PDBID
stringlengths
4
4
Resolution
stringlengths
1
13
Year
int64
1.98k
2.02k
Ligand Name
stringlengths
1
7
Ligand Chain
stringclasses
53 values
Ligand Residue Number
stringlengths
1
9
Binding Affinity Measurement
stringclasses
4 values
Binding Affinity Sign
stringclasses
6 values
Binding Affinity Value
float64
0
500M
Binding Affinity Unit
stringclasses
6 values
Log Binding Affinity
float64
-14
2.97
Binding Affinity Source
stringclasses
3 values
Binding Affinity Annotation
stringlengths
6
72
Protein UniProtID
stringlengths
6
55
Protein UniProtName
stringlengths
2
575
Ligand SMILES
stringlengths
4
352
Ligand MW
float64
44
1.82k
Ligand LogP
float64
-23.01
13.7
Ligand TPSA
float64
0
786
Ligand NumRotBond
int64
0
59
Ligand NumHeavyAtoms
int64
3
120
Ligand NumHDon
int64
0
30
Ligand NumHAcc
int64
0
56
Ligand QED
float64
0.01
0.95
6oqy
2.23
2,019
N2J
A
601
ec50
=
600
nM
-6.221849
BindingDB
EC50=600nM
O00482
Nuclear receptor subfamily 5 group A member 2
C=C(c1ccccc1)[C@@]12CC[C@H](NS(N)(=O)=O)[C@@H]1CC(CCCCCC)=C2c1ccccc1
464.675
6.0858
72.19
10
33
2
2
0.417927
6or1
2.174
2,019
N27
A
601
ec50
=
13,000
nM
-4.886057
BindingDB
EC50=13000nM
O00482
Nuclear receptor subfamily 5 group A member 2
C=C(c1ccccc1)[C@@]12CC[C@H](NC(C)=O)[C@@H]1CC(CCCCCC)=C2c1ccccc1
427.632
7.4288
29.1
9
32
1
1
0.41424
6orr
2.25
2,019
N37
A
301
ki
=
500
pM
-9.30103
MOAD
Ki=500.0pM
P40261
NNMT protein
NC(=O)c1cccc(C#C[C@@H](CC[C@H]([NH3+])C(=O)[O-])C[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)c1
509.523
-2.6748
230.17
8
37
5
11
0.197539
6orr
2.25
2,019
N37
B
301
ki
=
500
pM
-9.30103
MOAD
Ki=500.0pM
P40261
NNMT protein
NC(=O)c1cccc(C#C[C@@H](CC[C@H]([NH3+])C(=O)[O-])C[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)c1
509.523
-2.6748
230.17
8
37
5
11
0.197539
6orr
2.25
2,019
N37
C
301
ki
=
500
pM
-9.30103
MOAD
Ki=500.0pM
P40261
NNMT protein
NC(=O)c1cccc(C#C[C@@H](CC[C@H]([NH3+])C(=O)[O-])C[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)c1
509.523
-2.6748
230.17
8
37
5
11
0.197539
6orr
2.25
2,019
N37
D
301
ki
=
500
pM
-9.30103
MOAD
Ki=500.0pM
P40261,P40261
NNMT protein,NNMT protein
NC(=O)c1cccc(C#C[C@@H](CC[C@H]([NH3+])C(=O)[O-])C[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)c1
509.523
-2.6748
230.17
8
37
5
11
0.197539
6os5
1.66
2,019
TRP
A
401
kd
=
4.4
uM
-5.356547
MOAD
Kd=4.4uM
A8M6W6
CymD prenyltransferase
[NH3+][C@@H](Cc1c[nH]c2ccccc12)C(=O)[O-]
204.229
-0.9292
83.56
3
15
2
2
0.67672
6os5
1.66
2,019
TRP
B
401
kd
=
4.4
uM
-5.356547
MOAD
Kd=4.4uM
A8M6W6
CymD prenyltransferase
[NH3+][C@@H](Cc1c[nH]c2ccccc12)C(=O)[O-]
204.229
-0.9292
83.56
3
15
2
2
0.67672
6os6
1.33
2,019
TRP
A
402
kd
=
1.1
uM
-5.958607
MOAD
Kd=1.1uM
A8M6W6
CymD prenyltransferase
[NH3+][C@@H](Cc1c[nH]c2ccccc12)C(=O)[O-]
204.229
-0.9292
83.56
3
15
2
2
0.67672
6os6
1.33
2,019
DST
A
401
kd
=
1
uM
-6
MOAD
Kd=1.0uM
A8M6W6
CymD prenyltransferase
CC(C)=CCS[P@](=O)([O-])OP(=O)([O-])[O-]
