PDBID
stringlengths
4
4
Resolution
stringlengths
1
13
Year
int64
1.98k
2.02k
Ligand Name
stringlengths
1
7
Ligand Chain
stringclasses
53 values
Ligand Residue Number
stringlengths
1
9
Binding Affinity Measurement
stringclasses
4 values
Binding Affinity Sign
stringclasses
6 values
Binding Affinity Value
float64
0
500M
Binding Affinity Unit
stringclasses
6 values
Log Binding Affinity
float64
-14
2.97
Binding Affinity Source
stringclasses
3 values
Binding Affinity Annotation
stringlengths
6
72
Protein UniProtID
stringlengths
6
55
Protein UniProtName
stringlengths
2
575
Ligand SMILES
stringlengths
4
352
Ligand MW
float64
44
1.82k
Ligand LogP
float64
-23.01
13.7
Ligand TPSA
float64
0
786
Ligand NumRotBond
int64
0
59
Ligand NumHeavyAtoms
int64
3
120
Ligand NumHDon
int64
0
30
Ligand NumHAcc
int64
0
56
Ligand QED
float64
0.01
0.95
6pn1
2.196
2,020
OSG
A
803
ki
=
0.072
uM
-7.142668
MOAD
Ki=0.072uM
P29476,P29476
Nitric oxide synthase, brain,Nitric oxide synthase, brain
CCCOc1ccc(-c2ccc3c(C)cc(N)nc3c2)cc1C[NH3+]
322.432
3.32312
75.78
5
24
2
3
0.756322
6pn1
2.196
2,020
OSG
B
803
ki
=
0.072
uM
-7.142668
MOAD
Ki=0.072uM
P29476,P29476
Nitric oxide synthase, brain,Nitric oxide synthase, brain
CCCOc1ccc(-c2ccc3c(C)cc(N)nc3c2)cc1C[NH3+]
322.432
3.32312
75.78
5
24
2
3
0.756322
6pn2
1.877
2,020
OSD
A
803
ki
=
0.071
uM
-7.148742
MOAD
Ki=0.071uM
P29476,P29476
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OC(C)C)c(C[NH3+])c3)ccc12
322.432
3.32152
75.78
4
24
2
3
0.773406
6pn2
1.877
2,020
OSD
B
803
ki
=
0.071
uM
-7.148742
MOAD
Ki=0.071uM
P29476,P29476
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OC(C)C)c(C[NH3+])c3)ccc12
322.432
3.32152
75.78
4
24
2
3
0.773406
6pn3
1.8
2,020
OUP
A
803
ki
=
0.049
uM
-7.309804
MOAD
Ki=0.049uM
P29476,P29476
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCC4CCC4)c(C[NH3+])c3)ccc12
348.47
3.71322
75.78
5
26
2
3
0.737778
6pn3
1.8
2,020
OUP
B
803
ki
=
0.049
uM
-7.309804
MOAD
Ki=0.049uM
P29476,P29476
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCC4CCC4)c(C[NH3+])c3)ccc12
348.47
3.71322
75.78
5
26
2
3
0.737778
6pn4
1.898
2,020
OU1
A
803
ki
=
0.039
uM
-7.408935
MOAD
Ki=0.039uM
P29476,P29476
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCC4CC4)c(C[NH3+])c3)ccc12
334.443
3.32312
75.78
5
25
2
3
0.751309
6pn4
1.898
2,020
OU1
B
803
ki
=
0.039
uM
-7.408935
MOAD
Ki=0.039uM
P29476,P29476
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCC4CC4)c(C[NH3+])c3)ccc12
334.443
3.32312
75.78
5
25
2
3
0.751309
6pn5
1.699
2,020
OS7
A
803
ki
=
0.052
uM
-7.283997
MOAD
Ki=0.052uM
P29476,P29476
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4ccccn4)c(C[NH3+])c3)ccc12
371.464
3.50832
88.67
5
28
2
4
0.56179
6pn5
1.699
2,020
OS7
B
803
ki
=
0.052
uM
-7.283997
MOAD
Ki=0.052uM
P29476,P29476
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4ccccn4)c(C[NH3+])c3)ccc12
