PDBID
stringlengths
4
4
Resolution
stringlengths
1
13
Year
int64
1.98k
2.02k
Ligand Name
stringlengths
1
7
Ligand Chain
stringclasses
53 values
Ligand Residue Number
stringlengths
1
9
Binding Affinity Measurement
stringclasses
4 values
Binding Affinity Sign
stringclasses
6 values
Binding Affinity Value
float64
0
500M
Binding Affinity Unit
stringclasses
6 values
Log Binding Affinity
float64
-14
2.97
Binding Affinity Source
stringclasses
3 values
Binding Affinity Annotation
stringlengths
6
72
Protein UniProtID
stringlengths
6
55
Protein UniProtName
stringlengths
2
575
Ligand SMILES
stringlengths
4
352
Ligand MW
float64
44
1.82k
Ligand LogP
float64
-23.01
13.7
Ligand TPSA
float64
0
786
Ligand NumRotBond
int64
0
59
Ligand NumHeavyAtoms
int64
3
120
Ligand NumHDon
int64
0
30
Ligand NumHAcc
int64
0
56
Ligand QED
float64
0.01
0.95
6uuy
1.37
2,020
QHM
A
302
kd
=
2.5
uM
-5.60206
MOAD
Kd=2.5uM
A0A094ZWQ2
Sulfotransferase
CC[NH+](CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12
357.499
2.2436
53.77
7
25
3
4
0.568632
6uuy
1.37
2,020
QHM
B
302
kd
=
2.5
uM
-5.60206
MOAD
Kd=2.5uM
A0A094ZWQ2
Sulfotransferase
CC[NH+](CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12
357.499
2.2436
53.77
7
25
3
4
0.568632
6uvj
1.38
2,020
QJ1
A
205
kd
=
20
uM
-4.69897
MOAD
Kd=20.0uM
O60885
Bromodomain-containing protein 4
COC(=O)N1CCS[C@H](c2cccs2)CC1
257.38
2.9945
29.54
1
16
0
4
0.774322
6uvk
2.2
2,020
QHY
A
301
ki
=
0.53
uM
-6.275724
MOAD
Ki=0.53uM
Q6XEC0
Beta-lactamase
CCOc1ccccc1N1CCN(c2ncnc(N3CCC(C(=O)[O-])CC3)n2)CC1
411.486
0.5632
97.75
6
30
0
9
0.675264
6uvk
2.2
2,020
QHY
B
301
ki
=
0.53
uM
-6.275724
MOAD
Ki=0.53uM
Q6XEC0
Beta-lactamase
CCOc1ccccc1N1CCN(c2ncnc(N3CCC(C(=O)[O-])CC3)n2)CC1
411.486
0.5632
97.75
6
30
0
9
0.675264
6uvk
2.2
2,020
QHY
C
301
ki
=
0.53
uM
-6.275724
MOAD
Ki=0.53uM
Q6XEC0,Q6XEC0
Beta-lactamase,Beta-lactamase
CCOc1ccccc1N1CCN(c2ncnc(N3CCC(C(=O)[O-])CC3)n2)CC1
411.486
0.5632
97.75
6
30
0
9
0.675264
6uvk
2.2
2,020
QHY
D
301
ki
=
0.53
uM
-6.275724
MOAD
Ki=0.53uM
Q6XEC0,Q6XEC0
Beta-lactamase,Beta-lactamase
CCOc1ccccc1N1CCN(c2ncnc(N3CCC(C(=O)[O-])CC3)n2)CC1
411.486
0.5632
97.75
6
30
0
9
0.675264
6uvm
1.51
2,020
QJA
A
201
kd
=
510
uM
-3.29243
MOAD
Kd=510.0uM
O60885
Bromodomain-containing protein 4
CC(=O)N1C=CS[C@H](c2cccs2)CC1
239.365
3.2458
20.31
1
15
0
3
0.74954
6uvp
1.56
2,019
QJJ
A
401
ic50
>=
100,000
nM
-4
BindingDB
IC50=>100000nM
P56817
Beta-secretase 1
NC1=[NH+][C@@]2([C@H]3C[C@@H]3NC(=O)c3ccc(F)cn3)COC[C@H]2CS1
337.4
-1.1337
91.21
3
23
3
5
0.649031
6uvp
1.56
2,019
QJJ
B
403
ic50
>=
100,000
nM
-4
BindingDB
IC50=>100000nM
P56817
Beta-secretase 1
NC1=[NH+][C@@]2([C@H]3C[C@@H]3NC(=O)c3ccc(F)cn3)COC[C@H]2CS1
337.4
-1.1337
91.21
3
23
3
5
0.649031
6uvp
1.56
2,019
QJJ
B
401
ic50
>=
100,000
nM
-4
BindingDB
IC50=>100000nM
P56817
Beta-secretase 1
NC1=[NH+][C@@]2([C@H]3C[C@@H]3NC(=O)c3ccc(F)cn3)COC[C@H]2CS1
337.4
-1.1337
91.21
3
23
3
5
0.649031
6uvp
1.56
2,019
QJJ
B
402
ic50
>=
100,000
nM
-4
BindingDB
IC50=>100000nM