259.136
-0.0005
112.55
5
14
0
7
0.503912
6osp
2.21
2,020
N51
A
4001
ic50
=
190
nM
-6.721246
MOAD
ic50=190.0nM
P48426
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
C[NH+](C)C/C=C/C(=O)Nc1ccc(C(=O)Nc2cccc(Nc3cc(-c4c[nH]c5ccccc45)ncn3)c2)cc1
532.628
4.26
116.24
9
40
5
5
0.182017
6osp
2.21
2,020
N51
B
4001
ic50
=
190
nM
-6.721246
MOAD
ic50=190.0nM
P48426
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
C[NH+](C)C/C=C\C(=O)Nc1ccc(C(=O)Nc2cccc(Nc3cc(-c4c[nH]c5ccccc45)ncn3)c2)cc1
532.628
4.26
116.24
9
40
5
5
0.182017
6otg
1.5
2,019
4UY
B
201
ki
=
31.4
nM
-7.50307
MOAD
Ki=31.4nM
Q7SSI0,Q7SSI0
Protease,Protease
C[NH2+][C@H]1CO[C@@H]2OC[C@H](OC(=O)N[C@@H](Cc3ccccc3)[C@H](O)CN(CC(C)C)S(=O)(=O)c3ccc(OC)cc3)[C@@H]21
592.735
0.9734
140.24
13
41
3
8
0.312787
6ova
2.5
2,020
N9G
A
1200
ic50
=
1.1
nM
-8.958607
MOAD
ic50=1.1nM
P29597
Non-receptor tyrosine-protein kinase TYK2
CN(C)C(=O)c1ccc(Nc2cc(N3CC[C@@](C#N)(C4CC4)C3=O)ccn2)nc1
390.447
2.57868
102.22
5
29
1
6
0.841799
6ow2
1.7
2,019
NB4
P
302
ic50
=
3
nM
-8.522879
MOAD
ic50=3.0nM
Q8DP79
Peptide deformylase
Cc1nc(NNC(=O)[C@H](CC2CCCC2)CN(O)CO)c(F)c(N2CC[N@H+]3CCOC[C@@H]3C2)n1
482.581
-0.69158
127.52
9
34
5
9
0.229527
6ow7
1.45
2,019
N9Y
P
303
ic50
=
1
nM
-9
MOAD
ic50=1.0nM
Q8DP79
Peptide deformylase
O=CN(O)C[C@@H](CC1CCCC1)C(=O)N1NCCC[C@H]1C(=O)Nc1ccccn1
403.483
1.5598
114.87
8
29
3
6
0.344726
6ow7
1.45
2,019
N9Y
Q
303
ic50
=
1
nM
-9
MOAD
ic50=1.0nM
Q8DP79
Peptide deformylase
O=CN(O)C[C@@H](CC1CCCC1)C(=O)N1NCCC[C@H]1C(=O)Nc1ccccn1
403.483
1.5598
114.87
8
29
3
6
0.344726
6oyd
1.46
2,020
NKA
A
101
ic50
=
0.12
nM
-9.920819
MOAD
ic50=0.12nM
P12497
Protease
CC(C)CN(C[C@@H](O)[C@H](Cc1ccc(F)cc1)NC(=O)O[C@H]1[C@H]2CO[C@H]3OC[C@@H]1[C@H]3C2)S(=O)(=O)c1ccc2nc(NC(C)C)oc2c1
674.792
4.1397
152.46
13
47
3
10
0.241296
6oyr
1.54
2,020
NJY
A
101
ic50
=
0.29
nM
-9.537602
MOAD
ic50=0.29nM
P12497
Protease
CC(C)CN(C[C@@H](O)[C@H](Cc1cccc(F)c1)NC(=O)O[C@H]1[C@H]2CO[C@H]3OC[C@@H]1[C@H]3C2)S(=O)(=O)c1ccc2nc(NC(C)C)oc2c1
674.792
4.1397
152.46
13
47
3
10
0.241296
6oyt
2.824
2,019
NJV
A
1001
ic50
=
20
nM
-7.69897
BindingDB
IC50=20nM
Q99683,Q99683
Mitogen-activated protein kinase kinase kinase 5,Mitogen-activated protein kinase kinase kinase 5
Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
445.502
4.68392
90.52
6
33
1
7
0.465217
6oyt
2.824
2,019
NJV
B
1001
ic50
=
20
nM
-7.69897
BindingDB
IC50=20nM
Q99683,Q99683
Mitogen-activated protein kinase kinase kinase 5,Mitogen-activated protein kinase kinase kinase 5
Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
445.502
4.68392
90.52
6
33
1
7
0.465217
6oyt
2.824
2,019
NJV
C
1001
ic50
=
20
nM
-7.69897
BindingDB
IC50=20nM
Q99683,Q99683
Mitogen-activated protein kinase kinase kinase 5,Mitogen-activated protein kinase kinase kinase 5
Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
445.502
4.68392
90.52
6
33
1
7
0.465217
6oyt
2.824
2,019
NJV
D
1002