371.464
3.50832
88.67
5
28
2
4
0.56179
6pn6
1.843
2,020
OUS
A
803
ki
=
0.044
uM
-7.356547
MOAD
Ki=0.044uM
P29476,P29476
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4cccnc4)c(C[NH3+])c3)ccc12
371.464
3.50832
88.67
5
28
2
4
0.56179
6pn6
1.843
2,020
OUS
B
803
ki
=
0.044
uM
-7.356547
MOAD
Ki=0.044uM
P29476,P29476
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4cccnc4)c(C[NH3+])c3)ccc12
371.464
3.50832
88.67
5
28
2
4
0.56179
6pn7
1.878
2,020
OUJ
A
803
ki
=
0.043
uM
-7.366532
MOAD
Ki=0.043uM
P29476,P29476
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4cscn4)c(C[NH3+])c3)ccc12
377.493
3.56982
88.67
5
27
2
5
0.556377
6pn7
1.878
2,020
OUJ
B
803
ki
=
0.043
uM
-7.366532
MOAD
Ki=0.043uM
P29476,P29476
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4cscn4)c(C[NH3+])c3)ccc12
377.493
3.56982
88.67
5
27
2
5
0.556377
6pn8
1.838
2,020
OU4
A
803
ki
=
0.043
uM
-7.366532
MOAD
Ki=0.043uM
P29476,P29476
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4cocn4)c(C[NH3+])c3)ccc12
361.425
3.10132
101.81
5
27
2
5
0.568581
6pn8
1.838
2,020
OU4
B
803
ki
=
0.043
uM
-7.366532
MOAD
Ki=0.043uM
P29476,P29476
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4cocn4)c(C[NH3+])c3)ccc12
361.425
3.10132
101.81
5
27
2
5
0.568581
6pn9
1.84
2,020
OU7
A
803
ki
=
0.053
uM
-7.275724
MOAD
Ki=0.053uM
P29476,P29476
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4cncs4)c(C[NH3+])c3)ccc12
377.493
3.56982
88.67
5
27
2
5
0.556377
6pn9
1.84
2,020
OU7
B
803
ki
=
0.053
uM
-7.275724
MOAD
Ki=0.053uM
P29476,P29476
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4cncs4)c(C[NH3+])c3)ccc12
377.493
3.56982
88.67
5
27
2
5
0.556377
6pna
1.95
2,020
M16
A
803
ki
=
0.122
uM
-6.91364
MOAD
Ki=0.122uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(CC[NH3+])cc3)ccc12
278.379
2.57682
66.55
3
21
2
2
0.772972
6pna
1.95
2,020
M16
B
803
ki
=
0.122
uM
-6.91364
MOAD
Ki=0.122uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(CC[NH3+])cc3)ccc12
278.379
2.57682
66.55
3
21
2
2
0.772972
6pnb
2.05
2,020
OSY
A
803
ki
=
0.088
uM
-7.055517
MOAD
Ki=0.088uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(C[NH3+])cc3)ccc12
264.352
2.53432
66.55
2
20
2
2
0.746606
6pnb
2.05
2,020
OSY
B
803
ki
=
0.088
uM
-7.055517
MOAD
Ki=0.088uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(C[NH3+])cc3)ccc12
264.352
2.53432
66.55
2
20
2
2
0.746606
6pnc
2.15
2,020
OUG
A
803
ki
=
0.06
uM
-7.221849
MOAD
Ki=0.06uM
P29475
Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3cccc(C[NH3+])c3)ccc12
264.352
2.53432
66.55
2
20
2
2
0.746606
6pnc
2.15
2,020
OUG
B
803
ki
=
0.06
uM
-7.221849
MOAD
Ki=0.06uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3cccc(C[NH3+])c3)ccc12
264.352
2.53432
66.55
2
20
2
2
0.746606
6pnf
2.1
2,020
OSJ
A
803
ki
=
0.111
uM
-6.954677
MOAD
Ki=0.111uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
