id stringlengths 4 8 | title stringlengths 1 642 | abstract stringlengths 50 17.9k |
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41346702 | The efficacy of oligonucleotide-based gene therapeutics in gene silencing. | Oligonucleotide-based gene therapeutics (OGTs) have emerged as a promising strategy for treating a variety of diseases, offering a tool for gene modulation at the mRNA level. Despite significant progress in OGTs development, their efficacy in both experimental and clinical settings has often fallen short of expectation... |
41346701 | Sequential release of bioactive factors from functionalized metal-organic framework hydrogel enhances interfacial osseointegration of 3D-printed titanium alloy porous scaffolds. | <b>Rationale:</b> Repairing bone defects in osteoporotic patients presents a significant clinical challenge due to inadequate osseointegration, persistent inflammation, and elevated oxidative stress. To overcome these barriers, this study proposes the development of a functionalized 3D-printed titanium alloy porous sca... |
41340138 | Multispectral and Molecular Dynamics Study on the Interactions Between α-Amylase and Four Sesquiterpene Lactone Compounds. | This study compared the inhibitory effects and mechanisms of four sesquiterpene lactones derived from Asteraceae plants on α-amylase using enzymatic kinetics, multi-spectral techniques, and molecular docking methods. It was found that compounds A, B, and C inhibited α-amylase activity through a competitive mechanism, w... |
41328711 | Obtaining single crystals containing cationic porphyrins from aqueous solutions: a systematic approach including nano-crystallization, organic modifiers and gel crystallization. | Obtaining high-quality single crystals containing charged molecules from aqueous solutions can sometimes be challenging. In this publication, we studied the crystallization of polycationic porphyrins. Crystals of three polycationic porphyrins, [5,10,15,20-tetrakis(1-methylpyridin-1-ium-4-yl)porphyrin, 5-(4-cyanophenyl)... |
41328354 | Engineering exosomes for targeted neurodegenerative therapy: innovations in biogenesis, drug loading, and clinical translation. | Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD) and multiple sclerosis (MS), are characterized by progressive neuronal dysfunction and limited therapeutic options, largely due to the restrictive nature of the... |
41328353 | FGF19 in Solid Tumors: Molecular Mechanisms, Metabolic Reprogramming, and Emerging Therapeutic Opportunities. | Fibroblast growth factor 19 (FGF19), the human orthologue of murine FGF15, is an endocrine FGF that signals through the FGFR4-β-Klotho receptor complex to regulate bile acid synthesis, glucose and lipid metabolism, and thermogenesis. Beyond its physiological role in metabolic homeostasis, aberrant expression of FGF19 h... |
41328349 | Multifunctional macrophage mimetic nanoplatform modulates vascular and epithelial double gut barriers to alleviate ulcerative colitis. | <b>Rationale:</b> In ulcerative colitis (UC), microbial products or metabolites, coupled with inflammatory stimuli, result in simultaneous damage to both the intestinal epithelial barrier (IEB) and gut vascular barrier (GVB). Current UC treatments usually focus on modulating IEB, whereas GVB-which critically regulates ... |
41328345 | State-of-the-art boron clusters for boron neutron-capture therapy. | Boron neutron-capture therapy (BNCT) is a highly precise, cell-level cancer radiotherapy. It exploits the neutron-capture reaction that occurs when low-energy thermal neutrons are absorbed by a boron-10 atom, triggering a nuclear fission reaction that releases high-energy particles to selectively kill cancer cells. BNC... |
41328341 | The application of nanotechnology in regulating mitochondrial function in tumor microenvironment for cancer therapy. | Mitochondria are involved in energy production, signal conduction, and cellular differentiation in the human body, and they determine the direction of tumorigenesis and development. Mitochondria-targeted therapy in cancer cells has been reported since researchers discovered the relationship between mitochondria and can... |
41328335 | Neutrophil-based delivery platforms: from natural mechanisms to engineered therapeutics. | Neutrophils are one of the key components of the innate immune system, and they play essential roles in various physiological processes, including phagocytosis, chemotaxis, immune sensing, and transmigration across the vascular endothelium. The synergy of neutrophil biology with nanomaterial science has led to the deve... |