ic50
=
20
nM
-7.69897
BindingDB
IC50=20nM
Q99683,Q99683
Mitogen-activated protein kinase kinase kinase 5,Mitogen-activated protein kinase kinase kinase 5
Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
445.502
4.68392
90.52
6
33
1
7
0.465217
6oyw
2.603
2,019
NKJ
A
1001
ic50
=
4
nM
-8.39794
BindingDB
IC50=4.0nM
Q99683
Mitogen-activated protein kinase kinase kinase 5
C[C@H]1CCCOc2ccccc2C(=O)Nc2cccc(n2)-c2nncn21
349.394
3.326
81.93
0
26
1
6
0.673097
6oyw
2.603
2,019
NKJ
B
1001
ic50
=
4
nM
-8.39794
BindingDB
IC50=4.0nM
Q99683
Mitogen-activated protein kinase kinase kinase 5
C[C@H]1CCCOc2ccccc2C(=O)Nc2cccc(n2)-c2nncn21
349.394
3.326
81.93
0
26
1
6
0.673097
6oyw
2.603
2,019
NKJ
C
1001
ic50
=
4
nM
-8.39794
BindingDB
IC50=4.0nM
Q99683
Mitogen-activated protein kinase kinase kinase 5
C[C@H]1CCCOc2ccccc2C(=O)Nc2cccc(n2)-c2nncn21
349.394
3.326
81.93
0
26
1
6
0.673097
6oyw
2.603
2,019
NKJ
D
1001
ic50
=
4
nM
-8.39794
BindingDB
IC50=4.0nM
Q99683
Mitogen-activated protein kinase kinase kinase 5
C[C@H]1CCCOc2ccccc2C(=O)Nc2cccc(n2)-c2nncn21
349.394
3.326
81.93
0
26
1
6
0.673097
6p05
1.54
2,020
YF2
A
203
ic50
=
5.9
nM
-8.229148
MOAD
ic50=5.9nM
O60885
Bromodomain-containing protein 4
CCS(=O)(=O)Nc1cc(-c2cn(C)c3c(=O)[nH]ccc23)cc2c1ccn2C(C)(c1ccccn1)c1ccccn1
552.66
4.8517
114.67
7
40
2
7
0.293841
6p10
2.301
2,019
SKE
B
802
ic50
=
6
uM
-5.221849
MOAD
ic50=6.0uM
Q8I0P1
Drosophila melanogaster Spastin AAA domain
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F
394.363
1.218
145.99
4
27
3
8
0.602789
6p11
2.15
2,019
SKE
B
802
ic50
=
0.9
uM
-6.045757
MOAD
ic50=0.9uM
Q8I0P1
Drosophila melanogaster Spastin AAA domain
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F
394.363
1.218
145.99
4
27
3
8
0.602789
6p12
1.9413185678
2,019
NKY
B
801
ic50
=
0.23
uM
-6.638272
MOAD
ic50=0.23uM
Q8I0P1
Drosophila melanogaster Spastin AAA domain
CNC(=O)c1cccc(Nc2nc(N)n(C(=O)c3c(F)cccc3OC)n2)c1
384.371
1.7997
124.16
5
28
3
8
0.612569
6p13
2.1
2,019
NKY
B
802
ic50
=
0.22
uM
-6.657577
MOAD
ic50=0.22uM
Q8I0P1
Spastin
CNC(=O)c1cccc(Nc2nc(N)n(C(=O)c3c(F)cccc3OC)n2)c1
384.371
1.7997
124.16
5
28
3
8
0.612569
6p14
1.93001125684
2,019
NKY
A
804
ic50
=
0.22
uM
-6.657577
MOAD
ic50=0.22uM
Q8I0P1
Spastin
CNC(=O)c1cccc(Nc2nc(N)n(C(=O)c3c(F)cccc3OC)n2)c1
384.371
1.7997
124.16
5
28
3
8
0.612569
6p1d
2.4
2,019
NQ1
B
1102
ic50
>=
10,000
nM
-5
BindingDB
IC50=>10000nM
P00533
Epidermal growth factor receptor
O=C1c2ccccc2Nc2ccc(F)cc2N1Cc1ccccc1
318.351
4.7297
32.34
2
24
1
2
0.740642
6p1d
2.4
2,019
NQ1
C
1101
ic50
>=
10,000
nM
-5
BindingDB
IC50=>10000nM
P00533
Epidermal growth factor receptor
O=C1c2ccccc2Nc2ccc(F)cc2N1Cc1ccccc1
318.351
4.7297
32.34
2
24
1
2
0.740642
6p1d
2.4
2,019
NQ1
D
1101
ic50
>=
10,000
nM
-5
BindingDB
IC50=>10000nM
P00533
Epidermal growth factor receptor
O=C1c2ccccc2Nc2ccc(F)cc2N1Cc1ccccc1
318.351
4.7297
32.34
2
24
1
2
0.740642
6p1l
2.8
2,019
9LL
A
1103
ic50
=
3
nM
