QAG:2e09dd5047bf91d4e2e5cfbc","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"These results together indicated that BNIP3-mediated autophagy pro... |
QA:bcd9feb44beba0e8f8ce5a4c | QAG:b7497674166e153a5d2ab5f0 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Supporting the potential therapeutic value of targeting CHK1 in PDAC, co-treatment with CHK1-selective inhibitors sensitized to gemcitabine and/or radiation in preclinical models ( Engelke et al., 2013 ; Morgan et al., 2010 ; Parsels et al., 2011 )"? Return the origina... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:4eb24d8024db11bf0f85187d","quotes":["Supporting the potential therapeutic value of targeting CHK1 in PDAC, co-tre... | [
"CLM:4eb24d8024db11bf0f85187d",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC8665414"
] | [
"SPAN:9f86f38fe6404513a2a3f042"
] | [] | [] | {"qa_id":"QA:bcd9feb44beba0e8f8ce5a4c","qa_group_id":"QAG:b7497674166e153a5d2ab5f0","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Supporting the potential therapeutic value of targeting CHK1 in PD... |
QA:bd2015789b1717dce69f0849 | QAG:e4d7d7039df41dad25aee760 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "The expression of ki67 was decreased in sh1-LIPH pancreatic cancer tumors, and the apoptosis marker, TUNEL, was significantly increased (Fig. 3 D, E)"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: ret... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:b148296c4b7f6bba14fd3d6f","quotes":["The expression of ki67 was decreased in sh1-LIPH pancreatic cancer tumors, a... | [
"CLM:b148296c4b7f6bba14fd3d6f",
"CLM:0254266c32c41ab5d504f862"
] | [
"PMCID:PMC10664664"
] | [
"SPAN:cedc9c4a12c535f6ed98d5d2"
] | [] | [] | {"qa_id":"QA:bd2015789b1717dce69f0849","qa_group_id":"QAG:e4d7d7039df41dad25aee760","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"The expression of ki67 was decreased in sh1-LIPH pancreatic cancer... |
QA:be983687836537c5f1e7c4e3 | QAG:256e904be9727664fd1961ea | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "As loss of autophagy in PDAC also leads to drop in cysteine levels ( 12 ), we analyzed whether supplementation of N -acetyl cysteine (NAC) in autophagy inhibited cells could rescue effects on SDHB expression"? Return the original wording with paper, Claim, and Evidence... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:1b35cc43553c9670254a4af6","quotes":["As loss of autophagy in PDAC also leads to drop in cysteine levels ( 12 ), w... | [
"CLM:1b35cc43553c9670254a4af6",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC10115412"
] | [
"SPAN:41f81f6b61f109bd19977a0b"
] | [] | [] | {"qa_id":"QA:be983687836537c5f1e7c4e3","qa_group_id":"QAG:256e904be9727664fd1961ea","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"As loss of autophagy in PDAC also leads to drop in cysteine levels... |
QA:bea6f8eb6fe6f567761e810d | QAG:77db6860e3739e46ae46880f | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Patients with higher CRABP-II expression levels have decreased overall survival and have shortened median survival from 22.03 months (low expression) to 18.93 months (high expression) (Fig. 1 a)"? Return the original wording with paper, Claim, and Evidence Span referen... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:9de20fc929d926673ac7248d","quotes":["Patients with higher CRABP-II expression levels have significantly reduced o... | [
"CLM:9de20fc929d926673ac7248d",
"CLM:0254266c32c41ab5d504f862"
] | [
"PMCID:PMC8903155"
] | [
"SPAN:2c53bbe7c0f426b13d816f21",
"SPAN:978afefd0ae56c1970969104"
] | [] | [] | {"qa_id":"QA:bea6f8eb6fe6f567761e810d","qa_group_id":"QAG:77db6860e3739e46ae46880f","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Patients with higher CRABP-II expression levels have decreased ove... |
QA:c20d30e10ea07abbcfaefd9e | QAG:28a3f3dbeeca0d6c2bc34c69 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "( c ) gbcxMRS predicted poor prognostic PDAC subtypes with high efficiency. ( d , e ) The enrichment score of infiltration immune cells in gbcxMRS subgroups. ( f , g ) The relationship between crucial metabolic signatures and immune signatures in the ( f ) E-MTAB-6134 ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:7b8de2cd9c3f81fc3c8b226e","quotes":["Figure 7 GbcxMRS predicted PDAC subtypes and influenced the tumor microenvir... | [
"CLM:7b8de2cd9c3f81fc3c8b226e",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC8997486"
] | [
"SPAN:d9e7d70165b2ce61fe5fa870"
] | [] | [] | {"qa_id":"QA:c20d30e10ea07abbcfaefd9e","qa_group_id":"QAG:28a3f3dbeeca0d6c2bc34c69","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"( c ) gbcxMRS predicted poor prognostic PDAC subtypes with high ef... |