41325030 | Crystal structure of Crocus vernus class IIIb chitinase: in silico ligand-binding studies and in vitro antifungal assay. | Plant chitinases are found in different organs such as stems, seeds, flowers, corms, tubers and bulbs. In this study, we report the crystal structure of the class IIIb chitinase from Crocus vernus (L.) Hill corms and a thorough comparative analysis with other plant chitinases, especially focusing on molecular-docking i... |
41320726 | Integration of Colorimetric Sensing Dyes and Multi-Substrate Arrays for Food Quality and Safety Monitoring: Design, Optimization, and Analysis. | As food safety issues gain increasing attention, the need for rapid, accurate, and low-cost detection techniques becomes essential. Colorimetric sensors, known for their rapid response, high sensitivity, low cost, and readily observable results, are playing an increasingly important role in food quality inspection. Thi... |
41307280 | Neostigmine Versus Sugammadex for Reversal of Neuromuscular Blockade in Elderly Patients: A Blinded Randomised Study. | <h4>Introduction</h4>Reversal of rocuronium-induced neuromuscular blockade (NMB) is possible with either neostigmine or sugammadex to prevent residual NMB. In adults, sugammadex provides faster reversal and has fewer side effects compared to neostigmine, even when combined with glycopyrrolate. In elderly patients, rocu... |
41289031 | Leaf it to science: Uncovering plant immune systems through technological advances. | For the past 2 yr, I have been contemplating how best to write this review that not only reflects on a few significant and nostalgic moments in my more than 3 decades of professional career in the molecular plant-microbe interaction field, but also offers my personal outlook on the future aimed at inspiring young scien... |
41273530 | Application of Molecular Modeling to Capillary Electrophoresis Enantioseparations Promoted by Cyclodextrin-Based Chiral Selectors. | In the last four decades, computational techniques have become useful tools in liquid-phase enantioseparation for modeling analyte and chiral selector structures, as well as the mobile phase implicitly and explicitly, for exploring mechanisms underlying retention and enantioseparation, and for identifying noncovalent i... |
41273529 | Nuclear Magnetic Resonance Spectroscopy Experiments to Investigate Separations of Enantiomers by Capillary Electrophoresis. | Separations of enantiomers by capillary electrophoresis (CE) are achieved upon selective interaction of each enantiomer with a chiral selector, resulting in the formation of supramolecular aggregates, or complexes, that may reach the CE detector at different velocities. In order to understand (rationalize) the enantios... |
41273525 | Application of Amino Acid-Based Chiral Ionic Liquids for Enantioseparation in Capillary Electrophoresis. | In the development of analytical methodologies to perform chiral separations, capillary electrophoresis (CE) is a well-established and one of the most powerful separation techniques. Although cyclodextrins (CDs) are by far the most employed chiral selectors to achieve the enantiomeric separation of a broad variety of c... |
41273524 | Chiral Separation in Capillary Electrophoresis Using Cyclodextrins in Combination with Hydrophobic Deep Eutectic Solvents. | Hydrophobic deep eutectic solvents (HDESs) can serve as pseudostationary phases (PSPs) in capillary electrophoresis (CE). Their integration into conventional chiral CE methodologies, such as cyclodextrin-based electrokinetic chromatography, demonstrates a synergistic effect that notably enhances chiral separation effic... |
41273523 | Cyclodextrins as Chiral Selectors in Capillary Electromigration Techniques. | Cyclodextrins (CDs) are cyclic oligosaccharides composed of glucose units connected by α(1 → 4) glycosidic bonds. These hollow toroid structures are well known for their exceptional ability to form inclusion complexes. This makes them attractive in many fields, including separation science. CDs are especially popular a... |
41273519 | Cinchona Alkaloid-Based Zwitterionic Chiral Stationary Phases Applied for Liquid Chromatographic Enantiomer Separations: An Overview. | By the early 2000s, chromatographic methods applying chiral stationary phases (CSPs) became the most effective techniques for the resolution of chiral compounds on both analytical and preparative scales. Nowadays, high-performance liquid chromatography (HPLC) employing various types of chiral selectors covalently bonde... |