CCOc1ccc(-c2ccc3c(C)cc(N)nc3c2)cc1C[NH3+]
308.405
2.93302
75.78
4
23
2
3
0.777796
6pnf
2.1
2,020
OSJ
B
803
ki
=
0.111
uM
-6.954677
MOAD
Ki=0.111uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
CCOc1ccc(-c2ccc3c(C)cc(N)nc3c2)cc1C[NH3+]
308.405
2.93302
75.78
4
23
2
3
0.777796
6png
1.775
2,020
OSG
A
803
ki
=
0.058
uM
-7.236572
MOAD
Ki=0.058uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
CCCOc1ccc(-c2ccc3c(C)cc(N)nc3c2)cc1C[NH3+]
322.432
3.32312
75.78
5
24
2
3
0.756322
6png
1.775
2,020
OSG
A
802
ki
=
0.058
uM
-7.236572
MOAD
Ki=0.058uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
CCCOc1ccc(-c2ccc3c(C)cc(N)nc3c2)cc1C[NH3+]
322.432
3.32312
75.78
5
24
2
3
0.756322
6png
1.775
2,020
OSG
B
801
ki
=
0.058
uM
-7.236572
MOAD
Ki=0.058uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
CCCOc1ccc(-c2ccc3c(C)cc(N)nc3c2)cc1C[NH3+]
322.432
3.32312
75.78
5
24
2
3
0.756322
6png
1.775
2,020
OSG
B
804
ki
=
0.058
uM
-7.236572
MOAD
Ki=0.058uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
CCCOc1ccc(-c2ccc3c(C)cc(N)nc3c2)cc1C[NH3+]
322.432
3.32312
75.78
5
24
2
3
0.756322
6pnh
1.85
2,020
OSD
A
803
ki
=
0.066
uM
-7.180456
MOAD
Ki=0.066uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OC(C)C)c(C[NH3+])c3)ccc12
322.432
3.32152
75.78
4
24
2
3
0.773406
6pnh
1.85
2,020
OSD
A
802
ki
=
0.066
uM
-7.180456
MOAD
Ki=0.066uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OC(C)C)c(C[NH3+])c3)ccc12
322.432
3.32152
75.78
4
24
2
3
0.773406
6pnh
1.85
2,020
OSD
B
801
ki
=
0.066
uM
-7.180456
MOAD
Ki=0.066uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OC(C)C)c(C[NH3+])c3)ccc12
322.432
3.32152
75.78
4
24
2
3
0.773406
6pnh
1.85
2,020
OSD
B
804
ki
=
0.066
uM
-7.180456
MOAD
Ki=0.066uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OC(C)C)c(C[NH3+])c3)ccc12
322.432
3.32152
75.78
4
24
2
3
0.773406
6po5
1.82
2,020
OUP
A
803
ki
=
0.096
uM
-7.017729
MOAD
Ki=0.096uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCC4CCC4)c(C[NH3+])c3)ccc12
348.47
3.71322
75.78
5
26
2
3
0.737778
6po5
1.82
2,020
OUP
B
804
ki
=
0.096
uM
-7.017729
MOAD
Ki=0.096uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCC4CCC4)c(C[NH3+])c3)ccc12
348.47
3.71322
75.78
5
26
2
3
0.737778
6po7
1.95
2,020
OU1
A
803
ki
=
0.046
uM
-7.337242
MOAD
Ki=0.046uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCC4CC4)c(C[NH3+])c3)ccc12
334.443
3.32312
75.78
5
25
2
3
0.751309
6po7
1.95
2,020
OU1
B
803
ki
=
0.046
uM
-7.337242
MOAD
Ki=0.046uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCC4CC4)c(C[NH3+])c3)ccc12
334.443
3.32312
75.78
5
25
2
3
0.751309
6po8
1.898
2,020
OUM
A
803
ki
=
0
null
null
MOAD
Ki=1.14e-07nan
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4ccc(C#N)cc4)c(C[NH3+])c3)ccc12
395.486
3.985
99.57
5
30
2
4
0.533624
6po8
1.898
2,020
OUM
B
804
ki
=
0
null
null
MOAD
Ki=1.14e-07nan