QA:c33b1807aa073c088c524503 | QAG:56c76dfd1d9994472e6c2cee | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Additional file 4: Figure S4 LPA produced by LIPH promoted PDAC progression through enhancing glycolysis"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage with paper, ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:5ae5430b2a5b0ae3972539d0","quotes":["Scale bar = 100 µm. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001. ... | [
"CLM:5ae5430b2a5b0ae3972539d0",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC10664664"
] | [
"SPAN:c1921acf3d82d83f27ac3052"
] | [] | [] | {"qa_id":"QA:c33b1807aa073c088c524503","qa_group_id":"QAG:56c76dfd1d9994472e6c2cee","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Additional file 4: Figure S4 LPA produced by LIPH promoted PDAC pr... |
QA:c42abf7c363110be438d63dd | QAG:fb4b43b592e6836c9ff0b613 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Western blot analysis demonstrated that Ad-p53 induced apoptosis only in MIA PaCa-2 cells, although the expression of p53 was increased in all human PDAC cells ( Figure S10 )"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated pro... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:931b91bceeb218c3107d9168","quotes":["Western blot analysis demonstrated that Ad-p53 induced apoptosis only in MIA... | [
"CLM:931b91bceeb218c3107d9168",
"CLM:053ffd7bb6e6ca17b0bc3071"
] | [
"PMCID:PMC9513735"
] | [
"SPAN:8b24eb48a5c9dd11defb01ae"
] | [] | [] | {"qa_id":"QA:c42abf7c363110be438d63dd","qa_group_id":"QAG:fb4b43b592e6836c9ff0b613","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Western blot analysis demonstrated that Ad-p53 induced apoptosis o... |
QA:c7f7edd482ad1128714dfd7a | QAG:b6b081e826bbaa2d5e2a5777 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "In line with our data on GAPDH activity and cellular-proliferation inhibition, Figure 4 a shows that AXP-3009 and even more AXP-3019 treatments strongly decreased L-lactate secretion in PANC-1 and MIA PaCa-2 cell lines compared to untreated cells, while AXP-3018 did no... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:9c2a4400412c801740db3730","quotes":["Since cancer cells display increased uptake of glucose and aerobic glycolysi... | [
"CLM:9c2a4400412c801740db3730",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC9264795"
] | [
"SPAN:4916aeeda4838c157c299bbb"
] | [] | [] | {"qa_id":"QA:c7f7edd482ad1128714dfd7a","qa_group_id":"QAG:b6b081e826bbaa2d5e2a5777","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"In line with our data on GAPDH activity and cellular-proliferation... |
QA:c8902bb67f60baf06209c837 | QAG:61a6b71abac8fea750804b57 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "MMRi62-induced cell death in PDAC is characteristic of ferroptosis that was associated with increased autophagy, increased reactive oxygen species, and lysosomal degradation of NCOA4 and ferritin heavy chain (FTH1)"? Return the original wording with paper, Claim, and E... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:184e3a66760ff02ca5bb6dbf","quotes":["MMRi62-induced cell death in PDAC is characteristic of ferroptosis that is a... | [
"CLM:184e3a66760ff02ca5bb6dbf",
"CLM:053ffd7bb6e6ca17b0bc3071"
] | [
"PMCID:PMC10258866"
] | [
"SPAN:4104897a89e5caf32ce24b13"
] | [] | [] | {"qa_id":"QA:c8902bb67f60baf06209c837","qa_group_id":"QAG:61a6b71abac8fea750804b57","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"MMRi62-induced cell death in PDAC is characteristic of ferroptosis... |
QA:c89720d43ce0b1b74771ac9c | QAG:6b719263e9a8e7e120af52b1 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Electron microscopy images also demonstrate that pancreatic cancer cells were more sensitive to gemcitabine when treated in combination with C-DIM12 and this is evidenced by increased cell shrinkage and nuclear condensation in treated compared with control cells"? Retu... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:f36ec249aaa5dfe5f44db3c2","quotes":["Electron microscopy images also demonstrate that pancreatic cancer cells wer... | [
"CLM:f36ec249aaa5dfe5f44db3c2",
"CLM:0254266c32c41ab5d504f862"
] | [
"PMCID:PMC9109828"
] | [
"SPAN:d8aa356c154d89f14d500754"
] | [] | [] | {"qa_id":"QA:c89720d43ce0b1b74771ac9c","qa_group_id":"QAG:6b719263e9a8e7e120af52b1","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Electron microscopy images also demonstrate that pancreatic cancer... |
QA:c8fd7c72f69c02b91d7a1b76 | QAG:32a7306624fd920610ec1327 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "These results confirm that NURR1 exhibits prooncogenic-like activity in pancreatic cancer cells and this receptor also plays a role in gemcitabine promoted drug resistance ( Fig. 7E )"? Return the original wording with paper, Claim, and Evidence Span references.