-8.522879
BindingDB
IC50=3.0nM
P00533,P00533
Epidermal growth factor receptor,Epidermal growth factor receptor
O=C(Nc1nccs1)[C@@H](c1cc(F)ccc1O)N1Cc2ccccc2C1=O
383.404
3.3236
82.53
4
27
2
5
0.724063
6p1l
2.8
2,019
9LL
C
1103
ic50
=
3
nM
-8.522879
BindingDB
IC50=3.0nM
P00533
Epidermal growth factor receptor
O=C(Nc1nccs1)[C@@H](c1cc(F)ccc1O)N1Cc2ccccc2C1=O
383.404
3.3236
82.53
4
27
2
5
0.724063
6p1l
2.8
2,019
9LL
D
1103
ic50
=
3
nM
-8.522879
BindingDB
IC50=3.0nM
P00533,P00533
Epidermal growth factor receptor,Epidermal growth factor receptor
O=C(Nc1nccs1)[C@@H](c1cc(F)ccc1O)N1Cc2ccccc2C1=O
383.404
3.3236
82.53
4
27
2
5
0.724063
6p38
2.8
2,020
NQV
A
4000
ic50
=
89
nM
-7.05061
BindingDB
IC50=89nM
P21675
Transcription initiation factor TFIID subunit 1
CC(C)Oc1cc(C(=O)N[C@H]2CC[N@H+](C)CC2)ccc1Nc1ccc2c(n1)N(C1CCCC1)[C@H](C)C(=O)N2C
535.713
3.1332
91.24
7
39
3
6
0.504827
6p39
2.941
2,020
NQY
A
4000
ic50
=
63
nM
-7.200659
BindingDB
IC50=63nM
P21675
Transcription initiation factor TFIID subunit 1
COc1cc(C(=O)N[C@H]2CC[N@H+](C)CC2)ccc1Nc1ccc2c(n1)N1CCCC[C@@H]1C(=O)N2C
479.605
1.576
91.24
5
35
3
6
0.603343
6p3a
2.99
2,020
NQP
A
4000
ic50
=
82
nM
-7.086186
BindingDB
IC50=82nM
P21675,P21675
Transcription initiation factor TFIID subunit 1,Transcription initiation factor TFIID subunit 1
C=CCCN1C(=O)[C@@H](C)N(C2CCOCC2)c2nc(Nc3ccc(C(=O)N[C@H]4CC[N@H+](C)CC4)cc3OC)ccc21
563.723
2.5373
100.47
9
41
3
7
0.403446
6p3a
2.99
2,020
NQP
B
4000
ic50
=
82
nM
-7.086186
BindingDB
IC50=82nM
P21675,P21675
Transcription initiation factor TFIID subunit 1,Transcription initiation factor TFIID subunit 1
C=CCCN1C(=O)[C@@H](C)N(C2CCOCC2)c2nc(Nc3ccc(C(=O)N[C@H]4CC[N@H+](C)CC4)cc3OC)ccc21
563.723
2.5373
100.47
9
41
3
7
0.403446
6p3d
2.11
2,020
0LI
A
1001
ic50
=
14
nM
-7.853872
MOAD
ic50=14.0nM
P15056
Serine/threonine-protein kinase B-raf
Cc1ccc(C(=O)Nc2ccc(C[NH+]3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12
533.578
3.03892
66.97
4
39
2
5
0.396158
6p3p
1.61
2,019
NQJ
A
501
ic50
=
0.145
uM
-6.838632
MOAD
ic50=0.145uM
Q07820
Induced myeloid leukemia cell differentiation protein Mcl-1
COC(=O)[C@@H](Cc1ccccc1)NC(=O)c1cc(C)c(S(=O)(=O)Nc2cc(C(F)(F)F)ccc2Cl)s1
561.003
5.04362
101.57
8
36
2
6
0.375753
6p3t
2.5
2,019
NRS
A
501
ic50
=
0.24
nM
-9.619789
BindingDB
IC50=0.240nM
P9WFK7
N-acetyltransferase Eis
CN(c1ccc2ccccc2c1)S(=O)(=O)c1ccc2[nH]c(=O)c(=O)[nH]c2c1
381.413
2.1947
103.1
3
27
2
4
0.531048
6p4v
1.65
2,020
GC7
A
502
ic50
=
0.14
uM
-6.853872
MOAD
ic50=0.14uM
P49366,P49366
Deoxyhypusine synthase,Deoxyhypusine synthase
[NH3+]CCCCCCCNC([NH3+])[NH3+]
177.316
-2.4642
94.95
8
12
4
1
0.240019
6p4v
1.65
2,020
GC7
B
502
ic50
=
0.14
uM
-6.853872
MOAD
ic50=0.14uM
P49366,P49366
Deoxyhypusine synthase,Deoxyhypusine synthase
[NH3+]CCCCCCCNC([NH3+])[NH3+]
177.316
-2.4642
94.95
8
12
4
1
0.240019
6p5o
1.49
2,019
O2Y
A
703
ic50
=
97
uM
-4.013228
MOAD
ic50=97.0uM
P07379