P56817,P56817
Beta-secretase 1,Beta-secretase 1
NC1=[NH+][C@@]2([C@H]3C[C@@H]3NC(=O)c3ccc(F)cn3)COC[C@H]2CS1
337.4
-1.1337
91.21
3
23
3
5
0.649031
6uvv
1.63
2,019
QJV
A
401
ic50
=
6.64
uM
-5.177832
MOAD
ic50=6.64uM
P56817
Beta-secretase 1
CCCCNC(=O)[C@@H]1C[C@H]1[C@]12COC[C@H]1CSC(N)=[NH+]2
298.432
-0.9339
78.32
5
20
3
4
0.572943
6uvv
1.63
2,019
QJV
B
401
ic50
=
6.64
uM
-5.177832
MOAD
ic50=6.64uM
P56817
Beta-secretase 1
CCCCNC(=O)[C@@H]1C[C@H]1[C@]12COC[C@H]1CSC(N)=[NH+]2
298.432
-0.9339
78.32
5
20
3
4
0.572943
6uvy
1.71
2,019
QJP
A
401
ic50
=
0.99
uM
-6.004365
MOAD
ic50=0.99uM
P56817
Beta-secretase 1
C[C@@H]1C[C@H]1CNC(=O)[C@@H]1C[C@H]1[C@]12COC[C@H]1CSC(N)=[NH+]2
310.443
-1.078
78.32
4
21
3
4
0.617321
6uvy
1.71
2,019
QJP
B
401
ic50
=
0.99
uM
-6.004365
MOAD
ic50=0.99uM
P56817
Beta-secretase 1
C[C@@H]1C[C@H]1CNC(=O)[C@@H]1C[C@H]1[C@]12COC[C@H]1CSC(N)=[NH+]2
310.443
-1.078
78.32
4
21
3
4
0.617321
6uwp
1.29
2,019
QKA
A
401
ic50
=
0.028
uM
-7.552842
MOAD
ic50=0.028uM
P56817
Beta-secretase 1
C[C@@H]1C[C@H]1CNC(=O)[C@@H]1C[C@H]1[C@]12CN(c3ncccn3)C[C@H]1CSC(N)=[NH+]2
387.533
-0.798
98.11
5
27
3
6
0.612121
6uwp
1.29
2,019
QKA
B
401
ic50
=
0.028
uM
-7.552842
MOAD
ic50=0.028uM
P56817
Beta-secretase 1
C[C@@H]1C[C@H]1CNC(=O)[C@@H]1C[C@H]1[C@]12CN(c3ncccn3)C[C@H]1CSC(N)=[NH+]2
387.533
-0.798
98.11
5
27
3
6
0.612121
6uwu
2.0
2,020
QKP
A
206
ic50
~
70
nM
-7.154902
MOAD
ic50~70.0nM
O60885
Bromodomain-containing protein 4
COc1cc(OC)c2c(=O)cc(-c3cc(C)c(OC[C@H](O)C[NH+]4CCN(C)CC4)c(C)c3)oc2c1
483.585
1.66404
85.81
8
35
2
7
0.504146
6uwv
1.47
2,019
QK7
A
401
ic50
=
0.01
uM
-8
MOAD
ic50=0.01uM
P56817
Beta-secretase 1
C[C@@H]1C[C@H]1COC(C)(C)[C@@H]1C[C@H]1[C@]12CN(c3ncccn3)C[C@H]1CSC(N)=[NH+]2
402.588
0.881
78.24
6
28
2
6
0.73559
6uwv
1.47
2,019
QK7
B
401
ic50
=
0.01
uM
-8
MOAD
ic50=0.01uM
P56817
Beta-secretase 1
C[C@@H]1C[C@H]1COC(C)(C)[C@@H]1C[C@H]1[C@]12CN(c3ncccn3)C[C@H]1CSC(N)=[NH+]2
402.588
0.881
78.24
6
28
2
6
0.73559
6uwx
1.307
2,020
QKD
A
202
kd
=
290
uM
-3.537602
MOAD
Kd=290.0uM
O60885
Bromodomain-containing protein 4
CCOC(=O)N1CCS[C@H](c2cccs2)CC1
271.407
3.3846
29.54
2
17
0
4
0.825543
6uwy
2.95
2,020
QKG
A
501
ic50
=
25
nM
-7.60206
BindingDB
IC50=25nM
Q13627
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
COc1ccc2c3ccnc(C)c3n(CCCC(N)=O)c2c1
297.358
2.77202
70.14
5
22
1
4
0.786897
6uwy
2.95
2,020
QKG
B
501
ic50
=
25
nM
-7.60206
BindingDB
IC50=25nM
Q13627,Q13627
Dual specificity tyrosine-phosphorylation-regulated kinase 1A,Dual specificity tyrosine-phosphorylation-regulated kinase 1A
COc1ccc2c3ccnc(C)c3n(CCCC(N)=O)c2c1
297.358
2.77202
70.14
5
22
1
4
0.786897
6uwy
2.95
2,020
QKG
C
501
ic50
=
25
nM
-7.60206
BindingDB
IC50=25nM
Q13627
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
COc1ccc2c3ccnc(C)c3n(CCCC(N)=O)c2c1
297.358
2.77202
70.14
5
22
1
4
0.786897
6uwy
2.95
2,020
QKG
D
501
ic50
=
25
nM
-7.60206
BindingDB
IC50=25nM
Q13627
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
COc1ccc2c3ccnc(C)c3n(CCCC(N)=O)c2c1
297.358