Integ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:ca7f2f1e70e97a17a4fb3bc5","quotes":["These results confirm that NURR1 exhibits prooncogenic-like activity in panc... | [
"CLM:ca7f2f1e70e97a17a4fb3bc5",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC9109828"
] | [
"SPAN:2f1a3901c854876731c59c21"
] | [] | [] | {"qa_id":"QA:c8fd7c72f69c02b91d7a1b76","qa_group_id":"QAG:32a7306624fd920610ec1327","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"These results confirm that NURR1 exhibits prooncogenic-like activi... |
QA:cb295d8f6fd1da6413b97ebd | QAG:aac008b078298514ecea3640 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "These results confirmed the prooncogenic activity of NURR1 in pancreatic cancer cells as previously observed in other cancer cell lines ( 15 ) and demonstrated that the NURR1 antagonist C-DIM12 was an effective anticancer agent that inhibited NURR1 -mediated responses"... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:2344f7fe98dcb10347598658","quotes":["These results confirmed the prooncogenic activity of NURR1 in pancreatic can... | [
"CLM:2344f7fe98dcb10347598658",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC9109828"
] | [
"SPAN:07784e4c25940605d75de45f"
] | [] | [] | {"qa_id":"QA:cb295d8f6fd1da6413b97ebd","qa_group_id":"QAG:aac008b078298514ecea3640","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"These results confirmed the prooncogenic activity of NURR1 in panc... |
QA:cc1feba2ca2cebc84ea5a973 | QAG:1cb5e2c41aa5231e8785ee8e | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "This dysfunctional autophagy partially revealed the mechanisms underlying the correlation between ECON promoted cytotoxicity and autophagosome accumulation"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirement... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:92dc4b822bc57ef0bccce693","quotes":["This dysfunctional autophagy partially revealed the mechanisms underlying th... | [
"CLM:92dc4b822bc57ef0bccce693",
"CLM:00354d8cbec4dead29bb8637"
] | [
"PMCID:PMC9293665"
] | [
"SPAN:43cda4a55f4fabc32f8bc4dd",
"SPAN:ab2b0eeaf5a51d3a4717189a"
] | [] | [] | {"qa_id":"QA:cc1feba2ca2cebc84ea5a973","qa_group_id":"QAG:1cb5e2c41aa5231e8785ee8e","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"This dysfunctional autophagy partially revealed the mechanisms und... |
QA:cccf347fe8292512c8235f99 | QAG:316a0ca025ea51ddd69af368 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "We observed that gbcxMRS predicted poor OS and poor subtypes of PDAC as defined by previous studies"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage with paper, Claim... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:7c4378871398ded4b52f1610","quotes":["We observed that gbcxMRS predicted poor OS and poor subtypes of PDAC as defi... | [
"CLM:7c4378871398ded4b52f1610",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC8997486"
] | [
"SPAN:04807f42cfc2dedb97c0398f"
] | [] | [] | {"qa_id":"QA:cccf347fe8292512c8235f99","qa_group_id":"QAG:316a0ca025ea51ddd69af368","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"We observed that gbcxMRS predicted poor OS and poor subtypes of PD... |
QA:ccfd129364ac645d29a19f79 | QAG:8388a614ec3455d33a7c6e25 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "This pathway is of particular interest as incubation of PANC-1 cells with ( R , S ′)-MNF decreased the activating phosphorylation of AKT"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification","cross_paper_provenance","cross_paper_provenance"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:d4223c11dfe7292af121c738","quotes":["This pathway is of particu... | [
"CLM:d4223c11dfe7292af121c738",
"CLM:00354d8cbec4dead29bb8637",
"CLM:301d0f75305d7d91afd8cd27",
"CLM:9605ca7548acd6fa8199d2e3"
] | [
"PMCID:PMC8901637",
"PMCID:PMC8903155",
"PMCID:PMC9293665"
] | [
"SPAN:227b3150422a18a62f133272",
"SPAN:343f79bdf02724fdffd69202",
"SPAN:1fb9e0dfea1cfc926ba3ed6e",
"SPAN:b93263c9d29550804fe8ccdf"
] | [
"ASC2:473b119a82d252e3e82c2a05",
"ASC2:d0c978b4df5e00d9806bc2d9"
] | [
"HYP:DCH:78d6a4d201c3eca06f126669"
] | {"qa_id":"QA:ccfd129364ac645d29a19f79","qa_group_id":"QAG:8388a614ec3455d33a7c6e25","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"This pathway is of particular interest as incubation of PANC-1 cel... |