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
O=C([O-])CSc1cccnc1C(=O)[O-]
211.198
-1.7129
93.15
4
14
0
6
0.550205
6p5v
1.398
2,019
O37
A
1302
ic50
=
0.2
uM
-6.69897
MOAD
ic50=0.2uM
null
null
CCN1C(=O)[C@@H](NC(=O)c2cccc(C)c2)[C@@H](c2ccc(F)cc2)c2c(C)nn([C@@H]3CC=CCC3)c21
486.591
5.21724
67.23
5
36
1
4
0.503216
6p5w
1.69
2,019
O0A
A
1301
ic50
=
5.1
uM
-5.29243
MOAD
ic50=5.1uM
null
null
Cc1ccc([C@H]2c3c(C)nn(-c4ccccc4)c3NC(=O)[C@H]2NC(=O)c2cccc(C)c2)cc1
450.542
4.68016
76.02
4
34
2
4
0.474033
6p6g
1.59
2,020
LUP
A
510
ki
=
6
nM
-8.221849
MOAD
Ki=6.0nM
Q9H7B4
Histone-lysine N-methyltransferase SMYD3
O=C(NC1CCN(S(=O)(=O)C[C@H]2CC[C@H]([NH2+]CCCC(F)(F)F)CC2)CC1)c1cc(C2CC2)on1
521.626
2.5407
109.12
10
35
2
5
0.460221
6p6k
1.55
2,020
L0J
A
508
ic50
=
1,421
nM
-5.847406
BindingDB
IC50=1421nM
Q9H7B4
Histone-lysine N-methyltransferase SMYD3
[NH3+]CCS(=O)(=O)N1CCC(NC(=O)c2cc(C3CC3)on2)CC1
343.429
-0.6821
120.15
6
23
2
5
0.708765
6p7z
1.19
2,020
O41
A
507
ic50
=
5,010
nM
-5.300162
BindingDB
IC50=5010nM
Q9H7B4
Histone-lysine N-methyltransferase SMYD3
CS(=O)(=O)N1CCC(NC(=O)c2cc(C3CC3)on2)CC1
313.379
0.7058
92.51
4
21
1
5
0.883314
6p83
1.7
2,019
O3Y
A
403
kd
=
0.08
uM
-7.09691
MOAD
Kd=0.08uM
P21645,P21645,P21645
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase,UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase,UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase
CC1(C)CC(=O)c2c(nc3nn(-c4ccccc4)c(O)c3c2-c2ccccc2Cl)C1
417.896
5.6016
68.01
2
30
1
5
0.460478
6p83
1.7
2,019
O3Y
B
501
kd
=
0.08
uM
-7.09691
MOAD
Kd=0.08uM
P21645,P21645,P21645
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase,UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase,UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase
CC1(C)CC(=O)c2c(nc3nn(-c4ccccc4)c(O)c3c2-c2ccccc2Cl)C1
417.896
5.6016
68.01
2
30
1
5
0.460478
6p83
1.7
2,019
O3Y
C
501
kd
=
0.08
uM
-7.09691
MOAD
Kd=0.08uM
P21645,P21645,P21645
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase,UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase,UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase
CC1(C)CC(=O)c2c(nc3nn(-c4ccccc4)c(O)c3c2-c2ccccc2Cl)C1
417.896
5.6016
68.01
2
30
1
5
0.460478
6p9a
1.66
2,020
017
A
101
ki
=
4
nM
-8.39794
MOAD
Ki=4.0nM
P03367,P03367
HIV-1 Protease,HIV-1 Protease
CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CO[C@H]2OCC[C@H]21)S(=O)(=O)c1ccc(N)cc1
547.674
2.3753
140.42
11
38
3
8
0.364423
6p9b
1.75
2,020
478
A
101
ki
=
3.6
nM
-8.443697
MOAD
Ki=3.6nM
P03367,P03367
HIV-1 protease,HIV-1 protease
CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)c1ccc(N)cc1
505.637
2.4028
131.19
11
35
3
7
0.39974
6p9e
2.0
2,019
O6D
A
4000
kd
=
67.6
nM
-7.170053
MOAD
Kd=67.6nM
Q9NZH8
Interleukin-36 gamma
COC(c1ccccc1)(c1ccccc1)[C@H](Oc1nc(C)cc(-c2ccc(C)c(N)c2)n1)C(=O)[O-]
468.533
3.43014
110.39
8
35
1
7
0.394532
6p9g
2.1
2,019
O4Y
A
302
kd
=
60,000
nM
-4.221849