41273091 | GlycoRNAdb: a database of glycoRNA sequences, structures, abundance, and glycan information across tissues and cell lines. | Glycosylated RNAs (glycoRNAs), recently discovered as cell surface molecules modified by complex N-glycans, represent a transformative frontier in RNA biology with emerging roles in immune regulation and intercellular communication. To address the lack of a dedicated resource, we developed GlycoRNAdb (http://www.glycor... |
41249866 | DisProt in 2026: enhancing intrinsically disordered proteins accessibility, deposition, and annotation. | DisProt (https://disprot.org/) is an open database integrating experimental evidence on intrinsically disordered proteins (IDPs), intrinsically disordered regions (IDRs), and their functions. Over the past two years, the database has grown over 20%, now comprising 3201 IDPs and 13 347 pieces of evidence, including over... |
41231767 | DynaRepo: the repository of macromolecular conformational dynamics. | Proteins, RNA, and DNA are central to virtually all cellular processes, often assembling into macromolecular complexes to perform their functions. While these molecules are inherently dynamic, most methods for studying their mechanisms focus on static structures. Recent deep learning advances in protein structure predi... |
41198051 | Engineered coagulation factor VIII with enhanced secretion and coagulation potential for hemophilia A gene therapy. | <h4>Abstract</h4>The major challenges of gene therapy for hemophilia A using adeno-associated virus (AAV) vectors are reducing vector doses and the long-term maintenance of stable factor VIII (FVIII). In this study, we developed engineered human B-domain-deleted FVIIIs (FVIIISQ) with enhanced secretion and coagulation ... |
41182818 | Macrocycle-DB: a comprehensive database for macrocycle-based drug discovery. | Macrocycles have gained significant attention in drug design owing to their distinctive structural and physicochemical features. Despite the abundance of available experimental data, there remains a need for a centralized resource to support macrocycle-based drug discovery. Here, we present Macrocycle-DB, the most exte... |
41174314 | Quantification of Conformational Changes of Kinase Regulators, Kinases, and Regulator-Kinase Complexes Using the TSR Algorithm. | This chapter provides step-by-step instructions on applying a triangular spatial relationship (TSR) algorithm for precise molecular recognition studies, with a focus on kinase-ligand interactions. Given the central role of kinases in cellular processes and that their dysregulation is a hallmark of cancer, the developme... |
41171132 | groovDB in 2026: a community-editable database of small molecule biosensors. | The groovDB database (https://groov.bio) was launched in 2022 with the goal of organizing information on prokaryotic ligand-inducible transcription factors (TFs). This class of proteins is important in fundamental areas of microbiology research and for biotechnological applications that develop biosensors for diagnosti... |
41144297 | Toward comfortable mosquito-proof clothing: repellent- and insecticide-free fabrics that block bites across three disease-transmitting mosquito genera. | Mosquito-borne disease and nuisance biting from mosquitoes have severe health and economic consequences. Conventional fabrics are typically not effective at providing protection against mosquito bites, and fabrics treated with repellents and/or insecticides are limited by rising insecticide resistance, risk of signific... |
41144204 | Optimized Genome Assembly Protocol for Cryptosporidium. | Whole-genome sequence data have made significant contributions to studies of the biology and transmission of Cryptosporidium spp. Well-assembled genomes, free of sequence ambiguity and structural errors, are critical for comparative genomic analysis at the species and subtype levels. The optimized method for Cryptospor... |
41129587 | Therapeutic base editing to generate a gain-of-function F9 variant for hemophilia B. | <h4>Abstract</h4>The repair of pathological gene variants is an ultimate goal in treating genetic diseases; however, developing distinct therapeutic reagents for each of the numerous variants within a gene may not be scalable. Here, we investigated whether base editing to introduce a gain-of-function variant in blood c... |