2.77202
70.14
5
22
1
4
0.786897
6ux1
1.36
2,020
SAL
A
303
ic50
=
6.6
mM
-2.180456
MOAD
ic50=6.6mM
P00918
Carbonic anhydrase 2
O=C([O-])c1ccccc1O
137.114
-0.2443
60.36
1
10
1
3
0.580454
6ux9
1.71
2,020
UHJ
A
4000
ic50
=
270
nM
-6.568636
BindingDB
IC50=270nM
P48426
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
CS(=O)(=O)Nc1ccc(-c2cncc(C=C3SC(=N)NC3=O)c2)cc1
374.447
2.25877
112.01
4
25
3
6
0.710825
6ux9
1.71
2,020
UHJ
B
4000
ic50
=
270
nM
-6.568636
BindingDB
IC50=270nM
P48426
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
CS(=O)(=O)Nc1ccc(-c2cncc(/C=C3\SC(=N)NC3=O)c2)cc1
374.447
2.25877
112.01
4
25
3
6
0.710825
6uxj
1.4
2,020
FFO
A
502
kd
=
17
uM
-4.769551
MOAD
Kd=17.0uM
A0A0R0IK90,A0A0R0IK90
Serine hydroxymethyltransferase,Serine hydroxymethyltransferase
Nc1nc2c(c(=O)[nH]1)N(C=O)[C@@H](CNc1ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])cc1)CN2
471.43
-3.4005
225.5
10
34
5
11
0.214556
6uxj
1.4
2,020
FFO
B
502
kd
=
17
uM
-4.769551
MOAD
Kd=17.0uM
A0A0R0IK90,A0A0R0IK90
Serine hydroxymethyltransferase,Serine hydroxymethyltransferase
Nc1nc2c(c(=O)[nH]1)N(C=O)[C@@H](CNc1ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])cc1)CN2
471.43
-3.4005
225.5
10
34
5
11
0.214556
6uxj
1.4
2,020
FFO
C
803
kd
=
17
uM
-4.769551
MOAD
Kd=17.0uM
A0A0R0IK90,A0A0R0IK90
Serine hydroxymethyltransferase,Serine hydroxymethyltransferase
Nc1nc2c(c(=O)[nH]1)N(C=O)[C@@H](CNc1ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])cc1)CN2
471.43
-3.4005
225.5
10
34
5
11
0.214556
6uxj
1.4
2,020
FFO
D
705
kd
=
17
uM
-4.769551
MOAD
Kd=17.0uM
A0A0R0IK90,A0A0R0IK90
Serine hydroxymethyltransferase,Serine hydroxymethyltransferase
Nc1nc2c(c(=O)[nH]1)N(C=O)[C@@H](CNc1ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])cc1)CN2
471.43
-3.4005
225.5
10
34
5
11
0.214556
6uxx
2.69
2,020
QL1
A
701
ec50
=
4,600
nM
-5.337242
BindingDB
EC50=4600nM
O14744
Protein arginine N-methyltransferase 5
COc1ccc([C@@]2([C@]34C[C@H]5C[C@H](C[C@H](C5)C3)C4)[NH+]=C(N)N(C)C2=O)cc1
354.474
0.9742
69.53
3
26
2
3
0.849968
6uxy
2.57
2,020
QKY
A
701
ec50
=
50
nM
-7.30103
BindingDB
EC50=50nM
O14744
Protein arginine N-methyltransferase 5
CN1C(=O)[C@@](CCC2CCCCC2)(c2ccccc2)[NH+]=C1N
300.426
1.1097
60.3
4
22
2
2
0.874901
6uy4
2.796
2,020
QLA
A
401
ic50
=
1,000
nM
-6
BindingDB
IC50=1000nM
G4VFD7
Dihydroorotate dehydrogenase
O=C1C([O-])=C(Nc2ccc(F)cc2)C(=O)c2ccccc21
282.25
1.8887
69.23
2
21
1
4
0.912843
6uya
1.74
2,019
QL7
A
501
ki
=
1.5
nM
-8.823909
BindingDB
Ki=1.50nM,IC50=0.190000nM
Q9NWZ3,Q9NWZ3,Q9NWZ3
Interleukin-1 receptor-associated kinase 4,Interleukin-1 receptor-associated kinase 4,Interleukin-1 receptor-associated kinase 4
CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1=O
482.516
1.883
112.3
6
35
2
8
0.551779
6uya
1.74
2,019
QL7
B
502
ki
=
1.5
nM
-8.823909
BindingDB
Ki=1.50nM,IC50=0.190000nM
Q9NWZ3,Q9NWZ3,Q9NWZ3
Interleukin-1 receptor-associated kinase 4,Interleukin-1 receptor-associated kinase 4,Interleukin-1 receptor-associated kinase 4
CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1=O
482.516
1.883
112.3
6
35
2
8
0.551779
6uya
1.74
2,019
QL7
C
501
ki
=
1.5
nM
-8.823909
BindingDB
Ki=1.50nM,IC50=0.190000nM
Q9NWZ3,Q9NWZ3,Q9NWZ3
Interleukin-1 receptor-associated kinase 4,Interleukin-1 receptor-associated kinase 4,Interleukin-1 receptor-associated kinase 4
CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1=O
482.516
1.883
112.3
6
35
2
8
0.551779
6uya
1.74
2,019
QL7
D
501
ki
=
1.5
nM
-8.823909
BindingDB
Ki=1.50nM,IC50=0.190000nM
Q9NWZ3,Q9NWZ3,Q9NWZ3
Interleukin-1 receptor-associated kinase 4,Interleukin-1 receptor-associated kinase 4,Interleukin-1 receptor-associated kinase 4
CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1=O
482.516
1.883
112.3
6
35
2
8
0.551779
6uyb
1.543
2,020
QSJ
A
602
kd
=
6.2
uM
-5.207608
MOAD
Kd=6.2uM
Q15562,Q15562
Transcriptional enhancer factor TEF-4,Transcriptional enhancer factor TEF-4
COc1c(C)cc(N2C[C@@H](O)[C@@H](O)C2=O)cc1/C=C/c1ccc(Cl)cc1
373.836
2.89582
70
4
26
2
4
0.808384
6uyb
1.543
2,020
QSJ
B
602
kd
=
6.2
uM
-5.207608
MOAD
Kd=6.2uM
Q15562,Q15562
Transcriptional enhancer factor TEF-4,Transcriptional enhancer factor TEF-4
COc1c(C)cc(N2C[C@@H](O)[C@@H](O)C2=O)cc1/C=C/c1ccc(Cl)cc1
373.836
2.89582
70
4
26
2
4
0.808384
6uyc
1.658
2,020
QLV
A
501
kd
=
229
nM
-6.640165
MOAD
Kd=229.0nM
Q15562,Q15562
Transcriptional enhancer factor TEF-4,Transcriptional enhancer factor TEF-4
COc1ncc(NS(C)(=O)=O)cc1/C=C/C1CCC(F)(F)CC1
346.399
3.3004
68.29
5
23
1
4
0.888123
6uyc
1.658
2,020
QLV
B
502
kd
=
229
nM
-6.640165
MOAD
Kd=229.0nM
Q15562,Q15562
Transcriptional enhancer factor TEF-4,Transcriptional enhancer factor TEF-4
COc1ncc(NS(C)(=O)=O)cc1/C=C/C1CCC(F)(F)CC1
346.399
3.3004
68.29
5
23
1
4
0.888123
6uzu
1.5
2,020
6LU
A
302
ki
=
7
nM
-8.154902
MOAD
Ki=7.0nM
P00918
Carbonic anhydrase 2
Cc1cc(C)cc(NC(=O)Nc2ccc(S(N)(=O)=O)cc2)c1
319.386
2.59484
101.29
3
22
3
3
0.810066
6v0n
2.11
2,020
SFG
A
701
ic50
=
8,600
nM
-5.065502
BindingDB
IC50=8600nM
O14744
Protein arginine N-methyltransferase 5
Nc1ncnc2c1ncn2[C@@H]1O[C@H](C[C@@H]([NH3+])CC[C@H]([NH3+])C(=O)[O-])[C@@H](O)[C@H]1O
382.401
-4.8311
214.72
7
27
5
10
0.30973
6v0o
2.86
2,020
SFG
A
701
ic50
=
8,600
nM
-5.065502
BindingDB
IC50=8600nM
O14744
Protein arginine N-methyltransferase 5
Nc1ncnc2c1ncn2[C@@H]1O[C@H](C[C@@H]([NH3+])CC[C@H]([NH3+])C(=O)[O-])[C@@H](O)[C@H]1O
382.401
-4.8311
214.72
7
27
5
10
0.30973
6v0p
1.88
2,020
SFG
A
704
ic50
=
8,600
nM
-5.065502
BindingDB
IC50=8600nM
O14744
Protein arginine N-methyltransferase 5
Nc1ncnc2c1ncn2[C@@H]1O[C@H](C[C@@H]([NH3+])CC[C@H]([NH3+])C(=O)[O-])[C@@H](O)[C@H]1O
382.401
-4.8311
214.72
7
27
5
10
0.30973
6v0q
1.69
2,020
EAE
A
305
kd
=
4,200
nM
-5.376751
MOAD
Kd=4200.0nM
Q9NPI1,Q9NPI1
Bromodomain-containing protein 7,Bromodomain-containing protein 7
CCN1/C(=C/C(C)=O)Sc2ccc(OC)cc21
249.335
3.0576
29.54
3
17
0
4
0.770003
6v0q
1.69
2,020
EAE
B
301
kd
=
4,200
nM
-5.376751
MOAD
Kd=4200.0nM
Q9NPI1,Q9NPI1
Bromodomain-containing protein 7,Bromodomain-containing protein 7