BindingDB
Kd=60000nM
P45974
Ubiquitin carboxyl-terminal hydrolase 5
C[C@H](C(=O)[O-])n1cnc2ccccc2c1=O
217.204
-0.2926
75.02
2
16
0
5
0.692162
6p9p
2.0
2,020
O5J
A
406
kd
=
0.1
uM
-7
MOAD
Kd=0.1uM
P0A722
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
COc1ccc(C(=O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)cc1
400.434
3.3735
75.71
6
30
1
4
0.508487
6p9q
1.7
2,020
O5P
A
307
kd
=
110
uM
-3.958607
MOAD
Kd=110.0uM
P0A722
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Cc1ccnc(-c2cc(C(=O)N3CCOC[C@H]3Cc3ccccc3)n[nH]2)c1
362.433
2.86382
71.11
4
27
1
4
0.774678
6p9r
1.75
2,020
O5M
A
307
ic50
=
3
uM
-5.522879
MOAD
ic50=3.0uM
P0A722
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Cc1ccnc(-c2cc(C(=O)N3CCOC[C@H]3Cc3ccccc3F)[nH]n2)c1
380.423
3.00292
71.11
4
28
1
4
0.755365
6p9s
1.7
2,020
O5G
A
307
ic50
=
11
uM
-4.958607
MOAD
ic50=11.0uM
P0A722
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
COc1ccccc1C[C@@H]1COCCN1C(=O)c1cc(-c2cc(C)ccn2)n[nH]1
392.459
2.87242
80.34
5
29
1
5
0.722194
6p9t
1.75
2,020
O5D
A
307
ic50
=
0.6
uM
-6.221849
MOAD
ic50=0.6uM
P0A722
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
COc1cccc(Cl)c1C[C@@H]1COCCN1C(=O)c1cc(-c2cc(C)c(N)cn2)n[nH]1
441.919
3.10802
106.36
5
31
2
6
0.629677
6p9z
1.86
2,019
MTX
X
201
ki
=
0.71
nM
-9.148742
MOAD
Ki=0.71nM
P0A017
Dihydrofolate reductase
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])cc1
452.431
-2.401
216.2
9
33
3
12
0.30942
6paf
1.241
2,020
O6A
A
509
ic50
=
63
nM
-7.200659
BindingDB
EC50=204nM,IC50=63nM
Q9H7B4
Histone-lysine N-methyltransferase SMYD3
[NH3+]Cc1ccc(S(=O)(=O)N2CCC(NC(=O)c3cc(C4CC4)on3)CC2)cc1
405.5
0.877
120.15
6
28
2
5
0.739035
6pay
2.199
2,019
ICT
A
501
kd
=
0.51
mM
-3.29243
MOAD
Kd=0.51mM
O75874,O75874
Isocitrate dehydrogenase [NADP] cytoplasmic,Isocitrate dehydrogenase [NADP] cytoplasmic
O=C([O-])C[C@H](C(=O)[O-])[C@@H](O)C(=O)[O-]
189.099
-5.3967
140.62
5
13
1
7
0.45446
6pay
2.199
2,019
ICT
B
501
kd
=
0.51
mM
-3.29243
MOAD
Kd=0.51mM
O75874,O75874
Isocitrate dehydrogenase [NADP] cytoplasmic,Isocitrate dehydrogenase [NADP] cytoplasmic
O=C([O-])C[C@H](C(=O)[O-])[C@@H](O)C(=O)[O-]
189.099
-5.3967
140.62
5
13
1
7
0.45446
6pay
2.199
2,019
ICT
C
501
kd
=
0.51
mM
-3.29243
MOAD
Kd=0.51mM
O75874,O75874
Isocitrate dehydrogenase [NADP] cytoplasmic,Isocitrate dehydrogenase [NADP] cytoplasmic
O=C([O-])C[C@H](C(=O)[O-])[C@@H](O)C(=O)[O-]
189.099
-5.3967
140.62
5
13
1
7
0.45446
6pay
2.199
2,019
ICT
D
501
kd
=
0.51
mM
-3.29243
MOAD
Kd=0.51mM
O75874,O75874
Isocitrate dehydrogenase [NADP] cytoplasmic,Isocitrate dehydrogenase [NADP] cytoplasmic
O=C([O-])C[C@H](C(=O)[O-])[C@@H](O)C(=O)[O-]
189.099
-5.3967
140.62
5
13
1
7
0.45446
6pbi
1.9
2,020
O6Y
A
201
kd
=
365
uM
-3.437707
MOAD
Kd=365.0uM
P0AEG4,P0AEG4
Thiol:disulfide interchange protein DsbA,Thiol:disulfide interchange protein DsbA
Cc1cc(Oc2ccc(CC(=O)N3CCOCC3)cc2)ccc1C#N
336.391
3.0603