QA:cd00dde8f6a90b3db54d7812 | QAG:7ba38aa5d78dafe506187f32 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Heatmaps showing clonogenic assays ( D ) in PDAC cells and relative proliferation in a panel of PDAC cell lines after treatment with FAC in autophagy inhibited cells"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance r... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:5a6bc6a5e50512e6426e7657","quotes":["Heatmaps showing clonogenic assays ( D ) in PDAC cells and relative prolifer... | [
"CLM:5a6bc6a5e50512e6426e7657",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC10115412"
] | [
"SPAN:9ff4282cbcbc5e35ebc32f8c"
] | [] | [] | {"qa_id":"QA:cd00dde8f6a90b3db54d7812","qa_group_id":"QAG:7ba38aa5d78dafe506187f32","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Heatmaps showing clonogenic assays ( D ) in PDAC cells and relativ... |
QA:cd5e6b5cfefff63b96f82034 | QAG:23c01397956151b2c56a2a19 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "In addition, our signature accurately predicted the pure-basal-like subtype, another poor prognostic subtype of PDAC (AUC = 86.6%)"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact suppo... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:c073a366710e9c023b90c671","quotes":["In addition, our signature accurately predicted the pure-basal-like subtype,... | [
"CLM:c073a366710e9c023b90c671",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC8997486"
] | [
"SPAN:bfe892ce5ef8a1327e296f08"
] | [] | [] | {"qa_id":"QA:cd5e6b5cfefff63b96f82034","qa_group_id":"QAG:23c01397956151b2c56a2a19","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"In addition, our signature accurately predicted the pure-basal-lik... |
QA:cdf2a390cdb87c27f8bc767e | QAG:b524e1ef4c954815acd4aa35 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "The effect on CYR61 expression is of interest as increased CYR61 expression is associated with PDAC aggressiveness, drug resistance, and tumor-microenvironment interactions 75 – 77"? Return the original wording with paper, Claim, and Evidence Span references.
Integrat... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:93869261a40049c90f20e62b","quotes":["The effect on CYR61 expression is of interest as increased CYR61 expression ... | [
"CLM:93869261a40049c90f20e62b",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC8901637"
] | [
"SPAN:07891c616995d65b4c8e95bc"
] | [] | [] | {"qa_id":"QA:cdf2a390cdb87c27f8bc767e","qa_group_id":"QAG:b524e1ef4c954815acd4aa35","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"The effect on CYR61 expression is of interest as increased CYR61 e... |
QA:cfb315a8b65146e719c45df9 | QAG:230a068590fafda2717a4f49 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Figure 2 shows that these compounds did not improve GAPDH activity in normal fibroblasts ( Figure 2 a), likely for their differential membrane permeability as compared to cancer cells, while AXP-3009 and AXP-3019 significantly inhibited GAPDH in PANC-1 ( Figure 2 b) an... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:812a4ad391674477746542d4","quotes":["Figure 2 shows that these compounds did not affect GAPDH activity in normal ... | [
"CLM:812a4ad391674477746542d4",
"CLM:03219ae941a2b333b95944b3"
] | [
"PMCID:PMC9264795"
] | [
"SPAN:fa4b21c01b905c139d1b4091"
] | [] | [] | {"qa_id":"QA:cfb315a8b65146e719c45df9","qa_group_id":"QAG:230a068590fafda2717a4f49","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Figure 2 shows that these compounds did not improve GAPDH activity... |
QA:d231b1684630553871d3dd7b | QAG:75cc2c8407612f59cf4b3394 | provenance_qa | exact_evidence_retrieval | provenance_qa | G020 | en | train | Which exact source passage supports the statement "Autophagy and apoptosis are likely the main biological phenomena linked with the cell death promoted by treatment, as also evidenced by the absence of cytostatic phenomena and alteration of cell cycle phases after treatment of PDAC cells with GAPDH inhibitors (data not... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:da9f3ed64ea76a9838b4b18a","quotes":["Autophagy and apoptosis are likely the main biological phenomena linked with... | [
"CLM:da9f3ed64ea76a9838b4b18a",
"CLM:053ffd7bb6e6ca17b0bc3071"
] | [
"PMCID:PMC9264795"
] | [
"SPAN:5f624e56b189980bb88c63b8"
] | [] | [] | {"qa_id":"QA:d231b1684630553871d3dd7b","qa_group_id":"QAG:75cc2c8407612f59cf4b3394","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G020","question":"Which exact source passage supports the statement \"Autophagy and apoptosis are likely the main biological phenomena l... |
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