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4ccc(C#N)cc4)c(C[NH3+])c3)ccc12
395.486
3.985
99.57
5
30
2
4
0.533624
6po9
1.808
2,020
OS7
A
803
ki
=
0.076
uM
-7.119186
MOAD
Ki=0.076uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4ccccn4)c(C[NH3+])c3)ccc12
371.464
3.50832
88.67
5
28
2
4
0.56179
6po9
1.808
2,020
OS7
B
804
ki
=
0.076
uM
-7.119186
MOAD
Ki=0.076uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4ccccn4)c(C[NH3+])c3)ccc12
371.464
3.50832
88.67
5
28
2
4
0.56179
6poa
1.809
2,020
OUS
A
804
ki
=
0.045
uM
-7.346787
MOAD
Ki=0.045uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4cccnc4)c(C[NH3+])c3)ccc12
371.464
3.50832
88.67
5
28
2
4
0.56179
6poa
1.809
2,020
OUS
A
803
ki
=
0.045
uM
-7.346787
MOAD
Ki=0.045uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4cccnc4)c(C[NH3+])c3)ccc12
371.464
3.50832
88.67
5
28
2
4
0.56179
6poa
1.809
2,020
OUS
B
804
ki
=
0.045
uM
-7.346787
MOAD
Ki=0.045uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4cccnc4)c(C[NH3+])c3)ccc12
371.464
3.50832
88.67
5
28
2
4
0.56179
6pob
1.95
2,020
OUJ
A
803
ki
=
0.031
uM
-7.508638
MOAD
Ki=0.031uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4cscn4)c(C[NH3+])c3)ccc12
377.493
3.56982
88.67
5
27
2
5
0.556377
6pob
1.95
2,020
OUJ
B
804
ki
=
0.031
uM
-7.508638
MOAD
Ki=0.031uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4cscn4)c(C[NH3+])c3)ccc12
377.493
3.56982
88.67
5
27
2
5
0.556377
6poc
1.998
2,020
OU4
A
803
ki
=
0.063
uM
-7.200659
MOAD
Ki=0.063uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4cocn4)c(C[NH3+])c3)ccc12
361.425
3.10132
101.81
5
27
2
5
0.568581
6poc
1.998
2,020
OU4
A
802
ki
=
0.063
uM
-7.200659
MOAD
Ki=0.063uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4cocn4)c(C[NH3+])c3)ccc12
361.425
3.10132
101.81
5
27
2
5
0.568581
6poc
1.998
2,020
OU4
B
803
ki
=
0.063
uM
-7.200659
MOAD
Ki=0.063uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4cocn4)c(C[NH3+])c3)ccc12
361.425
3.10132
101.81
5
27
2
5
0.568581
6poc
1.998
2,020
OU4
B
804
ki
=
0.063
uM
-7.200659
MOAD
Ki=0.063uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4cocn4)c(C[NH3+])c3)ccc12
361.425
3.10132
101.81
5
27
2
5
0.568581
6poh
1.67
2,019
OVG
A
201
kd
=
1,970
uM
-2.705534
MOAD
Kd=1970.0uM
P0AEG4,P0AEG4
Thiol:disulfide interchange protein DsbA,Thiol:disulfide interchange protein DsbA
CCCCOc1ccc2c(CC(=O)[O-])coc2c1
247.27
1.9041
62.5
6
18
0
4
0.731307
6poi
1.77
2,019
OVS
A
201
kd
=
326
uM
-3.486782
MOAD
Kd=326.0uM
P0AEG4,P0AEG4
Thiol:disulfide interchange protein DsbA,Thiol:disulfide interchange protein DsbA
O=C([O-])Cc1coc2cc(Oc3ccccc3)ccc12
267.26
2.5175
62.5
4
20
0
4
0.728289
6poq
1.8
2,019
OVJ
A
201
kd
=
2,700
uM
-2.568636
MOAD
Kd=2700.0uM
P0AEG4,P0AEG4
Thiol:disulfide interchange protein DsbA,Thiol:disulfide interchange protein DsbA
COc1ccc(Nc2ccc3c(CC(=O)[O-])coc3c2)cc1
296.302
2.4774
74.53
5
22
1
5
0.782581
6pot
2.3
2,020
OU7