62.56
4
25
0
4
0.860726
6pbo
1.649
2,019
O71
X
201
ki
=
2
nM
-8.69897
MOAD
Ki=2.0nM
P0A017
Dihydrofolate reductase
CCc1nc(N)nc(N)c1C#C[C@@H](C)c1cc2c(c(-c3ccc(CC(=O)[O-])cc3)c1)OCO2
443.483
2.0467
136.41
5
33
2
8
0.571871
6pc9
2.3
2,020
O7P
A
201
kd
=
480
uM
-3.318759
MOAD
Kd=480.0uM
P0AEG4,P0AEG4
Thiol:disulfide interchange protein DsbA,Thiol:disulfide interchange protein DsbA
Cc1cc(Oc2ccc(CC(=O)N3CCN(C)C(=O)C3)cc2)ccc1C#N
363.417
2.5021
73.64
4
27
0
4
0.836545
6pd7
1.92
2,020
OAJ
A
201
kd
=
290
uM
-3.537602
MOAD
Kd=290.0uM
P0AEG4,P0AEG4
Thiol:disulfide interchange protein DsbA,Thiol:disulfide interchange protein DsbA
Cc1cc(Oc2ccc(CC(=O)N3CCOC[C@@H]3C(=O)[O-])cc2)ccc1C#N
379.392
1.1788
102.69
5
28
0
6
0.77287
6pdh
1.96
2,020
OAV
A
201
kd
=
62
uM
-4.207608
MOAD
Kd=62.0uM
P0AEG4,P0AEG4
Thiol:disulfide interchange protein DsbA,Thiol:disulfide interchange protein DsbA
CCN(CCn1cccn1)C(=O)Cc1ccc(Oc2ccc(C#N)c(C)c2)cc1
388.471
3.9467
71.15
8
29
0
5
0.585821
6pdj
1.81
2,019
ODJ
A
601
ic50
=
42
nM
-7.376751
BindingDB
IC50=42nM
P06239
Tyrosine-protein kinase Lck
COc1ccc2c(C(=O)Nc3ccc(NC(=O)c4nn(C)c5ccccc45)cc3C)cnn2c1
454.49
4.04262
102.55
5
34
2
7
0.417252
6peb
2.46
2,019
OE4
A
601
ic50
=
2.7
nM
-8.568636
MOAD
ic50=2.7nM
P43490,P43490
Nicotinamide phosphoribosyltransferase,Nicotinamide phosphoribosyltransferase
O=C(Nc1ccc(CN2C(=O)c3ccccc3C2=O)cc1)N1CC(c2cccnc2)C1
412.449
3.5091
82.61
4
31
1
4
0.665084
6peb
2.46
2,019
OE4
B
601
ic50
=
2.7
nM
-8.568636
MOAD
ic50=2.7nM
P43490,P43490
Nicotinamide phosphoribosyltransferase,Nicotinamide phosphoribosyltransferase
O=C(Nc1ccc(CN2C(=O)c3ccccc3C2=O)cc1)N1CC(c2cccnc2)C1
412.449
3.5091
82.61
4
31
1
4
0.665084
6peb
2.46
2,019
OE4
C
601
ic50
=
2.7
nM
-8.568636
MOAD
ic50=2.7nM
P43490,P43490
Nicotinamide phosphoribosyltransferase,Nicotinamide phosphoribosyltransferase
O=C(Nc1ccc(CN2C(=O)c3ccccc3C2=O)cc1)N1CC(c2cccnc2)C1
412.449
3.5091
82.61
4
31
1
4
0.665084
6pet
2.203
2,019
ODY
A
601
ic50
=
0.05
nM
-10.30103
BindingDB
IC50=0.050000nM
P03372
Estrogen receptor
CC1=C(c2cccc(O)c2)[C@H](c2ccc(OCC[N@H+]3C[C@@H](CF)C3)cc2)Oc2c(O)cccc21
462.541
4.0252
63.36
7
34
3
4
0.496339
6pet
2.203
2,019
ODY
B
601
ic50
=
0.05
nM
-10.30103
BindingDB
IC50=0.050000nM
P03372
Estrogen receptor
CC1=C(c2cccc(O)c2)[C@H](c2ccc(OCC[N@H+]3C[C@@H](CF)C3)cc2)Oc2c(O)cccc21
462.541
4.0252
63.36
7
34
3
4
0.496339
6pf1
2.32
2,019
OJ7
A
1702
ic50
=
39
uM
-4.408935
MOAD
ic50=39.0uM
Q09472
Histone acetyltransferase p300
Cc1[nH]c2ccccc2c1-c1ncc(C(F)(F)F)cc1Cl
310.706
5.21052
28.68
1
21
1
1
0.656366
6pf1
2.32
2,019
OJ7
B
1702
ic50
=
39
uM
-4.408935
MOAD
ic50=39.0uM
Q09472
Histone acetyltransferase p300
Cc1[nH]c2ccccc2c1-c1ncc(C(F)(F)F)cc1Cl
310.706
5.21052
28.68
1
21
1
1
0.656366
6pfj
2.08
2,019
C2E
T
202
kd
=
0.39
uM
-6.408935
MOAD
Kd=0.39uM
A0A3N1Q704,F2RFR7
RNA polymerase sigma factor,AmfC protein