CCN1/C(=C/C(C)=O)Sc2ccc(OC)cc21
249.335
3.0576
29.54
3
17
0
4
0.770003
6v0q
1.69
2,020
EAE
C
302
kd
=
4,200
nM
-5.376751
MOAD
Kd=4200.0nM
Q9NPI1,Q9NPI1
Bromodomain-containing protein 7,Bromodomain-containing protein 7
CCN1/C(=C/C(C)=O)Sc2ccc(OC)cc21
249.335
3.0576
29.54
3
17
0
4
0.770003
6v0q
1.69
2,020
EAE
D
302
kd
=
4,200
nM
-5.376751
MOAD
Kd=4200.0nM
Q9NPI1,Q9NPI1
Bromodomain-containing protein 7,Bromodomain-containing protein 7
CCN1C(=CC(C)=O)Sc2ccc(OC)cc21
249.335
3.0576
29.54
3
17
0
4
0.770003
6v0s
2.4
2,020
EAE
A
301
kd
=
16,000
nM
-4.79588
MOAD
Kd=16000.0nM
Q9H8M2,Q9H8M2
Bromodomain-containing protein 9,Bromodomain-containing protein 9
CCN1/C(=C/C(C)=O)Sc2ccc(OC)cc21
249.335
3.0576
29.54
3
17
0
4
0.770003
6v0s
2.4
2,020
EAE
B
301
kd
=
16,000
nM
-4.79588
MOAD
Kd=16000.0nM
Q9H8M2,Q9H8M2
Bromodomain-containing protein 9,Bromodomain-containing protein 9
CCN1C(=CC(C)=O)Sc2ccc(OC)cc21
249.335
3.0576
29.54
3
17
0
4
0.770003
6v0u
1.4
2,020
BMF
A
201
kd
=
392
nM
-6.406714
MOAD
Kd=392.0nM
O60885
Bromodomain-containing protein 4
CCOC(=O)Nc1cc(-c2ccc(C)c(NS(C)(=O)=O)c2)nn2c(C)nnc12
404.452
2.34804
127.58
5
28
2
8
0.667879
6v0x
1.5
2,020
B49
A
301
kd
=
277
uM
-3.55752
MOAD
Kd=277.0uM
Q9H8M2
Bromodomain-containing protein 9
CC[NH+](CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C
399.49
1.91784
78.43
7
29
4
2
0.537026
6v14
1.7
2,020
QMG
A
301
kd
=
82
nM
-7.086186
MOAD
Kd=82.0nM
Q9H8M2
Bromodomain-containing protein 9
CC(=O)c1cc(-c2cc(C(=O)NC3CC3)ccc2C)c2ncccn12
333.391
3.40452
63.47
4
25
1
4
0.74434
6v16
1.9
2,020
QMG
A
301
kd
=
556
nM
-6.254925
MOAD
Kd=556.0nM
Q9NPI1
Bromodomain-containing protein 7
CC(=O)c1cc(-c2cc(C(=O)NC3CC3)ccc2C)c2ncccn12
333.391
3.40452
63.47
4
25
1
4
0.74434
6v16
1.9
2,020
QMG
B
301
kd
=
556
nM
-6.254925
MOAD
Kd=556.0nM
Q9NPI1,Q9NPI1
Bromodomain-containing protein 7,Bromodomain-containing protein 7
CC(=O)c1cc(-c2cc(C(=O)NC3CC3)ccc2C)c2ncccn12
333.391
3.40452
63.47
4
25
1
4
0.74434
6v17
2.05
2,020
H1B
A
302
kd
=
148
nM
-6.829738
MOAD
Kd=148.0nM
Q9NPI1
Bromodomain-containing protein 7
CCn1cc(-c2cccc(C(F)(F)F)c2)c2sc(C(N)=[NH+]C3CCS(=O)(=O)CC3)cc2c1=O
498.572
2.1318
96.13
4
33
2
5
0.425637
6v17
2.05
2,020
H1B
B
301
kd
=
148
nM
-6.829738
MOAD
Kd=148.0nM
Q9NPI1
Bromodomain-containing protein 7
CCn1cc(-c2cccc(C(F)(F)F)c2)c2sc(C(N)=[NH+]C3CCS(=O)(=O)CC3)cc2c1=O
498.572
2.1318
96.13
4
33
2
5
0.425637
6v1b
1.35
2,020
H1B
A
302
kd
=
37
nM
-7.431798
MOAD
Kd=37.0nM
Q9H8M2
Bromodomain-containing protein 9
CCn1cc(-c2cccc(C(F)(F)F)c2)c2sc(C(N)=[NH+]C3CCS(=O)(=O)CC3)cc2c1=O
498.572
2.1318
96.13
4
33
2
5
0.425637
6v1b
1.35
2,020
H1B
B
301
kd
=
37
nM
-7.431798
MOAD
Kd=37.0nM
Q9H8M2
Bromodomain-containing protein 9
CCn1cc(-c2cccc(C(F)(F)F)c2)c2sc(C(N)=[NH+]C3CCS(=O)(=O)CC3)cc2c1=O
498.572
2.1318
96.13
4
33
2
5
0.425637
6v1e
2.3
2,020
5SW
A
301
kd
=
121
nM
-6.917215
MOAD
Kd=121.0nM
Q9NPI1
Bromodomain-containing protein 7
COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1C[NH+](C)C
354.43