A
803
ki
=
0.046
uM
-7.337242
MOAD
Ki=0.046uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4cncs4)c(C[NH3+])c3)ccc12
377.493
3.56982
88.67
5
27
2
5
0.556377
6pot
2.3
2,020
OU7
B
804
ki
=
0.046
uM
-7.337242
MOAD
Ki=0.046uM
P29475,P29475
Nitric oxide synthase, brain,Nitric oxide synthase, brain
Cc1cc(N)nc2cc(-c3ccc(OCc4cncs4)c(C[NH3+])c3)ccc12
377.493
3.56982
88.67
5
27
2
5
0.556377
6pou
2.194
2,020
M16
A
502
ki
=
23.3
uM
-4.632644
MOAD
Ki=23.3uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(CC[NH3+])cc3)ccc12
278.379
2.57682
66.55
3
21
2
2
0.772972
6pou
2.194
2,020
M16
A
503
ki
=
23.3
uM
-4.632644
MOAD
Ki=23.3uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(CC[NH3+])cc3)ccc12
278.379
2.57682
66.55
3
21
2
2
0.772972
6pou
2.194
2,020
M16
B
502
ki
=
23.3
uM
-4.632644
MOAD
Ki=23.3uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(CC[NH3+])cc3)ccc12
278.379
2.57682
66.55
3
21
2
2
0.772972
6pou
2.194
2,020
M16
B
503
ki
=
23.3
uM
-4.632644
MOAD
Ki=23.3uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(CC[NH3+])cc3)ccc12
278.379
2.57682
66.55
3
21
2
2
0.772972
6pou
2.194
2,020
M16
C
502
ki
=
23.3
uM
-4.632644
MOAD
Ki=23.3uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(CC[NH3+])cc3)ccc12
278.379
2.57682
66.55
3
21
2
2
0.772972
6pou
2.194
2,020
M16
C
503
ki
=
23.3
uM
-4.632644
MOAD
Ki=23.3uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(CC[NH3+])cc3)ccc12
278.379
2.57682
66.55
3
21
2
2
0.772972
6pou
2.194
2,020
M16
D
502
ki
=
23.3
uM
-4.632644
MOAD
Ki=23.3uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(CC[NH3+])cc3)ccc12
278.379
2.57682
66.55
3
21
2
2
0.772972
6pou
2.194
2,020
M16
D
503
ki
=
23.3
uM
-4.632644
MOAD
Ki=23.3uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(CC[NH3+])cc3)ccc12
278.379
2.57682
66.55
3
21
2
2
0.772972
6pou
2.194
2,020
M16
E
502
ki
=
23.3
uM
-4.632644
MOAD
Ki=23.3uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(CC[NH3+])cc3)ccc12
278.379
2.57682
66.55
3
21
2
2
0.772972
6pou
2.194
2,020
M16
F
804
ki
=
23.3
uM
-4.632644
MOAD
Ki=23.3uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(CC[NH3+])cc3)ccc12
278.379
2.57682
66.55
3
21
2
2
0.772972
6pou
2.194
2,020
M16
F
801
ki
=
23.3
uM
-4.632644
MOAD
Ki=23.3uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(CC[NH3+])cc3)ccc12
278.379
2.57682
66.55
3
21
2
2
0.772972
6pou
2.194
2,020
M16
F
803
ki
=
23.3
uM
-4.632644
MOAD
Ki=23.3uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(CC[NH3+])cc3)ccc12
278.379
2.57682
66.55
3
21
2
2
0.772972
6pov
2.047
2,020
OUG
A
503
ki
=
52.6
uM
-4.279014
MOAD
Ki=52.6uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3cccc(C[NH3+])c3)ccc12
264.352
2.53432
66.55
2
20
2
2
0.746606
6pov
2.047
2,020
OUG
B
503
ki
=
52.6
uM
-4.279014
MOAD
Ki=52.6uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3cccc(C[NH3+])c3)ccc12
264.352
2.53432
