PDBID
stringlengths
4
4
Resolution
stringlengths
1
13
Year
int64
1.98k
2.02k
Ligand Name
stringlengths
1
7
Ligand Chain
stringclasses
53 values
Ligand Residue Number
stringlengths
1
9
Binding Affinity Measurement
stringclasses
4 values
Binding Affinity Sign
stringclasses
6 values
Binding Affinity Value
float64
0
500M
Binding Affinity Unit
stringclasses
6 values
Log Binding Affinity
float64
-14
2.97
Binding Affinity Source
stringclasses
3 values
Binding Affinity Annotation
stringlengths
6
72
Protein UniProtID
stringlengths
6
55
Protein UniProtName
stringlengths
2
575
Ligand SMILES
stringlengths
4
352
Ligand MW
float64
44
1.82k
Ligand LogP
float64
-23.01
13.7
Ligand TPSA
float64
0
786
Ligand NumRotBond
int64
0
59
Ligand NumHeavyAtoms
int64
3
120
Ligand NumHDon
int64
0
30
Ligand NumHAcc
int64
0
56
Ligand QED
float64
0.01
0.95
6uf0
1.96
2,019
Q5Y
B
701
ic50
=
230
nM
-6.638272
MOAD
ic50=230.0nM
Q14145
Kelch-like ECH-associated protein 1
COc1ccc(S(=O)(=O)Nc2ccc(N(CC(=O)[O-])S(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1
555.61
2.603
142.14
10
38
1
8
0.314723
6ufb
1.67
2,020
Q64
A
304
ki
=
4.4
nM
-8.356547
MOAD
Ki=4.4nM
P00918
Carbonic anhydrase 2
CC(=O)/C(=C/c1ccccc1)C(=O)Nc1ccc(S(N)(=O)=O)cc1
344.392
1.9451
106.33
5
24
2
4
0.490939
6ufc
1.325
2,020
Q6A
A
302
ki
=
0.45
nM
-9.346787
MOAD
Ki=0.45nM
P00918
Carbonic anhydrase 2
COc1ccc(/C=C(/C(C)=O)C(=O)Nc2ccc(S(N)(=O)=O)cc2)cc1
374.418
1.9537
115.56
6
26
2
5
0.455452
6ufd
1.48
2,020
Q6D
A
305
ki
=
2.9
nM
-8.537602
MOAD
Ki=2.9nM
P00918
Carbonic anhydrase 2
CC(=O)/C(=C/c1cccs1)C(=O)Nc1ccc(S(N)(=O)=O)cc1
350.421
2.0066
106.33
5
23
2
5
0.488499
6ufx
2.015
2,020
Q6S
A
401
ki
=
0.049
nM
-10.309804
MOAD
Ki=0.049nM
P61964
WD repeat-containing protein 5
COc1cc(CNC(=O)c2cc(Cn3ccn(C)c3=N)cc(-c3ccc(F)cc3C)c2)cc(OC)c1
488.563
4.41609
81.27
8
36
2
6
0.385427
6ugl
2.03
2,020
QOS
A
301
kd
=
2.3
uM
-5.638272
MOAD
Kd=2.3uM
A0A0F0AZW0
Helix-turn-helix transcriptional regulator
Cc1c[nH]c(=O)c(C)n1
124.143
0.38674
45.75
0
9
1
2
0.543309
6ugl
2.03
2,020
QOS
B
301
kd
=
2.3
uM
-5.638272
MOAD
Kd=2.3uM
A0A0F0AZW0
Helix-turn-helix transcriptional regulator
Cc1c[nH]c(=O)c(C)n1
124.143
0.38674
45.75
0
9
1
2
0.543309
6ugn
1.406
2,019
Q77
A
303
ki
=
763.5
nM
-6.117191
MOAD
Ki=763.5nM
P00918
Carbonic anhydrase 2
Cc1cc(C)c2c(c1)S(=O)(=O)NC(=O)N2
226.257
1.12724
75.27
0
15
2
3
0.695855
6ugn
1.406
2,019
Q77
A
302
ki
=
763.5
nM
-6.117191
MOAD
Ki=763.5nM
P00918
Carbonic anhydrase 2
Cc1cc(C)c2c(c1)S(=O)(=O)NC(=O)N2
226.257
1.12724
75.27
0
15
2
3
0.695855
6ugo
1.457
2,019
Q77
A
303
ki
=
764
nM
-6.116907
BindingDB
Ki=764nM
P00918
Carbonic anhydrase IX-mimic
Cc1cc(C)c2c(c1)S(=O)(=O)NC(=O)N2
226.257