1.2622
57.79
5
26
1
5
0.749548
6v1f
2.0
2,020
5U6
A
301
kd
=
418
nM
-6.378824
MOAD
Kd=418.0nM
Q9NPI1
Bromodomain-containing protein 7
COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1C[NH+](C)C
354.43
1.2622
57.79
5
26
1
5
0.749548
6v1h
1.93
2,020
BMF
A
301
kd
=
114
nM
-6.943095
MOAD
Kd=114.0nM
Q9NPI1
Bromodomain-containing protein 7
CCOC(=O)Nc1cc(-c2ccc(C)c(NS(C)(=O)=O)c2)nn2c(C)nnc12
404.452
2.34804
127.58
5
28
2
8
0.667879
6v1k
1.75
2,020
5SW
A
201
kd
>=
10,000
nM
-5
BindingDB
IC50=>100000nM,Kd=>10000nM
O60885
Bromodomain-containing protein 4
COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1C[NH+](C)C
354.43
1.2622
57.79
5
26
1
5
0.749548
6v1l
2.1
2,020
5U6
A
201
kd
=
418
nM
-6.378824
MOAD
Kd=418.0nM
O60885
Bromodomain-containing protein 4
COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1C[NH+](C)C
354.43
1.2622
57.79
5
26
1
5
0.749548
6v1u
1.73
2,020
QMG
A
201
kd
>=
10,000
nM
-5
BindingDB
Kd=>10000nM
O60885
Bromodomain-containing protein 4
CC(=O)c1cc(-c2cc(C(=O)NC3CC3)ccc2C)c2ncccn12
333.391
3.40452
63.47
4
25
1
4
0.74434
6v2f
2.0
2,020
QNG
A
300
kd
=
240
pM
-9.619789
MOAD
Kd=240.0pM
P12493,P12493
HIV-1 capsid,HIV-1 capsid
CC(C)(C#Cc1ccc(-c2ccc(Cl)c3c(NS(C)(=O)=O)nn(CC(F)(F)F)c23)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)(F)F)c3c2C(F)(F)[C@@H]2C[C@H]32)n1)S(C)(=O)=O
968.296
7.6628
157.94
11
64
2
10
0.10097
6v2f
2.0
2,020
QNG
B
300
kd
=
240
pM
-9.619789
MOAD
Kd=240.0pM
P12493,P12493,P12493,P12493
HIV-1 capsid,HIV-1 capsid,HIV-1 capsid,HIV-1 capsid
CC(C)(C#Cc1ccc(-c2ccc(Cl)c3c(NS(C)(=O)=O)nn(CC(F)(F)F)c23)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)(F)F)c3c2C(F)(F)[C@@H]2C[C@H]32)n1)S(C)(=O)=O
968.296
7.6628
157.94
11
64
2
10
0.10097
6v2f
2.0
2,020
QNG
C
300
kd
=
240
pM
-9.619789
MOAD
Kd=240.0pM
P12493,P12493
HIV-1 capsid,HIV-1 capsid
CC(C)(C#Cc1ccc(-c2ccc(Cl)c3c(NS(C)(=O)=O)nn(CC(F)(F)F)c23)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)(F)F)c3c2C(F)(F)[C@@H]2C[C@H]32)n1)S(C)(=O)=O
968.296
7.6628
157.94
11
64
2
10
0.10097
6v2f
2.0
2,020
QNG
D
300
kd
=
240
pM
-9.619789
MOAD
Kd=240.0pM
P12493,P12493
HIV-1 capsid,HIV-1 capsid
CC(C)(C#Cc1ccc(-c2ccc(Cl)c3c(NS(C)(=O)=O)nn(CC(F)(F)F)c23)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)(F)F)c3c2C(F)(F)[C@@H]2C[C@H]32)n1)S(C)(=O)=O
968.296
7.6628
157.94
11
64
2
10
0.10097
6v2f
2.0
2,020
QNG
E
300
kd
=
240
pM
-9.619789
MOAD
Kd=240.0pM
P12493,P12493
HIV-1 capsid,HIV-1 capsid
CC(C)(C#Cc1ccc(-c2ccc(Cl)c3c(NS(C)(=O)=O)nn(CC(F)(F)F)c23)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)(F)F)c3c2C(F)(F)[C@@H]2C[C@H]32)n1)S(C)(=O)=O
968.296
7.6628
157.94
11
64
2
10
0.10097
6v2f
2.0
2,020
QNG
F
300
kd
=
240
pM
-9.619789
MOAD
Kd=240.0pM
P12493,P12493
HIV-1 capsid,HIV-1 capsid
CC(C)(C#Cc1ccc(-c2ccc(Cl)c3c(NS(C)(=O)=O)nn(CC(F)(F)F)c23)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)(F)F)c3c2C(F)(F)[C@@H]2C[C@H]32)n1)S(C)(=O)=O
968.296
7.6628
157.94
11
64
2
10
0.10097
6v2u
3.78
2,020
P06
A
801
ic50
=
1
nM
-9
BindingDB