66.55
2
20
2
2
0.746606
6pov
2.047
2,020
OUG
C
504
ki
=
52.6
uM
-4.279014
MOAD
Ki=52.6uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3cccc(C[NH3+])c3)ccc12
264.352
2.53432
66.55
2
20
2
2
0.746606
6pov
2.047
2,020
OUG
D
503
ki
=
52.6
uM
-4.279014
MOAD
Ki=52.6uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3cccc(C[NH3+])c3)ccc12
264.352
2.53432
66.55
2
20
2
2
0.746606
6pox
2.197
2,020
OSJ
A
503
ki
=
18.2
uM
-4.739929
MOAD
Ki=18.2uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
CCOc1ccc(-c2ccc3c(C)cc(N)nc3c2)cc1C[NH3+]
308.405
2.93302
75.78
4
23
2
3
0.777796
6pox
2.197
2,020
OSJ
B
503
ki
=
18.2
uM
-4.739929
MOAD
Ki=18.2uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
CCOc1ccc(-c2ccc3c(C)cc(N)nc3c2)cc1C[NH3+]
308.405
2.93302
75.78
4
23
2
3
0.777796
6pox
2.197
2,020
OSJ
C
503
ki
=
18.2
uM
-4.739929
MOAD
Ki=18.2uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
CCOc1ccc(-c2ccc3c(C)cc(N)nc3c2)cc1C[NH3+]
308.405
2.93302
75.78
4
23
2
3
0.777796
6pox
2.197
2,020
OSJ
D
503
ki
=
18.2
uM
-4.739929
MOAD
Ki=18.2uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
CCOc1ccc(-c2ccc3c(C)cc(N)nc3c2)cc1C[NH3+]
308.405
2.93302
75.78
4
23
2
3
0.777796
6poy
2.3
2,020
OSG
A
503
ki
=
12.9
uM
-4.88941
MOAD
Ki=12.9uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
CCCOc1ccc(-c2ccc3c(C)cc(N)nc3c2)cc1C[NH3+]
322.432
3.32312
75.78
5
24
2
3
0.756322
6poy
2.3
2,020
OSG
B
503
ki
=
12.9
uM
-4.88941
MOAD
Ki=12.9uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
CCCOc1ccc(-c2ccc3c(C)cc(N)nc3c2)cc1C[NH3+]
322.432
3.32312
75.78
5
24
2
3
0.756322
6poy
2.3
2,020
OSG
C
503
ki
=
12.9
uM
-4.88941
MOAD
Ki=12.9uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
CCCOc1ccc(-c2ccc3c(C)cc(N)nc3c2)cc1C[NH3+]
322.432
3.32312
75.78
5
24
2
3
0.756322
6poy
2.3
2,020
OSG
D
503
ki
=
12.9
uM
-4.88941
MOAD
Ki=12.9uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
CCCOc1ccc(-c2ccc3c(C)cc(N)nc3c2)cc1C[NH3+]
322.432
3.32312
75.78
5
24
2
3
0.756322
6poz
2.2
2,020
OSD
A
510
ki
=
20.2
uM
-4.694649
MOAD
Ki=20.2uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OC(C)C)c(C[NH3+])c3)ccc12
322.432
3.32152
75.78
4
24
2
3
0.773406
6poz
2.2
2,020
OSD
A
503
ki
=
20.2
uM
-4.694649
MOAD
Ki=20.2uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OC(C)C)c(C[NH3+])c3)ccc12
322.432
3.32152
75.78
4
24
2
3
0.773406
6poz
2.2
2,020
OSD
B
502
ki
=
20.2
uM
-4.694649
MOAD
Ki=20.2uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OC(C)C)c(C[NH3+])c3)ccc12
322.432
3.32152
75.78
4
24
2
3
0.773406
6poz
2.2
2,020
OSD
C
509
ki
=
20.2
uM
-4.694649
MOAD
Ki=20.2uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OC(C)C)c(C[NH3+])c3)ccc12
322.432
3.32152
75.78
4
24
2
3
0.773406
6poz
2.2
2,020
OSD
C
503
ki
=
20.2
uM
-4.694649
MOAD
Ki=20.2uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OC(C)C)c(C[NH3+])c3)ccc12
322.432