1.12724
75.27
0
15
2
3
0.695855
6ugo
1.457
2,019
Q77
A
304
ki
=
764
nM
-6.116907
BindingDB
Ki=764nM
P00918
Carbonic anhydrase IX-mimic
Cc1cc(C)c2c(c1)S(=O)(=O)NC(=O)N2
226.257
1.12724
75.27
0
15
2
3
0.695855
6ugo
1.457
2,019
Q77
A
302
ki
=
764
nM
-6.116907
BindingDB
Ki=764nM
P00918
Carbonic anhydrase IX-mimic
Cc1cc(C)c2c(c1)S(=O)(=O)NC(=O)N2
226.257
1.12724
75.27
0
15
2
3
0.695855
6ugp
1.306
2,019
Q7A
A
302
ki
=
685.5
nM
-6.163993
MOAD
Ki=685.5nM
P00918
Carbonic anhydrase 2
O=C1Nc2c(Cl)cccc2S(=O)(=O)N1
232.648
1.1638
75.27
0
14
2
3
0.704995
6ugp
1.306
2,019
Q7A
A
303
ki
=
685.5
nM
-6.163993
MOAD
Ki=685.5nM
P00918
Carbonic anhydrase 2
O=C1Nc2c(Cl)cccc2S(=O)(=O)N1
232.648
1.1638
75.27
0
14
2
3
0.704995
6ugq
1.305
2,019
Q7A
A
302
ki
=
686
nM
-6.163676
BindingDB
Ki=686nM
P00918
Carbonic anhydrase IX-mimic
O=C1Nc2c(Cl)cccc2S(=O)(=O)N1
232.648
1.1638
75.27
0
14
2
3
0.704995
6ugq
1.305
2,019
Q7A
A
303
ki
=
686
nM
-6.163676
BindingDB
Ki=686nM
P00918
Carbonic anhydrase IX-mimic
O=C1Nc2c(Cl)cccc2S(=O)(=O)N1
232.648
1.1638
75.27
0
14
2
3
0.704995
6ugr
1.307
2,019
Q71
A
302
ki
=
533.6
nM
-6.272784
MOAD
Ki=533.6nM
P00918
Carbonic anhydrase 2
O=C1Nc2ccc(F)cc2S(=O)(=O)N1
216.193
0.6495
75.27
0
14
2
3
0.668132
6ugz
1.306
2,019
Q71
A
302
ki
=
534
nM
-6.272459
BindingDB
Ki=534nM
P00918
Carbonic anhydrase IX-mimic
O=C1Nc2ccc(F)cc2S(=O)(=O)N1
216.193
0.6495
75.27
0
14
2
3
0.668132
6uh0
1.306
2,019
PX7
A
302
ki
=
853.1
nM
-6.069
MOAD
Ki=853.1nM
P00918
Carbonic anhydrase 2
CN1C(=O)NS(=O)(=O)c2ccccc21
212.23
0.5347
66.48
0
14
1
3
0.681948
6uif
1.603
2,020
Q8P
A
401
kd
=
0.17
uM
-6.769551
MOAD
Kd=0.17uM
P61964,P61964
WD repeat domain 5,WD repeat domain 5
CNC(=O)c1nc(NS(=O)(=O)c2cc(Br)cc(Cl)c2O)cn1C1CCCC1
477.768
3.2801
113.32
5
27
3
6
0.61147
6uif
1.603
2,020
Q8P
B
401
kd
=
0.17
uM
-6.769551
MOAD
Kd=0.17uM
P61964
WD repeat domain 5
CNC(=O)c1nc(NS(=O)(=O)c2cc(Br)cc(Cl)c2O)cn1C1CCCC1
477.768
3.2801
113.32
5
27
3
6
0.61147
6uik
1.6
2,020
Q8M
A
401
kd
=
0.4
uM
-6.39794
MOAD
Kd=0.4uM
P61964,P61964
WD repeat domanin 5,WD repeat domanin 5
O=S(=O)(Nc1cn(C2CCCC2)cn1)c1cc(Br)cc(Cl)c1O
420.716
3.9205
84.22
4
23
2
5
0.784925
6uik
1.6
2,020
Q8M
B
401
kd
=
0.4
uM
-6.39794
MOAD
Kd=0.4uM
P61964
WD repeat domanin 5
O=S(=O)(Nc1cn(C2CCCC2)cn1)c1cc(Br)cc(Cl)c1O
420.716
3.9205
84.22
4
23
2
5
0.784925
6uip
3.7
2,020
Q8J
A
501
ic50
=
6.2
nM
-8.207608
BindingDB
IC50=6.2nM
Q13627
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CC[NH+]1CCN(C(=O)Nc2cc(-c3cn(C4CCOCC4)c4cnccc34)ccn2)CC1
435.552
2.2021
76.72
4
32
2
5
0.658854
6uip
3.7
2,020
Q8J
B
501
ic50
=
6.2
nM
-8.207608
BindingDB
IC50=6.2nM
Q13627,Q13627