IC50=1.000000nM,EC50=529nM
P15056,P15056
Serine/threonine-protein kinase B-raf,Serine/threonine-protein kinase B-raf
CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1
519.574
5.3649
110.86
5
35
2
7
0.367049
6v2u
3.78
2,020
P06
B
801
ic50
=
1
nM
-9
BindingDB
IC50=1.000000nM,EC50=529nM
P15056,P15056
Serine/threonine-protein kinase B-raf,Serine/threonine-protein kinase B-raf
CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1
519.574
5.3649
110.86
5
35
2
7
0.367049
6v3h
NMR
2,020
QO1
A
1421
ic50
=
4
nM
-8.39794
BindingDB
IC50=4nM
Q6T3U3
NPC1-like intracellular cholesterol transporter 1
CS(=O)(=O)NCC#Cc1ccc(N2C(=O)[C@H](CC[C@H](O)c3ccc(F)cc3)[C@H]2c2ccc(O[C@@H]3O[C@H](C(=O)[O-])[C@@H](O)[C@H](O)[C@H]3O)cc2)cc1
697.714
-0.1194
205.99
11
49
5
11
0.131966
6v4c
1.97
2,020
ADP
A
301
kd
=
32.68
nM
-7.485718
MOAD
Kd=32.68nM
A0A1S4K3K8
Long form D7clu1 salivary protein
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO[P@@](=O)([O-])OP(=O)([O-])[O-])[C@@H](O)[C@H]1O
424.179
-3.642
241.09
6
27
3
15
0.378904
6v52
1.78
2,020
QPV
A
501
ic50
=
9.2
nM
-8.036212
BindingDB
IC50=9.2nM
P14902,P14902
Indoleamine 2,3-dioxygenase 1,Indoleamine 2,3-dioxygenase 1
CCCNC(=O)C1(c2ccc(NC(=O)c3cccc(Cl)c3)cc2)CCC1
370.88
4.5402
58.2
6
26
2
2
0.783766
6v52
1.78
2,020
QPV
B
501
ic50
=
9.2
nM
-8.036212
BindingDB
IC50=9.2nM
P14902,P14902
Indoleamine 2,3-dioxygenase 1,Indoleamine 2,3-dioxygenase 1
CCCNC(=O)C1(c2ccc(NC(=O)c3cccc(Cl)c3)cc2)CCC1
370.88
4.5402
58.2
6
26
2
2
0.783766
6v5n
2.4
2,020
QP7
A
1101
ic50
<=
0.5
nM
-9.30103
BindingDB
IC50=<0.500000nM
P00533,P00533,P00533
Epidermal growth factor receptor,Epidermal growth factor receptor,Epidermal growth factor receptor
OCCCc1nc(-c2ccc(F)cc2)c(-c2ccnc3[nH]c(-c4ccccc4)cc23)[nH]1
412.468
5.351
77.59
6
31
3
3
0.35174
6v5n
2.4
2,020
QP7
B
1101
ic50
<=
0.5
nM
-9.30103
BindingDB
IC50=<0.500000nM
P00533,P00533,P00533
Epidermal growth factor receptor,Epidermal growth factor receptor,Epidermal growth factor receptor
OCCCc1nc(-c2ccc(F)cc2)c(-c2ccnc3[nH]c(-c4ccccc4)cc23)[nH]1
412.468
5.351
77.59
6
31
3
3
0.35174
6v5n
2.4
2,020
QP7
C
1101
ic50
<=
0.5
nM
-9.30103
BindingDB
IC50=<0.500000nM
P00533,P00533
Epidermal growth factor receptor,Epidermal growth factor receptor
OCCCc1nc(-c2ccc(F)cc2)c(-c2ccnc3[nH]c(-c4ccccc4)cc23)[nH]1
412.468
5.351
77.59
6
31
3
3
0.35174
6v5n
2.4
2,020
QP7
D
1101
ic50
<=
0.5
nM
-9.30103
BindingDB
IC50=<0.500000nM
P00533,P00533
Epidermal growth factor receptor,Epidermal growth factor receptor
OCCCc1nc(-c2ccc(F)cc2)c(-c2ccnc3[nH]c(-c4ccccc4)cc23)[nH]1
412.468
5.351
77.59
6
31
3
3
0.35174
6v6l
2.19
2,020
QQA
A
501
ic50
=
8
nM
-8.09691
MOAD
ic50=8.0nM
P49841
Glycogen synthase kinase-3 beta
C[N@@H+]1CCN(c2ccc(NCCNc3ccc([N+](=O)[O-])c(N)n3)nc2-c2ccc(Cl)cc2Cl)C(=O)C1
532.412
2.3261
143.75
8
36
4
8
0.196712
6v6z
1.6
2,020
Q5Y
A
703
ic50
=
63
nM
-7.200659
MOAD
ic50=63.0nM
Q14145
Kelch-like ECH-associated protein 1
COc1ccc(S(=O)(=O)Nc2ccc(N(CC(=O)[O-])S(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1