Nc1nc2c(ncn2[C@@H]2O[C@@H]3CO[P@](=O)([O-])O[C@H]4[C@@H](O)[C@H](n5cnc6c(=O)[nH]c(N)nc65)O[C@@H]4CO[P@](=O)([O-])O[C@H]3[C@H]2O)c(=O)[nH]1
688.4
-4.3122
355.28
2
46
6
22
0.10841
6pfj
2.08
2,019
C2E
T
201
kd
=
0.39
uM
-6.408935
MOAD
Kd=0.39uM
A0A3N1Q704,F2RFR7
RNA polymerase sigma factor,AmfC protein
Nc1nc2c(ncn2[C@@H]2O[C@@H]3CO[P@](=O)([O-])O[C@H]4[C@@H](O)[C@H](n5cnc6c(=O)[nH]c(N)nc65)O[C@@H]4CO[P@](=O)([O-])O[C@H]3[C@H]2O)c(=O)[nH]1
688.4
-4.3122
355.28
2
46
6
22
0.10841
6pfm
2.84
2,019
OGJ
A
601
ic50
=
0.03
nM
-10.522879
BindingDB
IC50=0.030000nM
P03372
Estrogen receptor
CC1=C(c2cccc(O)c2)[C@H](c2ccc(OCC[N@H+]3C[C@@H](CF)C3)cc2)Oc2ccc(O)cc21
462.541
4.0252
63.36
7
34
3
4
0.496339
6pfm
2.84
2,019
OGJ
D
601
ic50
=
0.03
nM
-10.522879
BindingDB
IC50=0.030000nM
P03372
Estrogen receptor
CC1=C(c2cccc(O)c2)[C@H](c2ccc(OCC[N@H+]3C[C@@H](CF)C3)cc2)Oc2ccc(O)cc21
462.541
4.0252
63.36
7
34
3
4
0.496339
6pg1
2.01
2,020
O7P
A
201
kd
=
480,000
nM
-3.318759
BindingDB
Kd=480000nM
P0AEG4,P0AEG4
Thiol:disulfide interchange protein DsbA,Thiol:disulfide interchange protein DsbA
Cc1cc(Oc2ccc(CC(=O)N3CCN(C)C(=O)C3)cc2)ccc1C#N
363.417
2.5021
73.64
4
27
0
4
0.836545
6pg2
1.91
2,020
O6Y
A
201
kd
=
365,000
nM
-3.437707
BindingDB
Kd=365000nM
P0AEG4,P0AEG4
Thiol:disulfide interchange protein DsbA,Thiol:disulfide interchange protein DsbA
Cc1cc(Oc2ccc(CC(=O)N3CCOCC3)cc2)ccc1C#N
336.391
3.0603
62.56
4
25
0
4
0.860726
6pg3
2.04
2,019
OHJ
A
401
kd
=
480
uM
-3.318759
MOAD
Kd=480.0uM
P61964
WD repeat-containing protein 5
CCCCc1nc(CO)c[nH]1
154.213
1.2446
48.91
4
11
2
2
0.6852
6pg3
2.04
2,019
OHJ
B
401
kd
=
480
uM
-3.318759
MOAD
Kd=480.0uM
P61964
WD repeat-containing protein 5
CCCCc1nc(CO)c[nH]1
154.213
1.2446
48.91
4
11
2
2
0.6852
6pg4
1.6
2,019
OHG
A
401
kd
=
260
uM
-3.585027
MOAD
Kd=260.0uM
P61964
WD repeat-containing protein 5
Cc1nc(CO)c[nH]1
112.132
0.21042
48.91
1
8
2
2
0.54525
6pg5
1.99
2,019
OHV
A
401
kd
=
11
uM
-4.958607
MOAD
Kd=11.0uM
P61964
WD repeat-containing protein 5
O=C(NCCCCc1ncc(CO)[nH]1)OCc1ccccc1
303.362
2.1511
87.24
8
22
3
4
0.6521
6pg6
1.68
2,019
OH7
A
402
kd
=
200
uM
-3.69897
MOAD
Kd=200.0uM
P61964
WD repeat-containing protein 5
CC(=O)NCCCCc1nc(CO)c[nH]1
211.265
0.3608
78.01
6
15
3
3
0.594445
6pg6
1.68
2,019
OH7
B
402
kd
=
200
uM
-3.69897
MOAD
Kd=200.0uM
P61964
WD repeat-containing protein 5
CC(=O)NCCCCc1nc(CO)c[nH]1
211.265
0.3608
78.01
6
15
3
3
0.594445
6pg7
2.45
2,019
OH4
A
401
kd
=
22
uM
-4.657577
MOAD
Kd=22.0uM
P61964
WD repeat-containing protein 5
CO[C@@H](CCc1nc(CO)c[nH]1)c1ccccc1
246.31
2.2223
58.14
6
18
2
3
0.821324
6pg8
1.67
2,019
OGY
A
401
kd
=
140
uM
-3.853872
MOAD
Kd=140.0uM
P61964,P61964
WD repeat-containing protein 5,WD repeat-containing protein 5
OCc1c[nH]c(CCCc2ccccc2)n1
216.284
2.0773
48.91
5
16
2
2
0.803517
6pg8
1.67
2,019
OGY
B
401
kd
=
140
uM
-3.853872
MOAD
Kd=140.0uM
P61964
WD repeat-containing protein 5
OCc1c[nH]c(CCCc2ccccc2)n1
216.284
2.0773
48.91
5
16
2
2
0.803517