Dual specificity tyrosine-phosphorylation-regulated kinase 1A,Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CC[NH+]1CCN(C(=O)Nc2cc(-c3cn(C4CCOCC4)c4cnccc34)ccn2)CC1
435.552
2.2021
76.72
4
32
2
5
0.658854
6uip
3.7
2,020
Q8J
C
501
ic50
=
6.2
nM
-8.207608
BindingDB
IC50=6.2nM
Q13627,Q13627
Dual specificity tyrosine-phosphorylation-regulated kinase 1A,Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CC[NH+]1CCN(C(=O)Nc2cc(-c3cn(C4CCOCC4)c4cnccc34)ccn2)CC1
435.552
2.2021
76.72
4
32
2
5
0.658854
6uj4
1.53
2,020
Q8S
A
401
kd
=
0.17
uM
-6.769551
MOAD
Kd=0.17uM
P61964,P61964
WD repeat domain 5,WD repeat domain 5
Cc1nc(NS(=O)(=O)c2cc(Br)cc(Cl)c2O)cn1C1CCCC1
434.743
4.22892
84.22
4
24
2
5
0.754017
6uj4
1.53
2,020
Q8S
B
401
kd
=
0.17
uM
-6.769551
MOAD
Kd=0.17uM
P61964
WD repeat domain 5
Cc1nc(NS(=O)(=O)c2cc(Br)cc(Cl)c2O)cn1C1CCCC1
434.743
4.22892
84.22
4
24
2
5
0.754017
6ujg
3.0
2,020
Q9A
C
601
ic50
=
7,700
nM
-5.113509
BindingDB
IC50=7700nM
O94925,O94925,O94925,O94925
Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial
CC(=O)Nc1nnc(N[C@H]2CCN(c3nnc(NC(C)=O)s3)C2)s1
368.448
0.9972
125.03
5
24
3
10
0.713592
6ujg
3.0
2,020
Q9A
D
601
ic50
=
7,700
nM
-5.113509
BindingDB
IC50=7700nM
O94925,O94925,O94925,O94925
Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial
CC(=O)Nc1nnc(N[C@H]2CCN(c3nnc(NC(C)=O)s3)C2)s1
368.448
0.9972
125.03
5
24
3
10
0.713592
6ujg
3.0
2,020
Q9A
E
601
ic50
=
7,700
nM
-5.113509
BindingDB
IC50=7700nM
O94925,O94925,O94925,O94925
Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial
CC(=O)Nc1nnc(N[C@H]2CCN(c3nnc(NC(C)=O)s3)C2)s1
368.448
0.9972
125.03
5
24
3
10
0.713592
6ujg
3.0
2,020
Q9A
F
601
ic50
=
7,700
nM
-5.113509
BindingDB
IC50=7700nM
O94925,O94925,O94925,O94925
Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial
CC(=O)Nc1nnc(N[C@H]2CCN(c3nnc(NC(C)=O)s3)C2)s1
368.448
0.9972
125.03
5
24
3
10
0.713592
6ujm
2.5
2,020
Q94
B
601
ic50
=
720
nM
-6.142668
BindingDB
IC50=720nM
O94925,O94925,O94925,O94925
Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial
CC(=O)Nc1nnc(N[C@@H]2CCN(c3nnc(NC(C)=O)s3)C2)s1
368.448
0.9972
125.03
5
24
3
10
0.713592
6ujm
2.5
2,020
Q94
D
601
ic50
=
720
nM
-6.142668
BindingDB
IC50=720nM
O94925,O94925,O94925,O94925
Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial
CC(=O)Nc1nnc(N[C@@H]2CCN(c3nnc(NC(C)=O)s3)C2)s1
368.448
0.9972
125.03
5
24
3
10
0.713592
6ukb
3.0
2,020
Q9V
A
601
ic50
=
1,005
nM
-5.997834
BindingDB
IC50=1005nM
O94925
Glutaminase kidney isoform, mitochondrial
CC(=O)Nc1nnc(OC2CCN(c3nnc(NC(C)=O)s3)CC2)s1
383.459
1.3542
122.23
5
25
2
10
0.793315
6ukb
3.0
2,020
Q9V
B
601
ic50
=
1,005
nM
-5.997834
BindingDB
IC50=1005nM
O94925,O94925
Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial
CC(=O)Nc1nnc(OC2CCN(c3nnc(NC(C)=O)s3)CC2)s1
383.459
1.3542
122.23
5
25
2
10
0.793315
6uku
1.68
2,020
QAV
A
401
ic50
=
8
nM
-8.09691
MOAD
ic50=8.0nM
null
null
COc1cc2sc(C(=O)CCC(=O)[O-])cc2cc1CCCc1cc2cc(C(=O)CCC(=O)[O-])sc2cc1OC
566.653
3.7341
132.86
14
39
0
10
0.210935
6ukv
1.83
2,020
QB1
A
401
ic50
=
1.5
nM
-8.823909
MOAD
ic50=1.5nM
null
null
COc1cc2sc(C(=O)CCC(=O)[O-])cc2cc1OCCCOc1cc2sc(C(=O)CCC(=O)[O-])cc2cc1OC
598.651
3.4067
151.32
16
41
0
12
0.138588
6ukv
1.83
2,020
QB1
B
401
ic50
=
1.5
nM
-8.823909
MOAD
ic50=1.5nM
null
null
COc1cc2sc(C(=O)CCC(=O)[O-])cc2cc1OCCCOc1cc2sc(C(=O)CCC(=O)[O-])cc2cc1OC
598.651
3.4067
151.32
16
41
0
12
0.138588
6ukx
1.93
2,020
QBA
A
401
ic50
=
17
nM
-7.769551
MOAD
ic50=17.0nM
null
null
COc1cc2cc(C(=O)CCC(=O)[O-])sc2cc1OCCCOc1cc2sc(C(=O)CCC(=O)[O-])cc2cc1OC
598.651
3.4067
151.32
16
41
0
12
0.138588
6uky
1.95
2,020
QBD
A
401
ic50
=
10
nM
-8
MOAD
ic50=10.0nM
null
null
COc1cc(CCCc2cc3sc(C(=O)CCC(=O)[O-])cc3cc2OC)c2cc(C(=O)CCC(=O)[O-])sc2c1
566.653
3.7341
132.86
14
39
0
10
0.210935
6ukz
1.52
2,020
QBG
A
401
ic50
=
4
nM
-8.39794
MOAD
ic50=4.0nM
null
null
COc1cc2sc(C(=O)CCC(=O)[O-])cc2cc1OCCOc1c(OC)cc2sc(C(=O)CCC(=O)[O-])cc2c1F
602.614
3.1557
151.32
15
41
0
12
0.146573
6ul0
1.76
2,020
QBJ
A
401
ic50
=
16
nM
-7.79588
MOAD
ic50=16.0nM
null
null
COc1cc2sc(C(=O)CCC(=O)[O-])cc2cc1/C=C\COc1cc2cc(C(=O)CCC(=O)[O-])sc2cc1OC
580.636
3.651
142.09
14
40
0
11
0.204289
6ul5
2.23
2,020
QAG
A
601
ic50
=
36.2
nM
-7.441291
MOAD
ic50=36.2nM
P03366,P03366
Reverse transcriptase p66,Reverse transcriptase p51
Cc1cc(/C=C/C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)c(F)c2)nc2ccsc12
441.491
6.3916
94.62
5
32
1
7
0.360571
6ul8
2.68
2,019
Q9J
A
401
ic50
=
50
nM
-7.30103
BindingDB
IC50=50nM
O43353
Receptor-interacting serine/threonine-protein kinase 2
NC(=O)c1c(-c2ccc3scnc3c2)nn2c1N[C@H]1C[C@H](C[C@@H]1O)C2
355.423
1.8237
106.06
2
25
3
7
0.650117
6ul8
2.68
2,019
Q9J
B
402
ic50
=
50
nM
-7.30103
BindingDB
IC50=50nM
O43353
Receptor-interacting serine/threonine-protein kinase 2
NC(=O)c1c(-c2ccc3scnc3c2)nn2c1N[C@H]1C[C@H](C[C@@H]1O)C2
355.423
1.8237
106.06
2
25
3
7
0.650117
6ul9
2.5
2,020
Q9M
B
601
ic50
=
60
nM
-7.221849
BindingDB
IC50=60nM
O94925,O94925
Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial
O=C(Cc1ccccc1)Nc1nnc(OC2CN(c3nnc(NC(=O)Cc4ccccc4)s3)C2)s1
507.601
3.0196
122.23
9
35
2
10
0.354546
6ul9
2.5
2,020
Q9M
D
601
ic50
=
60
nM
-7.221849
BindingDB
IC50=60nM
O94925,O94925
Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial
O=C(Cc1ccccc1)Nc1nnc(OC2CN(c3nnc(NC(=O)Cc4ccccc4)s3)C2)s1
507.601
3.0196
122.23
9
35
2
10
0.354546
6ulb
1.75
2,020
QA1
A
302
kd
=
6.3
nM
-8.200659
BindingDB
Kd=6.3nM
P04278