3.32152
75.78
4
24
2
3
0.773406
6poz
2.2
2,020
OSD
D
502
ki
=
20.2
uM
-4.694649
MOAD
Ki=20.2uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OC(C)C)c(C[NH3+])c3)ccc12
322.432
3.32152
75.78
4
24
2
3
0.773406
6pp0
1.97
2,020
OUP
A
503
ki
=
22.8
uM
-4.642065
MOAD
Ki=22.8uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OCC4CCC4)c(C[NH3+])c3)ccc12
348.47
3.71322
75.78
5
26
2
3
0.737778
6pp0
1.97
2,020
OUP
B
503
ki
=
22.8
uM
-4.642065
MOAD
Ki=22.8uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OCC4CCC4)c(C[NH3+])c3)ccc12
348.47
3.71322
75.78
5
26
2
3
0.737778
6pp0
1.97
2,020
OUP
C
503
ki
=
22.8
uM
-4.642065
MOAD
Ki=22.8uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OCC4CCC4)c(C[NH3+])c3)ccc12
348.47
3.71322
75.78
5
26
2
3
0.737778
6pp0
1.97
2,020
OUP
D
503
ki
=
22.8
uM
-4.642065
MOAD
Ki=22.8uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OCC4CCC4)c(C[NH3+])c3)ccc12
348.47
3.71322
75.78
5
26
2
3
0.737778
6pp1
1.76
2,020
OU1
A
503
ki
=
21
uM
-4.677781
MOAD
Ki=21.0uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OCC4CC4)c(C[NH3+])c3)ccc12
334.443
3.32312
75.78
5
25
2
3
0.751309
6pp1
1.76
2,020
OU1
B
504
ki
=
21
uM
-4.677781
MOAD
Ki=21.0uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OCC4CC4)c(C[NH3+])c3)ccc12
334.443
3.32312
75.78
5
25
2
3
0.751309
6pp1
1.76
2,020
OU1
C
503
ki
=
21
uM
-4.677781
MOAD
Ki=21.0uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OCC4CC4)c(C[NH3+])c3)ccc12
334.443
3.32312
75.78
5
25
2
3
0.751309
6pp1
1.76
2,020
OU1
D
504
ki
=
21
uM
-4.677781
MOAD
Ki=21.0uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OCC4CC4)c(C[NH3+])c3)ccc12
334.443
3.32312
75.78
5
25
2
3
0.751309
6pp2
2.02
2,020
OUM
A
503
ki
=
8.31
uM
-5.080399
MOAD
Ki=8.31uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OCc4ccc(C#N)cc4)c(C[NH3+])c3)ccc12
395.486
3.985
99.57
5
30
2
4
0.533624
6pp2
2.02
2,020
OUM
B
503
ki
=
8.31
uM
-5.080399
MOAD
Ki=8.31uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OCc4ccc(C#N)cc4)c(C[NH3+])c3)ccc12
395.486
3.985
99.57
5
30
2
4
0.533624
6pp2
2.02
2,020
OUM
C
503
ki
=
8.31
uM
-5.080399
MOAD
Ki=8.31uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OCc4ccc(C#N)cc4)c(C[NH3+])c3)ccc12
395.486
3.985
99.57
5
30
2
4
0.533624
6pp2
2.02
2,020
OUM
D
503
ki
=
8.31
uM
-5.080399
MOAD
Ki=8.31uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OCc4ccc(C#N)cc4)c(C[NH3+])c3)ccc12
395.486
3.985
99.57
5
30
2
4
0.533624
6pp3
1.95
2,020
OS7
A
503
ki
=
23.7
uM
-4.625252
MOAD
Ki=23.7uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OCc4ccccn4)c(C[NH3+])c3)ccc12
371.464
3.50832
88.67
5
28
2
4
0.56179
6pp3
1.95
2,020
OS7
B
503
ki
=
23.7
uM
-4.625252
MOAD
Ki=23.7uM
P29474,P29474
Nitric oxide synthase, endothelial,Nitric oxide synthase, endothelial
Cc1cc(N)nc2cc(-c3ccc(OCc4ccccn4)c(C[NH3+])c3)ccc12
371.464
3.50832
88.67
5
28
2
4
0.56179