555.61
2.603
142.14
10
38
1
8
0.314723
6v6z
1.6
2,020
Q5Y
B
707
ic50
=
63
nM
-7.200659
MOAD
ic50=63.0nM
Q14145,Q14145
Kelch-like ECH-associated protein 1,Kelch-like ECH-associated protein 1
COc1ccc(S(=O)(=O)Nc2ccc(N(CC(=O)[O-])S(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1
555.61
2.603
142.14
10
38
1
8
0.314723
6v6z
1.6
2,020
Q5Y
C
706
ic50
=
63
nM
-7.200659
MOAD
ic50=63.0nM
Q14145,Q14145
Kelch-like ECH-associated protein 1,Kelch-like ECH-associated protein 1
COc1ccc(S(=O)(=O)Nc2ccc(N(CC(=O)[O-])S(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1
555.61
2.603
142.14
10
38
1
8
0.314723
6v6z
1.6
2,020
Q5Y
D
704
ic50
=
63
nM
-7.200659
MOAD
ic50=63.0nM
Q14145,Q14145
Kelch-like ECH-associated protein 1,Kelch-like ECH-associated protein 1
COc1ccc(S(=O)(=O)Nc2ccc(N(CC(=O)[O-])S(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1
555.61
2.603
142.14
10
38
1
8
0.314723
6v74
2.32
2,020
ASN
C
604
kd
=
27
uM
-4.568636
MOAD
Kd=27.0uM
P14618
Pyruvate kinase PKM
NC(=O)C[C@H]([NH3+])C(=O)[O-]
132.119
-3.7778
110.86
3
9
2
3
0.410661
6v7a
2.08741757573
2,020
QQG
A
804
ic50
=
264.4
nM
-6.577739
MOAD
ic50=264.4nM
F8W4B7
Hdac6 protein
CN1C[C@]2(CC[N@H+](Cc3ccc(C(=O)NO)cc3)CC2)c2ccccc21
352.458
1.3721
57.01
3
26
3
3
0.577716
6v7w
3.0
2,020
OHN
B
301
ec50
=
139
nM
-6.856985
BindingDB
EC50=139nM
P25084
Transcriptional regulator LasR
CCCCCCCCCC(=O)CC(=O)N[C@H]1CCOC1=O
297.395
2.518
72.47
11
21
1
4
0.361181
6v7w
3.0
2,020
OHN
E
301
ec50
=
139
nM
-6.856985
BindingDB
EC50=139nM
P25084,P25084
Transcriptional regulator LasR,Transcriptional regulator LasR
CCCCCCCCCC(=O)CC(=O)N[C@H]1CCOC1=O
297.395
2.518
72.47
11
21
1
4
0.361181
6v7x
2.9
2,020
OHN
B
301
ec50
=
139
nM
-6.856985
BindingDB
EC50=139nM
P25084
Transcriptional regulator LasR
CCCCCCCCCC(=O)CC(=O)N[C@H]1CCOC1=O
297.395
2.518
72.47
11
21
1
4
0.361181
6v87
2.4
2,019
OHT
A
601
ki
=
5.7
nM
-8.244125
BindingDB
IC50=0.790000nM,EC50=10.3nM,Ki=5.7nM
P03372
Estrogen receptor
CCC(=C(c1ccc(O)cc1)c1ccc(OCC[NH+](C)C)cc1)c1ccccc1
388.531
4.2846
33.9
8
29
2
2
0.564815
6v87
2.4
2,019
OHT
B
601
ki
=
5.7
nM
-8.244125
BindingDB
IC50=0.790000nM,EC50=10.3nM,Ki=5.7nM
P03372
Estrogen receptor
CCC(=C(c1ccc(O)cc1)c1ccc(OCC[NH+](C)C)cc1)c1ccccc1
388.531
4.2846
33.9
8
29
2
2
0.564815
6v8b
3.13
2,020
QRY
A
1701
ic50
=
2,500
nM
-5.60206
BindingDB
IC50=2500nM
Q09472
Histone acetyltransferase p300
NS(=O)(=O)c1ccc(CC[NH2+][C@@H](C(=O)c2c[nH]c3ccccc23)c2ccccc2)cc1
434.541
2.5454
109.63
8
31
3
3
0.370769
6v8k
1.84
2,020
COA
A
1701
ic50
=
45,940
nM
-4.337809
BindingDB
IC50=45940nM
Q09472
Histone acetyltransferase p300
CC(C)(CO[P@](=O)([O-])O[P@](=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-])[C@@H](O)C(=O)NCCC(=O)NCCS
763.509
-4.1933
357.88
18
48
6
22
0.061896
6v8n
2.3
2,020
QS1
A
1704
ic50
<=
0.5
nM
-9.30103
BindingDB
IC50=<0.500000nM
Q09472
Histone acetyltransferase p300
C[C@H](C[NH2+][C@@H](C(=O)Nc1ccc(-c2cnn(C)c2)cn1)c1ccccc1)c1ccc(C#N)cc1
451.554
3.40068
100.21
8
34
2
5
0.428769