Sex hormone-binding globulin
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C
337.463
4.221
46.26
0
25
1
3
0.721043
6ulj
2.69
2,020
QAA
B
601
ic50
=
98
nM
-7.008774
BindingDB
IC50=98nM
O94925,O94925,O94925,O94925
Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial
O=C(Cc1ccccc1)Nc1ccc(OC2CCN(c3ccc(NC(=O)Cc4ccccc4)nn3)CC2)nn1
523.597
3.6768
122.23
9
39
2
8
0.340771
6ulj
2.69
2,020
QAA
C
601
ic50
=
98
nM
-7.008774
BindingDB
IC50=98nM
O94925,O94925,O94925,O94925
Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial
O=C(Cc1ccccc1)Nc1ccc(OC2CCN(c3ccc(NC(=O)Cc4ccccc4)nn3)CC2)nn1
523.597
3.6768
122.23
9
39
2
8
0.340771
6um8
2.33
2,020
QCG
A
305
ki
=
0.17
uM
-6.769551
MOAD
Ki=0.17uM
P12497,P12497
Integrase,Integrase
Cc1nc2cc(-c3ccccc3)nn2c(-c2cc(F)c3c(c2C)CCCO3)c1[C@H](OC(C)(C)C)C(=O)[O-]
502.566
4.75034
88.78
5
37
0
7
0.391372
6um8
2.33
2,020
QCG
B
303
ki
=
0.17
uM
-6.769551
MOAD
Ki=0.17uM
P12497,P12497
Integrase,Integrase
Cc1nc2cc(-c3ccccc3)nn2c(-c2cc(F)c3c(c2C)CCCO3)c1[C@H](OC(C)(C)C)C(=O)[O-]
502.566
4.75034
88.78
5
37
0
7
0.391372
6umc
2.75
2,020
U27
A
601
ic50
=
36
nM
-7.443697
BindingDB
IC50=36nM
O94925,O94925
Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial
O=C(Cc1ccccc1)Nc1nnc(O[C@@H]2CCN(c3nnc(NC(=O)Cc4ccccc4)s3)C2)s1
521.628
3.4097
122.23
9
36
2
10
0.343653
6umc
2.75
2,020
U27
D
601
ic50
=
36
nM
-7.443697
BindingDB
IC50=36nM
O94925,O94925
Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial
O=C(Cc1ccccc1)Nc1nnc(O[C@@H]2CCN(c3nnc(NC(=O)Cc4ccccc4)s3)C2)s1
521.628
3.4097
122.23
9
36
2
10
0.343653
6umf
2.68
2,020
QAM
B
601
ic50
=
207
nM
-6.68403
BindingDB
IC50=207nM
O94925,O94925,O94925,O94925
Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial
Nc1nnc(N2CCC(Oc3nnc(NC(=O)Cc4ccccc4)s3)CC2)s1
417.52
2.2008
119.15
6
28
2
10
0.626415
6umf
2.68
2,020
QAM
C
601
ic50
=
207
nM
-6.68403
BindingDB
IC50=207nM
O94925,O94925,O94925,O94925
Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial,Glutaminase kidney isoform, mitochondrial
Nc1nnc(N2CCC(Oc3nnc(NC(=O)Cc4ccccc4)s3)CC2)s1
417.52
2.2008
119.15
6
28
2
10
0.626415
6uml
3.58
2,020
Y70
C
502
ic50
=
2,000
nM
-5.69897
BindingDB
IC50=2000nM
Q96SW2,Q9UJQ4
Protein cereblon,Sal-like protein 4
Nc1cccc2c1C(=O)N([C@H]1CCC(=O)NC1=O)C2=O
273.248
-0.33
109.57
1
20
2
5
0.537539
6unj
2.6
2,020
QDY
A
602
ic50
=
356
nM
-6.44855
BindingDB
IC50=356nM
P08684
Cytochrome P450 3A4
CC(C)(C)OC(=O)N[C@@H](CS[C@@H](Cc1ccccc1)C(=O)NCCc1cccnc1)Cc1cccc2ccccc12
569.771
6.374
80.32
12
41
2
5
0.20716
6unj
2.6
2,020
QDY
B
602
ic50
=
356
nM
-6.44855
BindingDB
IC50=356nM
P08684
Cytochrome P450 3A4
CC(C)(C)OC(=O)N[C@@H](CS[C@@H](Cc1ccccc1)C(=O)NCCc1cccnc1)Cc1cccc2ccccc12
569.771
6.374
80.32