41105243 | Deprivation indices and their association with fragility fractures and bone density: evidence from a large observational cohort. | <h4>Objectives</h4>Socioeconomic deprivation as a fracture risk factor remains underexplored. We evaluated associations between deprivation indices and bone health outcomes in a UK clinical population.<h4>Methods</h4>A total of 40 951 patients aged ≥50 years underwent DXA scanning between June 2004 and May 2025 in nort... |
40985947 | Cyclodextrin-based formulations for pediatric patients: pharmaceutical prospectives and toxicological evaluation. | Pediatric drug development faces significant challenges due to age-specific physiological differences, with limited approved formulations often resulting in off-label or extemporaneous uses. Oral administration remains the most common route in children, with ideal formulations requiring dosing flexibility and palatabil... |
40938731 | Induction of moderate DNA damage enhances megakaryopoiesis and platelet production. | <h4>Abstract</h4>Megakaryocytes (MKs) are large, hematopoietic cells with a polyploid, multilobulated nucleus. Although DNA replication in MKs (endomitosis) is well studied, limited investigations have examined the impact of DNA instability on megakaryopoiesis. Poly-adenosine diphosphate (ADP) ribose polymerase (PARP) ... |
40877567 | Delta-9-tetrahydrocannabinol and Cannabidiol for Pain: Preclinical and Clinical Models. | Cannabinoids are increasingly being used to manage pain resulting from a variety of conditions. Both preclinical animal models and human studies have played a crucial role in advancing our knowledge of cannabinoids, their involvement in pain mechanisms, and their potential utility as novel analgesics. This chapter firs... |
40849742 | Inclusion Complexes of α and β -cyclodextrin with Canagliflozin Hemihydrate: Design and Characterization. | <h4>Introduction</h4>Canagliflozin hemihydrate (CANA), an antidiabetic drug that functions as a sodiumglucose co-transporter 2 (SGLT2) inhibitor, is classified under the Biopharmaceutical Classification System (BCS) as a Class IV drug, characterized by low solubility and low permeability. This study aimed to enhance th... |
40808571 | MMP-9 regulates disulphide isomerase activity of TGM2 to enhance fusion glycoprotein-mediated syncytium formation of respiratory syncytial virus. | Respiratory syncytial virus (RSV) exploits host proteases to enhance its replication efficiency; however, the precise mechanisms remain unclear. Through high-throughput screening, we identified four matrix metalloproteinase 9 (MMP-9) inhibitors (including JNJ0966 and doxycycline hyclate) that suppress RSV infection in ... |
40685734 | Single-Cell Transcriptome and Microbiome Profiling Uncover Ileal Immune Impairment in Intrauterine Growth-Retarded Piglets. | <h4>Introduction</h4>Impaired intestinal immune function is commonly observed in neonates with intrauterine growth retardation (IUGR), yet its underlying mechanisms and regulatory pathways remain poorly understood. Therefore, we aimed to investigate gene regulatory patterns and microbiota alterations in IUGR piglets.<h... |
40682809 | Prehaustoria of root hemiparasites Rhinanthus minor and Odontites vernus (Orobanchaceae) produce lignin-rich interfacial deposits closely resembling those of attached haustoria. | <h4>Background and aims</h4>Lignin and other phenolics are commonly observed at the interfaces between the haustoria of parasitic plants and tissues of their hosts. As known plant defence compounds, their accumulation at haustorial interfaces has been ascribed to mechanical and chemical resistance of host tissues. Alth... |
40679028 | Assessment of the antibacterial activity of glass ionomer cements modified by polyamidoamine and bioactive glass: An in vitro study. | <h4>Background</h4>Secondary caries is one of the main reasons for the clinical failure in dental restorations. Therefore, it is preferable for restorative materials to possess antibacterial properties, which support a longlasting restoration.<h4>Objectives</h4>The present in vitro study aimed to evaluate the effect of... |
40661051 | Targeting SUMOylation Triggers IFN-β-dependent Activation of Patient and Allogenic NK Cells in Preclinical Models of Acute Myeloid Leukemia. | NK cells can play a significant role in the antitumoral immune response. In patients with acute myeloid leukemia (AML), NK cells are, however, often found in low numbers and exhibit poor activity, contributing to leukemic progression. Allogenic NK cells are emerging as promising cellular therapies for hematologic cance... |