12
41
2
5
0.20716
6uns
2.3
2,021
LDN
A
501
ic50
=
17
nM
-7.769551
BindingDB
IC50=17nM
Q04771
Activin receptor type-1
c1ccc2c(-c3cnn4cc(-c5ccc(N6CC[NH2+]CC6)cc5)cnc34)ccnc2c1
407.501
2.9949
62.93
3
31
1
5
0.499475
6uns
2.3
2,021
LDN
B
501
ic50
=
17
nM
-7.769551
BindingDB
IC50=17nM
Q04771
Activin receptor type-1
c1ccc2c(-c3cnn4cc(-c5ccc(N6CC[NH2+]CC6)cc5)cnc34)ccnc2c1
407.501
2.9949
62.93
3
31
1
5
0.499475
6uo8
NMR
2,020
QD7
A
1001
ec50
=
200
nM
-6.69897
BindingDB
EC50=200nM
Q9UBS5
Gamma-aminobutyric acid type B receptor subunit 1
C[P@](=O)([O-])CCC[NH3+]
137.119
-1.1134
67.77
3
8
1
2
0.500784
6uo8
NMR
2,020
QDA
A
1009
ec50
=
741
nM
-6.130182
BindingDB
EC50=741nM
Q9UBS5,O75899
Gamma-aminobutyric acid type B receptor subunit 1,Gamma-aminobutyric acid type B receptor subunit 2
CSc1nc(NC2CCCC2)c([N+](=O)[O-])c(NC2CCCC2)n1
337.449
3.8157
92.98
6
23
2
7
0.352634
6uo9
NMR
2,020
QD7
A
1001
ec50
=
200
nM
-6.69897
BindingDB
EC50=200nM
Q9UBS5
Gamma-aminobutyric acid type B receptor subunit 1
C[P@](=O)([O-])CCC[NH3+]
137.119
-1.1134
67.77
3
8
1
2
0.500784
6uoi
1.953
2,019
MLA
A
602
ic50
=
5.6
mM
-2.251812
MOAD
ic50=5.6mM
E9AE57,E9AE57
Fumarate hydratase 2,Fumarate hydratase 2
O=C([O-])CC(=O)[O-]
102.045
-3.1237
80.26
2
7
0
4
0.345207
6uoi
1.953
2,019
MLA
A
601
ic50
=
5.6
mM
-2.251812
MOAD
ic50=5.6mM
E9AE57,E9AE57
Fumarate hydratase 2,Fumarate hydratase 2
O=C([O-])CC(=O)[O-]
102.045
-3.1237
80.26
2
7
0
4
0.345207
6uoi
1.953
2,019
MLA
A
603
ic50
=
5.6
mM
-2.251812
MOAD
ic50=5.6mM
E9AE57
Fumarate hydratase 2
O=C([O-])CC(=O)[O-]
102.045
-3.1237
80.26
2
7
0
4
0.345207
6uoi
1.953
2,019
MLA
B
602
ic50
=
5.6
mM
-2.251812
MOAD
ic50=5.6mM
E9AE57,E9AE57
Fumarate hydratase 2,Fumarate hydratase 2
O=C([O-])CC(=O)[O-]
102.045
-3.1237
80.26
2
7
0
4
0.345207
6uoi
1.953
2,019
MLA
B
601
ic50
=
5.6
mM
-2.251812
MOAD
ic50=5.6mM
E9AE57,E9AE57
Fumarate hydratase 2,Fumarate hydratase 2
O=C([O-])CC(=O)[O-]
102.045
-3.1237
80.26
2
7
0
4
0.345207
6uoi
1.953
2,019
MLA
B
603
ic50
=
5.6
mM
-2.251812
MOAD
ic50=5.6mM
E9AE57
Fumarate hydratase 2
O=C([O-])CC(=O)[O-]
102.045
-3.1237
80.26
2
7
0
4
0.345207
6uoj
2.35
2,019
SIN
A
602
ic50
=
33.7
mM
-1.47237
MOAD
ic50=33.7mM
E9AE57,E9AE57
Fumarate hydratase 2,Fumarate hydratase 2
O=C([O-])CCC(=O)[O-]
116.072
-2.7336
80.26
3
8
0
4
0.40049
6uoj
2.35
2,019
SIN
B
602
ic50
=
33.7
mM
-1.47237
MOAD
ic50=33.7mM
E9AE57,E9AE57
Fumarate hydratase 2,Fumarate hydratase 2
O=C([O-])CCC(=O)[O-]
116.072
-2.7336
80.26
3
8
0
4
0.40049
6uoz
1.532
2,020
QF1
A
401
kd
=
100
nM
-7
BindingDB
Kd=100nM
P61964,P61964
WD repeat domain 5,WD repeat domain 5
CS(=O)(=O)c1nc(NS(=O)(=O)c2cc(Br)cc(Cl)c2O)cn1C1CCCC1
498.808
3.324
118.36
5
27
2
7
0.652652
6uoz
1.532
2,020
QF1
B
401
kd
=
100
nM
-7
BindingDB
Kd=100nM
P61964
WD repeat domain 5
CS(=O)(=O)c1nc(NS(=O)(=O)c2cc(Br)cc(Cl)c2O)cn1C1CCCC1
498.808
3.324
118.36
5
27
2
7
0.652652
6upe
2.244
2,020
OGS
A
302
ki
=
56
uM
-4.251812
MOAD
Ki=56.0uM
E1WGG9
Trehalose-phosphate phosphatase
CCCCCCCCc1ccc(O[C@H]2O[C@H](COS(=O)(=O)[O-])[C@@H](O)[C@H](O)[C@H]2O)cc1
447.526
1.2528
145.58
12
30
3
9
0.244702
6upe
2.244
2,020
OGS
B
302
ki
=
56
uM
-4.251812
MOAD
Ki=56.0uM
E1WGG9
Trehalose-phosphate phosphatase
CCCCCCCCc1ccc(O[C@H]2O[C@H](COS(=O)(=O)[O-])[C@@H](O)[C@H](O)[C@H]2O)cc1
447.526
1.2528
145.58
12
30
3
9
0.244702
6upg
1.393
2,020
KEQ
A
402
kd
=
10,400
nM
-4.982967
BindingDB
Kd=10400nM
P9WPP7
Mycocyclosin synthase
COc1ccc(C[C@@H]2NC(=O)[C@H](Cc3ccc(O)cc3)NC2=O)cc1
340.379
1.1692
87.66
5
25
3
4
0.762397
6upj
2.34
1,997
NIU
A
100
ki
=
480
nM
-6.318759
MOAD
Ki=480.0nM
P04584,P04584
HIV-2 PROTEASE,HIV-2 PROTEASE
CC[C@@H](c1ccccc1)c1c(O)c2c(oc1=O)CCCCC2
298.382
4.1562
50.44
3
22
1
3
0.865745
6uqd
2.02
2,020
QF4
A
501
ic50
=
29
nM
-7.537602
MOAD
ic50=29.0nM
P0C0J0,P0C0J0
Streptopain,Streptopain
N#C[C@H](Cc1cccc(N=[S@@](=O)(F)N2CCC(C(N)=O)CC2)c1)NC(=O)OCc1ccccc1
487.557
3.14398
137.88
8
34
2
6
0.551065
6uqd
2.02
2,020
QF4
B
501
ic50
=
29
nM
-7.537602
MOAD
ic50=29.0nM
P0C0J0,P0C0J0
Streptopain,Streptopain
N#C[C@H](Cc1cccc(N=[S@@](=O)(F)N2CCC(C(N)=O)CC2)c1)NC(=O)OCc1ccccc1
487.557
3.14398
137.88
8
34
2
6
0.551065
6ur8
NMR
2,020
QMR
A
702
ki
=
0.48
nM
-9.318759
BindingDB
Ki=0.480nM
P17787
Neuronal acetylcholine receptor subunit beta-2
c1cnc2cc3c(cc2n1)[C@@H]1C[NH2+]C[C@H]3C1
212.276
0.7777
42.39
0
16
1
2
0.700858
6urc
2.2
2,019
QFV
A
1001
ic50
=
13
nM
-7.886057
BindingDB
IC50=13nM
O75460,O75460
Serine/threonine-protein kinase/endoribonuclease IRE1,Serine/threonine-protein kinase/endoribonuclease IRE1
Cc1ccc2c(NS(=O)(=O)c3ccccc3Cl)cccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CCC[NH2+]C2)n1
602.14
5.38442
122.71
8
42
3
7
0.218031
6urc
2.2
2,019
QFV
B
1001
ic50
=
13
nM
-7.886057
BindingDB
IC50=13nM
O75460,O75460
Serine/threonine-protein kinase/endoribonuclease IRE1,Serine/threonine-protein kinase/endoribonuclease IRE1
Cc1ccc2c(NS(=O)(=O)c3ccccc3Cl)cccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CCC[NH2+]C2)n1
602.14
5.38442
122.71
8
42
3
7
0.218031
6urw
2.4
2,020
R7T
A
324
ic50
=
32
uM
-4.49485
MOAD
ic50=32.0uM
P02879
Ricin
O=C([O-])c1ccc(Cc2cccs2)cc1
217.269
1.7024
40.13
3
15
0
3
0.784728
6urx
1.99
2,020
JMG
A
316
ic50
=
181
uM
-3.742321
MOAD
ic50=181.0uM
P02879
Ricin
O=C([O-])c1ccc(-c2ccccc2)s1
203.242
1.7786
40.13
2
14
0
3
0.745983
6ury
1.54
2,020
R6T
A
301
ic50
=
400
uM
-3.39794
MOAD
ic50=400.0uM
P02879,P02879