40635151 | DS-3939a: A TA-MUC1-Directed Antibody-Drug Conjugate with Broad Antitumor Activity. | Tumor-associated mucin-1 (TA-MUC1) is a glycoform of the MUC1 protein that is aberrantly glycosylated and is primarily observed in cancer cells. TA-MUC1 is highly expressed in various human epithelial cancers, making it an attractive target for cancer therapies. In this study, we describe the development of DS-3939a, a... |
40605158 | Sugammadex in Perioperative Neuromuscular Management: Current Advances and Best Practices. | Neuromuscular blocking agents (NMBAs) are crucial for anesthesia, enabling intubation and optimal surgical conditions. Timely reversal of blockade is critical for safe extubation and recovery. While neostigmine, a traditional reversal agent, is effective for moderate blockade, it has limitations in reversing deep block... |
40591482 | Bone remodeling, not inflammation, as the predominant pathology in modic type 1 lesions of the lumbar spine. | <h4>Purpose</h4>Lesions of the vertebral endplates (Modic changes) are associated with low back pain (LBP), and different pathological processes, including inflammation, have been proposed as causative. This study aimed to explore the relationship between [18F]FDG uptake (inflammation) and [18F]NaF uptake (bone remodel... |
40525446 | Design, Molecular Docking, <i>In Vitro</i> and <i>In Vivo</i> Evaluation of Dimenhydrinate-Cyclodextrin Complex for Fast Disintegrating Tablet. | <h4>Introduction</h4>This study aimed to formulate and evaluate dimenhydrinate (DMH) as fastdisintegrating tablets (FDTs) complexed with β-cyclodextrin (β-CD) to enhance its solubility, dissolution profile, and pharmacological performance.<h4>Methods</h4>A DMH:β-CD inclusion complex was prepared at a 1:1 molar ratio us... |
40457966 | Exploring the Therapeutic Potential of Nanocarrier-Mediated Drug Delivery in Rheumatoid Arthritis (RA) Treatment. | Rheumatoid arthritis (RA) is a chronic autoimmune disorder that leads to severe joint damage, persistent inflammation, and an increase in synovial tissue. While existing treatment modalities such as corticosteroids, disease-modifying antirheumatic drugs (DMARDs), and nonsteroidal anti-inflammatory drugs (NSAIDs) can al... |
40390226 | Porphyrin-based MOFs for Gene Delivery in Cancer Therapy: Recent Advances and Progress. | Cancer is one of the leading causes of death worldwide, which involves the uncontrolled growth of body cells. Cytotoxic chemotherapy drugs, such as tamoxifen, doxorubicin, methotrexate, and cisplatin, have shortcomings that have deprived these treatments of the desired efficiency to destroy tumor cells. Poor pharmacoki... |
40331698 | Recent Trends in Drug Delivery Systems. | Drug delivery systems are now being advanced by integrating sophisticated nanotechnologies to enhance therapeutic efficacy. Tremendous advancement has been achieved in the field of cancer therapy through the utilization of hyaluronic acid-based nanocarriers, which are well-acknowledged for their capacity to transport m... |
39965087 | Integrating state-space modeling, parameter estimation, deep learning, and docking techniques in drug repurposing: a case study on COVID-19 cytokine storm. | <h4>Objective</h4>This study addresses the significant challenges posed by emerging SARS-CoV-2 variants, particularly in developing diagnostics and therapeutics. Drug repurposing is investigated by identifying critical regulatory proteins impacted by the virus, providing rapid and effective therapeutic solutions for be... |
39946288 | The role of IgA and IgG in Mycobacterium tuberculosis infection: a cross-sectional study in Ethiopia. | <h4>Introduction</h4>Despite the high global prevalence of Mycobacterium tuberculosis (Mtb) infection in humans, most infected individuals achieve a stable immunological equilibrium, without showing clinical signs and symptoms of tuberculosis (TB). Although the role of antibodies in TB is assumed to be relatively small... |
39806973 | Facile Synthesis of Monodisperse Gold Nanorods, Gold Nanobipyramids and Gold Nanocups with Different Coatings and Evaluation of Their Cellular Cytotoxicity. | <h4>Introduction</h4>Assessing the cytotoxicity of gold nanoparticles (GNPs) has gained importance due to their development in the biomedical field.<h4>Methods</h4>In this study, we systematically synthesized gold nanorods (GNRs), gold nanobipyramids (GNBPs), and gold nanocups (GNCs) using a seed-mediated method, with ... |
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