Ricin,Ricin
NC(=O)c1cccc2c1-c1ccccc1C2=O
223.231
1.9969
60.16
1
17
1
2
0.685433
6us2
1.80012657096
2,020
S3O
A
201
ki
=
5.2
pM
-11.283997
MOAD
Ki=5.2pM
P36639
7,8-dihydro-8-oxoguanine triphosphatase
CC(=O)Nc1cc2c(c(-c3cccc(C)c3C)n1)CCCN2
295.386
3.68194
54.02
2
22
2
3
0.888276
6us3
1.47028917623
2,020
8JF
A
201
ic50
=
81
nM
-7.091515
MOAD
ic50=81.0nM
P36639
7,8-dihydro-8-oxoguanine triphosphatase
CC(=O)Nc1cc2ncccc2c(-c2cccc(C)c2C)n1
291.354
3.87204
54.88
2
22
1
3
0.779407
6us4
1.95032907402
2,020
GN6
A
201
ic50
=
13
nM
-7.886057
MOAD
ic50=13.0nM
P36639
7,8-dihydro-8-oxoguanine triphosphatase
Nc1nc2cccc(-c3cccc(Cl)c3Cl)n2n1
279.13
3.2853
56.21
1
18
1
4
0.743243
6usc
1.59
2,020
KO2
A
404
ic50
=
0.7
mM
-3.154902
MOAD
ic50=0.7mM
Q8WWA0
Intelectin-1
C=CCO[C@@]1(C(=O)[O-])O[C@H]([C@H](O)CO)[C@H](O)[C@H](O)[C@@H]1O
293.248
-4.5301
159.74
6
20
5
9
0.303801
6usc
1.59
2,020
KO2
B
404
ic50
=
0.7
mM
-3.154902
MOAD
ic50=0.7mM
Q8WWA0,Q8WWA0
Intelectin-1,Intelectin-1
C=CCO[C@@]1(C(=O)[O-])O[C@H]([C@H](O)CO)[C@H](O)[C@H](O)[C@@H]1O
293.248
-4.5301
159.74
6
20
5
9
0.303801
6usf
NMR
2,020
QMR
D
502
ki
=
0.48
nM
-9.318759
BindingDB
Ki=0.480nM
P17787
Neuronal acetylcholine receptor subunit beta-2
c1cnc2cc3c(cc2n1)[C@@H]1C[NH2+]C[C@H]3C1
212.276
0.7777
42.39
0
16
1
2
0.700858
6usn
2.773
2,019
QGV
A
310
ic50
=
180
nM
-6.744727
BindingDB
IC50=180nM
P35270
Sepiapterin reductase
Cc1nn(-c2ccccn2)c2ncc(C(=O)c3ccccc3O)cc12
330.347
3.06052
80.9
3
25
1
6
0.583939
6usn
2.773
2,019
QGV
B
308
ic50
=
180
nM
-6.744727
BindingDB
IC50=180nM
P35270
Sepiapterin reductase
Cc1nn(-c2ccccn2)c2ncc(C(=O)c3ccccc3O)cc12
330.347
3.06052
80.9
3
25
1
6
0.583939
6usn
2.773
2,019
QGV
C
307
ic50
=
180
nM
-6.744727
BindingDB
IC50=180nM
P35270
Sepiapterin reductase
Cc1nn(-c2ccccn2)c2ncc(C(=O)c3ccccc3O)cc12
330.347
3.06052
80.9
3
25
1
6
0.583939
6usn
2.773
2,019
QGV
D
309
ic50
=
180
nM
-6.744727
BindingDB
IC50=180nM
P35270,P35270
Sepiapterin reductase,Sepiapterin reductase
Cc1nn(-c2ccccn2)c2ncc(C(=O)c3ccccc3O)cc12
330.347
3.06052
80.9
3
25
1
6
0.583939
6usu
2.092
2,020
QGM
A
301
ki
=
6.3
nM
-8.200659
BindingDB
Ki=6.3nM
P35439
Glutamate receptor ionotropic, NMDA 1
O=C(Nc1ccccc1)N[C@H]1C[C@H](C(=O)[O-])Nc2cc(Cl)cc(Cl)c21
379.223
2.7903
93.29
3
25
3
4
0.764716
6usy
1.26
2,020
QGS
A
301
ki
=
0.0004
uM
-9.39794
MOAD
Ki=0.0004uM
P03951
Coagulation factor XIa light chain
CC(C)c1cc(-c2ccc3c(c2)[C@H]([NH3+])CO3)cc([C@H](O)Cn2ccc3cccc(C(=O)[O-])c32)c1
456.542
3.2042
102.16
6
34
2
5
0.465097
6uux
1.5
2,020
QHM
A
302
kd
=
22
uM
-4.657577
MOAD
Kd=22.0uM
G4VLE5
Sulfotransferase
CC[NH+](CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12
357.499
2.2436
53.77
7
25
3
4
0.568632